1318466:BN854 RS05860
gene id: 1318466:BN854_RS05860
uniprot id: U4KS54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

1318466:BN854 RS05960
gene id: 1318466:BN854_RS05960
uniprot id: U4KS62
names: Similarity
messages: Belongs to the pyruvate kinase family.

1318466:BN854 RS00600
gene id: 1318466:BN854_RS00600
uniprot id: U4KJK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS00765
gene id: 1318466:BN854_RS00765
uniprot id: U4KNG3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1318466:BN854 RS02650
gene id: 1318466:BN854_RS02650
uniprot id: U4KKG5
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1318466:BN854 RS02580
gene id: 1318466:BN854_RS02580
uniprot id: U4KKH8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1318466:BN854 RS06670
gene id: 1318466:BN854_RS06670
uniprot id: U4KSC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1318466:BN854 RS06285
gene id: 1318466:BN854_RS06285
uniprot id: U4KLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1318466:BN854 RS06445
gene id: 1318466:BN854_RS06445
uniprot id: U4KQM8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1318466:BN854 RS04340
gene id: 1318466:BN854_RS04340
uniprot id: U4KL20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

1318466:BN854 RS06965
gene id: 1318466:BN854_RS06965
uniprot id: U4KLY6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

1318466:BN854 RS02205
gene id: 1318466:BN854_RS02205
uniprot id: U4KRB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

1318466:BN854 RS00705
gene id: 1318466:BN854_RS00705
uniprot id: U4KNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1318466:BN854 RS07035
gene id: 1318466:BN854_RS07035
uniprot id: U4KLW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1318466:BN854 RS03715
gene id: 1318466:BN854_RS03715
uniprot id: U4KRN1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1318466:BN854 RS07245
gene id: 1318466:BN854_RS07245
uniprot id: U4KM18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS06300
gene id: 1318466:BN854_RS06300
uniprot id: U4KS88
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1318466:BN854 RS03305
gene id: 1318466:BN854_RS03305
uniprot id: U4KKP4
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

1318466:BN854 RS01425
gene id: 1318466:BN854_RS01425
uniprot id: U4KK24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1318466:BN854 RS04985
gene id: 1318466:BN854_RS04985
uniprot id: U4KRY8
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

1318466:BN854 RS02655
gene id: 1318466:BN854_RS02655
uniprot id: U4KKX8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS04495
gene id: 1318466:BN854_RS04495
uniprot id: U4KL52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1318466:BN854 RS02550
gene id: 1318466:BN854_RS02550
uniprot id: U4KKF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1318466:BN854 RS05180
gene id: 1318466:BN854_RS05180
uniprot id: U4KQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1318466:BN854 RS04960
gene id: 1318466:BN854_RS04960
uniprot id: U4KRY6
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

1318466:BN854 RS04610
gene id: 1318466:BN854_RS04610
uniprot id: U4KRV9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS03240
gene id: 1318466:BN854_RS03240
uniprot id: U4KKG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS01240
gene id: 1318466:BN854_RS01240
uniprot id: U4KR30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

1318466:BN854 RS05175
gene id: 1318466:BN854_RS05175
uniprot id: U4KL44
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1318466:BN854 RS05840
gene id: 1318466:BN854_RS05840
uniprot id: U4KLJ7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

1318466:BN854 RS03665
gene id: 1318466:BN854_RS03665
uniprot id: U4KRM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1318466:BN854 RS02450
gene id: 1318466:BN854_RS02450
uniprot id: U4KKE0
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

1318466:BN854 RS03885
gene id: 1318466:BN854_RS03885
uniprot id: U4KRP1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1318466:BN854 RS04595
gene id: 1318466:BN854_RS04595
uniprot id: U4KKX8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS02475
gene id: 1318466:BN854_RS02475
uniprot id: U4KKE3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS00635
gene id: 1318466:BN854_RS00635
uniprot id: U4KQY1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1318466:BN854 RS04670
gene id: 1318466:BN854_RS04670
uniprot id: U4KL72
names: Similarity
messages: Belongs to the antibiotic N-acetyltransferase family.

1318466:BN854 RS05160
gene id: 1318466:BN854_RS05160
uniprot id: U4KS02
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS01180
gene id: 1318466:BN854_RS01180
uniprot id: U4KJS3
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1318466:BN854 RS03930
gene id: 1318466:BN854_RS03930
uniprot id: U4KPX3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1318466:BN854 RS07510
gene id: 1318466:BN854_RS07510
uniprot id: U4KQP5
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS05475
gene id: 1318466:BN854_RS05475
uniprot id: U4KQJ4
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS05490
gene id: 1318466:BN854_RS05490
uniprot id: U4KQI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS06500
gene id: 1318466:BN854_RS06500
uniprot id: U4KLR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1318466:BN854 RS03290
gene id: 1318466:BN854_RS03290
uniprot id: U4KKG6
names: Similarity
messages: Belongs to the FGGY kinase family.

1318466:BN854 RS05440
gene id: 1318466:BN854_RS05440
uniprot id: U4KS22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1318466:BN854 RS02615
gene id: 1318466:BN854_RS02615
uniprot id: U4KPD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS04310
gene id: 1318466:BN854_RS04310
uniprot id: U4KQ72
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1318466:BN854 RS05965
gene id: 1318466:BN854_RS05965
uniprot id: U4KLL1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS02440
gene id: 1318466:BN854_RS02440
uniprot id: U4KPA8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1318466:BN854 RS04620
gene id: 1318466:BN854_RS04620
uniprot id: U4KL66
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1318466:BN854 RS06580
gene id: 1318466:BN854_RS06580
uniprot id: U4KLT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1318466:BN854 RS00130
gene id: 1318466:BN854_RS00130
uniprot id: U4KJM0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1318466:BN854 RS01345
gene id: 1318466:BN854_RS01345
uniprot id: U4KK08
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1318466:BN854 RS04320
gene id: 1318466:BN854_RS04320
uniprot id: U4KL32
names: Similarity
messages: Belongs to the BMP lipoprotein family.

1318466:BN854 RS05305
gene id: 1318466:BN854_RS05305
uniprot id: U4KQI2
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS06625
gene id: 1318466:BN854_RS06625
uniprot id: U4KLT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

1318466:BN854 RS01590
gene id: 1318466:BN854_RS01590
uniprot id: U4KNU7
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1318466:BN854 RS06695
gene id: 1318466:BN854_RS06695
uniprot id: U4KSC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1318466:BN854 RS03490
gene id: 1318466:BN854_RS03490
uniprot id: U4KRL2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS03670
gene id: 1318466:BN854_RS03670
uniprot id: U4KKT7
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1318466:BN854 RS01840
gene id: 1318466:BN854_RS01840
uniprot id: U4KR84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS06920
gene id: 1318466:BN854_RS06920
uniprot id: U4KLS7
names: Similarity
messages: Belongs to the ParB family.

