1307763:L21SP4 RS04795
gene id: 1307763:L21SP4_RS04795
uniprot id: A0A0G3EFQ4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1307763:L21SP4 RS11700
gene id: 1307763:L21SP4_RS11700
uniprot id: A0A0G3EJJ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1307763:L21SP4 RS02580
gene id: 1307763:L21SP4_RS02580
uniprot id: A0A0G3EBW9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307763:L21SP4 RS06550
gene id: 1307763:L21SP4_RS06550
uniprot id: A0A0G3EE45
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS06080
gene id: 1307763:L21SP4_RS06080
uniprot id: A0A0G3EDE1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00065
gene id: 1307763:L21SP4_RS00065
uniprot id: A0A0G3EAM5
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1307763:L21SP4 RS05760
gene id: 1307763:L21SP4_RS05760
uniprot id: A0A0G3EDM6
names: Similarity
messages: Belongs to the Skp family.

1307763:L21SP4 RS05090
gene id: 1307763:L21SP4_RS05090
uniprot id: A0A0G3EHH6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1307763:L21SP4 RS10645
gene id: 1307763:L21SP4_RS10645
uniprot id: A0A0G3EMR8
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1307763:L21SP4 RS05415
gene id: 1307763:L21SP4_RS05415
uniprot id: A0A0G3EG45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1307763:L21SP4 RS07165
gene id: 1307763:L21SP4_RS07165
uniprot id: A0A0G3EE26
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1307763:L21SP4 RS10275
gene id: 1307763:L21SP4_RS10275
uniprot id: A0A0G3EMJ6
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

1307763:L21SP4 RS06190
gene id: 1307763:L21SP4_RS06190
uniprot id: A0A0G3EK41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1307763:L21SP4 RS08030
gene id: 1307763:L21SP4_RS08030
uniprot id: A0A0G3EL76
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1307763:L21SP4 RS08900
gene id: 1307763:L21SP4_RS08900
uniprot id: A0A0G3EFD9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS11635
gene id: 1307763:L21SP4_RS11635
uniprot id: A0A0G3EGX1
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS06760
gene id: 1307763:L21SP4_RS06760
uniprot id: A0A0G3EDU8
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1307763:L21SP4 RS07640
gene id: 1307763:L21SP4_RS07640
uniprot id: A0A0G3EJ53
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflK subfamily.

1307763:L21SP4 RS02585
gene id: 1307763:L21SP4_RS02585
uniprot id: A0A0G3EI44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1307763:L21SP4 RS02485
gene id: 1307763:L21SP4_RS02485
uniprot id: A0A0G3EHW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS13210
gene id: 1307763:L21SP4_RS13210
uniprot id: A0A0G3ECQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS11390
gene id: 1307763:L21SP4_RS11390
uniprot id: A0A0G3EGS2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1307763:L21SP4 RS04010
gene id: 1307763:L21SP4_RS04010
uniprot id: A0A0G3EH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

1307763:L21SP4 RS04215
gene id: 1307763:L21SP4_RS04215
uniprot id: A0A0G3EC88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1307763:L21SP4 RS06715
gene id: 1307763:L21SP4_RS06715
uniprot id: A0A0G3EGS0
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07240
gene id: 1307763:L21SP4_RS07240
uniprot id: A0A0G3EE42
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS04655
gene id: 1307763:L21SP4_RS04655
uniprot id: A0A0G3ED24
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

1307763:L21SP4 RS05125
gene id: 1307763:L21SP4_RS05125
uniprot id: A0A0G3ECW5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS07050
gene id: 1307763:L21SP4_RS07050
uniprot id: A0A0G3EED2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1307763:L21SP4 RS07110
gene id: 1307763:L21SP4_RS07110
uniprot id: A0A0G3EIP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1307763:L21SP4 RS04135
gene id: 1307763:L21SP4_RS04135
uniprot id: A0A0G3EH26
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS11035
gene id: 1307763:L21SP4_RS11035
uniprot id: A0A0G3EGK6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS06200
gene id: 1307763:L21SP4_RS06200
uniprot id: A0A0G3EDF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1307763:L21SP4 RS02155
gene id: 1307763:L21SP4_RS02155
uniprot id: A0A0G3EBM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1307763:L21SP4 RS01290
gene id: 1307763:L21SP4_RS01290
uniprot id: A0A0G3EHA9
names: Similarity
messages: Belongs to the GSP E family.

1307763:L21SP4 RS03620
gene id: 1307763:L21SP4_RS03620
uniprot id: A0A0G3EF05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1307763:L21SP4 RS07125
gene id: 1307763:L21SP4_RS07125
uniprot id: A0A0G3EEE3
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

1307763:L21SP4 RS11090
gene id: 1307763:L21SP4_RS11090
uniprot id: A0A0G3EMY3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1307763:L21SP4 RS09300
gene id: 1307763:L21SP4_RS09300
uniprot id: A0A0G3EFK9
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06905
gene id: 1307763:L21SP4_RS06905
uniprot id: A0A0G3EKF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1307763:L21SP4 RS01970
gene id: 1307763:L21SP4_RS01970
uniprot id: A0A0G3EB14
names: Similarity
messages: Belongs to the UPF0047 family.

1307763:L21SP4 RS01020
gene id: 1307763:L21SP4_RS01020
uniprot id: A0A0G3EAK4
names: Similarity
messages: Belongs to the TrpF family.

1307763:L21SP4 RS02865
gene id: 1307763:L21SP4_RS02865
uniprot id: A0A0G3EC49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1307763:L21SP4 RS03895
gene id: 1307763:L21SP4_RS03895
uniprot id: A0A0G3EIR9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1307763:L21SP4 RS02960
gene id: 1307763:L21SP4_RS02960
uniprot id: A0A0G3EER5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307763:L21SP4 RS04840
gene id: 1307763:L21SP4_RS04840
uniprot id: A0A0G3EHD0
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS02430
gene id: 1307763:L21SP4_RS02430
uniprot id: A0A0G3EBU2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

1307763:L21SP4 RS08630
gene id: 1307763:L21SP4_RS08630
uniprot id: A0A0G3ELI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1307763:L21SP4 RS01765
gene id: 1307763:L21SP4_RS01765
uniprot id: A0A0G3EAX3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS03635
gene id: 1307763:L21SP4_RS03635
uniprot id: A0A0G3EGS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1307763:L21SP4 RS06255
gene id: 1307763:L21SP4_RS06255
uniprot id: A0A0G3EGI7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

1307763:L21SP4 RS02735
gene id: 1307763:L21SP4_RS02735
uniprot id: A0A0G3EC26
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1307763:L21SP4 RS01230
gene id: 1307763:L21SP4_RS01230
uniprot id: A0A0G3EDQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1307763:L21SP4 RS13050
gene id: 1307763:L21SP4_RS13050
uniprot id: A0A0G3EFX9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1307763:L21SP4 RS08450
gene id: 1307763:L21SP4_RS08450
uniprot id: A0A0G3EEQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1307763:L21SP4 RS10685
gene id: 1307763:L21SP4_RS10685
uniprot id: A0A0G3EJ04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1307763:L21SP4 RS04900
gene id: 1307763:L21SP4_RS04900
uniprot id: A0A0G3ED59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS02165
gene id: 1307763:L21SP4_RS02165
uniprot id: A0A0G3EFX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1307763:L21SP4 RS08830
gene id: 1307763:L21SP4_RS08830
uniprot id: A0A0G3EF11
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

1307763:L21SP4 RS09235
gene id: 1307763:L21SP4_RS09235
uniprot id: A0A0G3EK02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1307763:L21SP4 RS03935
gene id: 1307763:L21SP4_RS03935
uniprot id: A0A0G3EF68
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1307763:L21SP4 RS00860
gene id: 1307763:L21SP4_RS00860
uniprot id: A0A0G3EH47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1307763:L21SP4 RS00145
gene id: 1307763:L21SP4_RS00145
uniprot id: A0A0G3EAN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1307763:L21SP4 RS07960
gene id: 1307763:L21SP4_RS07960
uniprot id: A0A0G3EJB2
names: Similarity
messages: Belongs to the Fur family.

1307763:L21SP4 RS03750
gene id: 1307763:L21SP4_RS03750
uniprot id: A0A0G3EGU8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1307763:L21SP4 RS00375
gene id: 1307763:L21SP4_RS00375
uniprot id: A0A0G3EDC0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS05785
gene id: 1307763:L21SP4_RS05785
uniprot id: A0A0G3EDN0
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1307763:L21SP4 RS00200
gene id: 1307763:L21SP4_RS00200
uniprot id: A0A0G3EAP9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1307763:L21SP4 RS05380
gene id: 1307763:L21SP4_RS05380
uniprot id: A0A0G3EJQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

1307763:L21SP4 RS03460
gene id: 1307763:L21SP4_RS03460
uniprot id: A0A0G3ECF3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1307763:L21SP4 RS08335
gene id: 1307763:L21SP4_RS08335
uniprot id: A0A0G3EF31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1307763:L21SP4 RS05470
gene id: 1307763:L21SP4_RS05470
uniprot id: A0A0G3EJS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1307763:L21SP4 RS02345
gene id: 1307763:L21SP4_RS02345
uniprot id: A0A0G3EEB3
names: Similarity
messages: Belongs to the asparagine synthetase family.

1307763:L21SP4 RS09570
gene id: 1307763:L21SP4_RS09570
uniprot id: A0A0G3EK51
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1307763:L21SP4 RS08425
gene id: 1307763:L21SP4_RS08425
uniprot id: A0A0G3EEQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1307763:L21SP4 RS02915
gene id: 1307763:L21SP4_RS02915
uniprot id: A0A0G3EC57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1307763:L21SP4 RS10170
gene id: 1307763:L21SP4_RS10170
uniprot id: A0A0G3EMH4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1307763:L21SP4 RS00535
gene id: 1307763:L21SP4_RS00535
uniprot id: A0A0G3EGY7
names: Similarity
messages: Belongs to the UPF0102 family.

1307763:L21SP4 RS12170
gene id: 1307763:L21SP4_RS12170
uniprot id: A0A0G3ENI5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1307763:L21SP4 RS05635
gene id: 1307763:L21SP4_RS05635
uniprot id: A0A0G3EDK7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1307763:L21SP4 RS04560
gene id: 1307763:L21SP4_RS04560
uniprot id: A0A0G3ECF9
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07710
gene id: 1307763:L21SP4_RS07710
uniprot id: A0A0G3EL19
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS05395
gene id: 1307763:L21SP4_RS05395
uniprot id: A0A0G3EG43
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00820
gene id: 1307763:L21SP4_RS00820
uniprot id: A0A0G3EDJ0
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS02405
gene id: 1307763:L21SP4_RS02405
uniprot id: A0A0G3EBT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1307763:L21SP4 RS02630
gene id: 1307763:L21SP4_RS02630
uniprot id: A0A0G3EC08
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS09685
gene id: 1307763:L21SP4_RS09685
uniprot id: A0A0G3EFS6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1307763:L21SP4 RS11640
gene id: 1307763:L21SP4_RS11640
uniprot id: A0A0G3EN76
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS02840
gene id: 1307763:L21SP4_RS02840
uniprot id: A0A0G3EC45
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

1307763:L21SP4 RS08275
gene id: 1307763:L21SP4_RS08275
uniprot id: A0A0G3EEN2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1307763:L21SP4 RS06900
gene id: 1307763:L21SP4_RS06900
uniprot id: A0A0G3EEB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1307763:L21SP4 RS07425
gene id: 1307763:L21SP4_RS07425
uniprot id: A0A0G3EIV5
names: Similarity
messages: Belongs to the ParB family.

