13616:LOC100028882
gene id: 13616:LOC100028882
uniprot id: F7AL73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PSMA5
gene id: 13616:PSMA5
uniprot id: F6QW93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:DDX55
gene id: 13616:DDX55
uniprot id: F6Q001
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:CFAP52
gene id: 13616:CFAP52
uniprot id: F7EJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

13616:FADS6
gene id: 13616:FADS6
uniprot id: A0A5F8HCJ0
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

13616:RNF2
gene id: 13616:RNF2
uniprot id: F7EE54
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

13616:HTR1B
gene id: 13616:HTR1B
uniprot id: F6T6U1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

13616:HMGB2
gene id: 13616:HMGB2
uniprot id: A0A5F8GGH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

13616:MTMR12
gene id: 13616:MTMR12
uniprot id: F7BDM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

13616:NUBP1
gene id: 13616:NUBP1
uniprot id: F7GH42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

13616:NRG1
gene id: 13616:NRG1
uniprot id: A0A5F8H9D3
uniprot id: F7CPL9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

13616:CCND3
gene id: 13616:CCND3
uniprot id: F7EFT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

13616:SLC26A8
gene id: 13616:SLC26A8
uniprot id: A0A5F8GAV4
uniprot id: A0A5F8GQG5
uniprot id: A0A5F8HAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

13616:MOGAT2
gene id: 13616:MOGAT2
uniprot id: F7BUD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RPL35
gene id: 13616:RPL35
uniprot id: F6WN79
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

13616:MCTP2
gene id: 13616:MCTP2
uniprot id: F7C9M4
names: Subcellular Location Annotation
messages: Membrane

13616:CLCN1
gene id: 13616:CLCN1
uniprot id: A0A5F8GNI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

13616:PXMP2
gene id: 13616:PXMP2
uniprot id: F7BWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

13616:KIAA0922
gene id: 13616:KIAA0922
uniprot id: F6UU98
names: Similarity
messages: Belongs to the TMEM131 family.

13616:CCL19
gene id: 13616:CCL19
uniprot id: F6QYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:CREG1
gene id: 13616:CREG1
uniprot id: A0A5F8H079
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

13616:WDR82
gene id: 13616:WDR82
uniprot id: F6UGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

13616:WNT5A
gene id: 13616:WNT5A
uniprot id: F6XUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:AOX2
gene id: 13616:AOX2
uniprot id: F7CG46
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

13616:EFHB
gene id: 13616:EFHB
uniprot id: A0A5F8GBM0
uniprot id: F7G6S0
names: Subcellular Location Annotation
messages: cilium axoneme

13616:RNF146
gene id: 13616:RNF146
uniprot id: A0A5F8HJU6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

13616:FTHL17
gene id: 13616:FTHL17
uniprot id: F6QWX8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

13616:CDA
gene id: 13616:CDA
uniprot id: F7FRF9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

13616:SSX2IP
gene id: 13616:SSX2IP
uniprot id: F6QME7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

13616:NR4A2
gene id: 13616:NR4A2
uniprot id: F6SX93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

13616:LOC103099394
gene id: 13616:LOC103099394
uniprot id: F7E8E1
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100021803
gene id: 13616:LOC100021803
uniprot id: F6YQL0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:BRIX1
gene id: 13616:BRIX1
uniprot id: F7C078
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

13616:RPL30
gene id: 13616:RPL30
uniprot id: F6PGS6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

13616:OTUD7A
gene id: 13616:OTUD7A
uniprot id: F7FSS6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:MRPS12
gene id: 13616:MRPS12
uniprot id: A0A5F8GIA4
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

13616:OPRM1
gene id: 13616:OPRM1
uniprot id: F7CDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

13616:INTS7
gene id: 13616:INTS7
uniprot id: K7E250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

13616:T2R62
gene id: 13616:T2R62
uniprot id: Q2AB84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:UBA3
gene id: 13616:UBA3
uniprot id: A0A5F8G327
uniprot id: A0A5F8G4W2
uniprot id: F7BMV0
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

13616:RPL37A
gene id: 13616:RPL37A
uniprot id: A0A5F8GQ95
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

13616:PDF
gene id: 13616:PDF
uniprot id: F6YGB7
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

13616:MMP23B
gene id: 13616:MMP23B
uniprot id: F7CDE4
names: Caution
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RPS6KB2
gene id: 13616:RPS6KB2
uniprot id: F7C5A4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

13616:CHST11
gene id: 13616:CHST11
uniprot id: F6UG44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:S1PR2
gene id: 13616:S1PR2
uniprot id: K7E3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:LOC100012925
gene id: 13616:LOC100012925
uniprot id: F6TUB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

13616:IFRD1
gene id: 13616:IFRD1
uniprot id: F6ZRD1
names: Similarity
messages: Belongs to the IFRD family.

13616:GRAP
gene id: 13616:GRAP
uniprot id: A0A5F8G8D8
uniprot id: A0A5F8GEC9
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

13616:NMS
gene id: 13616:NMS
uniprot id: A0A5F8G662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

13616:TM7SF3
gene id: 13616:TM7SF3
uniprot id: F6YNC1
names: Subcellular Location Annotation
messages: Membrane

13616:CIRBP
gene id: 13616:CIRBP
uniprot id: F7E6M5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

13616:BAIAP2
gene id: 13616:BAIAP2
uniprot id: A0A5F8G6Q9
uniprot id: A0A5F8GJA3
uniprot id: F7B8V7
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

13616:ADAMTS15
gene id: 13616:ADAMTS15
uniprot id: F7E8C6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:PPIE
gene id: 13616:PPIE
uniprot id: F6YJW7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

13616:GLRX
gene id: 13616:GLRX
uniprot id: A0A5F8HC20
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

13616:CIAPIN1
gene id: 13616:CIAPIN1
uniprot id: F7D704
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

13616:NNMT
gene id: 13616:NNMT
uniprot id: F6SV98
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

13616:METAP1D
gene id: 13616:METAP1D
uniprot id: A0A5F8HDU5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

13616:SFMBT1
gene id: 13616:SFMBT1
uniprot id: F7CIK7
names: Subcellular Location Annotation
messages: Nucleus

13616:CNOT2
gene id: 13616:CNOT2
uniprot id: A0A5F8GXH6
uniprot id: F7C073
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

13616:FAM63B
gene id: 13616:FAM63B
uniprot id: F6RGW0
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

13616:DGAT2
gene id: 13616:DGAT2
uniprot id: F7CDB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:B4GALT7
gene id: 13616:B4GALT7
uniprot id: F6TER0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:ACTL10
gene id: 13616:ACTL10
uniprot id: F6Q4H1
names: Similarity
messages: Belongs to the actin family.

13616:GADD45B
gene id: 13616:GADD45B
uniprot id: F6U5E4
names: Similarity
messages: Belongs to the GADD45 family.

13616:MST1
gene id: 13616:MST1
uniprot id: F7G1K1
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:IRX6
gene id: 13616:IRX6
uniprot id: F6Z3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:PODXL
gene id: 13616:PODXL
uniprot id: K7E166
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

13616:PTX3
gene id: 13616:PTX3
uniprot id: A0A5F8H1C1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:KEG11 p12
gene id: 13616:KEG11_p12
uniprot id: Q65CJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

13616:KIF19
gene id: 13616:KIF19
uniprot id: F7CWX3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:MRPS33
gene id: 13616:MRPS33
uniprot id: F6VE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

13616:SERPINB11
gene id: 13616:SERPINB11
uniprot id: F7D0K5
names: Similarity
messages: Belongs to the serpin family.

13616:LOC100618537
gene id: 13616:LOC100618537
uniprot id: F7E9F3
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:UBE2T
gene id: 13616:UBE2T
uniprot id: F6SUA7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:ACTN3
gene id: 13616:ACTN3
uniprot id: F7EL30
names: Similarity
messages: Belongs to the alpha-actinin family.

13616:ADAM10
gene id: 13616:ADAM10
uniprot id: F6PTE7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:EPGN
gene id: 13616:EPGN
uniprot id: A0A5F8H0I0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PSMB6
gene id: 13616:PSMB6
uniprot id: F7FH35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:TFE3
gene id: 13616:TFE3
uniprot id: F6R8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

13616:LOC100011425
gene id: 13616:LOC100011425
uniprot id: F6PX60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:CCL21
gene id: 13616:CCL21
uniprot id: F7EBE9
names: Subcellular Location Annotation
messages: Secreted

13616:SLC37A2
gene id: 13616:SLC37A2
uniprot id: F6Y317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

13616:PARP6
gene id: 13616:PARP6
uniprot id: F6S5M1
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:SLC12A5
gene id: 13616:SLC12A5
uniprot id: F6WQ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:LOC100023020
gene id: 13616:LOC100023020
uniprot id: F7DSS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:POLR2E
gene id: 13616:POLR2E
uniprot id: A0A5F8HKJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

13616:LOC100024383
gene id: 13616:LOC100024383
uniprot id: A0A5F8G959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:CKS2
gene id: 13616:CKS2
uniprot id: F7DTK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

13616:VTA1
gene id: 13616:VTA1
uniprot id: A0A5F8G2Q5
uniprot id: A0A5F8HK02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

13616:CBFB
gene id: 13616:CBFB
uniprot id: F6ZRM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

13616:IL7R
gene id: 13616:IL7R
uniprot id: F7FJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

13616:CPLX3
gene id: 13616:CPLX3
uniprot id: F6YXN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

13616:CUL2
gene id: 13616:CUL2
uniprot id: A0A5F8HH30
uniprot id: F6RG61
names: Similarity
messages: Belongs to the cullin family.

13616:OBFC1
gene id: 13616:OBFC1
uniprot id: F7A106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

13616:ACOT13
gene id: 13616:ACOT13
uniprot id: A0A5F8HCZ3
names: Similarity
messages: Belongs to the thioesterase PaaI family.

13616:NR0B1
gene id: 13616:NR0B1
uniprot id: F6UEV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

13616:VN2R603
gene id: 13616:VN2R603
uniprot id: A0A5F8GTH5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:AREG
gene id: 13616:AREG
uniprot id: F7A8Y1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PSMD12
gene id: 13616:PSMD12
uniprot id: F7DST4
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

13616:STMN1
gene id: 13616:STMN1
uniprot id: F6V9E8
names: Similarity
messages: Belongs to the stathmin family.

13616:COPE
gene id: 13616:COPE
uniprot id: F7EVS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

13616:LOC100015937
gene id: 13616:LOC100015937
uniprot id: F6Z372
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:LOC100618314
gene id: 13616:LOC100618314
uniprot id: F7FZJ8
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

13616:CELF1
gene id: 13616:CELF1
uniprot id: F6VPK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

13616:SLC7A5
gene id: 13616:SLC7A5
uniprot id: A0A5F8GGD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

13616:TARS2
gene id: 13616:TARS2
uniprot id: F6ZNQ0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

13616:monDomV1R1250
gene id: 13616:monDomV1R1250
uniprot id: A0A5F8H0Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RPL27
gene id: 13616:RPL27
uniprot id: A0A5F8H0S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

13616:STAM2
gene id: 13616:STAM2
uniprot id: F7C3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

13616:INSR
gene id: 13616:INSR
uniprot id: A0A5F8GJ01
uniprot id: F7F370
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

13616:MMP8
gene id: 13616:MMP8
uniprot id: F6WLV8
names: Similarity
messages: Belongs to the peptidase M10A family.

13616:GLIPR1L1
gene id: 13616:GLIPR1L1
uniprot id: A0A5F8GHY5
names: Similarity
messages: Belongs to the CRISP family.

13616:LHX6
gene id: 13616:LHX6
uniprot id: F6TTC0
names: Subcellular Location Annotation
messages: Nucleus

13616:OST4
gene id: 13616:OST4
uniprot id: A0A5F8G9G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100018927
gene id: 13616:LOC100018927
uniprot id: F7CDT3
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:USP5
gene id: 13616:USP5
uniprot id: F7CWU5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:LOC100023355
gene id: 13616:LOC100023355
uniprot id: A0A5F8HCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TCEB1
gene id: 13616:TCEB1
uniprot id: K7E0T9
names: Similarity
messages: Belongs to the SKP1 family.

13616:LOC100617407
gene id: 13616:LOC100617407
uniprot id: F7AVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GMFG
gene id: 13616:GMFG
uniprot id: F7FMW6
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

13616:RAB3GAP2
gene id: 13616:RAB3GAP2
uniprot id: F6V9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

13616:LOC100011470
gene id: 13616:LOC100011470
uniprot id: A0A5F8G9L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

13616:CALB1
gene id: 13616:CALB1
uniprot id: F7BL42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

13616:RGS2
gene id: 13616:RGS2
uniprot id: F7FUH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

13616:LOC100026485
gene id: 13616:LOC100026485
uniprot id: F7GF51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ZNRF4
gene id: 13616:ZNRF4
uniprot id: F7D4D2
names: Subcellular Location Annotation
messages: Membrane

13616:AOC1
gene id: 13616:AOC1
uniprot id: A0A5F8GIE6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

13616:MAN2A1
gene id: 13616:MAN2A1
uniprot id: F7BEM8
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

13616:GORASP2
gene id: 13616:GORASP2
uniprot id: F7DHB7
names: Similarity
messages: Belongs to the GORASP family.

13616:HOXB5
gene id: 13616:HOXB5
uniprot id: F7E2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:SUPT20H
gene id: 13616:SUPT20H
uniprot id: F6XMB7
names: Similarity
messages: Belongs to the SPT20 family.

13616:NDUFAF3
gene id: 13616:NDUFAF3
uniprot id: F6ZJF8
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

13616:ARSJ
gene id: 13616:ARSJ
uniprot id: F7DM73
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:MAEL
gene id: 13616:MAEL
uniprot id: A0A5F8HJH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

13616:PDE8A
gene id: 13616:PDE8A
uniprot id: A0A5F8HGL4
uniprot id: F6WTB2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:HN1L
gene id: 13616:HN1L
uniprot id: F7D6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

13616:IFI30
gene id: 13616:IFI30
uniprot id: F6WUX5
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

13616:PLXNB1
gene id: 13616:PLXNB1
uniprot id: F6T7S8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100019669
gene id: 13616:LOC100019669
uniprot id: F7EVZ4
names: Similarity
messages: Belongs to the ficolin lectin family.

13616:LIX1
gene id: 13616:LIX1
uniprot id: F6SKK6
names: Similarity
messages: Belongs to the LIX1 family.

13616:MAPRE2
gene id: 13616:MAPRE2
uniprot id: F7GHT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

13616:T2R29
gene id: 13616:T2R29
uniprot id: Q2AB90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:CNKSR3
gene id: 13616:CNKSR3
uniprot id: F7EKR3
names: Similarity
messages: Belongs to the CNKSR family.

13616:DPM2
gene id: 13616:DPM2
uniprot id: A0A5F8GFF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

13616:CPNE2
gene id: 13616:CPNE2
uniprot id: A0A5F8GR65
uniprot id: A0A5F8HBU6
names: Similarity
messages: Belongs to the copine family.

13616:UCK2
gene id: 13616:UCK2
uniprot id: F7FW97
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

13616:TMEM63C
gene id: 13616:TMEM63C
uniprot id: A0A5F8GYG1
uniprot id: A0A5F8HGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

13616:SLC9A3
gene id: 13616:SLC9A3
uniprot id: A0A5F8H3F8
uniprot id: F6WMC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

13616:LOC100024842
gene id: 13616:LOC100024842
uniprot id: F7B7L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

13616:CTSO
gene id: 13616:CTSO
uniprot id: F6S7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:ALDOA
gene id: 13616:ALDOA
uniprot id: F7E0Q7
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

13616:PRPF19
gene id: 13616:PRPF19
uniprot id: F7FWM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

13616:CCNE1
gene id: 13616:CCNE1
uniprot id: A0A5F8HBJ0
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

13616:RIOK3
gene id: 13616:RIOK3
uniprot id: F7G2S4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

13616:USP3
gene id: 13616:USP3
uniprot id: A0A5F8GHN6
uniprot id: F6ZBV9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:MAU2
gene id: 13616:MAU2
uniprot id: F6RD67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

13616:RPL23A
gene id: 13616:RPL23A
uniprot id: F6RZ66
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

13616:LOC100012347
gene id: 13616:LOC100012347
uniprot id: A0A5F8HH82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:JPH1
gene id: 13616:JPH1
uniprot id: F6RFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

13616:LOC100618909
gene id: 13616:LOC100618909
uniprot id: A0A5F8H9X9
names: Similarity
messages: Belongs to the perilipin family.

13616:ANXA10
gene id: 13616:ANXA10
uniprot id: A0A5F8GAE0
names: Similarity
messages: Belongs to the annexin family.

13616:CLTB
gene id: 13616:CLTB
uniprot id: A0A5F8G6P9
uniprot id: F7DN20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

13616:MPP1
gene id: 13616:MPP1
uniprot id: F7DAK5
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

13616:OXR1
gene id: 13616:OXR1
uniprot id: A0A5F8GC45
uniprot id: A0A5F8GM99
uniprot id: F7CHC9
names: Similarity
messages: Belongs to the OXR1 family.

13616:RICTOR
gene id: 13616:RICTOR
uniprot id: A0A5F8HBY7
uniprot id: F7G7I0
names: Similarity
messages: Belongs to the RICTOR family.

13616:ST3GAL3
gene id: 13616:ST3GAL3
uniprot id: A0A5F8GKE4
uniprot id: F6Q0G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:F7
gene id: 13616:F7
uniprot id: F7D6Z7
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:OTP
gene id: 13616:OTP
uniprot id: A0A5F8GIV9
uniprot id: F6X3W5
names: Subcellular Location Annotation
messages: Nucleus

13616:ARHGEF11
gene id: 13616:ARHGEF11
uniprot id: F7E6J3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

13616:DAG1
gene id: 13616:DAG1
uniprot id: A0A5F8GMJ7
uniprot id: F7DBT8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

13616:ARL4C
gene id: 13616:ARL4C
uniprot id: F7ABF7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:LOC100618871
gene id: 13616:LOC100618871
uniprot id: A0A5F8GGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TRMT5
gene id: 13616:TRMT5
uniprot id: F6PG51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

13616:SCP2
gene id: 13616:SCP2
uniprot id: F6XNE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

13616:ATP6V0A1
gene id: 13616:ATP6V0A1
uniprot id: A0A5F8GWI7
uniprot id: F7GGI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

13616:LOC103098226
gene id: 13616:LOC103098226
uniprot id: K7E4I9
names: Subcellular Location Annotation
messages: Nucleus

13616:CFAP36
gene id: 13616:CFAP36
uniprot id: F6WGE6
names: Similarity
messages: Belongs to the CFAP36 family.

13616:CXCR4
gene id: 13616:CXCR4
uniprot id: A0A5F8GXR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane

13616:ESD
gene id: 13616:ESD
uniprot id: F6WZD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

13616:MPPE1
gene id: 13616:MPPE1
uniprot id: A0A5F8G431
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

13616:SLC39A9
gene id: 13616:SLC39A9
uniprot id: A0A5F8GEC8
uniprot id: A0A5F8HHL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

13616:HNF4G
gene id: 13616:HNF4G
uniprot id: F6PGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:WDR24
gene id: 13616:WDR24
uniprot id: F6YL80
names: Similarity
messages: Belongs to the WD repeat WDR24 family.

13616:CELF3
gene id: 13616:CELF3
uniprot id: A0A5F8GYZ7
uniprot id: F7CQQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

13616:DZIP1
gene id: 13616:DZIP1
uniprot id: A0A5F8H0T6
uniprot id: F7DWD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

13616:LOC100024102
gene id: 13616:LOC100024102
uniprot id: F6ZSS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HOXB9
gene id: 13616:HOXB9
uniprot id: F7E2Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

13616:ATP9B
gene id: 13616:ATP9B
uniprot id: A0A5F8GBY9
uniprot id: A0A5F8HEF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:POC5
gene id: 13616:POC5
uniprot id: F6Q4B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

13616:LOC100023213
gene id: 13616:LOC100023213
uniprot id: F6V2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100018507
gene id: 13616:LOC100018507
uniprot id: F6R6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:CCNK
gene id: 13616:CCNK
uniprot id: F7FQ20
names: Similarity
messages: Belongs to the cyclin family.

13616:RARRES2
gene id: 13616:RARRES2
uniprot id: F7C6M6
names: Subcellular Location Annotation
messages: Secreted

13616:SMAD9
gene id: 13616:SMAD9
uniprot id: A0A5F8GVH4
uniprot id: F6UAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:HADHA
gene id: 13616:HADHA
uniprot id: F7FE46
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

13616:AP5M1
gene id: 13616:AP5M1
uniprot id: F7BJT0
names: Subcellular Location Annotation
names: Subunit
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

13616:GATB
gene id: 13616:GATB
uniprot id: F6ZF69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

13616:MTMR3
gene id: 13616:MTMR3
uniprot id: A0A5F8G462
uniprot id: A0A5F8GB11
uniprot id: A0A5F8GV53
uniprot id: A0A5F8H441
uniprot id: F6Y6D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

13616:CCDC124
gene id: 13616:CCDC124
uniprot id: A0A5F8HBU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

13616:GIMD1
gene id: 13616:GIMD1
uniprot id: K7E119
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:NPVF
gene id: 13616:NPVF
uniprot id: F6TB25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

13616:KIAA2013
gene id: 13616:KIAA2013
uniprot id: F7FJ41
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100020400
gene id: 13616:LOC100020400
uniprot id: K7E0X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:TIMM8A
gene id: 13616:TIMM8A
uniprot id: F6YEL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

13616:C1S
gene id: 13616:C1S
uniprot id: F7CCG9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SPINK4
gene id: 13616:SPINK4
uniprot id: F7D6E1
names: Subcellular Location Annotation
messages: Secreted

13616:KEG11 p06
gene id: 13616:KEG11_p06
uniprot id: Q65CI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

13616:ME2
gene id: 13616:ME2
uniprot id: F7BC34
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

13616:ICAM5
gene id: 13616:ICAM5
uniprot id: A0A5F8GIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

13616:SEPT5
gene id: 13616:SEPT5
uniprot id: F6STB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

13616:LOC100017632
gene id: 13616:LOC100017632
uniprot id: A0A5F8G589
names: Subcellular Location Annotation
messages: nucleoplasm

13616:PRF1
gene id: 13616:PRF1
uniprot id: A0A5F8GB60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

13616:ARG1
gene id: 13616:ARG1
uniprot id: F7B5B3
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

13616:PLIN2
gene id: 13616:PLIN2
uniprot id: F7EPX6
names: Similarity
messages: Belongs to the perilipin family.

13616:SMU1
gene id: 13616:SMU1
uniprot id: F7DWY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

13616:DONSON
gene id: 13616:DONSON
uniprot id: F6VIV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

13616:SHOX
gene id: 13616:SHOX
uniprot id: F6YBL9
names: Subcellular Location Annotation
messages: Nucleus

13616:IL2
gene id: 13616:IL2
uniprot id: A0A5F8GY47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

13616:CX3CR1
gene id: 13616:CX3CR1
uniprot id: F7CI96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:YWHAB
gene id: 13616:YWHAB
uniprot id: A0A5F8GSA5
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:LOC100012665
gene id: 13616:LOC100012665
uniprot id: F6PGZ4
names: Subcellular Location Annotation
messages: Membrane

13616:TMEM245
gene id: 13616:TMEM245
uniprot id: A0A5F8GGL3
uniprot id: F6PLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

13616:LIF
gene id: 13616:LIF
uniprot id: F7EE29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

13616:VN2R583
gene id: 13616:VN2R583
uniprot id: A0A5F8GN55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100024481
gene id: 13616:LOC100024481
uniprot id: F7F0L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FOXR1
gene id: 13616:FOXR1
uniprot id: F7GA66
names: Subcellular Location Annotation
messages: Nucleus

13616:PLN
gene id: 13616:PLN
uniprot id: F6V8P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

13616:ILVBL
gene id: 13616:ILVBL
uniprot id: F7ERP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

13616:PLPPR4
gene id: 13616:PLPPR4
uniprot id: F7D869
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:MRPL16
gene id: 13616:MRPL16
uniprot id: F7FXV3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

13616:TEKT3
gene id: 13616:TEKT3
uniprot id: F7FNQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

13616:LOC100019177
gene id: 13616:LOC100019177
uniprot id: F7AJJ0
names: Similarity
messages: Belongs to the S-100 family.

13616:LOC100021148
gene id: 13616:LOC100021148
uniprot id: F7AN22
names: Subcellular Location Annotation
messages: Membrane

13616:PLRG1
gene id: 13616:PLRG1
uniprot id: A0A5F8GXT6
uniprot id: F7G7S0
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

13616:CCNDBP1
gene id: 13616:CCNDBP1
uniprot id: A0A5F8GTB2
uniprot id: F6Z7U3
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

13616:VRK1
gene id: 13616:VRK1
uniprot id: F6QLF8
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:AKR1E2
gene id: 13616:AKR1E2
uniprot id: F7DXB7
names: Similarity
messages: Belongs to the aldo/keto reductase family.

13616:LOC100022852
gene id: 13616:LOC100022852
uniprot id: A0A5F8HKJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103095354
gene id: 13616:LOC103095354
uniprot id: F7F0X2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:TMEM43
gene id: 13616:TMEM43
uniprot id: F7EXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

13616:CHPT1
gene id: 13616:CHPT1
uniprot id: F7GFA6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

13616:LOC100031907
gene id: 13616:LOC100031907
uniprot id: F6XDY3
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:POLR2G
gene id: 13616:POLR2G
uniprot id: K7E561
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

13616:DUSP6
gene id: 13616:DUSP6
uniprot id: F7ENU0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

13616:MRGBP
gene id: 13616:MRGBP
uniprot id: F7FVJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

13616:GOT1
gene id: 13616:GOT1
uniprot id: F7GBD3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

13616:ALG8
gene id: 13616:ALG8
uniprot id: F6WKY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:NOX4
gene id: 13616:NOX4
uniprot id: F6Z703
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100028951
gene id: 13616:LOC100028951
uniprot id: F6R9L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:PDE7A
gene id: 13616:PDE7A
uniprot id: A0A5F8GWM4
uniprot id: F7ELV9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:ADCY2
gene id: 13616:ADCY2
uniprot id: F6V001
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:GATSL2
gene id: 13616:GATSL2
uniprot id: F6PTR3
names: Similarity
messages: Belongs to the GATS family.

13616:SHCBP1L
gene id: 13616:SHCBP1L
uniprot id: F6QUP0
names: Subcellular Location Annotation
messages: spindle

13616:NPY
gene id: 13616:NPY
uniprot id: F6VPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

13616:RFX1
gene id: 13616:RFX1
uniprot id: F7ALG0
names: Subcellular Location Annotation
messages: Nucleus

13616:NUS1
gene id: 13616:NUS1
uniprot id: F7CFL0
names: Similarity
messages: Belongs to the UPP synthase family.

13616:STXBP3
gene id: 13616:STXBP3
uniprot id: A0A5F8GMQ2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

13616:UBE2F
gene id: 13616:UBE2F
uniprot id: F7CUS8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:ZPBP2
gene id: 13616:ZPBP2
uniprot id: F7GKP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

13616:CDK1
gene id: 13616:CDK1
uniprot id: F6V3X3
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100012494
gene id: 13616:LOC100012494
uniprot id: F6T5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:UBE2N
gene id: 13616:UBE2N
uniprot id: F7FZL4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:IFT122
gene id: 13616:IFT122
uniprot id: A0A5F8GW83
uniprot id: F7FGI2
names: Subcellular Location Annotation
messages: cilium

13616:FOXP1
gene id: 13616:FOXP1
uniprot id: F7E578
names: Subcellular Location Annotation
messages: Nucleus

13616:MVB12B
gene id: 13616:MVB12B
uniprot id: A0A5F8GKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

13616:LPAR2
gene id: 13616:LPAR2
uniprot id: F6VRS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC7A4
gene id: 13616:SLC7A4
uniprot id: A0A5F8GKA4
names: Subcellular Location Annotation
messages: Membrane

13616:CXCR5
gene id: 13616:CXCR5
uniprot id: F7DTL3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:SLC17A5
gene id: 13616:SLC17A5
uniprot id: F7AG80
names: Subcellular Location Annotation
messages: Membrane

13616:ATP5G1
gene id: 13616:ATP5G1
uniprot id: A0A5F8GA93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

13616:GNG12
gene id: 13616:GNG12
uniprot id: F6SSS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:LOC100009948
gene id: 13616:LOC100009948
uniprot id: F7BR58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VN2R632
gene id: 13616:VN2R632
uniprot id: A0A5F8GH37
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:NFE2L1
gene id: 13616:NFE2L1
uniprot id: F7DHJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. CNC subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:TNMD
gene id: 13616:TNMD
uniprot id: F7BQF2
names: Similarity
messages: Belongs to the chondromodulin-1 family.

13616:S1PR4
gene id: 13616:S1PR4
uniprot id: F7EC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:LOC100618325
gene id: 13616:LOC100618325
uniprot id: A0A5F8GGA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC41A3
gene id: 13616:SLC41A3
uniprot id: A0A5F8G970
uniprot id: F7BLA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:FUT10
gene id: 13616:FUT10
uniprot id: F7FP77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

13616:TF
gene id: 13616:TF
uniprot id: F7C9Z1
names: Similarity
messages: Belongs to the transferrin family.

13616:LOC100028006
gene id: 13616:LOC100028006
uniprot id: A0A5F8H4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SNRPG
gene id: 13616:SNRPG
uniprot id: F6RHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

13616:SLC31A2
gene id: 13616:SLC31A2
uniprot id: A0A5F8H6I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

13616:TOP3B
gene id: 13616:TOP3B
uniprot id: F7FUS9
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

13616:TRHDE
gene id: 13616:TRHDE
uniprot id: A0A5F8G9Y3
names: Similarity
messages: Belongs to the peptidase M1 family.

13616:UBAC2
gene id: 13616:UBAC2
uniprot id: A0A5F8HE64
names: Subcellular Location Annotation
messages: Membrane

13616:SIAH2
gene id: 13616:SIAH2
uniprot id: F7DVK7
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

13616:CUL1
gene id: 13616:CUL1
uniprot id: F6T584
names: Similarity
messages: Belongs to the cullin family.

13616:LOC100028143
gene id: 13616:LOC100028143
uniprot id: F6TEL7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TULP4
gene id: 13616:TULP4
uniprot id: F7FNH2
names: Similarity
messages: Belongs to the TUB family.

13616:SPRY2
gene id: 13616:SPRY2
uniprot id: F7BBA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: ruffle membrane

13616:ALAS1
gene id: 13616:ALAS1
uniprot id: F7GEE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

13616:TMEM8A
gene id: 13616:TMEM8A
uniprot id: F7E6Q5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:IL15
gene id: 13616:IL15
uniprot id: A0A5F8G3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

13616:UHRF2
gene id: 13616:UHRF2
uniprot id: F6UK80
names: Subcellular Location Annotation
messages: Nucleus

13616:LIMS1
gene id: 13616:LIMS1
uniprot id: A0A5F8GRJ2
uniprot id: A0A5F8H5W4
uniprot id: F7E2C4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

13616:ZDHHC20
gene id: 13616:ZDHHC20
uniprot id: A0A5F8G2I7
uniprot id: F6XXZ8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:SLC39A2
gene id: 13616:SLC39A2
uniprot id: F6PG53
names: Subcellular Location Annotation
messages: Membrane

13616:TOMM22
gene id: 13616:TOMM22
uniprot id: F6QTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

13616:SGTA
gene id: 13616:SGTA
uniprot id: F7C205
names: Similarity
messages: Belongs to the SGT family.

13616:ATG13
gene id: 13616:ATG13
uniprot id: F7CFT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

13616:GNA11
gene id: 13616:GNA11
uniprot id: F7ECA6
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

13616:SAMM50
gene id: 13616:SAMM50
uniprot id: F6ZTF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

13616:MALSU1
gene id: 13616:MALSU1
uniprot id: F6ZF75
names: Similarity
messages: Belongs to the Iojap/RsfS family.

13616:LOC100022719
gene id: 13616:LOC100022719
uniprot id: F7DG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NDUFB8
gene id: 13616:NDUFB8
uniprot id: A0A5F8GSV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:LOC100027633
gene id: 13616:LOC100027633
uniprot id: F6Z758
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

13616:ACAD8
gene id: 13616:ACAD8
uniprot id: F7CGB6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:LOC100025055
gene id: 13616:LOC100025055
uniprot id: F7GIH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:WFIKKN1
gene id: 13616:WFIKKN1
uniprot id: F7D2F1
names: Similarity
messages: Belongs to the WFIKKN family.

13616:LOC100021467
gene id: 13616:LOC100021467
uniprot id: F7GHL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:LOC100617634
gene id: 13616:LOC100617634
uniprot id: A0A5F8GUW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PARP1
gene id: 13616:PARP1
uniprot id: F7FES2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

13616:SNF8
gene id: 13616:SNF8
uniprot id: F6YG55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

13616:USP13
gene id: 13616:USP13
uniprot id: F7G3T7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:DBNDD1
gene id: 13616:DBNDD1
uniprot id: A0A5F8GT25
names: Similarity
messages: Belongs to the dysbindin family.

13616:PKNOX1
gene id: 13616:PKNOX1
uniprot id: A0A5F8GKA7
uniprot id: F6QYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

13616:MOGAT3
gene id: 13616:MOGAT3
uniprot id: F7FKS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SIDT2
gene id: 13616:SIDT2
uniprot id: A0A5F8G8S2
uniprot id: A0A5F8GAD1
uniprot id: F6UB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

13616:NUDT19
gene id: 13616:NUDT19
uniprot id: A0A5F8GUK1
uniprot id: A0A5F8HE42
names: Similarity
messages: Belongs to the Nudix hydrolase family.

13616:CACNB1
gene id: 13616:CACNB1
uniprot id: A0A5F8G4K2
uniprot id: F6VFL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

13616:WDR45
gene id: 13616:WDR45
uniprot id: A0A5F8GT09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

13616:LOC103099492
gene id: 13616:LOC103099492
uniprot id: A0A5F8HDH8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:L3MBTL4
gene id: 13616:L3MBTL4
uniprot id: F7GLP9
names: Subcellular Location Annotation
messages: Nucleus

13616:TRMT6
gene id: 13616:TRMT6
uniprot id: F7AA51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

13616:VN2R555
gene id: 13616:VN2R555
uniprot id: A0A5F8GN76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC107649499
gene id: 13616:LOC107649499
uniprot id: A0A5F8H7R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

13616:TYRP1
gene id: 13616:TYRP1
uniprot id: F7FUN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

13616:PREP
gene id: 13616:PREP
uniprot id: F6ZWJ1
names: Similarity
messages: Belongs to the peptidase S9A family.

13616:ALOX5
gene id: 13616:ALOX5
uniprot id: F7FJV9
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PIH1D3
gene id: 13616:PIH1D3
uniprot id: F7DF68
names: Similarity
messages: Belongs to the PIH1 family.

13616:VPS53
gene id: 13616:VPS53
uniprot id: F6WN34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

13616:CENPT
gene id: 13616:CENPT
uniprot id: A0A5F8GK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

13616:CECR1
gene id: 13616:CECR1
uniprot id: F7CUH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

13616:DCAF13
gene id: 13616:DCAF13
uniprot id: F7FHD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

13616:LOC100017853
gene id: 13616:LOC100017853
uniprot id: A0A5F8HD68
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:YY1
gene id: 13616:YY1
uniprot id: A0A5F8GN11
uniprot id: F7BM88
names: Similarity
messages: Belongs to the YY transcription factor family.

13616:DENR
gene id: 13616:DENR
uniprot id: A0A5F8GGX6
names: Similarity
messages: Belongs to the DENR family.

13616:TBCCD1
gene id: 13616:TBCCD1
uniprot id: F6ZJD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

13616:LOC100019634
gene id: 13616:LOC100019634
uniprot id: F6YRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RAB29
gene id: 13616:RAB29
uniprot id: F6SPF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

13616:CKMT1A
gene id: 13616:CKMT1A
uniprot id: F7DJD6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

13616:NKX2-2
gene id: 13616:NKX2-2
uniprot id: F7B516
names: Subcellular Location Annotation
messages: Nucleus

13616:OSGEPL1
gene id: 13616:OSGEPL1
uniprot id: A0A5F8H593
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

13616:PITX1
gene id: 13616:PITX1
uniprot id: A0A5F8H975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:HSPB2
gene id: 13616:HSPB2
uniprot id: F7ATU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

13616:LRRC8D
gene id: 13616:LRRC8D
uniprot id: A0A5F8HD08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

13616:PARP16
gene id: 13616:PARP16
uniprot id: A0A5F8H951
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:LOC100017394
gene id: 13616:LOC100017394
uniprot id: F6Z9R8
names: Similarity
messages: Belongs to the centrin family.

13616:GLO1
gene id: 13616:GLO1
uniprot id: F7ECV7
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

13616:PDE1A
gene id: 13616:PDE1A
uniprot id: A0A5F8GTK4
uniprot id: A0A5F8H6Y5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:DHPS
gene id: 13616:DHPS
uniprot id: F6PGR5
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

13616:PIANP
gene id: 13616:PIANP
uniprot id: F7FFB9
names: Subcellular Location Annotation
messages: Membrane

13616:FER
gene id: 13616:FER
uniprot id: A0A5F8G8M2
uniprot id: F7FIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

13616:LOC100010821
gene id: 13616:LOC100010821
uniprot id: F6R929
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

13616:GSDMD
gene id: 13616:GSDMD
uniprot id: F6WZ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

13616:CES2.1
gene id: 13616:CES2.1
uniprot id: B2BSF5
uniprot id: F7C870
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

13616:CHAF1B
gene id: 13616:CHAF1B
uniprot id: F6RJB6
names: Subcellular Location Annotation
messages: Nucleus

13616:SMDT1
gene id: 13616:SMDT1
uniprot id: F6UFP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

13616:CD40LG
gene id: 13616:CD40LG
uniprot id: A0A5F8GKW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

13616:LOC100025235
gene id: 13616:LOC100025235
uniprot id: F7GFJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

13616:RPS6KA2
gene id: 13616:RPS6KA2
uniprot id: A0A5F8GFF9
uniprot id: F7FRY0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

13616:TMEM186
gene id: 13616:TMEM186
uniprot id: F6QE97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

13616:LOC100022881
gene id: 13616:LOC100022881
uniprot id: A0A5F8GQ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MTERF2
gene id: 13616:MTERF2
uniprot id: F7BBD3
names: Similarity
messages: Belongs to the mTERF family.

13616:CNOT1
gene id: 13616:CNOT1
uniprot id: F6TR11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

13616:RASSF1
gene id: 13616:RASSF1
uniprot id: A0A5F8H5U5
names: Subcellular Location Annotation
messages: cytoskeleton

13616:LOC100017544
gene id: 13616:LOC100017544
uniprot id: A0A5F8G7L7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:CNOT9
gene id: 13616:CNOT9
uniprot id: F6T3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

13616:AES
gene id: 13616:AES
uniprot id: F7ECH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

13616:ADCK5
gene id: 13616:ADCK5
uniprot id: F7G7M7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

13616:LOC100024470
gene id: 13616:LOC100024470
uniprot id: F7FFX8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

13616:GDF1
gene id: 13616:GDF1
uniprot id: A0A5F8G6L7
names: Similarity
messages: Belongs to the TGF-beta family.

13616:MLH3
gene id: 13616:MLH3
uniprot id: A0A5F8HIQ8
uniprot id: F6ZUC5
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

13616:FAM13B
gene id: 13616:FAM13B
uniprot id: A0A5F8GHS6
uniprot id: A0A5F8GN33
uniprot id: A0A5F8GTD7
uniprot id: F6YH59
names: Similarity
messages: Belongs to the FAM13 family.

13616:PARPBP
gene id: 13616:PARPBP
uniprot id: A0A5F8G9K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

13616:NXPH3
gene id: 13616:NXPH3
uniprot id: A0A5F8HFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

13616:ATG12
gene id: 13616:ATG12
uniprot id: F6UDZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

13616:JPH2
gene id: 13616:JPH2
uniprot id: F7FLU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

13616:HGD
gene id: 13616:HGD
uniprot id: F6PGC2
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

13616:MAP4K3
gene id: 13616:MAP4K3
uniprot id: A0A5F8GEP6
uniprot id: A0A5F8GT03
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

13616:EEF1D
gene id: 13616:EEF1D
uniprot id: K7E448
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

13616:LOC100017283
gene id: 13616:LOC100017283
uniprot id: F6TJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:LOC100032364
gene id: 13616:LOC100032364
uniprot id: F6XPY0
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

13616:MLF1
gene id: 13616:MLF1
uniprot id: A0A5F8GTJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

13616:SEC61A1
gene id: 13616:SEC61A1
uniprot id: F7D5U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:WHAMM
gene id: 13616:WHAMM
uniprot id: F7AXA6
names: Subcellular Location Annotation
messages: Membrane

13616:NUP188
gene id: 13616:NUP188
uniprot id: A0A5F8GD79
uniprot id: F7GEX1
names: Subcellular Location Annotation
messages: nuclear pore complex

13616:USP9X
gene id: 13616:USP9X
uniprot id: F6UID4
names: Similarity
messages: Belongs to the peptidase C19 family.

13616:BABAM1
gene id: 13616:BABAM1
uniprot id: F7FHA1
names: Subcellular Location Annotation
messages: Nucleus

13616:C6H16orf13
gene id: 13616:C6H16orf13
uniprot id: A0A5F8H9S4
names: Similarity
messages: Belongs to the UPF0585 family.

13616:MRPL28
gene id: 13616:MRPL28
uniprot id: F7E6R6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

13616:PPP2R3C
gene id: 13616:PPP2R3C
uniprot id: F7GKQ5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:HOXA5
gene id: 13616:HOXA5
uniprot id: F6UA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:EFHC2
gene id: 13616:EFHC2
uniprot id: F6UIX5
names: Subcellular Location Annotation
messages: cilium axoneme

13616:MOCS2
gene id: 13616:MOCS2
uniprot id: F6RWP4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

13616:PRDX6
gene id: 13616:PRDX6
uniprot id: F7CMG3
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

13616:RPRD1A
gene id: 13616:RPRD1A
uniprot id: A0A5F8HKZ2
uniprot id: F6QN59
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

13616:ALPL
gene id: 13616:ALPL
uniprot id: F7EGD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

13616:EIF2S2
gene id: 13616:EIF2S2
uniprot id: F7EJH2
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

13616:OTC
gene id: 13616:OTC
uniprot id: F6UHY3
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

13616:LIN28B
gene id: 13616:LIN28B
uniprot id: A0A5F8GUV7
uniprot id: A0A5F8GZQ7
uniprot id: A0A5F8HHJ1
uniprot id: F6ZWF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

13616:PGLS
gene id: 13616:PGLS
uniprot id: F6SVN1
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

13616:MMP14
gene id: 13616:MMP14
uniprot id: F7E6W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Cytoplasm
messages: Melanosome

13616:RBBP5
gene id: 13616:RBBP5
uniprot id: F6RMK8
names: Subcellular Location Annotation
messages: Nucleus

13616:SPC25
gene id: 13616:SPC25
uniprot id: F7BJE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

13616:OTX2
gene id: 13616:OTX2
uniprot id: A0A5F8GEK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:PKM
gene id: 13616:PKM
uniprot id: A0A5F8GJZ6
uniprot id: F6WGC5
names: Similarity
messages: Belongs to the pyruvate kinase family.

13616:LOC100025761
gene id: 13616:LOC100025761
uniprot id: F6VK86
names: Similarity
messages: Belongs to the adenylate kinase family.

13616:PARP11
gene id: 13616:PARP11
uniprot id: F6PTG4
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:SRMS
gene id: 13616:SRMS
uniprot id: F6XJB6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:APOE
gene id: 13616:APOE
uniprot id: A0A5F8HC70
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

13616:ATP6V0E2
gene id: 13616:ATP6V0E2
uniprot id: A0A5F8H893
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:NOL6
gene id: 13616:NOL6
uniprot id: F6ZJX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

13616:TAF6L
gene id: 13616:TAF6L
uniprot id: F7D588
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

13616:GRIN3A
gene id: 13616:GRIN3A
uniprot id: F7AUG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:LOC100018407
gene id: 13616:LOC100018407
uniprot id: A0A5F8GA63
names: Subcellular Location Annotation
messages: Nucleus

13616:NELFCD
gene id: 13616:NELFCD
uniprot id: F6ZD99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

13616:LOC100017089
gene id: 13616:LOC100017089
uniprot id: F6XDL1
names: Similarity
messages: Belongs to the peptidase A1 family.

13616:PREPL
gene id: 13616:PREPL
uniprot id: A0A5F8HHU7
names: Similarity
messages: Belongs to the peptidase S9A family.

13616:BBOX1
gene id: 13616:BBOX1
uniprot id: F7BLG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

13616:HS3ST2
gene id: 13616:HS3ST2
uniprot id: A0A5F8GST9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:NAP1L4
gene id: 13616:NAP1L4
uniprot id: A0A5F8GBE0
uniprot id: A0A5F8HAQ3
uniprot id: F6XTV9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

13616:ANAPC16
gene id: 13616:ANAPC16
uniprot id: F6S1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

13616:SLC4A10
gene id: 13616:SLC4A10
uniprot id: A0A5F8G5N6
uniprot id: A0A5F8GT71
uniprot id: A0A5F8H6Z8
uniprot id: F7EC31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:APPL2
gene id: 13616:APPL2
uniprot id: F6RII3
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

13616:CCDC67
gene id: 13616:CCDC67
uniprot id: A0A5F8GA50
uniprot id: A0A5F8GVV7
uniprot id: F6ZGK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

13616:NIPA2
gene id: 13616:NIPA2
uniprot id: F6X4W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:TYW1
gene id: 13616:TYW1
uniprot id: F6TJ39
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

13616:LYVE1
gene id: 13616:LYVE1
uniprot id: F7AL98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CRTC1
gene id: 13616:CRTC1
uniprot id: A0A5F8GMY9
uniprot id: A0A5F8HFZ2
uniprot id: F7C6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

13616:ARGLU1
gene id: 13616:ARGLU1
uniprot id: F7FHF8
names: Similarity
messages: Belongs to the UPF0430 family.

13616:TMEM135
gene id: 13616:TMEM135
uniprot id: F6VVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

13616:PKD1
gene id: 13616:PKD1
uniprot id: F6YV18
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100010706
gene id: 13616:LOC100010706
uniprot id: F6YIL8
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

13616:SDHA
gene id: 13616:SDHA
uniprot id: F6TAP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

13616:MAP3K10
gene id: 13616:MAP3K10
uniprot id: F7CPB8
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

13616:CHD8
gene id: 13616:CHD8
uniprot id: F7FS88
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

13616:BCDIN3D
gene id: 13616:BCDIN3D
uniprot id: A0A5F8HB75
names: Similarity
messages: Belongs to the methyltransferase superfamily.

13616:ACP5
gene id: 13616:ACP5
uniprot id: F7DGU8
names: Cofactor
messages: Binds 2 iron ions per subunit.

13616:PAM
gene id: 13616:PAM
uniprot id: A0A5F8G7W8
uniprot id: A0A5F8H1V1
uniprot id: F6SHA5
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

13616:TWF2
gene id: 13616:TWF2
uniprot id: A0A5F8GYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

13616:GALK1
gene id: 13616:GALK1
uniprot id: F7BKK7
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

13616:HSPB3
gene id: 13616:HSPB3
uniprot id: A0A5F8HJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

13616:ABRACL
gene id: 13616:ABRACL
uniprot id: F6SM16
names: Similarity
messages: Belongs to the costars family.

13616:LHFPL5
gene id: 13616:LHFPL5
uniprot id: F6X7Q0
names: Subcellular Location Annotation
messages: Membrane

13616:RPL11
gene id: 13616:RPL11
uniprot id: F7DD44
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

13616:SNX10
gene id: 13616:SNX10
uniprot id: A0A5F8HJX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

13616:ATP5L
gene id: 13616:ATP5L
uniprot id: A0A5F8GEH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

13616:TATDN3
gene id: 13616:TATDN3
uniprot id: A0A5F8GEE7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

13616:TAF6
gene id: 13616:TAF6
uniprot id: F6TDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

13616:HYAL2
gene id: 13616:HYAL2
uniprot id: F7FU16
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

13616:MANBA
gene id: 13616:MANBA
uniprot id: A0A5F8G3D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

13616:VWC2L
gene id: 13616:VWC2L
uniprot id: F7FEN3
names: Subcellular Location Annotation
messages: Synapse

13616:LOC100028244
gene id: 13616:LOC100028244
uniprot id: F6WRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

13616:UBIAD1
gene id: 13616:UBIAD1
uniprot id: F7E5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

13616:TMSB4X
gene id: 13616:TMSB4X
uniprot id: F7ENP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:BTAF1
gene id: 13616:BTAF1
uniprot id: F7DH73
names: Subcellular Location Annotation
messages: Nucleus

13616:FAM110B
gene id: 13616:FAM110B
uniprot id: F7B486
names: Similarity
messages: Belongs to the FAM110 family.

13616:CCNE2
gene id: 13616:CCNE2
uniprot id: F6UFV2
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

13616:GDF3
gene id: 13616:GDF3
uniprot id: F7AL60
names: Similarity
messages: Belongs to the TGF-beta family.

13616:TMEM199
gene id: 13616:TMEM199
uniprot id: F6QU23
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CREB5
gene id: 13616:CREB5
uniprot id: A0A5F8HC91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

13616:CASP14
gene id: 13616:CASP14
uniprot id: A5HAU7
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:C1H10orf53
gene id: 13616:C1H10orf53
uniprot id: F6TCD6
names: Similarity
messages: Belongs to the UPF0728 family.

13616:THRSP
gene id: 13616:THRSP
uniprot id: F7GGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

13616:FAM105A
gene id: 13616:FAM105A
uniprot id: F6PMI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

13616:LOC100012489
gene id: 13616:LOC100012489
uniprot id: F7A9N5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

13616:LOC100619366
gene id: 13616:LOC100619366
uniprot id: F6YPS6
names: Similarity
messages: Belongs to the intermediate filament family.

13616:KCNA6
gene id: 13616:KCNA6
uniprot id: F7AL46
names: Subcellular Location Annotation
messages: Membrane

13616:BAG6
gene id: 13616:BAG6
uniprot id: A0A5F8G5L2
uniprot id: A0A5F8HL30
uniprot id: F6VB03
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

13616:HDAC2
gene id: 13616:HDAC2
uniprot id: F6YIM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

13616:SOST
gene id: 13616:SOST
uniprot id: A0A5F8GCV4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

13616:KBTBD8
gene id: 13616:KBTBD8
uniprot id: F7EYU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

13616:FMOD
gene id: 13616:FMOD
uniprot id: F7DPP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

13616:CSTB
gene id: 13616:CSTB
uniprot id: F6W0H8
names: Similarity
messages: Belongs to the cystatin family.

13616:ING4
gene id: 13616:ING4
uniprot id: A0A5F8H269
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:UPK1B
gene id: 13616:UPK1B
uniprot id: F7B797
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

13616:LOC103098338
gene id: 13616:LOC103098338
uniprot id: F7E383
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:IP6K3
gene id: 13616:IP6K3
uniprot id: F6QKC1
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

13616:ZPBP
gene id: 13616:ZPBP
uniprot id: F6YX37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

13616:SNX20
gene id: 13616:SNX20
uniprot id: F7FBP4
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

13616:DSC2
gene id: 13616:DSC2
uniprot id: A0A5F8GN48
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

13616:GNG4
gene id: 13616:GNG4
uniprot id: K7E376
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:LOC100024593
gene id: 13616:LOC100024593
uniprot id: F6PYX9
names: Similarity
messages: Belongs to the serpin family.

13616:CHMP6
gene id: 13616:CHMP6
uniprot id: A0A5F8GJB8
names: Similarity
messages: Belongs to the SNF7 family.

13616:GNPAT
gene id: 13616:GNPAT
uniprot id: A0A5F8GDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

13616:FGFR4
gene id: 13616:FGFR4
uniprot id: F7C211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:DDIT4
gene id: 13616:DDIT4
uniprot id: F6S0G1
names: Similarity
messages: Belongs to the DDIT4 family.

13616:DNAJB14
gene id: 13616:DNAJB14
uniprot id: F7DKI6
names: Subcellular Location Annotation
messages: Membrane

13616:EDA
gene id: 13616:EDA
uniprot id: F6UN90
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:MVP
gene id: 13616:MVP
uniprot id: A0A5F8GFC1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

13616:EPHA7
gene id: 13616:EPHA7
uniprot id: F7CWR4
names: Subcellular Location Annotation
messages: Membrane

13616:PRDM5
gene id: 13616:PRDM5
uniprot id: F7GB24
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100032596
gene id: 13616:LOC100032596
uniprot id: F7G5S9
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:XPA
gene id: 13616:XPA
uniprot id: F6TZJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

13616:LMX1B
gene id: 13616:LMX1B
uniprot id: F6TAA3
names: Subcellular Location Annotation
messages: Nucleus

13616:CALHM2
gene id: 13616:CALHM2
uniprot id: F7F446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:AVPR1A
gene id: 13616:AVPR1A
uniprot id: F6UMG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

13616:GCG
gene id: 13616:GCG
uniprot id: F7F3N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

13616:ANXA6
gene id: 13616:ANXA6
uniprot id: F6TXS8
uniprot id: F6YX46
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

13616:SQSTM1
gene id: 13616:SQSTM1
uniprot id: A0A5F8GH66
uniprot id: F6ZJ90
names: Subcellular Location Annotation
messages: autophagosome

13616:LOC103095221
gene id: 13616:LOC103095221
uniprot id: F7FXP6
names: Similarity
messages: Belongs to the MS4A family.

13616:CD164
gene id: 13616:CD164
uniprot id: F7BUT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

13616:IPO5
gene id: 13616:IPO5
uniprot id: F7FFK8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:HRH2
gene id: 13616:HRH2
uniprot id: A0A5F8H2U8
uniprot id: F6YL33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100032991
gene id: 13616:LOC100032991
uniprot id: F7CND5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TRDMT1
gene id: 13616:TRDMT1
uniprot id: F6WAN0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

13616:NECAP2
gene id: 13616:NECAP2
uniprot id: F6PIG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

13616:YES1
gene id: 13616:YES1
uniprot id: F7G374
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:RET
gene id: 13616:RET
uniprot id: F7G7S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

13616:TRMU
gene id: 13616:TRMU
uniprot id: F7DWM5
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

13616:UBLCP1
gene id: 13616:UBLCP1
uniprot id: F6YKB6
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

13616:DNMBP
gene id: 13616:DNMBP
uniprot id: A0A5F8GVN5
uniprot id: F6XNN0
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: Synapse
messages: cytoskeleton

13616:NKX3-1
gene id: 13616:NKX3-1
uniprot id: F7G683
names: Subcellular Location Annotation
messages: Nucleus

13616:TRIP12
gene id: 13616:TRIP12
uniprot id: A0A5F8GRC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

13616:VN2R553
gene id: 13616:VN2R553
uniprot id: A0A5F8HLZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:UBE2G1
gene id: 13616:UBE2G1
uniprot id: F7G2B2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:LHX9
gene id: 13616:LHX9
uniprot id: A0A5F8GW30
uniprot id: F6T103
names: Subcellular Location Annotation
messages: Nucleus

13616:UPP1
gene id: 13616:UPP1
uniprot id: F7C5E7
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

13616:FERMT2
gene id: 13616:FERMT2
uniprot id: F7BNK8
names: Similarity
messages: Belongs to the kindlin family.

13616:MTMR6
gene id: 13616:MTMR6
uniprot id: A0A5F8GXW6
uniprot id: F7CX78
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:CTSB
gene id: 13616:CTSB
uniprot id: F7ALZ4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:ALAD
gene id: 13616:ALAD
uniprot id: F6SVR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

13616:LOC100031971
gene id: 13616:LOC100031971
uniprot id: F7G922
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100031975
gene id: 13616:LOC100031975
uniprot id: F6TYS0
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100024398
gene id: 13616:LOC100024398
uniprot id: A0A5F8HF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GAR1
gene id: 13616:GAR1
uniprot id: F7E2W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

13616:ABCG1
gene id: 13616:ABCG1
uniprot id: F6QZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

13616:LOC100022185
gene id: 13616:LOC100022185
uniprot id: F7BVK1
names: Subcellular Location Annotation
messages: Nucleus

13616:ADRA1B
gene id: 13616:ADRA1B
uniprot id: F7CKY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

13616:TUBD1
gene id: 13616:TUBD1
uniprot id: A0A5F8G4K3
uniprot id: F6V570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

13616:SH3YL1
gene id: 13616:SH3YL1
uniprot id: A0A5F8H8M0
uniprot id: F6XJ09
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

13616:GTF2B
gene id: 13616:GTF2B
uniprot id: F6PMC9
names: Similarity
messages: Belongs to the TFIIB family.

13616:SCN3A
gene id: 13616:SCN3A
uniprot id: A0A5F8HFU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

13616:SFPQ
gene id: 13616:SFPQ
uniprot id: A0A5F8G4R8
uniprot id: A0A5F8GPT0
names: Subcellular Location Annotation
messages: Nucleus speckle

13616:EN1
gene id: 13616:EN1
uniprot id: F7FKR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

13616:GOSR2
gene id: 13616:GOSR2
uniprot id: A0A5F8H7B8
uniprot id: F7E5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

13616:KAT7
gene id: 13616:KAT7
uniprot id: F7DHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

13616:CD14
gene id: 13616:CD14
uniprot id: F6SDH5
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

13616:PQLC1
gene id: 13616:PQLC1
uniprot id: A0A5F8HDI0
uniprot id: F7B9T8
names: Subcellular Location Annotation
messages: Membrane

13616:SPDYA
gene id: 13616:SPDYA
uniprot id: A0A5F8H7N2
names: Similarity
messages: Belongs to the Speedy/Ringo family.

13616:GPR4
gene id: 13616:GPR4
uniprot id: A0A5F8H9J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TSTA3
gene id: 13616:TSTA3
uniprot id: F6ZAF0
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

13616:NRXN1
gene id: 13616:NRXN1
uniprot id: A0A5F8GGY5
uniprot id: F7BZM4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LIPC
gene id: 13616:LIPC
uniprot id: A0A5F8G1W6
uniprot id: F6PXQ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:RPL13
gene id: 13616:RPL13
uniprot id: F7ACE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

13616:LOC100010438
gene id: 13616:LOC100010438
uniprot id: F6TF19
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:PAQR8
gene id: 13616:PAQR8
uniprot id: F6Z2L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:KPNA6
gene id: 13616:KPNA6
uniprot id: A0A5F8GFC7
uniprot id: F7E1F4
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:CASP18
gene id: 13616:CASP18
uniprot id: A9YDV7
uniprot id: K7E316
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:LOC100020741
gene id: 13616:LOC100020741
uniprot id: A0A5F8GCA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RPL9
gene id: 13616:RPL9
uniprot id: F7AQ39
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

13616:DDC
gene id: 13616:DDC
uniprot id: A0A5F8H514
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

13616:CAPN10
gene id: 13616:CAPN10
uniprot id: F7CY16
names: Similarity
messages: Belongs to the peptidase C2 family.

13616:TMEM206
gene id: 13616:TMEM206
uniprot id: F6Q562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

13616:SPSB4
gene id: 13616:SPSB4
uniprot id: F7B312
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

13616:JRKL
gene id: 13616:JRKL
uniprot id: F7GFT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

13616:LOC100010714
gene id: 13616:LOC100010714
uniprot id: F7B277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:S100Z
gene id: 13616:S100Z
uniprot id: F6WNQ1
names: Similarity
messages: Belongs to the S-100 family.

13616:LOC103096977
gene id: 13616:LOC103096977
uniprot id: A0A5F8GAN6
names: Similarity
messages: Belongs to the BLOC1S2 family.

13616:MGST1
gene id: 13616:MGST1
uniprot id: F7FGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

13616:REV3L
gene id: 13616:REV3L
uniprot id: A0A5F8GU36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

13616:EIF3B
gene id: 13616:EIF3B
uniprot id: F6SZX9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: The RRM domain mediates interaction with EIF3J.

13616:MAPK1IP1L
gene id: 13616:MAPK1IP1L
uniprot id: F7FT59
names: Similarity
messages: Belongs to the MISS family.

13616:UGDH
gene id: 13616:UGDH
uniprot id: F7AQE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

13616:LOC100029165
gene id: 13616:LOC100029165
uniprot id: F7FZW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IDH3A
gene id: 13616:IDH3A
uniprot id: F6TJ83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

13616:RBPJ
gene id: 13616:RBPJ
uniprot id: A0A5F8G8L8
uniprot id: A0A5F8GAZ5
uniprot id: A0A5F8H915
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

13616:monDomV1R1237
gene id: 13616:monDomV1R1237
uniprot id: F7GES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RRP1B
gene id: 13616:RRP1B
uniprot id: F6W0J2
names: Similarity
messages: Belongs to the RRP1 family.

13616:LOC100618822
gene id: 13616:LOC100618822
uniprot id: A0A5F8G951
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:BTG2
gene id: 13616:BTG2
uniprot id: A0A5F8GS31
names: Similarity
messages: Belongs to the BTG family.

13616:AATF
gene id: 13616:AATF
uniprot id: F7EGI5
names: Similarity
messages: Belongs to the AATF family.

13616:ST6GAL1
gene id: 13616:ST6GAL1
uniprot id: E4ZFH4
uniprot id: F6YWA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:GTF3C5
gene id: 13616:GTF3C5
uniprot id: A0A5F8H6L2
names: Subcellular Location Annotation
messages: Nucleus

13616:FAM57B
gene id: 13616:FAM57B
uniprot id: F7DGI0
names: Subcellular Location Annotation
messages: Membrane

13616:CDKN3
gene id: 13616:CDKN3
uniprot id: A0A5F8HE70
uniprot id: F6UZN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

13616:MCM2
gene id: 13616:MCM2
uniprot id: F6ZG72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

13616:SEMA4A
gene id: 13616:SEMA4A
uniprot id: A0A5F8G4H1
uniprot id: F6VN06
names: Similarity
messages: Belongs to the semaphorin family.

13616:CSAD
gene id: 13616:CSAD
uniprot id: F7G221
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

13616:YBEY
gene id: 13616:YBEY
uniprot id: F7GEX4
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

13616:SLC16A13
gene id: 13616:SLC16A13
uniprot id: F6ZJR4
names: Subcellular Location Annotation
messages: Membrane

13616:NAT10
gene id: 13616:NAT10
uniprot id: F6VCE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

13616:TUBB1
gene id: 13616:TUBB1
uniprot id: F6ZCX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:LOC100015374
gene id: 13616:LOC100015374
uniprot id: F7CLT7
names: Similarity
messages: Belongs to the intermediate filament family.

13616:C7H3orf58
gene id: 13616:C7H3orf58
uniprot id: F6TJE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

13616:ATP6AP1
gene id: 13616:ATP6AP1
uniprot id: F7CAZ5
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

13616:SERPINB5
gene id: 13616:SERPINB5
uniprot id: F7DMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

13616:VN2R590
gene id: 13616:VN2R590
uniprot id: H9H846
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:FXR2
gene id: 13616:FXR2
uniprot id: F6XS15
names: Similarity
messages: Belongs to the FMR1 family.

13616:PRPH2
gene id: 13616:PRPH2
uniprot id: F7BLI0
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

13616:PSD3
gene id: 13616:PSD3
uniprot id: A0A5F8GLW2
names: Subcellular Location Annotation
messages: ruffle membrane

13616:LOC100016275
gene id: 13616:LOC100016275
uniprot id: F6RQ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:CNIH4
gene id: 13616:CNIH4
uniprot id: F7DP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

13616:FZD8
gene id: 13616:FZD8
uniprot id: F7CDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

13616:NAALAD2
gene id: 13616:NAALAD2
uniprot id: A0A5F8GWN8
uniprot id: F7EFS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

13616:POLD3
gene id: 13616:POLD3
uniprot id: F6X936
names: Subcellular Location Annotation
messages: Nucleus

13616:TMCC1
gene id: 13616:TMCC1
uniprot id: F6QA24
names: Similarity
messages: Belongs to the TEX28 family.

13616:LIN9
gene id: 13616:LIN9
uniprot id: F6ZUZ8
names: Similarity
messages: Belongs to the lin-9 family.

13616:PSMD6
gene id: 13616:PSMD6
uniprot id: F6PLG4
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

13616:PIK3CA
gene id: 13616:PIK3CA
uniprot id: F7G3I5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

13616:SPATS2L
gene id: 13616:SPATS2L
uniprot id: F6PMD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

13616:NPHS2
gene id: 13616:NPHS2
uniprot id: F7BSK5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

13616:PPP2R2C
gene id: 13616:PPP2R2C
uniprot id: A0A5F8H9I6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

13616:LOC103099919
gene id: 13616:LOC103099919
uniprot id: A0A5F8GQL3
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

13616:ZNF277
gene id: 13616:ZNF277
uniprot id: F6ZR18
names: Similarity
messages: Belongs to the ZNF277 family.

13616:PKD2
gene id: 13616:PKD2
uniprot id: A0A5F8GBJ0
uniprot id: F7ANU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

13616:MARVELD1
gene id: 13616:MARVELD1
uniprot id: F7CNW2
names: Subcellular Location Annotation
messages: Membrane

13616:NELL1
gene id: 13616:NELL1
uniprot id: A0A5F8HGW1
uniprot id: F7EDR3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NEDD8
gene id: 13616:NEDD8
uniprot id: F6T1M0
names: Similarity
messages: Belongs to the ubiquitin family.

13616:LOC100030497
gene id: 13616:LOC100030497
uniprot id: A0A5F8GAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

13616:HS3ST6
gene id: 13616:HS3ST6
uniprot id: F6YUM6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:KCNA7
gene id: 13616:KCNA7
uniprot id: A0A5F8GB06
names: Subcellular Location Annotation
messages: Membrane

13616:GDNF
gene id: 13616:GDNF
uniprot id: F7FWY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

13616:monDomV1R1212
gene id: 13616:monDomV1R1212
uniprot id: A0A5F8G9T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HDHD2
gene id: 13616:HDHD2
uniprot id: A0A5F8GTJ0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

13616:MCU
gene id: 13616:MCU
uniprot id: A0A5F8GW32
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

13616:SENP3
gene id: 13616:SENP3
uniprot id: A0A5F8G7P8
uniprot id: A0A5F8H0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

13616:FAM189A2
gene id: 13616:FAM189A2
uniprot id: F7E297
names: Similarity
messages: Belongs to the ENTREP family.

13616:RIN2
gene id: 13616:RIN2
uniprot id: F6XCT8
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

13616:SYNDIG1
gene id: 13616:SYNDIG1
uniprot id: F7CAE5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:LOC100027189
gene id: 13616:LOC100027189
uniprot id: F7FK22
names: Subcellular Location Annotation
messages: Membrane

13616:CCDC126
gene id: 13616:CCDC126
uniprot id: A0A5F8H3D2
names: Subcellular Location Annotation
messages: Secreted

13616:CEP170B
gene id: 13616:CEP170B
uniprot id: F6TS07
names: Similarity
messages: Belongs to the CEP170 family.