1318466:BN854 RS07210
gene id: 1318466:BN854_RS07210
uniprot id: U4KSG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1318466:BN854 RS07910
gene id: 1318466:BN854_RS07910
uniprot id: U4KSE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1318466:BN854 RS02555
gene id: 1318466:BN854_RS02555
uniprot id: U4KKH5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS06340
gene id: 1318466:BN854_RS06340
uniprot id: U4KLK0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1318466:BN854 RS04460
gene id: 1318466:BN854_RS04460
uniprot id: U4KRU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS07515
gene id: 1318466:BN854_RS07515
uniprot id: U4KLY4
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS01885
gene id: 1318466:BN854_RS01885
uniprot id: U4KP21
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS06265
gene id: 1318466:BN854_RS06265
uniprot id: U4KLI9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1318466:BN854 RS00235
gene id: 1318466:BN854_RS00235
uniprot id: U4KJP2
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS01550
gene id: 1318466:BN854_RS01550
uniprot id: U4KQJ4
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS06645
gene id: 1318466:BN854_RS06645
uniprot id: U4KSB7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1318466:BN854 RS00165
gene id: 1318466:BN854_RS00165
uniprot id: U4KJJ2
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

1318466:BN854 RS07150
gene id: 1318466:BN854_RS07150
uniprot id: U4KQQ3
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1318466:BN854 RS05830
gene id: 1318466:BN854_RS05830
uniprot id: U4KQK3
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

1318466:BN854 RS05410
gene id: 1318466:BN854_RS05410
uniprot id: U4KQI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1318466:BN854 RS06330
gene id: 1318466:BN854_RS06330
uniprot id: U4KLQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1318466:BN854 RS06390
gene id: 1318466:BN854_RS06390
uniprot id: U4KLK6
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS07055
gene id: 1318466:BN854_RS07055
uniprot id: U4KSF4
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1318466:BN854 RS07240
gene id: 1318466:BN854_RS07240
uniprot id: U4KLZ2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1318466:BN854 RS05400
gene id: 1318466:BN854_RS05400
uniprot id: U4KLF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1318466:BN854 RS06220
gene id: 1318466:BN854_RS06220
uniprot id: U4KQL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1318466:BN854 RS02670
gene id: 1318466:BN854_RS02670
uniprot id: U4KRE8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1318466:BN854 RS02420
gene id: 1318466:BN854_RS02420
uniprot id: U4KRC9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1318466:BN854 RS01415
gene id: 1318466:BN854_RS01415
uniprot id: U4KR43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1318466:BN854 RS06145
gene id: 1318466:BN854_RS06145
uniprot id: U4KLH3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS04665
gene id: 1318466:BN854_RS04665
uniprot id: U4KL56
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1318466:BN854 RS00050
gene id: 1318466:BN854_RS00050
uniprot id: U4KKX8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS05540
gene id: 1318466:BN854_RS05540
uniprot id: U4KQJ1
names: Similarity
messages: Belongs to the fabD family.

1318466:BN854 RS04520
gene id: 1318466:BN854_RS04520
uniprot id: U4KL55
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

1318466:BN854 RS02115
gene id: 1318466:BN854_RS02115
uniprot id: U4KP57
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS05585
gene id: 1318466:BN854_RS05585
uniprot id: U4KL98
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS01900
gene id: 1318466:BN854_RS01900
uniprot id: U4KKA3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS06060
gene id: 1318466:BN854_RS06060
uniprot id: U4KLM3
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1318466:BN854 RS06195
gene id: 1318466:BN854_RS06195
uniprot id: U4KLH9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1318466:BN854 RS02945
gene id: 1318466:BN854_RS02945
uniprot id: U4KKK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1318466:BN854 RS06225
gene id: 1318466:BN854_RS06225
uniprot id: U4KS84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1318466:BN854 RS05950
gene id: 1318466:BN854_RS05950
uniprot id: U4KLE7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS07500
gene id: 1318466:BN854_RS07500
uniprot id: U4KSB4
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS03505
gene id: 1318466:BN854_RS03505
uniprot id: U4KKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1318466:BN854 RS02405
gene id: 1318466:BN854_RS02405
uniprot id: U4KKF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

1318466:BN854 RS03910
gene id: 1318466:BN854_RS03910
uniprot id: U4KRP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1318466:BN854 RS02370
gene id: 1318466:BN854_RS02370
uniprot id: U4KRC5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1318466:BN854 RS07000
gene id: 1318466:BN854_RS07000
uniprot id: U4KQP7
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS05090
gene id: 1318466:BN854_RS05090
uniprot id: U4KLA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1318466:BN854 RS03235
gene id: 1318466:BN854_RS03235
uniprot id: U4KKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS00700
gene id: 1318466:BN854_RS00700
uniprot id: U4KJL6
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1318466:BN854 RS00155
gene id: 1318466:BN854_RS00155
uniprot id: U4KJM3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1318466:BN854 RS06085
gene id: 1318466:BN854_RS06085
uniprot id: U4KLM6
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02065
gene id: 1318466:BN854_RS02065
uniprot id: U4KRA1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1318466:BN854 RS07020
gene id: 1318466:BN854_RS07020
uniprot id: U4KLT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1318466:BN854 RS01365
gene id: 1318466:BN854_RS01365
uniprot id: U4KR39
names: Similarity
messages: Belongs to the ArsC family.

1318466:BN854 RS01620
gene id: 1318466:BN854_RS01620
uniprot id: U4KNV2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1318466:BN854 RS07025
gene id: 1318466:BN854_RS07025
uniprot id: U4KQP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS05385
gene id: 1318466:BN854_RS05385
uniprot id: U4KS19
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS03985
gene id: 1318466:BN854_RS03985
uniprot id: U4KRQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

1318466:BN854 RS04755
gene id: 1318466:BN854_RS04755
uniprot id: U4KQD3
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS06490
gene id: 1318466:BN854_RS06490
uniprot id: U4KQN0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1318466:BN854 RS00795
gene id: 1318466:BN854_RS00795
uniprot id: U4KQZ5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1318466:BN854 RS00510
gene id: 1318466:BN854_RS00510
uniprot id: U4KNC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1318466:BN854 RS05570
gene id: 1318466:BN854_RS05570
uniprot id: U4KS32
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1318466:BN854 RS07310
gene id: 1318466:BN854_RS07310
uniprot id: U4KSH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS04585
gene id: 1318466:BN854_RS04585
uniprot id: U4KRV7
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1318466:BN854 RS00875
gene id: 1318466:BN854_RS00875
uniprot id: U4KJW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1318466:BN854 RS01510
gene id: 1318466:BN854_RS01510
uniprot id: U4KK26
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Binds crRNA and tracrRNA.

1318466:BN854 RS07060
gene id: 1318466:BN854_RS07060
uniprot id: U4KLX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1318466:BN854 RS04050
gene id: 1318466:BN854_RS04050
uniprot id: U4KKR2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS02075
gene id: 1318466:BN854_RS02075
uniprot id: U4KKC2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1318466:BN854 RS03205
gene id: 1318466:BN854_RS03205
uniprot id: U4KKN2
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1318466:BN854 RS06515
gene id: 1318466:BN854_RS06515
uniprot id: U4KQN1
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1318466:BN854 RS01140
gene id: 1318466:BN854_RS01140
uniprot id: U4KR22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS04630
gene id: 1318466:BN854_RS04630
uniprot id: U4KQB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1318466:BN854 RS04905
gene id: 1318466:BN854_RS04905
uniprot id: U4KQF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1318466:BN854 RS02875
gene id: 1318466:BN854_RS02875
uniprot id: U4KKL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS02600
gene id: 1318466:BN854_RS02600
uniprot id: U4KKF9
names: Similarity
messages: Belongs to the UxaA family.

