1307761:L21SP2 RS10910
gene id: 1307761:L21SP2_RS10910
uniprot id: V5WIL0
names: Similarity
messages: Belongs to the UPF0251 family.

1307761:L21SP2 RS16080
gene id: 1307761:L21SP2_RS16080
uniprot id: V5WM90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS06385
gene id: 1307761:L21SP2_RS06385
uniprot id: V5WGS1
names: Similarity
messages: Belongs to the GARS family.

1307761:L21SP2 RS12810
gene id: 1307761:L21SP2_RS12810
uniprot id: V5WKJ7
names: Similarity
messages: Belongs to the SufE family.

1307761:L21SP2 RS02150
gene id: 1307761:L21SP2_RS02150
uniprot id: V5WE79
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1307761:L21SP2 RS07145
gene id: 1307761:L21SP2_RS07145
uniprot id: V5WGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1307761:L21SP2 RS06360
gene id: 1307761:L21SP2_RS06360
uniprot id: V5WGR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1307761:L21SP2 RS02445
gene id: 1307761:L21SP2_RS02445
uniprot id: V5WDQ8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1307761:L21SP2 RS00150
gene id: 1307761:L21SP2_RS00150
uniprot id: V5WCG6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS13145
gene id: 1307761:L21SP2_RS13145
uniprot id: V5WK56
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1307761:L21SP2 RS05850
gene id: 1307761:L21SP2_RS05850
uniprot id: V5WHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1307761:L21SP2 RS04115
gene id: 1307761:L21SP2_RS04115
uniprot id: V5WFG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1307761:L21SP2 RS15955
gene id: 1307761:L21SP2_RS15955
uniprot id: V5WLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS11485
gene id: 1307761:L21SP2_RS11485
uniprot id: V5WKR6
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1307761:L21SP2 RS04375
gene id: 1307761:L21SP2_RS04375
uniprot id: V5WGS0
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1307761:L21SP2 RS07210
gene id: 1307761:L21SP2_RS07210
uniprot id: V5WH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS08760
gene id: 1307761:L21SP2_RS08760
uniprot id: V5WI54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1307761:L21SP2 RS11835
gene id: 1307761:L21SP2_RS11835
uniprot id: V5WJ43
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1307761:L21SP2 RS00295
gene id: 1307761:L21SP2_RS00295
uniprot id: V5WCK5
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1307761:L21SP2 RS09755
gene id: 1307761:L21SP2_RS09755
uniprot id: V5WIN2
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

1307761:L21SP2 RS16405
gene id: 1307761:L21SP2_RS16405
uniprot id: V5WME8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1307761:L21SP2 RS08790
gene id: 1307761:L21SP2_RS08790
uniprot id: V5WI59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1307761:L21SP2 RS14105
gene id: 1307761:L21SP2_RS14105
uniprot id: V5WL22
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1307761:L21SP2 RS05910
gene id: 1307761:L21SP2_RS05910
uniprot id: V5WFU7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1307761:L21SP2 RS15545
gene id: 1307761:L21SP2_RS15545
uniprot id: V5WNP2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307761:L21SP2 RS07345
gene id: 1307761:L21SP2_RS07345
uniprot id: V5WGJ3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS03520
gene id: 1307761:L21SP2_RS03520
uniprot id: V5WEE0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS15795
gene id: 1307761:L21SP2_RS15795
uniprot id: V5WNA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1307761:L21SP2 RS08835
gene id: 1307761:L21SP2_RS08835
uniprot id: V5WHF4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1307761:L21SP2 RS06165
gene id: 1307761:L21SP2_RS06165
uniprot id: V5WFV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1307761:L21SP2 RS18710
gene id: 1307761:L21SP2_RS18710
uniprot id: V5WEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1307761:L21SP2 RS15280
gene id: 1307761:L21SP2_RS15280
uniprot id: V5WL97
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS12030
gene id: 1307761:L21SP2_RS12030
uniprot id: V5WJR7
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05985
gene id: 1307761:L21SP2_RS05985
uniprot id: V5WGK1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1307761:L21SP2 RS03970
gene id: 1307761:L21SP2_RS03970
uniprot id: V5WEN2
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1307761:L21SP2 RS08225
gene id: 1307761:L21SP2_RS08225
uniprot id: V5WH25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1307761:L21SP2 RS04095
gene id: 1307761:L21SP2_RS04095
uniprot id: V5WF85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1307761:L21SP2 RS00595
gene id: 1307761:L21SP2_RS00595
uniprot id: V5WEI5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1307761:L21SP2 RS08275
gene id: 1307761:L21SP2_RS08275
uniprot id: V5WH66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