1307763:L21SP4 RS05485
gene id: 1307763:L21SP4_RS05485
uniprot id: A0A0G3EG55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS03680
gene id: 1307763:L21SP4_RS03680
uniprot id: A0A0G3EIP4
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS04535
gene id: 1307763:L21SP4_RS04535
uniprot id: A0A0G3EFL1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS11410
gene id: 1307763:L21SP4_RS11410
uniprot id: A0A0G3EJE3
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS08700
gene id: 1307763:L21SP4_RS08700
uniprot id: A0A0G3ELJ5
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS05030
gene id: 1307763:L21SP4_RS05030
uniprot id: A0A0G3EJD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS06070
gene id: 1307763:L21SP4_RS06070
uniprot id: A0A0G3EK23
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS04320
gene id: 1307763:L21SP4_RS04320
uniprot id: A0A0G3EFG7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1307763:L21SP4 RS10230
gene id: 1307763:L21SP4_RS10230
uniprot id: A0A0G3EKN7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1307763:L21SP4 RS10695
gene id: 1307763:L21SP4_RS10695
uniprot id: A0A0G3EGE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1307763:L21SP4 RS09275
gene id: 1307763:L21SP4_RS09275
uniprot id: A0A0G3EFK4
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08125
gene id: 1307763:L21SP4_RS08125
uniprot id: A0A0G3EF00
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1307763:L21SP4 RS09825
gene id: 1307763:L21SP4_RS09825
uniprot id: A0A0G3EM46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1307763:L21SP4 RS03965
gene id: 1307763:L21SP4_RS03965
uniprot id: A0A0G3ECP7
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1307763:L21SP4 RS09900
gene id: 1307763:L21SP4_RS09900
uniprot id: A0A0G3EII6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1307763:L21SP4 RS11175
gene id: 1307763:L21SP4_RS11175
uniprot id: A0A0G3EGB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1307763:L21SP4 RS10265
gene id: 1307763:L21SP4_RS10265
uniprot id: A0A0G3EIU8
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1307763:L21SP4 RS06250
gene id: 1307763:L21SP4_RS06250
uniprot id: A0A0G3EDH3
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

1307763:L21SP4 RS07615
gene id: 1307763:L21SP4_RS07615
uniprot id: A0A0G3EJ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1307763:L21SP4 RS05080
gene id: 1307763:L21SP4_RS05080
uniprot id: A0A0G3ED91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1307763:L21SP4 RS03920
gene id: 1307763:L21SP4_RS03920
uniprot id: A0A0G3EIS2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1307763:L21SP4 RS03415
gene id: 1307763:L21SP4_RS03415
uniprot id: A0A0G3EIK2
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

1307763:L21SP4 RS04115
gene id: 1307763:L21SP4_RS04115
uniprot id: A0A0G3EC74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1307763:L21SP4 RS04280
gene id: 1307763:L21SP4_RS04280
uniprot id: A0A0G3EIY8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1307763:L21SP4 RS07035
gene id: 1307763:L21SP4_RS07035
uniprot id: A0A0G3EIN9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1307763:L21SP4 RS10510
gene id: 1307763:L21SP4_RS10510
uniprot id: A0A0G3EMP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS09935
gene id: 1307763:L21SP4_RS09935
uniprot id: A0A0G3EM72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS11395
gene id: 1307763:L21SP4_RS11395
uniprot id: A0A0G3EN29
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06215
gene id: 1307763:L21SP4_RS06215
uniprot id: A0A0G3EK45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00545
gene id: 1307763:L21SP4_RS00545
uniprot id: A0A0G3EAC4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS10415
gene id: 1307763:L21SP4_RS10415
uniprot id: A0A0G3EKS5
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1307763:L21SP4 RS08090
gene id: 1307763:L21SP4_RS08090
uniprot id: A0A0G3EEK7
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.

1307763:L21SP4 RS05230
gene id: 1307763:L21SP4_RS05230
uniprot id: A0A0G3EHP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1307763:L21SP4 RS01300
gene id: 1307763:L21SP4_RS01300
uniprot id: A0A0G3EAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1307763:L21SP4 RS06745
gene id: 1307763:L21SP4_RS06745
uniprot id: A0A0G3EE82
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1307763:L21SP4 RS11985
gene id: 1307763:L21SP4_RS11985
uniprot id: A0A0G3ENF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS01450
gene id: 1307763:L21SP4_RS01450
uniprot id: A0A0G3EAR6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1307763:L21SP4 RS10965
gene id: 1307763:L21SP4_RS10965
uniprot id: A0A0G3EMW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1307763:L21SP4 RS10535
gene id: 1307763:L21SP4_RS10535
uniprot id: A0A0G3EMP6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1307763:L21SP4 RS06005
gene id: 1307763:L21SP4_RS06005
uniprot id: A0A0G3EK12
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07200
gene id: 1307763:L21SP4_RS07200
uniprot id: A0A0G3EEF1
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS06955
gene id: 1307763:L21SP4_RS06955
uniprot id: A0A0G3EKG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

1307763:L21SP4 RS04205
gene id: 1307763:L21SP4_RS04205
uniprot id: A0A0G3EIX6
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1307763:L21SP4 RS02955
gene id: 1307763:L21SP4_RS02955
uniprot id: A0A0G3EBN9
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1307763:L21SP4 RS07495
gene id: 1307763:L21SP4_RS07495
uniprot id: A0A0G3EKS7
names: Similarity
messages: Belongs to the HsdR family.

1307763:L21SP4 RS10325
gene id: 1307763:L21SP4_RS10325
uniprot id: A0A0G3EMK6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1307763:L21SP4 RS03050
gene id: 1307763:L21SP4_RS03050
uniprot id: A0A0G3EBQ8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1307763:L21SP4 RS04880
gene id: 1307763:L21SP4_RS04880
uniprot id: A0A0G3ED55
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS11895
gene id: 1307763:L21SP4_RS11895
uniprot id: A0A0G3EGQ3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1307763:L21SP4 RS06085
gene id: 1307763:L21SP4_RS06085
uniprot id: A0A0G3EGF5
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1307763:L21SP4 RS05800
gene id: 1307763:L21SP4_RS05800
uniprot id: A0A0G3EDA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1307763:L21SP4 RS06185
gene id: 1307763:L21SP4_RS06185
uniprot id: A0A0G3EDX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1307763:L21SP4 RS06730
gene id: 1307763:L21SP4_RS06730
uniprot id: A0A0G3EII4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS01035
gene id: 1307763:L21SP4_RS01035
uniprot id: A0A0G3EH75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1307763:L21SP4 RS04120
gene id: 1307763:L21SP4_RS04120
uniprot id: A0A0G3EFA4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1307763:L21SP4 RS00190
gene id: 1307763:L21SP4_RS00190
uniprot id: A0A0G3EA59
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1307763:L21SP4 RS03190
gene id: 1307763:L21SP4_RS03190
uniprot id: A0A0G3EBT8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1307763:L21SP4 RS12230
gene id: 1307763:L21SP4_RS12230
uniprot id: A0A0G3EFE8
names: Similarity
messages: Belongs to the rubredoxin family.

1307763:L21SP4 RS05025
gene id: 1307763:L21SP4_RS05025
uniprot id: A0A0G3ED80
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS01865
gene id: 1307763:L21SP4_RS01865
uniprot id: A0A0G3EHJ4
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1307763:L21SP4 RS06950
gene id: 1307763:L21SP4_RS06950
uniprot id: A0A0G3EEB7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS01130
gene id: 1307763:L21SP4_RS01130
uniprot id: A0A0G3EB46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1307763:L21SP4 RS09415
gene id: 1307763:L21SP4_RS09415
uniprot id: A0A0G3ELW5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07610
gene id: 1307763:L21SP4_RS07610
uniprot id: A0A0G3EKZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1307763:L21SP4 RS08550
gene id: 1307763:L21SP4_RS08550
uniprot id: A0A0G3EF70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1307763:L21SP4 RS09355
gene id: 1307763:L21SP4_RS09355
uniprot id: A0A0G3EFM0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1307763:L21SP4 RS03195
gene id: 1307763:L21SP4_RS03195
uniprot id: A0A0G3EEU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

1307763:L21SP4 RS08110
gene id: 1307763:L21SP4_RS08110
uniprot id: A0A0G3EJE4
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1307763:L21SP4 RS08600
gene id: 1307763:L21SP4_RS08600
uniprot id: A0A0G3EF80
names: Similarity
messages: Belongs to the asparagine synthetase family.

1307763:L21SP4 RS04110
gene id: 1307763:L21SP4_RS04110
uniprot id: A0A0G3EH19
names: Similarity
messages: Belongs to the TlyA family.

1307763:L21SP4 RS00335
gene id: 1307763:L21SP4_RS00335
uniprot id: A0A0G3EGV1
names: Similarity
messages: Belongs to the peptidase S16 family.

1307763:L21SP4 RS03045
gene id: 1307763:L21SP4_RS03045
uniprot id: A0A0G3EGH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1307763:L21SP4 RS08240
gene id: 1307763:L21SP4_RS08240
uniprot id: A0A0G3EJG4
names: Similarity
messages: Belongs to the GSP E family.

1307763:L21SP4 RS00355
gene id: 1307763:L21SP4_RS00355
uniprot id: A0A0G3EAS3
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

1307763:L21SP4 RS04575
gene id: 1307763:L21SP4_RS04575
uniprot id: A0A0G3EJ33
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1307763:L21SP4 RS09940
gene id: 1307763:L21SP4_RS09940
uniprot id: A0A0G3EKB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1307763:L21SP4 RS01120
gene id: 1307763:L21SP4_RS01120
uniprot id: A0A0G3EAL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1307763:L21SP4 RS00090
gene id: 1307763:L21SP4_RS00090
uniprot id: A0A0G3EAM9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS11550
gene id: 1307763:L21SP4_RS11550
uniprot id: A0A0G3EGI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1307763:L21SP4 RS08315
gene id: 1307763:L21SP4_RS08315
uniprot id: A0A0G3ELD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1307763:L21SP4 RS05440
gene id: 1307763:L21SP4_RS05440
uniprot id: A0A0G3EG48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1307763:L21SP4 RS00030
gene id: 1307763:L21SP4_RS00030
uniprot id: A0A0G3E9X6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1307763:L21SP4 RS12375
gene id: 1307763:L21SP4_RS12375
uniprot id: A0A0G3EGK5
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1307763:L21SP4 RS08270
gene id: 1307763:L21SP4_RS08270
uniprot id: A0A0G3EJG7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1307763:L21SP4 RS03535
gene id: 1307763:L21SP4_RS03535
uniprot id: A0A0G3EIM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS04800
gene id: 1307763:L21SP4_RS04800
uniprot id: A0A0G3ED42
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1307763:L21SP4 RS10805
gene id: 1307763:L21SP4_RS10805
uniprot id: A0A0G3EG51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1307763:L21SP4 RS09510
gene id: 1307763:L21SP4_RS09510
uniprot id: A0A0G3EFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1307763:L21SP4 RS01520
gene id: 1307763:L21SP4_RS01520
uniprot id: A0A0G3EAT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1307763:L21SP4 RS11600
gene id: 1307763:L21SP4_RS11600
uniprot id: A0A0G3EGJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1307763:L21SP4 RS03955
gene id: 1307763:L21SP4_RS03955
uniprot id: A0A0G3EC52
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS04285
gene id: 1307763:L21SP4_RS04285
uniprot id: A0A0G3EH52
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08650
gene id: 1307763:L21SP4_RS08650
uniprot id: A0A0G3EF88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1307763:L21SP4 RS10105
gene id: 1307763:L21SP4_RS10105
uniprot id: A0A0G3EFQ0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