1318466:BN854 RS01435
gene id: 1318466:BN854_RS01435
uniprot id: U4KNR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1318466:BN854 RS05315
gene id: 1318466:BN854_RS05315
uniprot id: U4KLD5
names: Subcellular Location Annotation
messages: Cytoplasm

1318466:BN854 RS05580
gene id: 1318466:BN854_RS05580
uniprot id: U4KLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1318466:BN854 RS01325
gene id: 1318466:BN854_RS01325
uniprot id: U4KK09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS05255
gene id: 1318466:BN854_RS05255
uniprot id: U4KQI0
names: Similarity
messages: Belongs to the DEAD box helicase family.

1318466:BN854 RS06805
gene id: 1318466:BN854_RS06805
uniprot id: U4KLX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1318466:BN854 RS00520
gene id: 1318466:BN854_RS00520
uniprot id: U4KJR6
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

1318466:BN854 RS03085
gene id: 1318466:BN854_RS03085
uniprot id: U4KPK4
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02685
gene id: 1318466:BN854_RS02685
uniprot id: U4KK88
names: Similarity
messages: Belongs to the glutamine synthetase family.

1318466:BN854 RS00495
gene id: 1318466:BN854_RS00495
uniprot id: U4KJR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1318466:BN854 RS02520
gene id: 1318466:BN854_RS02520
uniprot id: U4KRD6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1318466:BN854 RS05185
gene id: 1318466:BN854_RS05185
uniprot id: U4KS03
names: Similarity
messages: Belongs to the peptidase S66 family.

1318466:BN854 RS00040
gene id: 1318466:BN854_RS00040
uniprot id: U4KJI7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1318466:BN854 RS05535
gene id: 1318466:BN854_RS05535
uniprot id: U4KL91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1318466:BN854 RS07030
gene id: 1318466:BN854_RS07030
uniprot id: U4KSF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1318466:BN854 RS03710
gene id: 1318466:BN854_RS03710
uniprot id: U4KPU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1318466:BN854 RS05810
gene id: 1318466:BN854_RS05810
uniprot id: U4KS50
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS03345
gene id: 1318466:BN854_RS03345
uniprot id: U4KPN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1318466:BN854 RS03275
gene id: 1318466:BN854_RS03275
uniprot id: U4KRJ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1318466:BN854 RS03165
gene id: 1318466:BN854_RS03165
uniprot id: U4KKF1
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1318466:BN854 RS06315
gene id: 1318466:BN854_RS06315
uniprot id: U4KLJ6
names: Similarity
messages: Belongs to the Dps family.

1318466:BN854 RS04880
gene id: 1318466:BN854_RS04880
uniprot id: U4KQE7
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1318466:BN854 RS06335
gene id: 1318466:BN854_RS06335
uniprot id: U4KLQ5
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1318466:BN854 RS03195
gene id: 1318466:BN854_RS03195
uniprot id: U4KPL9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

1318466:BN854 RS06450
gene id: 1318466:BN854_RS06450
uniprot id: U4KS97
names: Similarity
messages: Belongs to the peptidase C59 family.

1318466:BN854 RS07200
gene id: 1318466:BN854_RS07200
uniprot id: U4KLV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1318466:BN854 RS05420
gene id: 1318466:BN854_RS05420
uniprot id: U4KLE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1318466:BN854 RS03535
gene id: 1318466:BN854_RS03535
uniprot id: U4KPR5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1318466:BN854 RS04715
gene id: 1318466:BN854_RS04715
uniprot id: U4KL62
names: Caution
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS03215
gene id: 1318466:BN854_RS03215
uniprot id: U4KKF7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1318466:BN854 RS05425
gene id: 1318466:BN854_RS05425
uniprot id: U4KLF4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1318466:BN854 RS05590
gene id: 1318466:BN854_RS05590
uniprot id: U4KQJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1318466:BN854 RS01835
gene id: 1318466:BN854_RS01835
uniprot id: U4KP13
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1318466:BN854 RS02810
gene id: 1318466:BN854_RS02810
uniprot id: U4KPG3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1318466:BN854 RS02970
gene id: 1318466:BN854_RS02970
uniprot id: U4KKK4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1318466:BN854 RS02820
gene id: 1318466:BN854_RS02820
uniprot id: U4KKI6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS06025
gene id: 1318466:BN854_RS06025
uniprot id: U4KQL1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS04415
gene id: 1318466:BN854_RS04415
uniprot id: U4KL28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1318466:BN854 RS01245
gene id: 1318466:BN854_RS01245
uniprot id: U4KJZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1318466:BN854 RS03355
gene id: 1318466:BN854_RS03355
uniprot id: U4KKP9
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02800
gene id: 1318466:BN854_RS02800
uniprot id: U4KKK3
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

1318466:BN854 RS05530
gene id: 1318466:BN854_RS05530
uniprot id: U4KLG5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1318466:BN854 RS06435
gene id: 1318466:BN854_RS06435
uniprot id: U4KLR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1318466:BN854 RS01890
gene id: 1318466:BN854_RS01890
uniprot id: U4KR88
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS00860
gene id: 1318466:BN854_RS00860
uniprot id: U4KNI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1318466:BN854 RS05550
gene id: 1318466:BN854_RS05550
uniprot id: U4KLG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1318466:BN854 RS04885
gene id: 1318466:BN854_RS04885
uniprot id: U4KRY0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1318466:BN854 RS00345
gene id: 1318466:BN854_RS00345
uniprot id: U4KJP8
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

1318466:BN854 RS04675
gene id: 1318466:BN854_RS04675
uniprot id: U4KKZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1318466:BN854 RS03335
gene id: 1318466:BN854_RS03335
uniprot id: U4KKR3
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS06940
gene id: 1318466:BN854_RS06940
uniprot id: U4KLY3
names: Similarity
messages: Belongs to the transketolase family.

1318466:BN854 RS06725
gene id: 1318466:BN854_RS06725
uniprot id: U4KLV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1318466:BN854 RS07040
gene id: 1318466:BN854_RS07040
uniprot id: U4KLZ6
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1318466:BN854 RS00685
gene id: 1318466:BN854_RS00685
uniprot id: U4KQY6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

1318466:BN854 RS03020
gene id: 1318466:BN854_RS03020
uniprot id: U4KRH5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1318466:BN854 RS00325
gene id: 1318466:BN854_RS00325
uniprot id: U4KJQ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS05110
gene id: 1318466:BN854_RS05110
uniprot id: U4KRZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1318466:BN854 RS01190
gene id: 1318466:BN854_RS01190
uniprot id: U4KR26
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1318466:BN854 RS01715
gene id: 1318466:BN854_RS01715
uniprot id: U4KNY0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1318466:BN854 RS05370
gene id: 1318466:BN854_RS05370
uniprot id: U4KLE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

1318466:BN854 RS07340
gene id: 1318466:BN854_RS07340
uniprot id: U4KM04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1318466:BN854 RS00905
gene id: 1318466:BN854_RS00905
uniprot id: U4KJP3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1318466:BN854 RS06960
gene id: 1318466:BN854_RS06960
uniprot id: U4KLW3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS04890
gene id: 1318466:BN854_RS04890
uniprot id: U4KL83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS04685
gene id: 1318466:BN854_RS04685
uniprot id: U4KRW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1318466:BN854 RS04385
gene id: 1318466:BN854_RS04385
uniprot id: U4KRU2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS05310
gene id: 1318466:BN854_RS05310
uniprot id: U4KS13
names: Similarity
messages: Belongs to the peptidase M13 family.