1307761:L21SP2 RS08720
gene id: 1307761:L21SP2_RS08720
uniprot id: V5WJ76
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1307761:L21SP2 RS08360
gene id: 1307761:L21SP2_RS08360
uniprot id: V5WH48
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1307761:L21SP2 RS09750
gene id: 1307761:L21SP2_RS09750
uniprot id: V5WI02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1307761:L21SP2 RS08915
gene id: 1307761:L21SP2_RS08915
uniprot id: V5WI14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1307761:L21SP2 RS10495
gene id: 1307761:L21SP2_RS10495
uniprot id: V5WIH9
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS09380
gene id: 1307761:L21SP2_RS09380
uniprot id: V5WHP1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1307761:L21SP2 RS07225
gene id: 1307761:L21SP2_RS07225
uniprot id: V5WGG4
names: Similarity
messages: Belongs to the peptidase C56 family.

1307761:L21SP2 RS18870
gene id: 1307761:L21SP2_RS18870
uniprot id: V5WHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1307761:L21SP2 RS02225
gene id: 1307761:L21SP2_RS02225
uniprot id: V5WE29
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

1307761:L21SP2 RS00380
gene id: 1307761:L21SP2_RS00380
uniprot id: V5WD67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1307761:L21SP2 RS04020
gene id: 1307761:L21SP2_RS04020
uniprot id: V5WEP1
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1307761:L21SP2 RS05630
gene id: 1307761:L21SP2_RS05630
uniprot id: V5WFP8
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

1307761:L21SP2 RS15390
gene id: 1307761:L21SP2_RS15390
uniprot id: V5WN50
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

1307761:L21SP2 RS06910
gene id: 1307761:L21SP2_RS06910
uniprot id: V5WGV3
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS13160
gene id: 1307761:L21SP2_RS13160
uniprot id: V5WKS2
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS07440
gene id: 1307761:L21SP2_RS07440
uniprot id: V5WGL7
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS00320
gene id: 1307761:L21SP2_RS00320
uniprot id: V5WCK6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1307761:L21SP2 RS02935
gene id: 1307761:L21SP2_RS02935
uniprot id: V5WE45
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1307761:L21SP2 RS00675
gene id: 1307761:L21SP2_RS00675
uniprot id: V5WDB2
names: Similarity
messages: Belongs to the peptidase S16 family.

1307761:L21SP2 RS09235
gene id: 1307761:L21SP2_RS09235
uniprot id: V5WHK7
names: Similarity
messages: Belongs to the thymidine kinase family.

1307761:L21SP2 RS10160
gene id: 1307761:L21SP2_RS10160
uniprot id: V5WIB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS08695
gene id: 1307761:L21SP2_RS08695
uniprot id: V5WHA5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1307761:L21SP2 RS13830
gene id: 1307761:L21SP2_RS13830
uniprot id: V5WKD1
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1307761:L21SP2 RS00465
gene id: 1307761:L21SP2_RS00465
uniprot id: V5WEG1
names: Similarity
messages: Belongs to the GSP E family.

1307761:L21SP2 RS08150
gene id: 1307761:L21SP2_RS08150
uniprot id: V5WH46
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1307761:L21SP2 RS11155
gene id: 1307761:L21SP2_RS11155
uniprot id: V5WIT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1307761:L21SP2 RS01830
gene id: 1307761:L21SP2_RS01830
uniprot id: V5WE07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1307761:L21SP2 RS01990
gene id: 1307761:L21SP2_RS01990
uniprot id: V5WF91
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1307761:L21SP2 RS12105
gene id: 1307761:L21SP2_RS12105
uniprot id: V5WJT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS11900
gene id: 1307761:L21SP2_RS11900
uniprot id: V5WJ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS14835
gene id: 1307761:L21SP2_RS14835
uniprot id: V5WKZ5
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS15550
gene id: 1307761:L21SP2_RS15550
uniprot id: V5WLX9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307761:L21SP2 RS10290
gene id: 1307761:L21SP2_RS10290
uniprot id: V5WJ29
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1307761:L21SP2 RS16500
gene id: 1307761:L21SP2_RS16500
uniprot id: V5WNU9
names: Similarity
messages: Belongs to the IMPACT family.