1307763:L21SP4 RS07680
gene id: 1307763:L21SP4_RS07680
uniprot id: A0A0G3EET9
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS02330
gene id: 1307763:L21SP4_RS02330
uniprot id: A0A0G3EHT8
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1307763:L21SP4 RS08445
gene id: 1307763:L21SP4_RS08445
uniprot id: A0A0G3EJJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1307763:L21SP4 RS12080
gene id: 1307763:L21SP4_RS12080
uniprot id: A0A0G3EJR8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1307763:L21SP4 RS10335
gene id: 1307763:L21SP4_RS10335
uniprot id: A0A0G3EFY9
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

1307763:L21SP4 RS12400
gene id: 1307763:L21SP4_RS12400
uniprot id: A0A0G3EFV0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1307763:L21SP4 RS06800
gene id: 1307763:L21SP4_RS06800
uniprot id: A0A0G3EKD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS03885
gene id: 1307763:L21SP4_RS03885
uniprot id: A0A0G3EF56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1307763:L21SP4 RS04230
gene id: 1307763:L21SP4_RS04230
uniprot id: A0A0G3EIY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307763:L21SP4 RS10710
gene id: 1307763:L21SP4_RS10710
uniprot id: A0A0G3EG38
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

1307763:L21SP4 RS03970
gene id: 1307763:L21SP4_RS03970
uniprot id: A0A0G3EIT3
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1307763:L21SP4 RS00525
gene id: 1307763:L21SP4_RS00525
uniprot id: A0A0G3EDE0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1307763:L21SP4 RS11870
gene id: 1307763:L21SP4_RS11870
uniprot id: A0A0G3EGP8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1307763:L21SP4 RS10240
gene id: 1307763:L21SP4_RS10240
uniprot id: A0A0G3EIU3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1307763:L21SP4 RS06390
gene id: 1307763:L21SP4_RS06390
uniprot id: A0A0G3EIB4
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1307763:L21SP4 RS07770
gene id: 1307763:L21SP4_RS07770
uniprot id: A0A0G3EEH0
names: Similarity
messages: Belongs to the GSP E family.

1307763:L21SP4 RS00310
gene id: 1307763:L21SP4_RS00310
uniprot id: A0A0G3EGU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1307763:L21SP4 RS01975
gene id: 1307763:L21SP4_RS01975
uniprot id: A0A0G3EE39
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS10870
gene id: 1307763:L21SP4_RS10870
uniprot id: A0A0G3EL02
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1307763:L21SP4 RS10720
gene id: 1307763:L21SP4_RS10720
uniprot id: A0A0G3EGE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1307763:L21SP4 RS00400
gene id: 1307763:L21SP4_RS00400
uniprot id: A0A0G3EAT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1307763:L21SP4 RS05095
gene id: 1307763:L21SP4_RS05095
uniprot id: A0A0G3ECR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1307763:L21SP4 RS05020
gene id: 1307763:L21SP4_RS05020
uniprot id: A0A0G3EFU4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1307763:L21SP4 RS00680
gene id: 1307763:L21SP4_RS00680
uniprot id: A0A0G3EH13
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS02490
gene id: 1307763:L21SP4_RS02490
uniprot id: A0A0G3EG23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

1307763:L21SP4 RS05700
gene id: 1307763:L21SP4_RS05700
uniprot id: A0A0G3ED63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1307763:L21SP4 RS00110
gene id: 1307763:L21SP4_RS00110
uniprot id: A0A0G3EA45
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307763:L21SP4 RS03770
gene id: 1307763:L21SP4_RS03770
uniprot id: A0A0G3EIQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1307763:L21SP4 RS08940
gene id: 1307763:L21SP4_RS08940
uniprot id: A0A0G3EF28
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS03805
gene id: 1307763:L21SP4_RS03805
uniprot id: A0A0G3EC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1307763:L21SP4 RS04830
gene id: 1307763:L21SP4_RS04830
uniprot id: A0A0G3ED45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1307763:L21SP4 RS07095
gene id: 1307763:L21SP4_RS07095
uniprot id: A0A0G3EGZ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1307763:L21SP4 RS04965
gene id: 1307763:L21SP4_RS04965
uniprot id: A0A0G3ECN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS05275
gene id: 1307763:L21SP4_RS05275
uniprot id: A0A0G3EDF9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

1307763:L21SP4 RS01180
gene id: 1307763:L21SP4_RS01180
uniprot id: A0A0G3EDP5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1307763:L21SP4 RS00440
gene id: 1307763:L21SP4_RS00440
uniprot id: A0A0G3EF30
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06060
gene id: 1307763:L21SP4_RS06060
uniprot id: A0A0G3EGF0
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1307763:L21SP4 RS00710
gene id: 1307763:L21SP4_RS00710
uniprot id: A0A0G3EAG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1307763:L21SP4 RS12095
gene id: 1307763:L21SP4_RS12095
uniprot id: A0A0G3ELM7
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS03740
gene id: 1307763:L21SP4_RS03740
uniprot id: A0A0G3ECK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1307763:L21SP4 RS10660
gene id: 1307763:L21SP4_RS10660
uniprot id: A0A0G3EJ00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1307763:L21SP4 RS02605
gene id: 1307763:L21SP4_RS02605
uniprot id: A0A0G3EC04
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1307763:L21SP4 RS05335
gene id: 1307763:L21SP4_RS05335
uniprot id: A0A0G3EHS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1307763:L21SP4 RS09050
gene id: 1307763:L21SP4_RS09050
uniprot id: A0A0G3EFG0
names: Similarity
messages: Belongs to the aspartokinase family.

1307763:L21SP4 RS02765
gene id: 1307763:L21SP4_RS02765
uniprot id: A0A0G3EI74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS10570
gene id: 1307763:L21SP4_RS10570
uniprot id: A0A0G3EKV3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1307763:L21SP4 RS09495
gene id: 1307763:L21SP4_RS09495
uniprot id: A0A0G3EK42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1307763:L21SP4 RS03705
gene id: 1307763:L21SP4_RS03705
uniprot id: A0A0G3EIP7
names: Cofactor
names: Similarity
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1307763:L21SP4 RS09010
gene id: 1307763:L21SP4_RS09010
uniprot id: A0A0G3EJV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1307763:L21SP4 RS05410
gene id: 1307763:L21SP4_RS05410
uniprot id: A0A0G3ED25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1307763:L21SP4 RS05615
gene id: 1307763:L21SP4_RS05615
uniprot id: A0A0G3ED52
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1307763:L21SP4 RS08715
gene id: 1307763:L21SP4_RS08715
uniprot id: A0A0G3EHW5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1307763:L21SP4 RS06260
gene id: 1307763:L21SP4_RS06260
uniprot id: A0A0G3EDZ2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

1307763:L21SP4 RS03755
gene id: 1307763:L21SP4_RS03755
uniprot id: A0A0G3EC14
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1307763:L21SP4 RS09230
gene id: 1307763:L21SP4_RS09230
uniprot id: A0A0G3ELS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1307763:L21SP4 RS00325
gene id: 1307763:L21SP4_RS00325
uniprot id: A0A0G3EDB1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1307763:L21SP4 RS09905
gene id: 1307763:L21SP4_RS09905
uniprot id: A0A0G3EFV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1307763:L21SP4 RS01190
gene id: 1307763:L21SP4_RS01190
uniprot id: A0A0G3EH97
names: Similarity
messages: Belongs to the DNA photolyase family.

1307763:L21SP4 RS08465
gene id: 1307763:L21SP4_RS08465
uniprot id: A0A0G3ELF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1307763:L21SP4 RS12480
gene id: 1307763:L21SP4_RS12480
uniprot id: A0A0G3EM27
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1307763:L21SP4 RS00115
gene id: 1307763:L21SP4_RS00115
uniprot id: A0A0G3ED83
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307763:L21SP4 RS00105
gene id: 1307763:L21SP4_RS00105
uniprot id: A0A0G3EEY8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307763:L21SP4 RS06770
gene id: 1307763:L21SP4_RS06770
uniprot id: A0A0G3EE87
names: Similarity
messages: Belongs to the UPF0175 family.

1307763:L21SP4 RS08320
gene id: 1307763:L21SP4_RS08320
uniprot id: A0A0G3EJH5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1307763:L21SP4 RS04170
gene id: 1307763:L21SP4_RS04170
uniprot id: A0A0G3EFB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1307763:L21SP4 RS04060
gene id: 1307763:L21SP4_RS04060
uniprot id: A0A0G3EH09
names: Similarity
messages: Belongs to the threonine synthase family.

1307763:L21SP4 RS00390
gene id: 1307763:L21SP4_RS00390
uniprot id: A0A0G3EA98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS04920
gene id: 1307763:L21SP4_RS04920
uniprot id: A0A0G3EFS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

1307763:L21SP4 RS07705
gene id: 1307763:L21SP4_RS07705
uniprot id: A0A0G3EEU2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1307763:L21SP4 RS03810
gene id: 1307763:L21SP4_RS03810
uniprot id: A0A0G3EF39
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS03855
gene id: 1307763:L21SP4_RS03855
uniprot id: A0A0G3EF49
names: Similarity
messages: Belongs to the HPrK/P family.

1307763:L21SP4 RS04985
gene id: 1307763:L21SP4_RS04985
uniprot id: A0A0G3EHF6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1307763:L21SP4 RS02645
gene id: 1307763:L21SP4_RS02645
uniprot id: A0A0G3EBJ0
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1307763:L21SP4 RS05360
gene id: 1307763:L21SP4_RS05360
uniprot id: A0A0G3EHS5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS04235
gene id: 1307763:L21SP4_RS04235
uniprot id: A0A0G3EH43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1307763:L21SP4 RS03020
gene id: 1307763:L21SP4_RS03020
uniprot id: A0A0G3EGH2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1307763:L21SP4 RS02600
gene id: 1307763:L21SP4_RS02600
uniprot id: A0A0G3EEL6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1307763:L21SP4 RS02290
gene id: 1307763:L21SP4_RS02290
uniprot id: A0A0G3EFZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1307763:L21SP4 RS03175
gene id: 1307763:L21SP4_RS03175
uniprot id: A0A0G3EEU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1307763:L21SP4 RS02750
gene id: 1307763:L21SP4_RS02750
uniprot id: A0A0G3EBK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1307763:L21SP4 RS10075
gene id: 1307763:L21SP4_RS10075
uniprot id: A0A0G3EKD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1307763:L21SP4 RS13250
gene id: 1307763:L21SP4_RS13250
uniprot id: A0A0G3EHH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1307763:L21SP4 RS04020
gene id: 1307763:L21SP4_RS04020
uniprot id: A0A0G3EF85
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1307763:L21SP4 RS03185
gene id: 1307763:L21SP4_RS03185
uniprot id: A0A0G3EIF6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1307763:L21SP4 RS07630
gene id: 1307763:L21SP4_RS07630
uniprot id: A0A0G3EET2
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflK subfamily.