1318466:BN854 RS03470
gene id: 1318466:BN854_RS03470
uniprot id: U4KRL0
names: Similarity
messages: Belongs to the SHMT family.

1318466:BN854 RS01695
gene id: 1318466:BN854_RS01695
uniprot id: U4KR63
names: Similarity
messages: Belongs to the LOG family.

1318466:BN854 RS06610
gene id: 1318466:BN854_RS06610
uniprot id: U4KLN6
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1318466:BN854 RS03915
gene id: 1318466:BN854_RS03915
uniprot id: U4KKW2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1318466:BN854 RS02510
gene id: 1318466:BN854_RS02510
uniprot id: U4KK69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1318466:BN854 RS00090
gene id: 1318466:BN854_RS00090
uniprot id: U4KJI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1318466:BN854 RS01215
gene id: 1318466:BN854_RS01215
uniprot id: U4KR28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1318466:BN854 RS02330
gene id: 1318466:BN854_RS02330
uniprot id: U4KKF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1318466:BN854 RS03640
gene id: 1318466:BN854_RS03640
uniprot id: U4KRM4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1318466:BN854 RS05575
gene id: 1318466:BN854_RS05575
uniprot id: U4KLG4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1318466:BN854 RS07095
gene id: 1318466:BN854_RS07095
uniprot id: U4KLU5
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1318466:BN854 RS04590
gene id: 1318466:BN854_RS04590
uniprot id: U4KL49
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS04485
gene id: 1318466:BN854_RS04485
uniprot id: U4KRV0
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

1318466:BN854 RS07545
gene id: 1318466:BN854_RS07545
uniprot id: U4KRB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1318466:BN854 RS05165
gene id: 1318466:BN854_RS05165
uniprot id: U4KLB6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS05390
gene id: 1318466:BN854_RS05390
uniprot id: U4KLE4
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS03120
gene id: 1318466:BN854_RS03120
uniprot id: U4KKM2
names: Similarity
messages: Belongs to the peptidase C1 family.

1318466:BN854 RS02210
gene id: 1318466:BN854_RS02210
uniprot id: U4KKB2
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

1318466:BN854 RS06420
gene id: 1318466:BN854_RS06420
uniprot id: U4KQM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1318466:BN854 RS01355
gene id: 1318466:BN854_RS01355
uniprot id: U4KJU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS05945
gene id: 1318466:BN854_RS05945
uniprot id: U4KLL3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS05435
gene id: 1318466:BN854_RS05435
uniprot id: U4KQI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1318466:BN854 RS01780
gene id: 1318466:BN854_RS01780
uniprot id: U4KK87
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1318466:BN854 RS04390
gene id: 1318466:BN854_RS04390
uniprot id: U4KL25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS01385
gene id: 1318466:BN854_RS01385
uniprot id: U4KNR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1318466:BN854 RS01910
gene id: 1318466:BN854_RS01910
uniprot id: U4KP25
names: Similarity
messages: Belongs to the peptidase M29 family.

1318466:BN854 RS05135
gene id: 1318466:BN854_RS05135
uniprot id: U4KS00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1318466:BN854 RS00615
gene id: 1318466:BN854_RS00615
uniprot id: U4KJS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

1318466:BN854 RS05780
gene id: 1318466:BN854_RS05780
uniprot id: U4KQK1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1318466:BN854 RS01230
gene id: 1318466:BN854_RS01230
uniprot id: U4KJT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1318466:BN854 RS02880
gene id: 1318466:BN854_RS02880
uniprot id: U4KKB3
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

1318466:BN854 RS02325
gene id: 1318466:BN854_RS02325
uniprot id: U4KKC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1318466:BN854 RS00850
gene id: 1318466:BN854_RS00850
uniprot id: U4KJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS01170
gene id: 1318466:BN854_RS01170
uniprot id: U4KJZ0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1318466:BN854 RS01785
gene id: 1318466:BN854_RS01785
uniprot id: U4KK07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1318466:BN854 RS05365
gene id: 1318466:BN854_RS05365
uniprot id: U4KLE1
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS05320
gene id: 1318466:BN854_RS05320
uniprot id: U4KLE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1318466:BN854 RS01995
gene id: 1318466:BN854_RS01995
uniprot id: U4KK89
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1318466:BN854 RS05245
gene id: 1318466:BN854_RS05245
uniprot id: U4KLD4
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02855
gene id: 1318466:BN854_RS02855
uniprot id: U4KKB0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1318466:BN854 RS05070
gene id: 1318466:BN854_RS05070
uniprot id: U4KLB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1318466:BN854 RS06800
gene id: 1318466:BN854_RS06800
uniprot id: U4KLV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1318466:BN854 RS07270
gene id: 1318466:BN854_RS07270
uniprot id: U4KM21
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1318466:BN854 RS00270
gene id: 1318466:BN854_RS00270
uniprot id: U4KJN8
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1318466:BN854 RS02865
gene id: 1318466:BN854_RS02865
uniprot id: U4KRG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS07120
gene id: 1318466:BN854_RS07120
uniprot id: U4KLU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1318466:BN854 RS02070
gene id: 1318466:BN854_RS02070
uniprot id: U4KK96
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1318466:BN854 RS02505
gene id: 1318466:BN854_RS02505
uniprot id: U4KKG9
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02175
gene id: 1318466:BN854_RS02175
uniprot id: U4KP64
names: Similarity
messages: Belongs to the CvfB family.

1318466:BN854 RS03695
gene id: 1318466:BN854_RS03695
uniprot id: U4KKU0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1318466:BN854 RS02110
gene id: 1318466:BN854_RS02110
uniprot id: U4KK36
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS06115
gene id: 1318466:BN854_RS06115
uniprot id: U4KKX8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS01895
gene id: 1318466:BN854_RS01895
uniprot id: U4KK79
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS07070
gene id: 1318466:BN854_RS07070
uniprot id: U4KLU3
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1318466:BN854 RS05360
gene id: 1318466:BN854_RS05360
uniprot id: U4KS17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1318466:BN854 RS06790
gene id: 1318466:BN854_RS06790
uniprot id: U4KQP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1318466:BN854 RS04950
gene id: 1318466:BN854_RS04950
uniprot id: U4KL16
names: Similarity
messages: Belongs to the aldose epimerase family.