13616:KEG11 p03
gene id: 13616:KEG11_p03
uniprot id: Q65CI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

13616:CHST12
gene id: 13616:CHST12
uniprot id: F6XP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:FOXJ3
gene id: 13616:FOXJ3
uniprot id: A0A5F8HI89
uniprot id: F6WWW5
names: Subcellular Location Annotation
messages: Nucleus

13616:ENTPD6
gene id: 13616:ENTPD6
uniprot id: F7GCQ3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:LOC100018896
gene id: 13616:LOC100018896
uniprot id: F6V6W6
names: Subcellular Location Annotation
messages: Membrane

13616:INTS8
gene id: 13616:INTS8
uniprot id: F6Q8M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

13616:MMP27
gene id: 13616:MMP27
uniprot id: F6X261
names: Similarity
messages: Belongs to the peptidase M10A family.

13616:TMEM45A
gene id: 13616:TMEM45A
uniprot id: F6UIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

13616:ITPRIP
gene id: 13616:ITPRIP
uniprot id: F7FAS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Cell membrane
messages: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
messages: Membrane
messages: Nucleus outer membrane

13616:LOC100022521
gene id: 13616:LOC100022521
uniprot id: F6SPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103093843
gene id: 13616:LOC103093843
uniprot id: F7BK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:ARPC2
gene id: 13616:ARPC2
uniprot id: A0A5F8H9Z5
uniprot id: F6VZK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

13616:TSPAN14
gene id: 13616:TSPAN14
uniprot id: F7E616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:GPN2
gene id: 13616:GPN2
uniprot id: A0A5F8GM25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

13616:DLX1
gene id: 13616:DLX1
uniprot id: F7BRI6
names: Subcellular Location Annotation
messages: Nucleus

13616:CASP16
gene id: 13616:CASP16
uniprot id: F7BTN7
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:MTX1
gene id: 13616:MTX1
uniprot id: F6V427
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

13616:TGIF1
gene id: 13616:TGIF1
uniprot id: A0A5F8HH57
names: Subcellular Location Annotation
messages: Nucleus

13616:CTDP1
gene id: 13616:CTDP1
uniprot id: F7B931
names: Subcellular Location Annotation
messages: Nucleus

13616:CD53
gene id: 13616:CD53
uniprot id: A0A5F8HE98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:IFT20
gene id: 13616:IFT20
uniprot id: F6RDW6
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

13616:LOC100021363
gene id: 13616:LOC100021363
uniprot id: F6PZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TRMT13
gene id: 13616:TRMT13
uniprot id: F7B009
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

13616:RUVBL1
gene id: 13616:RUVBL1
uniprot id: F7CL07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

13616:DHRS7B
gene id: 13616:DHRS7B
uniprot id: A0A5F8GVW3
uniprot id: A0A5F8H473
uniprot id: F7BCU1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:KCNU1
gene id: 13616:KCNU1
uniprot id: A0A5F8GWM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PHB2
gene id: 13616:PHB2
uniprot id: A0A5F8G2V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

13616:LOC100024614
gene id: 13616:LOC100024614
uniprot id: F6SC37
names: Similarity
messages: Belongs to the serpin family.

13616:MAATS1
gene id: 13616:MAATS1
uniprot id: F6PGW3
names: Similarity
messages: Belongs to the CFAP91 family.

13616:LOC100023588
gene id: 13616:LOC100023588
uniprot id: F6Q1P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:REXO4
gene id: 13616:REXO4
uniprot id: F7DY31
names: Similarity
messages: Belongs to the REXO4 family.

13616:SIGMAR1
gene id: 13616:SIGMAR1
uniprot id: F7GIA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

13616:HOXD12
gene id: 13616:HOXD12
uniprot id: F6ZN53
names: Subcellular Location Annotation
messages: Nucleus

13616:AKIRIN1
gene id: 13616:AKIRIN1
uniprot id: F6Y5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

13616:FAM173A
gene id: 13616:FAM173A
uniprot id: A0A5F8GHD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

13616:VN2R635
gene id: 13616:VN2R635
uniprot id: A0A5F8HIB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC103103995
gene id: 13616:LOC103103995
uniprot id: K7E1P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:ACTN4
gene id: 13616:ACTN4
uniprot id: A0A5F8GFJ7
uniprot id: A0A5F8GZK7
uniprot id: A0A5F8H0X0
uniprot id: F7DTH8
names: Similarity
messages: Belongs to the alpha-actinin family.

13616:LOC100019389
gene id: 13616:LOC100019389
uniprot id: F6WYU4
names: Similarity
messages: Belongs to the globin family.

13616:B3GNT2
gene id: 13616:B3GNT2
uniprot id: F6YY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:SLC5A7
gene id: 13616:SLC5A7
uniprot id: F7DI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:STX6
gene id: 13616:STX6
uniprot id: F7EKN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

13616:MYCBP
gene id: 13616:MYCBP
uniprot id: A0A5F8GN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

13616:LOC103096762
gene id: 13616:LOC103096762
uniprot id: F7FKV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

13616:SEMA6A
gene id: 13616:SEMA6A
uniprot id: A0A5F8GI43
uniprot id: A0A5F8H6Z1
uniprot id: F6RM83
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VN2R528
gene id: 13616:VN2R528
uniprot id: F6Z9G8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CEP57
gene id: 13616:CEP57
uniprot id: A0A5F8H3Z7
names: Similarity
messages: Belongs to the translokin family.

13616:SPEN
gene id: 13616:SPEN
uniprot id: A0A5F8G4M9
uniprot id: A0A5F8GNF5
uniprot id: A0A5F8HDC4
uniprot id: F6VQG1
names: Similarity
messages: Belongs to the RRM Spen family.

13616:SLC7A6OS
gene id: 13616:SLC7A6OS
uniprot id: F6YQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

13616:IL10
gene id: 13616:IL10
uniprot id: F6UHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

13616:LOC100013238
gene id: 13616:LOC100013238
uniprot id: F6S9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:EBAG9
gene id: 13616:EBAG9
uniprot id: F6VMB3
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

13616:VN2R623
gene id: 13616:VN2R623
uniprot id: A0A5F8HK40
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ACAA1
gene id: 13616:ACAA1
uniprot id: F6XXA9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

13616:CLTA
gene id: 13616:CLTA
uniprot id: A0A5F8GSR6
uniprot id: A0A5F8HAV6
uniprot id: F7G4M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

13616:PLLP
gene id: 13616:PLLP
uniprot id: F7DRN4
names: Subcellular Location Annotation
messages: Membrane

13616:ANXA9
gene id: 13616:ANXA9
uniprot id: F6YYM0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:SLITRK3
gene id: 13616:SLITRK3
uniprot id: F7BHD9
names: Similarity
messages: Belongs to the SLITRK family.

13616:MAOA
gene id: 13616:MAOA
uniprot id: A0A5F8GC14
uniprot id: F6UIG4
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

13616:FAM199X
gene id: 13616:FAM199X
uniprot id: F6W884
names: Similarity
messages: Belongs to the FAM199 family.

13616:SLC25A32
gene id: 13616:SLC25A32
uniprot id: F7F3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:ZDHHC16
gene id: 13616:ZDHHC16
uniprot id: A0A5F8G6H2
uniprot id: F6QNX2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:PDGFD
gene id: 13616:PDGFD
uniprot id: F7F7V7
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RPL4
gene id: 13616:RPL4
uniprot id: F6QS92
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

13616:TLCD1
gene id: 13616:TLCD1
uniprot id: F6RZ31
names: Subcellular Location Annotation
messages: Membrane

13616:SEC61B
gene id: 13616:SEC61B
uniprot id: F6VXR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

13616:CERCAM
gene id: 13616:CERCAM
uniprot id: F6SKY7
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

13616:NUBPL
gene id: 13616:NUBPL
uniprot id: F6Y1Q6
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

13616:LOC100011028
gene id: 13616:LOC100011028
uniprot id: A0A5F8HF36
names: Subcellular Location Annotation
messages: Membrane

13616:ZNF408
gene id: 13616:ZNF408
uniprot id: F6W5U6
names: Subcellular Location Annotation
messages: Nucleus

13616:ACTBL2
gene id: 13616:ACTBL2
uniprot id: F6ZZG9
names: Similarity
messages: Belongs to the actin family.

13616:PYROXD1
gene id: 13616:PYROXD1
uniprot id: F6ZXZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

13616:MFSD10
gene id: 13616:MFSD10
uniprot id: F7DUZ0
names: Subcellular Location Annotation
messages: Membrane

13616:SLC46A1
gene id: 13616:SLC46A1
uniprot id: F6QTF6
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100030231
gene id: 13616:LOC100030231
uniprot id: F6W5P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NME4
gene id: 13616:NME4
uniprot id: A0A5F8H1F6
names: Similarity
messages: Belongs to the NDK family.

13616:PRMT5
gene id: 13616:PRMT5
uniprot id: F7A260
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

13616:SEMA4B
gene id: 13616:SEMA4B
uniprot id: F6VD85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100022501
gene id: 13616:LOC100022501
uniprot id: F6RT32
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Membrane
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

13616:FAM53C
gene id: 13616:FAM53C
uniprot id: A0A5F8H9N6
names: Similarity
messages: Belongs to the FAM53 family.

13616:DUSP27
gene id: 13616:DUSP27
uniprot id: F7B956
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

13616:PIR
gene id: 13616:PIR
uniprot id: F6WHS7
names: Similarity
messages: Belongs to the pirin family.

13616:VKORC1L1
gene id: 13616:VKORC1L1
uniprot id: F7E466
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC103094087
gene id: 13616:LOC103094087
uniprot id: A0A5F8GN60
uniprot id: F6ZJL2
names: Similarity
messages: Belongs to the Speedy/Ringo family.

13616:LOC100013602
gene id: 13616:LOC100013602
uniprot id: F7D2Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:FAM83B
gene id: 13616:FAM83B
uniprot id: A0A5F8G730
names: Similarity
messages: Belongs to the FAM83 family.

13616:LOC100013589
gene id: 13616:LOC100013589
uniprot id: F7EEM6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:TMC5
gene id: 13616:TMC5
uniprot id: F6RPV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

13616:SLC6A19
gene id: 13616:SLC6A19
uniprot id: F7A6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:DNAAF1
gene id: 13616:DNAAF1
uniprot id: F7ATT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: cilium

13616:PPM1B
gene id: 13616:PPM1B
uniprot id: F6WMG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

13616:ZC3H14
gene id: 13616:ZC3H14
uniprot id: A0A5F8GUT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

13616:SNTB1
gene id: 13616:SNTB1
uniprot id: F7CVW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

13616:LRP10
gene id: 13616:LRP10
uniprot id: F6ZCI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PRDM4
gene id: 13616:PRDM4
uniprot id: F7BBW4
names: Subcellular Location Annotation
messages: Nucleus

13616:CC2D1B
gene id: 13616:CC2D1B
uniprot id: F6W5J6
names: Similarity
messages: Belongs to the CC2D1 family.

13616:PDK3
gene id: 13616:PDK3
uniprot id: F7EDV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

13616:SLC27A2
gene id: 13616:SLC27A2
uniprot id: F6YDA1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:GOLT1B
gene id: 13616:GOLT1B
uniprot id: A0A5F8GGP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

13616:SLC35B3
gene id: 13616:SLC35B3
uniprot id: A0A5F8GZN9
uniprot id: F6TTM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

13616:AFF1
gene id: 13616:AFF1
uniprot id: F7G971
names: Similarity
messages: Belongs to the AF4 family.

13616:FGF14
gene id: 13616:FGF14
uniprot id: A0A5F8HBK8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:LOC100020945
gene id: 13616:LOC100020945
uniprot id: F6TES4
names: Similarity
messages: Belongs to the SNF7 family.

13616:SEC62
gene id: 13616:SEC62
uniprot id: F7CA52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:UBE2A
gene id: 13616:UBE2A
uniprot id: F6SAT6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:MRPS21
gene id: 13616:MRPS21
uniprot id: F7AD79
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

13616:SEC24D
gene id: 13616:SEC24D
uniprot id: F7G0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

13616:LOC100022336
gene id: 13616:LOC100022336
uniprot id: F7GF25
names: Similarity
messages: Belongs to the GroES chaperonin family.

13616:GRB10
gene id: 13616:GRB10
uniprot id: F6YZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

13616:TMEM254
gene id: 13616:TMEM254
uniprot id: F7D4D9
names: Subcellular Location Annotation
messages: Membrane

13616:LDB3
gene id: 13616:LDB3
uniprot id: A0A5F8GDP9
uniprot id: F6ZAK9
names: Subcellular Location Annotation
messages: Z line

13616:ABCG4
gene id: 13616:ABCG4
uniprot id: F7D9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

13616:CDNF
gene id: 13616:CDNF
uniprot id: A0A5F8GGW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

13616:ZNF488
gene id: 13616:ZNF488
uniprot id: F6WMS6
names: Subcellular Location Annotation
messages: Nucleus

13616:CASK
gene id: 13616:CASK
uniprot id: A0A5F8GLR6
uniprot id: A0A5F8GN34
names: Similarity
messages: Belongs to the MAGUK family.

13616:GALK2
gene id: 13616:GALK2
uniprot id: F7EGU0
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

13616:CATSPERD
gene id: 13616:CATSPERD
uniprot id: F6XVR8
names: Similarity
messages: Belongs to the CATSPERD family.

13616:NPRL2
gene id: 13616:NPRL2
uniprot id: F7G4N3
names: Similarity
messages: Belongs to the NPR2 family.

13616:CLDN7
gene id: 13616:CLDN7
uniprot id: F6ZWR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:MRPL9
gene id: 13616:MRPL9
uniprot id: F7CQD1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

13616:GPR3
gene id: 13616:GPR3
uniprot id: A0A5F8GDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:POLG2
gene id: 13616:POLG2
uniprot id: F7FAA1
names: Subcellular Location Annotation
messages: Mitochondrion

13616:MDH1
gene id: 13616:MDH1
uniprot id: F6PLH7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

13616:METTL15
gene id: 13616:METTL15
uniprot id: F7FNK2
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

13616:C2H1orf27
gene id: 13616:C2H1orf27
uniprot id: F6YEE1
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

13616:CLN3
gene id: 13616:CLN3
uniprot id: F6Z665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

13616:PSMC5
gene id: 13616:PSMC5
uniprot id: F6VUJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

13616:NCOA2
gene id: 13616:NCOA2
uniprot id: A0A5F8GWH9
uniprot id: F6ZNG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

13616:LOC100009811
gene id: 13616:LOC100009811
uniprot id: A0A5F8HI45
names: Similarity
messages: Belongs to the CLCR family.

13616:SLC7A3
gene id: 13616:SLC7A3
uniprot id: F7ASW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

13616:LOC100012932
gene id: 13616:LOC100012932
uniprot id: F6VWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IL4R
gene id: 13616:IL4R
uniprot id: K7E6C0
names: Subcellular Location Annotation
messages: Membrane

13616:YIPF2
gene id: 13616:YIPF2
uniprot id: F6XWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

13616:TMED6
gene id: 13616:TMED6
uniprot id: F6YGQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100014136
gene id: 13616:LOC100014136
uniprot id: A0A5F8GYJ8
uniprot id: A0A5F8H6G7
uniprot id: F7BW30
names: Similarity
messages: Belongs to the FAM122 family.

13616:ATXN7L3
gene id: 13616:ATXN7L3
uniprot id: F7DF88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

13616:GUCY2C
gene id: 13616:GUCY2C
uniprot id: F7B751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

13616:YAE1D1
gene id: 13616:YAE1D1
uniprot id: A0A5F8HI68
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:LOC100022683
gene id: 13616:LOC100022683
uniprot id: F6ZCG0
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

13616:CTPS1
gene id: 13616:CTPS1
uniprot id: F6WFF7
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

13616:CSTF3
gene id: 13616:CSTF3
uniprot id: F6X9G6
names: Subcellular Location Annotation
messages: Nucleus

13616:UGGT2
gene id: 13616:UGGT2
uniprot id: F7CUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

13616:ASIP
gene id: 13616:ASIP
uniprot id: F6YH41
names: Subcellular Location Annotation
messages: Secreted

13616:KLC4
gene id: 13616:KLC4
uniprot id: F7FP03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

13616:TFEC
gene id: 13616:TFEC
uniprot id: F7DUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

13616:TEX10
gene id: 13616:TEX10
uniprot id: F6S2L8
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

13616:PIGB
gene id: 13616:PIGB
uniprot id: F7D579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

13616:PLD4
gene id: 13616:PLD4
uniprot id: F6TEV9
names: Similarity
messages: Belongs to the phospholipase D family.

13616:NTS
gene id: 13616:NTS
uniprot id: A0A5F8HD06
uniprot id: F7F526
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

13616:DPYSL3
gene id: 13616:DPYSL3
uniprot id: A0A5F8GT34
uniprot id: F6URW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
messages: growth cone

13616:TPD52
gene id: 13616:TPD52
uniprot id: A0A5F8G4J0
uniprot id: A0A5F8GMK6
uniprot id: A0A5F8HDP1
uniprot id: F7GEU5
names: Similarity
messages: Belongs to the TPD52 family.

13616:ITGB5
gene id: 13616:ITGB5
uniprot id: F6PPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

13616:DAPK2
gene id: 13616:DAPK2
uniprot id: A0A5F8HHC4
uniprot id: F7CSM8
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:VN2R645
gene id: 13616:VN2R645
uniprot id: F7BFX0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ELF3
gene id: 13616:ELF3
uniprot id: F6XM40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:LOC100024828
gene id: 13616:LOC100024828
uniprot id: A0A5F8G8B7
names: Similarity
messages: Belongs to the apolipoprotein L family.

13616:CLGN
gene id: 13616:CLGN
uniprot id: F6XSA8
names: Similarity
messages: Belongs to the calreticulin family.

13616:SLC25A19
gene id: 13616:SLC25A19
uniprot id: F7EF03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:GNG5
gene id: 13616:GNG5
uniprot id: A0A5F8GVM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:GPATCH2
gene id: 13616:GPATCH2
uniprot id: A0A5F8GLY7
names: Similarity
messages: Belongs to the BicD family.

13616:DNAJC18
gene id: 13616:DNAJC18
uniprot id: F7CB96
names: Subcellular Location Annotation
messages: Membrane

13616:SPDEF
gene id: 13616:SPDEF
uniprot id: F6SVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:RORA
gene id: 13616:RORA
uniprot id: F6QXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:LOC100027035
gene id: 13616:LOC100027035
uniprot id: F6PJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RPL38
gene id: 13616:RPL38
uniprot id: F7FFK1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

13616:TNFRSF19
gene id: 13616:TNFRSF19
uniprot id: A0A5F8GYZ9
uniprot id: F7AL23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SRC
gene id: 13616:SRC
uniprot id: A0A5F8GEV3
uniprot id: A0A5F8GUX0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:LOC100013728
gene id: 13616:LOC100013728
uniprot id: A0A5F8H486
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ALG2
gene id: 13616:ALG2
uniprot id: A0A5F8H4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

13616:NADK2
gene id: 13616:NADK2
uniprot id: A0A5F8GBQ7
uniprot id: F7FK96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

13616:FTSJ3
gene id: 13616:FTSJ3
uniprot id: F6UUX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

13616:KCNQ2
gene id: 13616:KCNQ2
uniprot id: F6WQP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC103093927
gene id: 13616:LOC103093927
uniprot id: A0A5F8HKH0
names: Similarity
messages: Belongs to the cystatin family.

13616:BANF1
gene id: 13616:BANF1
uniprot id: F7GCP3
names: Subcellular Location Annotation
messages: Nucleus

13616:CNNM1
gene id: 13616:CNNM1
uniprot id: A0A5F8HAK4
uniprot id: F7G0P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

13616:LYPLA2
gene id: 13616:LYPLA2
uniprot id: F6ZPC7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

13616:ISCU
gene id: 13616:ISCU
uniprot id: A0A5F8G6L9
uniprot id: F6UVD9
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

13616:TSHR
gene id: 13616:TSHR
uniprot id: F7AAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

13616:LOC100024463
gene id: 13616:LOC100024463
uniprot id: A0A5F8HBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PDIA3
gene id: 13616:PDIA3
uniprot id: F7E4L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

13616:ST8SIA2
gene id: 13616:ST8SIA2
uniprot id: F6ZL24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:TPP1
gene id: 13616:TPP1
uniprot id: F7FRR4
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

13616:CC2D1A
gene id: 13616:CC2D1A
uniprot id: F7CV27
names: Similarity
messages: Belongs to the CC2D1 family.

13616:GADD45G
gene id: 13616:GADD45G
uniprot id: F7G7J2
names: Similarity
messages: Belongs to the GADD45 family.

13616:ALDH1A3
gene id: 13616:ALDH1A3
uniprot id: F7DI08
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

13616:SPARC
gene id: 13616:SPARC
uniprot id: A0A5F8HE45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

13616:LOC100015831
gene id: 13616:LOC100015831
uniprot id: A0A5F8HAI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:AKAP4
gene id: 13616:AKAP4
uniprot id: F6PK57
names: Similarity
messages: Belongs to the AKAP110 family.

13616:SLURP1
gene id: 13616:SLURP1
uniprot id: A0A5F8GZR6
names: Subcellular Location Annotation
messages: Membrane

13616:NCEH1
gene id: 13616:NCEH1
uniprot id: A0A5F8G3H2
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:EMSY
gene id: 13616:EMSY
uniprot id: A0A5F8GFH5
uniprot id: A0A5F8GY23
uniprot id: A0A5F8H3J3
uniprot id: A0A5F8HI90
uniprot id: F7DM87
names: Subcellular Location Annotation
messages: Nucleus

13616:MFSD8
gene id: 13616:MFSD8
uniprot id: F6YG84
names: Subcellular Location Annotation
messages: Membrane

13616:TEC
gene id: 13616:TEC
uniprot id: F7EN79
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:TMED10
gene id: 13616:TMED10
uniprot id: F6WFY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:FAM172A
gene id: 13616:FAM172A
uniprot id: A0A5F8GGE2
uniprot id: A0A5F8H6J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

13616:NSFL1C
gene id: 13616:NSFL1C
uniprot id: A0A5F8GFM0
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

13616:ATP8A1
gene id: 13616:ATP8A1
uniprot id: A0A5F8G638
uniprot id: A0A5F8G7E0
uniprot id: A0A5F8GPA3
uniprot id: F7A161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:PIK3C3
gene id: 13616:PIK3C3
uniprot id: A0A5F8GF03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

13616:MCL1
gene id: 13616:MCL1
uniprot id: F6ZMX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: nucleoplasm

13616:LOC103095046
gene id: 13616:LOC103095046
uniprot id: F7CK00
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

13616:ALDH18A1
gene id: 13616:ALDH18A1
uniprot id: F7F6P3
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

13616:KIF7
gene id: 13616:KIF7
uniprot id: F6UTW0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:RPL3L
gene id: 13616:RPL3L
uniprot id: F7EB35
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

13616:ACTG1
gene id: 13616:ACTG1
uniprot id: A0A5F8GD69
names: Similarity
messages: Belongs to the actin family.

13616:LOC100026196
gene id: 13616:LOC100026196
uniprot id: F6YF10
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:VEGFC
gene id: 13616:VEGFC
uniprot id: F6ZK49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

13616:CHMP1A
gene id: 13616:CHMP1A
uniprot id: A0A5F8GJP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

13616:IFRD2
gene id: 13616:IFRD2
uniprot id: A0A5F8G5Z6
uniprot id: F7CY73
names: Similarity
messages: Belongs to the IFRD family.

13616:RALB
gene id: 13616:RALB
uniprot id: F6WB97
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

13616:EXOSC2
gene id: 13616:EXOSC2
uniprot id: F7FU90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

13616:HAL
gene id: 13616:HAL
uniprot id: F7CKM9
names: Similarity
messages: Belongs to the PAL/histidase family.

13616:GBGT1
gene id: 13616:GBGT1
uniprot id: F6VXM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

13616:DPM1
gene id: 13616:DPM1
uniprot id: F6XRX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

13616:RPS6KA5
gene id: 13616:RPS6KA5
uniprot id: F7FUC1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

13616:LOC100030512
gene id: 13616:LOC100030512
uniprot id: F7FFU1
names: Subcellular Location Annotation
messages: Membrane

13616:LOC103094341
gene id: 13616:LOC103094341
uniprot id: K7E123
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:RBPJL
gene id: 13616:RBPJL
uniprot id: F7FYG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

13616:SLC25A35
gene id: 13616:SLC25A35
uniprot id: F7E9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:B4GALT1
gene id: 13616:B4GALT1
uniprot id: F7C2S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:DSCR3
gene id: 13616:DSCR3
uniprot id: F6S556
names: Similarity
messages: Belongs to the VPS26 family.

13616:WBP4
gene id: 13616:WBP4
uniprot id: F7GGY7
names: Subcellular Location Annotation
messages: Nucleus

13616:ATP5G3
gene id: 13616:ATP5G3
uniprot id: F7EV18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

13616:PKN3
gene id: 13616:PKN3
uniprot id: F6TSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

13616:RBM22
gene id: 13616:RBM22
uniprot id: F7AX36
names: Similarity
messages: Belongs to the SLT11 family.

13616:CNIH1
gene id: 13616:CNIH1
uniprot id: A0A5F8G1Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

13616:B4GALT3
gene id: 13616:B4GALT3
uniprot id: F6ZCN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:CLCN7
gene id: 13616:CLCN7
uniprot id: A0A5F8GJW9
uniprot id: F6PY30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

13616:MAGI3
gene id: 13616:MAGI3
uniprot id: F7AV49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

13616:TECRL
gene id: 13616:TECRL
uniprot id: F7ANT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

13616:LOC100028608
gene id: 13616:LOC100028608
uniprot id: F6SAU5
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:RRM2B
gene id: 13616:RRM2B
uniprot id: F6SL91
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

13616:ALDH7A1
gene id: 13616:ALDH7A1
uniprot id: F7E9M6
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

13616:DDR2
gene id: 13616:DDR2
uniprot id: A0A5F8H9N5
uniprot id: F7D3Z8
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100012514
gene id: 13616:LOC100012514
uniprot id: F6SSU7
names: Similarity
messages: Belongs to the peptidase M10A family.

13616:VN2R619
gene id: 13616:VN2R619
uniprot id: A0A5F8H0K8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SNAP47
gene id: 13616:SNAP47
uniprot id: F6X6M3
names: Similarity
messages: Belongs to the SVAP1 family.

13616:BAX
gene id: 13616:BAX
uniprot id: F6XQQ4
names: Similarity
messages: Belongs to the Bcl-2 family.

13616:PSMB7
gene id: 13616:PSMB7
uniprot id: F6WNU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

13616:SLC35F1
gene id: 13616:SLC35F1
uniprot id: A0A5F8HEL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

13616:TMCC2
gene id: 13616:TMCC2
uniprot id: A0A5F8HF74
uniprot id: F6WZC2
names: Similarity
messages: Belongs to the TEX28 family.

13616:LOC100032945
gene id: 13616:LOC100032945
uniprot id: F7DU33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

13616:IGFBP1
gene id: 13616:IGFBP1
uniprot id: F6XGI9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:LIN54
gene id: 13616:LIN54
uniprot id: F6YAP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

13616:ERG
gene id: 13616:ERG
uniprot id: A0A5F8GRC5
uniprot id: F6S580
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:GPC1
gene id: 13616:GPC1
uniprot id: F7FML1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

13616:LOC100016601
gene id: 13616:LOC100016601
uniprot id: F7EU36
names: Similarity
messages: Belongs to the actin family.

13616:MRPL50
gene id: 13616:MRPL50
uniprot id: F6RH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

13616:SMIM8
gene id: 13616:SMIM8
uniprot id: A0A5F8GLN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

13616:PIGF
gene id: 13616:PIGF
uniprot id: A0A5F8HD39
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:KDSR
gene id: 13616:KDSR
uniprot id: F7GGW4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:SLC35E3
gene id: 13616:SLC35E3
uniprot id: F6WCA6
names: Subcellular Location Annotation
messages: Membrane

13616:CUL3
gene id: 13616:CUL3
uniprot id: F6UH62
names: Similarity
messages: Belongs to the cullin family.

13616:SNX4
gene id: 13616:SNX4
uniprot id: A0A5F8H5M8
uniprot id: F6QVT1
names: Similarity
messages: Belongs to the sorting nexin family.

13616:MAPKAPK3
gene id: 13616:MAPKAPK3
uniprot id: F7CUT8
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:CEP57L1
gene id: 13616:CEP57L1
uniprot id: A0A5F8GND6
uniprot id: A0A5F8HFG1
names: Similarity
messages: Belongs to the translokin family.

13616:P4HA2
gene id: 13616:P4HA2
uniprot id: A0A5F8GN51
uniprot id: F6UQK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

13616:ISY1
gene id: 13616:ISY1
uniprot id: F7CDJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

13616:EIF3E
gene id: 13616:EIF3E
uniprot id: F6ZC02
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

13616:TGM2
gene id: 13616:TGM2
uniprot id: F6TFD4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

13616:CHD7
gene id: 13616:CHD7
uniprot id: F7G444
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

13616:HPDL
gene id: 13616:HPDL
uniprot id: F7A0G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

13616:LOC100013050
gene id: 13616:LOC100013050
uniprot id: A0A5F8GT56
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:LOC100013114
gene id: 13616:LOC100013114
uniprot id: F6VTP9
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:CPA3
gene id: 13616:CPA3
uniprot id: F6TIS2
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:EDEM2
gene id: 13616:EDEM2
uniprot id: A0A5F8HKP9
uniprot id: F6SNH2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

13616:LOC100029982
gene id: 13616:LOC100029982
uniprot id: F6SLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100031129
gene id: 13616:LOC100031129
uniprot id: A0A5F8H461
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:CHAC2
gene id: 13616:CHAC2
uniprot id: A0A5F8G8Z6
uniprot id: F7BBA1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

13616:PTCD3
gene id: 13616:PTCD3
uniprot id: F7CQ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

13616:NKX6-1
gene id: 13616:NKX6-1
uniprot id: F6Z980
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100031667
gene id: 13616:LOC100031667
uniprot id: F7GGE6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:PFAS
gene id: 13616:PFAS
uniprot id: A0A5F8H032
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

13616:IMMT
gene id: 13616:IMMT
uniprot id: F6RDZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

13616:HADH
gene id: 13616:HADH
uniprot id: F6ZBI7
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

13616:KRT4
gene id: 13616:KRT4
uniprot id: F6PSM3
names: Similarity
messages: Belongs to the intermediate filament family.

13616:CDX2
gene id: 13616:CDX2
uniprot id: F7B348
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

13616:SLC2A8
gene id: 13616:SLC2A8
uniprot id: F6SU86
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:ATP9A
gene id: 13616:ATP9A
uniprot id: F7EQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:RAE1
gene id: 13616:RAE1
uniprot id: F7A424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: spindle pole

13616:QRFPR
gene id: 13616:QRFPR
uniprot id: F7GB29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:WNT16
gene id: 13616:WNT16
uniprot id: F6WWA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:UBE2L3
gene id: 13616:UBE2L3
uniprot id: A0A5F8GNU3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:CDCA2
gene id: 13616:CDCA2
uniprot id: F7D1W5
names: Subcellular Location Annotation
messages: Nucleus

13616:HTR1E
gene id: 13616:HTR1E
uniprot id: F6XI83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMX2
gene id: 13616:TMX2
uniprot id: F7EA08
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

13616:RAD51
gene id: 13616:RAD51
uniprot id: F6WB93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

13616:POU4F2
gene id: 13616:POU4F2
uniprot id: F6X542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

13616:FOXN1
gene id: 13616:FOXN1
uniprot id: F6QSP6
names: Subcellular Location Annotation
messages: Nucleus

13616:GPHB5
gene id: 13616:GPHB5
uniprot id: F7GCN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

13616:TUSC5
gene id: 13616:TUSC5
uniprot id: F6Y8J9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:HMX3
gene id: 13616:HMX3
uniprot id: F7G0H2
names: Subcellular Location Annotation
messages: Nucleus

13616:FAM19A4
gene id: 13616:FAM19A4
uniprot id: K7DZQ7
names: Similarity
messages: Belongs to the TAFA family.

13616:YIPF7
gene id: 13616:YIPF7
uniprot id: F7A0P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

13616:PAQR9
gene id: 13616:PAQR9
uniprot id: F7DX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:LOC103096413
gene id: 13616:LOC103096413
uniprot id: F6YQE3
names: Subcellular Location Annotation
messages: Secreted

13616:T2R39
gene id: 13616:T2R39
uniprot id: Q2AB88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:WASF3
gene id: 13616:WASF3
uniprot id: A0A5F8H125
uniprot id: F6QUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

13616:DR1
gene id: 13616:DR1
uniprot id: F6UL95
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

13616:LOC100022003
gene id: 13616:LOC100022003
uniprot id: A0A5F8GG13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LAMP3
gene id: 13616:LAMP3
uniprot id: A0A5F8H8Y0
uniprot id: F7GE18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

13616:SV2C
gene id: 13616:SV2C
uniprot id: F6PIT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

13616:LOC100030359
gene id: 13616:LOC100030359
uniprot id: F7CH89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

13616:RNF43
gene id: 13616:RNF43
uniprot id: F7D310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

13616:HOMER2
gene id: 13616:HOMER2
uniprot id: F6WSQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

13616:GREB1L
gene id: 13616:GREB1L
uniprot id: F7GK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

13616:ALG14
gene id: 13616:ALG14
uniprot id: F6SY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

13616:AFM
gene id: 13616:AFM
uniprot id: F7AX94
names: Subcellular Location Annotation
messages: Secreted

13616:CD8A
gene id: 13616:CD8A
uniprot id: I6LJ10
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:GPRC5C
gene id: 13616:GPRC5C
uniprot id: A0A5F8HDM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100028609
gene id: 13616:LOC100028609
uniprot id: F7ET81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100019374
gene id: 13616:LOC100019374
uniprot id: F6Z4P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KCNE1
gene id: 13616:KCNE1
uniprot id: F7E651
names: Similarity
messages: Belongs to the potassium channel KCNE family.

13616:ANAPC5
gene id: 13616:ANAPC5
uniprot id: F7ALY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

13616:LOC103098396
gene id: 13616:LOC103098396
uniprot id: F6PJE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:WNT5B
gene id: 13616:WNT5B
uniprot id: A0A5F8GU38
uniprot id: A0A5F8HJT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:KCNH6
gene id: 13616:KCNH6
uniprot id: F6ZE77
names: Subcellular Location Annotation
messages: Membrane

13616:XYLT1
gene id: 13616:XYLT1
uniprot id: F6XD49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

13616:CTBP2
gene id: 13616:CTBP2
uniprot id: A0A5F8G8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

13616:SLC16A14
gene id: 13616:SLC16A14
uniprot id: F6U0N6
names: Subcellular Location Annotation
messages: Membrane

13616:TRAK2
gene id: 13616:TRAK2
uniprot id: F7B9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

13616:SEC61A2
gene id: 13616:SEC61A2
uniprot id: F7FIG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:GHRH
gene id: 13616:GHRH
uniprot id: A0A5F8G7T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

13616:DPY19L3
gene id: 13616:DPY19L3
uniprot id: A0A5F8GCN3
uniprot id: F7DHQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

13616:LOC100026693
gene id: 13616:LOC100026693
uniprot id: F7FVE9
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

13616:LOC100018127
gene id: 13616:LOC100018127
uniprot id: A0A5F8G6W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:OIT3
gene id: 13616:OIT3
uniprot id: F6YCC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ATP6V0A2
gene id: 13616:ATP6V0A2
uniprot id: F6PM24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

13616:LOC100017912
gene id: 13616:LOC100017912
uniprot id: F6UHN1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:MOCS3
gene id: 13616:MOCS3
uniprot id: F6XRW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

13616:SNX25
gene id: 13616:SNX25
uniprot id: F6U6G2
names: Similarity
messages: Belongs to the sorting nexin family.

13616:LOC100020689
gene id: 13616:LOC100020689
uniprot id: F6S985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100018646
gene id: 13616:LOC100018646
uniprot id: F6W7S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:STEAP3
gene id: 13616:STEAP3
uniprot id: F6QMH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

13616:TMEM168
gene id: 13616:TMEM168
uniprot id: F7AGF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

13616:UNC5C
gene id: 13616:UNC5C
uniprot id: F6Q8P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

13616:CUL4A
gene id: 13616:CUL4A
uniprot id: F7G925
names: Similarity
messages: Belongs to the cullin family.

13616:KCNA5
gene id: 13616:KCNA5
uniprot id: F7EBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

13616:ERMN
gene id: 13616:ERMN
uniprot id: A0A5F8HDM9
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

13616:LOC100026649
gene id: 13616:LOC100026649
uniprot id: F7D0I5
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

13616:ART3
gene id: 13616:ART3
uniprot id: F6RZQ4
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

13616:PCYOX1L
gene id: 13616:PCYOX1L
uniprot id: F6XEG6
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

13616:LOC100010102
gene id: 13616:LOC100010102
uniprot id: F7EIN0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:PLG
gene id: 13616:PLG
uniprot id: F7F243
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

13616:ACBD5
gene id: 13616:ACBD5
uniprot id: A0A5F8H489
uniprot id: F7GEL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

13616:PARK7
gene id: 13616:PARK7
uniprot id: A0A5F8HEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

13616:NQO1
gene id: 13616:NQO1
uniprot id: F7CXV7
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

13616:CYP27A1
gene id: 13616:CYP27A1
uniprot id: F6WH61
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:ZCCHC11
gene id: 13616:ZCCHC11
uniprot id: A0A5F8G275
uniprot id: A0A5F8GMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

13616:ABAT
gene id: 13616:ABAT
uniprot id: F6XY07
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

13616:ERCC3
gene id: 13616:ERCC3
uniprot id: F7FQP6
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

13616:NDEL1
gene id: 13616:NDEL1
uniprot id: F7CL14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

13616:UTP6
gene id: 13616:UTP6
uniprot id: F6ZIB6
names: Similarity
messages: Belongs to the UTP6 family.

13616:LOC100013915
gene id: 13616:LOC100013915
uniprot id: A0A5F8HDP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:SRP9
gene id: 13616:SRP9
uniprot id: A0A5F8G7U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

13616:TCP11
gene id: 13616:TCP11
uniprot id: F6X6Q9
names: Similarity
messages: Belongs to the TCP11 family.

13616:KCNQ4
gene id: 13616:KCNQ4
uniprot id: F7B5A9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:GJB3
gene id: 13616:GJB3
uniprot id: F6TSG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:CD47
gene id: 13616:CD47
uniprot id: A0A5F8HJU7
uniprot id: F6ZW27
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:C4H19orf54
gene id: 13616:C4H19orf54
uniprot id: F6TXU5
names: Similarity
messages: Belongs to the UPF0692 family.

13616:ATP6V0E1
gene id: 13616:ATP6V0E1
uniprot id: A0A5F8H4M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:POLG
gene id: 13616:POLG
uniprot id: A0A5F8G911
names: Function
names: Subcellular Location Annotation
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

13616:GNB3
gene id: 13616:GNB3
uniprot id: F7CXD0
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

13616:LACTB2
gene id: 13616:LACTB2
uniprot id: F7FC68
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

13616:EPOR
gene id: 13616:EPOR
uniprot id: F7BUV5
names: Subcellular Location Annotation
messages: Membrane

13616:HOXD3
gene id: 13616:HOXD3
uniprot id: A0A5F8GV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:TNFRSF21
gene id: 13616:TNFRSF21
uniprot id: F6Z1T7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SLC33A1
gene id: 13616:SLC33A1
uniprot id: F6Z4G4
names: Subcellular Location Annotation
messages: Membrane

13616:RPS4Y1
gene id: 13616:RPS4Y1
uniprot id: O62739
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

13616:FAM160A1
gene id: 13616:FAM160A1
uniprot id: A0A5F8GPI5
uniprot id: F6ZFD7
names: Similarity
messages: Belongs to the FHIP family.

13616:NR1I3
gene id: 13616:NR1I3
uniprot id: F7A3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:MPI
gene id: 13616:MPI
uniprot id: A0A5F8G5T3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

13616:GIPC1
gene id: 13616:GIPC1
uniprot id: F7ALU7
names: Similarity
messages: Belongs to the GIPC family.

13616:ETV4
gene id: 13616:ETV4
uniprot id: F7BW11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:HYOU1
gene id: 13616:HYOU1
uniprot id: F7GJH2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:KCNC1
gene id: 13616:KCNC1
uniprot id: F7CX06
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100015440
gene id: 13616:LOC100015440
uniprot id: F6R624
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

13616:KCNA2
gene id: 13616:KCNA2
uniprot id: F6UCV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

13616:KCNS2
gene id: 13616:KCNS2
uniprot id: F7E3Z0
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100010818
gene id: 13616:LOC100010818
uniprot id: A0A5F8G520
uniprot id: A0A5F8G577
uniprot id: A0A5F8GJ50
uniprot id: A0A5F8H9B7
uniprot id: F6ZZC2
uniprot id: K7E3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

13616:MYF6
gene id: 13616:MYF6
uniprot id: A0A5F8GZT0
names: Subcellular Location Annotation
messages: Nucleus

13616:IER5L
gene id: 13616:IER5L
uniprot id: F7CX31
names: Similarity
messages: Belongs to the IER family.

13616:BEST3
gene id: 13616:BEST3
uniprot id: F7F684
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

13616:FEZ2
gene id: 13616:FEZ2
uniprot id: A0A5F8HGY6
uniprot id: F6TKQ2
names: Similarity
messages: Belongs to the zygin family.

13616:CFAP53
gene id: 13616:CFAP53
uniprot id: F7AAE6
names: Similarity
messages: Belongs to the CFAP53 family.

13616:PLCB2
gene id: 13616:PLCB2
uniprot id: F6Y4X0
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

13616:REV1
gene id: 13616:REV1
uniprot id: F7BD34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

13616:ACP7
gene id: 13616:ACP7
uniprot id: F7G9N0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

13616:LOC100022248
gene id: 13616:LOC100022248
uniprot id: F6Q020
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ARPC4
gene id: 13616:ARPC4
uniprot id: F7EQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

13616:SLX4
gene id: 13616:SLX4
uniprot id: F7AT45
names: Similarity
messages: Belongs to the SLX4 family.

13616:GALNT1
gene id: 13616:GALNT1
uniprot id: F6TU35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100023582
gene id: 13616:LOC100023582
uniprot id: A0A5F8GV83
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:YWHAQ
gene id: 13616:YWHAQ
uniprot id: F6ZC14
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:RUNX2
gene id: 13616:RUNX2
uniprot id: A0A5F8HEI7
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

13616:NKX2-5
gene id: 13616:NKX2-5
uniprot id: F7BSL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

13616:LOC100026919
gene id: 13616:LOC100026919
uniprot id: A0A5F8HJ35
names: Subcellular Location Annotation
messages: Membrane

13616:C5H11orf58
gene id: 13616:C5H11orf58
uniprot id: A0A5F8GUU7
names: Similarity
messages: Belongs to the SMAP family.

13616:EPC2
gene id: 13616:EPC2
uniprot id: A0A5F8GET6
uniprot id: A0A5F8GI32
uniprot id: F7DWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

13616:VPS37C
gene id: 13616:VPS37C
uniprot id: F7FWK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

13616:LOC100021261
gene id: 13616:LOC100021261
uniprot id: F6UGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

13616:PATL1
gene id: 13616:PATL1
uniprot id: F7G829
names: Similarity
messages: Belongs to the PAT1 family.

13616:LOC103105183
gene id: 13616:LOC103105183
uniprot id: A0A5F8GF70
names: Subcellular Location Annotation
messages: Nucleus

13616:B9D2
gene id: 13616:B9D2
uniprot id: F6PGL5
names: Subcellular Location Annotation
messages: cilium basal body

13616:HSF2
gene id: 13616:HSF2
uniprot id: A0A5F8HDN1
uniprot id: F7E523
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

13616:RGS3
gene id: 13616:RGS3
uniprot id: F6X2A9
names: Subcellular Location Annotation
messages: Cytoplasm

13616:ODF1
gene id: 13616:ODF1
uniprot id: F6XD73
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

13616:E2F8
gene id: 13616:E2F8
uniprot id: F7B2W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:ZNF330
gene id: 13616:ZNF330
uniprot id: F6SZ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

13616:PAIP2B
gene id: 13616:PAIP2B
uniprot id: F6ZAI5
names: Similarity
messages: Belongs to the PAIP2 family.

13616:DDOST
gene id: 13616:DDOST
uniprot id: F7FDG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

13616:FAM131A
gene id: 13616:FAM131A
uniprot id: F7DEE3
names: Similarity
messages: Belongs to the FAM131 family.

13616:GCDH
gene id: 13616:GCDH
uniprot id: F6V0X1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:SERPINB2
gene id: 13616:SERPINB2
uniprot id: F7CGR3
names: Similarity
messages: Belongs to the serpin family.

13616:RTN3
gene id: 13616:RTN3
uniprot id: A0A5F8HKC7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:MRI1
gene id: 13616:MRI1
uniprot id: F7G2V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

13616:ADD3
gene id: 13616:ADD3
uniprot id: A0A5F8HGX9
uniprot id: F7DP92
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

13616:CLDN1
gene id: 13616:CLDN1
uniprot id: A0A5F8GD39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:MAGT1
gene id: 13616:MAGT1
uniprot id: A0A5F8GR67
uniprot id: F7G9H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PLP1
gene id: 13616:PLP1
uniprot id: K7E0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

13616:CALHM1
gene id: 13616:CALHM1
uniprot id: F7F4B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:PYCR2
gene id: 13616:PYCR2
uniprot id: F6WFB0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

13616:EDNRA
gene id: 13616:EDNRA
uniprot id: F6STK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

13616:MAPK14
gene id: 13616:MAPK14
uniprot id: A0A5F8GJU8
uniprot id: F6YAB9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

13616:SLC25A4
gene id: 13616:SLC25A4
uniprot id: F6UNG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:GABRA4
gene id: 13616:GABRA4
uniprot id: F6ZBG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:MYH11
gene id: 13616:MYH11
uniprot id: A0A5F8GU50
uniprot id: A0A5F8HIJ3
uniprot id: F7FAW0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:POLR3D
gene id: 13616:POLR3D
uniprot id: F7FN65
names: Subcellular Location Annotation
messages: Nucleus

13616:NIPA1
gene id: 13616:NIPA1
uniprot id: F6X3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:POLR1C
gene id: 13616:POLR1C
uniprot id: F7G057
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

13616:LOC100028082
gene id: 13616:LOC100028082
uniprot id: A0A5F8H8R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100618832
gene id: 13616:LOC100618832
uniprot id: A0A5F8GBN6
names: Similarity
messages: Belongs to the intermediate filament family.

13616:ADRB3
gene id: 13616:ADRB3
uniprot id: F7CIS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.
messages: Membrane

13616:XRN2
gene id: 13616:XRN2
uniprot id: A0A5F8G1M1
uniprot id: A0A5F8H4P8
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

13616:LOC100027300
gene id: 13616:LOC100027300
uniprot id: F6V138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

13616:SCML4
gene id: 13616:SCML4
uniprot id: F7AKJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

13616:POLR2J
gene id: 13616:POLR2J
uniprot id: F6VE83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

13616:FAM188A
gene id: 13616:FAM188A
uniprot id: F6TUG9
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

13616:IP6K2
gene id: 13616:IP6K2
uniprot id: F6UYJ2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

13616:TNS3
gene id: 13616:TNS3
uniprot id: A0A5F8GXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

13616:C2H1orf52
gene id: 13616:C2H1orf52
uniprot id: F6WAF9
names: Similarity
messages: Belongs to the UPF0690 family.

13616:NAA38
gene id: 13616:NAA38
uniprot id: A0A5F8GTX9
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

13616:FAM136A
gene id: 13616:FAM136A
uniprot id: F6QXV8
names: Similarity
messages: Belongs to the FAM136 family.

13616:SFXN3
gene id: 13616:SFXN3
uniprot id: F7DZH8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

13616:LOC100019902
gene id: 13616:LOC100019902
uniprot id: F6SRP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GDPD4
gene id: 13616:GDPD4
uniprot id: A0A5F8GH73
uniprot id: A0A5F8GZA7
uniprot id: F6YMM7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

13616:SNCG
gene id: 13616:SNCG
uniprot id: A0A5F8HL03
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

13616:SRSF5
gene id: 13616:SRSF5
uniprot id: F6T5A0
names: Similarity
messages: Belongs to the splicing factor SR family.

13616:MTO1
gene id: 13616:MTO1
uniprot id: F7GD23
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

13616:CRELD2
gene id: 13616:CRELD2
uniprot id: F6Z426
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SERPINA10
gene id: 13616:SERPINA10
uniprot id: F7G300
names: Similarity
messages: Belongs to the serpin family.

13616:THEMIS
gene id: 13616:THEMIS
uniprot id: A0A5F8GUM9
uniprot id: F6YJA9
names: Similarity
messages: Belongs to the themis family.

13616:LOC100617777
gene id: 13616:LOC100617777
uniprot id: F7GC32
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle

13616:monDomV1R1274
gene id: 13616:monDomV1R1274
uniprot id: A0A5F8GQ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NTHL1
gene id: 13616:NTHL1
uniprot id: F6YUY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

13616:LOC100027820
gene id: 13616:LOC100027820
uniprot id: A0A5F8H4D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

13616:RPL22
gene id: 13616:RPL22
uniprot id: A0A5F8H0Y1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

13616:SLC5A10
gene id: 13616:SLC5A10
uniprot id: F7F7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:CDK5RAP1
gene id: 13616:CDK5RAP1
uniprot id: F6TGF1
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

13616:AASDH
gene id: 13616:AASDH
uniprot id: F7DKF4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:PPP1R15B
gene id: 13616:PPP1R15B
uniprot id: F7BX77
names: Similarity
messages: Belongs to the PPP1R15 family.

13616:LACE1
gene id: 13616:LACE1
uniprot id: A0A5F8GVS7
names: Similarity
messages: Belongs to the AFG1 ATPase family.

13616:ZGPAT
gene id: 13616:ZGPAT
uniprot id: F6QEZ5
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CHD4/Mi-2; the interaction is direct.
messages: Nucleus

13616:LOC100015779
gene id: 13616:LOC100015779
uniprot id: A0A5F8G1X2
uniprot id: F7BAV0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

13616:ERGIC2
gene id: 13616:ERGIC2
uniprot id: A0A5F8GQG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

13616:EXO1
gene id: 13616:EXO1
uniprot id: F6PWE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

13616:PABPC1L
gene id: 13616:PABPC1L
uniprot id: A0A5F8H1R1
uniprot id: F6TY24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

13616:CACTIN
gene id: 13616:CACTIN
uniprot id: F6PFY9
names: Similarity
messages: Belongs to the CACTIN family.

13616:PROZ
gene id: 13616:PROZ
uniprot id: A0A5F8GN67
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GLCE
gene id: 13616:GLCE
uniprot id: A0A5F8G9F3
uniprot id: A0A5F8GB43
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

13616:RNGTT
gene id: 13616:RNGTT
uniprot id: A0A5F8HKX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

13616:PFKFB1
gene id: 13616:PFKFB1
uniprot id: A0A5F8GVT7
uniprot id: F6SPM4
uniprot id: K7E1I7
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

13616:TLL1
gene id: 13616:TLL1
uniprot id: F7DZV7
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CHMP4B
gene id: 13616:CHMP4B
uniprot id: F7EIX3
names: Similarity
messages: Belongs to the SNF7 family.

13616:NDRG4
gene id: 13616:NDRG4
uniprot id: A0A5F8G927
uniprot id: F6U7Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

13616:LOC100020693
gene id: 13616:LOC100020693
uniprot id: F6VGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:PUS10
gene id: 13616:PUS10
uniprot id: F7G3Q0
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

13616:LOC103096620
gene id: 13616:LOC103096620
uniprot id: K7E1S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

13616:GALNT12
gene id: 13616:GALNT12
uniprot id: F6T058
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:SV2A
gene id: 13616:SV2A
uniprot id: F7DXP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

13616:LOC100030263
gene id: 13616:LOC100030263
uniprot id: F6SQ46
names: Similarity
messages: Belongs to the peptidase A1 family.

13616:AHCY
gene id: 13616:AHCY
uniprot id: F6Z693
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

13616:MTFR1L
gene id: 13616:MTFR1L
uniprot id: F6VAA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

13616:FBXO32
gene id: 13616:FBXO32
uniprot id: F6RIR8
names: Subcellular Location Annotation
messages: Nucleus

13616:CRYBB3
gene id: 13616:CRYBB3
uniprot id: F7AUT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

13616:TFPI
gene id: 13616:TFPI
uniprot id: F7C0N5
names: Subcellular Location Annotation
messages: Secreted

13616:PLD5
gene id: 13616:PLD5
uniprot id: F6PGF6
names: Similarity
messages: Belongs to the phospholipase D family.

13616:MPV17L2
gene id: 13616:MPV17L2
uniprot id: F6VFY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

13616:LOC103096099
gene id: 13616:LOC103096099
uniprot id: A0A5F8G7N1
uniprot id: A0A5F8G9B7
uniprot id: A0A5F8HDW3
names: Function
messages: Major early eggshell protein.

13616:LOC100023149
gene id: 13616:LOC100023149
uniprot id: F6YLC4
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:RFFL
gene id: 13616:RFFL
uniprot id: A0A5F8G6E5
uniprot id: F7EC98
names: Subcellular Location Annotation
messages: Cell membrane

13616:monDomV1R1201
gene id: 13616:monDomV1R1201
uniprot id: A0A5F8G3B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:QPCT
gene id: 13616:QPCT
uniprot id: F7F2N3
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

13616:MECP2
gene id: 13616:MECP2
uniprot id: F6TJ54
names: Subcellular Location Annotation
messages: Nucleus

13616:CUTA
gene id: 13616:CUTA
uniprot id: F6YZZ1
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

13616:PPAN
gene id: 13616:PPAN
uniprot id: F7EPT2
names: Subcellular Location Annotation
messages: nucleolus

13616:C4H2orf76
gene id: 13616:C4H2orf76
uniprot id: A0A5F8H671
names: Similarity
messages: Belongs to the UPF0538 family.

13616:LOC100619965
gene id: 13616:LOC100619965
uniprot id: A0A5F8H2K5
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

13616:IER2
gene id: 13616:IER2
uniprot id: F7A538
names: Similarity
messages: Belongs to the IER family.

13616:LOC103103068
gene id: 13616:LOC103103068
uniprot id: F7B859
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

13616:LOC100015520
gene id: 13616:LOC100015520
uniprot id: A0A5F8GB15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:MRPS26
gene id: 13616:MRPS26
uniprot id: F7FVQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

13616:HMGB1
gene id: 13616:HMGB1
uniprot id: F7EDR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Secreted

13616:PRDM12
gene id: 13616:PRDM12
uniprot id: F7FUD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

13616:MXRA8
gene id: 13616:MXRA8
uniprot id: F7FD57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:MRPL47
gene id: 13616:MRPL47
uniprot id: A0A5F8GC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

13616:ORC1
gene id: 13616:ORC1
uniprot id: F6QFY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus

13616:LOC100031017
gene id: 13616:LOC100031017
uniprot id: F6QJ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

13616:FAM214B
gene id: 13616:FAM214B
uniprot id: F7EUT4
names: Similarity
messages: Belongs to the FAM214 family.

13616:SUSD4
gene id: 13616:SUSD4
uniprot id: A0A5F8GP09
uniprot id: F7FLA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:FAM49B
gene id: 13616:FAM49B
uniprot id: A0A5F8G463
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

13616:ERAP1
gene id: 13616:ERAP1
uniprot id: F7GID7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:SNX3
gene id: 13616:SNX3
uniprot id: A0A5F8GWF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

13616:monDomV1R1241
gene id: 13616:monDomV1R1241
uniprot id: A0A5F8GDD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FOXF1
gene id: 13616:FOXF1
uniprot id: F6U913
names: Subcellular Location Annotation
messages: Nucleus

13616:RPF2
gene id: 13616:RPF2
uniprot id: A0A5F8H2N5
uniprot id: F7F2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

13616:ZCCHC17
gene id: 13616:ZCCHC17
uniprot id: A0A5F8HHQ1
names: Subcellular Location Annotation
messages: nucleolus

13616:FGFBP1
gene id: 13616:FGFBP1
uniprot id: F7DVS2
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

13616:ARHGEF38
gene id: 13616:ARHGEF38
uniprot id: F7F3Z6
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack

13616:IL15RA
gene id: 13616:IL15RA
uniprot id: A0A5F8HF25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GIF
gene id: 13616:GIF
uniprot id: F7FXU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

13616:LOC100022691
gene id: 13616:LOC100022691
uniprot id: F6RKE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ENPP4
gene id: 13616:ENPP4
uniprot id: F7C782
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

13616:MRPL35
gene id: 13616:MRPL35
uniprot id: F7CPF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

13616:LOC100617205
gene id: 13616:LOC100617205
uniprot id: A0A5F8G1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100030035
gene id: 13616:LOC100030035
uniprot id: A0A5F8GVB0
names: Subcellular Location Annotation
messages: Membrane

13616:SLC16A3
gene id: 13616:SLC16A3
uniprot id: F7GBJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

13616:LOC100024810
gene id: 13616:LOC100024810
uniprot id: F6VY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

13616:GRIA1
gene id: 13616:GRIA1
uniprot id: F7B4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:LOC100015032
gene id: 13616:LOC100015032
uniprot id: F6VP59
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:LTA4H
gene id: 13616:LTA4H
uniprot id: A0A5F8GN45
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

13616:YPEL3
gene id: 13616:YPEL3
uniprot id: F7EHP1
names: Similarity
messages: Belongs to the yippee family.

13616:ZIC3
gene id: 13616:ZIC3
uniprot id: F6V8L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

13616:RBL2
gene id: 13616:RBL2
uniprot id: F6ZM79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

13616:PPAT
gene id: 13616:PPAT
uniprot id: K7DZI9
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

13616:SHQ1
gene id: 13616:SHQ1
uniprot id: F7FH73
names: Similarity
messages: Belongs to the SHQ1 family.

13616:MEMO1
gene id: 13616:MEMO1
uniprot id: A0A5F8GE80
names: Similarity
messages: Belongs to the MEMO1 family.

13616:ASUN
gene id: 13616:ASUN
uniprot id: F6ZC79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100010487
gene id: 13616:LOC100010487
uniprot id: F6YEH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:SLC6A4
gene id: 13616:SLC6A4
uniprot id: F6VD16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

13616:PDE3B
gene id: 13616:PDE3B
uniprot id: F7FQK6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:CFI
gene id: 13616:CFI
uniprot id: A0A5F8HF52
uniprot id: F6R2B1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TRADD
gene id: 13616:TRADD
uniprot id: F7FRX7
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

13616:B3GNT4
gene id: 13616:B3GNT4
uniprot id: F7CXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LPAR6
gene id: 13616:LPAR6
uniprot id: F6ZZ79
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:RAD23B
gene id: 13616:RAD23B
uniprot id: F7ASD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

13616:MBOAT7
gene id: 13616:MBOAT7
uniprot id: F7D7G7
names: Subcellular Location Annotation
messages: Membrane

13616:GNA15
gene id: 13616:GNA15
uniprot id: F7EC94
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

13616:APMAP
gene id: 13616:APMAP
uniprot id: F7BQY7
names: Similarity
messages: Belongs to the strictosidine synthase family.

13616:CENPK
gene id: 13616:CENPK
uniprot id: A0A5F8H2W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

13616:KRT32
gene id: 13616:KRT32
uniprot id: F6SRI1
names: Similarity
messages: Belongs to the intermediate filament family.

13616:C3H19orf53
gene id: 13616:C3H19orf53
uniprot id: F7G2Q5
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

13616:TDRD7
gene id: 13616:TDRD7
uniprot id: F6PIW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

13616:LOC100024515
gene id: 13616:LOC100024515
uniprot id: F7F0L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TOR1AIP1
gene id: 13616:TOR1AIP1
uniprot id: F7FE19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

13616:IARS2
gene id: 13616:IARS2
uniprot id: F6VRQ6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:SLC26A2
gene id: 13616:SLC26A2
uniprot id: A0A5F8HCP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

13616:PKP2
gene id: 13616:PKP2
uniprot id: A0A5F8HBV7
uniprot id: F6S0Z1
names: Similarity
messages: Belongs to the beta-catenin family.

13616:MLLT11
gene id: 13616:MLLT11
uniprot id: F7CM88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

13616:POLR3F
gene id: 13616:POLR3F
uniprot id: F7CFH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

13616:HSD17B4
gene id: 13616:HSD17B4
uniprot id: F7CLZ9
names: Subcellular Location Annotation
messages: Peroxisome

13616:RNASEH2B
gene id: 13616:RNASEH2B
uniprot id: A0A5F8HKH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

13616:VN2R627
gene id: 13616:VN2R627
uniprot id: F6WGS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SEPHS1
gene id: 13616:SEPHS1
uniprot id: F6Y2T3
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

13616:LOC100021710
gene id: 13616:LOC100021710
uniprot id: K7E3M5
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:LOC100018556
gene id: 13616:LOC100018556
uniprot id: F6TJB1
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

13616:TBL3
gene id: 13616:TBL3
uniprot id: F7FYU7
names: Subcellular Location Annotation
messages: nucleolus

13616:ATP1B4
gene id: 13616:ATP1B4
uniprot id: F6SSM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

13616:CDK5R2
gene id: 13616:CDK5R2
uniprot id: A0A5F8H8P4
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

13616:LITAF
gene id: 13616:LITAF
uniprot id: A0A5F8GAB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

13616:BTBD10
gene id: 13616:BTBD10
uniprot id: A0A5F8GKR9
uniprot id: A0A5F8HDX5
names: Subcellular Location Annotation
messages: Cytoplasm

13616:CSF3R
gene id: 13616:CSF3R
uniprot id: F6ZY07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

13616:ADIPOR1
gene id: 13616:ADIPOR1
uniprot id: F7AV52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:MNAT1
gene id: 13616:MNAT1
uniprot id: F6PG98
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

13616:TM2D3
gene id: 13616:TM2D3
uniprot id: F7CV01
names: Subcellular Location Annotation
messages: Membrane

13616:LOC103100592
gene id: 13616:LOC103100592
uniprot id: F7G3S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DUS4L
gene id: 13616:DUS4L
uniprot id: F7F6S4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

13616:LOC100619160
gene id: 13616:LOC100619160
uniprot id: A0A5F8H995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GATA3
gene id: 13616:GATA3
uniprot id: F7BYS6
names: Subcellular Location Annotation
messages: Nucleus

13616:C6H9orf3
gene id: 13616:C6H9orf3
uniprot id: A0A5F8GQ86
names: Similarity
messages: Belongs to the peptidase M1 family.

13616:HOGA1
gene id: 13616:HOGA1
uniprot id: A0A5F8GMB5
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

13616:LOC100032185
gene id: 13616:LOC100032185
uniprot id: F6SNI6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

13616:LOC103097109
gene id: 13616:LOC103097109
uniprot id: F7B148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

13616:ATP6V1G3
gene id: 13616:ATP6V1G3
uniprot id: F7EFU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:LOC100010620
gene id: 13616:LOC100010620
uniprot id: A0A5F8HEK2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

13616:ERLIN1
gene id: 13616:ERLIN1
uniprot id: F7CJY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

13616:RGS5
gene id: 13616:RGS5
uniprot id: F7G7X1
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

13616:AACS
gene id: 13616:AACS
uniprot id: F7EI39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

13616:EIF3H
gene id: 13616:EIF3H
uniprot id: F6RA25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

13616:CDO1
gene id: 13616:CDO1
uniprot id: F6TXZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

13616:NFYB
gene id: 13616:NFYB
uniprot id: F6YET9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

13616:F13A1
gene id: 13616:F13A1
uniprot id: F6VTU1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

13616:GEMIN2
gene id: 13616:GEMIN2
uniprot id: A0A5F8G5H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

13616:MC2R
gene id: 13616:MC2R
uniprot id: F7CBR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

13616:LOC100618838
gene id: 13616:LOC100618838
uniprot id: F6Q311
names: Subcellular Location Annotation
messages: Membrane

13616:FAM160A2
gene id: 13616:FAM160A2
uniprot id: A0A5F8GT78
uniprot id: F7FCT7
names: Similarity
messages: Belongs to the FHIP family.

13616:EIF2S1
gene id: 13616:EIF2S1
uniprot id: F6RU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

13616:SLC37A1
gene id: 13616:SLC37A1
uniprot id: F6QZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

13616:NACC2
gene id: 13616:NACC2
uniprot id: F7E104
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC6A6
gene id: 13616:SLC6A6
uniprot id: K7E0U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

13616:TXK
gene id: 13616:TXK
uniprot id: F6ZAP5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:YPEL2
gene id: 13616:YPEL2
uniprot id: F7AS66
names: Similarity
messages: Belongs to the yippee family.

13616:SRRD
gene id: 13616:SRRD
uniprot id: A0A5F8GPP7
names: Similarity
messages: Belongs to the SRR1 family.

13616:LOC103103839
gene id: 13616:LOC103103839
uniprot id: K7E1P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

13616:LOC103104622
gene id: 13616:LOC103104622
uniprot id: F7DI29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

13616:PPP2R5A
gene id: 13616:PPP2R5A
uniprot id: A0A5F8H6J6
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

13616:MRAP
gene id: 13616:MRAP
uniprot id: A0A5F8GHV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:RGS4
gene id: 13616:RGS4
uniprot id: F7GHB2
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

13616:LOC100015220
gene id: 13616:LOC100015220
uniprot id: A0A5F8GBX2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

13616:ABCB11
gene id: 13616:ABCB11
uniprot id: F7ETR3
names: Subcellular Location Annotation
messages: Endosome

13616:LAPTM5
gene id: 13616:LAPTM5
uniprot id: A0A5F8H2B0
uniprot id: F6XZB7
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

13616:FGFR1OP2
gene id: 13616:FGFR1OP2
uniprot id: A0A5F8G9V1
uniprot id: F6YNF0
names: Similarity
messages: Belongs to the SIKE family.

13616:OPA1
gene id: 13616:OPA1
uniprot id: A0A5F8G2C2
uniprot id: A0A5F8HGH0
uniprot id: F7CFA6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

13616:C2H1orf43
gene id: 13616:C2H1orf43
uniprot id: A0A5F8GEY8
uniprot id: A0A5F8HL48
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

13616:RCAN2
gene id: 13616:RCAN2
uniprot id: A0A5F8G3C2
uniprot id: A0A5F8HJH5
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

13616:OAT
gene id: 13616:OAT
uniprot id: F7D3B5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

13616:CRHBP
gene id: 13616:CRHBP
uniprot id: F6WNR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

13616:LOC100018312
gene id: 13616:LOC100018312
uniprot id: A0A5F8GP71
names: Similarity
messages: Belongs to the cystatin family.