1307763:L21SP4 RS01755
gene id: 1307763:L21SP4_RS01755
uniprot id: A0A0G3EHI1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS00315
gene id: 1307763:L21SP4_RS00315
uniprot id: A0A0G3EF10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1307763:L21SP4 RS00670
gene id: 1307763:L21SP4_RS00670
uniprot id: A0A0G3EDF7
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS08520
gene id: 1307763:L21SP4_RS08520
uniprot id: A0A0G3EF65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1307763:L21SP4 RS05065
gene id: 1307763:L21SP4_RS05065
uniprot id: A0A0G3ECR2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1307763:L21SP4 RS00915
gene id: 1307763:L21SP4_RS00915
uniprot id: A0A0G3EFB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1307763:L21SP4 RS05060
gene id: 1307763:L21SP4_RS05060
uniprot id: A0A0G3EHH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1307763:L21SP4 RS06240
gene id: 1307763:L21SP4_RS06240
uniprot id: A0A0G3EK48
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS00185
gene id: 1307763:L21SP4_RS00185
uniprot id: A0A0G3EEZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1307763:L21SP4 RS05805
gene id: 1307763:L21SP4_RS05805
uniprot id: A0A0G3EGA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS05320
gene id: 1307763:L21SP4_RS05320
uniprot id: A0A0G3EG33
names: Similarity
messages: Belongs to the Fur family.

1307763:L21SP4 RS01265
gene id: 1307763:L21SP4_RS01265
uniprot id: A0A0G3EFH0
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

1307763:L21SP4 RS08130
gene id: 1307763:L21SP4_RS08130
uniprot id: A0A0G3EL99
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06740
gene id: 1307763:L21SP4_RS06740
uniprot id: A0A0G3EGS8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1307763:L21SP4 RS02850
gene id: 1307763:L21SP4_RS02850
uniprot id: A0A0G3EGD9
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08385
gene id: 1307763:L21SP4_RS08385
uniprot id: A0A0G3EF41
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1307763:L21SP4 RS06145
gene id: 1307763:L21SP4_RS06145
uniprot id: A0A0G3EI63
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1307763:L21SP4 RS10940
gene id: 1307763:L21SP4_RS10940
uniprot id: A0A0G3EMW1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1307763:L21SP4 RS02210
gene id: 1307763:L21SP4_RS02210
uniprot id: A0A0G3EHR0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

1307763:L21SP4 RS01685
gene id: 1307763:L21SP4_RS01685
uniprot id: A0A0G3EHH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1307763:L21SP4 RS12165
gene id: 1307763:L21SP4_RS12165
uniprot id: A0A0G3EH72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1307763:L21SP4 RS08325
gene id: 1307763:L21SP4_RS08325
uniprot id: A0A0G3EEP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1307763:L21SP4 RS04365
gene id: 1307763:L21SP4_RS04365
uniprot id: A0A0G3ECB9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1307763:L21SP4 RS10210
gene id: 1307763:L21SP4_RS10210
uniprot id: A0A0G3EIT8
names: Similarity
messages: Belongs to the sigma-54 factor family.

1307763:L21SP4 RS03520
gene id: 1307763:L21SP4_RS03520
uniprot id: A0A0G3EBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS04770
gene id: 1307763:L21SP4_RS04770
uniprot id: A0A0G3EFQ1
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1307763:L21SP4 RS02980
gene id: 1307763:L21SP4_RS02980
uniprot id: A0A0G3EER8
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08765
gene id: 1307763:L21SP4_RS08765
uniprot id: A0A0G3EFB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1307763:L21SP4 RS05830
gene id: 1307763:L21SP4_RS05830
uniprot id: A0A0G3EDA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1307763:L21SP4 RS08080
gene id: 1307763:L21SP4_RS08080
uniprot id: A0A0G3EL86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1307763:L21SP4 RS06935
gene id: 1307763:L21SP4_RS06935
uniprot id: A0A0G3EIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1307763:L21SP4 RS08680
gene id: 1307763:L21SP4_RS08680
uniprot id: A0A0G3EJP0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

1307763:L21SP4 RS04125
gene id: 1307763:L21SP4_RS04125
uniprot id: A0A0G3ECS5
names: Similarity
messages: Belongs to the citrate synthase family.

1307763:L21SP4 RS00125
gene id: 1307763:L21SP4_RS00125
uniprot id: A0A0G3EGR6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1307763:L21SP4 RS12205
gene id: 1307763:L21SP4_RS12205
uniprot id: A0A0G3EGY2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1307763:L21SP4 RS02170
gene id: 1307763:L21SP4_RS02170
uniprot id: A0A0G3EB45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1307763:L21SP4 RS05900
gene id: 1307763:L21SP4_RS05900
uniprot id: A0A0G3EI17
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1307763:L21SP4 RS08875
gene id: 1307763:L21SP4_RS08875
uniprot id: A0A0G3EFD5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1307763:L21SP4 RS03465
gene id: 1307763:L21SP4_RS03465
uniprot id: A0A0G3EIL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

1307763:L21SP4 RS09325
gene id: 1307763:L21SP4_RS09325
uniprot id: A0A0G3EFL4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1307763:L21SP4 RS03800
gene id: 1307763:L21SP4_RS03800
uniprot id: A0A0G3EGV9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1307763:L21SP4 RS08330
gene id: 1307763:L21SP4_RS08330
uniprot id: A0A0G3EHP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1307763:L21SP4 RS06170
gene id: 1307763:L21SP4_RS06170
uniprot id: A0A0G3EI68
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS05390
gene id: 1307763:L21SP4_RS05390
uniprot id: A0A0G3ED20
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1307763:L21SP4 RS05590
gene id: 1307763:L21SP4_RS05590
uniprot id: A0A0G3ED48
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS00345
gene id: 1307763:L21SP4_RS00345
uniprot id: A0A0G3EA89
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

1307763:L21SP4 RS07845
gene id: 1307763:L21SP4_RS07845
uniprot id: A0A0G3EEH7
names: Similarity
messages: Belongs to the DtxR/MntR family.

1307763:L21SP4 RS10185
gene id: 1307763:L21SP4_RS10185
uniprot id: A0A0G3EIS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1307763:L21SP4 RS03865
gene id: 1307763:L21SP4_RS03865
uniprot id: A0A0G3EIR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1307763:L21SP4 RS09870
gene id: 1307763:L21SP4_RS09870
uniprot id: A0A0G3EFK3
names: Similarity
messages: Belongs to the glycosyltransferase 1 family.

1307763:L21SP4 RS07410
gene id: 1307763:L21SP4_RS07410
uniprot id: A0A0G3EH66
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1307763:L21SP4 RS06960
gene id: 1307763:L21SP4_RS06960
uniprot id: A0A0G3EIM9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS00220
gene id: 1307763:L21SP4_RS00220
uniprot id: A0A0G3ED97
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1307763:L21SP4 RS05770
gene id: 1307763:L21SP4_RS05770
uniprot id: A0A0G3EHZ6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1307763:L21SP4 RS08045
gene id: 1307763:L21SP4_RS08045
uniprot id: A0A0G3EHJ8
names: Similarity
messages: Belongs to the GSP E family.

1307763:L21SP4 RS07605
gene id: 1307763:L21SP4_RS07605
uniprot id: A0A0G3EEL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS05775
gene id: 1307763:L21SP4_RS05775
uniprot id: A0A0G3ED99
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1307763:L21SP4 RS03250
gene id: 1307763:L21SP4_RS03250
uniprot id: A0A0G3ECB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1307763:L21SP4 RS02860
gene id: 1307763:L21SP4_RS02860
uniprot id: A0A0G3EEQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1307763:L21SP4 RS01015
gene id: 1307763:L21SP4_RS01015
uniprot id: A0A0G3EFD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1307763:L21SP4 RS07850
gene id: 1307763:L21SP4_RS07850
uniprot id: A0A0G3EHH7
names: Similarity
messages: Belongs to the UPF0751 family.

1307763:L21SP4 RS07350
gene id: 1307763:L21SP4_RS07350
uniprot id: A0A0G3EKP4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1307763:L21SP4 RS01185
gene id: 1307763:L21SP4_RS01185
uniprot id: A0A0G3EB56
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1307763:L21SP4 RS08185
gene id: 1307763:L21SP4_RS08185
uniprot id: A0A0G3ELA7
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

1307763:L21SP4 RS04895
gene id: 1307763:L21SP4_RS04895
uniprot id: A0A0G3ECM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1307763:L21SP4 RS08010
gene id: 1307763:L21SP4_RS08010
uniprot id: A0A0G3EJC2
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08490
gene id: 1307763:L21SP4_RS08490
uniprot id: A0A0G3EHS3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS04160
gene id: 1307763:L21SP4_RS04160
uniprot id: A0A0G3EH30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1307763:L21SP4 RS06660
gene id: 1307763:L21SP4_RS06660
uniprot id: A0A0G3EIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1307763:L21SP4 RS06475
gene id: 1307763:L21SP4_RS06475
uniprot id: A0A0G3EDP6
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1307763:L21SP4 RS03825
gene id: 1307763:L21SP4_RS03825
uniprot id: A0A0G3EC28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1307763:L21SP4 RS02740
gene id: 1307763:L21SP4_RS02740
uniprot id: A0A0G3EI69
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307763:L21SP4 RS09285
gene id: 1307763:L21SP4_RS09285
uniprot id: A0A0G3EK13
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1307763:L21SP4 RS10080
gene id: 1307763:L21SP4_RS10080
uniprot id: A0A0G3EFP7
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1307763:L21SP4 RS03670
gene id: 1307763:L21SP4_RS03670
uniprot id: A0A0G3EF13
names: Subcellular Location Annotation
messages: Periplasm

1307763:L21SP4 RS05255
gene id: 1307763:L21SP4_RS05255
uniprot id: A0A0G3EJM2
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1307763:L21SP4 RS08910
gene id: 1307763:L21SP4_RS08910
uniprot id: A0A0G3EJT8
names: Similarity
messages: Belongs to the alkaline phosphatase family.

1307763:L21SP4 RS08980
gene id: 1307763:L21SP4_RS08980
uniprot id: A0A0G3ELN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1307763:L21SP4 RS02525
gene id: 1307763:L21SP4_RS02525
uniprot id: A0A0G3EED7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1307763:L21SP4 RS02665
gene id: 1307763:L21SP4_RS02665
uniprot id: A0A0G3EGA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

1307763:L21SP4 RS06100
gene id: 1307763:L21SP4_RS06100
uniprot id: A0A0G3EDE4
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1307763:L21SP4 RS05665
gene id: 1307763:L21SP4_RS05665
uniprot id: A0A0G3EJV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1307763:L21SP4 RS01155
gene id: 1307763:L21SP4_RS01155
uniprot id: A0A0G3EDP1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1307763:L21SP4 RS11935
gene id: 1307763:L21SP4_RS11935
uniprot id: A0A0G3ENE0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00060
gene id: 1307763:L21SP4_RS00060
uniprot id: A0A0G3ED49
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS04650
gene id: 1307763:L21SP4_RS04650
uniprot id: A0A0G3EFN0
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS00280
gene id: 1307763:L21SP4_RS00280
uniprot id: A0A0G3EAR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1307763:L21SP4 RS02315
gene id: 1307763:L21SP4_RS02315
uniprot id: A0A0G3EB77
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS01985
gene id: 1307763:L21SP4_RS01985
uniprot id: A0A0G3EHL1
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

1307763:L21SP4 RS04845
gene id: 1307763:L21SP4_RS04845
uniprot id: A0A0G3ECL1
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.