1318466:BN854 RS02870
gene id: 1318466:BN854_RS02870
uniprot id: U4KKJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS00005
gene id: 1318466:BN854_RS00005
uniprot id: U4KJL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1318466:BN854 RS00670
gene id: 1318466:BN854_RS00670
uniprot id: U4KJU1
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1318466:BN854 RS02830
gene id: 1318466:BN854_RS02830
uniprot id: U4KKA7
names: Similarity
messages: Belongs to the peptidase U62 family.

1318466:BN854 RS06240
gene id: 1318466:BN854_RS06240
uniprot id: U4KLI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1318466:BN854 RS02430
gene id: 1318466:BN854_RS02430
uniprot id: U4KKG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1318466:BN854 RS07110
gene id: 1318466:BN854_RS07110
uniprot id: U4KLX9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1318466:BN854 RS04565
gene id: 1318466:BN854_RS04565
uniprot id: U4KL45
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1318466:BN854 RS02540
gene id: 1318466:BN854_RS02540
uniprot id: U4KPC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1318466:BN854 RS01525
gene id: 1318466:BN854_RS01525
uniprot id: U4KNS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1318466:BN854 RS01605
gene id: 1318466:BN854_RS01605
uniprot id: U4KK44
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1318466:BN854 RS06685
gene id: 1318466:BN854_RS06685
uniprot id: U4KLP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1318466:BN854 RS06270
gene id: 1318466:BN854_RS06270
uniprot id: U4KQM1
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1318466:BN854 RS03645
gene id: 1318466:BN854_RS03645
uniprot id: U4KKT5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1318466:BN854 RS07360
gene id: 1318466:BN854_RS07360
uniprot id: U4KJJ9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1318466:BN854 RS06100
gene id: 1318466:BN854_RS06100
uniprot id: U4KQL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1318466:BN854 RS05150
gene id: 1318466:BN854_RS05150
uniprot id: U4KL41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1318466:BN854 RS00300
gene id: 1318466:BN854_RS00300
uniprot id: U4KJQ0
names: Similarity
messages: Belongs to the peptidase S51 family.

1318466:BN854 RS02305
gene id: 1318466:BN854_RS02305
uniprot id: U4KKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1318466:BN854 RS06175
gene id: 1318466:BN854_RS06175
uniprot id: U4KQL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1318466:BN854 RS06735
gene id: 1318466:BN854_RS06735
uniprot id: U4KLR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1318466:BN854 RS04695
gene id: 1318466:BN854_RS04695
uniprot id: U4KL73
names: Similarity
messages: Belongs to the ribF family.

1318466:BN854 RS06780
gene id: 1318466:BN854_RS06780
uniprot id: U4KLX5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1318466:BN854 RS06375
gene id: 1318466:BN854_RS06375
uniprot id: U4KS92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1318466:BN854 RS02605
gene id: 1318466:BN854_RS02605
uniprot id: U4KKI1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1318466:BN854 RS01470
gene id: 1318466:BN854_RS01470
uniprot id: U4KK28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1318466:BN854 RS03325
gene id: 1318466:BN854_RS03325
uniprot id: U4KRJ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1318466:BN854 RS02055
gene id: 1318466:BN854_RS02055
uniprot id: U4KK31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1318466:BN854 RS06050
gene id: 1318466:BN854_RS06050
uniprot id: U4KQL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1318466:BN854 RS05555
gene id: 1318466:BN854_RS05555
uniprot id: U4KLG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1318466:BN854 RS06295
gene id: 1318466:BN854_RS06295
uniprot id: U4KQM2
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1318466:BN854 RS07495
gene id: 1318466:BN854_RS07495
uniprot id: U4KLJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1318466:BN854 RS04080
gene id: 1318466:BN854_RS04080
uniprot id: U4KKZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1318466:BN854 RS03495
gene id: 1318466:BN854_RS03495
uniprot id: U4KKR7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS04570
gene id: 1318466:BN854_RS04570
uniprot id: U4KL60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1318466:BN854 RS07890
gene id: 1318466:BN854_RS07890
uniprot id: U4KLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

1318466:BN854 RS06075
gene id: 1318466:BN854_RS06075
uniprot id: U4KQL3
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1318466:BN854 RS04865
gene id: 1318466:BN854_RS04865
uniprot id: U4KL80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1318466:BN854 RS02620
gene id: 1318466:BN854_RS02620
uniprot id: U4KRE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS03685
gene id: 1318466:BN854_RS03685
uniprot id: U4KPU0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1318466:BN854 RS02920
gene id: 1318466:BN854_RS02920
uniprot id: U4KKJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1318466:BN854 RS05120
gene id: 1318466:BN854_RS05120
uniprot id: U4KLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1318466:BN854 RS06955
gene id: 1318466:BN854_RS06955
uniprot id: U4KSE6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1318466:BN854 RS05290
gene id: 1318466:BN854_RS05290
uniprot id: U4KLD2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1318466:BN854 RS04910
gene id: 1318466:BN854_RS04910
uniprot id: U4KRY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS05565
gene id: 1318466:BN854_RS05565
uniprot id: U4KQJ2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1318466:BN854 RS02895
gene id: 1318466:BN854_RS02895
uniprot id: U4KKJ6
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1318466:BN854 RS01360
gene id: 1318466:BN854_RS01360
uniprot id: U4KNQ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1318466:BN854 RS06320
gene id: 1318466:BN854_RS06320
uniprot id: U4KQM3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1318466:BN854 RS03595
gene id: 1318466:BN854_RS03595
uniprot id: U4KKS9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1318466:BN854 RS06010
gene id: 1318466:BN854_RS06010
uniprot id: U4KLL7
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1318466:BN854 RS00640
gene id: 1318466:BN854_RS00640
uniprot id: U4KJS9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1318466:BN854 RS07520
gene id: 1318466:BN854_RS07520
uniprot id: U4KSH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS05115
gene id: 1318466:BN854_RS05115
uniprot id: U4KLB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 2 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1318466:BN854 RS06360
gene id: 1318466:BN854_RS06360
uniprot id: U4KLQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1318466:BN854 RS03675
gene id: 1318466:BN854_RS03675
uniprot id: U4KKU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1318466:BN854 RS05075
gene id: 1318466:BN854_RS05075
uniprot id: U4KL30
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1318466:BN854 RS00490
gene id: 1318466:BN854_RS00490
uniprot id: U4KQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

1318466:BN854 RS07320
gene id: 1318466:BN854_RS07320
uniprot id: U4KM27
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1318466:BN854 RS00310
gene id: 1318466:BN854_RS00310
uniprot id: U4KN89
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS03945
gene id: 1318466:BN854_RS03945
uniprot id: U4KKX8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS07155
gene id: 1318466:BN854_RS07155
uniprot id: U4KSG2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS06660
gene id: 1318466:BN854_RS06660
uniprot id: U4KLP2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1318466:BN854 RS04995
gene id: 1318466:BN854_RS04995
uniprot id: U4KLA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1318466:BN854 RS06795
gene id: 1318466:BN854_RS06795
uniprot id: U4KSE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1318466:BN854 RS07250
gene id: 1318466:BN854_RS07250
uniprot id: U4KLV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS02815
gene id: 1318466:BN854_RS02815
uniprot id: U4KRG0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS05460
gene id: 1318466:BN854_RS05460
uniprot id: U4KL81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS02435
gene id: 1318466:BN854_RS02435
uniprot id: U4KK62
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