1307761:L21SP2 RS15070
gene id: 1307761:L21SP2_RS15070
uniprot id: V5WLQ9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1307761:L21SP2 RS02755
gene id: 1307761:L21SP2_RS02755
uniprot id: V5WEH4
names: Similarity
messages: Belongs to the UPF0751 family.

1307761:L21SP2 RS16330
gene id: 1307761:L21SP2_RS16330
uniprot id: V5WMC5
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1307761:L21SP2 RS08515
gene id: 1307761:L21SP2_RS08515
uniprot id: V5WHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1307761:L21SP2 RS02120
gene id: 1307761:L21SP2_RS02120
uniprot id: V5WDH8
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

1307761:L21SP2 RS00370
gene id: 1307761:L21SP2_RS00370
uniprot id: V5WCL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1307761:L21SP2 RS16455
gene id: 1307761:L21SP2_RS16455
uniprot id: V5WMF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1307761:L21SP2 RS01550
gene id: 1307761:L21SP2_RS01550
uniprot id: V5WF12
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS13255
gene id: 1307761:L21SP2_RS13255
uniprot id: V5WKJ1
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1307761:L21SP2 RS05770
gene id: 1307761:L21SP2_RS05770
uniprot id: V5WFP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1307761:L21SP2 RS10235
gene id: 1307761:L21SP2_RS10235
uniprot id: V5WK32
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1307761:L21SP2 RS04085
gene id: 1307761:L21SP2_RS04085
uniprot id: V5WEQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1307761:L21SP2 RS06835
gene id: 1307761:L21SP2_RS06835
uniprot id: V5WH16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1307761:L21SP2 RS11855
gene id: 1307761:L21SP2_RS11855
uniprot id: V5WKZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1307761:L21SP2 RS04860
gene id: 1307761:L21SP2_RS04860
uniprot id: V5WH08
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

1307761:L21SP2 RS10365
gene id: 1307761:L21SP2_RS10365
uniprot id: V5WIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS05815
gene id: 1307761:L21SP2_RS05815
uniprot id: V5WFT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

1307761:L21SP2 RS03615
gene id: 1307761:L21SP2_RS03615
uniprot id: V5WEF8
names: Similarity
messages: Belongs to the hemerythrin family.

1307761:L21SP2 RS15995
gene id: 1307761:L21SP2_RS15995
uniprot id: V5WM92
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1307761:L21SP2 RS01910
gene id: 1307761:L21SP2_RS01910
uniprot id: V5WDC5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

1307761:L21SP2 RS00310
gene id: 1307761:L21SP2_RS00310
uniprot id: V5WEE3
names: Similarity
messages: Belongs to the UPF0145 family.

1307761:L21SP2 RS12080
gene id: 1307761:L21SP2_RS12080
uniprot id: V5WJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS00960
gene id: 1307761:L21SP2_RS00960
uniprot id: V5WEP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1307761:L21SP2 RS05260
gene id: 1307761:L21SP2_RS05260
uniprot id: V5WG66
names: Similarity
messages: Belongs to the DapB family.

1307761:L21SP2 RS07010
gene id: 1307761:L21SP2_RS07010
uniprot id: V5WH51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

1307761:L21SP2 RS06390
gene id: 1307761:L21SP2_RS06390
uniprot id: V5WGK8
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1307761:L21SP2 RS11825
gene id: 1307761:L21SP2_RS11825
uniprot id: V5WJN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1307761:L21SP2 RS09250
gene id: 1307761:L21SP2_RS09250
uniprot id: V5WI65
names: Similarity
messages: Belongs to the peptidase M18 family.