1307763:L21SP4 RS08855
gene id: 1307763:L21SP4_RS08855
uniprot id: A0A0G3EF15
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS01825
gene id: 1307763:L21SP4_RS01825
uniprot id: A0A0G3EAY6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07155
gene id: 1307763:L21SP4_RS07155
uniprot id: A0A0G3EKK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1307763:L21SP4 RS07235
gene id: 1307763:L21SP4_RS07235
uniprot id: A0A0G3EIR4
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1307763:L21SP4 RS09110
gene id: 1307763:L21SP4_RS09110
uniprot id: A0A0G3EF61
names: Similarity
messages: Belongs to the LarC family.

1307763:L21SP4 RS11345
gene id: 1307763:L21SP4_RS11345
uniprot id: A0A0G3EGE7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1307763:L21SP4 RS07560
gene id: 1307763:L21SP4_RS07560
uniprot id: A0A0G3EH89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1307763:L21SP4 RS00035
gene id: 1307763:L21SP4_RS00035
uniprot id: A0A0G3ED11
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS09750
gene id: 1307763:L21SP4_RS09750
uniprot id: A0A0G3EK77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS02400
gene id: 1307763:L21SP4_RS02400
uniprot id: A0A0G3EEC1
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS09440
gene id: 1307763:L21SP4_RS09440
uniprot id: A0A0G3ELX1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1307763:L21SP4 RS01025
gene id: 1307763:L21SP4_RS01025
uniprot id: A0A0G3EDM2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1307763:L21SP4 RS08730
gene id: 1307763:L21SP4_RS08730
uniprot id: A0A0G3EJQ0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1307763:L21SP4 RS08005
gene id: 1307763:L21SP4_RS08005
uniprot id: A0A0G3EL71
names: Subcellular Location Annotation
messages: Nucleus

1307763:L21SP4 RS10775
gene id: 1307763:L21SP4_RS10775
uniprot id: A0A0G3EKY4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07955
gene id: 1307763:L21SP4_RS07955
uniprot id: A0A0G3EL63
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1307763:L21SP4 RS05690
gene id: 1307763:L21SP4_RS05690
uniprot id: A0A0G3EJV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1307763:L21SP4 RS08355
gene id: 1307763:L21SP4_RS08355
uniprot id: A0A0G3EHP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1307763:L21SP4 RS06980
gene id: 1307763:L21SP4_RS06980
uniprot id: A0A0G3EKH1
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08375
gene id: 1307763:L21SP4_RS08375
uniprot id: A0A0G3EEP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1307763:L21SP4 RS05180
gene id: 1307763:L21SP4_RS05180
uniprot id: A0A0G3EHN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1307763:L21SP4 RS07080
gene id: 1307763:L21SP4_RS07080
uniprot id: A0A0G3EKI8
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1307763:L21SP4 RS12505
gene id: 1307763:L21SP4_RS12505
uniprot id: A0A0G3EFU7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS08575
gene id: 1307763:L21SP4_RS08575
uniprot id: A0A0G3EF76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1307763:L21SP4 RS12620
gene id: 1307763:L21SP4_RS12620
uniprot id: A0A0G3EGM8
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1307763:L21SP4 RS07885
gene id: 1307763:L21SP4_RS07885
uniprot id: A0A0G3EL47
names: Similarity
messages: Belongs to the DtxR/MntR family.

1307763:L21SP4 RS08290
gene id: 1307763:L21SP4_RS08290
uniprot id: A0A0G3ELC9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1307763:L21SP4 RS11425
gene id: 1307763:L21SP4_RS11425
uniprot id: A0A0G3ELB5
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1307763:L21SP4 RS00565
gene id: 1307763:L21SP4_RS00565
uniprot id: A0A0G3EAC9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1307763:L21SP4 RS09045
gene id: 1307763:L21SP4_RS09045
uniprot id: A0A0G3EI20
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1307763:L21SP4 RS06710
gene id: 1307763:L21SP4_RS06710
uniprot id: A0A0G3EDU0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS04890
gene id: 1307763:L21SP4_RS04890
uniprot id: A0A0G3EHD8
names: Similarity
messages: Belongs to the peptidase S41A family.

1307763:L21SP4 RS02695
gene id: 1307763:L21SP4_RS02695
uniprot id: A0A0G3EBJ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1307763:L21SP4 RS05790
gene id: 1307763:L21SP4_RS05790
uniprot id: A0A0G3EJX9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1307763:L21SP4 RS09545
gene id: 1307763:L21SP4_RS09545
uniprot id: A0A0G3EK46
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1307763:L21SP4 RS00650
gene id: 1307763:L21SP4_RS00650
uniprot id: A0A0G3EH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1307763:L21SP4 RS05365
gene id: 1307763:L21SP4_RS05365
uniprot id: A0A0G3ED16
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1307763:L21SP4 RS13150
gene id: 1307763:L21SP4_RS13150
uniprot id: A0A0G3EKR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1307763:L21SP4 RS07435
gene id: 1307763:L21SP4_RS07435
uniprot id: A0A0G3EH69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1307763:L21SP4 RS06805
gene id: 1307763:L21SP4_RS06805
uniprot id: A0A0G3EIK0
names: Similarity
messages: Belongs to the MEMO1 family.

1307763:L21SP4 RS08285
gene id: 1307763:L21SP4_RS08285
uniprot id: A0A0G3EF22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1307763:L21SP4 RS05035
gene id: 1307763:L21SP4_RS05035
uniprot id: A0A0G3EHG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1307763:L21SP4 RS00920
gene id: 1307763:L21SP4_RS00920
uniprot id: A0A0G3EAJ3
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1307763:L21SP4 RS01480
gene id: 1307763:L21SP4_RS01480
uniprot id: A0A0G3EBB4
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06225
gene id: 1307763:L21SP4_RS06225
uniprot id: A0A0G3EDG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1307763:L21SP4 RS12215
gene id: 1307763:L21SP4_RS12215
uniprot id: A0A0G3EAV5
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1307763:L21SP4 RS02140
gene id: 1307763:L21SP4_RS02140
uniprot id: A0A0G3EFX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1307763:L21SP4 RS05000
gene id: 1307763:L21SP4_RS05000
uniprot id: A0A0G3ED77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307763:L21SP4 RS09240
gene id: 1307763:L21SP4_RS09240
uniprot id: A0A0G3EF90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS04065
gene id: 1307763:L21SP4_RS04065
uniprot id: A0A0G3EC65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00120
gene id: 1307763:L21SP4_RS00120
uniprot id: A0A0G3EAN3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1307763:L21SP4 RS02535
gene id: 1307763:L21SP4_RS02535
uniprot id: A0A0G3EHY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1307763:L21SP4 RS01940
gene id: 1307763:L21SP4_RS01940
uniprot id: A0A0G3EHK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1307763:L21SP4 RS10070
gene id: 1307763:L21SP4_RS10070
uniprot id: A0A0G3EMA1
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS00075
gene id: 1307763:L21SP4_RS00075
uniprot id: A0A0G3EEY5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1307763:L21SP4 RS08365
gene id: 1307763:L21SP4_RS08365
uniprot id: A0A0G3ELE3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1307763:L21SP4 RS07860
gene id: 1307763:L21SP4_RS07860
uniprot id: A0A0G3EL43
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1307763:L21SP4 RS06635
gene id: 1307763:L21SP4_RS06635
uniprot id: A0A0G3EIG3
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1307763:L21SP4 RS03790
gene id: 1307763:L21SP4_RS03790
uniprot id: A0A0G3ECL7
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07260
gene id: 1307763:L21SP4_RS07260
uniprot id: A0A0G3EE46
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS01315
gene id: 1307763:L21SP4_RS01315
uniprot id: A0A0G3EHB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS08660
gene id: 1307763:L21SP4_RS08660
uniprot id: A0A0G3EJN5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1307763:L21SP4 RS02395
gene id: 1307763:L21SP4_RS02395
uniprot id: A0A0G3EB94
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1307763:L21SP4 RS08675
gene id: 1307763:L21SP4_RS08675
uniprot id: A0A0G3ELJ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS02800
gene id: 1307763:L21SP4_RS02800
uniprot id: A0A0G3EBL4
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1307763:L21SP4 RS11900
gene id: 1307763:L21SP4_RS11900
uniprot id: A0A0G3EJN3
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1307763:L21SP4 RS08625
gene id: 1307763:L21SP4_RS08625
uniprot id: A0A0G3EF84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS01885
gene id: 1307763:L21SP4_RS01885
uniprot id: A0A0G3EBI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1307763:L21SP4 RS06965
gene id: 1307763:L21SP4_RS06965
uniprot id: A0A0G3EDY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1307763:L21SP4 RS00130
gene id: 1307763:L21SP4_RS00130
uniprot id: A0A0G3EEZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1307763:L21SP4 RS08950
gene id: 1307763:L21SP4_RS08950
uniprot id: A0A0G3EFE6
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1307763:L21SP4 RS11950
gene id: 1307763:L21SP4_RS11950
uniprot id: A0A0G3EJP3
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1307763:L21SP4 RS07935
gene id: 1307763:L21SP4_RS07935
uniprot id: A0A0G3EJA9
names: Similarity
messages: Belongs to the UPF0047 family.

1307763:L21SP4 RS11565
gene id: 1307763:L21SP4_RS11565
uniprot id: A0A0G3EN59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1307763:L21SP4 RS05555
gene id: 1307763:L21SP4_RS05555
uniprot id: A0A0G3EJT7
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS11465
gene id: 1307763:L21SP4_RS11465
uniprot id: A0A0G3EN40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1307763:L21SP4 RS04155
gene id: 1307763:L21SP4_RS04155
uniprot id: A0A0G3EIW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS08360
gene id: 1307763:L21SP4_RS08360
uniprot id: A0A0G3EF36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1307763:L21SP4 RS01225
gene id: 1307763:L21SP4_RS01225
uniprot id: A0A0G3EAM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1307763:L21SP4 RS07750
gene id: 1307763:L21SP4_RS07750
uniprot id: A0A0G3EHG2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1307763:L21SP4 RS00840
gene id: 1307763:L21SP4_RS00840
uniprot id: A0A0G3EAI2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1307763:L21SP4 RS06095
gene id: 1307763:L21SP4_RS06095
uniprot id: A0A0G3EK27
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1307763:L21SP4 RS03655
gene id: 1307763:L21SP4_RS03655
uniprot id: A0A0G3EIP1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1307763:L21SP4 RS10030
gene id: 1307763:L21SP4_RS10030
uniprot id: A0A0G3EFN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1307763:L21SP4 RS10740
gene id: 1307763:L21SP4_RS10740
uniprot id: A0A0G3EGF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

1307763:L21SP4 RS00135
gene id: 1307763:L21SP4_RS00135
uniprot id: A0A0G3EA49
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1307763:L21SP4 RS10600
gene id: 1307763:L21SP4_RS10600
uniprot id: A0A0G3EKV7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1307763:L21SP4 RS08020
gene id: 1307763:L21SP4_RS08020
uniprot id: A0A0G3EHJ5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1307763:L21SP4 RS05795
gene id: 1307763:L21SP4_RS05795
uniprot id: A0A0G3EI01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1307763:L21SP4 RS07625
gene id: 1307763:L21SP4_RS07625
uniprot id: A0A0G3EHE0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1307763:L21SP4 RS07160
gene id: 1307763:L21SP4_RS07160
uniprot id: A0A0G3EIQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1307763:L21SP4 RS03015
gene id: 1307763:L21SP4_RS03015
uniprot id: A0A0G3EIC1
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS11360
gene id: 1307763:L21SP4_RS11360
uniprot id: A0A0G3EN22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