1318466:BN854 RS00290
gene id: 1318466:BN854_RS00290
uniprot id: U4KQV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS03960
gene id: 1318466:BN854_RS03960
uniprot id: U4KRP7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1318466:BN854 RS05380
gene id: 1318466:BN854_RS05380
uniprot id: U4KQI5
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1318466:BN854 RS02230
gene id: 1318466:BN854_RS02230
uniprot id: U4KRB3
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1318466:BN854 RS03005
gene id: 1318466:BN854_RS03005
uniprot id: U4KKD0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS00760
gene id: 1318466:BN854_RS00760
uniprot id: U4KJM2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1318466:BN854 RS05615
gene id: 1318466:BN854_RS05615
uniprot id: U4KQJ4
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS04795
gene id: 1318466:BN854_RS04795
uniprot id: U4KL84
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1318466:BN854 RS06750
gene id: 1318466:BN854_RS06750
uniprot id: U4KLV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1318466:BN854 RS05325
gene id: 1318466:BN854_RS05325
uniprot id: U4KL64
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS01865
gene id: 1318466:BN854_RS01865
uniprot id: U4KR86
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS06770
gene id: 1318466:BN854_RS06770
uniprot id: U4KSD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1318466:BN854 RS03655
gene id: 1318466:BN854_RS03655
uniprot id: U4KKL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1318466:BN854 RS06590
gene id: 1318466:BN854_RS06590
uniprot id: U4KQN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1318466:BN854 RS02080
gene id: 1318466:BN854_RS02080
uniprot id: U4KK34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1318466:BN854 RS06460
gene id: 1318466:BN854_RS06460
uniprot id: U4KLR7
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1318466:BN854 RS00160
gene id: 1318466:BN854_RS00160
uniprot id: U4KJN4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1318466:BN854 RS02095
gene id: 1318466:BN854_RS02095
uniprot id: U4KK99
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1318466:BN854 RS06070
gene id: 1318466:BN854_RS06070
uniprot id: U4KLG3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1318466:BN854 RS03350
gene id: 1318466:BN854_RS03350
uniprot id: U4KRK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1318466:BN854 RS04860
gene id: 1318466:BN854_RS04860
uniprot id: U4KRX8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1318466:BN854 RS04075
gene id: 1318466:BN854_RS04075
uniprot id: U4KKY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1318466:BN854 RS07180
gene id: 1318466:BN854_RS07180
uniprot id: U4KQQ4
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS01100
gene id: 1318466:BN854_RS01100
uniprot id: U4KJY6
names: Similarity
messages: Belongs to the XFP family.

1318466:BN854 RS04510
gene id: 1318466:BN854_RS04510
uniprot id: U4KRV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

1318466:BN854 RS02220
gene id: 1318466:BN854_RS02220
uniprot id: U4KK45
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

1318466:BN854 RS06020
gene id: 1318466:BN854_RS06020
uniprot id: U4KLF7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS00780
gene id: 1318466:BN854_RS00780
uniprot id: U4KJV2
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1318466:BN854 RS05560
gene id: 1318466:BN854_RS05560
uniprot id: U4KL95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1318466:BN854 RS07565
gene id: 1318466:BN854_RS07565
uniprot id: U4KKV0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1318466:BN854 RS02225
gene id: 1318466:BN854_RS02225
uniprot id: U4KP72
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

1318466:BN854 RS06430
gene id: 1318466:BN854_RS06430
uniprot id: U4KLR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1318466:BN854 RS03440
gene id: 1318466:BN854_RS03440
uniprot id: U4KPP8
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS01310
gene id: 1318466:BN854_RS01310
uniprot id: U4KNQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1318466:BN854 RS05910
gene id: 1318466:BN854_RS05910
uniprot id: U4KS58
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02805
gene id: 1318466:BN854_RS02805
uniprot id: U4KKA4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

1318466:BN854 RS06305
gene id: 1318466:BN854_RS06305
uniprot id: U4KLQ0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS02675
gene id: 1318466:BN854_RS02675
uniprot id: U4KKG8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS04545
gene id: 1318466:BN854_RS04545
uniprot id: U4KL57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1318466:BN854 RS06720
gene id: 1318466:BN854_RS06720
uniprot id: U4KSD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1318466:BN854 RS02575
gene id: 1318466:BN854_RS02575
uniprot id: U4KKF6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS02015
gene id: 1318466:BN854_RS02015
uniprot id: U4KR97
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS01255
gene id: 1318466:BN854_RS01255
uniprot id: U4KJT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

1318466:BN854 RS07100
gene id: 1318466:BN854_RS07100
uniprot id: U4KQQ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

1318466:BN854 RS03605
gene id: 1318466:BN854_RS03605
uniprot id: U4KKK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1318466:BN854 RS00295
gene id: 1318466:BN854_RS00295
uniprot id: U4KJP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1318466:BN854 RS05630
gene id: 1318466:BN854_RS05630
uniprot id: U4KLH6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS02490
gene id: 1318466:BN854_RS02490
uniprot id: U4KPB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1318466:BN854 RS07115
gene id: 1318466:BN854_RS07115
uniprot id: U4KM03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1318466:BN854 RS00035
gene id: 1318466:BN854_RS00035
uniprot id: U4KJM1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1318466:BN854 RS06250
gene id: 1318466:BN854_RS06250
uniprot id: U4KS86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

1318466:BN854 RS01845
gene id: 1318466:BN854_RS01845
uniprot id: U4KK75
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1318466:BN854 RS04435
gene id: 1318466:BN854_RS04435
uniprot id: U4KRU6
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1318466:BN854 RS04335
gene id: 1318466:BN854_RS04335
uniprot id: U4KRT9
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS04255
gene id: 1318466:BN854_RS04255
uniprot id: U4KKU8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1318466:BN854 RS06370
gene id: 1318466:BN854_RS06370
uniprot id: U4KQM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1318466:BN854 RS02975
gene id: 1318466:BN854_RS02975
uniprot id: U4KKM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1318466:BN854 RS02180
gene id: 1318466:BN854_RS02180
uniprot id: U4KRA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS02780
gene id: 1318466:BN854_RS02780
uniprot id: U4KKA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1318466:BN854 RS06205
gene id: 1318466:BN854_RS06205
uniprot id: U4KLP0
names: Similarity
messages: Belongs to the IMPACT family.

1318466:BN854 RS04720
gene id: 1318466:BN854_RS04720
uniprot id: U4KL76
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1318466:BN854 RS07065
gene id: 1318466:BN854_RS07065
uniprot id: U4KLZ8
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1318466:BN854 RS06505
gene id: 1318466:BN854_RS06505
uniprot id: U4KLS3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1318466:BN854 RS04895
gene id: 1318466:BN854_RS04895
uniprot id: U4KL94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS06740
gene id: 1318466:BN854_RS06740
uniprot id: U4KQP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1318466:BN854 RS07345
gene id: 1318466:BN854_RS07345
uniprot id: U4KM30
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1318466:BN854 RS06680
gene id: 1318466:BN854_RS06680
uniprot id: U4KLU4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1318466:BN854 RS02085
gene id: 1318466:BN854_RS02085
uniprot id: U4KP52
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

1318466:BN854 RS06415
gene id: 1318466:BN854_RS06415
uniprot id: U4KLK9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1318466:BN854 RS03760
gene id: 1318466:BN854_RS03760
uniprot id: U4KPV1
names: Similarity
messages: Belongs to the peptidase S51 family.