13616:ACKR4
gene id: 13616:ACKR4
uniprot id: F7GHG6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:NEUROD6
gene id: 13616:NEUROD6
uniprot id: F7BYF9
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

13616:CHRNA4
gene id: 13616:CHRNA4
uniprot id: F6QGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:SOD2
gene id: 13616:SOD2
uniprot id: F7GJS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

13616:RAB11FIP3
gene id: 13616:RAB11FIP3
uniprot id: A0A5F8GJ75
uniprot id: F7E6J7
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

13616:TRAPPC4
gene id: 13616:TRAPPC4
uniprot id: F7GJ67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

13616:LOC103103724
gene id: 13616:LOC103103724
uniprot id: K7E235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

13616:FKBP6
gene id: 13616:FKBP6
uniprot id: F6WS39
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

13616:RCL1
gene id: 13616:RCL1
uniprot id: A0A5F8GAE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

13616:L3HYPDH
gene id: 13616:L3HYPDH
uniprot id: K7E500
names: Similarity
messages: Belongs to the proline racemase family.

13616:FOXJ2
gene id: 13616:FOXJ2
uniprot id: F7BV32
names: Subcellular Location Annotation
messages: Nucleus

13616:C3H5orf22
gene id: 13616:C3H5orf22
uniprot id: F6UM79
names: Similarity
messages: Belongs to the UPF0489 family.

13616:SYNE3
gene id: 13616:SYNE3
uniprot id: A0A5F8G5L1
names: Similarity
messages: Belongs to the nesprin family.

13616:CLRN1
gene id: 13616:CLRN1
uniprot id: A0A5F8HGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

13616:DMRTA2
gene id: 13616:DMRTA2
uniprot id: F7CJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:ACAD9
gene id: 13616:ACAD9
uniprot id: F7GES9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:CCT4
gene id: 13616:CCT4
uniprot id: F7B657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:SOX9
gene id: 13616:SOX9
uniprot id: F7E3K1
names: Subcellular Location Annotation
messages: Nucleus

13616:FRK
gene id: 13616:FRK
uniprot id: F6Z7T8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:EXOSC9
gene id: 13616:EXOSC9
uniprot id: F7GJQ1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:STOML1
gene id: 13616:STOML1
uniprot id: A0A5F8HFG7
uniprot id: F7BDY3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

13616:LOC100024961
gene id: 13616:LOC100024961
uniprot id: F6X182
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:TCTA
gene id: 13616:TCTA
uniprot id: F7CSS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

13616:FGD6
gene id: 13616:FGD6
uniprot id: F6W6U6
names: Subcellular Location Annotation
messages: cytoskeleton

13616:TATDN2
gene id: 13616:TATDN2
uniprot id: F7BXM4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

13616:LRRC8C
gene id: 13616:LRRC8C
uniprot id: F7G4Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

13616:TWF1
gene id: 13616:TWF1
uniprot id: F7GD77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

13616:LOC103097444
gene id: 13616:LOC103097444
uniprot id: A0A5F8GA12
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100022115
gene id: 13616:LOC100022115
uniprot id: F6R532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

13616:ATXN10
gene id: 13616:ATXN10
uniprot id: F7EYF8
names: Function
names: Similarity
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

13616:PRPF31
gene id: 13616:PRPF31
uniprot id: K7E106
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

13616:TAF5
gene id: 13616:TAF5
uniprot id: F7DL63
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

13616:NEUROD1
gene id: 13616:NEUROD1
uniprot id: F7AUR1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:TMEM50B
gene id: 13616:TMEM50B
uniprot id: F6V201
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

13616:GAB3
gene id: 13616:GAB3
uniprot id: F7EDS3
names: Similarity
messages: Belongs to the GAB family.

13616:CA7
gene id: 13616:CA7
uniprot id: F6PGF8
uniprot id: F6PGJ3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:ATIC
gene id: 13616:ATIC
uniprot id: F6Z515
names: Similarity
messages: Belongs to the PurH family.

13616:KEG11 p01
gene id: 13616:KEG11_p01
uniprot id: Q65CI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

13616:IRX3
gene id: 13616:IRX3
uniprot id: F7FAB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:IL11RA
gene id: 13616:IL11RA
uniprot id: F6ZGE5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

13616:CMBL
gene id: 13616:CMBL
uniprot id: F7GD97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

13616:LOC100011560
gene id: 13616:LOC100011560
uniprot id: A0A5F8GDX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:KCNF1
gene id: 13616:KCNF1
uniprot id: F7D2C1
names: Subcellular Location Annotation
messages: Membrane

13616:MBOAT4
gene id: 13616:MBOAT4
uniprot id: A0A5F8GR95
names: Subcellular Location Annotation
messages: Membrane

13616:MNX1
gene id: 13616:MNX1
uniprot id: F6XG12
names: Subcellular Location Annotation
messages: Nucleus

13616:ZNF326
gene id: 13616:ZNF326
uniprot id: F7G549
names: Similarity
messages: Belongs to the AKAP95 family.

13616:LOC100015637
gene id: 13616:LOC100015637
uniprot id: F6TIE4
names: Similarity
messages: Belongs to the intermediate filament family.

13616:CNOT3
gene id: 13616:CNOT3
uniprot id: A0A5F8HAG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

13616:LOC103102448
gene id: 13616:LOC103102448
uniprot id: K7DZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

13616:LOC100012668
gene id: 13616:LOC100012668
uniprot id: F7GG98
names: Similarity
messages: Belongs to the 3-beta-HSD family.

13616:SLC15A1
gene id: 13616:SLC15A1
uniprot id: F7EJN7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

13616:ORC5
gene id: 13616:ORC5
uniprot id: F6SM08
names: Subcellular Location Annotation
messages: Nucleus

13616:GRHL3
gene id: 13616:GRHL3
uniprot id: F7FQ08
names: Subcellular Location Annotation
messages: Nucleus

13616:MBP
gene id: 13616:MBP
uniprot id: A0A5F8GHA3
uniprot id: A0A5F8HKF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

13616:EXOSC1
gene id: 13616:EXOSC1
uniprot id: F6XQF9
names: Subcellular Location Annotation
messages: Cytoplasm

13616:SHROOM4
gene id: 13616:SHROOM4
uniprot id: F7BBG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

13616:UXS1
gene id: 13616:UXS1
uniprot id: F7G4Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

13616:DCAF10
gene id: 13616:DCAF10
uniprot id: F6Q3V3
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

13616:FAM219A
gene id: 13616:FAM219A
uniprot id: A0A5F8GZ01
names: Similarity
messages: Belongs to the FAM219 family.

13616:TEKT4
gene id: 13616:TEKT4
uniprot id: F6VNC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

13616:COPS5
gene id: 13616:COPS5
uniprot id: F7ETC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

13616:VCAN
gene id: 13616:VCAN
uniprot id: F7CK30
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:HOMEZ
gene id: 13616:HOMEZ
uniprot id: F7CZK5
names: Subcellular Location Annotation
messages: Nucleus

13616:UCHL3
gene id: 13616:UCHL3
uniprot id: A0A5F8GPB4
uniprot id: A0A5F8HB82
names: Similarity
messages: Belongs to the peptidase C12 family.

13616:SLC35B1
gene id: 13616:SLC35B1
uniprot id: A0A5F8GQU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

13616:PTPN6
gene id: 13616:PTPN6
uniprot id: F7CWQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

13616:SLC25A15
gene id: 13616:SLC25A15
uniprot id: A0A5F8H400
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:NKD2
gene id: 13616:NKD2
uniprot id: F6S8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

13616:AMN
gene id: 13616:AMN
uniprot id: F7DTU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RNPEP
gene id: 13616:RNPEP
uniprot id: F6Y513
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:BCKDHA
gene id: 13616:BCKDHA
uniprot id: F7DH17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

13616:SMARCA5
gene id: 13616:SMARCA5
uniprot id: F6R7X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

13616:IQSEC1
gene id: 13616:IQSEC1
uniprot id: F7FG08
names: Similarity
messages: Belongs to the BRAG family.

13616:DDX1
gene id: 13616:DDX1
uniprot id: F6VNU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule

13616:NCBP1
gene id: 13616:NCBP1
uniprot id: A0A5F8GTQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

13616:MAST3
gene id: 13616:MAST3
uniprot id: F6VY61
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

13616:AIF1L
gene id: 13616:AIF1L
uniprot id: A0A5F8HC25
names: Subcellular Location Annotation
messages: ruffle membrane

13616:CITED2
gene id: 13616:CITED2
uniprot id: F6VSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

13616:FBN1
gene id: 13616:FBN1
uniprot id: F7CYW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:NPRL3
gene id: 13616:NPRL3
uniprot id: A0A5F8GM85
uniprot id: F6YMK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

13616:ADK
gene id: 13616:ADK
uniprot id: A0A5F8GHX5
uniprot id: F6WM42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

13616:C2H17orf62
gene id: 13616:C2H17orf62
uniprot id: A0A5F8HKT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:GNA14
gene id: 13616:GNA14
uniprot id: F7G1U7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

13616:AMBP
gene id: 13616:AMBP
uniprot id: F7D6H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: Secreted

13616:LOC100011182
gene id: 13616:LOC100011182
uniprot id: F6PX60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:LOC100018520
gene id: 13616:LOC100018520
uniprot id: F6SJ10
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

13616:KCNJ8
gene id: 13616:KCNJ8
uniprot id: A0A5F8GX62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

13616:KRR1
gene id: 13616:KRR1
uniprot id: F7A3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

13616:HTR2B
gene id: 13616:HTR2B
uniprot id: F7G7L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

13616:LOC100017133
gene id: 13616:LOC100017133
uniprot id: A0A5F8HBF7
uniprot id: F7ANY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:LSM14A
gene id: 13616:LSM14A
uniprot id: F7ALQ2
names: Similarity
messages: Belongs to the LSM14 family.

13616:HTR7
gene id: 13616:HTR7
uniprot id: F6PWX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PRPH
gene id: 13616:PRPH
uniprot id: F6UWF7
names: Similarity
messages: Belongs to the intermediate filament family.

13616:CSNK1G1
gene id: 13616:CSNK1G1
uniprot id: A0A5F8HH72
uniprot id: F7BZR5
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

13616:SEC23B
gene id: 13616:SEC23B
uniprot id: F6V3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

13616:LOC100027080
gene id: 13616:LOC100027080
uniprot id: F6SRY8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

13616:MIS18A
gene id: 13616:MIS18A
uniprot id: A0A5F8G4M6
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

13616:BLMH
gene id: 13616:BLMH
uniprot id: F6RU49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

13616:SLC23A1
gene id: 13616:SLC23A1
uniprot id: F7FSI2
names: Subcellular Location Annotation
messages: Membrane

13616:LAPTM4B
gene id: 13616:LAPTM4B
uniprot id: F6PFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: multivesicular body lumen
messages: multivesicular body membrane

13616:SLCO4A1
gene id: 13616:SLCO4A1
uniprot id: F7G693
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

13616:KCNH2
gene id: 13616:KCNH2
uniprot id: A0A5F8GYC7
uniprot id: F6ZK39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Membrane

13616:RGS1
gene id: 13616:RGS1
uniprot id: F7G556
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

13616:PCCA
gene id: 13616:PCCA
uniprot id: F7AYP6
names: Subcellular Location Annotation
messages: Mitochondrion matrix

13616:SLC44A4
gene id: 13616:SLC44A4
uniprot id: F7CZL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

13616:DDX49
gene id: 13616:DDX49
uniprot id: F7ECS2
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:SLC25A31
gene id: 13616:SLC25A31
uniprot id: F7FU45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:STK11
gene id: 13616:STK11
uniprot id: K7E2U8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

13616:RGS9BP
gene id: 13616:RGS9BP
uniprot id: F7EZP3
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

13616:SLC23A3
gene id: 13616:SLC23A3
uniprot id: F6XFG6
names: Subcellular Location Annotation
messages: Membrane

13616:CAD
gene id: 13616:CAD
uniprot id: A0A5F8GK19
uniprot id: F7E0R2
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

13616:HM13
gene id: 13616:HM13
uniprot id: A0A5F8HH85
uniprot id: F6VUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

13616:PCSK1
gene id: 13616:PCSK1
uniprot id: F7GI61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

13616:CPPED1
gene id: 13616:CPPED1
uniprot id: A0A5F8GIR8
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

13616:TMPO
gene id: 13616:TMPO
uniprot id: A0A5F8G4Y9
uniprot id: F6X3L4
names: Similarity
messages: Belongs to the LEM family.

13616:XPNPEP2
gene id: 13616:XPNPEP2
uniprot id: F7EVW3
names: Similarity
messages: Belongs to the peptidase M24B family.

13616:CDH20
gene id: 13616:CDH20
uniprot id: F7C1R7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:SLC35A4
gene id: 13616:SLC35A4
uniprot id: F6SDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

13616:MYOZ1
gene id: 13616:MYOZ1
uniprot id: F6WB86
names: Similarity
messages: Belongs to the myozenin family.

13616:ESR1
gene id: 13616:ESR1
uniprot id: F7CHI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

13616:LOC100010915
gene id: 13616:LOC100010915
uniprot id: F7EGS5
names: Subcellular Location Annotation
messages: Membrane

13616:MDGA2
gene id: 13616:MDGA2
uniprot id: A0A5F8G7I5
uniprot id: A0A5F8GJL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100031977
gene id: 13616:LOC100031977
uniprot id: F6YJC5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:HOXD9
gene id: 13616:HOXD9
uniprot id: F7A9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:KIAA1147
gene id: 13616:KIAA1147
uniprot id: F6VF55
names: Similarity
messages: Belongs to the DENND11 family.

13616:SLC13A3
gene id: 13616:SLC13A3
uniprot id: F6TWV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

13616:FAM175B
gene id: 13616:FAM175B
uniprot id: A0A5F8H3A9
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100015889
gene id: 13616:LOC100015889
uniprot id: A0A5F8HKY3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

13616:TMEM183A
gene id: 13616:TMEM183A
uniprot id: F6ZGV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

13616:KCNK17
gene id: 13616:KCNK17
uniprot id: A0A5F8G871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:GPBP1L1
gene id: 13616:GPBP1L1
uniprot id: A0A5F8GP61
uniprot id: F7DFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

13616:SNED1
gene id: 13616:SNED1
uniprot id: F7B7B4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100030172
gene id: 13616:LOC100030172
uniprot id: F6WED1
names: Subcellular Location Annotation
messages: Membrane

13616:STARD3
gene id: 13616:STARD3
uniprot id: F7DZ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

13616:KDM4B
gene id: 13616:KDM4B
uniprot id: A0A5F8G415
uniprot id: F7EPQ5
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

13616:VIP
gene id: 13616:VIP
uniprot id: F7FG24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

13616:NDUFB9
gene id: 13616:NDUFB9
uniprot id: A0A5F8HCS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:NKIRAS2
gene id: 13616:NKIRAS2
uniprot id: F7GGS1
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

13616:SLC46A2
gene id: 13616:SLC46A2
uniprot id: F6V5F1
names: Subcellular Location Annotation
messages: Membrane

13616:ODC1
gene id: 13616:ODC1
uniprot id: F7G6Y2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

13616:RAD51D
gene id: 13616:RAD51D
uniprot id: F7ECH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

13616:LOC103094399
gene id: 13616:LOC103094399
uniprot id: A0A5F8GK91
names: Similarity
messages: Belongs to the cystatin family.

13616:LOC100023722
gene id: 13616:LOC100023722
uniprot id: F7AWM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

13616:LOC100010569
gene id: 13616:LOC100010569
uniprot id: A0A5F8GCI9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

13616:IRAK1BP1
gene id: 13616:IRAK1BP1
uniprot id: F6XBJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

13616:MNS1
gene id: 13616:MNS1
uniprot id: F7EL05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

13616:NUCB2
gene id: 13616:NUCB2
uniprot id: F6XCE7
names: Similarity
messages: Belongs to the nucleobindin family.

13616:TOPAZ1
gene id: 13616:TOPAZ1
uniprot id: K7E306
names: Function
names: Subcellular Location Annotation
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
messages: cytosol

13616:GC
gene id: 13616:GC
uniprot id: A0A5F8H662
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

13616:KDM1A
gene id: 13616:KDM1A
uniprot id: F7D7I0
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

13616:DEGS2
gene id: 13616:DEGS2
uniprot id: A0A5F8GGF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:SFRP2
gene id: 13616:SFRP2
uniprot id: F7GHD3
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100016658
gene id: 13616:LOC100016658
uniprot id: F7FR20
names: Similarity
messages: Belongs to the FAM83 family.

13616:VN2R644
gene id: 13616:VN2R644
uniprot id: F7BFK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PNLDC1
gene id: 13616:PNLDC1
uniprot id: A0A5F8GHL9
uniprot id: F7EE59
names: Similarity
messages: Belongs to the CAF1 family.

13616:LOC100013846
gene id: 13616:LOC100013846
uniprot id: F6X1G4
names: Similarity
messages: Belongs to the intermediate filament family.

13616:RHBDF2
gene id: 13616:RHBDF2
uniprot id: F7DQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

13616:MTMR10
gene id: 13616:MTMR10
uniprot id: F7CC74
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:TMEFF1
gene id: 13616:TMEFF1
uniprot id: F7CTI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CEBPE
gene id: 13616:CEBPE
uniprot id: F6QJH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

13616:GJB5
gene id: 13616:GJB5
uniprot id: F7EJS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:CAP2
gene id: 13616:CAP2
uniprot id: F7F511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

13616:RRP8
gene id: 13616:RRP8
uniprot id: A0A5F8G639
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

13616:MRPL3
gene id: 13616:MRPL3
uniprot id: F7G715
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

13616:LOC100011249
gene id: 13616:LOC100011249
uniprot id: A0A5F8GLY8
names: Subcellular Location Annotation
messages: Membrane

13616:LGI3
gene id: 13616:LGI3
uniprot id: F7AWE8
names: Subcellular Location Annotation
messages: Secreted

13616:LANCL3
gene id: 13616:LANCL3
uniprot id: F6U2W0
names: Similarity
messages: Belongs to the LanC-like protein family.

13616:SHTN1
gene id: 13616:SHTN1
uniprot id: A0A5F8GV46
uniprot id: F7FNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

13616:TMEM106A
gene id: 13616:TMEM106A
uniprot id: F7CF63
names: Similarity
messages: Belongs to the TMEM106 family.

13616:PSMA7
gene id: 13616:PSMA7
uniprot id: F6WS89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:TRAF4
gene id: 13616:TRAF4
uniprot id: A0A5F8GY95
uniprot id: F6RYQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

13616:SRPRA
gene id: 13616:SRPRA
uniprot id: K7E5M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

13616:GAA
gene id: 13616:GAA
uniprot id: F7GEC6
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:OSBPL8
gene id: 13616:OSBPL8
uniprot id: A0A5F8H8Y3
uniprot id: F7FJJ1
names: Similarity
messages: Belongs to the OSBP family.

13616:ABCC8
gene id: 13616:ABCC8
uniprot id: F6XVA7
names: Subunit
messages: Interacts with KCNJ11.

13616:MSANTD3
gene id: 13616:MSANTD3
uniprot id: A0A5F8GMY3
names: Similarity
messages: Belongs to the MSANTD3 family.

13616:ADCK4
gene id: 13616:ADCK4
uniprot id: F6ZGH1
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

13616:DCTD
gene id: 13616:DCTD
uniprot id: F6UWJ2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

13616:LOC100021972
gene id: 13616:LOC100021972
uniprot id: A0A5F8GXG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PRIMPOL
gene id: 13616:PRIMPOL
uniprot id: F6UQC2
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

13616:NUP50
gene id: 13616:NUP50
uniprot id: A0A5F8G4P9
uniprot id: F6SHF0
names: Subcellular Location Annotation
messages: nuclear pore complex

13616:LHFPL1
gene id: 13616:LHFPL1
uniprot id: F6ZDS8
names: Subcellular Location Annotation
messages: Membrane

13616:OTX1
gene id: 13616:OTX1
uniprot id: A0A5F8G3F7
names: Subcellular Location Annotation
messages: Nucleus

13616:SCMH1
gene id: 13616:SCMH1
uniprot id: F6WVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

13616:PPIB
gene id: 13616:PPIB
uniprot id: F7BZB1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:CSGALNACT1
gene id: 13616:CSGALNACT1
uniprot id: F6R8K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

13616:ZC2HC1C
gene id: 13616:ZC2HC1C
uniprot id: F6SKX5
names: Similarity
messages: Belongs to the ZC2HC1 family.

13616:SEMA5A
gene id: 13616:SEMA5A
uniprot id: F6U008
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DNASE2
gene id: 13616:DNASE2
uniprot id: F6VJD5
names: Similarity
messages: Belongs to the DNase II family.

13616:NFS1
gene id: 13616:NFS1
uniprot id: F7BBK5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

13616:METAP1
gene id: 13616:METAP1
uniprot id: A0A5F8H2S0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

13616:METTL2A
gene id: 13616:METTL2A
uniprot id: F6W5L3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

13616:PHOX2B
gene id: 13616:PHOX2B
uniprot id: F7A1R1
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC2A3
gene id: 13616:SLC2A3
uniprot id: F7BV22
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:PDPR
gene id: 13616:PDPR
uniprot id: F6ZEM0
names: Similarity
messages: Belongs to the GcvT family.

13616:HMX2
gene id: 13616:HMX2
uniprot id: F7GAL2
names: Subcellular Location Annotation
messages: Nucleus

13616:GDE1
gene id: 13616:GDE1
uniprot id: A0A5F8GB52
uniprot id: F7FE75
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

13616:GPR83
gene id: 13616:GPR83
uniprot id: F6SGG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:CMTR1
gene id: 13616:CMTR1
uniprot id: F7DTG4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

13616:CDKN2A
gene id: 13616:CDKN2A
uniprot id: O77617
uniprot id: O77618
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity).
messages: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
messages: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).
messages: Cytoplasm
messages: Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1 and COMMD1. Interacts with CDKN2AIP and E4F1. Interacts with CDK5RAP3 and MDM2; form a ternary complex involved in regulation of p53/TP53. Interacts with NOP53; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin-mediated proteasomal degradation (By similarity). Interacts with TTF1 (via the N-terminal region (NRD) and a C-terminal region); the interaction is direct and inhibits the nucleolar localization of TTF1 (By similarity).
messages: Expressed predominantly in lung and testis. In the testis, restricted to germ cells in the seminiferous epithelium. Not detected in premeiotic spermatogonia but high levels found in postmeiotic spermatids. In primary tumors, low levels detected in melanocytic hyperplasias. Higher levels found in non-metastatic and metastatic melanomas.
messages: Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2 (By similarity).
messages: Nucleus
messages: Produced by alternative initiation at Met-35 of isoform 1.
messages: The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to cyclin-dependent kinase inhibitor 2A (AC O77617) which is encoded by the same gene.
messages: The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC O77618) which is encoded by the same gene.
messages: Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardless of the absence of lysine residues. Ubiquitination leads to its proteasomal degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.
messages: Ubiquitously expressed. In the testis, expressed in both somatic and germ cells. Not detected in premeiotic spermatogonia but expressed in both meiotic and postmeiotic cells. In primary tumors, low levels detected in melanocytic hyperplasias. Higher levels found in non-metastatic and metastatic melanomas.
messages: nucleolus
messages: nucleoplasm

13616:ATP6V1H
gene id: 13616:ATP6V1H
uniprot id: A0A5F8HGQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:SYT16
gene id: 13616:SYT16
uniprot id: F6RG93
names: Similarity
messages: Belongs to the synaptotagmin family.

13616:LOC100022970
gene id: 13616:LOC100022970
uniprot id: F7FNQ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ATP13A2
gene id: 13616:ATP13A2
uniprot id: F6YG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

13616:NOX5
gene id: 13616:NOX5
uniprot id: A7E3P2
names: Subcellular Location Annotation
messages: Membrane

13616:FAM161A
gene id: 13616:FAM161A
uniprot id: A0A5F8HEL8
names: Similarity
messages: Belongs to the FAM161 family.

13616:LTBR
gene id: 13616:LTBR
uniprot id: A0A5F8G7Q0
uniprot id: F7G4F9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PCSK5
gene id: 13616:PCSK5
uniprot id: A0A5F8GCB9
names: Similarity
messages: Belongs to the peptidase S8 family.

13616:ASXL3
gene id: 13616:ASXL3
uniprot id: A0A5F8H355
uniprot id: F7CIA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

13616:ASXL1
gene id: 13616:ASXL1
uniprot id: F6RWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

13616:SNRPD1
gene id: 13616:SNRPD1
uniprot id: F7G2W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

13616:SAMD4A
gene id: 13616:SAMD4A
uniprot id: A0A5F8GUC5
uniprot id: A0A5F8GVQ6
uniprot id: A0A5F8HE05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

13616:MCUR1
gene id: 13616:MCUR1
uniprot id: A0A5F8GLK7
uniprot id: A0A5F8GLY0
names: Similarity
messages: Belongs to the CCDC90 family.

13616:CMPK1
gene id: 13616:CMPK1
uniprot id: F7AP82
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

13616:SEH1L
gene id: 13616:SEH1L
uniprot id: A0A5F8GFA8
uniprot id: F7CBH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

13616:DSTN
gene id: 13616:DSTN
uniprot id: F7D0S2
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

13616:ANAPC2
gene id: 13616:ANAPC2
uniprot id: F6XXR8
names: Similarity
messages: Belongs to the cullin family.

13616:LOC100015966
gene id: 13616:LOC100015966
uniprot id: F7F9Q2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:STOM
gene id: 13616:STOM
uniprot id: A0A5F8GY80
uniprot id: F6UAH2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

13616:FOXA3
gene id: 13616:FOXA3
uniprot id: F6WDS2
names: Subcellular Location Annotation
messages: Nucleus

13616:GALNT2
gene id: 13616:GALNT2
uniprot id: F7B0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:ENO4
gene id: 13616:ENO4
uniprot id: A0A5F8G414
names: Similarity
messages: Belongs to the enolase family.

13616:APOBEC1
gene id: 13616:APOBEC1
uniprot id: Q9TUI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 Zn(2+) ion per subunit.
messages: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
messages: Cytoplasm
messages: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Interacts with HNRPAB and SYNCRIP.

13616:CDCA8
gene id: 13616:CDCA8
uniprot id: F7E4K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

13616:LOC100010333
gene id: 13616:LOC100010333
uniprot id: A0A5F8GX51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

13616:NSUN4
gene id: 13616:NSUN4
uniprot id: F6RHT5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

13616:AGTR2
gene id: 13616:AGTR2
uniprot id: F7C222
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

13616:CAMK2N2
gene id: 13616:CAMK2N2
uniprot id: F7F029
names: Similarity
messages: Belongs to the CAMK2N family.

13616:WNT10A
gene id: 13616:WNT10A
uniprot id: F6SGX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:DBNL
gene id: 13616:DBNL
uniprot id: A0A5F8GM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

13616:MAP1LC3A
gene id: 13616:MAP1LC3A
uniprot id: F7CYB7
names: Similarity
messages: Belongs to the ATG8 family.

13616:LOC100020587
gene id: 13616:LOC100020587
uniprot id: F7CSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

13616:VPS29
gene id: 13616:VPS29
uniprot id: A0A5F8GJK1
uniprot id: F6XX15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

13616:TSEN2
gene id: 13616:TSEN2
uniprot id: F7FEC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

13616:LOC100017091
gene id: 13616:LOC100017091
uniprot id: F6YZH5
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

13616:NSMCE1
gene id: 13616:NSMCE1
uniprot id: F6S2Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

13616:FAM163B
gene id: 13616:FAM163B
uniprot id: F7CRK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

13616:LOC100032867
gene id: 13616:LOC100032867
uniprot id: K7DZP7
names: Subcellular Location Annotation
messages: Membrane

13616:IL6R
gene id: 13616:IL6R
uniprot id: F6Z3Z1
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

13616:CADM3
gene id: 13616:CADM3
uniprot id: A0A5F8GNW5
names: Similarity
messages: Belongs to the nectin family.

13616:PRRC1
gene id: 13616:PRRC1
uniprot id: A0A5F8GKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

13616:LOC100023923
gene id: 13616:LOC100023923
uniprot id: F6U0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:monDomV1R1230
gene id: 13616:monDomV1R1230
uniprot id: A0A5F8GPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NNT
gene id: 13616:NNT
uniprot id: F7C0X4
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

13616:GJA8
gene id: 13616:GJA8
uniprot id: F7BI06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:PDGFB
gene id: 13616:PDGFB
uniprot id: F7BJK8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:ITIH2
gene id: 13616:ITIH2
uniprot id: F7CI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

13616:LOC100029767
gene id: 13616:LOC100029767
uniprot id: F7A7I3
names: Similarity
messages: Belongs to the actin family.

13616:MRPS31
gene id: 13616:MRPS31
uniprot id: F6S8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

13616:NAPG
gene id: 13616:NAPG
uniprot id: F7CB23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

13616:BMP6
gene id: 13616:BMP6
uniprot id: F6UAT4
names: Similarity
messages: Belongs to the TGF-beta family.

13616:TATDN1
gene id: 13616:TATDN1
uniprot id: F6SPH7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

13616:SH3GL3
gene id: 13616:SH3GL3
uniprot id: A0A5F8GI38
uniprot id: A0A5F8H9K1
uniprot id: F7DXD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

13616:SLITRK4
gene id: 13616:SLITRK4
uniprot id: F7BG21
names: Similarity
messages: Belongs to the SLITRK family.

13616:GABRE
gene id: 13616:GABRE
uniprot id: F6TKY5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:TMC7
gene id: 13616:TMC7
uniprot id: F6ZSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

13616:CFAP206
gene id: 13616:CFAP206
uniprot id: F6PUG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

13616:LOC103096027
gene id: 13616:LOC103096027
uniprot id: F7FXN7
names: Similarity
messages: Belongs to the MS4A family.

13616:LOC100024559
gene id: 13616:LOC100024559
uniprot id: F6YSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CETN2
gene id: 13616:CETN2
uniprot id: A0A5F8HJP8
names: Similarity
messages: Belongs to the centrin family.

13616:NIT1
gene id: 13616:NIT1
uniprot id: F7CHA1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

13616:ITGA6
gene id: 13616:ITGA6
uniprot id: F7GL63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:MON1A
gene id: 13616:MON1A
uniprot id: F7EIN6
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

13616:APOA4
gene id: 13616:APOA4
uniprot id: F6TDB8
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

13616:ITGB1
gene id: 13616:ITGB1
uniprot id: F7GAX7
uniprot id: K7E435
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

13616:NUP107
gene id: 13616:NUP107
uniprot id: F7FQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

13616:MEPCE
gene id: 13616:MEPCE
uniprot id: F6R6T5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

13616:CDIPT
gene id: 13616:CDIPT
uniprot id: F7AH47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

13616:LOC100032604
gene id: 13616:LOC100032604
uniprot id: K7E5P0
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:SMPD1
gene id: 13616:SMPD1
uniprot id: F7FD53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

13616:GRB7
gene id: 13616:GRB7
uniprot id: F6WKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

13616:HMGCL
gene id: 13616:HMGCL
uniprot id: F6Z184
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

13616:GRIK3
gene id: 13616:GRIK3
uniprot id: F7CFG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:TMEM123
gene id: 13616:TMEM123
uniprot id: F7GG72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

13616:VN2R554
gene id: 13616:VN2R554
uniprot id: A0A5F8GWZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100010526
gene id: 13616:LOC100010526
uniprot id: F6Q4E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

13616:SLC16A6
gene id: 13616:SLC16A6
uniprot id: F6W8B1
names: Subcellular Location Annotation
messages: Membrane

13616:GPR50
gene id: 13616:GPR50
uniprot id: A0A5F8GJ49
uniprot id: A0A5F8GV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GADL1
gene id: 13616:GADL1
uniprot id: F7CF79
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

13616:RPL34
gene id: 13616:RPL34
uniprot id: F6ZBY0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

13616:ASCC3
gene id: 13616:ASCC3
uniprot id: F7FTH1
names: Similarity
messages: Belongs to the helicase family.

13616:DMRTA1
gene id: 13616:DMRTA1
uniprot id: F7GJE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:ADRA1D
gene id: 13616:ADRA1D
uniprot id: F6S411
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

13616:B2M
gene id: 13616:B2M
uniprot id: F7G5N8
uniprot id: Q864T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

13616:GLE1
gene id: 13616:GLE1
uniprot id: F7E1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

13616:OAZ1
gene id: 13616:OAZ1
uniprot id: F6TQ50
names: Similarity
messages: Belongs to the ODC antizyme family.

13616:PLOD2
gene id: 13616:PLOD2
uniprot id: F6TJE3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:OSBPL6
gene id: 13616:OSBPL6
uniprot id: A0A5F8GRY6
names: Similarity
messages: Belongs to the OSBP family.

13616:TMEM54
gene id: 13616:TMEM54
uniprot id: A0A5F8HCP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

13616:CCNB2
gene id: 13616:CCNB2
uniprot id: F7CU79
names: Similarity
messages: Belongs to the cyclin family.

13616:CYFIP1
gene id: 13616:CYFIP1
uniprot id: F6XLX5
names: Similarity
messages: Belongs to the CYFIP family.

13616:RDX
gene id: 13616:RDX
uniprot id: A0A5F8GK37
uniprot id: A0A5F8HFM6
uniprot id: F7E8X5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

13616:LOC100025850
gene id: 13616:LOC100025850
uniprot id: F6QBV2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:COQ6
gene id: 13616:COQ6
uniprot id: F7AKV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

13616:NEDD9
gene id: 13616:NEDD9
uniprot id: A0A5F8G302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

13616:CTNNB1
gene id: 13616:CTNNB1
uniprot id: F6SRK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

13616:AMIGO3
gene id: 13616:AMIGO3
uniprot id: F6UY13
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

13616:ROGDI
gene id: 13616:ROGDI
uniprot id: F7AI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Perikaryon
messages: Presynapse
messages: synaptic vesicle

13616:MLH1
gene id: 13616:MLH1
uniprot id: F7GA57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

13616:VN2R506
gene id: 13616:VN2R506
uniprot id: F6QLA7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TPD52L2
gene id: 13616:TPD52L2
uniprot id: A0A5F8G6R7
uniprot id: A0A5F8GEA6
uniprot id: A0A5F8GID4
uniprot id: A0A5F8GW98
uniprot id: F6Y0L9
names: Similarity
messages: Belongs to the TPD52 family.

13616:PGAP1
gene id: 13616:PGAP1
uniprot id: F7CE20
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100013013
gene id: 13616:LOC100013013
uniprot id: A0A5F8H0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ATL2
gene id: 13616:ATL2
uniprot id: F7CC99
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

13616:LOC100019460
gene id: 13616:LOC100019460
uniprot id: F7FG79
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:PGR
gene id: 13616:PGR
uniprot id: A0A5F8GJ62
uniprot id: F6Y601
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Nucleus
messages: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues.

13616:IMPDH2
gene id: 13616:IMPDH2
uniprot id: A0A5F8GE87
uniprot id: F7DTY4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

13616:NCAM1
gene id: 13616:NCAM1
uniprot id: A0A5F8HAV9
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

13616:CLCC1
gene id: 13616:CLCC1
uniprot id: F7DG03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

13616:RUVBL2
gene id: 13616:RUVBL2
uniprot id: A0A5F8HDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

13616:AAR2
gene id: 13616:AAR2
uniprot id: F7BCP7
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

13616:LOC100026007
gene id: 13616:LOC100026007
uniprot id: F7D2Z8
names: Similarity
messages: Belongs to the MHC class II family.

13616:EXOC3L4
gene id: 13616:EXOC3L4
uniprot id: F7CNI2
names: Similarity
messages: Belongs to the SEC6 family.

13616:CHRNE
gene id: 13616:CHRNE
uniprot id: A0A5F8HBH8
uniprot id: A0A5F8HCL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:LOC107648921
gene id: 13616:LOC107648921
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:KRT35
gene id: 13616:KRT35
uniprot id: F7ERN9
names: Similarity
messages: Belongs to the intermediate filament family.

13616:RFLB
gene id: 13616:RFLB
uniprot id: A0A5F8G4Z5
uniprot id: B1AAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

13616:MRPS7
gene id: 13616:MRPS7
uniprot id: F7FCF7
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

13616:DNMT3L
gene id: 13616:DNMT3L
uniprot id: A0A5F8HBK3
uniprot id: F6UJ13
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100010920
gene id: 13616:LOC100010920
uniprot id: F7ESQ8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:SEPT9
gene id: 13616:SEPT9
uniprot id: F6T758
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

13616:NEFM
gene id: 13616:NEFM
uniprot id: F7BYP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon
messages: cytoskeleton

13616:ESRP1
gene id: 13616:ESRP1
uniprot id: A0A5F8GFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

13616:PABPN1
gene id: 13616:PABPN1
uniprot id: F6U9B0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:LMNA
gene id: 13616:LMNA
uniprot id: F6V6C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

13616:DENND5B
gene id: 13616:DENND5B
uniprot id: F6W2Y5
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SERPINI2
gene id: 13616:SERPINI2
uniprot id: F7C1V8
names: Similarity
messages: Belongs to the serpin family.

13616:NPC1L1
gene id: 13616:NPC1L1
uniprot id: F7D6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

13616:CTSH
gene id: 13616:CTSH
uniprot id: F6RXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:SMAD6
gene id: 13616:SMAD6
uniprot id: F6RFA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:MC4R
gene id: 13616:MC4R
uniprot id: A8QXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

13616:SEPSECS
gene id: 13616:SEPSECS
uniprot id: F6VAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

13616:KCNN2
gene id: 13616:KCNN2
uniprot id: F7E0I4
names: Subcellular Location Annotation
messages: Membrane

13616:LOC103100524
gene id: 13616:LOC103100524
uniprot id: F7EED4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PLOD3
gene id: 13616:PLOD3
uniprot id: F7ERJ3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:CD38
gene id: 13616:CD38
uniprot id: A0A5F8H8N2
uniprot id: F6ZFL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

13616:FREM2
gene id: 13616:FREM2
uniprot id: F6SBL8
names: Similarity
messages: Belongs to the FRAS1 family.

13616:ATAT1
gene id: 13616:ATAT1
uniprot id: A0A5F8G386
uniprot id: A0A5F8HD97
uniprot id: A0A5F8HK89
uniprot id: F6R6N6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

13616:GJD4
gene id: 13616:GJD4
uniprot id: A0A5F8GLA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:TMEM131
gene id: 13616:TMEM131
uniprot id: A0A5F8G6F3
names: Similarity
messages: Belongs to the TMEM131 family.

13616:ELAC1
gene id: 13616:ELAC1
uniprot id: F7AQD1
names: Subunit
messages: Homodimer.

13616:LOC103093835
gene id: 13616:LOC103093835
uniprot id: A0A5F8H5M6
names: Similarity
messages: Belongs to the MHC class I family.

13616:AK1
gene id: 13616:AK1
uniprot id: A0A5F8G8W5
uniprot id: A0A5F8HBA4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

13616:LOC100019817
gene id: 13616:LOC100019817
uniprot id: A0A5F8G6G9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:LOC100009955
gene id: 13616:LOC100009955
uniprot id: F6TAE7
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

13616:LOC100026277
gene id: 13616:LOC100026277
uniprot id: F6PG40
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:TRNAU1AP
gene id: 13616:TRNAU1AP
uniprot id: F7F4Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

13616:BCAP29
gene id: 13616:BCAP29
uniprot id: A0A5F8GQT6
uniprot id: F7A5H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

13616:TAS1R3
gene id: 13616:TAS1R3
uniprot id: F7B3I8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ADGRF5
gene id: 13616:ADGRF5
uniprot id: A0A5F8G938
uniprot id: F7DA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

13616:ETFA
gene id: 13616:ETFA
uniprot id: F7CUV6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

13616:SMC2
gene id: 13616:SMC2
uniprot id: A0A5F8G8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

13616:PBX2
gene id: 13616:PBX2
uniprot id: F6YKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

13616:SLCO2A1
gene id: 13616:SLCO2A1
uniprot id: F7BQX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:E2F6
gene id: 13616:E2F6
uniprot id: F7BB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:PLPPR5
gene id: 13616:PLPPR5
uniprot id: F7FYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:RPA1
gene id: 13616:RPA1
uniprot id: F6YRP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

13616:PTAR1
gene id: 13616:PTAR1
uniprot id: F7EJ46
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

13616:SLC1A3
gene id: 13616:SLC1A3
uniprot id: A0A5F8GBT1
uniprot id: F7FKB2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:SSU72
gene id: 13616:SSU72
uniprot id: F7GEV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

13616:SLC52A3
gene id: 13616:SLC52A3
uniprot id: F6Z2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

13616:SNTA1
gene id: 13616:SNTA1
uniprot id: F6PP33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

13616:VN2R539
gene id: 13616:VN2R539
uniprot id: F6W427
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CHSY1
gene id: 13616:CHSY1
uniprot id: F7ALM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

13616:FZR1
gene id: 13616:FZR1
uniprot id: F6PS44
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

13616:STARD8
gene id: 13616:STARD8
uniprot id: A0A5F8H0U1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:PARD6G
gene id: 13616:PARD6G
uniprot id: A0A5F8H752
uniprot id: F7E002
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

13616:GEM
gene id: 13616:GEM
uniprot id: F7B0E6
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

13616:TPMT
gene id: 13616:TPMT
uniprot id: F6XB36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

13616:PTGR1
gene id: 13616:PTGR1
uniprot id: F6U6I4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

13616:RPS11
gene id: 13616:RPS11
uniprot id: F7GIM6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

13616:CMPK2
gene id: 13616:CMPK2
uniprot id: F7ASM8
names: Similarity
messages: Belongs to the thymidylate kinase family.

13616:LASP1
gene id: 13616:LASP1
uniprot id: F6WDS9
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

13616:MCRIP2
gene id: 13616:MCRIP2
uniprot id: F7D1U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

13616:C3H8orf82
gene id: 13616:C3H8orf82
uniprot id: A0A5F8GQL4
names: Similarity
messages: Belongs to the UPF0598 family.

13616:STAG1
gene id: 13616:STAG1
uniprot id: F7GD67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

13616:GORASP1
gene id: 13616:GORASP1
uniprot id: K7DZF6
names: Similarity
messages: Belongs to the GORASP family.

13616:SLC5A12
gene id: 13616:SLC5A12
uniprot id: F7AKQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:LOC100024622
gene id: 13616:LOC100024622
uniprot id: F7DEM8
names: Subcellular Location Annotation
messages: Membrane

13616:AZIN1
gene id: 13616:AZIN1
uniprot id: F6T425
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

13616:FGF19
gene id: 13616:FGF19
uniprot id: F6VVN7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:INSIG2
gene id: 13616:INSIG2
uniprot id: A0A5F8G5H3
uniprot id: A0A5F8GA97
uniprot id: F6US40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

13616:DHRS4
gene id: 13616:DHRS4
uniprot id: A0A5F8GSE2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:SFMBT2
gene id: 13616:SFMBT2
uniprot id: F7E6I1
names: Subcellular Location Annotation
messages: Nucleus

13616:SATB2
gene id: 13616:SATB2
uniprot id: F7E1V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

13616:PPME1
gene id: 13616:PPME1
uniprot id: F7EE69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

13616:LOC100010349
gene id: 13616:LOC100010349
uniprot id: F7FWN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

13616:MOXD1
gene id: 13616:MOXD1
uniprot id: F7E0X4
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

13616:MOG
gene id: 13616:MOG
uniprot id: F6ZHT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

13616:TMEM200A
gene id: 13616:TMEM200A
uniprot id: A0A5F8GV59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

13616:ZDHHC13
gene id: 13616:ZDHHC13
uniprot id: F7BQD7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:IL12A
gene id: 13616:IL12A
uniprot id: F6T5A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

13616:CAMK2A
gene id: 13616:CAMK2A
uniprot id: F6QSC1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

13616:SCOC
gene id: 13616:SCOC
uniprot id: F6V246
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

13616:GSS
gene id: 13616:GSS
uniprot id: F7G4W7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

13616:ST14
gene id: 13616:ST14
uniprot id: F7ASK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ARRDC3
gene id: 13616:ARRDC3
uniprot id: F6YRB9
names: Similarity
messages: Belongs to the arrestin family.

13616:PDGFA
gene id: 13616:PDGFA
uniprot id: A0A5F8GD53
uniprot id: A0A5F8GF15
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:TNFSF11
gene id: 13616:TNFSF11
uniprot id: F7BYM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

13616:F12
gene id: 13616:F12
uniprot id: F6UQB2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:STMN4
gene id: 13616:STMN4
uniprot id: A0A5F8GBD4
uniprot id: F6ZRY0
names: Similarity
messages: Belongs to the stathmin family.

13616:MCHR2
gene id: 13616:MCHR2
uniprot id: F7FT78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FAM110C
gene id: 13616:FAM110C
uniprot id: F6Y1F9
names: Similarity
messages: Belongs to the FAM110 family.

13616:CCDC85C
gene id: 13616:CCDC85C
uniprot id: A0A5F8H5G2
uniprot id: F6QKS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

13616:WNT9B
gene id: 13616:WNT9B
uniprot id: A0A5F8G2P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:CA5B
gene id: 13616:CA5B
uniprot id: F6XEV7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:PSMF1
gene id: 13616:PSMF1
uniprot id: A0A5F8H5X4
uniprot id: F6UUG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

13616:LOC100018337
gene id: 13616:LOC100018337
uniprot id: F6UBZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:AMACR
gene id: 13616:AMACR
uniprot id: F7BZS2
names: Similarity
messages: Belongs to the CoA-transferase III family.

13616:ATP11C
gene id: 13616:ATP11C
uniprot id: A0A5F8GM80
uniprot id: A0A5F8GY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:AZIN2
gene id: 13616:AZIN2
uniprot id: F6VZY0
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

13616:KANSL2
gene id: 13616:KANSL2
uniprot id: F6QBP6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

13616:BSG
gene id: 13616:BSG
uniprot id: F7E424
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lateral cell membrane

13616:INSL3
gene id: 13616:INSL3
uniprot id: A0A5F8HAP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

13616:MCPH1
gene id: 13616:MCPH1
uniprot id: A0A5F8HGF8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

13616:RAP2C
gene id: 13616:RAP2C
uniprot id: F6XZ48
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

13616:RNF8
gene id: 13616:RNF8
uniprot id: A0A5F8GGK1
uniprot id: A0A5F8GW89
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

13616:LOC100030436
gene id: 13616:LOC100030436
uniprot id: F7BRF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TRIQK
gene id: 13616:TRIQK
uniprot id: F7BU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PTER
gene id: 13616:PTER
uniprot id: F6Y8J3
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ACE2
gene id: 13616:ACE2
uniprot id: F6WXR7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

13616:LOC100011118
gene id: 13616:LOC100011118
uniprot id: F6PXT9
names: Similarity
messages: Belongs to the TTC39 family.

13616:LOC100014881
gene id: 13616:LOC100014881
uniprot id: F7C1X6
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:TENM2
gene id: 13616:TENM2
uniprot id: A0A5F8GJU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ADI1
gene id: 13616:ADI1
uniprot id: F7FKV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

13616:CHRM2
gene id: 13616:CHRM2
uniprot id: F7DJJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

13616:ST3GAL5
gene id: 13616:ST3GAL5
uniprot id: A0A5F8GW05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:LOC100012635
gene id: 13616:LOC100012635
uniprot id: F6WA61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

13616:RHBDD1
gene id: 13616:RHBDD1
uniprot id: A0A5F8GW25
names: Subcellular Location Annotation
messages: Membrane

13616:PSAT1
gene id: 13616:PSAT1
uniprot id: F7DC74
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

13616:ABCC2
gene id: 13616:ABCC2
uniprot id: F6Z127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

13616:PIAS4
gene id: 13616:PIAS4
uniprot id: F6SSV5
names: Similarity
messages: Belongs to the PIAS family.

13616:CRIPT
gene id: 13616:CRIPT
uniprot id: F7ESU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

13616:RPL14
gene id: 13616:RPL14
uniprot id: F6U375
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

13616:TMEM138
gene id: 13616:TMEM138
uniprot id: A0A5F8HAA5
uniprot id: A0A5F8HJB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

13616:RPS27A
gene id: 13616:RPS27A
uniprot id: F6T5K6
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

13616:SNX11
gene id: 13616:SNX11
uniprot id: A0A5F8HJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

13616:MEA1
gene id: 13616:MEA1
uniprot id: F7CP91
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

13616:TFR2
gene id: 13616:TFR2
uniprot id: F6R440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

13616:SPTLC2
gene id: 13616:SPTLC2
uniprot id: F7E6T2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

13616:GRIK4
gene id: 13616:GRIK4
uniprot id: F7FB74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:PLXNC1
gene id: 13616:PLXNC1
uniprot id: F7C5U5
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CTSZ
gene id: 13616:CTSZ
uniprot id: F6ZD89
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:RIBC2
gene id: 13616:RIBC2
uniprot id: F7FQY6
names: Similarity
messages: Belongs to the RIB43A family.

13616:LECT1
gene id: 13616:LECT1
uniprot id: F6YNA3
names: Similarity
messages: Belongs to the chondromodulin-1 family.

13616:KCND2
gene id: 13616:KCND2
uniprot id: F7F5R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

13616:METTL6
gene id: 13616:METTL6
uniprot id: F7E9G8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

13616:monDomV1R1203
gene id: 13616:monDomV1R1203
uniprot id: A0A5F8HBQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMEM192
gene id: 13616:TMEM192
uniprot id: F7CWE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

13616:LOC100016492
gene id: 13616:LOC100016492
uniprot id: A0A5F8GQZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CRAT
gene id: 13616:CRAT
uniprot id: A0A5F8H5F9
uniprot id: F7DGV8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:CLDN9
gene id: 13616:CLDN9
uniprot id: F6ZDG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:KEG11 p11
gene id: 13616:KEG11_p11
uniprot id: Q65CJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ZEB2
gene id: 13616:ZEB2
uniprot id: A0A5F8H9X6
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

13616:INIP
gene id: 13616:INIP
uniprot id: F6U5A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

13616:FBXO46
gene id: 13616:FBXO46
uniprot id: K7E0C4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

13616:STARD13
gene id: 13616:STARD13
uniprot id: F6YBE5
names: Subcellular Location Annotation
messages: Cytoplasm

13616:SNW1
gene id: 13616:SNW1
uniprot id: F7GGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

13616:EGR1
gene id: 13616:EGR1
uniprot id: A0A5F8HGN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

13616:BOK
gene id: 13616:BOK
uniprot id: F7G9S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

13616:YPEL4
gene id: 13616:YPEL4
uniprot id: F7ERY8
names: Similarity
messages: Belongs to the yippee family.

13616:NPTX2
gene id: 13616:NPTX2
uniprot id: F7BVD5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RPS16
gene id: 13616:RPS16
uniprot id: F7C3L8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

13616:LOC100025644
gene id: 13616:LOC100025644
uniprot id: A0A5F8HG58
names: Similarity
messages: Belongs to the 2-5A synthase family.

13616:SLC2A9
gene id: 13616:SLC2A9
uniprot id: A0A5F8G2I1
uniprot id: A0A5F8GSW3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:CYP1A1
gene id: 13616:CYP1A1
uniprot id: F7DFG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:monDomV1R1245
gene id: 13616:monDomV1R1245
uniprot id: A0A5F8HDU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MFSD7
gene id: 13616:MFSD7
uniprot id: F6XEJ5
names: Subcellular Location Annotation
messages: Membrane

13616:MAP2K2
gene id: 13616:MAP2K2
uniprot id: F6S9S9
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:ZUFSP
gene id: 13616:ZUFSP
uniprot id: A0A5F8G7K3
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

13616:SNTG1
gene id: 13616:SNTG1
uniprot id: A0A5F8G4F3
uniprot id: A0A5F8G9Z1
uniprot id: F6UUW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

13616:DYRK4
gene id: 13616:DYRK4
uniprot id: F6PWQ2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

13616:CNTF
gene id: 13616:CNTF
uniprot id: A0A5F8HE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

13616:SEBOX
gene id: 13616:SEBOX
uniprot id: A0A5F8HEM7
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100024173
gene id: 13616:LOC100024173
uniprot id: F7EI14
names: Subcellular Location Annotation
messages: Membrane

13616:NIPSNAP1
gene id: 13616:NIPSNAP1
uniprot id: A0A5F8GTP3
names: Similarity
messages: Belongs to the NipSnap family.

13616:MFSD6
gene id: 13616:MFSD6
uniprot id: A0A5F8G7J5
uniprot id: A0A5F8HC90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

13616:IL1RN
gene id: 13616:IL1RN
uniprot id: F6TEW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

13616:MAFB
gene id: 13616:MAFB
uniprot id: A0A5F8G788
uniprot id: F6XN23
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

13616:OPRK1
gene id: 13616:OPRK1
uniprot id: F7F9H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with SLC9A3R1. Interacts with GABARAPL1.
messages: Membrane

13616:VPS37A
gene id: 13616:VPS37A
uniprot id: F7AXY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

13616:ACMSD
gene id: 13616:ACMSD
uniprot id: A0A5F8GYS8
uniprot id: F6SFT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

13616:LOC100020096
gene id: 13616:LOC100020096
uniprot id: F7BM51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

13616:LOC100618560
gene id: 13616:LOC100618560
uniprot id: A0A5F8GXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100020786
gene id: 13616:LOC100020786
uniprot id: F6PZ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TSC22D2
gene id: 13616:TSC22D2
uniprot id: A0A5F8GSA9
uniprot id: F6T2U7
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

13616:TRAPPC11
gene id: 13616:TRAPPC11
uniprot id: F6SXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

13616:FGF7
gene id: 13616:FGF7
uniprot id: A0A5F8HJ88
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:IFI6
gene id: 13616:IFI6
uniprot id: F7CKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

13616:RFC1
gene id: 13616:RFC1
uniprot id: F7BBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

13616:NDFIP2
gene id: 13616:NDFIP2
uniprot id: F6QMS0
names: Subcellular Location Annotation
messages: Membrane

13616:DUSP1
gene id: 13616:DUSP1
uniprot id: A0A5F8H9X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

13616:NHSL2
gene id: 13616:NHSL2
uniprot id: A0A5F8GD61
uniprot id: A0A5F8GWA6
uniprot id: A0A5F8GWX4
uniprot id: F6PJQ8
names: Similarity
messages: Belongs to the NHS family.

13616:SLC31A1
gene id: 13616:SLC31A1
uniprot id: A0A5F8G741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

13616:LOC100018393
gene id: 13616:LOC100018393
uniprot id: F6VEU5
names: Subcellular Location Annotation
messages: Membrane

13616:MODO-UB
gene id: 13616:MODO-UB
uniprot id: Q5W5U6
names: Similarity
messages: Belongs to the MHC class I family.

13616:LOC100028068
gene id: 13616:LOC100028068
uniprot id: F7G826
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TFAP2D
gene id: 13616:TFAP2D
uniprot id: F7GKB3
names: Similarity
messages: Belongs to the AP-2 family.

13616:LOC100031405
gene id: 13616:LOC100031405
uniprot id: F6YI65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

13616:MLST8
gene id: 13616:MLST8
uniprot id: F6ZQS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

13616:MTFR1
gene id: 13616:MTFR1
uniprot id: A0A5F8H0T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

13616:PKLR
gene id: 13616:PKLR
uniprot id: F6XZC6
uniprot id: K7E2Q6
names: Similarity
messages: Belongs to the pyruvate kinase family.

13616:FMNL2
gene id: 13616:FMNL2
uniprot id: A0A5F8GTE0
uniprot id: F6UDT7
names: Similarity
messages: Belongs to the formin homology family.

13616:MRPS6
gene id: 13616:MRPS6
uniprot id: F6VJJ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

13616:MMP9
gene id: 13616:MMP9
uniprot id: F6X875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

13616:PGAM2
gene id: 13616:PGAM2
uniprot id: A0A5F8GU47
uniprot id: F6VBM7
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

13616:SLC25A44
gene id: 13616:SLC25A44
uniprot id: F6VN60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:BUD13
gene id: 13616:BUD13
uniprot id: A0A5F8GCJ7
uniprot id: F6ZX29
names: Similarity
messages: Belongs to the CWC26 family.

13616:CA12
gene id: 13616:CA12
uniprot id: A0A5F8G655
uniprot id: A0A5F8GDB5
uniprot id: F7F4C7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:GABARAP
gene id: 13616:GABARAP
uniprot id: A0A5F8GH28
names: Similarity
messages: Belongs to the ATG8 family.

13616:SLC6A13
gene id: 13616:SLC6A13
uniprot id: A0A5F8GDU4
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

13616:CDH6
gene id: 13616:CDH6
uniprot id: F6Y191
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:monDomV1R1260
gene id: 13616:monDomV1R1260
uniprot id: F6V7F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GAPVD1
gene id: 13616:GAPVD1
uniprot id: A0A5F8G2S5
uniprot id: A0A5F8GC18
uniprot id: F6W7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

13616:CLDN18
gene id: 13616:CLDN18
uniprot id: F7GCU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:ITGA8
gene id: 13616:ITGA8
uniprot id: F6TCV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:KPNA1
gene id: 13616:KPNA1
uniprot id: F6PVH5
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:ADGB
gene id: 13616:ADGB
uniprot id: A0A5F8G1N3
uniprot id: A0A5F8G9G5
uniprot id: F6RUJ9
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PCNX2
gene id: 13616:PCNX2
uniprot id: F7CC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

13616:FAM69A
gene id: 13616:FAM69A
uniprot id: F6U180
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

13616:PSME1
gene id: 13616:PSME1
uniprot id: F7GBS5
names: Similarity
messages: Belongs to the PA28 family.

13616:GSK3B
gene id: 13616:GSK3B
uniprot id: A0A5F8GBH0
uniprot id: A0A5F8HIG1
uniprot id: F6PGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

13616:MYO1B
gene id: 13616:MYO1B
uniprot id: A0A5F8G3G8
uniprot id: A0A5F8GY12
uniprot id: A0A5F8HAT0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:VN2R556
gene id: 13616:VN2R556
uniprot id: F6T901
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:monDomV1R1283
gene id: 13616:monDomV1R1283
uniprot id: F7GES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SSBP1
gene id: 13616:SSBP1
uniprot id: A0A5F8GSL6
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

13616:POLR3C
gene id: 13616:POLR3C
uniprot id: F7EF59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

13616:LOC100013294
gene id: 13616:LOC100013294
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:KIAA1024
gene id: 13616:KIAA1024
uniprot id: A0A5F8GTD6
uniprot id: A0A5F8H4P0
names: Similarity
messages: Belongs to the MINAR family.

13616:TSHZ3
gene id: 13616:TSHZ3
uniprot id: F6PNB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

13616:ST8SIA1
gene id: 13616:ST8SIA1
uniprot id: F7ELG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:TMEM38A
gene id: 13616:TMEM38A
uniprot id: F7FI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

13616:NFIL3
gene id: 13616:NFIL3
uniprot id: F6VLC7
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

13616:CENPO
gene id: 13616:CENPO
uniprot id: F7AGM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

13616:ADCY3
gene id: 13616:ADCY3
uniprot id: F7B3B0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:FAP
gene id: 13616:FAP
uniprot id: F7DK16
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: invadopodium membrane
messages: lamellipodium membrane

13616:GNA12
gene id: 13616:GNA12
uniprot id: F6TFQ0
uniprot id: K7E5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

13616:TMEM107
gene id: 13616:TMEM107
uniprot id: A0A5F8GZ81
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100024194
gene id: 13616:LOC100024194
uniprot id: F7A1K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:AKR1B1
gene id: 13616:AKR1B1
uniprot id: K7E1G6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

13616:SLC9A9
gene id: 13616:SLC9A9
uniprot id: F6TJF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

13616:ZFX
gene id: 13616:ZFX
uniprot id: F7GJX3
names: Subcellular Location Annotation
messages: Nucleus

13616:ANKH
gene id: 13616:ANKH
uniprot id: F6Q5B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

13616:PLXNB3
gene id: 13616:PLXNB3
uniprot id: F6PJL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100012041
gene id: 13616:LOC100012041
uniprot id: F6SSZ9
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

13616:LOC100018508
gene id: 13616:LOC100018508
uniprot id: A0A5F8HB60
uniprot id: F7GHL5
names: Similarity
messages: Belongs to the NLRP family.

13616:DPCD
gene id: 13616:DPCD
uniprot id: F7DFJ0
names: Similarity
messages: Belongs to the DPCD family.

13616:ART5
gene id: 13616:ART5
uniprot id: F7A3I9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

13616:DCTN1
gene id: 13616:DCTN1
uniprot id: A0A5F8GV11
uniprot id: F7EQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

13616:DLAT
gene id: 13616:DLAT
uniprot id: A0A5F8G712
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

13616:FAM160B2
gene id: 13616:FAM160B2
uniprot id: F6QTD9
uniprot id: F7DSY2
names: Similarity
messages: Belongs to the FHIP family.

13616:GRHPR
gene id: 13616:GRHPR
uniprot id: A0A5F8GK27
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

13616:SLC22A1
gene id: 13616:SLC22A1
uniprot id: F6PRJ7
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

13616:KLRK1
gene id: 13616:KLRK1
uniprot id: A0A5F8HKU4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:AGPAT2
gene id: 13616:AGPAT2
uniprot id: F7AHW4
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

13616:HS2ST1
gene id: 13616:HS2ST1
uniprot id: F7ELC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

13616:MED14
gene id: 13616:MED14
uniprot id: F6UIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

13616:YOD1
gene id: 13616:YOD1
uniprot id: F6YEW2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

13616:MFAP3
gene id: 13616:MFAP3
uniprot id: A0A5F8GTC1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100618720
gene id: 13616:LOC100618720
uniprot id: F6Q2K6
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100032873
gene id: 13616:LOC100032873
uniprot id: F7EXL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
messages: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.
messages: Secreted

13616:LOC100031219
gene id: 13616:LOC100031219
uniprot id: F6RSG9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:ACTR3B
gene id: 13616:ACTR3B
uniprot id: F6TPU3
names: Similarity
messages: Belongs to the actin family.

13616:PPIL3
gene id: 13616:PPIL3
uniprot id: F7BX89
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:TNFRSF11A
gene id: 13616:TNFRSF11A
uniprot id: F7AS58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RRAGD
gene id: 13616:RRAGD
uniprot id: F6Q6M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

13616:LOC100020624
gene id: 13616:LOC100020624
uniprot id: F7API2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EXOC1
gene id: 13616:EXOC1
uniprot id: A0A5F8GAA7
uniprot id: A0A5F8GDX2
uniprot id: A0A5F8GLJ5
uniprot id: F7DKR4
names: Similarity
messages: Belongs to the SEC3 family.

13616:LOC100020685
gene id: 13616:LOC100020685
uniprot id: F7A114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PEX7
gene id: 13616:PEX7
uniprot id: F6ZV69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

13616:THBS1
gene id: 13616:THBS1
uniprot id: F6WMA0
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CDC42SE2
gene id: 13616:CDC42SE2
uniprot id: F6ZHW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

13616:EYA3
gene id: 13616:EYA3
uniprot id: A0A5F8H8J1
uniprot id: A0A5F8HET8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

13616:KIAA1715
gene id: 13616:KIAA1715
uniprot id: A0A5F8H9H1
uniprot id: K7E0B9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

13616:SLC2A2
gene id: 13616:SLC2A2
uniprot id: F6ZHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

13616:STK4
gene id: 13616:STK4
uniprot id: A0A5F8HFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

13616:PDCD5
gene id: 13616:PDCD5
uniprot id: F7E2R5
names: Similarity
messages: Belongs to the PDCD5 family.

13616:LOC100019992
gene id: 13616:LOC100019992
uniprot id: A0A5F8HAC6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

13616:B9D1
gene id: 13616:B9D1
uniprot id: K7E5P2
names: Subcellular Location Annotation
messages: cilium basal body

13616:SRPX2
gene id: 13616:SRPX2
uniprot id: F7GLN8
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

13616:DPAGT1
gene id: 13616:DPAGT1
uniprot id: F7A9Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC103094764
gene id: 13616:LOC103094764
uniprot id: F6SFK7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

13616:LOC100011915
gene id: 13616:LOC100011915
uniprot id: F6ZBI1
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100012174
gene id: 13616:LOC100012174
uniprot id: F7CHH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

13616:JAG2
gene id: 13616:JAG2
uniprot id: A0A5F8GH40
uniprot id: F7D3A1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

13616:ENPP1
gene id: 13616:ENPP1
uniprot id: F7BSJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

13616:LOC100011600
gene id: 13616:LOC100011600
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:LOC100028192
gene id: 13616:LOC100028192
uniprot id: A0A5F8GAA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CPNE9
gene id: 13616:CPNE9
uniprot id: F7EIB0
names: Similarity
messages: Belongs to the copine family.

13616:POLR3B
gene id: 13616:POLR3B
uniprot id: F6WGH7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

13616:OPRL1
gene id: 13616:OPRL1
uniprot id: F6XHC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

13616:LOC100027021
gene id: 13616:LOC100027021
uniprot id: A0A5F8H5J0
uniprot id: F7AFX2
names: Similarity
messages: Belongs to the COX20 family.

13616:LOC100619212
gene id: 13616:LOC100619212
uniprot id: F6ZIN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DLX2
gene id: 13616:DLX2
uniprot id: F7B4F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

13616:MED20
gene id: 13616:MED20
uniprot id: A0A5F8GVL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

13616:RC3H1
gene id: 13616:RC3H1
uniprot id: F6SY20
names: Subcellular Location Annotation
messages: P-body

13616:TGFB2
gene id: 13616:TGFB2
uniprot id: F6XNK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

13616:LOC100021845
gene id: 13616:LOC100021845
uniprot id: F7BRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CACNG4
gene id: 13616:CACNG4
uniprot id: A0A5F8GP97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

13616:VN2R606
gene id: 13616:VN2R606
uniprot id: A0A5F8GGY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SUDS3
gene id: 13616:SUDS3
uniprot id: F6XZ37
names: Subcellular Location Annotation
messages: Nucleus

13616:UBL4A
gene id: 13616:UBL4A
uniprot id: F7BQ80
names: Subcellular Location Annotation
messages: cytosol

13616:SLCO1A2
gene id: 13616:SLCO1A2
uniprot id: F6ZXK1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:HABP2
gene id: 13616:HABP2
uniprot id: F6XM86
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:SARDH
gene id: 13616:SARDH
uniprot id: F7GBN5
names: Similarity
messages: Belongs to the GcvT family.

13616:LOC100022736
gene id: 13616:LOC100022736
uniprot id: F7CAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ITGA2
gene id: 13616:ITGA2
uniprot id: F6RXC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:LOC103093665
gene id: 13616:LOC103093665
uniprot id: F7BK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:DAD1
gene id: 13616:DAD1
uniprot id: F7CZ61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

13616:GFOD1
gene id: 13616:GFOD1
uniprot id: F7DP86
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

13616:MAPK13
gene id: 13616:MAPK13
uniprot id: F6TXC2
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

13616:LOC100619854
gene id: 13616:LOC100619854
uniprot id: F6SNL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MIS12
gene id: 13616:MIS12
uniprot id: F7GGZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

13616:DENND5A
gene id: 13616:DENND5A
uniprot id: A0A5F8G9V0
uniprot id: F7A8J4
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DCLRE1B
gene id: 13616:DCLRE1B
uniprot id: F6X212
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

13616:CDS2
gene id: 13616:CDS2
uniprot id: A0A5F8HGY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

13616:DCPS
gene id: 13616:DCPS
uniprot id: F6Y3D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

13616:C4BPB
gene id: 13616:C4BPB
uniprot id: F7G3E0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:THNSL1
gene id: 13616:THNSL1
uniprot id: F6WJR7
names: Similarity
messages: Belongs to the threonine synthase family.