1307763:L21SP4 RS00805
gene id: 1307763:L21SP4_RS00805
uniprot id: A0A0G3EH37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1307763:L21SP4 RS02175
gene id: 1307763:L21SP4_RS02175
uniprot id: A0A0G3EE79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1307763:L21SP4 RS02855
gene id: 1307763:L21SP4_RS02855
uniprot id: A0A0G3EBM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1307763:L21SP4 RS10155
gene id: 1307763:L21SP4_RS10155
uniprot id: A0A0G3EFW1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1307763:L21SP4 RS12075
gene id: 1307763:L21SP4_RS12075
uniprot id: A0A0G3EGT9
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1307763:L21SP4 RS04980
gene id: 1307763:L21SP4_RS04980
uniprot id: A0A0G3EJB6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1307763:L21SP4 RS09035
gene id: 1307763:L21SP4_RS09035
uniprot id: A0A0G3EJW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1307763:L21SP4 RS10420
gene id: 1307763:L21SP4_RS10420
uniprot id: A0A0G3EG00
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1307763:L21SP4 RS11960
gene id: 1307763:L21SP4_RS11960
uniprot id: A0A0G3ENE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307763:L21SP4 RS02940
gene id: 1307763:L21SP4_RS02940
uniprot id: A0A0G3EC61
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1307763:L21SP4 RS00505
gene id: 1307763:L21SP4_RS00505
uniprot id: A0A0G3EAU7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1307763:L21SP4 RS09210
gene id: 1307763:L21SP4_RS09210
uniprot id: A0A0G3EJZ7
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS09565
gene id: 1307763:L21SP4_RS09565
uniprot id: A0A0G3ELZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1307763:L21SP4 RS02520
gene id: 1307763:L21SP4_RS02520
uniprot id: A0A0G3EBB8
names: Similarity
messages: Belongs to the NAD synthetase family.

1307763:L21SP4 RS05670
gene id: 1307763:L21SP4_RS05670
uniprot id: A0A0G3EHX8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1307763:L21SP4 RS01175
gene id: 1307763:L21SP4_RS01175
uniprot id: A0A0G3EAM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1307763:L21SP4 RS05130
gene id: 1307763:L21SP4_RS05130
uniprot id: A0A0G3EG04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1307763:L21SP4 RS07105
gene id: 1307763:L21SP4_RS07105
uniprot id: A0A0G3EKJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1307763:L21SP4 RS08345
gene id: 1307763:L21SP4_RS08345
uniprot id: A0A0G3EJI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1307763:L21SP4 RS01505
gene id: 1307763:L21SP4_RS01505
uniprot id: A0A0G3EBB9
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1307763:L21SP4 RS05215
gene id: 1307763:L21SP4_RS05215
uniprot id: A0A0G3EG15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1307763:L21SP4 RS00425
gene id: 1307763:L21SP4_RS00425
uniprot id: A0A0G3EAT6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1307763:L21SP4 RS07135
gene id: 1307763:L21SP4_RS07135
uniprot id: A0A0G3EIQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1307763:L21SP4 RS11455
gene id: 1307763:L21SP4_RS11455
uniprot id: A0A0G3EJF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1307763:L21SP4 RS03700
gene id: 1307763:L21SP4_RS03700
uniprot id: A0A0G3ECK2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1307763:L21SP4 RS08390
gene id: 1307763:L21SP4_RS08390
uniprot id: A0A0G3ELE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1307763:L21SP4 RS05495
gene id: 1307763:L21SP4_RS05495
uniprot id: A0A0G3EJS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1307763:L21SP4 RS06930
gene id: 1307763:L21SP4_RS06930
uniprot id: A0A0G3EKG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1307763:L21SP4 RS03640
gene id: 1307763:L21SP4_RS03640
uniprot id: A0A0G3EBZ8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS02495
gene id: 1307763:L21SP4_RS02495
uniprot id: A0A0G3EBB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00770
gene id: 1307763:L21SP4_RS00770
uniprot id: A0A0G3EDI0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS10715
gene id: 1307763:L21SP4_RS10715
uniprot id: A0A0G3EJ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1307763:L21SP4 RS04035
gene id: 1307763:L21SP4_RS04035
uniprot id: A0A0G3EH04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane

1307763:L21SP4 RS10345
gene id: 1307763:L21SP4_RS10345
uniprot id: A0A0G3EG80
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1307763:L21SP4 RS09850
gene id: 1307763:L21SP4_RS09850
uniprot id: A0A0G3EFV0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1307763:L21SP4 RS01285
gene id: 1307763:L21SP4_RS01285
uniprot id: A0A0G3EB76
names: Similarity
messages: Belongs to the GSP E family.

1307763:L21SP4 RS07015
gene id: 1307763:L21SP4_RS07015
uniprot id: A0A0G3EDZ6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1307763:L21SP4 RS10355
gene id: 1307763:L21SP4_RS10355
uniprot id: A0A0G3EKR4
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS09200
gene id: 1307763:L21SP4_RS09200
uniprot id: A0A0G3EFI6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1307763:L21SP4 RS11385
gene id: 1307763:L21SP4_RS11385
uniprot id: A0A0G3EGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

1307763:L21SP4 RS02935
gene id: 1307763:L21SP4_RS02935
uniprot id: A0A0G3EER1
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.

1307763:L21SP4 RS03870
gene id: 1307763:L21SP4_RS03870
uniprot id: A0A0G3EGX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1307763:L21SP4 RS05780
gene id: 1307763:L21SP4_RS05780
uniprot id: A0A0G3EG98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1307763:L21SP4 RS03500
gene id: 1307763:L21SP4_RS03500
uniprot id: A0A0G3EEY9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1307763:L21SP4 RS08340
gene id: 1307763:L21SP4_RS08340
uniprot id: A0A0G3ELD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1307763:L21SP4 RS08405
gene id: 1307763:L21SP4_RS08405
uniprot id: A0A0G3EHQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1307763:L21SP4 RS09330
gene id: 1307763:L21SP4_RS09330
uniprot id: A0A0G3ELV0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00515
gene id: 1307763:L21SP4_RS00515
uniprot id: A0A0G3EF45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

1307763:L21SP4 RS12090
gene id: 1307763:L21SP4_RS12090
uniprot id: A0A0G3ENH2
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS00300
gene id: 1307763:L21SP4_RS00300
uniprot id: A0A0G3EDA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS03775
gene id: 1307763:L21SP4_RS03775
uniprot id: A0A0G3EGV4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1307763:L21SP4 RS09350
gene id: 1307763:L21SP4_RS09350
uniprot id: A0A0G3EI75
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS05915
gene id: 1307763:L21SP4_RS05915
uniprot id: A0A0G3EDP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1307763:L21SP4 RS02440
gene id: 1307763:L21SP4_RS02440
uniprot id: A0A0G3EG18
names: Similarity
messages: Belongs to the universal stress protein A family.

1307763:L21SP4 RS03080
gene id: 1307763:L21SP4_RS03080
uniprot id: A0A0G3EC83
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS05450
gene id: 1307763:L21SP4_RS05450
uniprot id: A0A0G3EJR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

1307763:L21SP4 RS05640
gene id: 1307763:L21SP4_RS05640
uniprot id: A0A0G3EJU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1307763:L21SP4 RS03530
gene id: 1307763:L21SP4_RS03530
uniprot id: A0A0G3ECG7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1307763:L21SP4 RS02325
gene id: 1307763:L21SP4_RS02325
uniprot id: A0A0G3EBR9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS03590
gene id: 1307763:L21SP4_RS03590
uniprot id: A0A0G3EBZ4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1307763:L21SP4 RS10665
gene id: 1307763:L21SP4_RS10665
uniprot id: A0A0G3EGD7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1307763:L21SP4 RS07045
gene id: 1307763:L21SP4_RS07045
uniprot id: A0A0G3EGY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1307763:L21SP4 RS07420
gene id: 1307763:L21SP4_RS07420
uniprot id: A0A0G3EKQ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307763:L21SP4 RS07635
gene id: 1307763:L21SP4_RS07635
uniprot id: A0A0G3EL04
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1307763:L21SP4 RS06515
gene id: 1307763:L21SP4_RS06515
uniprot id: A0A0G3EDQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1307763:L21SP4 RS02480
gene id: 1307763:L21SP4_RS02480
uniprot id: A0A0G3EBU8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

1307763:L21SP4 RS06885
gene id: 1307763:L21SP4_RS06885
uniprot id: A0A0G3EIL4
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1307763:L21SP4 RS07255
gene id: 1307763:L21SP4_RS07255
uniprot id: A0A0G3EIR8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS00150
gene id: 1307763:L21SP4_RS00150
uniprot id: A0A0G3EGS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1307763:L21SP4 RS08205
gene id: 1307763:L21SP4_RS08205
uniprot id: A0A0G3EF12
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1307763:L21SP4 RS08455
gene id: 1307763:L21SP4_RS08455
uniprot id: A0A0G3EHR7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1307763:L21SP4 RS07785
gene id: 1307763:L21SP4_RS07785
uniprot id: A0A0G3EL31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1307763:L21SP4 RS12140
gene id: 1307763:L21SP4_RS12140
uniprot id: A0A0G3EH67
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

1307763:L21SP4 RS02845
gene id: 1307763:L21SP4_RS02845
uniprot id: A0A0G3EI89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1307763:L21SP4 RS02320
gene id: 1307763:L21SP4_RS02320
uniprot id: A0A0G3EEA9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1307763:L21SP4 RS08305
gene id: 1307763:L21SP4_RS08305
uniprot id: A0A0G3EHN5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1307763:L21SP4 RS08935
gene id: 1307763:L21SP4_RS08935
uniprot id: A0A0G3EJU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1307763:L21SP4 RS10060
gene id: 1307763:L21SP4_RS10060
uniprot id: A0A0G3EIL7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1307763:L21SP4 RS08655
gene id: 1307763:L21SP4_RS08655
uniprot id: A0A0G3ELI6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1307763:L21SP4 RS06915
gene id: 1307763:L21SP4_RS06915
uniprot id: A0A0G3EDX5
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1307763:L21SP4 RS06385
gene id: 1307763:L21SP4_RS06385
uniprot id: A0A0G3EK66
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1307763:L21SP4 RS09540
gene id: 1307763:L21SP4_RS09540
uniprot id: A0A0G3ELZ2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1307763:L21SP4 RS05225
gene id: 1307763:L21SP4_RS05225
uniprot id: A0A0G3EJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GmhB family.
messages: Cytoplasm

1307763:L21SP4 RS08120
gene id: 1307763:L21SP4_RS08120
uniprot id: A0A0G3EHK7
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06920
gene id: 1307763:L21SP4_RS06920
uniprot id: A0A0G3EGW3
names: Subcellular Location Annotation
messages: Nucleus