1307761:L21SP2 RS05840
gene id: 1307761:L21SP2_RS05840
uniprot id: V5WGH3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1307761:L21SP2 RS10060
gene id: 1307761:L21SP2_RS10060
uniprot id: V5WI37
names: Similarity
messages: Belongs to the peptidase M16 family.

1307761:L21SP2 RS17595
gene id: 1307761:L21SP2_RS17595
uniprot id: V5WMJ3
names: Function
names: Similarity
messages: Belongs to the bacterial histone-like protein family.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

1307761:L21SP2 RS06575
gene id: 1307761:L21SP2_RS06575
uniprot id: V5WI05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1307761:L21SP2 RS02370
gene id: 1307761:L21SP2_RS02370
uniprot id: V5WE59
names: Similarity
messages: Belongs to the DtxR/MntR family.

1307761:L21SP2 RS03995
gene id: 1307761:L21SP2_RS03995
uniprot id: V5WEN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1307761:L21SP2 RS13950
gene id: 1307761:L21SP2_RS13950
uniprot id: V5WKZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1307761:L21SP2 RS05625
gene id: 1307761:L21SP2_RS05625
uniprot id: V5WFL8
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

1307761:L21SP2 RS06660
gene id: 1307761:L21SP2_RS06660
uniprot id: V5WG99
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1307761:L21SP2 RS13515
gene id: 1307761:L21SP2_RS13515
uniprot id: V5WKZ6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1307761:L21SP2 RS08685
gene id: 1307761:L21SP2_RS08685
uniprot id: V5WHW9
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1307761:L21SP2 RS06990
gene id: 1307761:L21SP2_RS06990
uniprot id: V5WH45
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1307761:L21SP2 RS10120
gene id: 1307761:L21SP2_RS10120
uniprot id: V5WIR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PhyH family. EctD subfamily.
messages: Homodimer.
messages: Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.

1307761:L21SP2 RS06920
gene id: 1307761:L21SP2_RS06920
uniprot id: V5WGA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1307761:L21SP2 RS12680
gene id: 1307761:L21SP2_RS12680
uniprot id: V5WK89
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS03825
gene id: 1307761:L21SP2_RS03825
uniprot id: V5WEK4
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS08065
gene id: 1307761:L21SP2_RS08065
uniprot id: V5WH32
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS04870
gene id: 1307761:L21SP2_RS04870
uniprot id: V5WF75
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1307761:L21SP2 RS05920
gene id: 1307761:L21SP2_RS05920
uniprot id: V5WGB9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1307761:L21SP2 RS16585
gene id: 1307761:L21SP2_RS16585
uniprot id: V5WCS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1307761:L21SP2 RS07580
gene id: 1307761:L21SP2_RS07580
uniprot id: V5WH96
names: Similarity
messages: Belongs to the MEMO1 family.

1307761:L21SP2 RS01070
gene id: 1307761:L21SP2_RS01070
uniprot id: V5WES2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

1307761:L21SP2 RS14210
gene id: 1307761:L21SP2_RS14210
uniprot id: V5WKU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS01105
gene id: 1307761:L21SP2_RS01105
uniprot id: V5WDI6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1307761:L21SP2 RS07525
gene id: 1307761:L21SP2_RS07525
uniprot id: V5WIJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1307761:L21SP2 RS10185
gene id: 1307761:L21SP2_RS10185
uniprot id: V5WJ12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1307761:L21SP2 RS11390
gene id: 1307761:L21SP2_RS11390
uniprot id: V5WIU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1307761:L21SP2 RS17525
gene id: 1307761:L21SP2_RS17525
uniprot id: V5WKD3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS12410
gene id: 1307761:L21SP2_RS12410
uniprot id: V5WJN3
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1307761:L21SP2 RS00640
gene id: 1307761:L21SP2_RS00640
uniprot id: V5WCS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1307761:L21SP2 RS15960
gene id: 1307761:L21SP2_RS15960
uniprot id: V5WM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS02450
gene id: 1307761:L21SP2_RS02450
uniprot id: V5WEF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1307761:L21SP2 RS06155
gene id: 1307761:L21SP2_RS06155
uniprot id: V5WGG7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1307761:L21SP2 RS11920
gene id: 1307761:L21SP2_RS11920
uniprot id: V5WJ67
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1307761:L21SP2 RS16395
gene id: 1307761:L21SP2_RS16395
uniprot id: V5WNU5
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05755
gene id: 1307761:L21SP2_RS05755
uniprot id: V5WGF3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1307761:L21SP2 RS05145
gene id: 1307761:L21SP2_RS05145
uniprot id: V5WFE1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1307761:L21SP2 RS14195
gene id: 1307761:L21SP2_RS14195
uniprot id: V5WL39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1307761:L21SP2 RS05435
gene id: 1307761:L21SP2_RS05435
uniprot id: V5WG24
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS00625
gene id: 1307761:L21SP2_RS00625
uniprot id: V5WDE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS09020
gene id: 1307761:L21SP2_RS09020
uniprot id: V5WJD9
names: Subcellular Location Annotation
messages: Periplasmic flagellum