13616:CDH11
gene id: 13616:CDH11
uniprot id: F6XVG8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:ADGRF2
gene id: 13616:ADGRF2
uniprot id: F7DVG9
names: Subcellular Location Annotation
messages: Membrane

13616:STON2
gene id: 13616:STON2
uniprot id: A0A5F8H276
uniprot id: F7EW99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

13616:PPIA
gene id: 13616:PPIA
uniprot id: F7FZ45
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:INPP5K
gene id: 13616:INPP5K
uniprot id: A0A5F8HKR9
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

13616:LOC100013132
gene id: 13616:LOC100013132
uniprot id: F6Z964
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

13616:FH
gene id: 13616:FH
uniprot id: F6XCG4
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

13616:LRWD1
gene id: 13616:LRWD1
uniprot id: F6VF30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

13616:ROR2
gene id: 13616:ROR2
uniprot id: F6RDI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:METTL10
gene id: 13616:METTL10
uniprot id: F6SAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

13616:SERPINE1
gene id: 13616:SERPINE1
uniprot id: F7C1N5
names: Similarity
messages: Belongs to the serpin family.

13616:LOC100023529
gene id: 13616:LOC100023529
uniprot id: F7F434
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC103106484
gene id: 13616:LOC103106484
uniprot id: A0A5F8GAI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

13616:DIMT1
gene id: 13616:DIMT1
uniprot id: A0A5F8H757
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

13616:AP3M2
gene id: 13616:AP3M2
uniprot id: A0A5F8G829
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

13616:MME
gene id: 13616:MME
uniprot id: F7FEB8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

13616:TRH
gene id: 13616:TRH
uniprot id: K7E2N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

13616:LOC100017854
gene id: 13616:LOC100017854
uniprot id: F6YZV6
names: Similarity
messages: Belongs to the actin family.

13616:GLI2
gene id: 13616:GLI2
uniprot id: A0A5F8GAN0
uniprot id: F6RAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

13616:USP22
gene id: 13616:USP22
uniprot id: A0A5F8HEI4
uniprot id: F7BCG1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:TINAGL1
gene id: 13616:TINAGL1
uniprot id: K7E479
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:KCNE3
gene id: 13616:KCNE3
uniprot id: F6WTC2
names: Similarity
messages: Belongs to the potassium channel KCNE family.

13616:TMEM35
gene id: 13616:TMEM35
uniprot id: F7DFA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

13616:PARP2
gene id: 13616:PARP2
uniprot id: F6RCB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

13616:COQ4
gene id: 13616:COQ4
uniprot id: F6WFU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

13616:FAM174B
gene id: 13616:FAM174B
uniprot id: F6ZLM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

13616:TRIM9
gene id: 13616:TRIM9
uniprot id: F7C2Z3
names: Subcellular Location Annotation
messages: cytoskeleton

13616:EIF1AX
gene id: 13616:EIF1AX
uniprot id: K7E1Z1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

13616:TRUB2
gene id: 13616:TRUB2
uniprot id: F6WW62
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

13616:IRF2
gene id: 13616:IRF2
uniprot id: F6SVQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:NADK
gene id: 13616:NADK
uniprot id: A0A5F8GV69
names: Similarity
messages: Belongs to the NAD kinase family.

13616:LOC100017995
gene id: 13616:LOC100017995
uniprot id: A0A5F8GE62
names: Subcellular Location Annotation
messages: nucleoplasm

13616:ICAM2
gene id: 13616:ICAM2
uniprot id: F7G0C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

13616:GPR155
gene id: 13616:GPR155
uniprot id: F7G012
names: Subcellular Location Annotation
messages: Membrane

13616:monDomV1R1219
gene id: 13616:monDomV1R1219
uniprot id: A0A5F8G8C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:USP37
gene id: 13616:USP37
uniprot id: F6SMT5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:KLHL40
gene id: 13616:KLHL40
uniprot id: F7AVX2
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

13616:LOC100020188
gene id: 13616:LOC100020188
uniprot id: F7ED75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:MB21D1
gene id: 13616:MB21D1
uniprot id: F7GD20
names: Similarity
messages: Belongs to the mab-21 family.

13616:DYRK1A
gene id: 13616:DYRK1A
uniprot id: A0A5F8G6H1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

13616:LOC100024870
gene id: 13616:LOC100024870
uniprot id: F6VY06
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MTURN
gene id: 13616:MTURN
uniprot id: F6T6L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

13616:PBX4
gene id: 13616:PBX4
uniprot id: A0A5F8HE59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

13616:CREB3L2
gene id: 13616:CREB3L2
uniprot id: F6W973
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:LOC103099606
gene id: 13616:LOC103099606
uniprot id: F7F990
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:EIF2D
gene id: 13616:EIF2D
uniprot id: F6UZY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

13616:LOC100020762
gene id: 13616:LOC100020762
uniprot id: F7EM99
names: Subcellular Location Annotation
messages: Membrane

13616:PPT2
gene id: 13616:PPT2
uniprot id: A0A5F8GWX6
uniprot id: F7G659
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

13616:LOC100027961
gene id: 13616:LOC100027961
uniprot id: F6PSC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

13616:LOC107651035
gene id: 13616:LOC107651035
uniprot id: A0A5F8HFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DPH3
gene id: 13616:DPH3
uniprot id: F6RJE2
names: Similarity
messages: Belongs to the DPH3 family.

13616:EPB41L5
gene id: 13616:EPB41L5
uniprot id: A0A5F8HAY6
uniprot id: K7E3J9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

13616:PLCG1
gene id: 13616:PLCG1
uniprot id: F6TAH0
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

13616:COPS2
gene id: 13616:COPS2
uniprot id: F7DDQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

13616:FBLN5
gene id: 13616:FBLN5
uniprot id: A0A5F8HBK9
uniprot id: A0A5F8HCL1
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:BHMT2
gene id: 13616:BHMT2
uniprot id: A0A5F8G3W4
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

13616:SNX1
gene id: 13616:SNX1
uniprot id: F7FIU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

13616:BTG4
gene id: 13616:BTG4
uniprot id: F7FKK2
names: Similarity
messages: Belongs to the BTG family.

13616:SKA1
gene id: 13616:SKA1
uniprot id: F6ZJ97
names: Similarity
messages: Belongs to the SKA1 family.

13616:DSC1
gene id: 13616:DSC1
uniprot id: A0A5F8GL62
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

13616:MALL
gene id: 13616:MALL
uniprot id: F6WSL8
names: Subcellular Location Annotation
messages: Membrane

13616:PLAC8
gene id: 13616:PLAC8
uniprot id: F6RYA5
names: Similarity
messages: Belongs to the cornifelin family.

13616:VN2R640
gene id: 13616:VN2R640
uniprot id: A0A5F8GXZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100016683
gene id: 13616:LOC100016683
uniprot id: F6WJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

13616:NOTCH2
gene id: 13616:NOTCH2
uniprot id: F7AVD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

13616:FGA
gene id: 13616:FGA
uniprot id: F7CJ60
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

13616:AMER3
gene id: 13616:AMER3
uniprot id: F7B2Z7
names: Similarity
messages: Belongs to the Amer family.

13616:HSFX
gene id: 13616:HSFX
uniprot id: A0A5F8G686
uniprot id: A0A5F8G6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

13616:MBOAT1
gene id: 13616:MBOAT1
uniprot id: F6WIK0
names: Subcellular Location Annotation
messages: Membrane

13616:PCBD2
gene id: 13616:PCBD2
uniprot id: A0A5F8GNM8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

13616:RNF152
gene id: 13616:RNF152
uniprot id: F7BN35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

13616:SUSD5
gene id: 13616:SUSD5
uniprot id: A0A5F8HEV7
uniprot id: F6QZI7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100015172
gene id: 13616:LOC100015172
uniprot id: F6VI36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

13616:LOC100031248
gene id: 13616:LOC100031248
uniprot id: F7EI61
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TTC4
gene id: 13616:TTC4
uniprot id: F7D8P9
names: Similarity
messages: Belongs to the TTC4 family.

13616:POLR1B
gene id: 13616:POLR1B
uniprot id: F7B818
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

13616:PAX9
gene id: 13616:PAX9
uniprot id: F6VG93
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

13616:NTMT1
gene id: 13616:NTMT1
uniprot id: F7CCN4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

13616:MAN2A2
gene id: 13616:MAN2A2
uniprot id: F6RWB3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

13616:GPR65
gene id: 13616:GPR65
uniprot id: F6YMU4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:SLC35A1
gene id: 13616:SLC35A1
uniprot id: F6PUN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

13616:FAH
gene id: 13616:FAH
uniprot id: A0A5F8GBC8
names: Similarity
messages: Belongs to the FAH family.

13616:RENBP
gene id: 13616:RENBP
uniprot id: F6QCF6
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

13616:WARS
gene id: 13616:WARS
uniprot id: F7ACJ5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:NASP
gene id: 13616:NASP
uniprot id: F7CC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

13616:MED6
gene id: 13616:MED6
uniprot id: F6RC94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

13616:FUT7
gene id: 13616:FUT7
uniprot id: F6T3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

13616:LOC103102395
gene id: 13616:LOC103102395
uniprot id: A0A5F8GTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

13616:DNAH7
gene id: 13616:DNAH7
uniprot id: F7FU84
names: Similarity
messages: Belongs to the dynein heavy chain family.

13616:LOC100017655
gene id: 13616:LOC100017655
uniprot id: F6U3G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

13616:ADPRHL1
gene id: 13616:ADPRHL1
uniprot id: F7EBM0
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

13616:NDUFA2
gene id: 13616:NDUFA2
uniprot id: F6W1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:LOC100029158
gene id: 13616:LOC100029158
uniprot id: F7EH45
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:EEF2K
gene id: 13616:EEF2K
uniprot id: A0A5F8GW10
uniprot id: F7C485
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

13616:QPRT
gene id: 13616:QPRT
uniprot id: F7AQ58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

13616:MAP2K1
gene id: 13616:MAP2K1
uniprot id: F6XT65
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:YRDC
gene id: 13616:YRDC
uniprot id: F7E541
names: Similarity
messages: Belongs to the SUA5 family.

13616:LGI2
gene id: 13616:LGI2
uniprot id: F6US32
names: Subcellular Location Annotation
messages: Secreted

13616:RAP1GDS1
gene id: 13616:RAP1GDS1
uniprot id: A0A5F8G5W2
uniprot id: F7BAB1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: cytosol

13616:LOC103105104
gene id: 13616:LOC103105104
uniprot id: F6RJI9
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

13616:LOC100031136
gene id: 13616:LOC100031136
uniprot id: A0A5F8H3A3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:EXOC2
gene id: 13616:EXOC2
uniprot id: A0A5F8HJA1
uniprot id: F7CDZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

13616:HSPA13
gene id: 13616:HSPA13
uniprot id: F6SPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

13616:LOC100020170
gene id: 13616:LOC100020170
uniprot id: A0A5F8H0Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VN2R591
gene id: 13616:VN2R591
uniprot id: A0A5F8GRN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:FAM150B
gene id: 13616:FAM150B
uniprot id: F6XIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

13616:MAP2K5
gene id: 13616:MAP2K5
uniprot id: A0A5F8G226
uniprot id: A0A5F8H919
uniprot id: F7C4E9
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:SLC44A1
gene id: 13616:SLC44A1
uniprot id: F7BGP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

13616:SUFU
gene id: 13616:SUFU
uniprot id: F6RMT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

13616:SPATS2
gene id: 13616:SPATS2
uniprot id: F6XQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

13616:PPP4R2
gene id: 13616:PPP4R2
uniprot id: F7G9R3
names: Similarity
messages: Belongs to the PPP4R2 family.

13616:MMP17
gene id: 13616:MMP17
uniprot id: F7AIM3
names: Similarity
messages: Belongs to the peptidase M10A family.

13616:PRKACB
gene id: 13616:PRKACB
uniprot id: A0A5F8GT51
uniprot id: F6XMR1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

13616:SIVA1
gene id: 13616:SIVA1
uniprot id: F6TX86
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

13616:LOC100617936
gene id: 13616:LOC100617936
uniprot id: A0A5F8GBB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:ALAS2
gene id: 13616:ALAS2
uniprot id: F7G8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

13616:DYNC1LI1
gene id: 13616:DYNC1LI1
uniprot id: F6V4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

13616:SH3BP5
gene id: 13616:SH3BP5
uniprot id: F7ER25
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

13616:SOX8
gene id: 13616:SOX8
uniprot id: F6XIA1
names: Subcellular Location Annotation
messages: Nucleus

13616:ST7
gene id: 13616:ST7
uniprot id: A0A5F8GIW5
uniprot id: A0A5F8GL78
uniprot id: F7FRY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

13616:STK35L3
gene id: 13616:STK35L3
uniprot id: F6PGF5
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100021916
gene id: 13616:LOC100021916
uniprot id: A0A5F8GHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TUBE1
gene id: 13616:TUBE1
uniprot id: A0A5F8G7Z7
uniprot id: F7GFL8
names: Similarity
messages: Belongs to the tubulin family.

13616:MCM9
gene id: 13616:MCM9
uniprot id: F7CZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

13616:NRP1
gene id: 13616:NRP1
uniprot id: F7DVT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:AGXT2
gene id: 13616:AGXT2
uniprot id: F7F6D0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

13616:FIGNL1
gene id: 13616:FIGNL1
uniprot id: F6U499
names: Similarity
messages: Belongs to the AAA ATPase family.

13616:LOC100016733
gene id: 13616:LOC100016733
uniprot id: A0A5F8GK04
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:RPGRIP1L
gene id: 13616:RPGRIP1L
uniprot id: A0A5F8H3D1
names: Similarity
messages: Belongs to the RPGRIP1 family.

13616:NMU
gene id: 13616:NMU
uniprot id: F6V218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

13616:IZUMO1R
gene id: 13616:IZUMO1R
uniprot id: F7AHC3
names: Similarity
messages: Belongs to the folate receptor family.

13616:DLC1
gene id: 13616:DLC1
uniprot id: F7FZ87
uniprot id: F7FZ90
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

13616:LOC100013123
gene id: 13616:LOC100013123
uniprot id: A0A5F8G8L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TIE1
gene id: 13616:TIE1
uniprot id: F6SPK9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:MOGAT1
gene id: 13616:MOGAT1
uniprot id: F6XVS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:EFHC1
gene id: 13616:EFHC1
uniprot id: F6YYR9
names: Subcellular Location Annotation
messages: cilium axoneme

13616:USP44
gene id: 13616:USP44
uniprot id: F7ELW8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:LOC100018685
gene id: 13616:LOC100018685
uniprot id: F6QC34
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:GRM4
gene id: 13616:GRM4
uniprot id: A0A5F8GR20
uniprot id: F6R6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

13616:MVD
gene id: 13616:MVD
uniprot id: F6Y9W8
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

13616:GPC2
gene id: 13616:GPC2
uniprot id: F6SV42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

13616:LOC100030117
gene id: 13616:LOC100030117
uniprot id: A0A5F8G9C1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

13616:AGPAT3
gene id: 13616:AGPAT3
uniprot id: F6W0F9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:USP15
gene id: 13616:USP15
uniprot id: F6WKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

13616:BBS10
gene id: 13616:BBS10
uniprot id: F7FJJ6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

13616:CWF19L1
gene id: 13616:CWF19L1
uniprot id: F6YQP7
names: Similarity
messages: Belongs to the CWF19 family.

13616:HSD17B1
gene id: 13616:HSD17B1
uniprot id: F7G656
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

13616:LOC100023565
gene id: 13616:LOC100023565
uniprot id: F7EC75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

13616:PRKAA1
gene id: 13616:PRKAA1
uniprot id: F7BFG2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

13616:VN2R652
gene id: 13616:VN2R652
uniprot id: A0A5F8G297
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:STX4
gene id: 13616:STX4
uniprot id: F6WIC9
names: Similarity
messages: Belongs to the syntaxin family.

13616:LIMK1
gene id: 13616:LIMK1
uniprot id: F6X673
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

13616:LOC100016791
gene id: 13616:LOC100016791
uniprot id: A0A5F8H5E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NSUN3
gene id: 13616:NSUN3
uniprot id: F6U5C4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

13616:MCTP1
gene id: 13616:MCTP1
uniprot id: A0A5F8GL23
uniprot id: A0A5F8H5K8
uniprot id: A0A5F8H8W6
uniprot id: F7DQX5
names: Subcellular Location Annotation
messages: Membrane

13616:SS18L1
gene id: 13616:SS18L1
uniprot id: F7DLT2
names: Similarity
messages: Belongs to the SS18 family.

13616:LOC100026632
gene id: 13616:LOC100026632
uniprot id: F7AJ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

13616:OPA3
gene id: 13616:OPA3
uniprot id: F7DZP8
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

13616:CADM1
gene id: 13616:CADM1
uniprot id: A0A5F8G7W2
uniprot id: A0A5F8GK08
uniprot id: A0A5F8HCB9
uniprot id: A0A5F8HE77
uniprot id: A0A5F8HFD4
uniprot id: F6W9D2
names: Similarity
messages: Belongs to the nectin family.

13616:TAT
gene id: 13616:TAT
uniprot id: F7CW54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

13616:SF3B4
gene id: 13616:SF3B4
uniprot id: F7DXP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

13616:NPC1
gene id: 13616:NPC1
uniprot id: F7G2R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

13616:ENTPD5
gene id: 13616:ENTPD5
uniprot id: F7BUY1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:DTD2
gene id: 13616:DTD2
uniprot id: A0A5F8GMX9
names: Similarity
messages: Belongs to the DTD family.

13616:TM6SF2
gene id: 13616:TM6SF2
uniprot id: F6WPM0
names: Subcellular Location Annotation
messages: Membrane

13616:VPS18
gene id: 13616:VPS18
uniprot id: F6TFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

13616:C5H4orf47
gene id: 13616:C5H4orf47
uniprot id: F6XIF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

13616:EPN2
gene id: 13616:EPN2
uniprot id: A0A5F8HKM5
uniprot id: F7F5A9
names: Similarity
messages: Belongs to the epsin family.

13616:LRRC16A
gene id: 13616:LRRC16A
uniprot id: F7G2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

13616:UTS2
gene id: 13616:UTS2
uniprot id: A0A5F8GYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

13616:ERLEC1
gene id: 13616:ERLEC1
uniprot id: A0A5F8GGF0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

13616:LOC100618274
gene id: 13616:LOC100618274
uniprot id: F6PJW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DMRT1
gene id: 13616:DMRT1
uniprot id: F6Z0D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:PGLYRP1
gene id: 13616:PGLYRP1
uniprot id: F7FSD2
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

13616:ZNF532
gene id: 13616:ZNF532
uniprot id: A0A5F8G2D2
uniprot id: F7AR81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

13616:T2R3A
gene id: 13616:T2R3A
uniprot id: Q2ABA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:SYNJ1
gene id: 13616:SYNJ1
uniprot id: A0A5F8GRI3
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

13616:TGIF2
gene id: 13616:TGIF2
uniprot id: A0A5F8GEI0
uniprot id: A0A5F8HCK7
names: Subcellular Location Annotation
messages: Nucleus

13616:monDomV1R1234
gene id: 13616:monDomV1R1234
uniprot id: F7EX64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LECT2
gene id: 13616:LECT2
uniprot id: F7BWL0
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

13616:CD3E
gene id: 13616:CD3E
uniprot id: F7D784
names: Subcellular Location Annotation
messages: Membrane

13616:MTMR2
gene id: 13616:MTMR2
uniprot id: A0A5F8G3Y0
uniprot id: A0A5F8HDZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

13616:LOC100029940
gene id: 13616:LOC100029940
uniprot id: F7FSK6
names: Subcellular Location Annotation
messages: Membrane

13616:BEST4
gene id: 13616:BEST4
uniprot id: F7GF92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

13616:GTF2E2
gene id: 13616:GTF2E2
uniprot id: F7CP70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

13616:DPEP1
gene id: 13616:DPEP1
uniprot id: F7GBL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

13616:DOLPP1
gene id: 13616:DOLPP1
uniprot id: A0A5F8GI55
uniprot id: F7FFJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

13616:MAP3K11
gene id: 13616:MAP3K11
uniprot id: A0A5F8G7F6
uniprot id: F6QT87
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

13616:FOXB2
gene id: 13616:FOXB2
uniprot id: F7DZ45
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100030261
gene id: 13616:LOC100030261
uniprot id: F7CDA3
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100013399
gene id: 13616:LOC100013399
uniprot id: F7E7L5
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100616874
gene id: 13616:LOC100616874
uniprot id: F6SAV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PDE4D
gene id: 13616:PDE4D
uniprot id: A0A5F8H431
uniprot id: F6R8A4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:monDomV1R1220
gene id: 13616:monDomV1R1220
uniprot id: A0A5F8H5J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100015907
gene id: 13616:LOC100015907
uniprot id: A0A5F8HK29
uniprot id: F7CIV5
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

13616:TIMM17B
gene id: 13616:TIMM17B
uniprot id: F6XNC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

13616:AP2M1
gene id: 13616:AP2M1
uniprot id: A0A5F8H245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

13616:MALRD1
gene id: 13616:MALRD1
uniprot id: F7AYR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PLET1
gene id: 13616:PLET1
uniprot id: F6UHU8
names: Function
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.

13616:FAM234A
gene id: 13616:FAM234A
uniprot id: A0A5F8GJC5
names: Similarity
messages: Belongs to the FAM234 family.

13616:SNUPN
gene id: 13616:SNUPN
uniprot id: F7CUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

13616:TYK2
gene id: 13616:TYK2
uniprot id: F6V3I2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

13616:PPP3CA
gene id: 13616:PPP3CA
uniprot id: A0A5F8G7J7
uniprot id: F7DKU1
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

13616:MRPS18A
gene id: 13616:MRPS18A
uniprot id: F7DYS6
names: Subcellular Location Annotation
messages: Mitochondrion

13616:MED30
gene id: 13616:MED30
uniprot id: F6VFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

13616:CHUK
gene id: 13616:CHUK
uniprot id: F6YS11
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:TPPP3
gene id: 13616:TPPP3
uniprot id: F6WFW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

13616:UGCG
gene id: 13616:UGCG
uniprot id: F7FHW3
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

13616:CRMP1
gene id: 13616:CRMP1
uniprot id: F7DXA3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

13616:monDomV1R1264
gene id: 13616:monDomV1R1264
uniprot id: A0A5F8GFQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CLIC3
gene id: 13616:CLIC3
uniprot id: F6S4Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

13616:TDP2
gene id: 13616:TDP2
uniprot id: A0A5F8GEF8
uniprot id: K7E4B3
names: Subcellular Location Annotation
messages: PML body

13616:MYH7
gene id: 13616:MYH7
uniprot id: A0A5F8H8U6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:AKR1A1
gene id: 13616:AKR1A1
uniprot id: F7GDV9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

13616:VARS
gene id: 13616:VARS
uniprot id: F7B9X7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:LOC103092017
gene id: 13616:LOC103092017
uniprot id: A0A5F8GYE3
uniprot id: A0A5F8HGG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

13616:GCM1
gene id: 13616:GCM1
uniprot id: F6ZME1
names: Subcellular Location Annotation
messages: Nucleus

13616:NONO
gene id: 13616:NONO
uniprot id: F6RSW7
names: Subcellular Location Annotation
messages: Nucleus speckle

13616:DCLK1
gene id: 13616:DCLK1
uniprot id: A0A5F8GRG3
uniprot id: A0A5F8GWP9
uniprot id: F6QMV8
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

13616:PROSC
gene id: 13616:PROSC
uniprot id: F7FW91
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

13616:GBA
gene id: 13616:GBA
uniprot id: F6VKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

13616:RASSF5
gene id: 13616:RASSF5
uniprot id: F6QW39
names: Subcellular Location Annotation
messages: cytoskeleton

13616:ECHS1
gene id: 13616:ECHS1
uniprot id: F7ESK8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:LOC100028976
gene id: 13616:LOC100028976
uniprot id: F6UAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:WLS
gene id: 13616:WLS
uniprot id: F6T8H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

13616:F13B
gene id: 13616:F13B
uniprot id: F6WU37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NDUFB5
gene id: 13616:NDUFB5
uniprot id: F7G3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:ATP5C1
gene id: 13616:ATP5C1
uniprot id: A0A5F8G633
uniprot id: F7CHH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

13616:PI4K2B
gene id: 13616:PI4K2B
uniprot id: F6QMN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

13616:HSPA9
gene id: 13616:HSPA9
uniprot id: F7G4T9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:GGCX
gene id: 13616:GGCX
uniprot id: F6Z5J6
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

13616:CTSW
gene id: 13616:CTSW
uniprot id: F7EY12
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:LOC100018206
gene id: 13616:LOC100018206
uniprot id: F6V827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NANOS2
gene id: 13616:NANOS2
uniprot id: A0A5F8H579
names: Similarity
messages: Belongs to the nanos family.

13616:CYFIP2
gene id: 13616:CYFIP2
uniprot id: F6VDV5
names: Similarity
messages: Belongs to the CYFIP family.

13616:LOC100021550
gene id: 13616:LOC100021550
uniprot id: F6VIN8
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

13616:MYT1
gene id: 13616:MYT1
uniprot id: A0A5F8HC68
uniprot id: A0A5F8HCF7
uniprot id: F6VKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

13616:PHC1
gene id: 13616:PHC1
uniprot id: A0A5F8H689
names: Subcellular Location Annotation
messages: Nucleus

13616:FNIP1
gene id: 13616:FNIP1
uniprot id: A0A5F8G300
uniprot id: F6Y4V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

13616:AKT3
gene id: 13616:AKT3
uniprot id: F7GEK1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

13616:MAPK3
gene id: 13616:MAPK3
uniprot id: F7EI48
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola

13616:LOC100618014
gene id: 13616:LOC100618014
uniprot id: A0A5F8HEB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SF3B5
gene id: 13616:SF3B5
uniprot id: A0A5F8GFZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

13616:LOC100021883
gene id: 13616:LOC100021883
uniprot id: A0A5F8GZ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:STXBP2
gene id: 13616:STXBP2
uniprot id: A0A5F8H0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

13616:CEBPD
gene id: 13616:CEBPD
uniprot id: F7DQJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

13616:LOC100018739
gene id: 13616:LOC100018739
uniprot id: F6PX60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:PAQR7
gene id: 13616:PAQR7
uniprot id: F7C2X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:GDF2
gene id: 13616:GDF2
uniprot id: A0A5F8GIG5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:GCLM
gene id: 13616:GCLM
uniprot id: A0A5F8H8N6
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

13616:TK1
gene id: 13616:TK1
uniprot id: F6SP09
names: Similarity
messages: Belongs to the thymidine kinase family.

13616:GSTCD
gene id: 13616:GSTCD
uniprot id: F6ZAN7
names: Similarity
messages: Belongs to the GSTCD family.

13616:HMOX1
gene id: 13616:HMOX1
uniprot id: F7CK49
names: Similarity
messages: Belongs to the heme oxygenase family.

13616:MRAP2
gene id: 13616:MRAP2
uniprot id: F6PPU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:GPM6B
gene id: 13616:GPM6B
uniprot id: A0A5F8G329
uniprot id: F6S463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

13616:LOC100618665
gene id: 13616:LOC100618665
uniprot id: F7BX16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:BST1
gene id: 13616:BST1
uniprot id: F6ZFG5
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

13616:PIGM
gene id: 13616:PIGM
uniprot id: F6USQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

13616:ILF3
gene id: 13616:ILF3
uniprot id: A0A5F8HE55
uniprot id: F6XCW7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:SULF2
gene id: 13616:SULF2
uniprot id: A0A5F8GIW6
uniprot id: F7C2B7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:CLVS1
gene id: 13616:CLVS1
uniprot id: F7CDW7
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

13616:LGMN
gene id: 13616:LGMN
uniprot id: F6YEF8
names: Similarity
messages: Belongs to the peptidase C13 family.

13616:TPRG1L
gene id: 13616:TPRG1L
uniprot id: K7DZC4
names: Similarity
messages: Belongs to the TPRG1 family.

13616:MRPL33
gene id: 13616:MRPL33
uniprot id: F6ZV32
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

13616:RGMA
gene id: 13616:RGMA
uniprot id: F7G293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

13616:OSBPL11
gene id: 13616:OSBPL11
uniprot id: F6QV52
names: Similarity
messages: Belongs to the OSBP family.

13616:TAF1B
gene id: 13616:TAF1B
uniprot id: F6YN56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

13616:HMGN2
gene id: 13616:HMGN2
uniprot id: F7GFJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

13616:LOC100026355
gene id: 13616:LOC100026355
uniprot id: F6XCC9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:OTUB2
gene id: 13616:OTUB2
uniprot id: A0A5F8GCF4
uniprot id: A0A5F8HBX7
names: Similarity
messages: Belongs to the peptidase C65 family.

13616:ANAPC13
gene id: 13616:ANAPC13
uniprot id: F7B352
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

13616:BCL7B
gene id: 13616:BCL7B
uniprot id: F6UB62
names: Similarity
messages: Belongs to the BCL7 family.

13616:ANAPC15
gene id: 13616:ANAPC15
uniprot id: F6Z9Y0
names: Similarity
messages: Belongs to the APC15 family.

13616:ITPKB
gene id: 13616:ITPKB
uniprot id: F7F126
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

13616:LAP3
gene id: 13616:LAP3
uniprot id: F7BHR0
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

13616:KIF13A
gene id: 13616:KIF13A
uniprot id: A0A5F8HK25
uniprot id: F6S7Y0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:DDX43
gene id: 13616:DDX43
uniprot id: F7GCW4
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:LOC100010381
gene id: 13616:LOC100010381
uniprot id: F6U2E9
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:LOC100617479
gene id: 13616:LOC100617479
uniprot id: F7EI98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:STC2
gene id: 13616:STC2
uniprot id: F7BSU8
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

13616:monDomV1R1272
gene id: 13616:monDomV1R1272
uniprot id: A0A5F8HED0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RRN3
gene id: 13616:RRN3
uniprot id: F6QIM4
names: Similarity
messages: Belongs to the RRN3 family.

13616:MBOAT2
gene id: 13616:MBOAT2
uniprot id: F7E818
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100018630
gene id: 13616:LOC100018630
uniprot id: A0A5F8HDC6
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

13616:OTOP2
gene id: 13616:OTOP2
uniprot id: F6UF84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

13616:LOC100016060
gene id: 13616:LOC100016060
uniprot id: F7GH03
names: Similarity
messages: Belongs to the globin family.

13616:UCKL1
gene id: 13616:UCKL1
uniprot id: A0A5F8GEJ6
uniprot id: A0A5F8H2N1
uniprot id: F6Y033
names: Similarity
messages: Belongs to the uridine kinase family.

13616:GABRA5
gene id: 13616:GABRA5
uniprot id: F7C2S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:GJC1
gene id: 13616:GJC1
uniprot id: F6T5B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:PTH2R
gene id: 13616:PTH2R
uniprot id: A0A5F8HFW8
uniprot id: F7BR47
names: Subcellular Location Annotation
messages: Membrane

13616:PPP4C
gene id: 13616:PPP4C
uniprot id: F7E0S5
names: Similarity
messages: Belongs to the PPP phosphatase family.

13616:ARHGAP26
gene id: 13616:ARHGAP26
uniprot id: A0A5F8HHJ8
uniprot id: A0A5F8HHU2
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

13616:UFL1
gene id: 13616:UFL1
uniprot id: A0A5F8HF34
names: Similarity
messages: Belongs to the UFL1 family.

13616:HTR1F
gene id: 13616:HTR1F
uniprot id: A0A5F8H0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

13616:FAM229A
gene id: 13616:FAM229A
uniprot id: F6ZTY7
names: Similarity
messages: Belongs to the FAM229 family.

13616:RPS7
gene id: 13616:RPS7
uniprot id: F7FKL8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

13616:PLK1
gene id: 13616:PLK1
uniprot id: F7F258
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

13616:LOC100015414
gene id: 13616:LOC100015414
uniprot id: A0A5F8G2Y9
uniprot id: F7CVP0
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

13616:IER3IP1
gene id: 13616:IER3IP1
uniprot id: A0A5F8GHG0
names: Similarity
messages: Belongs to the YOS1 family.

13616:LTN1
gene id: 13616:LTN1
uniprot id: F6RK02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

13616:SST
gene id: 13616:SST
uniprot id: F7FTG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

13616:UGP2
gene id: 13616:UGP2
uniprot id: A0A5F8HI35
uniprot id: F6PIH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

13616:HEXDC
gene id: 13616:HEXDC
uniprot id: F6SI50
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

13616:STK17B
gene id: 13616:STK17B
uniprot id: F7FU71
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:CSNK2B
gene id: 13616:CSNK2B
uniprot id: A0A5F8GWR8
uniprot id: A0A5F8HE66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

13616:FITM1
gene id: 13616:FITM1
uniprot id: F7GBQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

13616:CALR
gene id: 13616:CALR
uniprot id: F6QXX7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

13616:ARFGEF1
gene id: 13616:ARFGEF1
uniprot id: F7AWY8
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

13616:GALM
gene id: 13616:GALM
uniprot id: F6PGL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

13616:TGFBR2
gene id: 13616:TGFBR2
uniprot id: F7CFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

13616:TNFAIP6
gene id: 13616:TNFAIP6
uniprot id: F7C6K7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PEX2
gene id: 13616:PEX2
uniprot id: F6U9L6
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

13616:GLIPR1
gene id: 13616:GLIPR1
uniprot id: F7A3E5
names: Similarity
messages: Belongs to the CRISP family.

13616:LOC103106071
gene id: 13616:LOC103106071
uniprot id: F7FTI4
names: Subcellular Location Annotation
messages: Nucleus

13616:STRIP2
gene id: 13616:STRIP2
uniprot id: F7E828
names: Similarity
messages: Belongs to the STRIP family.

13616:LOC103095510
gene id: 13616:LOC103095510
uniprot id: A0A5F8GUA5
names: Similarity
messages: Belongs to the MS4A family.

13616:CCDC85A
gene id: 13616:CCDC85A
uniprot id: A0A5F8GEQ2
uniprot id: A0A5F8H9J9
uniprot id: A0A5F8HD03
uniprot id: F6QCP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

13616:FOXO3
gene id: 13616:FOXO3
uniprot id: F7B7W4
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC28A3
gene id: 13616:SLC28A3
uniprot id: F7F2P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

13616:HOMER3
gene id: 13616:HOMER3
uniprot id: F7AAG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

13616:CKAP2L
gene id: 13616:CKAP2L
uniprot id: F6X5H0
names: Similarity
messages: Belongs to the CKAP2 family.

13616:JUP
gene id: 13616:JUP
uniprot id: F7DNP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

13616:HEATR5B
gene id: 13616:HEATR5B
uniprot id: A0A5F8H7P6
names: Similarity
messages: Belongs to the HEATR5 family.

13616:KLHL3
gene id: 13616:KLHL3
uniprot id: A0A5F8HB99
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

13616:PDE5A
gene id: 13616:PDE5A
uniprot id: F7GAS1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:UFD1L
gene id: 13616:UFD1L
uniprot id: F6TB32
names: Similarity
messages: Belongs to the UFD1 family.

13616:TMEM55A
gene id: 13616:TMEM55A
uniprot id: F7FZZ9
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

13616:CLTC
gene id: 13616:CLTC
uniprot id: F7ATX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

13616:LOC100030680
gene id: 13616:LOC100030680
uniprot id: F6YEH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:LPCAT4
gene id: 13616:LPCAT4
uniprot id: F6WZ01
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:TMEM98
gene id: 13616:TMEM98
uniprot id: A0A5F8HIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

13616:CLK1
gene id: 13616:CLK1
uniprot id: F7BXF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100019690
gene id: 13616:LOC100019690
uniprot id: F6YH14
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:PHTF1
gene id: 13616:PHTF1
uniprot id: F6S9T7
names: Subcellular Location Annotation
messages: Membrane

13616:SNRPF
gene id: 13616:SNRPF
uniprot id: F7GFW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

13616:T2R41
gene id: 13616:T2R41
uniprot id: Q2AB86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:HN1
gene id: 13616:HN1
uniprot id: A0A5F8GUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

13616:SEMA3A
gene id: 13616:SEMA3A
uniprot id: F6Q9V8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:AMPD2
gene id: 13616:AMPD2
uniprot id: F6W0Z6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

13616:CFDP1
gene id: 13616:CFDP1
uniprot id: A0A5F8HGI5
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

13616:PPM1G
gene id: 13616:PPM1G
uniprot id: F7F0V5
names: Similarity
messages: Belongs to the PP2C family.

13616:FFAR1
gene id: 13616:FFAR1
uniprot id: F6W8J7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TAF7L
gene id: 13616:TAF7L
uniprot id: A0A5F8GHF7
uniprot id: F7GDZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

13616:PALMD
gene id: 13616:PALMD
uniprot id: A0A5F8GCZ2
uniprot id: F7DTP3
names: Similarity
messages: Belongs to the paralemmin family.

13616:PPP2CB
gene id: 13616:PPP2CB
uniprot id: F7CP86
names: Similarity
messages: Belongs to the PPP phosphatase family.

13616:LMX1A
gene id: 13616:LMX1A
uniprot id: F7CIX3
names: Subcellular Location Annotation
messages: Nucleus

13616:PGP
gene id: 13616:PGP
uniprot id: F6PJ49
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

13616:ST3GAL6
gene id: 13616:ST3GAL6
uniprot id: F7G310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:NHSL1
gene id: 13616:NHSL1
uniprot id: A0A5F8HHA7
uniprot id: F6SKV8
names: Similarity
messages: Belongs to the NHS family.

13616:TPM1
gene id: 13616:TPM1
uniprot id: A0A5F8GVL9
uniprot id: A0A5F8H5I4
uniprot id: A0A5F8HBI3
uniprot id: A0A5F8HCJ2
uniprot id: A0A5F8HLP0
uniprot id: F7GGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

13616:ME1
gene id: 13616:ME1
uniprot id: F6QV43
names: Similarity
messages: Belongs to the malic enzymes family.

13616:OGG1
gene id: 13616:OGG1
uniprot id: F6ZEE7
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

13616:RAB4B
gene id: 13616:RAB4B
uniprot id: F7GI49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

13616:LOC100017631
gene id: 13616:LOC100017631
uniprot id: F7DI19
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MYO1D
gene id: 13616:MYO1D
uniprot id: A0A5F8G4F8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:TMEM45B
gene id: 13616:TMEM45B
uniprot id: F7C2F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

13616:NSMCE2
gene id: 13616:NSMCE2
uniprot id: K7E4G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

13616:LOC100028592
gene id: 13616:LOC100028592
uniprot id: F7AKM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LPGAT1
gene id: 13616:LPGAT1
uniprot id: A0A5F8GGG2
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:SLU7
gene id: 13616:SLU7
uniprot id: A0A5F8GFE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

13616:EDC3
gene id: 13616:EDC3
uniprot id: A0A5F8G2Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

13616:NUP133
gene id: 13616:NUP133
uniprot id: F7G2C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

13616:GRIA2
gene id: 13616:GRIA2
uniprot id: A0A5F8G9Y0
uniprot id: A0A5F8GRU6
uniprot id: F6Y7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:LOC100015833
gene id: 13616:LOC100015833
uniprot id: A0A5F8GHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

13616:RAD21L1
gene id: 13616:RAD21L1
uniprot id: F6Z2B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

13616:LOC100017183
gene id: 13616:LOC100017183
uniprot id: F7A3G7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: gap junction

13616:BLOC1S6
gene id: 13616:BLOC1S6
uniprot id: F6ZSG2
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

13616:TSEN54
gene id: 13616:TSEN54
uniprot id: A0A5F8G7Q3
uniprot id: F7DWA7
names: Similarity
messages: Belongs to the SEN54 family.

13616:CPLX2
gene id: 13616:CPLX2
uniprot id: A0A5F8GFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

13616:CDPF1
gene id: 13616:CDPF1
uniprot id: F6V618
names: Similarity
messages: Belongs to the CDPF1 family.

13616:ELF5
gene id: 13616:ELF5
uniprot id: A0A5F8H773
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:AURKA
gene id: 13616:AURKA
uniprot id: F7ASA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

13616:ST6GALNAC4
gene id: 13616:ST6GALNAC4
uniprot id: A0A5F8GYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:CCKBR
gene id: 13616:CCKBR
uniprot id: A0A5F8G2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EIF4A1
gene id: 13616:EIF4A1
uniprot id: F6UEF7
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

13616:SERINC2
gene id: 13616:SERINC2
uniprot id: F6V419
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

13616:PSMD3
gene id: 13616:PSMD3
uniprot id: F7CS51
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

13616:KCNH5
gene id: 13616:KCNH5
uniprot id: F7GL29
names: Subcellular Location Annotation
messages: Membrane

13616:PMF1
gene id: 13616:PMF1
uniprot id: F6ZUU9
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

13616:PIAS1
gene id: 13616:PIAS1
uniprot id: A0A5F8G8A5
uniprot id: A0A5F8GDT2
uniprot id: F7B6F8
names: Similarity
messages: Belongs to the PIAS family.

13616:CAMSAP1
gene id: 13616:CAMSAP1
uniprot id: F7E1H7
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

13616:LOC100024209
gene id: 13616:LOC100024209
uniprot id: F6YHU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

13616:PQLC2
gene id: 13616:PQLC2
uniprot id: F7B3W8
names: Subcellular Location Annotation
messages: Membrane

13616:monDomV1R1221
gene id: 13616:monDomV1R1221
uniprot id: F7FEJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100016508
gene id: 13616:LOC100016508
uniprot id: A0A5F8HAT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

13616:E2F5
gene id: 13616:E2F5
uniprot id: F6WF79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:monDomV1R1233
gene id: 13616:monDomV1R1233
uniprot id: F7BV07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CREBL2
gene id: 13616:CREBL2
uniprot id: A0A5F8GBD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

13616:XKR8
gene id: 13616:XKR8
uniprot id: F7FWH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

13616:FAM171A1
gene id: 13616:FAM171A1
uniprot id: F6Y546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

13616:STX7
gene id: 13616:STX7
uniprot id: F7E0Z1
names: Similarity
messages: Belongs to the syntaxin family.

13616:MGAT5
gene id: 13616:MGAT5
uniprot id: A0A5F8GJJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

13616:HSPD1
gene id: 13616:HSPD1
uniprot id: F7GF46
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

13616:MFSD14B
gene id: 13616:MFSD14B
uniprot id: F6S9C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

13616:NKIRAS1
gene id: 13616:NKIRAS1
uniprot id: F6YKR4
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

13616:PPM1A
gene id: 13616:PPM1A
uniprot id: A0A5F8GDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

13616:LBR
gene id: 13616:LBR
uniprot id: F6TKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

13616:SLC12A1
gene id: 13616:SLC12A1
uniprot id: A0A5F8GVX4
uniprot id: F7CEB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

13616:SLC13A2
gene id: 13616:SLC13A2
uniprot id: F7C4K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

13616:GTDC1
gene id: 13616:GTDC1
uniprot id: A0A5F8GYN7
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

13616:COPG2
gene id: 13616:COPG2
uniprot id: A0A5F8G5D4
uniprot id: F7F762
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

13616:ACSL5
gene id: 13616:ACSL5
uniprot id: F6VQ12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

13616:TP53INP2
gene id: 13616:TP53INP2
uniprot id: F7DHX4
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

13616:TUBB4B
gene id: 13616:TUBB4B
uniprot id: A0A5F8HDJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:DZIP1L
gene id: 13616:DZIP1L
uniprot id: F7GCS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

13616:CPLX1
gene id: 13616:CPLX1
uniprot id: F6VKP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

13616:WNT2B
gene id: 13616:WNT2B
uniprot id: F7GH85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:DDX6
gene id: 13616:DDX6
uniprot id: F7DTA2
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:GPM6A
gene id: 13616:GPM6A
uniprot id: A0A5F8G322
uniprot id: F7FA92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

13616:TXNIP
gene id: 13616:TXNIP
uniprot id: K7E0W4
names: Similarity
messages: Belongs to the arrestin family.

13616:AMOT
gene id: 13616:AMOT
uniprot id: F6ZEG2
names: Similarity
messages: Belongs to the angiomotin family.

13616:ENSA
gene id: 13616:ENSA
uniprot id: F6ZMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

13616:PFDN4
gene id: 13616:PFDN4
uniprot id: A0A5F8G255
uniprot id: F7E8R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

13616:ACTR1B
gene id: 13616:ACTR1B
uniprot id: F7GIQ3
names: Similarity
messages: Belongs to the actin family.

13616:EHD3
gene id: 13616:EHD3
uniprot id: F6VZL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

13616:FAM210A
gene id: 13616:FAM210A
uniprot id: A0A5F8HCL9
names: Similarity
messages: Belongs to the FAM210 family.

13616:TMEM184A
gene id: 13616:TMEM184A
uniprot id: F7B328
names: Subcellular Location Annotation
messages: Membrane

13616:NME9
gene id: 13616:NME9
uniprot id: F7FRS4
names: Similarity
messages: Belongs to the NDK family.

13616:SPC24
gene id: 13616:SPC24
uniprot id: F7B3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

13616:ROMO1
gene id: 13616:ROMO1
uniprot id: F7BX66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

13616:HRH3
gene id: 13616:HRH3
uniprot id: F7D2C8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:MYO1C
gene id: 13616:MYO1C
uniprot id: A0A5F8GAW6
uniprot id: F6SRM2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:PDCD4
gene id: 13616:PDCD4
uniprot id: F7AUR7
names: Similarity
messages: Belongs to the PDCD4 family.

13616:RAB14
gene id: 13616:RAB14
uniprot id: F7DD10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

13616:LOC100028693
gene id: 13616:LOC100028693
uniprot id: F7ET94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MRPS18C
gene id: 13616:MRPS18C
uniprot id: F6Z9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

13616:TMEM65
gene id: 13616:TMEM65
uniprot id: F6SNF7
uniprot id: K7E246
names: Subcellular Location Annotation
messages: Membrane

13616:ADAMTS5
gene id: 13616:ADAMTS5
uniprot id: F6RJX5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:TIMM22
gene id: 13616:TIMM22
uniprot id: F6UAF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ADCK3
gene id: 13616:ADCK3
uniprot id: F7GCL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

13616:RAPGEF2
gene id: 13616:RAPGEF2
uniprot id: A0A5F8G549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

13616:TM9SF1
gene id: 13616:TM9SF1
uniprot id: F7EFZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

13616:DPYSL2
gene id: 13616:DPYSL2
uniprot id: A0A5F8G2L5
uniprot id: F7DMI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

13616:ARPC1A
gene id: 13616:ARPC1A
uniprot id: F7BZM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

13616:PI4KB
gene id: 13616:PI4KB
uniprot id: A0A5F8H4E4
uniprot id: F7DVF5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

13616:CHEK1
gene id: 13616:CHEK1
uniprot id: A0A5F8HJI8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

13616:COQ7
gene id: 13616:COQ7
uniprot id: F7B5L7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

13616:IKBKAP
gene id: 13616:IKBKAP
uniprot id: F6S334
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

13616:ECHDC1
gene id: 13616:ECHDC1
uniprot id: A0A5F8G3J6
uniprot id: F7GFX1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:RHCE
gene id: 13616:RHCE
uniprot id: F6QL35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

13616:SLC25A48
gene id: 13616:SLC25A48
uniprot id: A0A5F8HI58
uniprot id: F7A5G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:SFT2D3
gene id: 13616:SFT2D3
uniprot id: F6UC97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

13616:FOXI1
gene id: 13616:FOXI1
uniprot id: F6PV64
names: Subcellular Location Annotation
messages: Nucleus

13616:TMEM147
gene id: 13616:TMEM147
uniprot id: F6VBQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:EML5
gene id: 13616:EML5
uniprot id: A0A5F8H7C4
uniprot id: F6WDF5
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

13616:CDK5RAP2
gene id: 13616:CDK5RAP2
uniprot id: F7GLC9
names: Subcellular Location Annotation
messages: centrosome

13616:POU3F1
gene id: 13616:POU3F1
uniprot id: F7FHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

13616:ELF4
gene id: 13616:ELF4
uniprot id: A0A5F8H4W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:FSCN1
gene id: 13616:FSCN1
uniprot id: F6ZF84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

13616:LOC103104714
gene id: 13616:LOC103104714
uniprot id: A0A5F8G703
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100018050
gene id: 13616:LOC100018050
uniprot id: F6Y2D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

13616:LCN15
gene id: 13616:LCN15
uniprot id: F6VYX5
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:POPDC2
gene id: 13616:POPDC2
uniprot id: A0A5F8GAJ3
uniprot id: F6PGY0
names: Similarity
messages: Belongs to the popeye family.

13616:PIGX
gene id: 13616:PIGX
uniprot id: F7CU66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NTN3
gene id: 13616:NTN3
uniprot id: F6SLT4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ENPP6
gene id: 13616:ENPP6
uniprot id: F6W5E7
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

13616:PSMB1
gene id: 13616:PSMB1
uniprot id: F7F3A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:PEX5L
gene id: 13616:PEX5L
uniprot id: A0A5F8GMR7
uniprot id: A0A5F8GT00
uniprot id: A0A5F8H7I0
uniprot id: A0A5F8H894
uniprot id: F7G3U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

13616:KCNH8
gene id: 13616:KCNH8
uniprot id: F7G6S7
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

13616:LOC100021720
gene id: 13616:LOC100021720
uniprot id: A0A5F8GNQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CPNE7
gene id: 13616:CPNE7
uniprot id: A0A5F8GV78
names: Similarity
messages: Belongs to the copine family.

13616:LOC100027993
gene id: 13616:LOC100027993
uniprot id: F7AUS6
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

13616:DVL1
gene id: 13616:DVL1
uniprot id: F7G276
names: Similarity
messages: Belongs to the DSH family.

13616:SLC6A15
gene id: 13616:SLC6A15
uniprot id: F7F542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

13616:IFN3
gene id: 13616:IFN3
uniprot id: A8E6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:GJB6
gene id: 13616:GJB6
uniprot id: F6WYP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:CMTM8
gene id: 13616:CMTM8
uniprot id: F7BW18
names: Subcellular Location Annotation
messages: Membrane

13616:HSP90B1
gene id: 13616:HSP90B1
uniprot id: F7DFT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

13616:LOC100021543
gene id: 13616:LOC100021543
uniprot id: A0A5F8HFP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103093560
gene id: 13616:LOC103093560
uniprot id: F6Y6H3
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

13616:NAE1
gene id: 13616:NAE1
uniprot id: F7C8D9
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

13616:NOXA1
gene id: 13616:NOXA1
uniprot id: F6RVX3
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

13616:HTRA2
gene id: 13616:HTRA2
uniprot id: A0A5F8GT06
names: Similarity
messages: Belongs to the peptidase S1C family.

13616:INPP5D
gene id: 13616:INPP5D
uniprot id: A0A5F8GEZ3
uniprot id: A0A5F8HIU2
uniprot id: F7GAI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

13616:MIEF2
gene id: 13616:MIEF2
uniprot id: F6QNZ2
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

13616:HTRA3
gene id: 13616:HTRA3
uniprot id: F6ZXS4
names: Similarity
messages: Belongs to the peptidase S1C family.

13616:SLC6A12
gene id: 13616:SLC6A12
uniprot id: F6QVR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Interacts with LIN7C.
messages: Membrane
messages: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

13616:LOC100032740
gene id: 13616:LOC100032740
uniprot id: F6W9F0
names: Function
messages: May be involved in transcriptional regulation.

13616:LOC100028676
gene id: 13616:LOC100028676
uniprot id: F7AKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PSKH2
gene id: 13616:PSKH2
uniprot id: F7ELA1
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:DNAAF2
gene id: 13616:DNAAF2
uniprot id: F6S6H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

13616:LOC100012726
gene id: 13616:LOC100012726
uniprot id: A0A5F8HJR1
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

13616:LOC100016983
gene id: 13616:LOC100016983
uniprot id: F7F6C6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

13616:SUV39H2
gene id: 13616:SUV39H2
uniprot id: A0A5F8G1N6
uniprot id: F6VMZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

13616:UGGT1
gene id: 13616:UGGT1
uniprot id: F7B290
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

13616:SH2B3
gene id: 13616:SH2B3
uniprot id: F6VBG4
names: Similarity
messages: Belongs to the SH2B adapter family.

13616:MOS
gene id: 13616:MOS
uniprot id: F6RB09
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:EPHX1
gene id: 13616:EPHX1
uniprot id: F6SN50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:LOC100015203
gene id: 13616:LOC100015203
uniprot id: F6WM29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

13616:FBP2
gene id: 13616:FBP2
uniprot id: F7EJ99
names: Similarity
messages: Belongs to the FBPase class 1 family.

13616:STK38
gene id: 13616:STK38
uniprot id: F7C3H3
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:P4HA1
gene id: 13616:P4HA1
uniprot id: F6YBC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

13616:LOC100016464
gene id: 13616:LOC100016464
uniprot id: F7FXB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:PYY
gene id: 13616:PYY
uniprot id: F7GDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

13616:USP4
gene id: 13616:USP4
uniprot id: A0A5F8GLS6
uniprot id: F7C8N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

13616:LDB2
gene id: 13616:LDB2
uniprot id: F6ZHF4
names: Similarity
messages: Belongs to the LDB family.

13616:ANKRD13A
gene id: 13616:ANKRD13A
uniprot id: F6SX00
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

13616:DTNB
gene id: 13616:DTNB
uniprot id: A0A5F8G2N2
uniprot id: A0A5F8GMX5
uniprot id: F7F0G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

13616:LOC100014733
gene id: 13616:LOC100014733
uniprot id: F6SW40
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

13616:USE1
gene id: 13616:USE1
uniprot id: F7G5D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100015328
gene id: 13616:LOC100015328
uniprot id: F7D750
names: Similarity
messages: Belongs to the intermediate filament family.

13616:RBP7
gene id: 13616:RBP7
uniprot id: F7E2J7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:TRHR
gene id: 13616:TRHR
uniprot id: F7AUF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

13616:LOC100012472
gene id: 13616:LOC100012472
uniprot id: F6WL75
names: Similarity
messages: Belongs to the peptidase M10A family.

13616:LOC100618039
gene id: 13616:LOC100618039
uniprot id: A0A5F8HG86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOXL1
gene id: 13616:LOXL1
uniprot id: F6RXA9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

13616:HPS5
gene id: 13616:HPS5
uniprot id: A0A5F8GFH8
uniprot id: F7B866
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

13616:HHAT
gene id: 13616:HHAT
uniprot id: F7FUH3
names: Subcellular Location Annotation
messages: Membrane

13616:BNIP1
gene id: 13616:BNIP1
uniprot id: A0A5F8H3B7
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100028379
gene id: 13616:LOC100028379
uniprot id: F6URR5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:SH3GL2
gene id: 13616:SH3GL2
uniprot id: F7BZ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

13616:FAM163A
gene id: 13616:FAM163A
uniprot id: F7AI30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

13616:AP1G2
gene id: 13616:AP1G2
uniprot id: F6YVC1
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

13616:BTF3
gene id: 13616:BTF3
uniprot id: A0A5F8HF00
names: Similarity
messages: Belongs to the NAC-beta family.

13616:RNF13
gene id: 13616:RNF13
uniprot id: F6T2X0
names: Subcellular Location Annotation
messages: Membrane

13616:CLDN15
gene id: 13616:CLDN15
uniprot id: F7ER03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:LOC100616785
gene id: 13616:LOC100616785
uniprot id: F7ER49
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:TMEM55B
gene id: 13616:TMEM55B
uniprot id: F7E374
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

13616:LCNL1
gene id: 13616:LCNL1
uniprot id: K7E5E8
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:VDAC3
gene id: 13616:VDAC3
uniprot id: A0A5F8HBY8
uniprot id: F6VI43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

13616:LOC100018242
gene id: 13616:LOC100018242
uniprot id: F6UWP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

13616:LOC100020352
gene id: 13616:LOC100020352
uniprot id: F6ZKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:LOC100013884
gene id: 13616:LOC100013884
uniprot id: F6TNB5
names: Similarity
messages: Belongs to the intermediate filament family.

13616:HOXD8
gene id: 13616:HOXD8
uniprot id: A0A5F8HJA7
uniprot id: F7A9D3
names: Subcellular Location Annotation
messages: Nucleus

13616:MEF2C
gene id: 13616:MEF2C
uniprot id: A0A5F8GFY9
uniprot id: A0A5F8H3R3
uniprot id: A0A5F8H4C6
uniprot id: F7FXI4
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100030569
gene id: 13616:LOC100030569
uniprot id: F7FRF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

13616:LOC100028243
gene id: 13616:LOC100028243
uniprot id: F7ELD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:LOC103094062
gene id: 13616:LOC103094062
uniprot id: K7E0X3
names: Similarity
messages: Belongs to the MS4A family.

13616:STAT4
gene id: 13616:STAT4
uniprot id: F7CW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

13616:NIT2
gene id: 13616:NIT2
uniprot id: F7GEI7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

13616:MRPS14
gene id: 13616:MRPS14
uniprot id: F6SVT1
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

13616:PLB1
gene id: 13616:PLB1
uniprot id: Q06HQ7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
messages: Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity).
messages: Repeat 2 contains the catalytic domain.
messages: Undergoes proteolytic cleavage in the ileum.

13616:SPIRE1
gene id: 13616:SPIRE1
uniprot id: A0A5F8GPS7
uniprot id: F7CBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

13616:ACER3
gene id: 13616:ACER3
uniprot id: A0A5F8H809
uniprot id: F7A1V8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LAMP2
gene id: 13616:LAMP2
uniprot id: F6W221
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

13616:LOC100019659
gene id: 13616:LOC100019659
uniprot id: K7E294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

13616:LOC100619324
gene id: 13616:LOC100619324
uniprot id: F6T9S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

13616:VN2R501
gene id: 13616:VN2R501
uniprot id: A0A5F8GMF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:AP1M2
gene id: 13616:AP1M2
uniprot id: F6U1G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

13616:UCK1
gene id: 13616:UCK1
uniprot id: F6PHT3
names: Similarity
messages: Belongs to the uridine kinase family.

13616:CASP2
gene id: 13616:CASP2
uniprot id: A0A5F8G6X9
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:LOC103102267
gene id: 13616:LOC103102267
uniprot id: F6PT66
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:MANEAL
gene id: 13616:MANEAL
uniprot id: K7E623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100027960
gene id: 13616:LOC100027960
uniprot id: A0A5F8G298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VN2R624
gene id: 13616:VN2R624
uniprot id: A0A5F8H261
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RPL22L1
gene id: 13616:RPL22L1
uniprot id: A0A5F8GTT4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

13616:TUBB3
gene id: 13616:TUBB3
uniprot id: F6ZPS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:ROCK2
gene id: 13616:ROCK2
uniprot id: A0A5F8HJP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: centrosome

13616:YIPF5
gene id: 13616:YIPF5
uniprot id: F6V7Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

13616:CPOX
gene id: 13616:CPOX
uniprot id: F6XHE8
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

13616:WIPI2
gene id: 13616:WIPI2
uniprot id: F6UUB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

13616:CYHR1
gene id: 13616:CYHR1
uniprot id: A0A5F8H580
uniprot id: F7F505
names: Similarity
messages: Belongs to the ZFTRAF1 family.

13616:HSD3B7
gene id: 13616:HSD3B7
uniprot id: F6WZW9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

13616:SLC25A18
gene id: 13616:SLC25A18
uniprot id: F7CUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:B4GAT1
gene id: 13616:B4GAT1
uniprot id: F7EK79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:PARVG
gene id: 13616:PARVG
uniprot id: A0A5F8GP47
uniprot id: F7EHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

13616:INPP4A
gene id: 13616:INPP4A
uniprot id: A0A5F8GHV0
uniprot id: F7GHC4
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

13616:ARF5
gene id: 13616:ARF5
uniprot id: F6V2X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

13616:TULP3
gene id: 13616:TULP3
uniprot id: F6PR86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

13616:LOC100014148
gene id: 13616:LOC100014148
uniprot id: F6QLJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RNF114
gene id: 13616:RNF114
uniprot id: A0A5F8G886
uniprot id: F7A674
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

13616:LSM7
gene id: 13616:LSM7
uniprot id: F6Y2R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

13616:HYLS1
gene id: 13616:HYLS1
uniprot id: F6UBS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

13616:SPG21
gene id: 13616:SPG21
uniprot id: F6YT13
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

13616:STARD3NL
gene id: 13616:STARD3NL
uniprot id: A0A5F8GHI8
uniprot id: F6PI71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

13616:VHL
gene id: 13616:VHL
uniprot id: F7CGX6
names: Similarity
messages: Belongs to the VHL family.

13616:OCIAD1
gene id: 13616:OCIAD1
uniprot id: F7EME9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

13616:IFNGR1
gene id: 13616:IFNGR1
uniprot id: F7AIU8
names: Similarity
messages: Belongs to the type II cytokine receptor family.

13616:DOK2
gene id: 13616:DOK2
uniprot id: A0A5F8G7D3
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

13616:LOC100028235
gene id: 13616:LOC100028235
uniprot id: A0A5F8HED8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ADAM15
gene id: 13616:ADAM15
uniprot id: A0A5F8GNU1
uniprot id: A0A5F8HBV1
uniprot id: F6U405
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100022567
gene id: 13616:LOC100022567
uniprot id: A0A5F8HBK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

13616:FAM167A
gene id: 13616:FAM167A
uniprot id: A0A5F8HI78
uniprot id: F7CV22
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

13616:CUL4B
gene id: 13616:CUL4B
uniprot id: F6S8D8
names: Similarity
messages: Belongs to the cullin family.

13616:MTIF2
gene id: 13616:MTIF2
uniprot id: F6T523
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

13616:LOC100020103
gene id: 13616:LOC100020103
uniprot id: A0A5F8HBA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100025505
gene id: 13616:LOC100025505
uniprot id: F6X6X2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:ING1
gene id: 13616:ING1
uniprot id: A0A5F8H4R4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:SLC13A1
gene id: 13616:SLC13A1
uniprot id: F6ZWA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

13616:LOC100617511
gene id: 13616:LOC100617511
uniprot id: F7EIA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMOD3
gene id: 13616:TMOD3
uniprot id: A0A5F8HFQ7
names: Subcellular Location Annotation
messages: cytoskeleton

13616:LOC100015867
gene id: 13616:LOC100015867
uniprot id: A0A5F8GHT3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CAP1
gene id: 13616:CAP1
uniprot id: F6Z972
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

13616:DTNBP1
gene id: 13616:DTNBP1
uniprot id: F7FK78
names: Similarity
messages: Belongs to the dysbindin family.

13616:PSPC1
gene id: 13616:PSPC1
uniprot id: F7CKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

13616:NDUFAB1
gene id: 13616:NDUFAB1
uniprot id: F7F775
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

13616:SLC28A1
gene id: 13616:SLC28A1
uniprot id: F6WTD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

13616:LOC100013629
gene id: 13616:LOC100013629
uniprot id: A0A5F8GGR0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:LOC100016313
gene id: 13616:LOC100016313
uniprot id: F6ZPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:S1PR5
gene id: 13616:S1PR5
uniprot id: F6QDA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:NANOG
gene id: 13616:NANOG
uniprot id: F7BUT7
names: Subcellular Location Annotation
messages: Nucleus

13616:MYO16
gene id: 13616:MYO16
uniprot id: F7AT26
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:SUMF2
gene id: 13616:SUMF2
uniprot id: F7EQ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

13616:LOC100618787
gene id: 13616:LOC100618787
uniprot id: A0A5F8HKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GPR180
gene id: 13616:GPR180
uniprot id: F7GAZ5
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100618318
gene id: 13616:LOC100618318
uniprot id: F7AWK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

13616:SDHB
gene id: 13616:SDHB
uniprot id: F6YGR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

13616:LOC100028935
gene id: 13616:LOC100028935
uniprot id: F7AWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100013359
gene id: 13616:LOC100013359
uniprot id: F7E7M6
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:ACSL6
gene id: 13616:ACSL6
uniprot id: A0A5F8G641
uniprot id: F6R4I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

13616:DKK2
gene id: 13616:DKK2
uniprot id: F6ZB66
names: Similarity
messages: Belongs to the dickkopf family.

13616:LOC100027566
gene id: 13616:LOC100027566
uniprot id: F6VRB5
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

13616:TIMP4
gene id: 13616:TIMP4
uniprot id: A0A5F8HLB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

13616:C4H11orf73
gene id: 13616:C4H11orf73
uniprot id: A0A5F8GB63
uniprot id: A0A5F8GNB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

13616:T2R21
gene id: 13616:T2R21
uniprot id: Q2AB98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:LOC100011919
gene id: 13616:LOC100011919
uniprot id: F6QTN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

13616:PIGG
gene id: 13616:PIGG
uniprot id: F6SKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:SUPT4H1
gene id: 13616:SUPT4H1
uniprot id: A0A5F8GER1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

13616:CALHM3
gene id: 13616:CALHM3
uniprot id: F7F4I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:IGFBP3
gene id: 13616:IGFBP3
uniprot id: F7EV06
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:TOR3A
gene id: 13616:TOR3A
uniprot id: F7FEZ8
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

13616:GPR62
gene id: 13616:GPR62
uniprot id: F7CBS2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100026384
gene id: 13616:LOC100026384
uniprot id: F6Z6F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:GCK
gene id: 13616:GCK
uniprot id: A0A5F8GL04
uniprot id: F7G8R6
names: Similarity
messages: Belongs to the hexokinase family.

13616:MCF2L
gene id: 13616:MCF2L
uniprot id: A0A5F8HA94
uniprot id: A0A5F8HBY1
uniprot id: A0A5F8HD32
uniprot id: F6VVG0
names: Subcellular Location Annotation
messages: Cytoplasm

13616:KRT222
gene id: 13616:KRT222
uniprot id: F7FA71
names: Similarity
messages: Belongs to the intermediate filament family.

13616:LOC100031277
gene id: 13616:LOC100031277
uniprot id: F7EI80
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

13616:ELF2
gene id: 13616:ELF2
uniprot id: A0A5F8GNZ5
uniprot id: F6Q8U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:PRSS16
gene id: 13616:PRSS16
uniprot id: F6PG02
names: Similarity
messages: Belongs to the peptidase S28 family.