1307763:L21SP4 RS08480
gene id: 1307763:L21SP4_RS08480
uniprot id: A0A0G3EER3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1307763:L21SP4 RS02570
gene id: 1307763:L21SP4_RS02570
uniprot id: A0A0G3EBC7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1307763:L21SP4 RS03715
gene id: 1307763:L21SP4_RS03715
uniprot id: A0A0G3EGU2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS04765
gene id: 1307763:L21SP4_RS04765
uniprot id: A0A0G3ECJ5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1307763:L21SP4 RS08380
gene id: 1307763:L21SP4_RS08380
uniprot id: A0A0G3EHQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1307763:L21SP4 RS05825
gene id: 1307763:L21SP4_RS05825
uniprot id: A0A0G3EI05
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

1307763:L21SP4 RS08695
gene id: 1307763:L21SP4_RS08695
uniprot id: A0A0G3EFA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS11295
gene id: 1307763:L21SP4_RS11295
uniprot id: A0A0G3EL89
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06630
gene id: 1307763:L21SP4_RS06630
uniprot id: A0A0G3EKA7
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS00985
gene id: 1307763:L21SP4_RS00985
uniprot id: A0A0G3EH68
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS01445
gene id: 1307763:L21SP4_RS01445
uniprot id: A0A0G3EFK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1307763:L21SP4 RS07100
gene id: 1307763:L21SP4_RS07100
uniprot id: A0A0G3EED9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1307763:L21SP4 RS03830
gene id: 1307763:L21SP4_RS03830
uniprot id: A0A0G3EF44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1307763:L21SP4 RS09975
gene id: 1307763:L21SP4_RS09975
uniprot id: A0A0G3EFM4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1307763:L21SP4 RS03470
gene id: 1307763:L21SP4_RS03470
uniprot id: A0A0G3EGP6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1307763:L21SP4 RS10125
gene id: 1307763:L21SP4_RS10125
uniprot id: A0A0G3EKF0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS05310
gene id: 1307763:L21SP4_RS05310
uniprot id: A0A0G3EHR6
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1307763:L21SP4 RS12280
gene id: 1307763:L21SP4_RS12280
uniprot id: A0A0G3EGL5
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS06755
gene id: 1307763:L21SP4_RS06755
uniprot id: A0A0G3EII9
names: Similarity
messages: Belongs to the DEAD box helicase family.

1307763:L21SP4 RS01700
gene id: 1307763:L21SP4_RS01700
uniprot id: A0A0G3EDY4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1307763:L21SP4 RS05675
gene id: 1307763:L21SP4_RS05675
uniprot id: A0A0G3ED60
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS06795
gene id: 1307763:L21SP4_RS06795
uniprot id: A0A0G3EE92
names: Similarity
messages: Belongs to the P(II) protein family.

1307763:L21SP4 RS03540
gene id: 1307763:L21SP4_RS03540
uniprot id: A0A0G3EGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

1307763:L21SP4 RS00830
gene id: 1307763:L21SP4_RS00830
uniprot id: A0A0G3EH42
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1307763:L21SP4 RS05185
gene id: 1307763:L21SP4_RS05185
uniprot id: A0A0G3ECY4
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1307763:L21SP4 RS10855
gene id: 1307763:L21SP4_RS10855
uniprot id: A0A0G3EJ32
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1307763:L21SP4 RS09375
gene id: 1307763:L21SP4_RS09375
uniprot id: A0A0G3EFB8
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1307763:L21SP4 RS07285
gene id: 1307763:L21SP4_RS07285
uniprot id: A0A0G3EE51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1307763:L21SP4 RS11350
gene id: 1307763:L21SP4_RS11350
uniprot id: A0A0G3EJC9
names: Caution
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS09500
gene id: 1307763:L21SP4_RS09500
uniprot id: A0A0G3EFE2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1307763:L21SP4 RS11450
gene id: 1307763:L21SP4_RS11450
uniprot id: A0A0G3EGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS04750
gene id: 1307763:L21SP4_RS04750
uniprot id: A0A0G3ED34
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307763:L21SP4 RS01930
gene id: 1307763:L21SP4_RS01930
uniprot id: A0A0G3EE29
names: Similarity
messages: Belongs to the UPF0047 family.

1307763:L21SP4 RS04150
gene id: 1307763:L21SP4_RS04150
uniprot id: A0A0G3ECS7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1307763:L21SP4 RS00530
gene id: 1307763:L21SP4_RS00530
uniprot id: A0A0G3EAV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1307763:L21SP4 RS09895
gene id: 1307763:L21SP4_RS09895
uniprot id: A0A0G3EFK8
names: Similarity
messages: Belongs to the GcvT family.

1307763:L21SP4 RS09890
gene id: 1307763:L21SP4_RS09890
uniprot id: A0A0G3EKA6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1307763:L21SP4 RS04435
gene id: 1307763:L21SP4_RS04435
uniprot id: A0A0G3EH77
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS11020
gene id: 1307763:L21SP4_RS11020
uniprot id: A0A0G3EL33
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1307763:L21SP4 RS02420
gene id: 1307763:L21SP4_RS02420
uniprot id: A0A0G3EBA0
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1307763:L21SP4 RS10405
gene id: 1307763:L21SP4_RS10405
uniprot id: A0A0G3EG88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1307763:L21SP4 RS06910
gene id: 1307763:L21SP4_RS06910
uniprot id: A0A0G3EIM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1307763:L21SP4 RS09600
gene id: 1307763:L21SP4_RS09600
uniprot id: A0A0G3EFF8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1307763:L21SP4 RS07925
gene id: 1307763:L21SP4_RS07925
uniprot id: A0A0G3EEX4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1307763:L21SP4 RS05295
gene id: 1307763:L21SP4_RS05295
uniprot id: A0A0G3EJN2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS07430
gene id: 1307763:L21SP4_RS07430
uniprot id: A0A0G3EE81
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1307763:L21SP4 RS10235
gene id: 1307763:L21SP4_RS10235
uniprot id: A0A0G3EFX4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1307763:L21SP4 RS08885
gene id: 1307763:L21SP4_RS08885
uniprot id: A0A0G3EJT2
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1307763:L21SP4 RS06835
gene id: 1307763:L21SP4_RS06835
uniprot id: A0A0G3EDW0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1307763:L21SP4 RS07675
gene id: 1307763:L21SP4_RS07675
uniprot id: A0A0G3EHF1
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS07150
gene id: 1307763:L21SP4_RS07150
uniprot id: A0A0G3EEE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1307763:L21SP4 RS00010
gene id: 1307763:L21SP4_RS00010
uniprot id: A0A0G3EAH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1307763:L21SP4 RS08230
gene id: 1307763:L21SP4_RS08230
uniprot id: A0A0G3EF16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00825
gene id: 1307763:L21SP4_RS00825
uniprot id: A0A0G3EB02
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1307763:L21SP4 RS02130
gene id: 1307763:L21SP4_RS02130
uniprot id: A0A0G3EBM3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1307763:L21SP4 RS03560
gene id: 1307763:L21SP4_RS03560
uniprot id: A0A0G3EIM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

1307763:L21SP4 RS11845
gene id: 1307763:L21SP4_RS11845
uniprot id: A0A0G3EGP2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

1307763:L21SP4 RS04790
gene id: 1307763:L21SP4_RS04790
uniprot id: A0A0G3ECK1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1307763:L21SP4 RS08620
gene id: 1307763:L21SP4_RS08620
uniprot id: A0A0G3EHU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1307763:L21SP4 RS10280
gene id: 1307763:L21SP4_RS10280
uniprot id: A0A0G3EKP7
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1307763:L21SP4 RS04355
gene id: 1307763:L21SP4_RS04355
uniprot id: A0A0G3EIZ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS01925
gene id: 1307763:L21SP4_RS01925
uniprot id: A0A0G3EB08
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS09970
gene id: 1307763:L21SP4_RS09970
uniprot id: A0A0G3EKC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1307763:L21SP4 RS00520
gene id: 1307763:L21SP4_RS00520
uniprot id: A0A0G3EAB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1307763:L21SP4 RS08035
gene id: 1307763:L21SP4_RS08035
uniprot id: A0A0G3EJC8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1307763:L21SP4 RS10800
gene id: 1307763:L21SP4_RS10800
uniprot id: A0A0G3EKY9
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1307763:L21SP4 RS05755
gene id: 1307763:L21SP4_RS05755
uniprot id: A0A0G3EG93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1307763:L21SP4 RS09070
gene id: 1307763:L21SP4_RS09070
uniprot id: A0A0G3EFG4
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1307763:L21SP4 RS08435
gene id: 1307763:L21SP4_RS08435
uniprot id: A0A0G3EF51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1307763:L21SP4 RS08720
gene id: 1307763:L21SP4_RS08720
uniprot id: A0A0G3EFA5
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08635
gene id: 1307763:L21SP4_RS08635
uniprot id: A0A0G3EJN0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS06165
gene id: 1307763:L21SP4_RS06165
uniprot id: A0A0G3EK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1307763:L21SP4 RS02610
gene id: 1307763:L21SP4_RS02610
uniprot id: A0A0G3EI48
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1307763:L21SP4 RS05145
gene id: 1307763:L21SP4_RS05145
uniprot id: A0A0G3EHN3
names: Similarity
messages: Belongs to the acylphosphatase family.

1307763:L21SP4 RS11355
gene id: 1307763:L21SP4_RS11355
uniprot id: A0A0G3EGR2
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS08785
gene id: 1307763:L21SP4_RS08785
uniprot id: A0A0G3EHX9
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS02790
gene id: 1307763:L21SP4_RS02790
uniprot id: A0A0G3EI79
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1307763:L21SP4 RS08235
gene id: 1307763:L21SP4_RS08235
uniprot id: A0A0G3ELB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS02700
gene id: 1307763:L21SP4_RS02700
uniprot id: A0A0G3EEN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1307763:L21SP4 RS08475
gene id: 1307763:L21SP4_RS08475
uniprot id: A0A0G3EJJ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1307763:L21SP4 RS02905
gene id: 1307763:L21SP4_RS02905
uniprot id: A0A0G3EBN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1307763:L21SP4 RS09060
gene id: 1307763:L21SP4_RS09060
uniprot id: A0A0G3EF52
names: Similarity
messages: Belongs to the GARS family.

1307763:L21SP4 RS12635
gene id: 1307763:L21SP4_RS12635
uniprot id: A0A0G3EH54
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1307763:L21SP4 RS02370
gene id: 1307763:L21SP4_RS02370
uniprot id: A0A0G3EB89
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1307763:L21SP4 RS07700
gene id: 1307763:L21SP4_RS07700
uniprot id: A0A0G3EHF5
names: Similarity
messages: Belongs to the Fur family.