1307761:L21SP2 RS15490
gene id: 1307761:L21SP2_RS15490
uniprot id: V5WLZ9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

1307761:L21SP2 RS01220
gene id: 1307761:L21SP2_RS01220
uniprot id: V5WEV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1307761:L21SP2 RS11415
gene id: 1307761:L21SP2_RS11415
uniprot id: V5WIV6
names: Similarity
messages: Belongs to the RNA polymerase subunit omega family.

1307761:L21SP2 RS00910
gene id: 1307761:L21SP2_RS00910
uniprot id: V5WCW8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1307761:L21SP2 RS08885
gene id: 1307761:L21SP2_RS08885
uniprot id: V5WHG3
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

1307761:L21SP2 RS12085
gene id: 1307761:L21SP2_RS12085
uniprot id: V5WJG1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1307761:L21SP2 RS16985
gene id: 1307761:L21SP2_RS16985
uniprot id: V5WGQ4
names: Similarity
messages: Belongs to the TlyA family.

1307761:L21SP2 RS04160
gene id: 1307761:L21SP2_RS04160
uniprot id: V5WER5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1307761:L21SP2 RS11610
gene id: 1307761:L21SP2_RS11610
uniprot id: V5WJK1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1307761:L21SP2 RS08825
gene id: 1307761:L21SP2_RS08825
uniprot id: V5WJ97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1307761:L21SP2 RS02965
gene id: 1307761:L21SP2_RS02965
uniprot id: V5WEV0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS13530
gene id: 1307761:L21SP2_RS13530
uniprot id: V5WK78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1307761:L21SP2 RS09375
gene id: 1307761:L21SP2_RS09375
uniprot id: V5WJK3
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1307761:L21SP2 RS14805
gene id: 1307761:L21SP2_RS14805
uniprot id: V5WMS3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1307761:L21SP2 RS13025
gene id: 1307761:L21SP2_RS13025
uniprot id: V5WKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS11680
gene id: 1307761:L21SP2_RS11680
uniprot id: V5WKW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS14085
gene id: 1307761:L21SP2_RS14085
uniprot id: V5WKJ2
names: Similarity
messages: Belongs to the Dps family.

1307761:L21SP2 RS12790
gene id: 1307761:L21SP2_RS12790
uniprot id: V5WJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1307761:L21SP2 RS07115
gene id: 1307761:L21SP2_RS07115
uniprot id: V5WGJ6
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS07245
gene id: 1307761:L21SP2_RS07245
uniprot id: V5WGH2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1307761:L21SP2 RS14190
gene id: 1307761:L21SP2_RS14190
uniprot id: V5WLC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1307761:L21SP2 RS00935
gene id: 1307761:L21SP2_RS00935
uniprot id: V5WCV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1307761:L21SP2 RS10720
gene id: 1307761:L21SP2_RS10720
uniprot id: V5WIH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1307761:L21SP2 RS01155
gene id: 1307761:L21SP2_RS01155
uniprot id: V5WDP3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

1307761:L21SP2 RS02825
gene id: 1307761:L21SP2_RS02825
uniprot id: V5WEI9
names: Similarity
messages: Belongs to the DtxR/MntR family.