13616:NOB1
gene id: 13616:NOB1
uniprot id: F7CYX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

13616:CDC42EP2
gene id: 13616:CDC42EP2
uniprot id: F7GG65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

13616:MRPL24
gene id: 13616:MRPL24
uniprot id: F7G680
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

13616:RAG1
gene id: 13616:RAG1
uniprot id: Q28463
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

13616:LDLR
gene id: 13616:LDLR
uniprot id: F7BQZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PTGDS
gene id: 13616:PTGDS
uniprot id: F6XCS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum
messages: perinuclear region

13616:ADCY7
gene id: 13616:ADCY7
uniprot id: F7G158
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:HHATL
gene id: 13616:HHATL
uniprot id: F6VVX3
names: Subcellular Location Annotation
messages: Membrane

13616:GPR31
gene id: 13616:GPR31
uniprot id: F7EI33
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100024252
gene id: 13616:LOC100024252
uniprot id: F7EI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103092471
gene id: 13616:LOC103092471
uniprot id: A0A5F8HDP5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:SPX
gene id: 13616:SPX
uniprot id: A0A5F8H2X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

13616:NANOS1
gene id: 13616:NANOS1
uniprot id: F7GJT4
names: Similarity
messages: Belongs to the nanos family.

13616:RNF168
gene id: 13616:RNF168
uniprot id: F6XBK7
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

13616:CCDC58
gene id: 13616:CCDC58
uniprot id: F6PW38
names: Similarity
messages: Belongs to the MIX23 family.

13616:VN2R588
gene id: 13616:VN2R588
uniprot id: A0A5F8GQR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:MVK
gene id: 13616:MVK
uniprot id: F6VQR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

13616:PTP4A1
gene id: 13616:PTP4A1
uniprot id: F7FQJ1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

13616:HSDL1
gene id: 13616:HSDL1
uniprot id: F7A6J2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:PIF1
gene id: 13616:PIF1
uniprot id: F7ET02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

13616:ACTG2
gene id: 13616:ACTG2
uniprot id: F7DQK7
names: Similarity
messages: Belongs to the actin family.

13616:MTNR1A
gene id: 13616:MTNR1A
uniprot id: F7F741
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

13616:CLIC1
gene id: 13616:CLIC1
uniprot id: F6UK56
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

13616:EIF5
gene id: 13616:EIF5
uniprot id: F7C537
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

13616:FIBIN
gene id: 13616:FIBIN
uniprot id: A0A5F8G2K8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

13616:CLDN10
gene id: 13616:CLDN10
uniprot id: A0A5F8G4T0
uniprot id: A0A5F8GY10
uniprot id: A0A5F8HF08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:LOC100616725
gene id: 13616:LOC100616725
uniprot id: F7C278
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DNAJA4
gene id: 13616:DNAJA4
uniprot id: F7GDZ8
names: Subcellular Location Annotation
messages: Membrane

13616:HESX1
gene id: 13616:HESX1
uniprot id: F7E2Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

13616:CERS6
gene id: 13616:CERS6
uniprot id: A0A5F8G7S2
uniprot id: K7E682
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:RNF7
gene id: 13616:RNF7
uniprot id: F6QK30
names: Similarity
messages: Belongs to the RING-box family.

13616:USP48
gene id: 13616:USP48
uniprot id: F7EFT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

13616:LOC100011195
gene id: 13616:LOC100011195
uniprot id: F7BV62
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:KIF2A
gene id: 13616:KIF2A
uniprot id: A0A5F8GVS6
uniprot id: F6Y7G9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:SEPT12
gene id: 13616:SEPT12
uniprot id: F7AHD6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

13616:LRP6
gene id: 13616:LRP6
uniprot id: A0A5F8GGM1
uniprot id: F6PG65
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:AVPR1B
gene id: 13616:AVPR1B
uniprot id: F6VJ30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

13616:LOC100023657
gene id: 13616:LOC100023657
uniprot id: F7C951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PDHX
gene id: 13616:PDHX
uniprot id: F7F2T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

13616:MAL2
gene id: 13616:MAL2
uniprot id: F7D7E1
names: Subcellular Location Annotation
messages: Membrane

13616:RXRG
gene id: 13616:RXRG
uniprot id: F7C094
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

13616:ACAT2
gene id: 13616:ACAT2
uniprot id: F6RDB9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

13616:HSD17B7
gene id: 13616:HSD17B7
uniprot id: F7GHF2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

13616:OLFML1
gene id: 13616:OLFML1
uniprot id: F7FER2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100024002
gene id: 13616:LOC100024002
uniprot id: F7GDY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HR
gene id: 13616:HR
uniprot id: F6S005
names: Subcellular Location Annotation
messages: Nucleus

13616:BMP4
gene id: 13616:BMP4
uniprot id: F7DWN3
names: Similarity
messages: Belongs to the TGF-beta family.

13616:LOC100009897
gene id: 13616:LOC100009897
uniprot id: F6PJJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GOLM1
gene id: 13616:GOLM1
uniprot id: F7ELM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

13616:LOC100011471
gene id: 13616:LOC100011471
uniprot id: F7C8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:CSTF2
gene id: 13616:CSTF2
uniprot id: F6QNJ2
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC9A8
gene id: 13616:SLC9A8
uniprot id: A0A5F8G8F0
uniprot id: F7A690
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

13616:TSC22D1
gene id: 13616:TSC22D1
uniprot id: A0A5F8GGE5
uniprot id: A0A5F8HA64
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

13616:HMGN1
gene id: 13616:HMGN1
uniprot id: F6S609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

13616:LOC100028276
gene id: 13616:LOC100028276
uniprot id: A0A5F8HB30
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:VRTN
gene id: 13616:VRTN
uniprot id: F7AG57
names: Similarity
messages: Belongs to the vertnin family.

13616:SEPT11
gene id: 13616:SEPT11
uniprot id: A0A5F8GLI5
uniprot id: F7GM08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

13616:DNAJC22
gene id: 13616:DNAJC22
uniprot id: F6Y900
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

13616:AK3
gene id: 13616:AK3
uniprot id: A0A5F8HGD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

13616:SUCLG1
gene id: 13616:SUCLG1
uniprot id: F6WVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

13616:ATF7IP
gene id: 13616:ATF7IP
uniprot id: F7B6U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

13616:CDKN1B
gene id: 13616:CDKN1B
uniprot id: F6PGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

13616:CTPS2
gene id: 13616:CTPS2
uniprot id: A0A5F8GAF2
uniprot id: F6XYN7
uniprot id: K7E4X2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

13616:ADAM12
gene id: 13616:ADAM12
uniprot id: F6ZF10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:HUS1
gene id: 13616:HUS1
uniprot id: F7AYQ2
names: Similarity
messages: Belongs to the HUS1 family.

13616:NFRKB
gene id: 13616:NFRKB
uniprot id: F7FX68
names: Subcellular Location Annotation
messages: Nucleus

13616:SLITRK6
gene id: 13616:SLITRK6
uniprot id: F6R8M5
names: Similarity
messages: Belongs to the SLITRK family.

13616:LOC103093750
gene id: 13616:LOC103093750
uniprot id: F7C584
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CEBPB
gene id: 13616:CEBPB
uniprot id: F7A5L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

13616:NPL
gene id: 13616:NPL
uniprot id: A0A5F8H8K2
uniprot id: F6PUU9
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

13616:XIRP2
gene id: 13616:XIRP2
uniprot id: A0A5F8GTW9
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

13616:LOC100026637
gene id: 13616:LOC100026637
uniprot id: A0A5F8GU97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:KIF25
gene id: 13616:KIF25
uniprot id: A0A5F8H1C2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:PACS2
gene id: 13616:PACS2
uniprot id: F7E808
names: Similarity
messages: Belongs to the PACS family.

13616:FNIP2
gene id: 13616:FNIP2
uniprot id: F6V094
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

13616:FIS1
gene id: 13616:FIS1
uniprot id: F7E999
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

13616:RBCK1
gene id: 13616:RBCK1
uniprot id: F6VDA7
names: Similarity
messages: Belongs to the RBR family.

13616:LOC100022920
gene id: 13616:LOC100022920
uniprot id: F6YEC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:SEMA3G
gene id: 13616:SEMA3G
uniprot id: F6VJZ6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:BZW1
gene id: 13616:BZW1
uniprot id: A0A5F8GPI7
names: Similarity
messages: Belongs to the BZW family.

13616:AMZ1
gene id: 13616:AMZ1
uniprot id: F6TG05
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

13616:FBXO25
gene id: 13616:FBXO25
uniprot id: A0A5F8HH52
uniprot id: A0A5F8HHB7
names: Subcellular Location Annotation
messages: Nucleus

13616:TAF12
gene id: 13616:TAF12
uniprot id: A0A5F8GBI8
uniprot id: A0A5F8HHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

13616:LGI1
gene id: 13616:LGI1
uniprot id: A0A5F8H271
uniprot id: F6XG60
names: Subcellular Location Annotation
messages: Secreted

13616:LOC100015642
gene id: 13616:LOC100015642
uniprot id: M9MMH7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:NARF
gene id: 13616:NARF
uniprot id: F6RZA8
names: Similarity
messages: Belongs to the NARF family.

13616:FOXF2
gene id: 13616:FOXF2
uniprot id: F7FGY5
names: Subcellular Location Annotation
messages: Nucleus

13616:BTF3L4
gene id: 13616:BTF3L4
uniprot id: F6SSU1
names: Similarity
messages: Belongs to the NAC-beta family.

13616:AP2S1
gene id: 13616:AP2S1
uniprot id: F7FQU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

13616:PLCG2
gene id: 13616:PLCG2
uniprot id: F7BVQ1
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

13616:SAMHD1
gene id: 13616:SAMHD1
uniprot id: F7CIF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

13616:THRB
gene id: 13616:THRB
uniprot id: A0A5F8G8X0
uniprot id: A0A5F8GH58
uniprot id: F7G6F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:MSX1
gene id: 13616:MSX1
uniprot id: F7EMU7
names: Subcellular Location Annotation
messages: Nucleus

13616:ANXA5
gene id: 13616:ANXA5
uniprot id: F7GJP3
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

13616:TMEM230
gene id: 13616:TMEM230
uniprot id: F6YEP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

13616:TMCC3
gene id: 13616:TMCC3
uniprot id: F7FTZ9
names: Similarity
messages: Belongs to the TEX28 family.

13616:KIF5C
gene id: 13616:KIF5C
uniprot id: F7GBT8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:TMED5
gene id: 13616:TMED5
uniprot id: F7C2E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

13616:RBBP7
gene id: 13616:RBBP7
uniprot id: F6QE05
names: Subcellular Location Annotation
messages: Nucleus

13616:CNNM2
gene id: 13616:CNNM2
uniprot id: A0A5F8GKR4
uniprot id: A0A5F8H6Z0
uniprot id: F6ZZU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

13616:EPHA8
gene id: 13616:EPHA8
uniprot id: F7EB26
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100016987
gene id: 13616:LOC100016987
uniprot id: F6RWK2
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:FAM168B
gene id: 13616:FAM168B
uniprot id: F7B2L4
names: Similarity
messages: Belongs to the FAM168 family.

13616:LOC103106765
gene id: 13616:LOC103106765
uniprot id: K7E3N5
names: Subcellular Location Annotation
messages: Nucleus

13616:POU4F3
gene id: 13616:POU4F3
uniprot id: F6WMZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

13616:ZDHHC1
gene id: 13616:ZDHHC1
uniprot id: F6WW01
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:LOC100017379
gene id: 13616:LOC100017379
uniprot id: F7DFY5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

13616:LOC100026332
gene id: 13616:LOC100026332
uniprot id: F7GDK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SCUBE3
gene id: 13616:SCUBE3
uniprot id: A0A5F8GUZ2
uniprot id: A0A5F8H314
uniprot id: F6SEA3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:GSR
gene id: 13616:GSR
uniprot id: F7CP75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

13616:MYO5B
gene id: 13616:MYO5B
uniprot id: A0A5F8GP95
uniprot id: F7DUZ7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:MSRA
gene id: 13616:MSRA
uniprot id: A0A5F8G7S7
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

13616:RTBDN
gene id: 13616:RTBDN
uniprot id: K7E4M5
names: Similarity
messages: Belongs to the folate receptor family.

13616:NOP14
gene id: 13616:NOP14
uniprot id: F7EDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

13616:TREH
gene id: 13616:TREH
uniprot id: F7D8S1
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

13616:TRAPPC1
gene id: 13616:TRAPPC1
uniprot id: F7G005
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

13616:SLC2A1
gene id: 13616:SLC2A1
uniprot id: F6TLZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Photoreceptor inner segment

13616:COLGALT1
gene id: 13616:COLGALT1
uniprot id: F6W8D5
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

13616:MRPL22
gene id: 13616:MRPL22
uniprot id: F7CXK5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

13616:SLC30A7
gene id: 13616:SLC30A7
uniprot id: F7DX04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

13616:C1H16orf70
gene id: 13616:C1H16orf70
uniprot id: F7AGW7
names: Similarity
messages: Belongs to the PHAF1 family.

13616:EMC3
gene id: 13616:EMC3
uniprot id: F6YL58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

13616:C6
gene id: 13616:C6
uniprot id: F7BFY4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:NFKB1
gene id: 13616:NFKB1
uniprot id: F7DLB9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:NDUFB7
gene id: 13616:NDUFB7
uniprot id: F7G4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

13616:SLC30A10
gene id: 13616:SLC30A10
uniprot id: F6X6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

13616:AKAP8
gene id: 13616:AKAP8
uniprot id: F7ASS2
names: Similarity
messages: Belongs to the AKAP95 family.

13616:VGLL2
gene id: 13616:VGLL2
uniprot id: A0A5F8GL17
uniprot id: F6ZY15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

13616:LOC100012973
gene id: 13616:LOC100012973
uniprot id: F6WQN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RAMP3
gene id: 13616:RAMP3
uniprot id: A0A5F8G309
uniprot id: F6W6P3
names: Similarity
messages: Belongs to the RAMP family.

13616:PRM1
gene id: 13616:PRM1
uniprot id: P67836
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

13616:PPP1R14D
gene id: 13616:PPP1R14D
uniprot id: F6SZL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

13616:LOC100021695
gene id: 13616:LOC100021695
uniprot id: F7FDA3
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Homotetramer.

13616:GLB1L
gene id: 13616:GLB1L
uniprot id: A0A5F8GCM0
uniprot id: F6TM00
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

13616:NUP210
gene id: 13616:NUP210
uniprot id: F6PHA8
names: Similarity
messages: Belongs to the NUP210 family.

13616:TMEM14C
gene id: 13616:TMEM14C
uniprot id: F6XWW6
names: Similarity
messages: Belongs to the TMEM14 family.

13616:AP4E1
gene id: 13616:AP4E1
uniprot id: A0A5F8H008
names: Function
names: Similarity
names: Subunit
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

13616:TUBA8
gene id: 13616:TUBA8
uniprot id: F7CAU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

13616:SLC35F2
gene id: 13616:SLC35F2
uniprot id: F7E7K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

13616:PRND
gene id: 13616:PRND
uniprot id: A2BDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

13616:TFF2
gene id: 13616:TFF2
uniprot id: F6QZC5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TMEM134
gene id: 13616:TMEM134
uniprot id: F6WJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

13616:ADAT2
gene id: 13616:ADAT2
uniprot id: F6T4D9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

13616:GAP43
gene id: 13616:GAP43
uniprot id: F7BTK7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

13616:NOL11
gene id: 13616:NOL11
uniprot id: F7FYT0
names: Subcellular Location Annotation
messages: nucleolus

13616:MAP7
gene id: 13616:MAP7
uniprot id: A0A5F8H4Z3
uniprot id: A0A5F8HE63
names: Similarity
messages: Belongs to the MAP7 family.

13616:LOC100011049
gene id: 13616:LOC100011049
uniprot id: F6YRT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RXRB
gene id: 13616:RXRB
uniprot id: A0A5F8H805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

13616:CAV1
gene id: 13616:CAV1
uniprot id: F7FDW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: Membrane raft
messages: caveola

13616:UBA52
gene id: 13616:UBA52
uniprot id: F7CRY4
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

13616:LIAS
gene id: 13616:LIAS
uniprot id: F7AQ30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

13616:LOC100019025
gene id: 13616:LOC100019025
uniprot id: F6V6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GSTZ1
gene id: 13616:GSTZ1
uniprot id: A0A5F8HAS3
uniprot id: F7D0R6
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

13616:GMPPA
gene id: 13616:GMPPA
uniprot id: A0A5F8GDJ4
uniprot id: F7F3V5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

13616:NPNT
gene id: 13616:NPNT
uniprot id: A0A5F8H0E4
uniprot id: A0A5F8H223
uniprot id: F6ZAS9
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DHX15
gene id: 13616:DHX15
uniprot id: F6Y5H8
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

13616:HEATR1
gene id: 13616:HEATR1
uniprot id: F7G8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

13616:NINJ1
gene id: 13616:NINJ1
uniprot id: A0A5F8GHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

13616:LOC103105715
gene id: 13616:LOC103105715
uniprot id: K7E3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:RPS3
gene id: 13616:RPS3
uniprot id: F6RG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: nucleolus
messages: spindle

13616:C4H1orf174
gene id: 13616:C4H1orf174
uniprot id: F7F2Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

13616:VPS4B
gene id: 13616:VPS4B
uniprot id: A0A5F8H303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

13616:PELI1
gene id: 13616:PELI1
uniprot id: F6TZ95
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

13616:MYOZ2
gene id: 13616:MYOZ2
uniprot id: A0A5F8GPB1
names: Similarity
messages: Belongs to the myozenin family.

13616:FAM76B
gene id: 13616:FAM76B
uniprot id: A0A5F8G5E9
uniprot id: A0A5F8G6B2
names: Similarity
messages: Belongs to the FAM76 family.

13616:LOC100015860
gene id: 13616:LOC100015860
uniprot id: F7G1Y8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:FAM126A
gene id: 13616:FAM126A
uniprot id: A0A5F8HH95
uniprot id: F7DPN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

13616:KIF20B
gene id: 13616:KIF20B
uniprot id: F6SHK6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:KCNJ13
gene id: 13616:KCNJ13
uniprot id: F6YR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

13616:BAP1
gene id: 13616:BAP1
uniprot id: F6RI15
names: Similarity
messages: Belongs to the peptidase C12 family.

13616:SGMS2
gene id: 13616:SGMS2
uniprot id: A0A5F8G2Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

13616:PROK1
gene id: 13616:PROK1
uniprot id: A0A5F8H910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

13616:BATF
gene id: 13616:BATF
uniprot id: F6XD41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

13616:MAL
gene id: 13616:MAL
uniprot id: A0A5F8G6T8
names: Subcellular Location Annotation
messages: Membrane

13616:TNFRSF1A
gene id: 13616:TNFRSF1A
uniprot id: F7G4G9
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100024719
gene id: 13616:LOC100024719
uniprot id: A0A5F8HA08
names: Similarity
messages: Belongs to the MHC class I family.

13616:SLC12A9
gene id: 13616:SLC12A9
uniprot id: F6V5G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

13616:VN2R598
gene id: 13616:VN2R598
uniprot id: F7FK66
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:EPT1
gene id: 13616:EPT1
uniprot id: F7FRZ9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

13616:DUSP2
gene id: 13616:DUSP2
uniprot id: F6YIH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

13616:ST6GALNAC6
gene id: 13616:ST6GALNAC6
uniprot id: A0A5F8HDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:GTF2F2
gene id: 13616:GTF2F2
uniprot id: F6QZ41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

13616:PAX3
gene id: 13616:PAX3
uniprot id: F6XVW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

13616:FAM208B
gene id: 13616:FAM208B
uniprot id: F7B3T1
names: Similarity
messages: Belongs to the TASOR family.

13616:B3GNT3
gene id: 13616:B3GNT3
uniprot id: F7BK30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100017621
gene id: 13616:LOC100017621
uniprot id: A0A5F8GGA4
uniprot id: A0A5F8GQJ6
uniprot id: F6X7K6
names: Similarity
messages: Belongs to the Luc7 family.

13616:ADIPOR2
gene id: 13616:ADIPOR2
uniprot id: F6XUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:POLH
gene id: 13616:POLH
uniprot id: F7G0E4
names: Subcellular Location Annotation
messages: Nucleus

13616:TPRG1
gene id: 13616:TPRG1
uniprot id: F7FUV1
names: Similarity
messages: Belongs to the TPRG1 family.

13616:LOC100028578
gene id: 13616:LOC100028578
uniprot id: F7EBH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MEIS2
gene id: 13616:MEIS2
uniprot id: A0A5F8H950
uniprot id: F7CIR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

13616:HNMT
gene id: 13616:HNMT
uniprot id: A0A5F8H7S0
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

13616:NR1D2
gene id: 13616:NR1D2
uniprot id: F7GGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:SYT1
gene id: 13616:SYT1
uniprot id: F7FJ84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

13616:LOC100011820
gene id: 13616:LOC100011820
uniprot id: K7E1T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:DLST
gene id: 13616:DLST
uniprot id: F7E1R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

13616:LOC100016082
gene id: 13616:LOC100016082
uniprot id: A0A5F8HE86
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

13616:HDAC5
gene id: 13616:HDAC5
uniprot id: A0A5F8GB78
uniprot id: F7G734
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

13616:MRPL41
gene id: 13616:MRPL41
uniprot id: F6SEJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

13616:PISD
gene id: 13616:PISD
uniprot id: F6TFC0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

13616:TRAM2
gene id: 13616:TRAM2
uniprot id: F6YZB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

13616:MTIF3
gene id: 13616:MTIF3
uniprot id: F7G2D6
names: Similarity
messages: Belongs to the IF-3 family.

13616:SARM1
gene id: 13616:SARM1
uniprot id: F6QTG2
names: Similarity
messages: Belongs to the SARM1 family.

13616:GPR37L1
gene id: 13616:GPR37L1
uniprot id: F6X490
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TRAF6
gene id: 13616:TRAF6
uniprot id: F6SAI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

13616:DDX31
gene id: 13616:DDX31
uniprot id: A0A5F8GZ27
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:PANX3
gene id: 13616:PANX3
uniprot id: A0A5F8GYX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

13616:OVOL2
gene id: 13616:OVOL2
uniprot id: F7GFR3
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100031088
gene id: 13616:LOC100031088
uniprot id: A0A5F8GQ73
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

13616:DOK4
gene id: 13616:DOK4
uniprot id: F7C3J4
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

13616:S100A10
gene id: 13616:S100A10
uniprot id: A0A5F8HK80
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

13616:LOC100017002
gene id: 13616:LOC100017002
uniprot id: A0A5F8HD01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DACT2
gene id: 13616:DACT2
uniprot id: F6TV63
names: Similarity
messages: Belongs to the dapper family.

13616:EDN1
gene id: 13616:EDN1
uniprot id: F6YR31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

13616:LOC100019741
gene id: 13616:LOC100019741
uniprot id: F7FVN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

13616:ANXA3
gene id: 13616:ANXA3
uniprot id: A0A5F8H2F7
uniprot id: F6S7A7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:RPL3
gene id: 13616:RPL3
uniprot id: F7C419
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

13616:LOC103102651
gene id: 13616:LOC103102651
uniprot id: A0A5F8GQ48
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

13616:LOC100023334
gene id: 13616:LOC100023334
uniprot id: F6Q121
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100024846
gene id: 13616:LOC100024846
uniprot id: F7GIH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100616991
gene id: 13616:LOC100616991
uniprot id: F7D5M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DSE
gene id: 13616:DSE
uniprot id: F6Z8C6
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

13616:VPS45
gene id: 13616:VPS45
uniprot id: F7AE31
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

13616:DUSP26
gene id: 13616:DUSP26
uniprot id: F7EMZ0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

13616:RTCA
gene id: 13616:RTCA
uniprot id: F7GBC6
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

13616:TIMM23B
gene id: 13616:TIMM23B
uniprot id: F7DI36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

13616:CA8
gene id: 13616:CA8
uniprot id: F7CX54
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

13616:PRR15L
gene id: 13616:PRR15L
uniprot id: F7FVM6
names: Similarity
messages: Belongs to the PRR15 family.

13616:ASZ1
gene id: 13616:ASZ1
uniprot id: F6Z443
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.

13616:GRINA
gene id: 13616:GRINA
uniprot id: F7A787
names: Subcellular Location Annotation
messages: Membrane

13616:AGL
gene id: 13616:AGL
uniprot id: F7GJD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

13616:TCTEX1D4
gene id: 13616:TCTEX1D4
uniprot id: A0A5F8HFR1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

13616:VN2R615
gene id: 13616:VN2R615
uniprot id: F7DRE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SCG2
gene id: 13616:SCG2
uniprot id: F7FCM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

13616:NXPE3
gene id: 13616:NXPE3
uniprot id: A0A5F8GH75
uniprot id: F6WGG1
names: Similarity
messages: Belongs to the NXPE family.

13616:T2R22
gene id: 13616:T2R22
uniprot id: Q2AB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:PANK4
gene id: 13616:PANK4
uniprot id: F7DJ58
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA.
messages: Belongs to the type II pantothenate kinase family.
messages: Cytoplasm
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.
messages: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.

13616:EEF1B2
gene id: 13616:EEF1B2
uniprot id: F7EG66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

13616:NME2
gene id: 13616:NME2
uniprot id: F6PJ02
names: Similarity
messages: Belongs to the NDK family.

13616:DST
gene id: 13616:DST
uniprot id: A0A5F8GK48
names: Subcellular Location Annotation
messages: cytoskeleton

13616:NDE1
gene id: 13616:NDE1
uniprot id: F6SVX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

13616:LYG2
gene id: 13616:LYG2
uniprot id: F7FWC5
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

13616:COPB1
gene id: 13616:COPB1
uniprot id: F7EEU7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

13616:DRC1
gene id: 13616:DRC1
uniprot id: F7FS23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

13616:VN2R533
gene id: 13616:VN2R533
uniprot id: F6W3N1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ADGRE5
gene id: 13616:ADGRE5
uniprot id: A0A5F8G271
uniprot id: A0A5F8HIY9
uniprot id: F7E0D4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CRYBA1
gene id: 13616:CRYBA1
uniprot id: F6XTA6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:TMEM251
gene id: 13616:TMEM251
uniprot id: F7G3F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

13616:MTG2
gene id: 13616:MTG2
uniprot id: F7D2H5
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

13616:PHTF2
gene id: 13616:PHTF2
uniprot id: A0A5F8GCD3
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100028079
gene id: 13616:LOC100028079
uniprot id: A0A5F8HDN2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:RAX
gene id: 13616:RAX
uniprot id: F7ARM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:B4GALT4
gene id: 13616:B4GALT4
uniprot id: F7B788
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:GAST
gene id: 13616:GAST
uniprot id: F7EQ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

13616:LOC100028402
gene id: 13616:LOC100028402
uniprot id: A0A5F8HIZ1
names: Subcellular Location Annotation
messages: Membrane

13616:PDX1
gene id: 13616:PDX1
uniprot id: F7BPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:CNOT6L
gene id: 13616:CNOT6L
uniprot id: A0A5F8GLP1
uniprot id: A0A5F8HK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

13616:TIMM21
gene id: 13616:TIMM21
uniprot id: A0A5F8GY61
uniprot id: A0A5F8HAD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

13616:KRT20
gene id: 13616:KRT20
uniprot id: F7C2V3
names: Similarity
messages: Belongs to the intermediate filament family.

13616:monDomV1R1207
gene id: 13616:monDomV1R1207
uniprot id: A0A5F8G5M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ITGA2B
gene id: 13616:ITGA2B
uniprot id: F6RI44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:LAMTOR5
gene id: 13616:LAMTOR5
uniprot id: F6UCS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

13616:SMARCAD1
gene id: 13616:SMARCAD1
uniprot id: A0A5F8H3I8
uniprot id: A0A5F8HA60
names: Subcellular Location Annotation
messages: Chromosome

13616:BBS2
gene id: 13616:BBS2
uniprot id: F7D8D3
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

13616:SLC19A2
gene id: 13616:SLC19A2
uniprot id: F6PLI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

13616:LOC103102160
gene id: 13616:LOC103102160
uniprot id: F7G1L0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PFKFB3
gene id: 13616:PFKFB3
uniprot id: A0A5F8G8V4
uniprot id: F7G783
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

13616:SLC9A5
gene id: 13616:SLC9A5
uniprot id: F7AJ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

13616:MRPL44
gene id: 13616:MRPL44
uniprot id: A0A5F8G5S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

13616:IRF3
gene id: 13616:IRF3
uniprot id: A0A5F8HKM1
uniprot id: F6VVK5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:MTFMT
gene id: 13616:MTFMT
uniprot id: F7A6V0
names: Similarity
messages: Belongs to the Fmt family.

13616:FERMT1
gene id: 13616:FERMT1
uniprot id: F6YTW9
names: Similarity
messages: Belongs to the kindlin family.

13616:MAF
gene id: 13616:MAF
uniprot id: F7G1L4
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

13616:NEU3
gene id: 13616:NEU3
uniprot id: A0A5F8H7G2
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

13616:CCND2
gene id: 13616:CCND2
uniprot id: F6PTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

13616:TMEM208
gene id: 13616:TMEM208
uniprot id: A0A5F8HBA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

13616:monDomV1R1251
gene id: 13616:monDomV1R1251
uniprot id: A0A5F8GZY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:C1H15orf65
gene id: 13616:C1H15orf65
uniprot id: A0A5F8GKW6
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

13616:LOC100018068
gene id: 13616:LOC100018068
uniprot id: F6QIS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ATP5A1
gene id: 13616:ATP5A1
uniprot id: F6THT5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

13616:PAM16
gene id: 13616:PAM16
uniprot id: A0A5F8GWL2
uniprot id: F7ER96
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

13616:WASL
gene id: 13616:WASL
uniprot id: F6TLC0
names: Subcellular Location Annotation
messages: Nucleus

13616:TNP1
gene id: 13616:TNP1
uniprot id: F6ZI63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

13616:FAM91A1
gene id: 13616:FAM91A1
uniprot id: F6W104
names: Similarity
messages: Belongs to the FAM91 family.

13616:ITK
gene id: 13616:ITK
uniprot id: F7FTR6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:ARV1
gene id: 13616:ARV1
uniprot id: F7GJN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

13616:MELK
gene id: 13616:MELK
uniprot id: F7FWS7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

13616:ARPC5L
gene id: 13616:ARPC5L
uniprot id: F6WN64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

13616:PTS
gene id: 13616:PTS
uniprot id: A0A5F8GKA0
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

13616:LOC100023867
gene id: 13616:LOC100023867
uniprot id: F7AFL4
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:ATP1B2
gene id: 13616:ATP1B2
uniprot id: F7FQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

13616:IFNK
gene id: 13616:IFNK
uniprot id: A8E6F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:SPI1
gene id: 13616:SPI1
uniprot id: A0A5F8G6A3
uniprot id: F6VQ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:KIAA1324L
gene id: 13616:KIAA1324L
uniprot id: F6V5K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

13616:TDP1
gene id: 13616:TDP1
uniprot id: F6PJT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

13616:LOC107648878
gene id: 13616:LOC107648878
uniprot id: A0A5F8GB82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:STX3
gene id: 13616:STX3
uniprot id: A0A5F8GG36
names: Similarity
messages: Belongs to the syntaxin family.

13616:GJB4
gene id: 13616:GJB4
uniprot id: F7E348
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:LOC100020048
gene id: 13616:LOC100020048
uniprot id: A0A5F8HD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MODO-UI
gene id: 13616:MODO-UI
uniprot id: C6ZIV2
names: Similarity
messages: Belongs to the MHC class I family.

13616:LOC100618756
gene id: 13616:LOC100618756
uniprot id: A0A5F8GPU1
names: Similarity
messages: Belongs to the intermediate filament family.

13616:C1QA
gene id: 13616:C1QA
uniprot id: A0A5F8GSF6
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

13616:LOC100016035
gene id: 13616:LOC100016035
uniprot id: F7CQE9
names: Similarity
messages: Belongs to the centrin family.

13616:MAP4K1
gene id: 13616:MAP4K1
uniprot id: F6YWC5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

13616:SPCS1
gene id: 13616:SPCS1
uniprot id: F6SRE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CNN2
gene id: 13616:CNN2
uniprot id: A0A5F8H774
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

13616:GPR17
gene id: 13616:GPR17
uniprot id: F6UCF6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:NCSTN
gene id: 13616:NCSTN
uniprot id: F7F9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

13616:DNA2
gene id: 13616:DNA2
uniprot id: A0A5F8GCX5
uniprot id: F6S4L6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

13616:CNKSR2
gene id: 13616:CNKSR2
uniprot id: F7CLK9
names: Similarity
messages: Belongs to the CNKSR family.

13616:CCT2
gene id: 13616:CCT2
uniprot id: F7F689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:KIAA0907
gene id: 13616:KIAA0907
uniprot id: F6UL87
names: Similarity
messages: Belongs to the KHDC4 family.

13616:NR1H4
gene id: 13616:NR1H4
uniprot id: A0A5F8HHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:IGFBP4
gene id: 13616:IGFBP4
uniprot id: F7ABV3
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:ST3GAL1
gene id: 13616:ST3GAL1
uniprot id: F7GHP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:BVES
gene id: 13616:BVES
uniprot id: F6ZWG8
names: Similarity
messages: Belongs to the popeye family.

13616:PSENEN
gene id: 13616:PSENEN
uniprot id: F6VQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

13616:CAMLG
gene id: 13616:CAMLG
uniprot id: A0A5F8H8M1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

13616:PHACTR3
gene id: 13616:PHACTR3
uniprot id: F6ZC64
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

13616:ARSK
gene id: 13616:ARSK
uniprot id: F7ESB2
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:CHST1
gene id: 13616:CHST1
uniprot id: F6Z900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

13616:LOC100013054
gene id: 13616:LOC100013054
uniprot id: F6Z242
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

13616:BRPF3
gene id: 13616:BRPF3
uniprot id: A0A5F8G9J0
uniprot id: F6UD32
names: Subcellular Location Annotation
messages: Nucleus

13616:TRMT11
gene id: 13616:TRMT11
uniprot id: A0A5F8HIK4
uniprot id: F7GFQ3
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

13616:IRX2
gene id: 13616:IRX2
uniprot id: F6R2X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:QSOX2
gene id: 13616:QSOX2
uniprot id: F7E0U9
names: Caution
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:IMP4
gene id: 13616:IMP4
uniprot id: F7GI18
names: Subcellular Location Annotation
messages: nucleolus

13616:LOC100012266
gene id: 13616:LOC100012266
uniprot id: A0A5F8GW64
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:MND1
gene id: 13616:MND1
uniprot id: F7D4R4
names: Subcellular Location Annotation
messages: Nucleus

13616:TMEM200B
gene id: 13616:TMEM200B
uniprot id: F7EN37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

13616:TFAP2B
gene id: 13616:TFAP2B
uniprot id: F7GKB8
names: Similarity
messages: Belongs to the AP-2 family.

13616:LOC100023806
gene id: 13616:LOC100023806
uniprot id: F6ZH23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TM4SF5
gene id: 13616:TM4SF5
uniprot id: F7DJD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:EFNA5
gene id: 13616:EFNA5
uniprot id: A0A5F8G2K2
uniprot id: A0A5F8HEI1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:POPDC3
gene id: 13616:POPDC3
uniprot id: F6ZWH6
names: Similarity
messages: Belongs to the popeye family.

13616:FIP1L1
gene id: 13616:FIP1L1
uniprot id: A0A5F8G5T5
uniprot id: A0A5F8GF49
uniprot id: F7E5Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

13616:YIF1B
gene id: 13616:YIF1B
uniprot id: F7BM72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

13616:CLDN20
gene id: 13616:CLDN20
uniprot id: F6SEP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:GFOD2
gene id: 13616:GFOD2
uniprot id: A0A5F8GEG8
uniprot id: F6VKR9
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

13616:LOC107649021
gene id: 13616:LOC107649021
uniprot id: A0A5F8HFL8
names: Function
messages: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

13616:AMOTL2
gene id: 13616:AMOTL2
uniprot id: F7B3K2
names: Similarity
messages: Belongs to the angiomotin family.

13616:PEX10
gene id: 13616:PEX10
uniprot id: F7ELT0
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

13616:LOC100618293
gene id: 13616:LOC100618293
uniprot id: F7BAF0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

13616:MTMR9
gene id: 13616:MTMR9
uniprot id: F7GCP6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:TNFSF12
gene id: 13616:TNFSF12
uniprot id: A0A5F8GKJ9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:SLC6A7
gene id: 13616:SLC6A7
uniprot id: F6XTS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:LONP1
gene id: 13616:LONP1
uniprot id: F7BZI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.
messages: Mitochondrion matrix

13616:ADGRG6
gene id: 13616:ADGRG6
uniprot id: A0A5F8GVE8
uniprot id: A0A5F8HJH7
uniprot id: F6VSG8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:HOPX
gene id: 13616:HOPX
uniprot id: A0A5F8GHL5
names: Subcellular Location Annotation
messages: Nucleus

13616:GLB1L2
gene id: 13616:GLB1L2
uniprot id: A0A5F8H6U6
uniprot id: F7F3M1
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

13616:LOC100026503
gene id: 13616:LOC100026503
uniprot id: A0A5F8GFZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

13616:FAM122B
gene id: 13616:FAM122B
uniprot id: A0A5F8G6Z8
uniprot id: F7BVR8
names: Similarity
messages: Belongs to the FAM122 family.

13616:PRPSAP2
gene id: 13616:PRPSAP2
uniprot id: F7BIR5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

13616:PFDN2
gene id: 13616:PFDN2
uniprot id: A0A5F8H854
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

13616:SERP1
gene id: 13616:SERP1
uniprot id: F6T2I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

13616:TMOD2
gene id: 13616:TMOD2
uniprot id: A0A5F8GAC4
names: Subcellular Location Annotation
messages: cytoskeleton

13616:ELOF1
gene id: 13616:ELOF1
uniprot id: F7F290
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

13616:XKRX
gene id: 13616:XKRX
uniprot id: F7CWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

13616:METTL3
gene id: 13616:METTL3
uniprot id: F7FEI2
names: Similarity
messages: Belongs to the MT-A70-like family.

13616:SCD
gene id: 13616:SCD
uniprot id: F7D550
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

13616:ADRB2
gene id: 13616:ADRB2
uniprot id: F7BW45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Membrane

13616:PPP1R12B
gene id: 13616:PPP1R12B
uniprot id: A0A5F8HE46
uniprot id: F6SBH5
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

13616:ENTPD7
gene id: 13616:ENTPD7
uniprot id: F7C8K3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:PHACTR1
gene id: 13616:PHACTR1
uniprot id: A0A5F8G831
uniprot id: A0A5F8GXK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

13616:FARSB
gene id: 13616:FARSB
uniprot id: F6XVT6
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

13616:IL17D
gene id: 13616:IL17D
uniprot id: F7DJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

13616:HEXIM1
gene id: 13616:HEXIM1
uniprot id: F7E876
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

13616:TMA16
gene id: 13616:TMA16
uniprot id: F7GEJ0
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

13616:LCA5L
gene id: 13616:LCA5L
uniprot id: A0A5F8GEC4
uniprot id: F6S6N9
names: Similarity
messages: Belongs to the LCA5 family.

13616:RAP2A
gene id: 13616:RAP2A
uniprot id: A0A5F8G780
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

13616:PMS2
gene id: 13616:PMS2
uniprot id: F7E4Y3
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

13616:BRF2
gene id: 13616:BRF2
uniprot id: F7BZ92
names: Similarity
messages: Belongs to the TFIIB family.

13616:PHOSPHO1
gene id: 13616:PHOSPHO1
uniprot id: A0A5F8HIA0
uniprot id: F7CE09
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

13616:AARS2
gene id: 13616:AARS2
uniprot id: A0A5F8H2U3
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

13616:LOC100030384
gene id: 13616:LOC100030384
uniprot id: F7F1Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103094249
gene id: 13616:LOC103094249
uniprot id: F7FQQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CDC6
gene id: 13616:CDC6
uniprot id: F7BMZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

13616:TMOD4
gene id: 13616:TMOD4
uniprot id: A0A5F8GVB1
names: Subcellular Location Annotation
messages: cytoskeleton

13616:FAM124A
gene id: 13616:FAM124A
uniprot id: F7G7F7
names: Similarity
messages: Belongs to the FAM124 family.

13616:NGF
gene id: 13616:NGF
uniprot id: F6TNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

13616:ZDHHC21
gene id: 13616:ZDHHC21
uniprot id: F7CG33
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:ACTN2
gene id: 13616:ACTN2
uniprot id: A0A5F8G362
uniprot id: F6YXB0
names: Similarity
messages: Belongs to the alpha-actinin family.

13616:NUDT12
gene id: 13616:NUDT12
uniprot id: F6XSU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

13616:SLC9A4
gene id: 13616:SLC9A4
uniprot id: F7EGW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

13616:DLL1
gene id: 13616:DLL1
uniprot id: F7CZU6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

13616:LOC100012021
gene id: 13616:LOC100012021
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:WASF2
gene id: 13616:WASF2
uniprot id: F7FLU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

13616:AJAP1
gene id: 13616:AJAP1
uniprot id: F7EYW1
uniprot id: K7E2T9
names: Subcellular Location Annotation
messages: Membrane

13616:GALNT9
gene id: 13616:GALNT9
uniprot id: F6XFH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:monDomV1R1273
gene id: 13616:monDomV1R1273
uniprot id: A0A5F8G2Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MAT2A
gene id: 13616:MAT2A
uniprot id: A0A5F8H250
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

13616:HIBCH
gene id: 13616:HIBCH
uniprot id: A0A5F8H1K6
uniprot id: F6QBJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

13616:TBX15
gene id: 13616:TBX15
uniprot id: F7D2N6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:C8H7orf55
gene id: 13616:C8H7orf55
uniprot id: F6WS80
names: Similarity
messages: Belongs to the FMC1 family.

13616:SLC25A24
gene id: 13616:SLC25A24
uniprot id: F6YHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:FA2H
gene id: 13616:FA2H
uniprot id: F6YP85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:SRSF4
gene id: 13616:SRSF4
uniprot id: K7E429
names: Similarity
messages: Belongs to the splicing factor SR family.

13616:PNCK
gene id: 13616:PNCK
uniprot id: F7DJS8
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:TOR1B
gene id: 13616:TOR1B
uniprot id: F6PH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

13616:TNFSF13B
gene id: 13616:TNFSF13B
uniprot id: F7ASI1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:CAPN5
gene id: 13616:CAPN5
uniprot id: A0A5F8G4P6
names: Similarity
messages: Belongs to the peptidase C2 family.

13616:MSTN
gene id: 13616:MSTN
uniprot id: F6QWE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

13616:TDO2
gene id: 13616:TDO2
uniprot id: F6S7Q9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CCSER2
gene id: 13616:CCSER2
uniprot id: A0A5F8GCG8
uniprot id: A0A5F8GHW6
names: Similarity
messages: Belongs to the CCSER family.

13616:ING2
gene id: 13616:ING2
uniprot id: F6XRF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:NRDC
gene id: 13616:NRDC
uniprot id: A0A5F8GWJ0
names: Similarity
messages: Belongs to the peptidase M16 family.

13616:TOR4A
gene id: 13616:TOR4A
uniprot id: F6WXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Membrane

13616:TFCP2L1
gene id: 13616:TFCP2L1
uniprot id: F6SYN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

13616:G6PC3
gene id: 13616:G6PC3
uniprot id: F7G6N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

13616:FABP7
gene id: 13616:FABP7
uniprot id: F7ELF5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:GANAB
gene id: 13616:GANAB
uniprot id: A0A5F8GFQ7
uniprot id: F7EB75
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

13616:monDomV1R1225
gene id: 13616:monDomV1R1225
uniprot id: F7BT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100028987
gene id: 13616:LOC100028987
uniprot id: A0A5F8GVG2
uniprot id: F7DGL7
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

13616:IL6ST
gene id: 13616:IL6ST
uniprot id: F6VD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

13616:PRLR
gene id: 13616:PRLR
uniprot id: F7F6E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

13616:AMFR
gene id: 13616:AMFR
uniprot id: A0A5F8GEK6
uniprot id: F7DTS8
names: Subcellular Location Annotation
messages: Membrane

13616:VN2R543
gene id: 13616:VN2R543
uniprot id: F7EKZ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100617961
gene id: 13616:LOC100617961
uniprot id: F7BCQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:ARHGDIG
gene id: 13616:ARHGDIG
uniprot id: F7G770
names: Similarity
messages: Belongs to the Rho GDI family.

13616:RPL6
gene id: 13616:RPL6
uniprot id: F6PIV8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

13616:SDC2
gene id: 13616:SDC2
uniprot id: F6PWB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

13616:VMA21
gene id: 13616:VMA21
uniprot id: A0A5F8HG12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

13616:KCNG1
gene id: 13616:KCNG1
uniprot id: F7F6U0
names: Subcellular Location Annotation
messages: Membrane

13616:SNRNP27
gene id: 13616:SNRNP27
uniprot id: F6S5R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

13616:CLDN14
gene id: 13616:CLDN14
uniprot id: F6Z9T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:SLC34A1
gene id: 13616:SLC34A1
uniprot id: F6VRE2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

13616:ANP32B
gene id: 13616:ANP32B
uniprot id: F6T049
names: Similarity
messages: Belongs to the ANP32 family.

13616:CAMSAP2
gene id: 13616:CAMSAP2
uniprot id: A0A5F8HIU6
uniprot id: F6Z1A1
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

13616:TMEM116
gene id: 13616:TMEM116
uniprot id: F7E2L0
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100015895
gene id: 13616:LOC100015895
uniprot id: F7F9P8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:MAPK4
gene id: 13616:MAPK4
uniprot id: F6YVG7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

13616:KHDRBS3
gene id: 13616:KHDRBS3
uniprot id: F7ESF8
names: Similarity
messages: Belongs to the KHDRBS family.

13616:C5H4orf27
gene id: 13616:C5H4orf27
uniprot id: A0A5F8H686
uniprot id: F6Q138
names: Similarity
messages: Belongs to the HPF1 family.

13616:POLL
gene id: 13616:POLL
uniprot id: A0A5F8H1U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

13616:USP20
gene id: 13616:USP20
uniprot id: F6PSB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

13616:ZDHHC6
gene id: 13616:ZDHHC6
uniprot id: F6ST88
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:ACTC1
gene id: 13616:ACTC1
uniprot id: F7GL73
names: Similarity
messages: Belongs to the actin family.

13616:LOC100618857
gene id: 13616:LOC100618857
uniprot id: F6YMF4
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:FAM65C
gene id: 13616:FAM65C
uniprot id: A0A5F8HHW7
uniprot id: F7FKL6
names: Similarity
messages: Belongs to the RIPOR family.

13616:KEG11 p09
gene id: 13616:KEG11_p09
uniprot id: Q65CI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

13616:PITHD1
gene id: 13616:PITHD1
uniprot id: F7D6T5
names: Similarity
messages: Belongs to the PITHD1 family.

13616:ISOC1
gene id: 13616:ISOC1
uniprot id: F7F185
names: Similarity
messages: Belongs to the isochorismatase family.

13616:VN2R639
gene id: 13616:VN2R639
uniprot id: A0A5F8H235
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TGFA
gene id: 13616:TGFA
uniprot id: F6QBL8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MLF2
gene id: 13616:MLF2
uniprot id: F7FF99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

13616:MFAP5
gene id: 13616:MFAP5
uniprot id: A0A5F8HI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

13616:LOC100013532
gene id: 13616:LOC100013532
uniprot id: F6YPU1
names: Similarity
messages: Belongs to the intermediate filament family.

13616:monDomV1R1246
gene id: 13616:monDomV1R1246
uniprot id: A0A5F8H6U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RABGGTA
gene id: 13616:RABGGTA
uniprot id: F6WVF8
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

13616:ALDOC
gene id: 13616:ALDOC
uniprot id: F6Q8Q1
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

13616:LOC100018060
gene id: 13616:LOC100018060
uniprot id: F6V845
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:INO80D
gene id: 13616:INO80D
uniprot id: A0A5F8HGM7
uniprot id: F6ZHX1
names: Subcellular Location Annotation
messages: Nucleus

13616:UCN
gene id: 13616:UCN
uniprot id: F7AVH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

13616:STK40
gene id: 13616:STK40
uniprot id: F6ZXC1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

13616:SH3PXD2A
gene id: 13616:SH3PXD2A
uniprot id: A0A5F8HGP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

13616:LOC100017021
gene id: 13616:LOC100017021
uniprot id: F7GKU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EML3
gene id: 13616:EML3
uniprot id: A0A5F8H5B7
names: Similarity
messages: Belongs to the WD repeat EMAP family.

13616:POLR2D
gene id: 13616:POLR2D
uniprot id: F7B1V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

13616:C6H16orf58
gene id: 13616:C6H16orf58
uniprot id: F7A2S4
names: Similarity
messages: Belongs to the RUS1 family.

13616:NDUFS2
gene id: 13616:NDUFS2
uniprot id: F7EQ50
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

13616:BMP3
gene id: 13616:BMP3
uniprot id: F6YKG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

13616:EIF4EBP2
gene id: 13616:EIF4EBP2
uniprot id: F7CYK5
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

13616:LOC100030871
gene id: 13616:LOC100030871
uniprot id: A0A5F8GQH4
uniprot id: A0A5F8GRM0
names: Subcellular Location Annotation
messages: Cytoplasm

13616:CWF19L2
gene id: 13616:CWF19L2
uniprot id: F7DN63
names: Similarity
messages: Belongs to the CWF19 family.

13616:LOC100619033
gene id: 13616:LOC100619033
uniprot id: F7ENP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:LOC100013669
gene id: 13616:LOC100013669
uniprot id: A0A5F8GBB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:RNF182
gene id: 13616:RNF182
uniprot id: F6Q9S1
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

13616:CAPRIN1
gene id: 13616:CAPRIN1
uniprot id: A0A5F8G6E4
names: Similarity
messages: Belongs to the caprin family.

13616:LOC100014394
gene id: 13616:LOC100014394
uniprot id: F7CQT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

13616:LOC100619044
gene id: 13616:LOC100619044
uniprot id: A0A5F8HF59
names: Similarity
messages: Belongs to the intermediate filament family.

13616:ATG4B
gene id: 13616:ATG4B
uniprot id: A0A5F8GW90
uniprot id: F6PG58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: autophagosome
messages: cytosol

13616:IL6
gene id: 13616:IL6
uniprot id: F7CIZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

13616:DCST2
gene id: 13616:DCST2
uniprot id: A0A5F8GX29
uniprot id: F6U3F5
names: Subcellular Location Annotation
messages: Membrane

13616:MAS1
gene id: 13616:MAS1
uniprot id: F6ZNI5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100028620
gene id: 13616:LOC100028620
uniprot id: F7FSV0
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:RBP4
gene id: 13616:RBP4
uniprot id: K7E0U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

13616:EIF5A
gene id: 13616:EIF5A
uniprot id: F7G3Z4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

13616:SASS6
gene id: 13616:SASS6
uniprot id: F7FAN2
names: Subcellular Location Annotation
messages: centrosome

13616:PEX3
gene id: 13616:PEX3
uniprot id: F6T4F5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

13616:HS3ST5
gene id: 13616:HS3ST5
uniprot id: A0A5F8G6D9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:LOC103094375
gene id: 13616:LOC103094375
uniprot id: A0A5F8HIJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

13616:GBAS
gene id: 13616:GBAS
uniprot id: F6ZWX7
names: Similarity
messages: Belongs to the NipSnap family.

13616:LOC107650288
gene id: 13616:LOC107650288
uniprot id: A0A5F8HF64
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

13616:STRA6
gene id: 13616:STRA6
uniprot id: A0A5F8GED7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:MAN2B2
gene id: 13616:MAN2B2
uniprot id: F7B602
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

13616:DCP2
gene id: 13616:DCP2
uniprot id: F7FEL1
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

13616:RPS27L
gene id: 13616:RPS27L
uniprot id: A0A5F8H0P7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

13616:monDomV1R1229
gene id: 13616:monDomV1R1229
uniprot id: A0A5F8GBT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100019436
gene id: 13616:LOC100019436
uniprot id: F6VFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100025543
gene id: 13616:LOC100025543
uniprot id: F7CGC3
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse
messages: axon
messages: dendrite

13616:EFNA1
gene id: 13616:EFNA1
uniprot id: F6UJM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100020571
gene id: 13616:LOC100020571
uniprot id: K7E4Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:TTC27
gene id: 13616:TTC27
uniprot id: A0A5F8HEM5
names: Similarity
messages: Belongs to the TTC27 family.

13616:LOC100025990
gene id: 13616:LOC100025990
uniprot id: F6ZD60
names: Similarity
messages: Belongs to the MHC class II family.

13616:DAZL
gene id: 13616:DAZL
uniprot id: A0A5F8GPT9
uniprot id: F6ZCR3
uniprot id: K7E074
names: Subcellular Location Annotation
messages: Cytoplasm

13616:EMC2
gene id: 13616:EMC2
uniprot id: F7A6D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

13616:LOC100032472
gene id: 13616:LOC100032472
uniprot id: F6PGR8
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

13616:ENTPD8
gene id: 13616:ENTPD8
uniprot id: F6WHR6
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:C5AR1
gene id: 13616:C5AR1
uniprot id: F7CUC2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:UST
gene id: 13616:UST
uniprot id: F6R231
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

13616:XPO5
gene id: 13616:XPO5
uniprot id: F7G0D4
names: Subcellular Location Annotation
messages: Cytoplasm

13616:TAGLN2
gene id: 13616:TAGLN2
uniprot id: A0A5F8GEV2
names: Similarity
messages: Belongs to the calponin family.

13616:NR4A3
gene id: 13616:NR4A3
uniprot id: F6VYB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:LOC100013494
gene id: 13616:LOC100013494
uniprot id: F6YMC4
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100013319
gene id: 13616:LOC100013319
uniprot id: A0A5F8HEY3
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:ABCB6
gene id: 13616:ABCB6
uniprot id: F6XYD4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

13616:LOC100021887
gene id: 13616:LOC100021887
uniprot id: F7AI56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SNX7
gene id: 13616:SNX7
uniprot id: F7DSA7
names: Similarity
messages: Belongs to the sorting nexin family.

13616:LOC100013604
gene id: 13616:LOC100013604
uniprot id: F6ZDD9
names: Similarity
messages: Belongs to the intermediate filament family.

13616:ATP8B1
gene id: 13616:ATP8B1
uniprot id: F7AQI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:MED29
gene id: 13616:MED29
uniprot id: F7F8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

13616:GHR
gene id: 13616:GHR
uniprot id: F7C0F5
uniprot id: Q9N0Y7
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

13616:ORC4
gene id: 13616:ORC4
uniprot id: F7DDI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

13616:B4GALT6
gene id: 13616:B4GALT6
uniprot id: A0A5F8GIY1
uniprot id: A0A5F8GVZ2
uniprot id: A0A5F8HAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:HOXA11
gene id: 13616:HOXA11
uniprot id: F6USH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:LOC100028638
gene id: 13616:LOC100028638
uniprot id: F7FSN0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

13616:TOMM20L
gene id: 13616:TOMM20L
uniprot id: F6ZG99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

13616:XRCC4
gene id: 13616:XRCC4
uniprot id: A0A5F8HJP0
uniprot id: F6ZI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

13616:TOMM20
gene id: 13616:TOMM20
uniprot id: F7GEZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

13616:LYPLA1
gene id: 13616:LYPLA1
uniprot id: A0A5F8HAE2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

13616:LOC100030294
gene id: 13616:LOC100030294
uniprot id: F7CT20
names: Subcellular Location Annotation
messages: Membrane

13616:NOSIP
gene id: 13616:NOSIP
uniprot id: F6UWQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

13616:PHC3
gene id: 13616:PHC3
uniprot id: F7FZ58
names: Subcellular Location Annotation
messages: Nucleus

13616:GABRQ
gene id: 13616:GABRQ
uniprot id: A0A5F8H1S9
uniprot id: F6WX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:AMH
gene id: 13616:AMH
uniprot id: F6TR95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

13616:RPAP2
gene id: 13616:RPAP2
uniprot id: A0A5F8GIQ0
uniprot id: F7A3A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

13616:SCARA5
gene id: 13616:SCARA5
uniprot id: A0A5F8GPZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

13616:LOC100026382
gene id: 13616:LOC100026382
uniprot id: F7EED9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

13616:LOC100020628
gene id: 13616:LOC100020628
uniprot id: F6S9M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LRRC8E
gene id: 13616:LRRC8E
uniprot id: F7CGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

13616:DGUOK
gene id: 13616:DGUOK
uniprot id: A0A5F8HFH0
names: Similarity
messages: Belongs to the DCK/DGK family.

13616:TUBGCP3
gene id: 13616:TUBGCP3
uniprot id: F6UBF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

13616:LOC103098663
gene id: 13616:LOC103098663
uniprot id: F6YSK2
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

13616:LOC100016274
gene id: 13616:LOC100016274
uniprot id: F6Z5B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:AMDHD1
gene id: 13616:AMDHD1
uniprot id: F6Z9Z3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

13616:HNRNPAB
gene id: 13616:HNRNPAB
uniprot id: A0A5F8GQ11
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:TNKS2
gene id: 13616:TNKS2
uniprot id: F7CDC2
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:NFASC
gene id: 13616:NFASC
uniprot id: A0A5F8HEG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

13616:MIC-like
gene id: 13616:MIC-like
uniprot id: D7URV4
names: Similarity
messages: Belongs to the MHC class I family.

13616:KIF27
gene id: 13616:KIF27
uniprot id: F7FRJ7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:FSCN2
gene id: 13616:FSCN2
uniprot id: F7DHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

13616:CHD2
gene id: 13616:CHD2
uniprot id: F6ZM50
names: Subcellular Location Annotation
messages: Nucleus

13616:UBL4B
gene id: 13616:UBL4B
uniprot id: Q19KS6
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolution.

13616:EPHA5
gene id: 13616:EPHA5
uniprot id: A0A5F8G8S7
uniprot id: F7ANR2
names: Subcellular Location Annotation
messages: Membrane

13616:DDX59
gene id: 13616:DDX59
uniprot id: A0A5F8GYP3
uniprot id: A0A5F8HA09
uniprot id: F6ZPD5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

13616:LTBP1
gene id: 13616:LTBP1
uniprot id: A0A5F8GLL6
uniprot id: F6SLS5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:MAPRE1
gene id: 13616:MAPRE1
uniprot id: F6RY10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

13616:SRFBP1
gene id: 13616:SRFBP1
uniprot id: F6QFG0
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

13616:FAXC
gene id: 13616:FAXC
uniprot id: F7F1Y6
names: Similarity
messages: Belongs to the FAX family.

13616:LOC100033268
gene id: 13616:LOC100033268
uniprot id: A0A5F8GZI5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:SPOP
gene id: 13616:SPOP
uniprot id: A0A5F8GQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

13616:monDomV1R1262
gene id: 13616:monDomV1R1262
uniprot id: A0A5F8HJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC29A3
gene id: 13616:SLC29A3
uniprot id: F6PVB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

13616:TARS
gene id: 13616:TARS
uniprot id: F7BZE2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

13616:SCAMP5
gene id: 13616:SCAMP5
uniprot id: A0A5F8GNP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

13616:LOC100030876
gene id: 13616:LOC100030876
uniprot id: A0A5F8H421
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:NIPBL
gene id: 13616:NIPBL
uniprot id: F7FKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

13616:ITGB4
gene id: 13616:ITGB4
uniprot id: A0A5F8G3D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

13616:CERS2
gene id: 13616:CERS2
uniprot id: F6YYM6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:RORC
gene id: 13616:RORC
uniprot id: A0A5F8G5E3
uniprot id: F6R6L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:BACE2
gene id: 13616:BACE2
uniprot id: F6SNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane

13616:FTO
gene id: 13616:FTO
uniprot id: A0A5F8GF52
uniprot id: A0A5F8GKL6
uniprot id: A0A5F8HA43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.
messages: Cytoplasm
messages: Nucleus speckle

13616:ENTPD3
gene id: 13616:ENTPD3
uniprot id: F6TMK1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:SHH
gene id: 13616:SHH
uniprot id: D5KSE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hedgehog family.
messages: Membrane

13616:C7H2orf49
gene id: 13616:C7H2orf49
uniprot id: F7B9F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

13616:FAM3A
gene id: 13616:FAM3A
uniprot id: F7BPN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

13616:SLC35A2
gene id: 13616:SLC35A2
uniprot id: F6TCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

13616:CENPI
gene id: 13616:CENPI
uniprot id: F7DFD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

13616:FBP1
gene id: 13616:FBP1
uniprot id: A0A5F8HJ19
names: Similarity
messages: Belongs to the FBPase class 1 family.

13616:KCNA1
gene id: 13616:KCNA1
uniprot id: F7EBT4
names: Subcellular Location Annotation
messages: Membrane

13616:KDM3B
gene id: 13616:KDM3B
uniprot id: F7DHY8
names: Subcellular Location Annotation
messages: Nucleus

13616:DBNDD2
gene id: 13616:DBNDD2
uniprot id: F7G8N2
names: Similarity
messages: Belongs to the dysbindin family.

13616:SNX32
gene id: 13616:SNX32
uniprot id: F6ZNH6
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

13616:CHMP4C
gene id: 13616:CHMP4C
uniprot id: F7FS96
names: Similarity
messages: Belongs to the SNF7 family.

13616:FAM149B1
gene id: 13616:FAM149B1
uniprot id: A0A5F8H0L5
names: Similarity
messages: Belongs to the FAM149 family.

13616:AP3B1
gene id: 13616:AP3B1
uniprot id: A0A5F8GK69
uniprot id: F6X3Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

13616:TRIM72
gene id: 13616:TRIM72
uniprot id: F7F5W4
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: sarcolemma

13616:SLC9C2
gene id: 13616:SLC9C2
uniprot id: A0A5F8GF06
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

13616:POLR2M
gene id: 13616:POLR2M
uniprot id: F7GET9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

13616:SLC25A37
gene id: 13616:SLC25A37
uniprot id: F7G676
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:BRCA1
gene id: 13616:BRCA1
uniprot id: F7CFT5
uniprot id: Q52P67
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus

13616:UCP1
gene id: 13616:UCP1
uniprot id: F6X9Y8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

13616:POLR2A
gene id: 13616:POLR2A
uniprot id: F6XTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

13616:CPO
gene id: 13616:CPO
uniprot id: F7EZD6
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:EVA1B
gene id: 13616:EVA1B
uniprot id: F6ZXB4
names: Similarity
messages: Belongs to the EVA1 family.

13616:CORIN
gene id: 13616:CORIN
uniprot id: F6ZAT4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PPP1R21
gene id: 13616:PPP1R21
uniprot id: A0A5F8G3R8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

13616:PRKG2
gene id: 13616:PRKG2
uniprot id: F6YKH9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

13616:CPSF3L
gene id: 13616:CPSF3L
uniprot id: F7CAF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

13616:PROM1
gene id: 13616:PROM1
uniprot id: A0A5F8GWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

13616:LOC100017328
gene id: 13616:LOC100017328
uniprot id: A0A5F8HF86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:IL17RB
gene id: 13616:IL17RB
uniprot id: A0A5F8G9B2
uniprot id: F6Q0J4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100022107
gene id: 13616:LOC100022107
uniprot id: F6PZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100018705
gene id: 13616:LOC100018705
uniprot id: A0A5F8GFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:THAP1
gene id: 13616:THAP1
uniprot id: F6XLQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

13616:CSNK1A1
gene id: 13616:CSNK1A1
uniprot id: A0A5F8HJM6
uniprot id: F6R812
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:CEP19
gene id: 13616:CEP19
uniprot id: F7CUD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

13616:ANO4
gene id: 13616:ANO4
uniprot id: A0A5F8G4Q0
uniprot id: A0A5F8HAA1
uniprot id: F7FL71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ASAH1
gene id: 13616:ASAH1
uniprot id: F7BKX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

13616:TM4SF20
gene id: 13616:TM4SF20
uniprot id: F6UGK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:TMTC1
gene id: 13616:TMTC1
uniprot id: A0A5F8GKU3
uniprot id: F6UAD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

13616:COMP
gene id: 13616:COMP
uniprot id: F7AZT2
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:C2H6orf89
gene id: 13616:C2H6orf89
uniprot id: A0A5F8GHL3
uniprot id: F7F8J5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100027703
gene id: 13616:LOC100027703
uniprot id: A0A5F8HI21
uniprot id: F7DDL6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

13616:RRP1
gene id: 13616:RRP1
uniprot id: A0A5F8HFN1
names: Similarity
messages: Belongs to the RRP1 family.

13616:CHFR
gene id: 13616:CHFR
uniprot id: F6TMI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

13616:TRIM45
gene id: 13616:TRIM45
uniprot id: A0A5F8GEA8
uniprot id: A0A5F8H696
uniprot id: F7E8F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

13616:CREB1
gene id: 13616:CREB1
uniprot id: A0A5F8GN53
uniprot id: A0A5F8HIA8
uniprot id: F7FD05
names: Subcellular Location Annotation
messages: Nucleus

13616:DDX52
gene id: 13616:DDX52
uniprot id: F7BVL7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

13616:monDomV1R1261
gene id: 13616:monDomV1R1261
uniprot id: A0A5F8H6Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FXR1
gene id: 13616:FXR1
uniprot id: A0A5F8G660
names: Similarity
messages: Belongs to the FMR1 family.

13616:PDRG1
gene id: 13616:PDRG1
uniprot id: F6WAE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

13616:HINT2
gene id: 13616:HINT2
uniprot id: F6RG00
names: Similarity
messages: Belongs to the HINT family.

13616:NRN1
gene id: 13616:NRN1
uniprot id: A0A5F8GMV9
names: Similarity
messages: Belongs to the neuritin family.

13616:LOC100018981
gene id: 13616:LOC100018981
uniprot id: F6U150
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100024568
gene id: 13616:LOC100024568
uniprot id: F6PJ15
names: Similarity
messages: Belongs to the serpin family.

13616:PPP1R3C
gene id: 13616:PPP1R3C
uniprot id: F7CCR6
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

13616:SMC3
gene id: 13616:SMC3
uniprot id: A0A5F8G848
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

13616:ANKRD13B
gene id: 13616:ANKRD13B
uniprot id: F6REP0
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

13616:CDC14B
gene id: 13616:CDC14B
uniprot id: F6XN43
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

13616:CA9
gene id: 13616:CA9
uniprot id: F7CQP4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:RAB3IP
gene id: 13616:RAB3IP
uniprot id: F7F670
names: Similarity
messages: Belongs to the SEC2 family.

13616:NOTUM
gene id: 13616:NOTUM
uniprot id: F6WU00
names: Similarity
messages: Belongs to the pectinacetylesterase family. Notum subfamily.

13616:HHIP
gene id: 13616:HHIP
uniprot id: A0A5F8G8G3
uniprot id: F6UT79
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:APOOL
gene id: 13616:APOOL
uniprot id: F6V4X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

13616:GUCA2A
gene id: 13616:GUCA2A
uniprot id: F6WWL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

13616:DRD2
gene id: 13616:DRD2
uniprot id: F6TRD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

13616:CEMIP
gene id: 13616:CEMIP
uniprot id: F6SZF3
names: Similarity
messages: Belongs to the CEMIP family.