1307763:L21SP4 RS01395
gene id: 1307763:L21SP4_RS01395
uniprot id: A0A0G3EFI9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1307763:L21SP4 RS04085
gene id: 1307763:L21SP4_RS04085
uniprot id: A0A0G3EH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS07265
gene id: 1307763:L21SP4_RS07265
uniprot id: A0A0G3EH36
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS06010
gene id: 1307763:L21SP4_RS06010
uniprot id: A0A0G3EI33
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS08085
gene id: 1307763:L21SP4_RS08085
uniprot id: A0A0G3EJD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1307763:L21SP4 RS10085
gene id: 1307763:L21SP4_RS10085
uniprot id: A0A0G3EIM3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS05385
gene id: 1307763:L21SP4_RS05385
uniprot id: A0A0G3EHS9
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1307763:L21SP4 RS05715
gene id: 1307763:L21SP4_RS05715
uniprot id: A0A0G3EJW3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1307763:L21SP4 RS05010
gene id: 1307763:L21SP4_RS05010
uniprot id: A0A0G3EHG3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1307763:L21SP4 RS09390
gene id: 1307763:L21SP4_RS09390
uniprot id: A0A0G3ELW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1307763:L21SP4 RS08300
gene id: 1307763:L21SP4_RS08300
uniprot id: A0A0G3EEN6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1307763:L21SP4 RS02010
gene id: 1307763:L21SP4_RS02010
uniprot id: A0A0G3EHL6
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS08770
gene id: 1307763:L21SP4_RS08770
uniprot id: A0A0G3ELK8
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1307763:L21SP4 RS01690
gene id: 1307763:L21SP4_RS01690
uniprot id: A0A0G3EFP8
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

1307763:L21SP4 RS05055
gene id: 1307763:L21SP4_RS05055
uniprot id: A0A0G3EJD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1307763:L21SP4 RS09925
gene id: 1307763:L21SP4_RS09925
uniprot id: A0A0G3EIJ1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1307763:L21SP4 RS10670
gene id: 1307763:L21SP4_RS10670
uniprot id: A0A0G3EMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1307763:L21SP4 RS07985
gene id: 1307763:L21SP4_RS07985
uniprot id: A0A0G3EJB7
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS07145
gene id: 1307763:L21SP4_RS07145
uniprot id: A0A0G3EH10
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1307763:L21SP4 RS08075
gene id: 1307763:L21SP4_RS08075
uniprot id: A0A0G3EEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1307763:L21SP4 RS04080
gene id: 1307763:L21SP4_RS04080
uniprot id: A0A0G3EIV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1307763:L21SP4 RS01650
gene id: 1307763:L21SP4_RS01650
uniprot id: A0A0G3EDX6
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1307763:L21SP4 RS06895
gene id: 1307763:L21SP4_RS06895
uniprot id: A0A0G3EGV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1307763:L21SP4 RS07365
gene id: 1307763:L21SP4_RS07365
uniprot id: A0A0G3EH56
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1307763:L21SP4 RS10955
gene id: 1307763:L21SP4_RS10955
uniprot id: A0A0G3EJ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS09860
gene id: 1307763:L21SP4_RS09860
uniprot id: A0A0G3EM53
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

1307763:L21SP4 RS00665
gene id: 1307763:L21SP4_RS00665
uniprot id: A0A0G3EAF5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS10565
gene id: 1307763:L21SP4_RS10565
uniprot id: A0A0G3EMQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307763:L21SP4 RS01500
gene id: 1307763:L21SP4_RS01500
uniprot id: A0A0G3EDU5
names: Similarity
messages: Belongs to the thioredoxin family.

1307763:L21SP4 RS04735
gene id: 1307763:L21SP4_RS04735
uniprot id: A0A0G3EHB5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1307763:L21SP4 RS09065
gene id: 1307763:L21SP4_RS09065
uniprot id: A0A0G3EI25
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1307763:L21SP4 RS02500
gene id: 1307763:L21SP4_RS02500
uniprot id: A0A0G3EED3
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1307763:L21SP4 RS09910
gene id: 1307763:L21SP4_RS09910
uniprot id: A0A0G3EM66
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

1307763:L21SP4 RS10090
gene id: 1307763:L21SP4_RS10090
uniprot id: A0A0G3EFY7
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1307763:L21SP4 RS07065
gene id: 1307763:L21SP4_RS07065
uniprot id: A0A0G3EE05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1307763:L21SP4 RS07290
gene id: 1307763:L21SP4_RS07290
uniprot id: A0A0G3EH40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1307763:L21SP4 RS04360
gene id: 1307763:L21SP4_RS04360
uniprot id: A0A0G3EH65
names: Similarity
messages: Belongs to the DprA/Smf family.

1307763:L21SP4 RS02560
gene id: 1307763:L21SP4_RS02560
uniprot id: A0A0G3EHY5
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS01125
gene id: 1307763:L21SP4_RS01125
uniprot id: A0A0G3EDN6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1307763:L21SP4 RS02035
gene id: 1307763:L21SP4_RS02035
uniprot id: A0A0G3EHM0
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

1307763:L21SP4 RS00700
gene id: 1307763:L21SP4_RS00700
uniprot id: A0A0G3EH18
names: Similarity
messages: Belongs to the XFP family.

1307763:L21SP4 RS12600
gene id: 1307763:L21SP4_RS12600
uniprot id: A0A0G3EFV0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1307763:L21SP4 RS04140
gene id: 1307763:L21SP4_RS04140
uniprot id: A0A0G3EC77
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS06830
gene id: 1307763:L21SP4_RS06830
uniprot id: A0A0G3EIK4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1307763:L21SP4 RS07790
gene id: 1307763:L21SP4_RS07790
uniprot id: A0A0G3EJ82
names: Similarity
messages: Belongs to the GSP E family.

1307763:L21SP4 RS02385
gene id: 1307763:L21SP4_RS02385
uniprot id: A0A0G3EHU9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1307763:L21SP4 RS02065
gene id: 1307763:L21SP4_RS02065
uniprot id: A0A0G3EFV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Homodimer.
messages: Monomer.
messages: Secreted

1307763:L21SP4 RS05930
gene id: 1307763:L21SP4_RS05930
uniprot id: A0A0G3EI22
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1307763:L21SP4 RS10455
gene id: 1307763:L21SP4_RS10455
uniprot id: A0A0G3EMN2
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1307763:L21SP4 RS01160
gene id: 1307763:L21SP4_RS01160
uniprot id: A0A0G3EB50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1307763:L21SP4 RS01980
gene id: 1307763:L21SP4_RS01980
uniprot id: A0A0G3EBJ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1307763:L21SP4 RS01005
gene id: 1307763:L21SP4_RS01005
uniprot id: A0A0G3EB23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1307763:L21SP4 RS00005
gene id: 1307763:L21SP4_RS00005
uniprot id: A0A0G3ED07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1307763:L21SP4 RS10765
gene id: 1307763:L21SP4_RS10765
uniprot id: A0A0G3EGF6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS08000
gene id: 1307763:L21SP4_RS08000
uniprot id: A0A0G3EEY4
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1307763:L21SP4 RS11965
gene id: 1307763:L21SP4_RS11965
uniprot id: A0A0G3ELK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307763:L21SP4 RS11475
gene id: 1307763:L21SP4_RS11475
uniprot id: A0A0G3EGH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1307763:L21SP4 RS02150
gene id: 1307763:L21SP4_RS02150
uniprot id: A0A0G3EE73
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1307763:L21SP4 RS01165
gene id: 1307763:L21SP4_RS01165
uniprot id: A0A0G3EH94
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1307763:L21SP4 RS01170
gene id: 1307763:L21SP4_RS01170
uniprot id: A0A0G3EFF5
names: Similarity
messages: Belongs to the fabD family.

1307763:L21SP4 RS08105
gene id: 1307763:L21SP4_RS08105
uniprot id: A0A0G3EL91
names: Similarity
messages: Belongs to the peptidase S24 family.

1307763:L21SP4 RS00740
gene id: 1307763:L21SP4_RS00740
uniprot id: A0A0G3EAG7
names: Similarity
messages: Belongs to the MlaA family.

1307763:L21SP4 RS07245
gene id: 1307763:L21SP4_RS07245
uniprot id: A0A0G3EH28
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1307763:L21SP4 RS11555
gene id: 1307763:L21SP4_RS11555
uniprot id: A0A0G3EJG8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1307763:L21SP4 RS00540
gene id: 1307763:L21SP4_RS00540
uniprot id: A0A0G3EF50
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1307763:L21SP4 RS00730
gene id: 1307763:L21SP4_RS00730
uniprot id: A0A0G3EF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1307763:L21SP4 RS05150
gene id: 1307763:L21SP4_RS05150
uniprot id: A0A0G3ECX1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1307763:L21SP4 RS08310
gene id: 1307763:L21SP4_RS08310
uniprot id: A0A0G3EF27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1307763:L21SP4 RS04835
gene id: 1307763:L21SP4_RS04835
uniprot id: A0A0G3EJ83
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1307763:L21SP4 RS05085
gene id: 1307763:L21SP4_RS05085
uniprot id: A0A0G3EJE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1307763:L21SP4 RS05165
gene id: 1307763:L21SP4_RS05165
uniprot id: A0A0G3EDE9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1307763:L21SP4 RS07180
gene id: 1307763:L21SP4_RS07180
uniprot id: A0A0G3EKK7
names: Caution
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS10520
gene id: 1307763:L21SP4_RS10520
uniprot id: A0A0G3EG13
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS01295
gene id: 1307763:L21SP4_RS01295
uniprot id: A0A0G3EFH4
names: Similarity
messages: Belongs to the GSP E family.

1307763:L21SP4 RS11480
gene id: 1307763:L21SP4_RS11480
uniprot id: A0A0G3EJF5
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1307763:L21SP4 RS10900
gene id: 1307763:L21SP4_RS10900
uniprot id: A0A0G3EG67
names: Similarity
messages: Belongs to the bacterial secretin family.

1307763:L21SP4 RS00395
gene id: 1307763:L21SP4_RS00395
uniprot id: A0A0G3EDC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS06640
gene id: 1307763:L21SP4_RS06640
uniprot id: A0A0G3EDS7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1307763:L21SP4 RS01045
gene id: 1307763:L21SP4_RS01045
uniprot id: A0A0G3EAK7
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

1307763:L21SP4 RS05705
gene id: 1307763:L21SP4_RS05705
uniprot id: A0A0G3EG85
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS02635
gene id: 1307763:L21SP4_RS02635
uniprot id: A0A0G3EI53
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.

1307763:L21SP4 RS05420
gene id: 1307763:L21SP4_RS05420
uniprot id: A0A0G3EDH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307763:L21SP4 RS08370
gene id: 1307763:L21SP4_RS08370
uniprot id: A0A0G3EJI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1307763:L21SP4 RS07730
gene id: 1307763:L21SP4_RS07730
uniprot id: A0A0G3EEU3
names: Subcellular Location Annotation
messages: Membrane

1307763:L21SP4 RS02745
gene id: 1307763:L21SP4_RS02745
uniprot id: A0A0G3EGC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1307763:L21SP4 RS05280
gene id: 1307763:L21SP4_RS05280
uniprot id: A0A0G3EJM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1307763:L21SP4 RS09310
gene id: 1307763:L21SP4_RS09310
uniprot id: A0A0G3EK17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307763:L21SP4 RS00330
gene id: 1307763:L21SP4_RS00330
uniprot id: A0A0G3EAS0
names: Similarity
messages: Belongs to the ribF family.

1307763:L21SP4 RS04520
gene id: 1307763:L21SP4_RS04520
uniprot id: A0A0G3EFK5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1307763:L21SP4 RS02145
gene id: 1307763:L21SP4_RS02145
uniprot id: A0A0G3EB40
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1307763:L21SP4 RS07070
gene id: 1307763:L21SP4_RS07070
uniprot id: A0A0G3EGZ3
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1307763:L21SP4 RS07090
gene id: 1307763:L21SP4_RS07090
uniprot id: A0A0G3EE10
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1307763:L21SP4 RS05940
gene id: 1307763:L21SP4_RS05940
uniprot id: A0A0G3EGC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1307763:L21SP4 RS02095
gene id: 1307763:L21SP4_RS02095
uniprot id: A0A0G3EB31
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.