1307761:L21SP2 RS06775
gene id: 1307761:L21SP2_RS06775
uniprot id: V5WG74
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1307761:L21SP2 RS10010
gene id: 1307761:L21SP2_RS10010
uniprot id: V5WJY1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

1307761:L21SP2 RS02155
gene id: 1307761:L21SP2_RS02155
uniprot id: V5WE13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1307761:L21SP2 RS04015
gene id: 1307761:L21SP2_RS04015
uniprot id: V5WGI9
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1307761:L21SP2 RS13245
gene id: 1307761:L21SP2_RS13245
uniprot id: V5WK80
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS17065
gene id: 1307761:L21SP2_RS17065
uniprot id: V5WI94
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS03460
gene id: 1307761:L21SP2_RS03460
uniprot id: V5WG73
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1307761:L21SP2 RS07520
gene id: 1307761:L21SP2_RS07520
uniprot id: V5WH85
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1307761:L21SP2 RS03860
gene id: 1307761:L21SP2_RS03860
uniprot id: V5WGG0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS00800
gene id: 1307761:L21SP2_RS00800
uniprot id: V5WDD3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS07505
gene id: 1307761:L21SP2_RS07505
uniprot id: V5WGM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1307761:L21SP2 RS06685
gene id: 1307761:L21SP2_RS06685
uniprot id: V5WG54
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1307761:L21SP2 RS01615
gene id: 1307761:L21SP2_RS01615
uniprot id: V5WDX7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS13985
gene id: 1307761:L21SP2_RS13985
uniprot id: V5WKG7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1307761:L21SP2 RS09410
gene id: 1307761:L21SP2_RS09410
uniprot id: V5WHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS10305
gene id: 1307761:L21SP2_RS10305
uniprot id: V5WIA4
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1307761:L21SP2 RS09480
gene id: 1307761:L21SP2_RS09480
uniprot id: V5WHT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS06700
gene id: 1307761:L21SP2_RS06700
uniprot id: V5WGY2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1307761:L21SP2 RS12395
gene id: 1307761:L21SP2_RS12395
uniprot id: V5WK64
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1307761:L21SP2 RS12060
gene id: 1307761:L21SP2_RS12060
uniprot id: V5WJF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1307761:L21SP2 RS08830
gene id: 1307761:L21SP2_RS08830
uniprot id: V5WHC9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307761:L21SP2 RS16355
gene id: 1307761:L21SP2_RS16355
uniprot id: V5WME1
names: Similarity
messages: Belongs to the CapA family.

1307761:L21SP2 RS13635
gene id: 1307761:L21SP2_RS13635
uniprot id: V5WL17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1307761:L21SP2 RS05535
gene id: 1307761:L21SP2_RS05535
uniprot id: V5WFN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS06250
gene id: 1307761:L21SP2_RS06250
uniprot id: V5WG09
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

1307761:L21SP2 RS05610
gene id: 1307761:L21SP2_RS05610
uniprot id: V5WGC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

1307761:L21SP2 RS05570
gene id: 1307761:L21SP2_RS05570
uniprot id: V5WHF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