13616:FGF20
gene id: 13616:FGF20
uniprot id: F7AXM6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:TPRKB
gene id: 13616:TPRKB
uniprot id: F6V6G9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

13616:MESDC2
gene id: 13616:MESDC2
uniprot id: F6SZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

13616:C9
gene id: 13616:C9
uniprot id: F7G7P1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

13616:NEK8
gene id: 13616:NEK8
uniprot id: A0A5F8GJF8
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

13616:PIPOX
gene id: 13616:PIPOX
uniprot id: A0A5F8H7Q1
names: Similarity
messages: Belongs to the MSOX/MTOX family.

13616:ATXN3
gene id: 13616:ATXN3
uniprot id: A0A5F8G217
uniprot id: A0A5F8HC13
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100024051
gene id: 13616:LOC100024051
uniprot id: F7EHY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RTN4
gene id: 13616:RTN4
uniprot id: A0A5F8GRQ3
uniprot id: F6T5Z0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOX
gene id: 13616:LOX
uniprot id: F7F939
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

13616:SOX14
gene id: 13616:SOX14
uniprot id: F6XNT3
names: Subcellular Location Annotation
messages: Nucleus

13616:GNAL
gene id: 13616:GNAL
uniprot id: F7CB49
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

13616:LOC100013113
gene id: 13616:LOC100013113
uniprot id: A0A5F8GAM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:LOC100018962
gene id: 13616:LOC100018962
uniprot id: F6V6L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LAMTOR3
gene id: 13616:LAMTOR3
uniprot id: F7DKI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

13616:IFN2
gene id: 13616:IFN2
uniprot id: A8E6E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:KCNMB3
gene id: 13616:KCNMB3
uniprot id: F7G3H8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

13616:AGPAT1
gene id: 13616:AGPAT1
uniprot id: A0A5F8G731
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

13616:LOC100013358
gene id: 13616:LOC100013358
uniprot id: F6X5U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ETF1
gene id: 13616:ETF1
uniprot id: F7FU88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

13616:GALR1
gene id: 13616:GALR1
uniprot id: F6YFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:GPX8
gene id: 13616:GPX8
uniprot id: A0A5F8H4R1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

13616:SDCCAG3
gene id: 13616:SDCCAG3
uniprot id: F7BSG6
names: Similarity
messages: Belongs to the ENTR1 family.

13616:LOC103094304
gene id: 13616:LOC103094304
uniprot id: A0A5F8GLC9
names: Subcellular Location Annotation
messages: Nucleus

13616:HMBS
gene id: 13616:HMBS
uniprot id: F6ZKA2
names: Similarity
messages: Belongs to the HMBS family.

13616:LOC100023336
gene id: 13616:LOC100023336
uniprot id: K7E6E7
names: Similarity
messages: Belongs to the actin family.

13616:MKS1
gene id: 13616:MKS1
uniprot id: F6YN29
names: Subcellular Location Annotation
messages: cilium basal body

13616:TSPAN33
gene id: 13616:TSPAN33
uniprot id: F7DNN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:TCP1
gene id: 13616:TCP1
uniprot id: Q9XT06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with GBA1 (By similarity). Interacts with DLEC1 (By similarity).
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: centrosome
messages: cytosol

13616:TMEM201
gene id: 13616:TMEM201
uniprot id: A0A5F8GN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

13616:TOP3A
gene id: 13616:TOP3A
uniprot id: F6QP60
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

13616:HMGB3
gene id: 13616:HMGB3
uniprot id: C7E652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

13616:YWHAZ
gene id: 13616:YWHAZ
uniprot id: F7BS95
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:LOC100027041
gene id: 13616:LOC100027041
uniprot id: F7AWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

13616:LOC100014688
gene id: 13616:LOC100014688
uniprot id: F7CUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ELAVL2
gene id: 13616:ELAVL2
uniprot id: A0A5F8G6K3
names: Similarity
messages: Belongs to the RRM elav family.

13616:CMTM6
gene id: 13616:CMTM6
uniprot id: F7BVQ6
names: Subcellular Location Annotation
messages: Membrane

13616:PAH
gene id: 13616:PAH
uniprot id: A0A5F8GPC2
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

13616:LOC100028573
gene id: 13616:LOC100028573
uniprot id: F6V606
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PRKCH
gene id: 13616:PRKCH
uniprot id: F6PWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

13616:CHDH
gene id: 13616:CHDH
uniprot id: F6PZX9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

13616:COPG1
gene id: 13616:COPG1
uniprot id: F7F307
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

13616:ARSI
gene id: 13616:ARSI
uniprot id: F6RZZ5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:FAM76A
gene id: 13616:FAM76A
uniprot id: A0A5F8G818
uniprot id: A0A5F8GV49
names: Similarity
messages: Belongs to the FAM76 family.

13616:MURC
gene id: 13616:MURC
uniprot id: A0A5F8HHK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

13616:NAF1
gene id: 13616:NAF1
uniprot id: K7E2M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

13616:NOTCH4
gene id: 13616:NOTCH4
uniprot id: F6SDD3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

13616:GUCY1B3
gene id: 13616:GUCY1B3
uniprot id: F7AMU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

13616:LOC100027227
gene id: 13616:LOC100027227
uniprot id: F7B0S5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

13616:EMC4
gene id: 13616:EMC4
uniprot id: F6SR81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:DFNB59
gene id: 13616:DFNB59
uniprot id: F7EF78
names: Similarity
messages: Belongs to the gasdermin family.

13616:MRPL2
gene id: 13616:MRPL2
uniprot id: F7FNZ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

13616:SLC24A5
gene id: 13616:SLC24A5
uniprot id: F6YH24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

13616:SMG1
gene id: 13616:SMG1
uniprot id: F7F0R6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

13616:PAN3
gene id: 13616:PAN3
uniprot id: A0A5F8GIE9
uniprot id: F7FR09
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

13616:FEV
gene id: 13616:FEV
uniprot id: F6WXL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:PLAG1
gene id: 13616:PLAG1
uniprot id: A0A5F8GKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

13616:PDLIM3
gene id: 13616:PDLIM3
uniprot id: A0A5F8GHU1
uniprot id: A0A5F8HEM6
names: Subcellular Location Annotation
messages: Z line

13616:ATP6V1B2
gene id: 13616:ATP6V1B2
uniprot id: F6RX69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

13616:SPSB1
gene id: 13616:SPSB1
uniprot id: F7EE24
names: Similarity
messages: Belongs to the SPSB family.

13616:CACNB2
gene id: 13616:CACNB2
uniprot id: A0A5F8GQ07
uniprot id: A0A5F8H7D7
uniprot id: F6REU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

13616:LOC100031528
gene id: 13616:LOC100031528
uniprot id: F7C2Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PMEPA1
gene id: 13616:PMEPA1
uniprot id: F7EQ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

13616:LOC100618856
gene id: 13616:LOC100618856
uniprot id: A0A5F8HF11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DDAH1
gene id: 13616:DDAH1
uniprot id: A0A5F8G8Q3
uniprot id: A0A5F8H3U8
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

13616:LOC100028963
gene id: 13616:LOC100028963
uniprot id: F7BJB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100013070
gene id: 13616:LOC100013070
uniprot id: F7C2H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100031231
gene id: 13616:LOC100031231
uniprot id: A0A5F8G8P4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:ECE1
gene id: 13616:ECE1
uniprot id: F7EYY6
names: Function
messages: Converts big endothelin-1 to endothelin-1.

13616:PFN1
gene id: 13616:PFN1
uniprot id: F7DMM7
names: Similarity
messages: Belongs to the profilin family.

13616:LOC100018677
gene id: 13616:LOC100018677
uniprot id: A0A5F8GLC4
uniprot id: F6WWR9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:ZDHHC4
gene id: 13616:ZDHHC4
uniprot id: A0A5F8HJH6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:EOGT
gene id: 13616:EOGT
uniprot id: F7DWT3
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

13616:LOC100015103
gene id: 13616:LOC100015103
uniprot id: A0A5F8G8R6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

13616:LIN7C
gene id: 13616:LIN7C
uniprot id: F7FZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

13616:GAPDHS
gene id: 13616:GAPDHS
uniprot id: F6VBR8
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

13616:LOC100020065
gene id: 13616:LOC100020065
uniprot id: F7C6I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:MAPK10
gene id: 13616:MAPK10
uniprot id: A0A5F8G214
uniprot id: A0A5F8GE43
uniprot id: F6ZA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

13616:MMP13
gene id: 13616:MMP13
uniprot id: F6SS23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

13616:SLC25A39
gene id: 13616:SLC25A39
uniprot id: F6QCC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

13616:GABRA1
gene id: 13616:GABRA1
uniprot id: F7EUF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:NAGK
gene id: 13616:NAGK
uniprot id: F6SQY9
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

13616:FAM26F
gene id: 13616:FAM26F
uniprot id: F6Z8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:SLC17A9
gene id: 13616:SLC17A9
uniprot id: F6R209
names: Subcellular Location Annotation
messages: Membrane

13616:REEP4
gene id: 13616:REEP4
uniprot id: A0A5F8H3E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

13616:FAM161B
gene id: 13616:FAM161B
uniprot id: F7AK18
names: Similarity
messages: Belongs to the FAM161 family.

13616:MEOX1
gene id: 13616:MEOX1
uniprot id: F7BW00
names: Subcellular Location Annotation
messages: Nucleus

13616:CDC42
gene id: 13616:CDC42
uniprot id: A0A5F8GY66
uniprot id: F7A567
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

13616:EXOC6
gene id: 13616:EXOC6
uniprot id: A0A5F8G7R6
uniprot id: F7EZ69
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

13616:STRN
gene id: 13616:STRN
uniprot id: A0A5F8H540
uniprot id: F6WH28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

13616:DUS3L
gene id: 13616:DUS3L
uniprot id: F7FWB8
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

13616:GTPBP4
gene id: 13616:GTPBP4
uniprot id: F6TMC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

13616:SARS
gene id: 13616:SARS
uniprot id: F6YEX7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

13616:PREB
gene id: 13616:PREB
uniprot id: F7B5V1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

13616:SERPINB7
gene id: 13616:SERPINB7
uniprot id: F7CGZ0
names: Similarity
messages: Belongs to the serpin family.

13616:LOC100012064
gene id: 13616:LOC100012064
uniprot id: K7E2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:monDomV1R1204
gene id: 13616:monDomV1R1204
uniprot id: A0A5F8GU28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CHPF2
gene id: 13616:CHPF2
uniprot id: F6SCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

13616:EMX2
gene id: 13616:EMX2
uniprot id: F7CPI5
names: Subcellular Location Annotation
messages: Nucleus

13616:MANF
gene id: 13616:MANF
uniprot id: F7EGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

13616:KEAP1
gene id: 13616:KEAP1
uniprot id: F6QE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100024753
gene id: 13616:LOC100024753
uniprot id: A0A5F8H0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ANTXRL
gene id: 13616:ANTXRL
uniprot id: F6W852
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

13616:LOC100020439
gene id: 13616:LOC100020439
uniprot id: F6TUR3
names: Similarity
messages: Belongs to the actin family.

13616:POLR2H
gene id: 13616:POLR2H
uniprot id: A0A5F8G371
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

13616:ALKBH5
gene id: 13616:ALKBH5
uniprot id: F6XQJ4
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus speckle

13616:TFB1M
gene id: 13616:TFB1M
uniprot id: A0A5F8H1J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

13616:GNB1
gene id: 13616:GNB1
uniprot id: F6PVT7
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

13616:GPR87
gene id: 13616:GPR87
uniprot id: F7GEB2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:VN2R597
gene id: 13616:VN2R597
uniprot id: F7GHA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RBP1
gene id: 13616:RBP1
uniprot id: F7BQ15
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:CAPN9
gene id: 13616:CAPN9
uniprot id: A0A5F8HHT2
names: Similarity
messages: Belongs to the peptidase C2 family.

13616:MAK16
gene id: 13616:MAK16
uniprot id: F7DL52
names: Similarity
messages: Belongs to the MAK16 family.

13616:SLC12A6
gene id: 13616:SLC12A6
uniprot id: A0A5F8GEB6
uniprot id: F6X0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:RIMKLB
gene id: 13616:RIMKLB
uniprot id: F7B7U4
names: Similarity
messages: Belongs to the RimK family.

13616:FSHB
gene id: 13616:FSHB
uniprot id: Q95J82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

13616:RECQL4
gene id: 13616:RECQL4
uniprot id: F7FVC5
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100025649
gene id: 13616:LOC100025649
uniprot id: F6YZZ1
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

13616:IL17A
gene id: 13616:IL17A
uniprot id: F6YYN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

13616:DOK3
gene id: 13616:DOK3
uniprot id: F6U708
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

13616:NINJ2
gene id: 13616:NINJ2
uniprot id: A0A5F8G2D1
uniprot id: A0A5F8G3Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

13616:LOC100013458
gene id: 13616:LOC100013458
uniprot id: F7GHY7
names: Similarity
messages: Belongs to the IUNH family.

13616:SLC30A1
gene id: 13616:SLC30A1
uniprot id: A0A5F8GW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

13616:LOC100618597
gene id: 13616:LOC100618597
uniprot id: F7D893
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPFIBP1
gene id: 13616:PPFIBP1
uniprot id: A0A5F8GGX5
uniprot id: A0A5F8GKV8
uniprot id: A0A5F8H946
uniprot id: F7AUH6
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

13616:VN2R618
gene id: 13616:VN2R618
uniprot id: A0A5F8HJR3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ACTR6
gene id: 13616:ACTR6
uniprot id: A0A5F8G3U6
uniprot id: A0A5F8GWN0
uniprot id: F7F5S1
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

13616:LOC100013044
gene id: 13616:LOC100013044
uniprot id: F6SDJ3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

13616:TMCO3
gene id: 13616:TMCO3
uniprot id: F6ZKN9
names: Subcellular Location Annotation
messages: Membrane

13616:GABRB3
gene id: 13616:GABRB3
uniprot id: A0A5F8GFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:LOC100030396
gene id: 13616:LOC100030396
uniprot id: F7AP39
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

13616:LOC100015605
gene id: 13616:LOC100015605
uniprot id: F7AAB2
names: Similarity
messages: Belongs to the intermediate filament family.

13616:LOC103102954
gene id: 13616:LOC103102954
uniprot id: F6TAY5
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

13616:FAR1
gene id: 13616:FAR1
uniprot id: F6XVM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

13616:ACTL8
gene id: 13616:ACTL8
uniprot id: A0A5F8GQT3
names: Similarity
messages: Belongs to the actin family.

13616:GPRC5A
gene id: 13616:GPRC5A
uniprot id: F6PGM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RAP2B
gene id: 13616:RAP2B
uniprot id: F7DGX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

13616:AP4S1
gene id: 13616:AP4S1
uniprot id: F7B5W0
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

13616:VN2R551
gene id: 13616:VN2R551
uniprot id: A0A5F8GQV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:HMGCLL1
gene id: 13616:HMGCLL1
uniprot id: F7AD72
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

13616:ATP6AP2
gene id: 13616:ATP6AP2
uniprot id: F6UI11
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

13616:SCAMP2
gene id: 13616:SCAMP2
uniprot id: F7DA26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

13616:COG6
gene id: 13616:COG6
uniprot id: F6SS12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

13616:DUPD1
gene id: 13616:DUPD1
uniprot id: A0A5F8G707
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

13616:HOXA10
gene id: 13616:HOXA10
uniprot id: F6URM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:ACTL7A
gene id: 13616:ACTL7A
uniprot id: F6XB70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

13616:CCM2
gene id: 13616:CCM2
uniprot id: A0A5F8G7F0
names: Similarity
messages: Belongs to the CCM2 family.

13616:AGMAT
gene id: 13616:AGMAT
uniprot id: F7GBU4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

13616:PIGO
gene id: 13616:PIGO
uniprot id: F7AFE5
uniprot id: F7BJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100025737
gene id: 13616:LOC100025737
uniprot id: F6U4R6
names: Similarity
messages: Belongs to the yippee family.

13616:MMD
gene id: 13616:MMD
uniprot id: F7BZ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:MYB
gene id: 13616:MYB
uniprot id: A0A5F8GMD6
uniprot id: F7FEQ4
names: Subcellular Location Annotation
messages: Nucleus

13616:CNOT7
gene id: 13616:CNOT7
uniprot id: F7AXX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

13616:KLHL15
gene id: 13616:KLHL15
uniprot id: F7F5Y0
names: Subcellular Location Annotation
messages: Nucleus

13616:TLR3
gene id: 13616:TLR3
uniprot id: F6TNZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

13616:HEXA
gene id: 13616:HEXA
uniprot id: F6WJB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

13616:PDE9A
gene id: 13616:PDE9A
uniprot id: A0A5F8H0Q8
uniprot id: F7FKQ2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:LUC7L3
gene id: 13616:LUC7L3
uniprot id: A0A5F8GH27
names: Similarity
messages: Belongs to the Luc7 family.

13616:GDAP1
gene id: 13616:GDAP1
uniprot id: F6RGH2
names: Similarity
messages: Belongs to the GST superfamily.

13616:GUSB
gene id: 13616:GUSB
uniprot id: F7EJZ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

13616:ABCD3
gene id: 13616:ABCD3
uniprot id: A0A5F8HC77
uniprot id: A0A5F8HKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

13616:MAPK9
gene id: 13616:MAPK9
uniprot id: A0A5F8GYR6
uniprot id: F6WV79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

13616:LFNG
gene id: 13616:LFNG
uniprot id: F6YBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LPAR5
gene id: 13616:LPAR5
uniprot id: F7FFQ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:COPS3
gene id: 13616:COPS3
uniprot id: A0A5F8G7V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN3 family.
messages: Cytoplasm
messages: Nucleus

13616:WNT2
gene id: 13616:WNT2
uniprot id: Q2QL96
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

13616:PPA2
gene id: 13616:PPA2
uniprot id: F7EMS4
names: Similarity
messages: Belongs to the PPase family.

13616:STRN3
gene id: 13616:STRN3
uniprot id: F7BS62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

13616:ATP6V1C2
gene id: 13616:ATP6V1C2
uniprot id: A0A5F8GRV1
uniprot id: F7DMB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

13616:ORC2
gene id: 13616:ORC2
uniprot id: F7FHI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

13616:MMP2
gene id: 13616:MMP2
uniprot id: A0A5F8H9W3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M10A family.
messages: Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.
messages: extracellular matrix

13616:ONECUT1
gene id: 13616:ONECUT1
uniprot id: F6Z5A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

13616:TUBB6
gene id: 13616:TUBB6
uniprot id: F7CB79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:FAHD2A
gene id: 13616:FAHD2A
uniprot id: F7CKR3
names: Similarity
messages: Belongs to the FAH family.

13616:SLC25A33
gene id: 13616:SLC25A33
uniprot id: F6PNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:ALB
gene id: 13616:ALB
uniprot id: F7BJP5
names: Subcellular Location Annotation
messages: Secreted

13616:AKAP2
gene id: 13616:AKAP2
uniprot id: A0A5F8G4E3
uniprot id: A0A5F8HEI0
uniprot id: A0A5F8HJB2
uniprot id: F6V5J9
uniprot id: F6W529
names: Similarity
messages: Belongs to the paralemmin family.

13616:LOC100011319
gene id: 13616:LOC100011319
uniprot id: F6UXG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLAIN1
gene id: 13616:SLAIN1
uniprot id: A0A5F8G2F5
uniprot id: F7FHX9
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

13616:EXOSC3
gene id: 13616:EXOSC3
uniprot id: F6Q542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

13616:CDC37L1
gene id: 13616:CDC37L1
uniprot id: F6TL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

13616:GOLGA5
gene id: 13616:GOLGA5
uniprot id: F7GEH2
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

13616:DUT
gene id: 13616:DUT
uniprot id: F7CYM7
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

13616:GLRA1
gene id: 13616:GLRA1
uniprot id: F7G2F3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

13616:NCF2
gene id: 13616:NCF2
uniprot id: F6XAM8
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

13616:ANO3
gene id: 13616:ANO3
uniprot id: A0A5F8GUT3
uniprot id: F7CQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

13616:PYCR1
gene id: 13616:PYCR1
uniprot id: A0A5F8G2X3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

13616:RPS27
gene id: 13616:RPS27
uniprot id: F6SM23
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

13616:MTMR4
gene id: 13616:MTMR4
uniprot id: A0A5F8H7D5
uniprot id: A0A5F8HDQ1
uniprot id: F7D3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

13616:GUCA2B
gene id: 13616:GUCA2B
uniprot id: F6WWK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

13616:AKAP12
gene id: 13616:AKAP12
uniprot id: A0A5F8GQS1
uniprot id: A0A5F8HA15
uniprot id: A0A5F8HDM8
names: Subcellular Location Annotation
messages: Membrane

13616:ATP6V1G1
gene id: 13616:ATP6V1G1
uniprot id: F6QN45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:LOC100029871
gene id: 13616:LOC100029871
uniprot id: F7BKP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:XRCC3
gene id: 13616:XRCC3
uniprot id: F7D6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

13616:GH1
gene id: 13616:GH1
uniprot id: Q9GL60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).
messages: Secreted

13616:DYRK3
gene id: 13616:DYRK3
uniprot id: F6UZJ2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

13616:HAUS1
gene id: 13616:HAUS1
uniprot id: F6TZI7
uniprot id: K7E4I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

13616:HYAL3
gene id: 13616:HYAL3
uniprot id: F7CYI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Membrane
messages: acrosome

13616:LRRC8B
gene id: 13616:LRRC8B
uniprot id: F7G4V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

13616:NUDCD1
gene id: 13616:NUDCD1
uniprot id: F7BGF0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:C6H16orf71
gene id: 13616:C6H16orf71
uniprot id: K7E4S6
names: Function
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

13616:CCT8
gene id: 13616:CCT8
uniprot id: A0A5F8G524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

13616:RPL21
gene id: 13616:RPL21
uniprot id: F7GL67
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

13616:FAM83G
gene id: 13616:FAM83G
uniprot id: F7F4V4
names: Similarity
messages: Belongs to the FAM83 family.

13616:VPS11
gene id: 13616:VPS11
uniprot id: F6ZJC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

13616:TRAPPC13
gene id: 13616:TRAPPC13
uniprot id: A0A5F8G3C5
uniprot id: A0A5F8HBD7
uniprot id: F6UA19
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

13616:AR
gene id: 13616:AR
uniprot id: F6PME3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

13616:GNAQ
gene id: 13616:GNAQ
uniprot id: F7G1K7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

13616:LOC100018537
gene id: 13616:LOC100018537
uniprot id: F7DXV9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

13616:IRX5
gene id: 13616:IRX5
uniprot id: F7EWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:ALDH1B1
gene id: 13616:ALDH1B1
uniprot id: F7C0D1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

13616:SLC25A36
gene id: 13616:SLC25A36
uniprot id: F7B318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100026625
gene id: 13616:LOC100026625
uniprot id: F6TKJ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

13616:CSGALNACT2
gene id: 13616:CSGALNACT2
uniprot id: F7G7C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

13616:LOC100031974
gene id: 13616:LOC100031974
uniprot id: A0A5F8H3B9
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100028995
gene id: 13616:LOC100028995
uniprot id: F7BQ48
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VASN
gene id: 13616:VASN
uniprot id: A0A5F8GZI3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100012591
gene id: 13616:LOC100012591
uniprot id: F6QSG0
names: Subcellular Location Annotation
messages: Membrane

13616:SYNGR1
gene id: 13616:SYNGR1
uniprot id: A0A5F8GSF9
uniprot id: A0A5F8GZX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

13616:CDX1
gene id: 13616:CDX1
uniprot id: F6XTN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

13616:USP14
gene id: 13616:USP14
uniprot id: F7G2Y7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

13616:MAF1
gene id: 13616:MAF1
uniprot id: F7EAC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

13616:LOC103103296
gene id: 13616:LOC103103296
uniprot id: A0A5F8GVD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

13616:SLC23A2
gene id: 13616:SLC23A2
uniprot id: F6U0C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

13616:TMEM94
gene id: 13616:TMEM94
uniprot id: F6YYK0
names: Subcellular Location Annotation
messages: Membrane

13616:CGA
gene id: 13616:CGA
uniprot id: Q6YNX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

13616:MDM4
gene id: 13616:MDM4
uniprot id: A0A5F8G9Z5
uniprot id: F7BAJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

13616:ELK4
gene id: 13616:ELK4
uniprot id: F6T5N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:ARHGEF6
gene id: 13616:ARHGEF6
uniprot id: A0A5F8H4J3
uniprot id: A0A5F8HIS3
uniprot id: F6TST1
names: Subcellular Location Annotation
messages: lamellipodium

13616:LOC100015365
gene id: 13616:LOC100015365
uniprot id: A0A5F8G632
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

13616:NME3
gene id: 13616:NME3
uniprot id: F7DRU3
names: Similarity
messages: Belongs to the NDK family.

13616:LOC100022188
gene id: 13616:LOC100022188
uniprot id: A0A5F8GGM0
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

13616:LOC100020266
gene id: 13616:LOC100020266
uniprot id: A0A5F8G8J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VCP
gene id: 13616:VCP
uniprot id: F6ZIF4
names: Similarity
messages: Belongs to the AAA ATPase family.

13616:C2H17orf105
gene id: 13616:C2H17orf105
uniprot id: A0A5F8HE01
names: Similarity
messages: Belongs to the CFAP97 family.

13616:CCDC153
gene id: 13616:CCDC153
uniprot id: F7ECW8
names: Similarity
messages: Belongs to the UPF0610 family.

13616:BHMT
gene id: 13616:BHMT
uniprot id: F6X4V0
names: Cofactor
messages: Binds 1 zinc ion per subunit.

13616:HOOK1
gene id: 13616:HOOK1
uniprot id: A0A5F8HFR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

13616:MTHFR
gene id: 13616:MTHFR
uniprot id: A0A5F8GXA9
uniprot id: F7AQ98
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

13616:SLC25A41
gene id: 13616:SLC25A41
uniprot id: F6VJ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:KCNAB1
gene id: 13616:KCNAB1
uniprot id: A0A5F8HBH3
uniprot id: F7AGZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

13616:COG1
gene id: 13616:COG1
uniprot id: F7F869
names: Similarity
messages: Belongs to the COG1 family.

13616:GLUL
gene id: 13616:GLUL
uniprot id: F6PH60
names: Similarity
messages: Belongs to the glutamine synthetase family.

13616:GLDC
gene id: 13616:GLDC
uniprot id: F6V2Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

13616:GGPS1
gene id: 13616:GGPS1
uniprot id: A0A5F8H0Y3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

13616:MAP3K6
gene id: 13616:MAP3K6
uniprot id: F6ZG40
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

13616:MTHFD1L
gene id: 13616:MTHFD1L
uniprot id: F7GGC9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

13616:EVC2
gene id: 13616:EVC2
uniprot id: F6XGD8
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

13616:MED18
gene id: 13616:MED18
uniprot id: A0A5F8GYN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

13616:MAPK7
gene id: 13616:MAPK7
uniprot id: F6YQF9
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

13616:PPP4R3B
gene id: 13616:PPP4R3B
uniprot id: F6W0L9
names: Similarity
messages: Belongs to the SMEK family.

13616:ATXN1
gene id: 13616:ATXN1
uniprot id: F7BE53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

13616:OPN1LW
gene id: 13616:OPN1LW
uniprot id: B9MSR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

13616:LOC100016646
gene id: 13616:LOC100016646
uniprot id: F6ZJ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

13616:LOC100028162
gene id: 13616:LOC100028162
uniprot id: F6TW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:AP1G1
gene id: 13616:AP1G1
uniprot id: A0A5F8G3R4
uniprot id: F7EH71
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

13616:OLFM3
gene id: 13616:OLFM3
uniprot id: A0A5F8G5Z1
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

13616:SCAP
gene id: 13616:SCAP
uniprot id: F6X2Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

13616:KEG11 p04
gene id: 13616:KEG11_p04
uniprot id: Q65CI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion membrane

13616:LOC100020348
gene id: 13616:LOC100020348
uniprot id: F6YGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:B3GAT3
gene id: 13616:B3GAT3
uniprot id: F6ZIQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:SLC17A6
gene id: 13616:SLC17A6
uniprot id: F6YX10
names: Subcellular Location Annotation
messages: Membrane

13616:FLNA
gene id: 13616:FLNA
uniprot id: A0A5F8GAD9
names: Similarity
messages: Belongs to the filamin family.

13616:ARRB1
gene id: 13616:ARRB1
uniprot id: A0A5F8G9J9
names: Similarity
messages: Belongs to the arrestin family.

13616:TPST2
gene id: 13616:TPST2
uniprot id: F7G7U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

13616:LOC100027575
gene id: 13616:LOC100027575
uniprot id: A0A5F8GC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FGF17
gene id: 13616:FGF17
uniprot id: F6SHQ2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:UCN2
gene id: 13616:UCN2
uniprot id: A0A5F8GIE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

13616:LOC100012618
gene id: 13616:LOC100012618
uniprot id: A0A5F8HI30
uniprot id: F7FZ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:SSTR1
gene id: 13616:SSTR1
uniprot id: F7AMI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ART1
gene id: 13616:ART1
uniprot id: F6ZXV5
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

13616:EWSR1
gene id: 13616:EWSR1
uniprot id: F6PFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

13616:FMR1
gene id: 13616:FMR1
uniprot id: A0A5F8GMX8
uniprot id: A0A5F8GRP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

13616:LOC103096822
gene id: 13616:LOC103096822
uniprot id: F6QYH1
names: Similarity
messages: Belongs to the thioredoxin family.

13616:TOP2B
gene id: 13616:TOP2B
uniprot id: F7D0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

13616:ARL6
gene id: 13616:ARL6
uniprot id: F6QF28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

13616:CECR6
gene id: 13616:CECR6
uniprot id: F6XBQ2
names: Similarity
messages: Belongs to the TMEM121 family.

13616:LOC100010256
gene id: 13616:LOC100010256
uniprot id: F7CA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMSB10
gene id: 13616:TMSB10
uniprot id: A0A5F8GWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:MMACHC
gene id: 13616:MMACHC
uniprot id: A0A5F8GF05
names: Similarity
messages: Belongs to the MMACHC family.

13616:LOC100618884
gene id: 13616:LOC100618884
uniprot id: F6XZ86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:MRPS5
gene id: 13616:MRPS5
uniprot id: F6WC63
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

13616:LOC100029406
gene id: 13616:LOC100029406
uniprot id: F7EYD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FAM3B
gene id: 13616:FAM3B
uniprot id: A0A5F8GNJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

13616:DNAJC24
gene id: 13616:DNAJC24
uniprot id: F7BJ34
names: Similarity
messages: Belongs to the DPH4 family.

13616:PRL
gene id: 13616:PRL
uniprot id: O62819
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

13616:SLC15A2
gene id: 13616:SLC15A2
uniprot id: F6Q744
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

13616:RCAN1
gene id: 13616:RCAN1
uniprot id: A0A5F8H8K5
uniprot id: F6VJK2
names: Similarity
messages: Belongs to the RCAN family.

13616:YIPF4
gene id: 13616:YIPF4
uniprot id: F6WWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

13616:ATG9B
gene id: 13616:ATG9B
uniprot id: A0A5F8GNS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

13616:CNOT11
gene id: 13616:CNOT11
uniprot id: F6X050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100023173
gene id: 13616:LOC100023173
uniprot id: F6YL42
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:NLGN1
gene id: 13616:NLGN1
uniprot id: D2X2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

13616:LOC100021121
gene id: 13616:LOC100021121
uniprot id: F7ANK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CAST
gene id: 13616:CAST
uniprot id: A0A5F8H065
uniprot id: F7GIJ5
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

13616:LOC100029204
gene id: 13616:LOC100029204
uniprot id: F6XCC1
names: Similarity
messages: Belongs to the BASP1 family.

13616:ATE1
gene id: 13616:ATE1
uniprot id: A0A5F8G9F9
uniprot id: A0A5F8GQP8
uniprot id: A0A5F8HAZ4
uniprot id: F7AKZ0
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

13616:LOC100033269
gene id: 13616:LOC100033269
uniprot id: A0A5F8H860
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:LOC100025565
gene id: 13616:LOC100025565
uniprot id: F7FI80
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:DYDC1
gene id: 13616:DYDC1
uniprot id: F7EMW4
names: Similarity
messages: Belongs to the dpy-30 family.

13616:SCAMP1
gene id: 13616:SCAMP1
uniprot id: A0A5F8G4G0
uniprot id: A0A5F8GKC9
uniprot id: A0A5F8HFM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

13616:PDGFRA
gene id: 13616:PDGFRA
uniprot id: F7E5I9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

13616:PCMTD2
gene id: 13616:PCMTD2
uniprot id: F6VKL8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

13616:SLC1A6
gene id: 13616:SLC1A6
uniprot id: A0A5F8G9Q7
uniprot id: F7FKW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

13616:CRH
gene id: 13616:CRH
uniprot id: F6UTQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

13616:NFIA
gene id: 13616:NFIA
uniprot id: A0A5F8GRT1
uniprot id: F7BW75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

13616:KCNK1
gene id: 13616:KCNK1
uniprot id: F7DH29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

13616:LOC100024418
gene id: 13616:LOC100024418
uniprot id: F6VJ03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

13616:LOC100012199
gene id: 13616:LOC100012199
uniprot id: A0A5F8GBC3
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

13616:RBKS
gene id: 13616:RBKS
uniprot id: F6ZV41
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

13616:RHBDF1
gene id: 13616:RHBDF1
uniprot id: F6YNC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

13616:LOC100030404
gene id: 13616:LOC100030404
uniprot id: F6ZP21
names: Subcellular Location Annotation
messages: Membrane

13616:PRIM2
gene id: 13616:PRIM2
uniprot id: F7FCC2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

13616:LOC103105351
gene id: 13616:LOC103105351
uniprot id: F6VY82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100020750
gene id: 13616:LOC100020750
uniprot id: F7EXX3
names: Similarity
messages: Belongs to the fructosamine kinase family.

13616:HOXD1
gene id: 13616:HOXD1
uniprot id: F7A8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

13616:SYNE4
gene id: 13616:SYNE4
uniprot id: A0A5F8G308
names: Similarity
messages: Belongs to the nesprin family.

13616:ZCCHC8
gene id: 13616:ZCCHC8
uniprot id: F6YGG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

13616:ATP6V0D1
gene id: 13616:ATP6V0D1
uniprot id: F6XCI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:YDJC
gene id: 13616:YDJC
uniprot id: F6YJB8
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

13616:A4GNT
gene id: 13616:A4GNT
uniprot id: F7G2J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

13616:MOK
gene id: 13616:MOK
uniprot id: F7GJG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:MODO-UE
gene id: 13616:MODO-UE
uniprot id: C6ZIV3
names: Similarity
messages: Belongs to the MHC class I family.

13616:NIF3L1
gene id: 13616:NIF3L1
uniprot id: F7FUK4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

13616:QPCTL
gene id: 13616:QPCTL
uniprot id: F7DZS6
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

13616:TPX2
gene id: 13616:TPX2
uniprot id: F6WA27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

13616:MFNG
gene id: 13616:MFNG
uniprot id: A0A5F8H3A0
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100020485
gene id: 13616:LOC100020485
uniprot id: F7E0N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100021749
gene id: 13616:LOC100021749
uniprot id: F6PZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GOT2
gene id: 13616:GOT2
uniprot id: F6XJK0
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

13616:NDUFAF7
gene id: 13616:NDUFAF7
uniprot id: F6ZX82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

13616:HTR2C
gene id: 13616:HTR2C
uniprot id: A0A5F8G9X4
uniprot id: F7BES5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

13616:ALDH1A2
gene id: 13616:ALDH1A2
uniprot id: F6PGG8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

13616:CHAC1
gene id: 13616:CHAC1
uniprot id: F6TFR6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

13616:TMEM70
gene id: 13616:TMEM70
uniprot id: A0A5F8H858
names: Similarity
messages: Belongs to the TMEM70 family.

13616:ASF1B
gene id: 13616:ASF1B
uniprot id: F7G4J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

13616:KCNG3
gene id: 13616:KCNG3
uniprot id: F6RUG0
names: Subcellular Location Annotation
messages: Membrane

13616:IDH2
gene id: 13616:IDH2
uniprot id: F6VD67
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

13616:MGAT1
gene id: 13616:MGAT1
uniprot id: F7EGJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

13616:VN2R594
gene id: 13616:VN2R594
uniprot id: F7BS98
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:FAM65A
gene id: 13616:FAM65A
uniprot id: F6TL03
names: Similarity
messages: Belongs to the RIPOR family.

13616:RAD52
gene id: 13616:RAD52
uniprot id: F6Q9I8
names: Similarity
messages: Belongs to the RAD52 family.

13616:METTL8
gene id: 13616:METTL8
uniprot id: A0A5F8G613
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

13616:RDH11
gene id: 13616:RDH11
uniprot id: F6US93
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:AARS
gene id: 13616:AARS
uniprot id: F7ERQ8
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

13616:LOC100031601
gene id: 13616:LOC100031601
uniprot id: F6VB69
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

13616:USP45
gene id: 13616:USP45
uniprot id: F7FFP8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:DXO
gene id: 13616:DXO
uniprot id: F7BXD2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

13616:GTF2H1
gene id: 13616:GTF2H1
uniprot id: F7BVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

13616:MED21
gene id: 13616:MED21
uniprot id: A0A5F8GU78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

13616:TPH1
gene id: 13616:TPH1
uniprot id: F7DGX6
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

13616:GRAMD1C
gene id: 13616:GRAMD1C
uniprot id: F7CCG4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:HDDC2
gene id: 13616:HDDC2
uniprot id: F7FUJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

13616:LOC100016938
gene id: 13616:LOC100016938
uniprot id: A0A5F8GV92
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:GRN
gene id: 13616:GRN
uniprot id: F6QWT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

13616:BCL2L10
gene id: 13616:BCL2L10
uniprot id: F6VJQ0
names: Similarity
messages: Belongs to the Bcl-2 family.

13616:LOC100026774
gene id: 13616:LOC100026774
uniprot id: F6SKF7
names: Similarity
messages: Belongs to the NSG family.

13616:SLC5A11
gene id: 13616:SLC5A11
uniprot id: F7AU44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:PHGDH
gene id: 13616:PHGDH
uniprot id: A0A5F8GBC1
uniprot id: F7FVB4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

13616:MSTO1
gene id: 13616:MSTO1
uniprot id: F6QEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

13616:PRRX2
gene id: 13616:PRRX2
uniprot id: F7BTR9
names: Subcellular Location Annotation
messages: Nucleus

13616:SNAPC3
gene id: 13616:SNAPC3
uniprot id: F7D0E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

13616:VN2R570
gene id: 13616:VN2R570
uniprot id: A0A5F8GA41
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:GNPTAB
gene id: 13616:GNPTAB
uniprot id: F6XPQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

13616:LOC103104413
gene id: 13616:LOC103104413
uniprot id: K7E690
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:NIPAL2
gene id: 13616:NIPAL2
uniprot id: A0A5F8GJ27
uniprot id: F7CDM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:ELP6
gene id: 13616:ELP6
uniprot id: A0A5F8GXR4
names: Similarity
messages: Belongs to the ELP6 family.

13616:LOC100031124
gene id: 13616:LOC100031124
uniprot id: A0A5F8HAU3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100020874
gene id: 13616:LOC100020874
uniprot id: F7FSX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

13616:ELP5
gene id: 13616:ELP5
uniprot id: F6WSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

13616:LYRM2
gene id: 13616:LYRM2
uniprot id: F6Q754
names: Similarity
messages: Belongs to the complex I LYR family.

13616:MMAB
gene id: 13616:MMAB
uniprot id: F6V9Y7
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

13616:KCNJ5
gene id: 13616:KCNJ5
uniprot id: F6WK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

13616:FAM227A
gene id: 13616:FAM227A
uniprot id: F6RRH5
names: Similarity
messages: Belongs to the FAM227 family.

13616:LOC100018839
gene id: 13616:LOC100018839
uniprot id: A0A5F8GFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:SLC10A3
gene id: 13616:SLC10A3
uniprot id: F6QFJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

13616:C3H5orf28
gene id: 13616:C3H5orf28
uniprot id: F6QB74
names: Subcellular Location Annotation
messages: Membrane

13616:NEMF
gene id: 13616:NEMF
uniprot id: F6XWM2
names: Similarity
messages: Belongs to the NEMF family.

13616:OCLN
gene id: 13616:OCLN
uniprot id: F6SYJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

13616:NAXE
gene id: 13616:NAXE
uniprot id: F7FIH8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity).
messages: Homodimer (By similarity). Interacts with APOA1 and APOA2 (By similarity).
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

13616:LOC100010772
gene id: 13616:LOC100010772
uniprot id: F7G5N4
names: Similarity
messages: Belongs to the SELO family.

13616:FGG
gene id: 13616:FGG
uniprot id: F7CIN4
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

13616:ETV2
gene id: 13616:ETV2
uniprot id: A0A5F8G8C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:NPBWR2
gene id: 13616:NPBWR2
uniprot id: F6XHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IL1B
gene id: 13616:IL1B
uniprot id: F6SXC0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

13616:ZP1
gene id: 13616:ZP1
uniprot id: F6WXF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:OSBP
gene id: 13616:OSBP
uniprot id: F7G832
names: Similarity
messages: Belongs to the OSBP family.

13616:LOC100018892
gene id: 13616:LOC100018892
uniprot id: K7E3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100618392
gene id: 13616:LOC100618392
uniprot id: F7EQA7
names: Similarity
messages: Belongs to the intermediate filament family.

13616:GCLC
gene id: 13616:GCLC
uniprot id: A0A5F8HLU9
uniprot id: F6ZMX9
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

13616:SNX13
gene id: 13616:SNX13
uniprot id: F7APQ1
names: Similarity
messages: Belongs to the sorting nexin family.

13616:LOC100032661
gene id: 13616:LOC100032661
uniprot id: F7FUJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

13616:SEPT10
gene id: 13616:SEPT10
uniprot id: A0A5F8HHZ6
uniprot id: F6PI38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

13616:GATM
gene id: 13616:GATM
uniprot id: F6Z4H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

13616:LOC103096593
gene id: 13616:LOC103096593
uniprot id: A0A5F8G3R0
uniprot id: A0A5F8H7F0
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:G6PC
gene id: 13616:G6PC
uniprot id: A0A5F8G347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

13616:PEX12
gene id: 13616:PEX12
uniprot id: F7EUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

13616:MAN1A2
gene id: 13616:MAN1A2
uniprot id: F7DMZ8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

13616:AUH
gene id: 13616:AUH
uniprot id: F6QU09
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:NCDN
gene id: 13616:NCDN
uniprot id: F7F334
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

13616:FPGS
gene id: 13616:FPGS
uniprot id: A0A5F8H657
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

13616:ALOX12B
gene id: 13616:ALOX12B
uniprot id: F7FZA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GAS6
gene id: 13616:GAS6
uniprot id: F7BMD1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:KIFC1
gene id: 13616:KIFC1
uniprot id: F6XKS9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:LOC100021084
gene id: 13616:LOC100021084
uniprot id: F6RPE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NPPC
gene id: 13616:NPPC
uniprot id: F7B965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

13616:ETV7
gene id: 13616:ETV7
uniprot id: F7C2W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:monDomV1R1255
gene id: 13616:monDomV1R1255
uniprot id: A0A5F8GN91
uniprot id: F6V7I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CCNB1
gene id: 13616:CCNB1
uniprot id: F6TCH9
names: Similarity
messages: Belongs to the cyclin family.

13616:COCH
gene id: 13616:COCH
uniprot id: F7BSI0
names: Function
messages: Plays a role in the control of cell shape and motility in the trabecular meshwork.

13616:monDomV1R1208
gene id: 13616:monDomV1R1208
uniprot id: A0A5F8G944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CHRNB1
gene id: 13616:CHRNB1
uniprot id: F6RFH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:FAM129A
gene id: 13616:FAM129A
uniprot id: F7ADC1
names: Similarity
messages: Belongs to the Niban family.

13616:CFAP97
gene id: 13616:CFAP97
uniprot id: A0A5F8GEJ1
uniprot id: A0A5F8HC82
names: Similarity
messages: Belongs to the CFAP97 family.

13616:LEP
gene id: 13616:LEP
uniprot id: A0A5F8GBV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

13616:SCNM1
gene id: 13616:SCNM1
uniprot id: A0A5F8G956
uniprot id: A0A5F8HJX6
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

13616:GDF9
gene id: 13616:GDF9
uniprot id: A0A5F8H619
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

13616:LOC100009995
gene id: 13616:LOC100009995
uniprot id: F6QZ90
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:GADD45A
gene id: 13616:GADD45A
uniprot id: F6SSE6
names: Similarity
messages: Belongs to the GADD45 family.

13616:ELMO2
gene id: 13616:ELMO2
uniprot id: A0A5F8G6Y5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

13616:STIM1
gene id: 13616:STIM1
uniprot id: A0A5F8GHF9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:TNR
gene id: 13616:TNR
uniprot id: F7BXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

13616:PNPT1
gene id: 13616:PNPT1
uniprot id: F6RID9
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

13616:LOC100017048
gene id: 13616:LOC100017048
uniprot id: F7FJK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

13616:GAS8
gene id: 13616:GAS8
uniprot id: A0A5F8H576
uniprot id: A0A5F8HET4
uniprot id: F7EG11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

13616:DARS2
gene id: 13616:DARS2
uniprot id: F6Y9Y7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

13616:KCNV1
gene id: 13616:KCNV1
uniprot id: A0A5F8G5X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

13616:LOC100030489
gene id: 13616:LOC100030489
uniprot id: F7AGA4
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6c family.

13616:TRPC4
gene id: 13616:TRPC4
uniprot id: F6TA59
names: Subcellular Location Annotation
messages: Membrane

13616:PPP2R5D
gene id: 13616:PPP2R5D
uniprot id: F7C5Z9
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

13616:LOC100026112
gene id: 13616:LOC100026112
uniprot id: F7DNL5
names: Similarity
messages: Belongs to the MHC class II family.

13616:DNM1L
gene id: 13616:DNM1L
uniprot id: A0A5F8HCP4
uniprot id: F6WIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

13616:SRD5A3
gene id: 13616:SRD5A3
uniprot id: A0A5F8H8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

13616:GTF2A2
gene id: 13616:GTF2A2
uniprot id: F6TJT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

13616:KCNJ3
gene id: 13616:KCNJ3
uniprot id: F6UBI7
uniprot id: F6YV60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

13616:RSG1
gene id: 13616:RSG1
uniprot id: F6THU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

13616:ZDHHC24
gene id: 13616:ZDHHC24
uniprot id: F7E5D5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:ARHGEF7
gene id: 13616:ARHGEF7
uniprot id: A0A5F8GKA8
uniprot id: A0A5F8GY41
uniprot id: A0A5F8HA32
uniprot id: F6VRF8
names: Subcellular Location Annotation
messages: lamellipodium

13616:SESN2
gene id: 13616:SESN2
uniprot id: F7ARK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

13616:FAM72A
gene id: 13616:FAM72A
uniprot id: F6RIT0
names: Similarity
messages: Belongs to the FAM72 family.

13616:CPZ
gene id: 13616:CPZ
uniprot id: A0A5F8HL88
uniprot id: F6TZK5
names: Caution
names: Similarity
messages: Belongs to the peptidase M14 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TP53RK
gene id: 13616:TP53RK
uniprot id: K7DZC6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

13616:LTC4S
gene id: 13616:LTC4S
uniprot id: F7EVP5
names: Subcellular Location Annotation
messages: Membrane

13616:AOX4
gene id: 13616:AOX4
uniprot id: M1ZMS0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

13616:YIPF3
gene id: 13616:YIPF3
uniprot id: F7G044
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

13616:GPLD1
gene id: 13616:GPLD1
uniprot id: F6UZA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

13616:MFSD9
gene id: 13616:MFSD9
uniprot id: A0A5F8GGS5
names: Subcellular Location Annotation
messages: Membrane

13616:NRDE2
gene id: 13616:NRDE2
uniprot id: F7CXT9
names: Similarity
messages: Belongs to the NRDE2 family.

13616:SLC8A2
gene id: 13616:SLC8A2
uniprot id: F6VFC4
names: Subcellular Location Annotation
messages: Membrane

13616:IQCG
gene id: 13616:IQCG
uniprot id: F6QUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

13616:CPB1
gene id: 13616:CPB1
uniprot id: F6TIT0
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:ZDHHC3
gene id: 13616:ZDHHC3
uniprot id: A0A5F8GFF1
uniprot id: F6RLV5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:GPD2
gene id: 13616:GPD2
uniprot id: F6X5V3
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

13616:LOC100018857
gene id: 13616:LOC100018857
uniprot id: A0A5F8HKT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:BCAP31
gene id: 13616:BCAP31
uniprot id: A0A5F8G548
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

13616:LOC100023848
gene id: 13616:LOC100023848
uniprot id: F6Q1P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TBC1D23
gene id: 13616:TBC1D23
uniprot id: A0A5F8H472
uniprot id: F7DG20
names: Subcellular Location Annotation
messages: trans-Golgi network

13616:KCNMB1
gene id: 13616:KCNMB1
uniprot id: A0A5F8GN68
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

13616:VN2R516
gene id: 13616:VN2R516
uniprot id: A0A5F8GCZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PAPOLG
gene id: 13616:PAPOLG
uniprot id: A0A5F8G3M1
uniprot id: F6YET0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

13616:MAX
gene id: 13616:MAX
uniprot id: A0A5F8G728
uniprot id: A0A5F8GK25
uniprot id: A0A5F8HCQ6
names: Similarity
messages: Belongs to the MAX family.

13616:RNASEH1
gene id: 13616:RNASEH1
uniprot id: F7FKT3
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

13616:CBLB
gene id: 13616:CBLB
uniprot id: A0A5F8G7Q1
uniprot id: F6T5M5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

13616:VPS26B
gene id: 13616:VPS26B
uniprot id: F7FVE6
names: Similarity
messages: Belongs to the VPS26 family.

13616:TMEM159
gene id: 13616:TMEM159
uniprot id: F6WTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

13616:LOC100031295
gene id: 13616:LOC100031295
uniprot id: F6UH76
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:S100A1
gene id: 13616:S100A1
uniprot id: F6VYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

13616:GRB14
gene id: 13616:GRB14
uniprot id: A0A5F8H9F8
uniprot id: F6XXY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

13616:DHTKD1
gene id: 13616:DHTKD1
uniprot id: F7FVJ6
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

13616:OTUD7B
gene id: 13616:OTUD7B
uniprot id: F7AE38
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:SLC29A4
gene id: 13616:SLC29A4
uniprot id: F7ESE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

13616:KCNV2
gene id: 13616:KCNV2
uniprot id: F7BMH8
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100021392
gene id: 13616:LOC100021392
uniprot id: F6ZZ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PROC
gene id: 13616:PROC
uniprot id: F7AEE9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:SPOCK3
gene id: 13616:SPOCK3
uniprot id: A0A5F8HID6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NSUN5
gene id: 13616:NSUN5
uniprot id: F6WS57
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

13616:GIPR
gene id: 13616:GIPR
uniprot id: F6WUD5
names: Subcellular Location Annotation
messages: Membrane

13616:RND3
gene id: 13616:RND3
uniprot id: F6RYV4
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

13616:SLC2A12
gene id: 13616:SLC2A12
uniprot id: F7F0U7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:LOC100011551
gene id: 13616:LOC100011551
uniprot id: K7DZE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

13616:AGO2
gene id: 13616:AGO2
uniprot id: F6VPM9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.
messages: Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA-and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36.
messages: Nucleus
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
messages: The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).

13616:OPALIN
gene id: 13616:OPALIN
uniprot id: F6T2B6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

13616:LOC100022164
gene id: 13616:LOC100022164
uniprot id: F7BDE2
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

13616:FAM129C
gene id: 13616:FAM129C
uniprot id: F6SVS0
names: Similarity
messages: Belongs to the Niban family.

13616:LOC100017849
gene id: 13616:LOC100017849
uniprot id: F7ARZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RNF20
gene id: 13616:RNF20
uniprot id: F7AUI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

13616:LOC100023762
gene id: 13616:LOC100023762
uniprot id: F6ZH50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ZBED4
gene id: 13616:ZBED4
uniprot id: F6VLV3
names: Subcellular Location Annotation
messages: Nucleus

13616:FAAH2
gene id: 13616:FAAH2
uniprot id: F7F0S7
names: Similarity
messages: Belongs to the amidase family.

13616:CLPTM1L
gene id: 13616:CLPTM1L
uniprot id: F7EAA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

13616:NACC1
gene id: 13616:NACC1
uniprot id: F6U150
names: Subcellular Location Annotation
messages: Nucleus

13616:CNOT6
gene id: 13616:CNOT6
uniprot id: F7F909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

13616:MCHR1
gene id: 13616:MCHR1
uniprot id: A0A5F8HBM5
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

13616:SLC9A3R1
gene id: 13616:SLC9A3R1
uniprot id: F6Q7D5
names: Function
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

13616:NTNG2
gene id: 13616:NTNG2
uniprot id: A0A5F8HKK9
uniprot id: F6Q0S1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:monDomV1R1211
gene id: 13616:monDomV1R1211
uniprot id: A0A5F8GSD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPP6C
gene id: 13616:PPP6C
uniprot id: A0A5F8HHF5
names: Similarity
messages: Belongs to the PPP phosphatase family.

13616:WRB
gene id: 13616:WRB
uniprot id: A0A5F8GGM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:NME1
gene id: 13616:NME1
uniprot id: A0A5F8GG11
uniprot id: A0A5F8GM45
uniprot id: F6PIN1
names: Similarity
messages: Belongs to the NDK family.

13616:PROK2
gene id: 13616:PROK2
uniprot id: A0A5F8HE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

13616:TIMM8B
gene id: 13616:TIMM8B
uniprot id: F6T6S9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

13616:TANGO6
gene id: 13616:TANGO6
uniprot id: A0A5F8GJE4
names: Similarity
messages: Belongs to the Tango6 family.

13616:AGBL2
gene id: 13616:AGBL2
uniprot id: A0A5F8GD42
uniprot id: F6VP01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

13616:EREG
gene id: 13616:EREG
uniprot id: F7A8Z0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GAD1
gene id: 13616:GAD1
uniprot id: F7DHD9
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

13616:SPTB
gene id: 13616:SPTB
uniprot id: F6Q881
names: Similarity
messages: Belongs to the spectrin family.

13616:IVD
gene id: 13616:IVD
uniprot id: F6VDN3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:OXTR
gene id: 13616:OXTR
uniprot id: F6U716
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

13616:LOC103092827
gene id: 13616:LOC103092827
uniprot id: A0A5F8HK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

13616:KAT2B
gene id: 13616:KAT2B
uniprot id: F7A3N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

13616:SLC39A6
gene id: 13616:SLC39A6
uniprot id: F6UAP6
names: Subcellular Location Annotation
messages: Membrane

13616:DDX11
gene id: 13616:DDX11
uniprot id: F6RFQ7
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.

13616:PIM2
gene id: 13616:PIM2
uniprot id: F6TUF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:ENAH
gene id: 13616:ENAH
uniprot id: A0A5F8GGR9
uniprot id: F7FCN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

13616:LOC100018877
gene id: 13616:LOC100018877
uniprot id: F6PX60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:LOC100013147
gene id: 13616:LOC100013147
uniprot id: F7C2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100023655
gene id: 13616:LOC100023655
uniprot id: A0A5F8GPP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

13616:PEX1
gene id: 13616:PEX1
uniprot id: F7G7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

13616:SH3KBP1
gene id: 13616:SH3KBP1
uniprot id: F7DH99
names: Subcellular Location Annotation
messages: focal adhesion

13616:DNPH1
gene id: 13616:DNPH1
uniprot id: F7FPA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer.
messages: Nucleus

13616:PGC
gene id: 13616:PGC
uniprot id: Q689Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes various peptides including beta-endorphin, insulin B chain, dynorphin A, and neurokinin A, with high specificity for the cleavage of the Phe-Xaa bonds.
messages: Secreted

13616:ACKR1
gene id: 13616:ACKR1
uniprot id: A0A5F8HGN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

13616:LOC100021064
gene id: 13616:LOC100021064
uniprot id: F7CGM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:PDSS1
gene id: 13616:PDSS1
uniprot id: F7DHD1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

13616:SNAP23
gene id: 13616:SNAP23
uniprot id: F7FGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

13616:MRPL13
gene id: 13616:MRPL13
uniprot id: A0A5F8GC35
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

13616:PNRC2
gene id: 13616:PNRC2
uniprot id: F7C7J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

13616:LOC100022478
gene id: 13616:LOC100022478
uniprot id: F7BRM4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

13616:SNAPIN
gene id: 13616:SNAPIN
uniprot id: A0A5F8G8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

13616:CSF3
gene id: 13616:CSF3
uniprot id: F7CRM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

13616:CXCL13
gene id: 13616:CXCL13
uniprot id: A0A5F8GSS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

13616:GCNT7
gene id: 13616:GCNT7
uniprot id: F7A4Z1
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100023527
gene id: 13616:LOC100023527
uniprot id: F7FMD0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:SLC25A46
gene id: 13616:SLC25A46
uniprot id: A0A5F8GUW1
uniprot id: F7F157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

13616:LOC100021368
gene id: 13616:LOC100021368
uniprot id: A0A5F8H5C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:VTI1A
gene id: 13616:VTI1A
uniprot id: F6TAL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

13616:GLP1R
gene id: 13616:GLP1R
uniprot id: F6ZL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

13616:TAS2R60
gene id: 13616:TAS2R60
uniprot id: Q2AB85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:CRKL
gene id: 13616:CRKL
uniprot id: F6Z4K4
names: Similarity
messages: Belongs to the CRK family.

13616:LOC103092765
gene id: 13616:LOC103092765
uniprot id: F7DWH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ZDHHC9
gene id: 13616:ZDHHC9
uniprot id: F7EDC7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:LOC100030075
gene id: 13616:LOC100030075
uniprot id: A0A5F8GV77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NPEPPS
gene id: 13616:NPEPPS
uniprot id: F6PLN8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:PIN4
gene id: 13616:PIN4
uniprot id: A0A5F8GMX7
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

13616:NUP85
gene id: 13616:NUP85
uniprot id: F6VWW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

13616:PLK4
gene id: 13616:PLK4
uniprot id: F6YGH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

13616:AVL9
gene id: 13616:AVL9
uniprot id: F7DF01
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

13616:LOC100019084
gene id: 13616:LOC100019084
uniprot id: F7FQM8
names: Subcellular Location Annotation
messages: Membrane

13616:TGS1
gene id: 13616:TGS1
uniprot id: F7ADF5
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

13616:FZD3
gene id: 13616:FZD3
uniprot id: F6PWM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PKNOX2
gene id: 13616:PKNOX2
uniprot id: A0A5F8H3S9
uniprot id: F7D6U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

13616:LOC103099758
gene id: 13616:LOC103099758
uniprot id: F7GEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SNX30
gene id: 13616:SNX30
uniprot id: A0A5F8GU33
names: Similarity
messages: Belongs to the sorting nexin family.

13616:PEX13
gene id: 13616:PEX13
uniprot id: F7DG26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

13616:DNTT
gene id: 13616:DNTT
uniprot id: O02789
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-X family.
messages: Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).
messages: Interacts with PRP19 and DNTTIP1. Interacts with TRERF1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA (By similarity).
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

13616:LOC100022472
gene id: 13616:LOC100022472
uniprot id: F7CU36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100029345
gene id: 13616:LOC100029345
uniprot id: A0A5F8H096
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

13616:STARD6
gene id: 13616:STARD6
uniprot id: F7EML9
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

13616:SERPINH1
gene id: 13616:SERPINH1
uniprot id: F6PGJ9
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

13616:GUF1
gene id: 13616:GUF1
uniprot id: F7A0N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

13616:BDKRB2
gene id: 13616:BDKRB2
uniprot id: A0A5F8H7W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

13616:LOC100022049
gene id: 13616:LOC100022049
uniprot id: F6W8M3
names: Similarity
messages: Belongs to the ficolin lectin family.

13616:monDomV1R1267
gene id: 13616:monDomV1R1267
uniprot id: F6V7E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPARA
gene id: 13616:PPARA
uniprot id: F7ADB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

13616:WDR48
gene id: 13616:WDR48
uniprot id: A0A5F8HFM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

13616:POP7
gene id: 13616:POP7
uniprot id: F6R4U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

13616:MSX2
gene id: 13616:MSX2
uniprot id: F6WWM9
names: Subcellular Location Annotation
messages: Nucleus

13616:RPAP1
gene id: 13616:RPAP1
uniprot id: F6YC25
names: Similarity
messages: Belongs to the RPAP1 family.

13616:COL4A3BP
gene id: 13616:COL4A3BP
uniprot id: A0A5F8GSL3
uniprot id: A0A5F8H2W9
uniprot id: F6UGQ8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

13616:PIGV
gene id: 13616:PIGV
uniprot id: F6SRF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

13616:NOL10
gene id: 13616:NOL10
uniprot id: A0A5F8GGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

13616:LOC100023218
gene id: 13616:LOC100023218
uniprot id: A0A5F8GB64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PTPRK
gene id: 13616:PTPRK
uniprot id: A0A5F8GSG5
uniprot id: F6YJV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

13616:B4GALNT2
gene id: 13616:B4GALNT2
uniprot id: F6YH79
uniprot id: K7E359
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

13616:GON4L
gene id: 13616:GON4L
uniprot id: F6QF38
names: Subcellular Location Annotation
messages: Nucleus

13616:TMEM50A
gene id: 13616:TMEM50A
uniprot id: A0A5F8HDH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

13616:SIAH1
gene id: 13616:SIAH1
uniprot id: F7DC68
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

13616:LOC100013048
gene id: 13616:LOC100013048
uniprot id: F7F0U2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:TMPRSS11D
gene id: 13616:TMPRSS11D
uniprot id: F7A010
names: Subcellular Location Annotation
messages: Membrane

13616:HEXB
gene id: 13616:HEXB
uniprot id: F6S6D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

13616:CDKN1A
gene id: 13616:CDKN1A
uniprot id: F7D6Q4
names: Similarity
messages: Belongs to the CDI family.

13616:GPN3
gene id: 13616:GPN3
uniprot id: F6UGC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

13616:SLC20A2
gene id: 13616:SLC20A2
uniprot id: A0A5F8GED8
uniprot id: F7D7N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

13616:GDI2
gene id: 13616:GDI2
uniprot id: F7B3M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

13616:TARSL2
gene id: 13616:TARSL2
uniprot id: F7DDV7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

13616:PTCH1
gene id: 13616:PTCH1
uniprot id: A0A5F8GXF9
uniprot id: F6YGY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

13616:PNO1
gene id: 13616:PNO1
uniprot id: F7G112
names: Similarity
messages: Belongs to the PNO1 family.

13616:LOC100027243
gene id: 13616:LOC100027243
uniprot id: F7CWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

13616:ADRA2B
gene id: 13616:ADRA2B
uniprot id: F7G5U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

13616:TBPL2
gene id: 13616:TBPL2
uniprot id: F7GB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

13616:LOC100019585
gene id: 13616:LOC100019585
uniprot id: F7EEE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TRIAP1
gene id: 13616:TRIAP1
uniprot id: F6WE13
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

13616:SET
gene id: 13616:SET
uniprot id: F7AFN2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

13616:OSBPL9
gene id: 13616:OSBPL9
uniprot id: A0A5F8GHN5
uniprot id: A0A5F8GUV3
uniprot id: F7F7Y5
names: Similarity
messages: Belongs to the OSBP family.

13616:FBXO31
gene id: 13616:FBXO31
uniprot id: A0A5F8G954
uniprot id: A0A5F8GEG3
uniprot id: F6V9B7
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

13616:GRM3
gene id: 13616:GRM3
uniprot id: F6V5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

13616:CDC123
gene id: 13616:CDC123
uniprot id: A0A5F8GMB0
uniprot id: F6R2R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

13616:PSMC4
gene id: 13616:PSMC4
uniprot id: F6Y9A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

13616:EDNRB
gene id: 13616:EDNRB
uniprot id: F7F4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KPNA5
gene id: 13616:KPNA5
uniprot id: A0A5F8HEX0
uniprot id: F6ZXA8
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:LOC100025159
gene id: 13616:LOC100025159
uniprot id: F6UKU7
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

13616:GALNT14
gene id: 13616:GALNT14
uniprot id: A0A5F8GTV4
uniprot id: F6VYP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:ITGA4
gene id: 13616:ITGA4
uniprot id: F6R3Z0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100017736
gene id: 13616:LOC100017736
uniprot id: F6TI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

13616:LOC100024446
gene id: 13616:LOC100024446
uniprot id: A0A5F8GFR1
uniprot id: F7AYT6
names: Subcellular Location Annotation
messages: nucleoplasm

13616:PPIP5K2
gene id: 13616:PPIP5K2
uniprot id: F6RZB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

13616:LOC100015106
gene id: 13616:LOC100015106
uniprot id: F6SRQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EVX1
gene id: 13616:EVX1
uniprot id: F6USZ9
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100017292
gene id: 13616:LOC100017292
uniprot id: F6TBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:T2R7A
gene id: 13616:T2R7A
uniprot id: Q2ABA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:ALKBH8
gene id: 13616:ALKBH8
uniprot id: A0A5F8HAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

13616:MMAA
gene id: 13616:MMAA
uniprot id: F6Y622
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

13616:ABHD2
gene id: 13616:ABHD2
uniprot id: F6R853
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

13616:TBC1D7
gene id: 13616:TBC1D7
uniprot id: F7DPC6
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

13616:NAPEPLD
gene id: 13616:NAPEPLD
uniprot id: F6WYD3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

13616:EIF4H
gene id: 13616:EIF4H
uniprot id: A0A5F8G8Y9
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

13616:NXF1
gene id: 13616:NXF1
uniprot id: F6YJ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

13616:SNX21
gene id: 13616:SNX21
uniprot id: F6ST07
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

13616:CLDN11
gene id: 13616:CLDN11
uniprot id: F7GIS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:LOC100015820
gene id: 13616:LOC100015820
uniprot id: F6V2C5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

13616:PDS5A
gene id: 13616:PDS5A
uniprot id: F7AQ10
names: Similarity
messages: Belongs to the PDS5 family.

13616:LOC100013946
gene id: 13616:LOC100013946
uniprot id: F7D009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

13616:GTPBP1
gene id: 13616:GTPBP1
uniprot id: A0A5F8G323
uniprot id: F6RR07
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

13616:VN2R544
gene id: 13616:VN2R544
uniprot id: F7C9N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:OLFM4
gene id: 13616:OLFM4
uniprot id: A0A5F8H6X6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SLC39A12
gene id: 13616:SLC39A12
uniprot id: A0A5F8GNW9
uniprot id: F6QTS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

13616:HPSE
gene id: 13616:HPSE
uniprot id: F6RYL5
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

13616:KDM5A
gene id: 13616:KDM5A
uniprot id: A0A5F8HAH0
uniprot id: F6QU82
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

13616:KCNT2
gene id: 13616:KCNT2
uniprot id: A0A5F8GKY4
uniprot id: F6YGT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CCNH
gene id: 13616:CCNH
uniprot id: A0A5F8G4C0
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

13616:VN2R650
gene id: 13616:VN2R650
uniprot id: A0A5F8HAF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CYSTM1
gene id: 13616:CYSTM1
uniprot id: A0A5F8GUQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

13616:TRAPPC3L
gene id: 13616:TRAPPC3L
uniprot id: A0A5F8H9I1
uniprot id: F6Z8A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

13616:SLC25A40
gene id: 13616:SLC25A40
uniprot id: A0A5F8G986
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

13616:LOC100019935
gene id: 13616:LOC100019935
uniprot id: A0A5F8GK22
names: Similarity
messages: Belongs to the acylphosphatase family.