1318466:BN854 RS00775
gene id: 1318466:BN854_RS00775
uniprot id: U4KJU5
names: Similarity
messages: Belongs to the peptidase C15 family.

1318466:BN854 RS06635
gene id: 1318466:BN854_RS06635
uniprot id: U4KLN9
names: Similarity
messages: Belongs to the thioredoxin family.

1318466:BN854 RS04265
gene id: 1318466:BN854_RS04265
uniprot id: U4KRT3
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS05065
gene id: 1318466:BN854_RS05065
uniprot id: U4KLA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1318466:BN854 RS03660
gene id: 1318466:BN854_RS03660
uniprot id: U4KPT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1318466:BN854 RS04465
gene id: 1318466:BN854_RS04465
uniprot id: U4KL33
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1318466:BN854 RS00605
gene id: 1318466:BN854_RS00605
uniprot id: U4KND9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1318466:BN854 RS05980
gene id: 1318466:BN854_RS05980
uniprot id: U4KQK9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1318466:BN854 RS06215
gene id: 1318466:BN854_RS06215
uniprot id: U4KLI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1318466:BN854 RS01375
gene id: 1318466:BN854_RS01375
uniprot id: U4KK17
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1318466:BN854 RS03560
gene id: 1318466:BN854_RS03560
uniprot id: U4KPR8
names: Similarity
messages: Belongs to the Iojap/RsfS family.

1318466:BN854 RS02955
gene id: 1318466:BN854_RS02955
uniprot id: U4KKC4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1318466:BN854 RS06995
gene id: 1318466:BN854_RS06995
uniprot id: U4KLT6
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS04705
gene id: 1318466:BN854_RS04705
uniprot id: U4KQC7
names: Similarity
messages: Belongs to the thioredoxin family.

1318466:BN854 RS01630
gene id: 1318466:BN854_RS01630
uniprot id: U4KK47
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1318466:BN854 RS03045
gene id: 1318466:BN854_RS03045
uniprot id: U4KRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS02290
gene id: 1318466:BN854_RS02290
uniprot id: U4KP82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1318466:BN854 RS02890
gene id: 1318466:BN854_RS02890
uniprot id: U4KRG6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

1318466:BN854 RS06165
gene id: 1318466:BN854_RS06165
uniprot id: U4KLN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1318466:BN854 RS02455
gene id: 1318466:BN854_RS02455
uniprot id: U4KKG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1318466:BN854 RS02235
gene id: 1318466:BN854_RS02235
uniprot id: U4KKB5
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02925
gene id: 1318466:BN854_RS02925
uniprot id: U4KKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1318466:BN854 RS06570
gene id: 1318466:BN854_RS06570
uniprot id: U4KSA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1318466:BN854 RS00015
gene id: 1318466:BN854_RS00015
uniprot id: U4KJI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1318466:BN854 RS05485
gene id: 1318466:BN854_RS05485
uniprot id: U4KL85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS03510
gene id: 1318466:BN854_RS03510
uniprot id: U4KPR1
names: Similarity
messages: Belongs to the UPF0473 family.

1318466:BN854 RS03690
gene id: 1318466:BN854_RS03690
uniprot id: U4KRM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1318466:BN854 RS05835
gene id: 1318466:BN854_RS05835
uniprot id: U4KS52
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

1318466:BN854 RS04920
gene id: 1318466:BN854_RS04920
uniprot id: U4KL97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS05010
gene id: 1318466:BN854_RS05010
uniprot id: U4KRZ0
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1318466:BN854 RS07190
gene id: 1318466:BN854_RS07190
uniprot id: U4KLY7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1318466:BN854 RS01395
gene id: 1318466:BN854_RS01395
uniprot id: U4KK14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1318466:BN854 RS01335
gene id: 1318466:BN854_RS01335
uniprot id: U4KNQ4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1318466:BN854 RS00240
gene id: 1318466:BN854_RS00240
uniprot id: U4KQV2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1318466:BN854 RS05000
gene id: 1318466:BN854_RS05000
uniprot id: U4KL21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1318466:BN854 RS04710
gene id: 1318466:BN854_RS04710
uniprot id: U4KRW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1318466:BN854 RS03890
gene id: 1318466:BN854_RS03890
uniprot id: U4KKV8
names: Similarity
messages: Belongs to the peptidase M24B family.

1318466:BN854 RS03940
gene id: 1318466:BN854_RS03940
uniprot id: U4KKW7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1318466:BN854 RS05985
gene id: 1318466:BN854_RS05985
uniprot id: U4KS64
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS06045
gene id: 1318466:BN854_RS06045
uniprot id: U4KLG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1318466:BN854 RS07830
gene id: 1318466:BN854_RS07830
uniprot id: U4KJT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1318466:BN854 RS03650
gene id: 1318466:BN854_RS03650
uniprot id: U4KKU5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1318466:BN854 RS02845
gene id: 1318466:BN854_RS02845
uniprot id: U4KKJ0
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02445
gene id: 1318466:BN854_RS02445
uniprot id: U4KRD1
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1318466:BN854 RS07075
gene id: 1318466:BN854_RS07075
uniprot id: U4KQQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

1318466:BN854 RS02990
gene id: 1318466:BN854_RS02990
uniprot id: U4KRH3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1318466:BN854 RS02300
gene id: 1318466:BN854_RS02300
uniprot id: U4KKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1318466:BN854 RS04615
gene id: 1318466:BN854_RS04615
uniprot id: U4KL50
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1318466:BN854 RS00675
gene id: 1318466:BN854_RS00675
uniprot id: U4KJL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1318466:BN854 RS06675
gene id: 1318466:BN854_RS06675
uniprot id: U4KLU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1318466:BN854 RS04515
gene id: 1318466:BN854_RS04515
uniprot id: U4KL39
names: Similarity
messages: Belongs to the asparaginase 1 family.

1318466:BN854 RS06000
gene id: 1318466:BN854_RS06000
uniprot id: U4KQL0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS06990
gene id: 1318466:BN854_RS06990
uniprot id: U4KLY9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1318466:BN854 RS01945
gene id: 1318466:BN854_RS01945
uniprot id: U4KK83
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

1318466:BN854 RS06760
gene id: 1318466:BN854_RS06760
uniprot id: U4KLR9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1318466:BN854 RS05635
gene id: 1318466:BN854_RS05635
uniprot id: U4KLA5
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1318466:BN854 RS06235
gene id: 1318466:BN854_RS06235
uniprot id: U4KLP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1318466:BN854 RS04970
gene id: 1318466:BN854_RS04970
uniprot id: U4KLA3
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

1318466:BN854 RS01270
gene id: 1318466:BN854_RS01270
uniprot id: U4KJZ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1318466:BN854 RS00500
gene id: 1318466:BN854_RS00500
uniprot id: U4KJS2
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

1318466:BN854 RS06440
gene id: 1318466:BN854_RS06440
uniprot id: U4KLL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1318466:BN854 RS06365
gene id: 1318466:BN854_RS06365
uniprot id: U4KLK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1318466:BN854 RS04560
gene id: 1318466:BN854_RS04560
uniprot id: U4KRV5
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1318466:BN854 RS02020
gene id: 1318466:BN854_RS02020
uniprot id: U4KK91
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1318466:BN854 RS04815
gene id: 1318466:BN854_RS04815
uniprot id: U4KL74
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1318466:BN854 RS02905
gene id: 1318466:BN854_RS02905
uniprot id: U4KKB6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1318466:BN854 RS05430
gene id: 1318466:BN854_RS05430
uniprot id: U4KL78
names: Similarity
messages: Belongs to the TlyA family.