13616:LOC100020486
gene id: 13616:LOC100020486
uniprot id: A0A5F8H8W5
uniprot id: F6ZXR8
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

13616:LOC100025071
gene id: 13616:LOC100025071
uniprot id: F7GI68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LTB
gene id: 13616:LTB
uniprot id: F6Z4T6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:CDH9
gene id: 13616:CDH9
uniprot id: F6UBJ7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:TEAD1
gene id: 13616:TEAD1
uniprot id: A0A5F8G5Y2
uniprot id: A0A5F8G6L0
uniprot id: A0A5F8GT60
uniprot id: F7F1L8
names: Subcellular Location Annotation
messages: Nucleus

13616:GRPR
gene id: 13616:GRPR
uniprot id: F6XXP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RHOT2
gene id: 13616:RHOT2
uniprot id: F7BZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

13616:ME3
gene id: 13616:ME3
uniprot id: A0A5F8GP42
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

13616:SPDL1
gene id: 13616:SPDL1
uniprot id: F6UEJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

13616:FZD2
gene id: 13616:FZD2
uniprot id: F6RKF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:FBXO34
gene id: 13616:FBXO34
uniprot id: A0A5F8G972
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

13616:ATP2C2
gene id: 13616:ATP2C2
uniprot id: F6ULX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:EBP
gene id: 13616:EBP
uniprot id: F6W675
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:VN2R563
gene id: 13616:VN2R563
uniprot id: A0A5F8H813
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CLDN25
gene id: 13616:CLDN25
uniprot id: F6U6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

13616:monDomV1R1238
gene id: 13616:monDomV1R1238
uniprot id: A0A5F8H815
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SMPDL3A
gene id: 13616:SMPDL3A
uniprot id: F7EL84
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

13616:PRRX1
gene id: 13616:PRRX1
uniprot id: A0A5F8GML0
uniprot id: F7FQ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

13616:ENY2
gene id: 13616:ENY2
uniprot id: A0A5F8GG68
uniprot id: A0A5F8GYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

13616:LOC100027100
gene id: 13616:LOC100027100
uniprot id: F6UKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TTR
gene id: 13616:TTR
uniprot id: P49141
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transthyretin family.
messages: Detected in plasma and cerebrospinal fluid (at protein level). Highly expressed in the choroid plexus. Detected in liver.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

13616:NUP155
gene id: 13616:NUP155
uniprot id: F7FWK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

13616:SFT2D2
gene id: 13616:SFT2D2
uniprot id: A0A5F8HCC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

13616:PGM2L1
gene id: 13616:PGM2L1
uniprot id: F7B0Q5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

13616:CNR2
gene id: 13616:CNR2
uniprot id: F7CMJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GRK1
gene id: 13616:GRK1
uniprot id: F7FA38
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

13616:LOC100023593
gene id: 13616:LOC100023593
uniprot id: F7E0M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TRAF3
gene id: 13616:TRAF3
uniprot id: F7DTX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

13616:LOC100013449
gene id: 13616:LOC100013449
uniprot id: F7FD88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CENPB
gene id: 13616:CENPB
uniprot id: F6WYF8
names: Subcellular Location Annotation
messages: Nucleus

13616:FAM49A
gene id: 13616:FAM49A
uniprot id: F6ZPT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

13616:PPP1R1B
gene id: 13616:PPP1R1B
uniprot id: F6S0P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

13616:LOC100024874
gene id: 13616:LOC100024874
uniprot id: F6VE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

13616:VN2R630
gene id: 13616:VN2R630
uniprot id: A0A5F8H6H3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:AVP
gene id: 13616:AVP
uniprot id: F7D0Q1
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

13616:TNIP2
gene id: 13616:TNIP2
uniprot id: F7D8K2
names: Subcellular Location Annotation
messages: Cytoplasm

13616:PLD3
gene id: 13616:PLD3
uniprot id: F7FNI6
names: Similarity
messages: Belongs to the phospholipase D family.

13616:PIGS
gene id: 13616:PIGS
uniprot id: F6QSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PURG
gene id: 13616:PURG
uniprot id: F7ANE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

13616:SLC25A20
gene id: 13616:SLC25A20
uniprot id: A0A5F8GDJ7
uniprot id: F7DSV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:D2HGDH
gene id: 13616:D2HGDH
uniprot id: F6PH88
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

13616:EEF1AKMT1
gene id: 13616:EEF1AKMT1
uniprot id: F6ZYG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

13616:MED22
gene id: 13616:MED22
uniprot id: F6T0Z7
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

13616:CASQ1
gene id: 13616:CASQ1
uniprot id: F6QTC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

13616:PSMB10
gene id: 13616:PSMB10
uniprot id: F7FVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:SLC7A10
gene id: 13616:SLC7A10
uniprot id: F7CE83
names: Subcellular Location Annotation
messages: Membrane

13616:INO80C
gene id: 13616:INO80C
uniprot id: F6Y650
names: Subcellular Location Annotation
messages: Nucleus

13616:BPNT1
gene id: 13616:BPNT1
uniprot id: A0A5F8GZC1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:TGFBI
gene id: 13616:TGFBI
uniprot id: F7D796
names: Subcellular Location Annotation
messages: extracellular matrix

13616:RTCB
gene id: 13616:RTCB
uniprot id: F7BCY1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

13616:E2F3
gene id: 13616:E2F3
uniprot id: F6WI20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:BRMS1L
gene id: 13616:BRMS1L
uniprot id: F6T0C6
names: Subcellular Location Annotation
messages: Nucleus

13616:DUSP5
gene id: 13616:DUSP5
uniprot id: A0A5F8GZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

13616:LOC100014880
gene id: 13616:LOC100014880
uniprot id: F6Z1Q5
names: Subcellular Location Annotation
messages: Membrane

13616:LMOD1
gene id: 13616:LMOD1
uniprot id: F6Y639
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

13616:CORO2B
gene id: 13616:CORO2B
uniprot id: F7CQ44
names: Similarity
messages: Belongs to the WD repeat coronin family.

13616:NPM3
gene id: 13616:NPM3
uniprot id: F7GE61
names: Similarity
messages: Belongs to the nucleoplasmin family.

13616:DRD5
gene id: 13616:DRD5
uniprot id: F7APR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FGF11
gene id: 13616:FGF11
uniprot id: A0A5F8GP66
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:VGLL4
gene id: 13616:VGLL4
uniprot id: A0A5F8GE78
uniprot id: A0A5F8GG28
uniprot id: A0A5F8H2D1
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

13616:ELOVL7
gene id: 13616:ELOVL7
uniprot id: F6QM63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

13616:LOC100017630
gene id: 13616:LOC100017630
uniprot id: F7F7L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:LOC100030208
gene id: 13616:LOC100030208
uniprot id: A0A5F8H4V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TNPO2
gene id: 13616:TNPO2
uniprot id: F6PVQ1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:IRF2BP2
gene id: 13616:IRF2BP2
uniprot id: F7GEJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

13616:GIMAP6
gene id: 13616:GIMAP6
uniprot id: A0A5F8H098
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:VN2R557
gene id: 13616:VN2R557
uniprot id: A0A5F8GBK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ZFYVE28
gene id: 13616:ZFYVE28
uniprot id: F7AES7
names: Similarity
messages: Belongs to the lst-2 family.

13616:THEMIS2
gene id: 13616:THEMIS2
uniprot id: A0A5F8HEI8
names: Similarity
messages: Belongs to the themis family.

13616:SULF1
gene id: 13616:SULF1
uniprot id: A0A5F8HI11
uniprot id: F7DW81
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:AGPS
gene id: 13616:AGPS
uniprot id: F6YBI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

13616:CCT6A
gene id: 13616:CCT6A
uniprot id: F7BUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:WDFY1
gene id: 13616:WDFY1
uniprot id: F6XE34
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

13616:LOC103100950
gene id: 13616:LOC103100950
uniprot id: A0A5F8G6Q2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

13616:CD320
gene id: 13616:CD320
uniprot id: A0A5F8GZ67
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ADAM33
gene id: 13616:ADAM33
uniprot id: F6UN04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ARTN
gene id: 13616:ARTN
uniprot id: F6Q199
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

13616:TCHP
gene id: 13616:TCHP
uniprot id: F6SVU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCHP family.
messages: cytoskeleton

13616:MAP3K8
gene id: 13616:MAP3K8
uniprot id: F7EA12
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

13616:LOC100619788
gene id: 13616:LOC100619788
uniprot id: F7GG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SYVN1
gene id: 13616:SYVN1
uniprot id: F7BYZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CPSF2
gene id: 13616:CPSF2
uniprot id: F6QCB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

13616:PDE6B
gene id: 13616:PDE6B
uniprot id: F6W037
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:JUNB
gene id: 13616:JUNB
uniprot id: A0A5F8GZN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

13616:CHMP2B
gene id: 13616:CHMP2B
uniprot id: F6VMU4
names: Similarity
messages: Belongs to the SNF7 family.

13616:FOXO6
gene id: 13616:FOXO6
uniprot id: F6WVS4
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100022215
gene id: 13616:LOC100022215
uniprot id: F6ZVZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

13616:UCP3
gene id: 13616:UCP3
uniprot id: F7DAU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:C3H18orf32
gene id: 13616:C3H18orf32
uniprot id: F7C7W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

13616:NDUFB11
gene id: 13616:NDUFB11
uniprot id: F7BRP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:SSR3
gene id: 13616:SSR3
uniprot id: F7AHP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

13616:SEZ6L2
gene id: 13616:SEZ6L2
uniprot id: A0A5F8GRA9
uniprot id: A0A5F8GSC4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:UNC45A
gene id: 13616:UNC45A
uniprot id: A0A5F8H8V9
names: Subcellular Location Annotation
messages: perinuclear region

13616:LYRM7
gene id: 13616:LYRM7
uniprot id: F6RYU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

13616:TMEM175
gene id: 13616:TMEM175
uniprot id: A0A5F8H9J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

13616:POLA2
gene id: 13616:POLA2
uniprot id: F6WAX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

13616:IK
gene id: 13616:IK
uniprot id: F6RJP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

13616:THPO
gene id: 13616:THPO
uniprot id: F7G570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

13616:PDGFRB
gene id: 13616:PDGFRB
uniprot id: F6XAD2
names: Subcellular Location Annotation
messages: Membrane

13616:POLR3G
gene id: 13616:POLR3G
uniprot id: F7FXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

13616:KCNE2
gene id: 13616:KCNE2
uniprot id: F7E665
names: Similarity
messages: Belongs to the potassium channel KCNE family.

13616:LOC100012527
gene id: 13616:LOC100012527
uniprot id: F6UY50
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

13616:LOC100012302
gene id: 13616:LOC100012302
uniprot id: F6VZJ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:SNX9
gene id: 13616:SNX9
uniprot id: A0A5F8HCD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

13616:GJA1
gene id: 13616:GJA1
uniprot id: F7E4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:ERH
gene id: 13616:ERH
uniprot id: F6VPB7
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

13616:ZDHHC5
gene id: 13616:ZDHHC5
uniprot id: A0A5F8HGA3
uniprot id: F7EAG3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:PDE2A
gene id: 13616:PDE2A
uniprot id: F7EBA5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:LOC100027301
gene id: 13616:LOC100027301
uniprot id: F7GI23
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

13616:ZEB1
gene id: 13616:ZEB1
uniprot id: A0A5F8G233
uniprot id: F6Y0B4
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

13616:RBP2
gene id: 13616:RBP2
uniprot id: F7BQ22
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:LGR5
gene id: 13616:LGR5
uniprot id: A0A5F8H0S9
uniprot id: F7BZE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RLN3
gene id: 13616:RLN3
uniprot id: A0A5F8GDK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

13616:LOC100619842
gene id: 13616:LOC100619842
uniprot id: F6ZZ92
names: Subcellular Location Annotation
messages: Membrane

13616:PPM1K
gene id: 13616:PPM1K
uniprot id: F6QTI3
names: Similarity
messages: Belongs to the PP2C family.

13616:SCRN1
gene id: 13616:SCRN1
uniprot id: F6XZ29
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

13616:LOC103101367
gene id: 13616:LOC103101367
uniprot id: A0A5F8HG26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

13616:B3GALT1
gene id: 13616:B3GALT1
uniprot id: F7FAR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:UBE2K
gene id: 13616:UBE2K
uniprot id: F7AQ16
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:CDK7
gene id: 13616:CDK7
uniprot id: F6TC82
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

13616:RPL24
gene id: 13616:RPL24
uniprot id: F6W129
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

13616:CRX
gene id: 13616:CRX
uniprot id: A0A5F8GF02
names: Subcellular Location Annotation
messages: Nucleus

13616:VWF
gene id: 13616:VWF
uniprot id: F5XVB7
names: Subcellular Location Annotation
names: Subunit
messages: Multimeric. Interacts with F8.
messages: extracellular matrix

13616:NKX6-3
gene id: 13616:NKX6-3
uniprot id: F6YT06
names: Subcellular Location Annotation
messages: Nucleus

13616:NPY2R
gene id: 13616:NPY2R
uniprot id: F6UCA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ITPK1
gene id: 13616:ITPK1
uniprot id: F7G3M0
names: Similarity
messages: Belongs to the ITPK1 family.

13616:AFAP1L1
gene id: 13616:AFAP1L1
uniprot id: F6XZ22
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in podosome and invadosome formation.
messages: invadopodium
messages: podosome

13616:NAPRT
gene id: 13616:NAPRT
uniprot id: F7CI40
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

13616:AXL
gene id: 13616:AXL
uniprot id: F6VDX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

13616:ENTPD1
gene id: 13616:ENTPD1
uniprot id: A0A5F8H455
uniprot id: F7FL76
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:KIF12
gene id: 13616:KIF12
uniprot id: F7FMT1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:LOC100029152
gene id: 13616:LOC100029152
uniprot id: F7B7Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100011074
gene id: 13616:LOC100011074
uniprot id: F7EGS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PDE7B
gene id: 13616:PDE7B
uniprot id: A0A5F8HFJ1
uniprot id: A0A5F8HHE0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:PLAGL2
gene id: 13616:PLAGL2
uniprot id: A0A5F8GAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

13616:LOC100017167
gene id: 13616:LOC100017167
uniprot id: F6TBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ANAPC11
gene id: 13616:ANAPC11
uniprot id: A0A5F8H6S1
names: Similarity
messages: Belongs to the RING-box family.

13616:TRIM2
gene id: 13616:TRIM2
uniprot id: A0A5F8G5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

13616:LOC100018166
gene id: 13616:LOC100018166
uniprot id: F6Q969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CD9
gene id: 13616:CD9
uniprot id: F7GEM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

13616:SUPT16H
gene id: 13616:SUPT16H
uniprot id: F7BV95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

13616:CMKLR1
gene id: 13616:CMKLR1
uniprot id: A0A5F8GN93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

13616:REEP5
gene id: 13616:REEP5
uniprot id: F7D9H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

13616:SLC26A5
gene id: 13616:SLC26A5
uniprot id: A0A5F8GG90
uniprot id: A0A5F8H0P0
uniprot id: F6TKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.

13616:NT5DC1
gene id: 13616:NT5DC1
uniprot id: F6Z7W4
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

13616:ALCAM
gene id: 13616:ALCAM
uniprot id: A0A5F8G2T3
uniprot id: F7CKB1
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

13616:TOP1
gene id: 13616:TOP1
uniprot id: A0A5F8G979
uniprot id: F6X447
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

13616:HAT1
gene id: 13616:HAT1
uniprot id: F7CAY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

13616:SNX5
gene id: 13616:SNX5
uniprot id: F7BXX6
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

13616:GALNT16
gene id: 13616:GALNT16
uniprot id: F6VPF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:NDUFB10
gene id: 13616:NDUFB10
uniprot id: F7FYS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

13616:DZIP3
gene id: 13616:DZIP3
uniprot id: A0A5F8G6N7
uniprot id: F6U2A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RING-box family.
messages: Cytoplasm

13616:GPC4
gene id: 13616:GPC4
uniprot id: F6QDK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

13616:PRDM15
gene id: 13616:PRDM15
uniprot id: F6SNW9
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100021046
gene id: 13616:LOC100021046
uniprot id: F7ANM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CSNK1D
gene id: 13616:CSNK1D
uniprot id: A0A5F8HEV6
uniprot id: F7FPX9
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:SAP30
gene id: 13616:SAP30
uniprot id: F7GBR9
names: Similarity
messages: Belongs to the SAP30 family.

13616:NUP58
gene id: 13616:NUP58
uniprot id: A0A5F8G4X4
uniprot id: F6PH95
names: Subcellular Location Annotation
messages: nuclear pore complex

13616:C4H21orf59
gene id: 13616:C4H21orf59
uniprot id: F6V188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

13616:CNIH3
gene id: 13616:CNIH3
uniprot id: A0A5F8GMG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

13616:LMOD2
gene id: 13616:LMOD2
uniprot id: F7AK27
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

13616:B3GLCT
gene id: 13616:B3GLCT
uniprot id: F7G0B6
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100025197
gene id: 13616:LOC100025197
uniprot id: A0A5F8GCS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TM9SF2
gene id: 13616:TM9SF2
uniprot id: F7A9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

13616:CCT3
gene id: 13616:CCT3
uniprot id: F6XJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:BICD2
gene id: 13616:BICD2
uniprot id: F6PIY7
names: Similarity
messages: Belongs to the BicD family.

13616:INTS2
gene id: 13616:INTS2
uniprot id: F6X1I7
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

13616:ERRFI1
gene id: 13616:ERRFI1
uniprot id: F7A9H2
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

13616:CLN5
gene id: 13616:CLN5
uniprot id: A0A5F8HFZ6
names: Similarity
messages: Belongs to the CLN5 family.

13616:MRTO4
gene id: 13616:MRTO4
uniprot id: F7BR65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

13616:GJA5
gene id: 13616:GJA5
uniprot id: F7EFL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:OGDH
gene id: 13616:OGDH
uniprot id: F7DSQ0
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

13616:PKN2
gene id: 13616:PKN2
uniprot id: A0A5F8G616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

13616:TNFSF8
gene id: 13616:TNFSF8
uniprot id: F6QMZ0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:HABP4
gene id: 13616:HABP4
uniprot id: F7E764
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:HOXD10
gene id: 13616:HOXD10
uniprot id: F7AWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:TFIP11
gene id: 13616:TFIP11
uniprot id: A4UMC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Nucleus

13616:MYOG
gene id: 13616:MYOG
uniprot id: F6ZFK9
names: Subcellular Location Annotation
messages: Nucleus

13616:MFSD4A
gene id: 13616:MFSD4A
uniprot id: F6T5Y2
names: Subcellular Location Annotation
messages: Membrane

13616:B3GAT1
gene id: 13616:B3GAT1
uniprot id: F7DJX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:ABL2
gene id: 13616:ABL2
uniprot id: F7FED8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:TPM4
gene id: 13616:TPM4
uniprot id: F7GGJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

13616:PPP3CC
gene id: 13616:PPP3CC
uniprot id: F7BLB6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

13616:LOC100011522
gene id: 13616:LOC100011522
uniprot id: F6PX60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:RAB39A
gene id: 13616:RAB39A
uniprot id: F7E803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

13616:LOC100025413
gene id: 13616:LOC100025413
uniprot id: F7FKD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NDUFA5
gene id: 13616:NDUFA5
uniprot id: A0A5F8H5G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:RPRM
gene id: 13616:RPRM
uniprot id: A0A5F8H5N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

13616:PLA2G4E
gene id: 13616:PLA2G4E
uniprot id: A0A5F8GD10
uniprot id: F7E3Q7
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

13616:LOC100019224
gene id: 13616:LOC100019224
uniprot id: A0A5F8G8D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

13616:SF3A1
gene id: 13616:SF3A1
uniprot id: F7DA32
names: Subcellular Location Annotation
messages: Nucleus

13616:RNPS1
gene id: 13616:RNPS1
uniprot id: F7B375
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

13616:MGAT2
gene id: 13616:MGAT2
uniprot id: F6SNS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

13616:DNAJC27
gene id: 13616:DNAJC27
uniprot id: A0A5F8G6K7
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

13616:CDK20
gene id: 13616:CDK20
uniprot id: F6XM60
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100028081
gene id: 13616:LOC100028081
uniprot id: F7C9Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TECPR1
gene id: 13616:TECPR1
uniprot id: F7F2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

13616:GCH1
gene id: 13616:GCH1
uniprot id: F7GE69
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

13616:FCF1
gene id: 13616:FCF1
uniprot id: F7B4X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

13616:ALOX5AP
gene id: 13616:ALOX5AP
uniprot id: F7DAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100014039
gene id: 13616:LOC100014039
uniprot id: F6UNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

13616:LOC100618776
gene id: 13616:LOC100618776
uniprot id: A0A5F8GPS1
names: Similarity
messages: Belongs to the globin family.

13616:UTP23
gene id: 13616:UTP23
uniprot id: F6UDS3
names: Subcellular Location Annotation
messages: nucleolus

13616:ZFPM2
gene id: 13616:ZFPM2
uniprot id: F6YLF5
names: Subcellular Location Annotation
messages: Nucleus

13616:BMP2
gene id: 13616:BMP2
uniprot id: F7GIY5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:CMTM7
gene id: 13616:CMTM7
uniprot id: A0A5F8H0V6
names: Subcellular Location Annotation
messages: Membrane

13616:PROX1
gene id: 13616:PROX1
uniprot id: A0A5F8GR59
uniprot id: F6TZI0
names: Subcellular Location Annotation
messages: Nucleus

13616:ATP6V0C
gene id: 13616:ATP6V0C
uniprot id: A0A5F8GI40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

13616:MRPS24
gene id: 13616:MRPS24
uniprot id: A0A5F8G646
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

13616:MAPKAP1
gene id: 13616:MAPKAP1
uniprot id: F6W7N1
names: Similarity
messages: Belongs to the SIN1 family.

13616:PPP1CB
gene id: 13616:PPP1CB
uniprot id: F7AJD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm

13616:NCL
gene id: 13616:NCL
uniprot id: F7BWB5
names: Subcellular Location Annotation
messages: nucleolus

13616:MSL3
gene id: 13616:MSL3
uniprot id: F6WEX7
names: Subcellular Location Annotation
messages: Nucleus

13616:monDomV1R1226
gene id: 13616:monDomV1R1226
uniprot id: F7F0Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CD247
gene id: 13616:CD247
uniprot id: F7G531
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

13616:TUBB2B
gene id: 13616:TUBB2B
uniprot id: A0A5F8HCT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:SAXO2
gene id: 13616:SAXO2
uniprot id: A0A5F8GKE8
uniprot id: F6WCT9
names: Similarity
messages: Belongs to the FAM154 family.

13616:LOC100030411
gene id: 13616:LOC100030411
uniprot id: F7A7Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TM7SF2
gene id: 13616:TM7SF2
uniprot id: F6X4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

13616:SENP7
gene id: 13616:SENP7
uniprot id: A0A5F8G800
uniprot id: F6V2A6
names: Similarity
messages: Belongs to the peptidase C48 family.

13616:LOC100010036
gene id: 13616:LOC100010036
uniprot id: F6Q228
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100024672
gene id: 13616:LOC100024672
uniprot id: F6TXV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: cytoskeleton

13616:SLC4A4
gene id: 13616:SLC4A4
uniprot id: A0A5F8HEA5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PRR5L
gene id: 13616:PRR5L
uniprot id: F6YHY4
names: Similarity
messages: Belongs to the PROTOR family.

13616:ACTL7B
gene id: 13616:ACTL7B
uniprot id: F6XB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

13616:FASN
gene id: 13616:FASN
uniprot id: F7GKK4
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

13616:DGKQ
gene id: 13616:DGKQ
uniprot id: F6VRH1
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

13616:SIX3
gene id: 13616:SIX3
uniprot id: A0A5F8GZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

13616:TFAP2A
gene id: 13616:TFAP2A
uniprot id: A0A5F8G665
uniprot id: A0A5F8H0X1
uniprot id: F6SSJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

13616:GJB1
gene id: 13616:GJB1
uniprot id: F6SVW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:CAPZA2
gene id: 13616:CAPZA2
uniprot id: Q2QL99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).

13616:TFDP1
gene id: 13616:TFDP1
uniprot id: F7ED92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:ALPI
gene id: 13616:ALPI
uniprot id: F7G4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

13616:LOC100025711
gene id: 13616:LOC100025711
uniprot id: F6Q6I7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:PYCRL
gene id: 13616:PYCRL
uniprot id: F6SQV0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

13616:LOC100030333
gene id: 13616:LOC100030333
uniprot id: F7CX27
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100023663
gene id: 13616:LOC100023663
uniprot id: F6WGJ1
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC103097066
gene id: 13616:LOC103097066
uniprot id: F7FEP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

13616:KIF15
gene id: 13616:KIF15
uniprot id: F6S782
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

13616:ADCY9
gene id: 13616:ADCY9
uniprot id: F7EQQ4
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

13616:LIMK2
gene id: 13616:LIMK2
uniprot id: A0A5F8H5F0
uniprot id: F6QSD0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

13616:BLM
gene id: 13616:BLM
uniprot id: F6RXI0
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

13616:ING3
gene id: 13616:ING3
uniprot id: A0A5F8H7X2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:BAZ1A
gene id: 13616:BAZ1A
uniprot id: A0A5F8GW38
uniprot id: F7G1J7
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100018133
gene id: 13616:LOC100018133
uniprot id: F6V7J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103100557
gene id: 13616:LOC103100557
uniprot id: F6U0U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:KCNK12
gene id: 13616:KCNK12
uniprot id: F7DPG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:FZD10
gene id: 13616:FZD10
uniprot id: A0A5F8HHN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

13616:VN2R552
gene id: 13616:VN2R552
uniprot id: F6WQ56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CCDC103
gene id: 13616:CCDC103
uniprot id: F6WJE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

13616:TMEM170A
gene id: 13616:TMEM170A
uniprot id: A0A5F8G3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

13616:LOC100028564
gene id: 13616:LOC100028564
uniprot id: F7AJW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

13616:CLCN6
gene id: 13616:CLCN6
uniprot id: F7BC48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:RAB11FIP4
gene id: 13616:RAB11FIP4
uniprot id: F6ZI91
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

13616:TMEM39A
gene id: 13616:TMEM39A
uniprot id: F7B771
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

13616:NRM
gene id: 13616:NRM
uniprot id: F7BR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

13616:LOC100024653
gene id: 13616:LOC100024653
uniprot id: A0A5F8H890
uniprot id: F6PZH1
names: Similarity
messages: Belongs to the serpin family.

13616:TMEM242
gene id: 13616:TMEM242
uniprot id: F6SWN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

13616:TAF13
gene id: 13616:TAF13
uniprot id: A0A5F8H889
uniprot id: F7G3P1
names: Subcellular Location Annotation
messages: Nucleus

13616:SNRPC
gene id: 13616:SNRPC
uniprot id: F6VBS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

13616:ZC3H12C
gene id: 13616:ZC3H12C
uniprot id: A0A5F8GYA3
uniprot id: F7E8N8
names: Similarity
messages: Belongs to the ZC3H12 family.

13616:LOC100011527
gene id: 13616:LOC100011527
uniprot id: F7GEA2
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:SDHD
gene id: 13616:SDHD
uniprot id: F6T7B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

13616:UBL3
gene id: 13616:UBL3
uniprot id: A0A5F8GM48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ELOVL2
gene id: 13616:ELOVL2
uniprot id: A0A5F8GU42
uniprot id: A0A5F8GU88
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

13616:ORM1
gene id: 13616:ORM1
uniprot id: F7DTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

13616:LETM1
gene id: 13616:LETM1
uniprot id: A0A5F8GKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:PARP10
gene id: 13616:PARP10
uniprot id: F7A7Q9
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:VWA1
gene id: 13616:VWA1
uniprot id: F7B879
names: Subcellular Location Annotation
messages: Membrane
messages: basement membrane

13616:SPG7
gene id: 13616:SPG7
uniprot id: A0A5F8GN77
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

13616:NMT2
gene id: 13616:NMT2
uniprot id: F6XMS8
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

13616:DMRT2
gene id: 13616:DMRT2
uniprot id: F7GCC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:SNRK
gene id: 13616:SNRK
uniprot id: F6UJD0
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LPL
gene id: 13616:LPL
uniprot id: F6VCX0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

13616:LOC100019150
gene id: 13616:LOC100019150
uniprot id: F7E8I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:POPC1
gene id: 13616:POPC1
uniprot id: Q28464
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

13616:LOC100024047
gene id: 13616:LOC100024047
uniprot id: A0A5F8G9Q1
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

13616:LUM
gene id: 13616:LUM
uniprot id: F6SHS6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

13616:SGO2
gene id: 13616:SGO2
uniprot id: F6PKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

13616:MRPS18B
gene id: 13616:MRPS18B
uniprot id: F6ZQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

13616:RALY
gene id: 13616:RALY
uniprot id: F7EJ60
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

13616:TYMP
gene id: 13616:TYMP
uniprot id: A0A5F8HE47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Homodimer.

13616:LOC100018872
gene id: 13616:LOC100018872
uniprot id: A0A5F8GPL8
names: Similarity
messages: Belongs to the RRM elav family.

13616:DDX4
gene id: 13616:DDX4
uniprot id: F6VDB2
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:TDGF1
gene id: 13616:TDGF1
uniprot id: A0A5F8GQJ1
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TBXA2R
gene id: 13616:TBXA2R
uniprot id: F6W8V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SIX2
gene id: 13616:SIX2
uniprot id: A0A5F8HB46
names: Subcellular Location Annotation
messages: Nucleus

13616:MEGF10
gene id: 13616:MEGF10
uniprot id: F7B542
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PAPPA2
gene id: 13616:PAPPA2
uniprot id: F7CFD6
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MAB21L1
gene id: 13616:MAB21L1
uniprot id: F6TNJ5
names: Similarity
messages: Belongs to the mab-21 family.

13616:LOC100017286
gene id: 13616:LOC100017286
uniprot id: F6PZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DNASE1L2
gene id: 13616:DNASE1L2
uniprot id: A0EQL1
names: Similarity
messages: Belongs to the DNase I family.

13616:SLC12A4
gene id: 13616:SLC12A4
uniprot id: A0A5F8G8Z7
uniprot id: F7BNP3
uniprot id: F7GG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:SLIT2
gene id: 13616:SLIT2
uniprot id: A0A5F8GGU6
uniprot id: A0A5F8GUJ9
uniprot id: A0A5F8GZY7
uniprot id: F6W5I6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:GRAP2
gene id: 13616:GRAP2
uniprot id: F7BQB2
uniprot id: F7BQD1
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

13616:GPT
gene id: 13616:GPT
uniprot id: F7AQB9
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

13616:BRI3
gene id: 13616:BRI3
uniprot id: A0A5F8HI27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

13616:COPB2
gene id: 13616:COPB2
uniprot id: F7BQ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

13616:KYNU
gene id: 13616:KYNU
uniprot id: F6Q3X0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:B3GALT2
gene id: 13616:B3GALT2
uniprot id: F6RD08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:CACUL1
gene id: 13616:CACUL1
uniprot id: A0A5F8GET1
names: Similarity
messages: Belongs to the cullin family.

13616:NDP
gene id: 13616:NDP
uniprot id: A0A5F8G428
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:TXNL4A
gene id: 13616:TXNL4A
uniprot id: A0A5F8H5Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

13616:KAT5
gene id: 13616:KAT5
uniprot id: F7AWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

13616:STX2
gene id: 13616:STX2
uniprot id: A0A5F8GFK4
uniprot id: A0A5F8GGV0
uniprot id: F6ZTR8
names: Similarity
messages: Belongs to the syntaxin family.

13616:LOC100014035
gene id: 13616:LOC100014035
uniprot id: F6Z024
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

13616:LOC100021807
gene id: 13616:LOC100021807
uniprot id: F6X027
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100019123
gene id: 13616:LOC100019123
uniprot id: F7BUJ2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

13616:SEC24C
gene id: 13616:SEC24C
uniprot id: A0A5F8HF40
uniprot id: F6RUF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

13616:BCAS2
gene id: 13616:BCAS2
uniprot id: F6R986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

13616:ZDHHC22
gene id: 13616:ZDHHC22
uniprot id: F7G5M0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:TLX1
gene id: 13616:TLX1
uniprot id: F7EGZ4
names: Subcellular Location Annotation
messages: Nucleus

13616:RACK1
gene id: 13616:RACK1
uniprot id: F6VVG7
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

13616:LPAR1
gene id: 13616:LPAR1
uniprot id: F7DRX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

13616:ACSF3
gene id: 13616:ACSF3
uniprot id: F7DU27
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:FZD6
gene id: 13616:FZD6
uniprot id: F7CZ56
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:MICAL2
gene id: 13616:MICAL2
uniprot id: F7CXM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

13616:LOC100030002
gene id: 13616:LOC100030002
uniprot id: A0A5F8H7Q2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:IRAK2
gene id: 13616:IRAK2
uniprot id: F7AID5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

13616:SSH2
gene id: 13616:SSH2
uniprot id: A0A5F8H656
uniprot id: A0A5F8HD36
uniprot id: F6SH18
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

13616:PPP2R4
gene id: 13616:PPP2R4
uniprot id: F7CXG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:B3GALT4
gene id: 13616:B3GALT4
uniprot id: F6X7H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:GABPA
gene id: 13616:GABPA
uniprot id: F6QZT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:SLC6A17
gene id: 13616:SLC6A17
uniprot id: F6WZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:METTL4
gene id: 13616:METTL4
uniprot id: F7GDI0
names: Similarity
messages: Belongs to the MT-A70-like family.

13616:LOC100026094
gene id: 13616:LOC100026094
uniprot id: A0A5F8G4P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

13616:LOC100020543
gene id: 13616:LOC100020543
uniprot id: A0A5F8HEI6
uniprot id: F7E8W9
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:AMIGO1
gene id: 13616:AMIGO1
uniprot id: F6TWW3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

13616:DPY30
gene id: 13616:DPY30
uniprot id: A0A5F8GVZ3
names: Similarity
messages: Belongs to the dpy-30 family.

13616:PLA2G12A
gene id: 13616:PLA2G12A
uniprot id: F6WX38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

13616:CWC25
gene id: 13616:CWC25
uniprot id: F6WUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

13616:P4HB
gene id: 13616:P4HB
uniprot id: F6Q3U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

13616:DACT1
gene id: 13616:DACT1
uniprot id: F7ELJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

13616:LOC100012815
gene id: 13616:LOC100012815
uniprot id: A0A5F8GB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC27A5
gene id: 13616:SLC27A5
uniprot id: K7E5H1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:INPP1
gene id: 13616:INPP1
uniprot id: F6XX24
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:GNRH1
gene id: 13616:GNRH1
uniprot id: F7CI22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

13616:FBXL5
gene id: 13616:FBXL5
uniprot id: F6YQZ8
names: Subcellular Location Annotation
messages: perinuclear region

13616:PCID2
gene id: 13616:PCID2
uniprot id: F7G9F9
names: Similarity
messages: Belongs to the CSN12 family.

13616:CD163
gene id: 13616:CD163
uniprot id: F7ENX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VEZT
gene id: 13616:VEZT
uniprot id: A0A5F8HBR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

13616:TSPAN11
gene id: 13616:TSPAN11
uniprot id: F6PSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:SUSD3
gene id: 13616:SUSD3
uniprot id: A0A5F8GKN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ITGB6
gene id: 13616:ITGB6
uniprot id: F6ZCH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

13616:SPAST
gene id: 13616:SPAST
uniprot id: A0A5F8HE08
uniprot id: F6WWB5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

13616:BIVM
gene id: 13616:BIVM
uniprot id: F6SAK9
names: Similarity
messages: Belongs to the BIVM family.

13616:SPAG7
gene id: 13616:SPAG7
uniprot id: F6YNM5
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC41A1
gene id: 13616:SLC41A1
uniprot id: F6SNK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

13616:LOC100014708
gene id: 13616:LOC100014708
uniprot id: A0A5F8GF32
uniprot id: F7EFJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

13616:SEC22A
gene id: 13616:SEC22A
uniprot id: F6PSR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

13616:NELFE
gene id: 13616:NELFE
uniprot id: F7FHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

13616:H3F3B
gene id: 13616:H3F3B
uniprot id: A0A5F8GJ95
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:DPT
gene id: 13616:DPT
uniprot id: A0A5F8G6P1
names: Similarity
messages: Belongs to the dermatopontin family.

13616:ATPAF1
gene id: 13616:ATPAF1
uniprot id: F6W119
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

13616:PRKD3
gene id: 13616:PRKD3
uniprot id: F7FGD2
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

13616:CACNB4
gene id: 13616:CACNB4
uniprot id: A0A5F8HB94
uniprot id: A0A5F8HIV3
uniprot id: B6IDG2
uniprot id: F6Q927
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

13616:RBBP4
gene id: 13616:RBBP4
uniprot id: F7AJD6
names: Subcellular Location Annotation
messages: Nucleus

13616:CTSK
gene id: 13616:CTSK
uniprot id: A0A5F8H101
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted

13616:HDHD3
gene id: 13616:HDHD3
uniprot id: F6X2M1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

13616:ATP2A2
gene id: 13616:ATP2A2
uniprot id: A0A5F8H2Z6
uniprot id: F7GE81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

13616:LOC100027495
gene id: 13616:LOC100027495
uniprot id: F6PJD6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

13616:TDRD9
gene id: 13616:TDRD9
uniprot id: F6VF39
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

13616:HGF
gene id: 13616:HGF
uniprot id: A0A5F8GFC6
uniprot id: F6Y0F0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

13616:LOC100010167
gene id: 13616:LOC100010167
uniprot id: F7DY38
names: Subcellular Location Annotation
messages: Membrane

13616:ZHX1
gene id: 13616:ZHX1
uniprot id: F6QW83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

13616:RBM47
gene id: 13616:RBM47
uniprot id: A0A5F8GKK9
uniprot id: F7BKF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

13616:CRYBB1
gene id: 13616:CRYBB1
uniprot id: F7G7F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

13616:ABLIM1
gene id: 13616:ABLIM1
uniprot id: A0A5F8HEZ9
names: Subcellular Location Annotation
messages: Cytoplasm

13616:INO80
gene id: 13616:INO80
uniprot id: F6TFW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

13616:INSIG1
gene id: 13616:INSIG1
uniprot id: F6US22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

13616:KIF20A
gene id: 13616:KIF20A
uniprot id: F7CE67
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:BBS7
gene id: 13616:BBS7
uniprot id: F7GJV3
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

13616:TBX22
gene id: 13616:TBX22
uniprot id: F6TW49
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:BORCS5
gene id: 13616:BORCS5
uniprot id: A0A5F8H5A0
uniprot id: F6PG67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

13616:KITLG
gene id: 13616:KITLG
uniprot id: A0A5F8G474
uniprot id: A0A5F8GDP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

13616:PSD2
gene id: 13616:PSD2
uniprot id: F7CW81
names: Subcellular Location Annotation
messages: ruffle membrane

13616:CCT5
gene id: 13616:CCT5
uniprot id: F7GDM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:IMPAD1
gene id: 13616:IMPAD1
uniprot id: F7G2D4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:ATP5H
gene id: 13616:ATP5H
uniprot id: A0A5F8GEJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

13616:LOC100027666
gene id: 13616:LOC100027666
uniprot id: F7CMU3
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

13616:TUBB
gene id: 13616:TUBB
uniprot id: F7F082
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:SDE2
gene id: 13616:SDE2
uniprot id: F6VZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

13616:LOC100028437
gene id: 13616:LOC100028437
uniprot id: F7FJF7
names: Similarity
messages: Belongs to the CFAP43 family.

13616:TPD52L1
gene id: 13616:TPD52L1
uniprot id: A0A5F8GX98
uniprot id: A0A5F8H9E8
names: Similarity
messages: Belongs to the TPD52 family.

13616:SFT2D1
gene id: 13616:SFT2D1
uniprot id: F6TJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

13616:VLDLR
gene id: 13616:VLDLR
uniprot id: A0A5F8GS69
uniprot id: F7BMW3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: clathrin-coated pit

13616:LOC100013732
gene id: 13616:LOC100013732
uniprot id: F6X525
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

13616:MS4A5
gene id: 13616:MS4A5
uniprot id: A0A5F8G948
names: Similarity
messages: Belongs to the MS4A family.

13616:MRPL18
gene id: 13616:MRPL18
uniprot id: F7EDX2
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

13616:HSCB
gene id: 13616:HSCB
uniprot id: F7BVB0
names: Similarity
messages: Belongs to the HscB family.

13616:SART3
gene id: 13616:SART3
uniprot id: F6UVE9
names: Subcellular Location Annotation
messages: nucleoplasm

13616:POMC
gene id: 13616:POMC
uniprot id: Q95J84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

13616:CNOT8
gene id: 13616:CNOT8
uniprot id: F6PHB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

13616:TPK1
gene id: 13616:TPK1
uniprot id: A0A5F8GTE9
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

13616:ERMAP
gene id: 13616:ERMAP
uniprot id: F6QE42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

13616:SPHKAP
gene id: 13616:SPHKAP
uniprot id: A0A5F8GXF6
uniprot id: F6UG18
names: Similarity
messages: Belongs to the AKAP110 family.

13616:PHKG1
gene id: 13616:PHKG1
uniprot id: A0A5F8H1W5
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

13616:LOC100032987
gene id: 13616:LOC100032987
uniprot id: F7G3B9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PLA2G15
gene id: 13616:PLA2G15
uniprot id: F7EQG0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

13616:NIPAL4
gene id: 13616:NIPAL4
uniprot id: F7BV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:LHX3
gene id: 13616:LHX3
uniprot id: F7E0Z8
names: Subcellular Location Annotation
messages: Nucleus

13616:HHEX
gene id: 13616:HHEX
uniprot id: F7EGI1
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100024791
gene id: 13616:LOC100024791
uniprot id: F7F1D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100032028
gene id: 13616:LOC100032028
uniprot id: F6SPU8
names: Similarity
messages: Belongs to the PRORSD1 family.

13616:EGFL6
gene id: 13616:EGFL6
uniprot id: F6WWJ4
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:FAM131C
gene id: 13616:FAM131C
uniprot id: A0A5F8HLV3
names: Similarity
messages: Belongs to the FAM131 family.

13616:PDCL
gene id: 13616:PDCL
uniprot id: A0A5F8H8X0
names: Similarity
messages: Belongs to the phosducin family.

13616:QSOX1
gene id: 13616:QSOX1
uniprot id: A0A5F8GCP6
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

13616:ZFYVE16
gene id: 13616:ZFYVE16
uniprot id: F6SG91
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

13616:GDF10
gene id: 13616:GDF10
uniprot id: F6UZ74
names: Similarity
messages: Belongs to the TGF-beta family.

13616:ENGASE
gene id: 13616:ENGASE
uniprot id: F6QW59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

13616:FAM32A
gene id: 13616:FAM32A
uniprot id: F7G6F7
names: Similarity
messages: Belongs to the FAM32 family.

13616:SLC18A1
gene id: 13616:SLC18A1
uniprot id: F6WAQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

13616:monDomV1R1202
gene id: 13616:monDomV1R1202
uniprot id: A0A5F8H1L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EEF2
gene id: 13616:EEF2
uniprot id: F6T8K7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

13616:FAN1
gene id: 13616:FAN1
uniprot id: A0A5F8HHL9
uniprot id: F7CBU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

13616:SLC6A1
gene id: 13616:SLC6A1
uniprot id: F6SLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:LOC100016303
gene id: 13616:LOC100016303
uniprot id: A0A5F8HH76
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

13616:LOC100022062
gene id: 13616:LOC100022062
uniprot id: A0A5F8G5S9
names: Similarity
messages: Belongs to the SPT2 family.

13616:SIN3B
gene id: 13616:SIN3B
uniprot id: A0A5F8G735
uniprot id: F7CG40
names: Subcellular Location Annotation
messages: Nucleus

13616:KIF24
gene id: 13616:KIF24
uniprot id: A0A5F8GX18
uniprot id: K7E100
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:RAB3C
gene id: 13616:RAB3C
uniprot id: A0A5F8GNN1
uniprot id: F6R8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

13616:SLC39A7
gene id: 13616:SLC39A7
uniprot id: F6T918
names: Subcellular Location Annotation
messages: Membrane

13616:UBE2R2
gene id: 13616:UBE2R2
uniprot id: F7FAJ7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:RARS2
gene id: 13616:RARS2
uniprot id: F6PVI2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:SPO11
gene id: 13616:SPO11
uniprot id: F6X8N3
names: Similarity
messages: Belongs to the TOP6A family.

13616:SLC39A8
gene id: 13616:SLC39A8
uniprot id: F7DLB3
names: Subcellular Location Annotation
messages: Membrane

13616:NDNF
gene id: 13616:NDNF
uniprot id: A0A5F8GTJ5
names: Subcellular Location Annotation
messages: Secreted

13616:C3H19orf25
gene id: 13616:C3H19orf25
uniprot id: A0A5F8GMH4
names: Similarity
messages: Belongs to the UPF0449 family.

13616:NIP7
gene id: 13616:NIP7
uniprot id: F6YGD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

13616:LOC100028416
gene id: 13616:LOC100028416
uniprot id: A0A5F8H1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ORMDL1
gene id: 13616:ORMDL1
uniprot id: A0A5F8GRE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

13616:LOC100011399
gene id: 13616:LOC100011399
uniprot id: F7DNQ9
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:MAEA
gene id: 13616:MAEA
uniprot id: F6WPZ4
names: Subcellular Location Annotation
messages: Nucleus matrix

13616:LOC100618848
gene id: 13616:LOC100618848
uniprot id: F7AKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VAMP4
gene id: 13616:VAMP4
uniprot id: F6ZJ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

13616:CD3G
gene id: 13616:CD3G
uniprot id: F7F8D9
names: Subcellular Location Annotation
messages: Membrane

13616:HOXB1
gene id: 13616:HOXB1
uniprot id: A0A5F8GKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

13616:ESF1
gene id: 13616:ESF1
uniprot id: F7ASI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

13616:SPERT
gene id: 13616:SPERT
uniprot id: A0A5F8GB10
uniprot id: A0A5F8H672
uniprot id: A0A5F8H9W8
uniprot id: A0A5F8HFR0
uniprot id: F7D0F1
names: Similarity
names: Subunit
messages: Belongs to the chibby family. SPERT subfamily.
messages: Homodimer. Binds to NEK1.

13616:LOC100016977
gene id: 13616:LOC100016977
uniprot id: F6ZTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RIC8B
gene id: 13616:RIC8B
uniprot id: F7AMT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

13616:LOC100011677
gene id: 13616:LOC100011677
uniprot id: F6YDH0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

13616:PIGH
gene id: 13616:PIGH
uniprot id: A0A5F8G8T6
names: Similarity
messages: Belongs to the PIGH family.

13616:SGK1
gene id: 13616:SGK1
uniprot id: A0A5F8GZ56
uniprot id: A0A5F8HJ36
uniprot id: F7F0V9
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

13616:MTHFS
gene id: 13616:MTHFS
uniprot id: F6SFK7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

13616:GNPNAT1
gene id: 13616:GNPNAT1
uniprot id: A0A5F8HFP4
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

13616:TMEM205
gene id: 13616:TMEM205
uniprot id: F7FGV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

13616:BDNF
gene id: 13616:BDNF
uniprot id: F7B7D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

13616:LOC100011383
gene id: 13616:LOC100011383
uniprot id: A0A5F8GDX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:ST8SIA3
gene id: 13616:ST8SIA3
uniprot id: F7AQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:CXXC1
gene id: 13616:CXXC1
uniprot id: F6YRK9
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100022649
gene id: 13616:LOC100022649
uniprot id: F7DXU6
names: Function
names: Similarity
messages: Belongs to the calmodulin family.
messages: May be involved in calcium-mediated signal transduction.

13616:TAF4B
gene id: 13616:TAF4B
uniprot id: F7FSG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

13616:NSRP1
gene id: 13616:NSRP1
uniprot id: F6VV70
names: Similarity
messages: Belongs to the NSRP1 family.

13616:PGAP3
gene id: 13616:PGAP3
uniprot id: A0A5F8G5H8
uniprot id: A0A5F8GR43
uniprot id: A0A5F8HKL2
uniprot id: F7DD76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:RCAN3
gene id: 13616:RCAN3
uniprot id: F7EXQ5
names: Similarity
messages: Belongs to the RCAN family.

13616:MFN2
gene id: 13616:MFN2
uniprot id: A0A5F8GXF5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

13616:TRNT1
gene id: 13616:TRNT1
uniprot id: F6W967
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

13616:MRPS11
gene id: 13616:MRPS11
uniprot id: F6Y8U7
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

13616:LOC100024704
gene id: 13616:LOC100024704
uniprot id: A0A5F8H075
uniprot id: F6RFU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

13616:KIFC2
gene id: 13616:KIFC2
uniprot id: F7EP41
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:RPSA
gene id: 13616:RPSA
uniprot id: F7BC17
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

13616:PRKCDBP
gene id: 13616:PRKCDBP
uniprot id: F7FD45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

13616:NAXD
gene id: 13616:NAXD
uniprot id: F6R5B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Mitochondrion

13616:FAM198A
gene id: 13616:FAM198A
uniprot id: F6U3V1
names: Similarity
messages: Belongs to the GASK family.

13616:EARS2
gene id: 13616:EARS2
uniprot id: F7CD53
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

13616:ANTXR2
gene id: 13616:ANTXR2
uniprot id: A0A5F8HLH9
uniprot id: F6S811
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

13616:SIN3A
gene id: 13616:SIN3A
uniprot id: F7BFR8
names: Subcellular Location Annotation
messages: Nucleus

13616:PET117
gene id: 13616:PET117
uniprot id: A0A5F8GKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

13616:PRMT7
gene id: 13616:PRMT7
uniprot id: A0A5F8H4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

13616:LOC100022664
gene id: 13616:LOC100022664
uniprot id: A0A5F8HBE7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100020362
gene id: 13616:LOC100020362
uniprot id: A0A5F8G9D4
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC25A51
gene id: 13616:SLC25A51
uniprot id: F7BG29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100022548
gene id: 13616:LOC100022548
uniprot id: F6SPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CLIC6
gene id: 13616:CLIC6
uniprot id: F6VJL1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

13616:LOC100032458
gene id: 13616:LOC100032458
uniprot id: F6SWW7
uniprot id: F6ZMQ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:CLIC2
gene id: 13616:CLIC2
uniprot id: A0A5F8H1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

13616:MEF2B
gene id: 13616:MEF2B
uniprot id: F6VEY3
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100617288
gene id: 13616:LOC100617288
uniprot id: A0A5F8HBT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:AGA
gene id: 13616:AGA
uniprot id: F6YVD7
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

13616:CUBN
gene id: 13616:CUBN
uniprot id: F6UUU8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

13616:NLK
gene id: 13616:NLK
uniprot id: F6RE45
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

13616:LOC100012766
gene id: 13616:LOC100012766
uniprot id: A0A5F8H1S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FLCN
gene id: 13616:FLCN
uniprot id: F6QGD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

13616:P4HA3
gene id: 13616:P4HA3
uniprot id: F6YZ60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

13616:THOC7
gene id: 13616:THOC7
uniprot id: A0A5F8GWF8
uniprot id: F6Q3G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

13616:PSMB3
gene id: 13616:PSMB3
uniprot id: F6S2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:MAPRE3
gene id: 13616:MAPRE3
uniprot id: A0A5F8GKD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

13616:DGKI
gene id: 13616:DGKI
uniprot id: A0A5F8HIF8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

13616:AMPD3
gene id: 13616:AMPD3
uniprot id: F7E5A8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

13616:MRPL17
gene id: 13616:MRPL17
uniprot id: F6Q774
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

13616:LOC100026015
gene id: 13616:LOC100026015
uniprot id: F7D5P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PDE3A
gene id: 13616:PDE3A
uniprot id: F6YIK3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:SCTR
gene id: 13616:SCTR
uniprot id: F6R8T5
names: Subcellular Location Annotation
messages: Membrane

13616:HTR5A
gene id: 13616:HTR5A
uniprot id: A0A5F8GY28
uniprot id: F7FL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ADGRB1
gene id: 13616:ADGRB1
uniprot id: F6TRV4
names: Subcellular Location Annotation
messages: Membrane

13616:ARL14
gene id: 13616:ARL14
uniprot id: F6XV63
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:SLC25A43
gene id: 13616:SLC25A43
uniprot id: A0A5F8G6H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100013511
gene id: 13616:LOC100013511
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:MIEF1
gene id: 13616:MIEF1
uniprot id: K7E2U5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

13616:CPXM2
gene id: 13616:CPXM2
uniprot id: F6YX02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

13616:LOC100026279
gene id: 13616:LOC100026279
uniprot id: F7A8G2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:USP2
gene id: 13616:USP2
uniprot id: F7EVY5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:LOC100028903
gene id: 13616:LOC100028903
uniprot id: F6T1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

13616:CDC25A
gene id: 13616:CDC25A
uniprot id: F6W4M4
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

13616:REEP1
gene id: 13616:REEP1
uniprot id: A0A5F8GIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

13616:LOC100017350
gene id: 13616:LOC100017350
uniprot id: A0A5F8GHU6
uniprot id: A0A5F8H925
names: Subcellular Location Annotation
messages: Nucleus

13616:FBXO9
gene id: 13616:FBXO9
uniprot id: A0A5F8H7V7
names: Subcellular Location Annotation
messages: Cytoplasm

13616:SPTSSA
gene id: 13616:SPTSSA
uniprot id: A0A5F8GDX5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:ABI2
gene id: 13616:ABI2
uniprot id: A0A5F8G218
uniprot id: A0A5F8GEI6
uniprot id: A0A5F8H605
uniprot id: A0A5F8H9W6
uniprot id: A0A5F8HCI5
uniprot id: F7AYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

13616:CNTN1
gene id: 13616:CNTN1
uniprot id: A0A5F8HEE1
uniprot id: F7C9P7
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

13616:USO1
gene id: 13616:USO1
uniprot id: F7EP84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

13616:GLYATL3
gene id: 13616:GLYATL3
uniprot id: A0A5F8GQX4
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

13616:FBL
gene id: 13616:FBL
uniprot id: F6QP22
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

13616:ADRM1
gene id: 13616:ADRM1
uniprot id: A0A5F8GYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100029519
gene id: 13616:LOC100029519
uniprot id: F6YBH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

13616:MTX2
gene id: 13616:MTX2
uniprot id: F6RZY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

13616:CYR61
gene id: 13616:CYR61
uniprot id: F6WAV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:LIPG
gene id: 13616:LIPG
uniprot id: F7G148
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:TET2
gene id: 13616:TET2
uniprot id: F7FXD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

13616:VN2R616
gene id: 13616:VN2R616
uniprot id: F7D5Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ENPP3
gene id: 13616:ENPP3
uniprot id: F7BSG0
names: Subcellular Location Annotation
messages: Secreted

13616:LOC100013297
gene id: 13616:LOC100013297
uniprot id: F6RS65
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

13616:IL17F
gene id: 13616:IL17F
uniprot id: F6YYQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

13616:KPNA2
gene id: 13616:KPNA2
uniprot id: F7D853
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:NDUFS4
gene id: 13616:NDUFS4
uniprot id: A0A5F8G9C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

13616:NID1
gene id: 13616:NID1
uniprot id: F7FV41
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

13616:LOC100026938
gene id: 13616:LOC100026938
uniprot id: A0A5F8G1S9
names: Subcellular Location Annotation
messages: Membrane

13616:SLITRK5
gene id: 13616:SLITRK5
uniprot id: F6TF48
names: Similarity
messages: Belongs to the SLITRK family.

13616:TBX18
gene id: 13616:TBX18
uniprot id: F6PPW8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:CRYAA
gene id: 13616:CRYAA
uniprot id: F6QYV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

13616:B4GALNT3
gene id: 13616:B4GALNT3
uniprot id: F7DVM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

13616:TSEN34
gene id: 13616:TSEN34
uniprot id: F7F900
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

13616:LOC100022273
gene id: 13616:LOC100022273
uniprot id: F7EJ94
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:SCRN2
gene id: 13616:SCRN2
uniprot id: F6Q4M9
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

13616:GLS2
gene id: 13616:GLS2
uniprot id: F6QBQ6
names: Similarity
messages: Belongs to the glutaminase family.

13616:SAE1
gene id: 13616:SAE1
uniprot id: A0A5F8G607
uniprot id: F7GCP9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

13616:TMEM151B
gene id: 13616:TMEM151B
uniprot id: A0A5F8H4D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

13616:VN2R593
gene id: 13616:VN2R593
uniprot id: F7AZ05
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PGF
gene id: 13616:PGF
uniprot id: F7FF03
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:ACADL
gene id: 13616:ACADL
uniprot id: F7FE37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

13616:LOC100016236
gene id: 13616:LOC100016236
uniprot id: F6RQ67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:KIF3C
gene id: 13616:KIF3C
uniprot id: F7FDX1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:SLITRK2
gene id: 13616:SLITRK2
uniprot id: A0A5F8G8J4
names: Similarity
messages: Belongs to the SLITRK family.

13616:MIPEP
gene id: 13616:MIPEP
uniprot id: F7G4C7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

13616:RELT
gene id: 13616:RELT
uniprot id: F7BLC2
names: Caution
names: Similarity
messages: Belongs to the RELT family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC103093231
gene id: 13616:LOC103093231
uniprot id: A0A5F8H499
uniprot id: F7EY06
names: Similarity
messages: Belongs to the DeSI family.

13616:PLIN1
gene id: 13616:PLIN1
uniprot id: F7B2B5
names: Similarity
messages: Belongs to the perilipin family.

13616:ASF1A
gene id: 13616:ASF1A
uniprot id: A0A5F8H323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

13616:PCMTD1
gene id: 13616:PCMTD1
uniprot id: F6QTB4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

13616:VPS33A
gene id: 13616:VPS33A
uniprot id: F7CE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

13616:FOXJ1
gene id: 13616:FOXJ1
uniprot id: F7FGZ0
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100020089
gene id: 13616:LOC100020089
uniprot id: F7DCB3
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

13616:LOC103099055
gene id: 13616:LOC103099055
uniprot id: A0A5F8HG72
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GPR6
gene id: 13616:GPR6
uniprot id: F6TRX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:USP10
gene id: 13616:USP10
uniprot id: F6Y299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

13616:DDB2
gene id: 13616:DDB2
uniprot id: F6VQA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

13616:CHRM3
gene id: 13616:CHRM3
uniprot id: F6XBA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

13616:FUCA2
gene id: 13616:FUCA2
uniprot id: F6TJX9
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

13616:CPNE4
gene id: 13616:CPNE4
uniprot id: A0A5F8GSJ4
uniprot id: F7GLV8
names: Similarity
messages: Belongs to the copine family.

13616:LOC100018515
gene id: 13616:LOC100018515
uniprot id: F6TIV9
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

13616:DYM
gene id: 13616:DYM
uniprot id: A0A5F8HJW0
uniprot id: F7C8I3
names: Similarity
messages: Belongs to the dymeclin family.

13616:PRRT1
gene id: 13616:PRRT1
uniprot id: F7G653
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:CDCA7
gene id: 13616:CDCA7
uniprot id: F7ADY5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:MARCH11
gene id: 13616:MARCH11
uniprot id: F7DWW8
names: Subcellular Location Annotation
messages: Membrane

13616:VAMP2
gene id: 13616:VAMP2
uniprot id: A0A5F8GDE0
uniprot id: F7A943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

13616:MPC1
gene id: 13616:MPC1
uniprot id: A0A5F8G967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

13616:AHCYL1
gene id: 13616:AHCYL1
uniprot id: F6T5I3
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

13616:MINOS1
gene id: 13616:MINOS1
uniprot id: F7FLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

13616:LIPH
gene id: 13616:LIPH
uniprot id: F6Z6X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

13616:EXTL2
gene id: 13616:EXTL2
uniprot id: F7DWS0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:AP3M1
gene id: 13616:AP3M1
uniprot id: F6VQ35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

13616:LOC100029952
gene id: 13616:LOC100029952
uniprot id: A0A5F8HKJ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:LOC100029725
gene id: 13616:LOC100029725
uniprot id: F6UHH2
names: Similarity
messages: Belongs to the BicD family.

13616:ANKRD34A
gene id: 13616:ANKRD34A
uniprot id: F7EF13
names: Similarity
messages: Belongs to the ANKRD34 family.

13616:SEMA4G
gene id: 13616:SEMA4G
uniprot id: F7B995
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SVOPL
gene id: 13616:SVOPL
uniprot id: A0A5F8GK35
uniprot id: F6SXC8
names: Subcellular Location Annotation
messages: Membrane

13616:SLC26A7
gene id: 13616:SLC26A7
uniprot id: F7GJR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

13616:NDST2
gene id: 13616:NDST2
uniprot id: F6VAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

13616:MGST2
gene id: 13616:MGST2
uniprot id: F6V226
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:IPO7
gene id: 13616:IPO7
uniprot id: F7ETD3
names: Subcellular Location Annotation
messages: Cytoplasm

13616:DPF3
gene id: 13616:DPF3
uniprot id: A0A5F8GE84
uniprot id: A0A5F8GFT4
uniprot id: A0A5F8GGJ7
uniprot id: K7DYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Nucleus

13616:LOC100025981
gene id: 13616:LOC100025981
uniprot id: F7AIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ATG5
gene id: 13616:ATG5
uniprot id: A0A5F8HFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

13616:LOC100618817
gene id: 13616:LOC100618817
uniprot id: F6YMJ4
names: Similarity
messages: Belongs to the globin family.

13616:RAD23A
gene id: 13616:RAD23A
uniprot id: A0A5F8G8H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

13616:MOGS
gene id: 13616:MOGS
uniprot id: F7FL90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

13616:FZD4
gene id: 13616:FZD4
uniprot id: F6VFD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

13616:CALU
gene id: 13616:CALU
uniprot id: A0A5F8HD09
uniprot id: F7F3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

13616:CCR10
gene id: 13616:CCR10
uniprot id: F7CG75
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:IL18R1
gene id: 13616:IL18R1
uniprot id: F7F019
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

13616:KCNMB4
gene id: 13616:KCNMB4
uniprot id: F7C066
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

13616:LOC100021023
gene id: 13616:LOC100021023
uniprot id: F6RPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ARSE
gene id: 13616:ARSE
uniprot id: K7E4E2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:SNX18
gene id: 13616:SNX18
uniprot id: A0A5F8HGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

13616:PPP1R1C
gene id: 13616:PPP1R1C
uniprot id: F6ZGY0
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

13616:COG2
gene id: 13616:COG2
uniprot id: A0A5F8GVG9
names: Similarity
messages: Belongs to the COG2 family.

13616:SSRP1
gene id: 13616:SSRP1
uniprot id: F7ESR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

13616:KIT
gene id: 13616:KIT
uniprot id: F7A906
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:LOC100030289
gene id: 13616:LOC100030289
uniprot id: F7CGB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SMIM15
gene id: 13616:SMIM15
uniprot id: A0A5F8GRU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

13616:LYG1
gene id: 13616:LYG1
uniprot id: F7FWA7
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

13616:RDH10
gene id: 13616:RDH10
uniprot id: F6SH88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:LOC100030370
gene id: 13616:LOC100030370
uniprot id: F6W6I4
names: Similarity
messages: Belongs to the AccD/PCCB family.

13616:RER1
gene id: 13616:RER1
uniprot id: F7G5H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

13616:LOC100027344
gene id: 13616:LOC100027344
uniprot id: A0A5F8G5G3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:TCEB3
gene id: 13616:TCEB3
uniprot id: F7CT40
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC10A6
gene id: 13616:SLC10A6
uniprot id: F6ZZW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

13616:IDH1
gene id: 13616:IDH1
uniprot id: F6ZQM3
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

13616:LOC100029949
gene id: 13616:LOC100029949
uniprot id: F7FSJ3
names: Subcellular Location Annotation
messages: Membrane

13616:PLIN4
gene id: 13616:PLIN4
uniprot id: F7DNE7
names: Similarity
messages: Belongs to the perilipin family.

13616:LOC100617751
gene id: 13616:LOC100617751
uniprot id: F7ENP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:PSME2
gene id: 13616:PSME2
uniprot id: A0A5F8GJ15
names: Similarity
messages: Belongs to the PA28 family.

13616:ARL9
gene id: 13616:ARL9
uniprot id: F7D1G1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:TACR3
gene id: 13616:TACR3
uniprot id: F7E6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PRDX2
gene id: 13616:PRDX2
uniprot id: A0A5F8H055
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

13616:LOC100013717
gene id: 13616:LOC100013717
uniprot id: F7BFQ5
names: Similarity
messages: Belongs to the SNF7 family.

13616:LIX1L
gene id: 13616:LIX1L
uniprot id: F7EF18
names: Similarity
messages: Belongs to the LIX1 family.

13616:RPL27A
gene id: 13616:RPL27A
uniprot id: A0A5F8GDJ6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

13616:CHST2
gene id: 13616:CHST2
uniprot id: F6TJG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

13616:TRPM6
gene id: 13616:TRPM6
uniprot id: A0A5F8HBL9
uniprot id: F6QWI3
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

13616:LOC100012604
gene id: 13616:LOC100012604
uniprot id: Q9XT87
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31.
messages: ISGylated.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

13616:CEPT1
gene id: 13616:CEPT1
uniprot id: A0A5F8GM01
uniprot id: A0A5F8GVL7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

13616:ACTR1A
gene id: 13616:ACTR1A
uniprot id: F6R1W9
names: Similarity
messages: Belongs to the actin family.

13616:LOC100014492
gene id: 13616:LOC100014492
uniprot id: A0A5F8GRQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

13616:LOC100021976
gene id: 13616:LOC100021976
uniprot id: A0A5F8HBA9
names: Subcellular Location Annotation
messages: Nucleus

13616:TMEM144
gene id: 13616:TMEM144
uniprot id: A0A5F8H6Z3
uniprot id: F6VJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

13616:RHO
gene id: 13616:RHO
uniprot id: F7F2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

13616:FES
gene id: 13616:FES
uniprot id: F6RWR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

13616:FOXD1
gene id: 13616:FOXD1
uniprot id: K7E090
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC44A3
gene id: 13616:SLC44A3
uniprot id: A0A5F8HFL5
uniprot id: F6RTY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

13616:LOC100011004
gene id: 13616:LOC100011004
uniprot id: F7E6D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: Membrane
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:SLC2A4
gene id: 13616:SLC2A4
uniprot id: F7G424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

13616:CCNG1
gene id: 13616:CCNG1
uniprot id: A0A5F8G212
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

13616:IMMP2L
gene id: 13616:IMMP2L
uniprot id: F7GH07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ST6GAL2
gene id: 13616:ST6GAL2
uniprot id: E4ZFH5
uniprot id: F7G4K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:CIAO1
gene id: 13616:CIAO1
uniprot id: F7F2Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

13616:RPL18A
gene id: 13616:RPL18A
uniprot id: A0A5F8H1R7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

13616:ITFG1
gene id: 13616:ITFG1
uniprot id: F6ZNY3
names: Similarity
messages: Belongs to the TIP family.

13616:PTN
gene id: 13616:PTN
uniprot id: F6VS98
names: Similarity
messages: Belongs to the pleiotrophin family.

13616:PCOLCE2
gene id: 13616:PCOLCE2
uniprot id: F6TZS0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:LRP12
gene id: 13616:LRP12
uniprot id: A0A5F8G8W0
uniprot id: F7FVQ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VSX2
gene id: 13616:VSX2
uniprot id: F7GCQ9
names: Subcellular Location Annotation
messages: Nucleus

13616:MMS19
gene id: 13616:MMS19
uniprot id: F6VF05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

13616:SLC11A2
gene id: 13616:SLC11A2
uniprot id: F7EQK8
names: Similarity
messages: Belongs to the NRAMP family.

13616:HMCES
gene id: 13616:HMCES
uniprot id: F7E4W2
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

13616:ENKUR
gene id: 13616:ENKUR
uniprot id: A0A5F8GY05
uniprot id: F6PUB7
names: Subcellular Location Annotation
messages: cilium axoneme

13616:SURF1
gene id: 13616:SURF1
uniprot id: F6SJG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion inner membrane

13616:LOC100617279
gene id: 13616:LOC100617279
uniprot id: F7D6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RAB27B
gene id: 13616:RAB27B
uniprot id: A0A5F8GU64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

13616:FLI1
gene id: 13616:FLI1
uniprot id: A0A5F8G6U3
uniprot id: F6WW16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:LOC100018100
gene id: 13616:LOC100018100
uniprot id: F7FPL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

13616:LOC100028170
gene id: 13616:LOC100028170
uniprot id: A0A5F8G805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100031169
gene id: 13616:LOC100031169
uniprot id: F7E1H0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:ARL5A
gene id: 13616:ARL5A
uniprot id: F7FMD0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:EXOC3
gene id: 13616:EXOC3
uniprot id: F6SBJ3
names: Similarity
messages: Belongs to the SEC6 family.

13616:BLK
gene id: 13616:BLK
uniprot id: F7B9H2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:DLGAP4
gene id: 13616:DLGAP4
uniprot id: A0A5F8G958
uniprot id: F7BCR7
names: Similarity
messages: Belongs to the SAPAP family.

13616:FAM214A
gene id: 13616:FAM214A
uniprot id: F6T5P8
names: Similarity
messages: Belongs to the FAM214 family.

13616:CEP70
gene id: 13616:CEP70
uniprot id: F7FRD6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

13616:ANTXR1
gene id: 13616:ANTXR1
uniprot id: F7CVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

13616:KIF22
gene id: 13616:KIF22
uniprot id: F6PIR6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:HCAR1
gene id: 13616:HCAR1
uniprot id: F7EJ84
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:NOG
gene id: 13616:NOG
uniprot id: F7D2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

13616:KIF11
gene id: 13616:KIF11
uniprot id: K7E5Q0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:LOC100025428
gene id: 13616:LOC100025428
uniprot id: F6YZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ARL5B
gene id: 13616:ARL5B
uniprot id: F7FZL7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:UBE2B
gene id: 13616:UBE2B
uniprot id: F6TQE0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:CHST7
gene id: 13616:CHST7
uniprot id: F7AP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

13616:SCARB1
gene id: 13616:SCARB1
uniprot id: A0A5F8G9T3
uniprot id: A0A5F8G9U5
uniprot id: A0A5F8HKB3
names: Similarity
messages: Belongs to the CD36 family.

13616:PPL
gene id: 13616:PPL
uniprot id: F6ZU67
names: Subcellular Location Annotation
messages: cytoskeleton

13616:DDX47
gene id: 13616:DDX47
uniprot id: A0A5F8G9W9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

13616:PLPP1
gene id: 13616:PLPP1
uniprot id: A0A5F8GBD0
uniprot id: F6VUV1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

13616:LOC100019591
gene id: 13616:LOC100019591
uniprot id: F6Z4Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100011978
gene id: 13616:LOC100011978
uniprot id: A0A5F8GZV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:LOC100017088
gene id: 13616:LOC100017088
uniprot id: A0A5F8H6D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:SLC30A9
gene id: 13616:SLC30A9
uniprot id: A0A5F8GK31
uniprot id: A0A5F8GUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Membrane
messages: Nucleus
messages: Vesicle

13616:HOXA2
gene id: 13616:HOXA2
uniprot id: F6TU52
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC103100274
gene id: 13616:LOC103100274
uniprot id: A0A5F8GGQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

13616:SIAH3
gene id: 13616:SIAH3
uniprot id: K7E4P4
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

13616:CDH19
gene id: 13616:CDH19
uniprot id: F7CBY6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:ATG16L1
gene id: 13616:ATG16L1
uniprot id: A0A5F8HCY0
uniprot id: F6ZGZ5
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

13616:ASTE1
gene id: 13616:ASTE1
uniprot id: F7E008
names: Similarity
messages: Belongs to the asteroid family.

13616:GATA5
gene id: 13616:GATA5
uniprot id: F7GG55
names: Subcellular Location Annotation
messages: Nucleus

13616:DEF8
gene id: 13616:DEF8
uniprot id: F7CTD5
names: Similarity
messages: Belongs to the DEF8 family.

13616:TBX2
gene id: 13616:TBX2
uniprot id: F6TQY6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:PITX3
gene id: 13616:PITX3
uniprot id: A0A5F8HBX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:MAPK1
gene id: 13616:MAPK1
uniprot id: F7FHD1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola

13616:MEGF11
gene id: 13616:MEGF11
uniprot id: A0A5F8GGU8
uniprot id: A0A5F8GUM3
uniprot id: A0A5F8HC26
uniprot id: F6SYX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NDUFV3
gene id: 13616:NDUFV3
uniprot id: F6QYY9
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

13616:ARPP19
gene id: 13616:ARPP19
uniprot id: F6T5G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

13616:BMS1
gene id: 13616:BMS1
uniprot id: F7GHE4
names: Subcellular Location Annotation
messages: nucleolus

13616:SPON1
gene id: 13616:SPON1
uniprot id: F7EHN2
names: Subcellular Location Annotation
messages: extracellular matrix

13616:AGTPBP1
gene id: 13616:AGTPBP1
uniprot id: F7DJ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

13616:FGF6
gene id: 13616:FGF6
uniprot id: A0A5F8GPQ2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:MAT1A
gene id: 13616:MAT1A
uniprot id: F7F413
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

13616:TMLHE
gene id: 13616:TMLHE
uniprot id: F7E1P0
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

13616:JAGN1
gene id: 13616:JAGN1
uniprot id: F6ZCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:MYH9
gene id: 13616:MYH9
uniprot id: F7GHW6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:LOC100029547
gene id: 13616:LOC100029547
uniprot id: A0A5F8GN39
names: Similarity
messages: Belongs to the complex I LYR family.

13616:SAXO1
gene id: 13616:SAXO1
uniprot id: F7E7K9
names: Similarity
messages: Belongs to the FAM154 family.

13616:JAKMIP1
gene id: 13616:JAKMIP1
uniprot id: A0A5F8H447
names: Similarity
messages: Belongs to the JAKMIP family.

13616:LOC100617796
gene id: 13616:LOC100617796
uniprot id: F7EB92
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:CLVS2
gene id: 13616:CLVS2
uniprot id: F7ELG1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

13616:SOX3
gene id: 13616:SOX3
uniprot id: F6SCS3
names: Subcellular Location Annotation
messages: Nucleus

13616:PSMG2
gene id: 13616:PSMG2
uniprot id: F7CBG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

13616:LOC100010054
gene id: 13616:LOC100010054
uniprot id: F7EIS0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:TOM1L1
gene id: 13616:TOM1L1
uniprot id: A0A5F8GDB9
uniprot id: F7BYB8
names: Similarity
messages: Belongs to the TOM1 family.

13616:VAMP3
gene id: 13616:VAMP3
uniprot id: F7G4F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

13616:CTC1
gene id: 13616:CTC1
uniprot id: F7EB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

13616:LOC100028614
gene id: 13616:LOC100028614
uniprot id: F7CZ01
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

13616:C3H19orf66
gene id: 13616:C3H19orf66
uniprot id: F7F5S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Nucleus
messages: P-body

13616:TADA3
gene id: 13616:TADA3
uniprot id: F7EQN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

13616:C3H8orf22
gene id: 13616:C3H8orf22
uniprot id: K7E023
names: Similarity
messages: Belongs to the PPDPF family.

13616:LOC100020922
gene id: 13616:LOC100020922
uniprot id: F6STH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:HNRNPDL
gene id: 13616:HNRNPDL
uniprot id: A0A5F8GV62
uniprot id: F7E028
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:RPS12
gene id: 13616:RPS12
uniprot id: F7EIJ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

13616:FOXB1
gene id: 13616:FOXB1
uniprot id: F6XBS2
names: Subcellular Location Annotation
messages: Nucleus

13616:PLA2G2C
gene id: 13616:PLA2G2C
uniprot id: A0A5F8GYW1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

13616:LOC100024341
gene id: 13616:LOC100024341
uniprot id: F6U5A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

13616:SIM2
gene id: 13616:SIM2
uniprot id: A0A5F8HLB5
uniprot id: F6Z9V8
names: Subcellular Location Annotation
messages: Nucleus

13616:BMP5
gene id: 13616:BMP5
uniprot id: F7AD87
names: Similarity
messages: Belongs to the TGF-beta family.

13616:GINS2
gene id: 13616:GINS2
uniprot id: F6Y4K0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

13616:WDFY2
gene id: 13616:WDFY2
uniprot id: F7D654
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

13616:SKA3
gene id: 13616:SKA3
uniprot id: K7DZ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

13616:SLC27A1
gene id: 13616:SLC27A1
uniprot id: F6SCF1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:SHMT1
gene id: 13616:SHMT1
uniprot id: A0A5F8HF15
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

13616:LOC100012393
gene id: 13616:LOC100012393
uniprot id: F7BX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PDIK1L
gene id: 13616:PDIK1L
uniprot id: A0A5F8H7B2
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100619985
gene id: 13616:LOC100619985
uniprot id: F6Z5E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TERF1
gene id: 13616:TERF1
uniprot id: F6XW10
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

13616:LOC100030424
gene id: 13616:LOC100030424
uniprot id: F7GKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TIMP3
gene id: 13616:TIMP3
uniprot id: A0A5F8G917
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with EFEMP1.
messages: extracellular matrix

13616:THUMPD3
gene id: 13616:THUMPD3
uniprot id: F6QGW7
names: Similarity
messages: Belongs to the methyltransferase superfamily.

13616:LOC100025995
gene id: 13616:LOC100025995
uniprot id: F6SJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:RHAG
gene id: 13616:RHAG
uniprot id: F6Z2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

13616:KIF5B
gene id: 13616:KIF5B
uniprot id: F7BJ22
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:IDS
gene id: 13616:IDS
uniprot id: F7DJA1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:LOC100022274
gene id: 13616:LOC100022274
uniprot id: F6Q040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GINS3
gene id: 13616:GINS3
uniprot id: F7GKR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

13616:AHSA1
gene id: 13616:AHSA1
uniprot id: A0A5F8GWY2
names: Similarity
messages: Belongs to the AHA1 family.

13616:ITGA1
gene id: 13616:ITGA1
uniprot id: F6RXG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:SYPL2
gene id: 13616:SYPL2
uniprot id: A0A5F8GSS2
uniprot id: A0A5F8HAB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

13616:monDomV1R1240
gene id: 13616:monDomV1R1240
uniprot id: A0A5F8H930
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MAML1
gene id: 13616:MAML1
uniprot id: F7GAC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

13616:CSK
gene id: 13616:CSK
uniprot id: F7GJZ7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:LOC100024324
gene id: 13616:LOC100024324
uniprot id: F7EID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EGFL7
gene id: 13616:EGFL7
uniprot id: F7AHX7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:POLA1
gene id: 13616:POLA1
uniprot id: F7ADS9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

13616:ADAMTS18
gene id: 13616:ADAMTS18
uniprot id: A0A5F8G1Q7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:T2R2
gene id: 13616:T2R2
uniprot id: Q2ABA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:TTYH2
gene id: 13616:TTYH2
uniprot id: F7DGW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

13616:VN2R527
gene id: 13616:VN2R527
uniprot id: F7EB70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100024120
gene id: 13616:LOC100024120
uniprot id: F7GBZ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LEO1
gene id: 13616:LEO1
uniprot id: F6RIH3
names: Similarity
messages: Belongs to the LEO1 family.

13616:SELL
gene id: 13616:SELL
uniprot id: F6VGS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CTLA4
gene id: 13616:CTLA4
uniprot id: A0A5F8GRC7
uniprot id: F7FLL7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

13616:LOC100015398
gene id: 13616:LOC100015398
uniprot id: A0A5F8GP03
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

13616:LOC100022370
gene id: 13616:LOC100022370
uniprot id: F6Q066
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SBNO2
gene id: 13616:SBNO2
uniprot id: A0A5F8GXV2
uniprot id: A0A5F8HHS8
uniprot id: F7GGH7
names: Similarity
messages: Belongs to the SBNO family.

13616:LOC103097229
gene id: 13616:LOC103097229
uniprot id: A0A5F8H8Y8
uniprot id: K7E577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

13616:RGMB
gene id: 13616:RGMB
uniprot id: F6YFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

13616:CNTNAP4
gene id: 13616:CNTNAP4
uniprot id: A0A5F8H0S4
uniprot id: F6STR1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ARF4
gene id: 13616:ARF4
uniprot id: A0A5F8HGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

13616:SLC25A38
gene id: 13616:SLC25A38
uniprot id: A0A5F8GW97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

13616:SLC16A4
gene id: 13616:SLC16A4
uniprot id: A0A5F8H7G5
names: Subcellular Location Annotation
messages: Membrane

13616:DDX5
gene id: 13616:DDX5
uniprot id: F7ECU0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

13616:SMAD1
gene id: 13616:SMAD1
uniprot id: F6TU68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:DIS3
gene id: 13616:DIS3
uniprot id: F6TF04
names: Similarity
messages: Belongs to the RNR ribonuclease family.

13616:DPY19L4
gene id: 13616:DPY19L4
uniprot id: F6RDC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

13616:TM4SF18
gene id: 13616:TM4SF18
uniprot id: F6T389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:PAQR3
gene id: 13616:PAQR3
uniprot id: F6S7C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:TAGLN3
gene id: 13616:TAGLN3
uniprot id: F7FFS3
names: Similarity
messages: Belongs to the calponin family.

13616:VN2R560
gene id: 13616:VN2R560
uniprot id: A0A5F8G747
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:DCK
gene id: 13616:DCK
uniprot id: F7FN05
names: Similarity
messages: Belongs to the DCK/DGK family.

13616:FAM53A
gene id: 13616:FAM53A
uniprot id: F6X726
names: Similarity
messages: Belongs to the FAM53 family.

13616:BRE
gene id: 13616:BRE
uniprot id: A0A5F8GMC4
uniprot id: F6ZV60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

13616:VPS33B
gene id: 13616:VPS33B
uniprot id: F6VUT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

13616:NUP98
gene id: 13616:NUP98
uniprot id: F7FTZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

13616:TCTEX1D2
gene id: 13616:TCTEX1D2
uniprot id: F6UIA1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

13616:LOC103105270
gene id: 13616:LOC103105270
uniprot id: A0A5F8HKU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

13616:LOC103092739
gene id: 13616:LOC103092739
uniprot id: A0A5F8GWY8
names: Similarity
messages: Belongs to the SELO family.

13616:PARVA
gene id: 13616:PARVA
uniprot id: F7CCU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

13616:RPL10A
gene id: 13616:RPL10A
uniprot id: F6UB55
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

13616:monDomV1R1224
gene id: 13616:monDomV1R1224
uniprot id: F7E1L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CTTNBP2
gene id: 13616:CTTNBP2
uniprot id: F7AH12
names: Subcellular Location Annotation
messages: cell cortex
messages: dendritic spine

13616:GAL3ST2
gene id: 13616:GAL3ST2
uniprot id: F6PHE0
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

13616:C1H9orf116
gene id: 13616:C1H9orf116
uniprot id: F6VAZ1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

13616:PYGB
gene id: 13616:PYGB
uniprot id: A0A5F8GST0
uniprot id: F7EZJ9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

13616:PLA2G1B
gene id: 13616:PLA2G1B
uniprot id: F6VFV8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

13616:MKNK1
gene id: 13616:MKNK1
uniprot id: F6VJP3
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:DLX3
gene id: 13616:DLX3
uniprot id: F7G4K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

13616:WDR12
gene id: 13616:WDR12
uniprot id: F7BGQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

13616:EED
gene id: 13616:EED
uniprot id: F6TW64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

13616:MFAP3L
gene id: 13616:MFAP3L
uniprot id: F6PP60
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:AGPAT5
gene id: 13616:AGPAT5
uniprot id: F7G4Z7
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:TMEM163
gene id: 13616:TMEM163
uniprot id: F6WLI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

13616:ATP5J
gene id: 13616:ATP5J
uniprot id: F6QZT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

13616:SLC1A5
gene id: 13616:SLC1A5
uniprot id: F6QQG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

13616:RDH8
gene id: 13616:RDH8
uniprot id: F7ERI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

13616:NPM2
gene id: 13616:NPM2
uniprot id: A0A5F8GN07
uniprot id: F7D8H7
names: Similarity
messages: Belongs to the nucleoplasmin family.

13616:ECH1
gene id: 13616:ECH1
uniprot id: F6ZM87
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:TET1
gene id: 13616:TET1
uniprot id: F6XCP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

13616:SLC2A6
gene id: 13616:SLC2A6
uniprot id: F7CS72
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:HSPA5
gene id: 13616:HSPA5
uniprot id: F6WMM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

13616:CACNG3
gene id: 13616:CACNG3
uniprot id: F7A5K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

13616:RGS8
gene id: 13616:RGS8
uniprot id: F6PX35
uniprot id: F6PX48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

13616:CCDC172
gene id: 13616:CCDC172
uniprot id: F7A9G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

13616:HHIPL2
gene id: 13616:HHIPL2
uniprot id: F6TQQ8
names: Similarity
messages: Belongs to the HHIP family.

13616:CMTM4
gene id: 13616:CMTM4
uniprot id: F6PVR9
names: Subcellular Location Annotation
messages: Membrane

13616:UBA7
gene id: 13616:UBA7
uniprot id: F6PN80
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

13616:FOLH1B
gene id: 13616:FOLH1B
uniprot id: F7DHV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

13616:NXPH2
gene id: 13616:NXPH2
uniprot id: A0A5F8GZQ8
uniprot id: F7GH77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

13616:ALG11
gene id: 13616:ALG11
uniprot id: F7ESN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

13616:SLC25A26
gene id: 13616:SLC25A26
uniprot id: F6THA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:ATG4C
gene id: 13616:ATG4C
uniprot id: A0A5F8HLB7
uniprot id: F7FIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

13616:ASNA1
gene id: 13616:ASNA1
uniprot id: F6PT29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

13616:PPIL1
gene id: 13616:PPIL1
uniprot id: F7F8D1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:CHAT
gene id: 13616:CHAT
uniprot id: F7ALU3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:C4BPA
gene id: 13616:C4BPA
uniprot id: A0A5F8GCZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CNTNAP1
gene id: 13616:CNTNAP1
uniprot id: F7BXG8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

13616:SLC25A34
gene id: 13616:SLC25A34
uniprot id: F7DWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:UFM1
gene id: 13616:UFM1
uniprot id: F6Y6H3
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

13616:PENK
gene id: 13616:PENK
uniprot id: A0A5F8GKD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

13616:COG8
gene id: 13616:COG8
uniprot id: F6YGC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

13616:LNPEP
gene id: 13616:LNPEP
uniprot id: F6SKQ6
names: Similarity
messages: Belongs to the peptidase M1 family.

13616:MEIS1
gene id: 13616:MEIS1
uniprot id: F6Z0Y6
uniprot id: F7EW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

13616:IRF4
gene id: 13616:IRF4
uniprot id: F7CDR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:LOC100011913
gene id: 13616:LOC100011913
uniprot id: A0A5F8G6Q8
uniprot id: A0A5F8HCQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SLC29A1
gene id: 13616:SLC29A1
uniprot id: A0A5F8GYL0
uniprot id: F7GJP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

13616:PNRC1
gene id: 13616:PNRC1
uniprot id: F6Q6C4
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC6A8
gene id: 13616:SLC6A8
uniprot id: F6Z838
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
messages: Cell membrane
messages: Membrane

13616:PDIA2
gene id: 13616:PDIA2
uniprot id: F7G717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

13616:GPR156
gene id: 13616:GPR156
uniprot id: F6PGM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:CHRM1
gene id: 13616:CHRM1
uniprot id: F7EL12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

13616:SUMF1
gene id: 13616:SUMF1
uniprot id: A0A5F8GW27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

13616:NR3C1
gene id: 13616:NR3C1
uniprot id: F6S9Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

13616:KCNK10
gene id: 13616:KCNK10
uniprot id: A0A5F8GXD9
uniprot id: F7CTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:TMEM9B
gene id: 13616:TMEM9B
uniprot id: F7GAU1
names: Similarity
messages: Belongs to the TMEM9 family.

13616:VN2R519
gene id: 13616:VN2R519
uniprot id: F6ZLJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100026209
gene id: 13616:LOC100026209
uniprot id: F6X7L4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

13616:ACYP1
gene id: 13616:ACYP1
uniprot id: F7AJT1
names: Similarity
messages: Belongs to the acylphosphatase family.

13616:GPAM
gene id: 13616:GPAM
uniprot id: F6S9J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

13616:XPO1
gene id: 13616:XPO1
uniprot id: F7EIW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

13616:C3H5orf63
gene id: 13616:C3H5orf63
uniprot id: F7B4M0
names: Similarity
messages: Belongs to the glutaredoxin family.

13616:NPR3
gene id: 13616:NPR3
uniprot id: F7BZD7
names: Subcellular Location Annotation
messages: Membrane

13616:CLDN5
gene id: 13616:CLDN5
uniprot id: A0A5F8GYS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:LOC100020779
gene id: 13616:LOC100020779
uniprot id: A0A5F8GBN7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

13616:OPN1SW
gene id: 13616:OPN1SW
uniprot id: B9MSR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: photoreceptor outer segment

13616:TTC21B
gene id: 13616:TTC21B
uniprot id: F7EKI1
names: Similarity
messages: Belongs to the TTC21 family.

13616:ATF4
gene id: 13616:ATF4
uniprot id: F7CPU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

13616:DMGDH
gene id: 13616:DMGDH
uniprot id: A0A5F8GYF8
uniprot id: F6X4T1
names: Similarity
messages: Belongs to the GcvT family.

13616:LOC100020606
gene id: 13616:LOC100020606
uniprot id: F6QVX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

13616:PLPP4
gene id: 13616:PLPP4
uniprot id: A0A5F8GBS5
uniprot id: F6PGG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:FAM133B
gene id: 13616:FAM133B
uniprot id: F7FK91
names: Similarity
messages: Belongs to the FAM133 family.

13616:PPIL6
gene id: 13616:PPIL6
uniprot id: A0A5F8G7X9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:ATP6V1A
gene id: 13616:ATP6V1A
uniprot id: F7CCX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

13616:LOC100009916
gene id: 13616:LOC100009916
uniprot id: F6VTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

13616:T2R40
gene id: 13616:T2R40
uniprot id: Q2AB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:SVBP
gene id: 13616:SVBP
uniprot id: A0A5F8GGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

13616:KCND3
gene id: 13616:KCND3
uniprot id: A0A5F8G682
uniprot id: F7CIE1
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

13616:CNNM3
gene id: 13616:CNNM3
uniprot id: F6YUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

13616:VARS2
gene id: 13616:VARS2
uniprot id: F7F0F7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:SEMA6C
gene id: 13616:SEMA6C
uniprot id: F7EDV4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CLPTM1
gene id: 13616:CLPTM1
uniprot id: A0A5F8GPD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

13616:DNASE1L1
gene id: 13616:DNASE1L1
uniprot id: F6RGU8
names: Similarity
messages: Belongs to the DNase I family.

13616:SNRPE
gene id: 13616:SNRPE
uniprot id: K7DZR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

13616:ISL1
gene id: 13616:ISL1
uniprot id: F6QG57
names: Subcellular Location Annotation
messages: Nucleus

13616:NDUFB4
gene id: 13616:NDUFB4
uniprot id: A0A5F8GMT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:AURKB
gene id: 13616:AURKB
uniprot id: A0A5F8HD14
uniprot id: F7ETI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

13616:SHROOM2
gene id: 13616:SHROOM2
uniprot id: F6YLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

13616:BMT2
gene id: 13616:BMT2
uniprot id: A0A5F8GI30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

13616:monDomV1R1265
gene id: 13616:monDomV1R1265
uniprot id: F6V7H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NMNAT2
gene id: 13616:NMNAT2
uniprot id: A0A5F8GHY9
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

13616:EGF
gene id: 13616:EGF
uniprot id: F6R392
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ALX1
gene id: 13616:ALX1
uniprot id: F7F534
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

13616:monDomV1R1258
gene id: 13616:monDomV1R1258
uniprot id: F6Z3N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SKA2
gene id: 13616:SKA2
uniprot id: F6ZDE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

13616:LOC100031103
gene id: 13616:LOC100031103
uniprot id: A0A5F8HCU4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC103097545
gene id: 13616:LOC103097545
uniprot id: F7F1Z4
names: Similarity
messages: Belongs to the Speedy/Ringo family.

13616:LOC100017233
gene id: 13616:LOC100017233
uniprot id: F7BTC7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: gap junction

13616:LLGL1
gene id: 13616:LLGL1
uniprot id: F6Z9W6
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

13616:LOC100030110
gene id: 13616:LOC100030110
uniprot id: K7E501
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HSP90AA1
gene id: 13616:HSP90AA1
uniprot id: F6ZJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

13616:ATP8A2
gene id: 13616:ATP8A2
uniprot id: A0A5F8GX28
uniprot id: F6PFT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:PNPLA4
gene id: 13616:PNPLA4
uniprot id: A0A5F8H039
uniprot id: A0A5F8H674
uniprot id: F7F1B0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SLCO5A1
gene id: 13616:SLCO5A1
uniprot id: F7GKH7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ADRA2C
gene id: 13616:ADRA2C
uniprot id: F7EG22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DEGS1
gene id: 13616:DEGS1
uniprot id: A0A5F8G1N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane

13616:LOC100023204
gene id: 13616:LOC100023204
uniprot id: A0A5F8HK09
uniprot id: F7D0J8
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC103103199
gene id: 13616:LOC103103199
uniprot id: A0A5F8GUZ5
names: Similarity
messages: Belongs to the apolipoprotein L family.

13616:LDLRAD4
gene id: 13616:LDLRAD4
uniprot id: F7B2V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

13616:TMEFF2
gene id: 13616:TMEFF2
uniprot id: F7EGL9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:EIF3M
gene id: 13616:EIF3M
uniprot id: F6YBW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

13616:PRKACA
gene id: 13616:PRKACA
uniprot id: F7G4Q0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

13616:DUOXA1
gene id: 13616:DUOXA1
uniprot id: F7GG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

13616:CDC20B
gene id: 13616:CDC20B
uniprot id: F6RB64
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

13616:LOC100016216
gene id: 13616:LOC100016216
uniprot id: F6VIJ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

13616:F2R
gene id: 13616:F2R
uniprot id: F7BHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ADCY8
gene id: 13616:ADCY8
uniprot id: A0A5F8GL47
uniprot id: F7BCI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:C2H1orf123
gene id: 13616:C2H1orf123
uniprot id: F6URI1
names: Similarity
messages: Belongs to the UPF0587 family.

13616:CARTPT
gene id: 13616:CARTPT
uniprot id: F6T7Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

13616:BDKRB1
gene id: 13616:BDKRB1
uniprot id: F6T0H1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

13616:SIM1
gene id: 13616:SIM1
uniprot id: F7FT81
names: Subcellular Location Annotation
messages: Nucleus

13616:TRPC6
gene id: 13616:TRPC6
uniprot id: A0A5F8GLA7
uniprot id: F6XN03
names: Subcellular Location Annotation
messages: Membrane

13616:LAMTOR2
gene id: 13616:LAMTOR2
uniprot id: F6V5I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

13616:IRAK4
gene id: 13616:IRAK4
uniprot id: F7GD74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

13616:CCNYL1
gene id: 13616:CCNYL1
uniprot id: A0A5F8GSK8
uniprot id: F7FRS8
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

13616:NSUN7
gene id: 13616:NSUN7
uniprot id: F7AYL7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PPP1R16B
gene id: 13616:PPP1R16B
uniprot id: F7BMC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CDC42SE1
gene id: 13616:CDC42SE1
uniprot id: F7GKB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

13616:TBR1
gene id: 13616:TBR1
uniprot id: F6YLI5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:PDP1
gene id: 13616:PDP1
uniprot id: A0A5F8G9W3
uniprot id: A0A5F8GMV6
names: Similarity
messages: Belongs to the PP2C family.

13616:GDAP2
gene id: 13616:GDAP2
uniprot id: F7A1V0
names: Similarity
messages: Belongs to the GDAP2 family.

13616:TEKT2
gene id: 13616:TEKT2
uniprot id: F7GFM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

13616:EDEM3
gene id: 13616:EDEM3
uniprot id: A0A5F8G7R1
uniprot id: F7ADR9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

13616:CLRN3
gene id: 13616:CLRN3
uniprot id: F6PT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

13616:MAT2B
gene id: 13616:MAT2B
uniprot id: A0A5F8GXJ5
uniprot id: F7C5P3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

13616:LOC100013658
gene id: 13616:LOC100013658
uniprot id: F7C2G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100031271
gene id: 13616:LOC100031271
uniprot id: F6RTB1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

13616:OSBPL2
gene id: 13616:OSBPL2
uniprot id: F7D1T6
names: Similarity
messages: Belongs to the OSBP family.

13616:SMAD2
gene id: 13616:SMAD2
uniprot id: F6S0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:DPP4
gene id: 13616:DPP4
uniprot id: F7D0P2
uniprot id: K7DYU6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: invadopodium membrane
messages: lamellipodium membrane

13616:PAPSS1
gene id: 13616:PAPSS1
uniprot id: A0A5F8GR96
uniprot id: A0A5F8H2X0
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

13616:LOC100024932
gene id: 13616:LOC100024932
uniprot id: F6PUC5
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

13616:DLL4
gene id: 13616:DLL4
uniprot id: F6TFF9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

13616:LOC100029967
gene id: 13616:LOC100029967
uniprot id: F6W190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:LOC100032742
gene id: 13616:LOC100032742
uniprot id: F6WPG6
names: Function
messages: May be involved in transcriptional regulation.

13616:C1H14orf166
gene id: 13616:C1H14orf166
uniprot id: F7EW01
names: Similarity
messages: Belongs to the RTRAF family.

13616:SCN3B
gene id: 13616:SCN3B
uniprot id: F7G1T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

13616:SYNJ2
gene id: 13616:SYNJ2
uniprot id: A0A5F8GIJ1
uniprot id: A0A5F8H903
uniprot id: F7AW70
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

13616:IPO9
gene id: 13616:IPO9
uniprot id: F6UA59
names: Subcellular Location Annotation
messages: Cytoplasm

13616:MASTL
gene id: 13616:MASTL
uniprot id: A0A5F8GBQ1
uniprot id: F7B7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

13616:VN2R641
gene id: 13616:VN2R641
uniprot id: F7C1B7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ITM2B
gene id: 13616:ITM2B
uniprot id: F6ZAG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

13616:MCM7
gene id: 13616:MCM7
uniprot id: F6UBM6
uniprot id: K7E231
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

13616:CAB39
gene id: 13616:CAB39
uniprot id: F7D4X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

13616:LOC100017285
gene id: 13616:LOC100017285
uniprot id: F6W7W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

13616:FAM20C
gene id: 13616:FAM20C
uniprot id: F7FTS0
names: Similarity
messages: Belongs to the FAM20 family.

13616:PHYHIPL
gene id: 13616:PHYHIPL
uniprot id: F7EAV9
names: Similarity
messages: Belongs to the PHYHIP family.

13616:CKS1B
gene id: 13616:CKS1B
uniprot id: F6U382
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

13616:MRPL51
gene id: 13616:MRPL51
uniprot id: F7G4E8
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

13616:RPN1
gene id: 13616:RPN1
uniprot id: F6YJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

13616:MED11
gene id: 13616:MED11
uniprot id: A0A5F8GLL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

13616:MOSPD1
gene id: 13616:MOSPD1
uniprot id: A0A5F8HJ15
uniprot id: F7BWH5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

13616:ETV5
gene id: 13616:ETV5
uniprot id: A0A5F8GHC5
uniprot id: F7AAC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:CD68
gene id: 13616:CD68
uniprot id: F6SI34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

13616:MS4A13
gene id: 13616:MS4A13
uniprot id: F7G7B2
names: Similarity
messages: Belongs to the MS4A family.

13616:KEG11 p02
gene id: 13616:KEG11_p02
uniprot id: Q65CI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

13616:KCNK15
gene id: 13616:KCNK15
uniprot id: F7FY32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:LOC100029911
gene id: 13616:LOC100029911
uniprot id: F6Z8E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:XKR5
gene id: 13616:XKR5
uniprot id: F7FM86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

13616:FAM63A
gene id: 13616:FAM63A
uniprot id: F7GKG5
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

13616:RNF141
gene id: 13616:RNF141
uniprot id: F7DJU9
names: Function
messages: May be involved in spermatogenesis.

13616:TMTC3
gene id: 13616:TMTC3
uniprot id: F7EP59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

13616:IL1RL1
gene id: 13616:IL1RL1
uniprot id: F7GDA3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

13616:ACER2
gene id: 13616:ACER2
uniprot id: F6VW29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

13616:MS4A1
gene id: 13616:MS4A1
uniprot id: F7G7B8
names: Similarity
messages: Belongs to the MS4A family.

13616:SBK1
gene id: 13616:SBK1
uniprot id: A0A5F8GK13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

13616:PCSK6
gene id: 13616:PCSK6
uniprot id: F7B8Z0
names: Similarity
messages: Belongs to the peptidase S8 family.

13616:TUSC3
gene id: 13616:TUSC3
uniprot id: A0A5F8GJ85
uniprot id: A0A5F8GM09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CHRNA6
gene id: 13616:CHRNA6
uniprot id: F6WNN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:MFSD1
gene id: 13616:MFSD1
uniprot id: F6RJN0
names: Subcellular Location Annotation
messages: Membrane

13616:THBS2
gene id: 13616:THBS2
uniprot id: F6XY15
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100012785
gene id: 13616:LOC100012785
uniprot id: F7DKQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:LOC100028177
gene id: 13616:LOC100028177
uniprot id: F7E8Y4
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:NODAL
gene id: 13616:NODAL
uniprot id: F7CYQ7
names: Similarity
messages: Belongs to the TGF-beta family.

13616:PIK3C2B
gene id: 13616:PIK3C2B
uniprot id: F7BBM1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

13616:GMPR2
gene id: 13616:GMPR2
uniprot id: F6THE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

13616:RPL32
gene id: 13616:RPL32
uniprot id: A0A5F8HAP3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

13616:C1H16orf87
gene id: 13616:C1H16orf87
uniprot id: F7DY20
names: Similarity
messages: Belongs to the UPF0547 family.

13616:LOC100020912
gene id: 13616:LOC100020912
uniprot id: A0A5F8G1U1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:TMEM2
gene id: 13616:TMEM2
uniprot id: F7CEF4
names: Similarity
messages: Belongs to the CEMIP family.

13616:TMEM255A
gene id: 13616:TMEM255A
uniprot id: F6VLX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

13616:LOC100030425
gene id: 13616:LOC100030425
uniprot id: F7B4E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103102474
gene id: 13616:LOC103102474
uniprot id: A0A5F8GF55
names: Similarity
messages: Belongs to the CFAP97 family.

13616:MRPL12
gene id: 13616:MRPL12
uniprot id: F6PNJ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

13616:PAQR5
gene id: 13616:PAQR5
uniprot id: A0A5F8GD34
uniprot id: A0A5F8H5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:GPR18
gene id: 13616:GPR18
uniprot id: F7EB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

13616:FOXS1
gene id: 13616:FOXS1
uniprot id: F6WAA9
names: Subcellular Location Annotation
messages: Nucleus

13616:SNX6
gene id: 13616:SNX6
uniprot id: F7ERS0
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

13616:FUT8
gene id: 13616:FUT8
uniprot id: F6XAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

13616:LOC100033297
gene id: 13616:LOC100033297
uniprot id: F7FAG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:SRSF2
gene id: 13616:SRSF2
uniprot id: F7BX00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

13616:MKRN2
gene id: 13616:MKRN2
uniprot id: A0A5F8GSH8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:LOC100012131
gene id: 13616:LOC100012131
uniprot id: A0A5F8GGR0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:EEF1A1
gene id: 13616:EEF1A1
uniprot id: F6YDH0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

13616:BBS4
gene id: 13616:BBS4
uniprot id: A0A5F8HIT6
uniprot id: F6QM11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

13616:LAMB2
gene id: 13616:LAMB2
uniprot id: F6ZKA9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

13616:SLC8A3
gene id: 13616:SLC8A3
uniprot id: A0A5F8GZ84
uniprot id: A0A5F8H119
uniprot id: A0A5F8H3Q2
uniprot id: F7FC55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

13616:ZADH2
gene id: 13616:ZADH2
uniprot id: F7EIM5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

13616:GAB2
gene id: 13616:GAB2
uniprot id: A0A5F8GJS8
names: Similarity
messages: Belongs to the GAB family.

13616:HAGHL
gene id: 13616:HAGHL
uniprot id: A0A5F8GQ45
uniprot id: F7G5Y2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

13616:PNPLA1
gene id: 13616:PNPLA1
uniprot id: A0A5F8GKC3
uniprot id: F7AVV1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100019538
gene id: 13616:LOC100019538
uniprot id: A0A5F8GNZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

13616:KATNAL2
gene id: 13616:KATNAL2
uniprot id: A0A5F8G4S8
uniprot id: F6ZPW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

13616:ACVR2B
gene id: 13616:ACVR2B
uniprot id: A0A5F8GCP7
uniprot id: F7BRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

13616:UNC93A
gene id: 13616:UNC93A
uniprot id: F7F0N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

13616:KCNK9
gene id: 13616:KCNK9
uniprot id: F6SSW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

13616:TMEM150A
gene id: 13616:TMEM150A
uniprot id: F6YFN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

13616:monDomV1R1263
gene id: 13616:monDomV1R1263
uniprot id: A0A5F8GVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MAP3K7
gene id: 13616:MAP3K7
uniprot id: A0A5F8G5G8
uniprot id: A0A5F8GJ40
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

13616:PABPC4
gene id: 13616:PABPC4
uniprot id: F6YJX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

13616:LOC100025087
gene id: 13616:LOC100025087
uniprot id: F6SVK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PCYT2
gene id: 13616:PCYT2
uniprot id: A0A5F8H8T9
uniprot id: F6PLX5
names: Similarity
messages: Belongs to the cytidylyltransferase family.

13616:ZNF622
gene id: 13616:ZNF622
uniprot id: F7DCD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

13616:FAM96B
gene id: 13616:FAM96B
uniprot id: F7CX16
names: Similarity
messages: Belongs to the MIP18 family.

13616:LOC100032302
gene id: 13616:LOC100032302
uniprot id: F6VUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

13616:LOC100014635
gene id: 13616:LOC100014635
uniprot id: F6Y610
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MPG
gene id: 13616:MPG
uniprot id: F6YNB3
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

13616:HOXB7
gene id: 13616:HOXB7
uniprot id: A0A5F8H5Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:SLC35A3
gene id: 13616:SLC35A3
uniprot id: A0A5F8HK75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

13616:SEMA4C
gene id: 13616:SEMA4C
uniprot id: F6UE98
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RHOT1
gene id: 13616:RHOT1
uniprot id: F7FMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

13616:LOC100030127
gene id: 13616:LOC100030127
uniprot id: A0A5F8HKM4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

13616:ERBB2
gene id: 13616:ERBB2
uniprot id: A0A5F8GRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

13616:FAM213A
gene id: 13616:FAM213A
uniprot id: A0A5F8GWH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

13616:ADGRA3
gene id: 13616:ADGRA3
uniprot id: F6WP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

13616:CA14
gene id: 13616:CA14
uniprot id: A0A5F8GDW3
uniprot id: F7ADM5
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

13616:GTF2E1
gene id: 13616:GTF2E1
uniprot id: F6PGB5
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

13616:UPP2
gene id: 13616:UPP2
uniprot id: F6RS33
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

13616:RUNX1T1
gene id: 13616:RUNX1T1
uniprot id: A0A5F8GF88
uniprot id: A0A5F8GNU7
names: Similarity
messages: Belongs to the CBFA2T family.

13616:GNMT
gene id: 13616:GNMT
uniprot id: F7C5H5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

13616:EDEM1
gene id: 13616:EDEM1
uniprot id: F6R5E1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

13616:CD79B
gene id: 13616:CD79B
uniprot id: D7F469
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PARG
gene id: 13616:PARG
uniprot id: F7DIG7
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

13616:YME1L1
gene id: 13616:YME1L1
uniprot id: F7BVC8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

13616:ABCG5
gene id: 13616:ABCG5
uniprot id: F6X4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

13616:LOC103103968
gene id: 13616:LOC103103968
uniprot id: A0A5F8H357
names: Subcellular Location Annotation
messages: Nucleus

13616:ARSG
gene id: 13616:ARSG
uniprot id: A0A5F8GNI3
uniprot id: F6SVG1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:UBQLN1
gene id: 13616:UBQLN1
uniprot id: A0A5F8G4P0
uniprot id: F7CXM6
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

13616:NDUFB1
gene id: 13616:NDUFB1
uniprot id: A0A5F8GL68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:LOC100024824
gene id: 13616:LOC100024824
uniprot id: F7GII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SMC1B
gene id: 13616:SMC1B
uniprot id: F6VWT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

13616:LOC100025782
gene id: 13616:LOC100025782
uniprot id: F7CKQ0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:ACHE
gene id: 13616:ACHE
uniprot id: F7C2P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

13616:KEG11 p10
gene id: 13616:KEG11_p10
uniprot id: Q65CJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

13616:CLRN2
gene id: 13616:CLRN2
uniprot id: F7AVP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

13616:RNFT1
gene id: 13616:RNFT1
uniprot id: F6W4Q5
names: Subcellular Location Annotation
messages: Membrane

13616:KCTD3
gene id: 13616:KCTD3
uniprot id: F6ZPV3
names: Similarity
messages: Belongs to the KCTD3 family.

13616:FFAR2
gene id: 13616:FFAR2
uniprot id: F6W8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMEM17
gene id: 13616:TMEM17
uniprot id: F6PQE0
names: Subcellular Location Annotation
messages: Membrane

13616:PURA
gene id: 13616:PURA
uniprot id: F7FSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

13616:TMEM161A
gene id: 13616:TMEM161A
uniprot id: F6VW04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

13616:ITGB3
gene id: 13616:ITGB3
uniprot id: F7FW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

13616:LOC100011313
gene id: 13616:LOC100011313
uniprot id: F7DIB7
names: Similarity
messages: Belongs to the actin family.

13616:FAM124B
gene id: 13616:FAM124B
uniprot id: F6UH70
names: Similarity
messages: Belongs to the FAM124 family.

13616:PFKFB4
gene id: 13616:PFKFB4
uniprot id: A0A5F8G879
uniprot id: F6U5M3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

13616:SCUBE2
gene id: 13616:SCUBE2
uniprot id: A0A5F8HH90
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:GMNN
gene id: 13616:GMNN
uniprot id: F7GE78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

13616:monDomV1R1278
gene id: 13616:monDomV1R1278
uniprot id: A0A5F8HJM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HAO2
gene id: 13616:HAO2
uniprot id: F7GGG1
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

13616:CHST14
gene id: 13616:CHST14
uniprot id: A0A5F8H6E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LYAR
gene id: 13616:LYAR
uniprot id: F7F4L6
names: Subcellular Location Annotation
messages: Cytoplasm

13616:PSEN2
gene id: 13616:PSEN2
uniprot id: F7EIE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

13616:CCL20
gene id: 13616:CCL20
uniprot id: K7E0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:LOC100031866
gene id: 13616:LOC100031866
uniprot id: F6Y6H3
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

13616:LOC100021412
gene id: 13616:LOC100021412
uniprot id: A0A5F8GNR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CNDP2
gene id: 13616:CNDP2
uniprot id: F7DHK3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

13616:SNX2
gene id: 13616:SNX2
uniprot id: A0A5F8HGR3
uniprot id: F6WI51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

13616:SLC25A27
gene id: 13616:SLC25A27
uniprot id: A0A5F8GBV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100013197
gene id: 13616:LOC100013197
uniprot id: A0A5F8G4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:SLC15A4
gene id: 13616:SLC15A4
uniprot id: A0A5F8GK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

13616:MAP3K9
gene id: 13616:MAP3K9
uniprot id: A0A5F8G873
uniprot id: F6RYB4
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

13616:MARK3
gene id: 13616:MARK3
uniprot id: A0A5F8G689
uniprot id: A0A5F8GGQ5
uniprot id: A0A5F8HIE6
uniprot id: A0A5F8HJ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

13616:RPS3A
gene id: 13616:RPS3A
uniprot id: F7ESW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

13616:SPICE1
gene id: 13616:SPICE1
uniprot id: A0A5F8G7S9
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

13616:USP1
gene id: 13616:USP1
uniprot id: F7F488
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:SLC25A11
gene id: 13616:SLC25A11
uniprot id: F6YLG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:GATA4
gene id: 13616:GATA4
uniprot id: F7B924
names: Subcellular Location Annotation
messages: Nucleus

13616:SUGP1
gene id: 13616:SUGP1
uniprot id: F6UEG6
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC35D2
gene id: 13616:SLC35D2
uniprot id: F6U9P9
names: Subcellular Location Annotation
messages: Membrane

13616:LPCAT1
gene id: 13616:LPCAT1
uniprot id: F7BCV0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:NKD1
gene id: 13616:NKD1
uniprot id: A0A5F8HC55
uniprot id: F7FQ00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

13616:BOP1
gene id: 13616:BOP1
uniprot id: F7GHR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

13616:UBE3A
gene id: 13616:UBE3A
uniprot id: A0A5F8HFE2
uniprot id: F7A2Q4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

13616:TRIM36
gene id: 13616:TRIM36
uniprot id: F7DGH4
names: Subcellular Location Annotation
messages: cytoskeleton

13616:NT5C2
gene id: 13616:NT5C2
uniprot id: A0A5F8GVB7
uniprot id: F7ANM0
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

13616:LOC100019961
gene id: 13616:LOC100019961
uniprot id: A0A5F8GQP4
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

13616:INTS3
gene id: 13616:INTS3
uniprot id: F6VZW0
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

13616:GOLPH3
gene id: 13616:GOLPH3
uniprot id: A0A5F8G7D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

13616:IRF2BP1
gene id: 13616:IRF2BP1
uniprot id: F7E0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

13616:SMARCA2
gene id: 13616:SMARCA2
uniprot id: A0A5F8GLS8
uniprot id: F7FQB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

13616:LOC100020228
gene id: 13616:LOC100020228
uniprot id: F7F450
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

13616:TSPAN9
gene id: 13616:TSPAN9
uniprot id: F6PRY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:LOC100022942
gene id: 13616:LOC100022942
uniprot id: F7DG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IL2RB
gene id: 13616:IL2RB
uniprot id: F6SBB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

13616:AKT1
gene id: 13616:AKT1
uniprot id: F6QP11
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

13616:SDC3
gene id: 13616:SDC3
uniprot id: F6XHV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

13616:FAM189B
gene id: 13616:FAM189B
uniprot id: F7E0N9
names: Similarity
messages: Belongs to the ENTREP family.

13616:PIWIL4
gene id: 13616:PIWIL4
uniprot id: F6SZK3
names: Similarity
messages: Belongs to the argonaute family.

13616:FGF16
gene id: 13616:FGF16
uniprot id: F7D846
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:monDomV1R1244
gene id: 13616:monDomV1R1244
uniprot id: A0A5F8GCW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC35A5
gene id: 13616:SLC35A5
uniprot id: F7F201
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

13616:PELI2
gene id: 13616:PELI2
uniprot id: F7FZH7
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

13616:GLG1
gene id: 13616:GLG1
uniprot id: A0A5F8H2J2
uniprot id: F6YPR6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

13616:PIK3CG
gene id: 13616:PIK3CG
uniprot id: F7E9G2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

13616:TMPRSS5
gene id: 13616:TMPRSS5
uniprot id: A0A5F8G6F6
uniprot id: A0A5F8H3S0
uniprot id: F6TRE7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100029976
gene id: 13616:LOC100029976
uniprot id: A0A5F8G5P3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:LOC100028625
gene id: 13616:LOC100028625
uniprot id: F7G428
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

13616:CCS
gene id: 13616:CCS
uniprot id: F6YJP8
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

13616:CDK5R1
gene id: 13616:CDK5R1
uniprot id: F7F8X9
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

13616:MOCOS
gene id: 13616:MOCOS
uniprot id: A0A5F8GKW1
uniprot id: A0A5F8GXY5
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

13616:KPNA4
gene id: 13616:KPNA4
uniprot id: F7FL50
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:EMC7
gene id: 13616:EMC7
uniprot id: F6T7N4
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

13616:CCK
gene id: 13616:CCK
uniprot id: F7EMB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

13616:LOC100619918
gene id: 13616:LOC100619918
uniprot id: A0A5F8G8T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NUDT21
gene id: 13616:NUDT21
uniprot id: F7DTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

13616:PCSK2
gene id: 13616:PCSK2
uniprot id: F7G632
names: Similarity
messages: Belongs to the peptidase S8 family.

13616:MCM10
gene id: 13616:MCM10
uniprot id: F6QH58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

13616:HOXD13
gene id: 13616:HOXD13
uniprot id: F7BJZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:HDAC9
gene id: 13616:HDAC9
uniprot id: F7BC62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

13616:SNRPB
gene id: 13616:SNRPB
uniprot id: Q9TU66
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP SmB/SmN family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). Component of the U1 snRNP (By similarity). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (By similarity). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (By similarity). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (By similarity). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with TDRD3 and SNUPN (By similarity). Interacts with PRMT5; interaction lead…
messages: Methylated by PRMT5 (By similarity). Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
messages: cytosol

13616:PALM
gene id: 13616:PALM
uniprot id: F6ZR04
names: Similarity
messages: Belongs to the paralemmin family.

13616:TIMM17A
gene id: 13616:TIMM17A
uniprot id: F6Y5K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ADAM22
gene id: 13616:ADAM22
uniprot id: A0A5F8GL95
uniprot id: F6S926
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ZFP36
gene id: 13616:ZFP36
uniprot id: A0A5F8H080
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

13616:LOC100029137
gene id: 13616:LOC100029137
uniprot id: A0A5F8G6P6
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:MCTS1
gene id: 13616:MCTS1
uniprot id: F6RPB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

13616:PRICKLE1
gene id: 13616:PRICKLE1
uniprot id: F7CAA2
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

13616:LTBP2
gene id: 13616:LTBP2
uniprot id: F7FRW6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:LOC100024691
gene id: 13616:LOC100024691
uniprot id: F7D533
names: Similarity
messages: Belongs to the apolipoprotein L family.

13616:LOC100024395
gene id: 13616:LOC100024395
uniprot id: A0A5F8GJP2
names: Subcellular Location Annotation
messages: Membrane

13616:XK
gene id: 13616:XK
uniprot id: F6U2W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

13616:LOC100012829
gene id: 13616:LOC100012829
uniprot id: F6QLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100027914
gene id: 13616:LOC100027914
uniprot id: F6SWK4
names: Subcellular Location Annotation
messages: Nucleus

13616:TPST1
gene id: 13616:TPST1
uniprot id: A0A5F8G635
uniprot id: A0A5F8GXI1
uniprot id: F7CN44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

13616:DYNC2LI1
gene id: 13616:DYNC2LI1
uniprot id: F6XMM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

13616:FYN
gene id: 13616:FYN
uniprot id: F7FG65
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:CTU1
gene id: 13616:CTU1
uniprot id: F6RN02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

13616:URAD
gene id: 13616:URAD
uniprot id: A0A5F8G3T1
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

13616:SLC46A3
gene id: 13616:SLC46A3
uniprot id: F7B0M8
names: Subcellular Location Annotation
messages: Membrane

13616:GTF2H4
gene id: 13616:GTF2H4
uniprot id: F7F0D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

13616:CXHXorf56
gene id: 13616:CXHXorf56
uniprot id: A0A5F8GCG9
uniprot id: F6ST98
names: Similarity
messages: Belongs to the STEEP1 family.

13616:LOC100021052
gene id: 13616:LOC100021052
uniprot id: F6RPF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TLR2
gene id: 13616:TLR2
uniprot id: F6UTM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane
messages: Membrane raft
messages: phagosome membrane

13616:NR5A2
gene id: 13616:NR5A2
uniprot id: A0A5F8GP12
uniprot id: A0A5F8GP94
uniprot id: F7DCK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

13616:OSTC
gene id: 13616:OSTC
uniprot id: A0A5F8H7T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

13616:PHF10
gene id: 13616:PHF10
uniprot id: A0A5F8H364
uniprot id: F6UKY4
uniprot id: K7E191
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

13616:LOC100020659
gene id: 13616:LOC100020659
uniprot id: K7E0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

13616:KDM4C
gene id: 13616:KDM4C
uniprot id: F6V4I6
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

13616:APOM
gene id: 13616:APOM
uniprot id: A0A5F8HA42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

13616:NSUN2
gene id: 13616:NSUN2
uniprot id: F6QCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

13616:ABCC9
gene id: 13616:ABCC9
uniprot id: A0A5F8G687
uniprot id: A0A5F8GAT2
uniprot id: F6RD25
names: Subunit
messages: Interacts with KCNJ11.

13616:NT5DC3
gene id: 13616:NT5DC3
uniprot id: F7CVK9
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

13616:PLA1A
gene id: 13616:PLA1A
uniprot id: F7B6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

13616:SPCS3
gene id: 13616:SPCS3
uniprot id: A0A5F8GFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

13616:CCR6
gene id: 13616:CCR6
uniprot id: A0A5F8GLZ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TBCE
gene id: 13616:TBCE
uniprot id: A0A5F8GJR5
uniprot id: F7FGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

13616:FAM155B
gene id: 13616:FAM155B
uniprot id: A0A5F8G5Z4
uniprot id: F6UND5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

13616:SDF4
gene id: 13616:SDF4
uniprot id: F7A470
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

13616:CRABP2
gene id: 13616:CRABP2
uniprot id: F7FVK2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:POMGNT1
gene id: 13616:POMGNT1
uniprot id: F6UGR6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

13616:VN2R643
gene id: 13616:VN2R643
uniprot id: F7BFV4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:YAF2
gene id: 13616:YAF2
uniprot id: A0A5F8G5V8
uniprot id: A0A5F8HJ01
names: Subcellular Location Annotation
messages: Nucleus

13616:CHST13
gene id: 13616:CHST13
uniprot id: F7BKN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:HPGD
gene id: 13616:HPGD
uniprot id: A0A5F8G5J7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:EIF2B2
gene id: 13616:EIF2B2
uniprot id: F7FF88
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

13616:GRIN2C
gene id: 13616:GRIN2C
uniprot id: F6PSD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Membrane

13616:PSMA8
gene id: 13616:PSMA8
uniprot id: F7FSH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:RTN4IP1
gene id: 13616:RTN4IP1
uniprot id: F6Y476
uniprot id: K7E2Y8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

13616:EMG1
gene id: 13616:EMG1
uniprot id: A0A5F8GAG1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

13616:KCNAB3
gene id: 13616:KCNAB3
uniprot id: F7G0A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

13616:DBX1
gene id: 13616:DBX1
uniprot id: F7FQV1
names: Subcellular Location Annotation
messages: Nucleus

13616:OGT
gene id: 13616:OGT
uniprot id: F6Y3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

13616:IAPP
gene id: 13616:IAPP
uniprot id: A0A5F8H6U1
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

13616:COPS8
gene id: 13616:COPS8
uniprot id: F7CRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

13616:LOC103098551
gene id: 13616:LOC103098551
uniprot id: F7E6F9
names: Subcellular Location Annotation
messages: Membrane

13616:TAS1R1
gene id: 13616:TAS1R1
uniprot id: A0A5F8GIS7
uniprot id: F6SLE6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PLBD1
gene id: 13616:PLBD1
uniprot id: F7B6W0
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

13616:CPSF6
gene id: 13616:CPSF6
uniprot id: A0A5F8G6G5
uniprot id: A0A5F8H051
uniprot id: F6SH96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Cytoplasm
messages: Nucleus speckle
messages: nucleoplasm

13616:DOK5
gene id: 13616:DOK5
uniprot id: F7E8P9
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

13616:EPHA1
gene id: 13616:EPHA1
uniprot id: A0A5F8H3K2
uniprot id: F7APP4
names: Subcellular Location Annotation
messages: Membrane

13616:ANKLE2
gene id: 13616:ANKLE2
uniprot id: F7BA30
names: Similarity
messages: Belongs to the ANKLE2 family.

13616:STC1
gene id: 13616:STC1
uniprot id: F7G6I0
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

13616:KCNJ10
gene id: 13616:KCNJ10
uniprot id: F6PGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

13616:FAM219B
gene id: 13616:FAM219B
uniprot id: A0A5F8GX09
names: Similarity
messages: Belongs to the FAM219 family.

13616:LOC100023635
gene id: 13616:LOC100023635
uniprot id: F7DDZ3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

13616:LOC103098388
gene id: 13616:LOC103098388
uniprot id: K7E508
names: Subcellular Location Annotation
messages: Membrane raft
messages: phagosome membrane

13616:SPRN
gene id: 13616:SPRN
uniprot id: A2BDG4
names: Function
names: Similarity
messages: Belongs to the SPRN family.
messages: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.

13616:GSX1
gene id: 13616:GSX1
uniprot id: F7BPX3
names: Subcellular Location Annotation
messages: Nucleus

13616:AZGP1
gene id: 13616:AZGP1
uniprot id: F6PMH2
names: Similarity
messages: Belongs to the MHC class I family.

13616:SEMA3B
gene id: 13616:SEMA3B
uniprot id: F7CEG7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ICT1
gene id: 13616:ICT1
uniprot id: A0A5F8H4P4
names: Subcellular Location Annotation
messages: Mitochondrion

13616:SLC11A1
gene id: 13616:SLC11A1
uniprot id: F6WFG3
names: Similarity
messages: Belongs to the NRAMP family.

13616:NFU1
gene id: 13616:NFU1
uniprot id: F7CBJ3
names: Similarity
messages: Belongs to the NifU family.

13616:MB21D2
gene id: 13616:MB21D2
uniprot id: F7ELX9
names: Similarity
messages: Belongs to the mab-21 family.

13616:LOC100011174
gene id: 13616:LOC100011174
uniprot id: F6T501
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

13616:CD28
gene id: 13616:CD28
uniprot id: F7AY22
names: Subcellular Location Annotation
messages: Membrane

13616:DFNA5
gene id: 13616:DFNA5
uniprot id: F6W5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

13616:IRX1
gene id: 13616:IRX1
uniprot id: F7BBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:KCNJ11
gene id: 13616:KCNJ11
uniprot id: F6XUJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

13616:ADGRG5
gene id: 13616:ADGRG5
uniprot id: A0A5F8HLE8
names: Subcellular Location Annotation
messages: Membrane

13616:FIGF
gene id: 13616:FIGF
uniprot id: F6WHL4
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:SMARCAL1
gene id: 13616:SMARCAL1
uniprot id: F6SKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

13616:LOC100031900
gene id: 13616:LOC100031900
uniprot id: F6XJ86
names: Similarity
messages: Belongs to the lst-2 family.

13616:TMEM59L
gene id: 13616:TMEM59L
uniprot id: F7GBI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:SLC25A25
gene id: 13616:SLC25A25
uniprot id: A0A5F8G207
uniprot id: A0A5F8GBG4
uniprot id: A0A5F8GQJ4
uniprot id: F6QEH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:TBX20
gene id: 13616:TBX20
uniprot id: F6Q953
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:MED26
gene id: 13616:MED26
uniprot id: A0A5F8HCF8
uniprot id: A0A5F8HCS2
uniprot id: A0A5F8HIV1
uniprot id: F7FID8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

13616:RPL23
gene id: 13616:RPL23
uniprot id: F6WU43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

13616:ENOPH1
gene id: 13616:ENOPH1
uniprot id: F7DZJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

13616:LOC107649407
gene id: 13616:LOC107649407
uniprot id: F7DRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CAND2
gene id: 13616:CAND2
uniprot id: F7G2I7
names: Similarity
messages: Belongs to the CAND family.

13616:PDC
gene id: 13616:PDC
uniprot id: F6YE86
names: Similarity
messages: Belongs to the phosducin family.

13616:LOC100022788
gene id: 13616:LOC100022788
uniprot id: F7CMZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:AXIN2
gene id: 13616:AXIN2
uniprot id: F6TVK6
names: Subcellular Location Annotation
messages: Cytoplasm

13616:RNASE4
gene id: 13616:RNASE4
uniprot id: F6QVB3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:SSTR2
gene id: 13616:SSTR2
uniprot id: F7F878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

13616:PLPPR3
gene id: 13616:PLPPR3
uniprot id: F7FE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:SULT6B1
gene id: 13616:SULT6B1
uniprot id: F6TLW8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:PHKG2
gene id: 13616:PHKG2
uniprot id: F7ANI3
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

13616:PSME3
gene id: 13616:PSME3
uniprot id: A0A5F8H5U2
names: Similarity
messages: Belongs to the PA28 family.

13616:GNG8
gene id: 13616:GNG8
uniprot id: F6YZA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:PSMB11
gene id: 13616:PSMB11
uniprot id: F7CZ29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:TCP11L1
gene id: 13616:TCP11L1
uniprot id: F6XSJ5
names: Similarity
messages: Belongs to the TCP11 family.

13616:UCHL1
gene id: 13616:UCHL1
uniprot id: P50103
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.
messages: Monomer. Homodimer. Interacts with COPS5 and SNCA (By similarity).
messages: O-glycosylated.
messages: The homodimer may have ATP-independent ubiquitin ligase activity. However, in another study, UCHL1 was shown to lack ubiquitin ligase activity.
messages: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).

13616:CDH3
gene id: 13616:CDH3
uniprot id: F7EGB5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:NOC3L
gene id: 13616:NOC3L
uniprot id: F6VL05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

13616:RAB27A
gene id: 13616:RAB27A
uniprot id: F7D6A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

13616:ZACN
gene id: 13616:ZACN
uniprot id: F6ZYC6
names: Subcellular Location Annotation
messages: Membrane

13616:SELE
gene id: 13616:SELE
uniprot id: A0A5F8HET5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:SYT2
gene id: 13616:SYT2
uniprot id: F6WM83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

13616:STAG3
gene id: 13616:STAG3
uniprot id: F6RTQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

13616:CILP
gene id: 13616:CILP
uniprot id: F6SSK8
names: Subcellular Location Annotation
messages: extracellular matrix

13616:SEC16A
gene id: 13616:SEC16A
uniprot id: F7B5A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

13616:TNKS
gene id: 13616:TNKS
uniprot id: A0A5F8GUB1
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:ALLC
gene id: 13616:ALLC
uniprot id: A0A5F8H3S7
uniprot id: F7ERQ3
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

13616:THTPA
gene id: 13616:THTPA
uniprot id: A0A5F8GA32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

13616:DEDD
gene id: 13616:DEDD
uniprot id: A0A5F8GXA3
uniprot id: A0A5F8GYM0
names: Subcellular Location Annotation
messages: nucleolus

13616:LOC100026824
gene id: 13616:LOC100026824
uniprot id: A0A5F8HDW6
uniprot id: F6QBU5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:GJD3
gene id: 13616:GJD3
uniprot id: F7BMQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:WNT9A
gene id: 13616:WNT9A
uniprot id: F6SF10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:KCNK5
gene id: 13616:KCNK5
uniprot id: F6ZM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:DHRS7
gene id: 13616:DHRS7
uniprot id: F7CCB2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:ARMC8
gene id: 13616:ARMC8
uniprot id: A0A5F8H532
uniprot id: A0A5F8HHK5
uniprot id: F7G243
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:LOC100031116
gene id: 13616:LOC100031116
uniprot id: A0A5F8GGW3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:AFF2
gene id: 13616:AFF2
uniprot id: A0A5F8H9R2
uniprot id: F7F3C1
names: Similarity
messages: Belongs to the AF4 family.

13616:ARID5B
gene id: 13616:ARID5B
uniprot id: F6V2Y7
names: Similarity
messages: Belongs to the ARID5B family.

13616:NATD1
gene id: 13616:NATD1
uniprot id: A0A5F8HII4
uniprot id: F7BD69
names: Similarity
messages: Belongs to the NATD1 family.

13616:SPAG9
gene id: 13616:SPAG9
uniprot id: A0A5F8HE29
names: Similarity
messages: Belongs to the JIP scaffold family.

13616:TRAK1
gene id: 13616:TRAK1
uniprot id: A0A5F8HAG5
uniprot id: A0A5F8HIC1
uniprot id: A0A5F8HJA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

13616:MCCC2
gene id: 13616:MCCC2
uniprot id: F6T882
names: Similarity
messages: Belongs to the AccD/PCCB family.

13616:EDN2
gene id: 13616:EDN2
uniprot id: K7E5U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

13616:SGSH
gene id: 13616:SGSH
uniprot id: F7DFZ7
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:MDM2
gene id: 13616:MDM2
uniprot id: F6WSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

13616:PRPF4
gene id: 13616:PRPF4
uniprot id: F6RSY7
names: Subcellular Location Annotation
messages: Nucleus speckle

13616:STAG2
gene id: 13616:STAG2
uniprot id: F6ZBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

13616:LOC100032863
gene id: 13616:LOC100032863
uniprot id: F6TG00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

13616:RBM17
gene id: 13616:RBM17
uniprot id: F7GGT5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

13616:CYSLTR2
gene id: 13616:CYSLTR2
uniprot id: F6XJU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:GABRA2
gene id: 13616:GABRA2
uniprot id: F6ZBY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

13616:CSRNP3
gene id: 13616:CSRNP3
uniprot id: A0A5F8G8G9
uniprot id: A0A5F8GW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

13616:LYRM4
gene id: 13616:LYRM4
uniprot id: A0A5F8GXK9
uniprot id: A0A5F8H234
uniprot id: A0A5F8H7Y2
names: Similarity
messages: Belongs to the complex I LYR family.