1318466:BN854 RS05680
gene id: 1318466:BN854_RS05680
uniprot id: U4KLI2
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1318466:BN854 RS07205
gene id: 1318466:BN854_RS07205
uniprot id: U4KQQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS07130
gene id: 1318466:BN854_RS07130
uniprot id: U4KSG0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS01000
gene id: 1318466:BN854_RS01000
uniprot id: U4KJQ2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1318466:BN854 RS02825
gene id: 1318466:BN854_RS02825
uniprot id: U4KKK6
names: Similarity
messages: Belongs to the peptidase U62 family.

1318466:BN854 RS07385
gene id: 1318466:BN854_RS07385
uniprot id: U4KR44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1318466:BN854 RS07185
gene id: 1318466:BN854_RS07185
uniprot id: U4KSG4
names: Similarity
messages: Belongs to the RpoE family.

1318466:BN854 RS01430
gene id: 1318466:BN854_RS01430
uniprot id: U4KJV6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1318466:BN854 RS00210
gene id: 1318466:BN854_RS00210
uniprot id: U4KJP0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1318466:BN854 RS03600
gene id: 1318466:BN854_RS03600
uniprot id: U4KKU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1318466:BN854 RS06765
gene id: 1318466:BN854_RS06765
uniprot id: U4KQP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1318466:BN854 RS06785
gene id: 1318466:BN854_RS06785
uniprot id: U4KLS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1318466:BN854 RS03880
gene id: 1318466:BN854_RS03880
uniprot id: U4KPW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS07105
gene id: 1318466:BN854_RS07105
uniprot id: U4KSF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1318466:BN854 RS02005
gene id: 1318466:BN854_RS02005
uniprot id: U4KK27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1318466:BN854 RS02985
gene id: 1318466:BN854_RS02985
uniprot id: U4KPJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1318466:BN854 RS02150
gene id: 1318466:BN854_RS02150
uniprot id: U4KP61
names: Subcellular Location Annotation
messages: Cytoplasm

1318466:BN854 RS06715
gene id: 1318466:BN854_RS06715
uniprot id: U4KQN9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1318466:BN854 RS04525
gene id: 1318466:BN854_RS04525
uniprot id: U4KKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1318466:BN854 RS04975
gene id: 1318466:BN854_RS04975
uniprot id: U4KL19
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1318466:BN854 RS02200
gene id: 1318466:BN854_RS02200
uniprot id: U4KP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1318466:BN854 RS02545
gene id: 1318466:BN854_RS02545
uniprot id: U4KRD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1318466:BN854 RS07195
gene id: 1318466:BN854_RS07195
uniprot id: U4KM12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1318466:BN854 RS00910
gene id: 1318466:BN854_RS00910
uniprot id: U4KNI9
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Tetramer of two alpha and two beta subunits.

1318466:BN854 RS03030
gene id: 1318466:BN854_RS03030
uniprot id: U4KKM8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1318466:BN854 RS01315
gene id: 1318466:BN854_RS01315
uniprot id: U4KR35
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1318466:BN854 RS04700
gene id: 1318466:BN854_RS04700
uniprot id: U4KKZ4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1318466:BN854 RS06745
gene id: 1318466:BN854_RS06745
uniprot id: U4KSD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1318466:BN854 RS06510
gene id: 1318466:BN854_RS06510
uniprot id: U4KLM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1318466:BN854 RS01295
gene id: 1318466:BN854_RS01295
uniprot id: U4KK01
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1318466:BN854 RS02385
gene id: 1318466:BN854_RS02385
uniprot id: U4KK59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

1318466:BN854 RS01570
gene id: 1318466:BN854_RS01570
uniprot id: U4KR51
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1318466:BN854 RS00305
gene id: 1318466:BN854_RS00305
uniprot id: U4KJJ8
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS03010
gene id: 1318466:BN854_RS03010
uniprot id: U4KPJ4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1318466:BN854 RS02410
gene id: 1318466:BN854_RS02410
uniprot id: U4KK61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1318466:BN854 RS04395
gene id: 1318466:BN854_RS04395
uniprot id: U4KL40
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1318466:BN854 RS06775
gene id: 1318466:BN854_RS06775
uniprot id: U4KLV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1318466:BN854 RS04915
gene id: 1318466:BN854_RS04915
uniprot id: U4KL87
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1318466:BN854 RS06140
gene id: 1318466:BN854_RS06140
uniprot id: U4KLN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1318466:BN854 RS02965
gene id: 1318466:BN854_RS02965
uniprot id: U4KRH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1318466:BN854 RS03220
gene id: 1318466:BN854_RS03220
uniprot id: U4KPM1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1318466:BN854 RS00515
gene id: 1318466:BN854_RS00515
uniprot id: U4KQX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1318466:BN854 RS04450
gene id: 1318466:BN854_RS04450
uniprot id: U4KKW9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1318466:BN854 RS04640
gene id: 1318466:BN854_RS04640
uniprot id: U4KL53
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS05260
gene id: 1318466:BN854_RS05260
uniprot id: U4KS09
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS02525
gene id: 1318466:BN854_RS02525
uniprot id: U4KKE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1318466:BN854 RS02335
gene id: 1318466:BN854_RS02335
uniprot id: U4KK56
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1318466:BN854 RS03455
gene id: 1318466:BN854_RS03455
uniprot id: U4KKS7
names: Subcellular Location Annotation
messages: Membrane

1318466:BN854 RS06730
gene id: 1318466:BN854_RS06730
uniprot id: U4KLX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1318466:BN854 RS03115
gene id: 1318466:BN854_RS03115
uniprot id: U4KRI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1318466:BN854 RS07440
gene id: 1318466:BN854_RS07440
uniprot id: U4KKM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1318466:BN854 RS00620
gene id: 1318466:BN854_RS00620
uniprot id: U4KJT5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1318466:BN854 RS06690
gene id: 1318466:BN854_RS06690
uniprot id: U4KQN8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1318466:BN854 RS05465
gene id: 1318466:BN854_RS05465
uniprot id: U4KQI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1318466:BN854 RS04410
gene id: 1318466:BN854_RS04410
uniprot id: U4KRU4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1318466:BN854 RS04965
gene id: 1318466:BN854_RS04965
uniprot id: U4KL93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

1318466:BN854 RS00030
gene id: 1318466:BN854_RS00030
uniprot id: U4KJL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.