1307761:L21SP2 RS11090
gene id: 1307761:L21SP2_RS11090
uniprot id: V5WIS5
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1307761:L21SP2 RS01945
gene id: 1307761:L21SP2_RS01945
uniprot id: V5WDX9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1307761:L21SP2 RS11745
gene id: 1307761:L21SP2_RS11745
uniprot id: V5WJM3
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1307761:L21SP2 RS02670
gene id: 1307761:L21SP2_RS02670
uniprot id: V5WDY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1307761:L21SP2 RS17390
gene id: 1307761:L21SP2_RS17390
uniprot id: V5WJ96
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1307761:L21SP2 RS06300
gene id: 1307761:L21SP2_RS06300
uniprot id: V5WFY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1307761:L21SP2 RS17235
gene id: 1307761:L21SP2_RS17235
uniprot id: V5WHR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS15865
gene id: 1307761:L21SP2_RS15865
uniprot id: V5WNA9
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1307761:L21SP2 RS08965
gene id: 1307761:L21SP2_RS08965
uniprot id: V5WJD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1307761:L21SP2 RS03080
gene id: 1307761:L21SP2_RS03080
uniprot id: V5WEN7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1307761:L21SP2 RS01345
gene id: 1307761:L21SP2_RS01345
uniprot id: V5WD26
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1307761:L21SP2 RS12765
gene id: 1307761:L21SP2_RS12765
uniprot id: V5WJT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1307761:L21SP2 RS04325
gene id: 1307761:L21SP2_RS04325
uniprot id: V5WEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1307761:L21SP2 RS02435
gene id: 1307761:L21SP2_RS02435
uniprot id: V5WFI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1307761:L21SP2 RS08555
gene id: 1307761:L21SP2_RS08555
uniprot id: V5WHU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1307761:L21SP2 RS12870
gene id: 1307761:L21SP2_RS12870
uniprot id: V5WJV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS08595
gene id: 1307761:L21SP2_RS08595
uniprot id: V5WHV0
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1307761:L21SP2 RS04090
gene id: 1307761:L21SP2_RS04090
uniprot id: V5WFG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1307761:L21SP2 RS12620
gene id: 1307761:L21SP2_RS12620
uniprot id: V5WJX0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS00225
gene id: 1307761:L21SP2_RS00225
uniprot id: V5WD49
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1307761:L21SP2 RS11375
gene id: 1307761:L21SP2_RS11375
uniprot id: V5WJM1
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1307761:L21SP2 RS16930
gene id: 1307761:L21SP2_RS16930
uniprot id: V5WFZ3
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS08975
gene id: 1307761:L21SP2_RS08975
uniprot id: V5WHI3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1307761:L21SP2 RS08655
gene id: 1307761:L21SP2_RS08655
uniprot id: V5WI38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1307761:L21SP2 RS01970
gene id: 1307761:L21SP2_RS01970
uniprot id: V5WF86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

1307761:L21SP2 RS14425
gene id: 1307761:L21SP2_RS14425
uniprot id: V5WKR4
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05860
gene id: 1307761:L21SP2_RS05860
uniprot id: V5WFT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1307761:L21SP2 RS10150
gene id: 1307761:L21SP2_RS10150
uniprot id: V5WK21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS10145
gene id: 1307761:L21SP2_RS10145
uniprot id: V5WIS8
names: Subcellular Location Annotation
messages: Cytoplasm

1307761:L21SP2 RS05515
gene id: 1307761:L21SP2_RS05515
uniprot id: V5WFM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

1307761:L21SP2 RS03280
gene id: 1307761:L21SP2_RS03280
uniprot id: V5WF15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS11445
gene id: 1307761:L21SP2_RS11445
uniprot id: V5WJ07
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS05255
gene id: 1307761:L21SP2_RS05255
uniprot id: V5WFI0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1307761:L21SP2 RS00200
gene id: 1307761:L21SP2_RS00200
uniprot id: V5WD44
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1307761:L21SP2 RS13615
gene id: 1307761:L21SP2_RS13615
uniprot id: V5WKR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1307761:L21SP2 RS09505
gene id: 1307761:L21SP2_RS09505
uniprot id: V5WHU1
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS06365
gene id: 1307761:L21SP2_RS06365
uniprot id: V5WGK4
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1307761:L21SP2 RS10325
gene id: 1307761:L21SP2_RS10325
uniprot id: V5WK45
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

1307761:L21SP2 RS05025
gene id: 1307761:L21SP2_RS05025
uniprot id: V5WFS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS08450
gene id: 1307761:L21SP2_RS08450
uniprot id: V5WHR8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1307761:L21SP2 RS11115
gene id: 1307761:L21SP2_RS11115
uniprot id: V5WIT0
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1307761:L21SP2 RS09450
gene id: 1307761:L21SP2_RS09450
uniprot id: V5WJL8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1307761:L21SP2 RS09445
gene id: 1307761:L21SP2_RS09445
uniprot id: V5WIA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS06515
gene id: 1307761:L21SP2_RS06515
uniprot id: V5WG65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1307761:L21SP2 RS00025
gene id: 1307761:L21SP2_RS00025
uniprot id: V5WE63
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1307761:L21SP2 RS14485
gene id: 1307761:L21SP2_RS14485
uniprot id: V5WLA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS04355
gene id: 1307761:L21SP2_RS04355
uniprot id: V5WGR6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1307761:L21SP2 RS04310
gene id: 1307761:L21SP2_RS04310
uniprot id: V5WFC8
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

1307761:L21SP2 RS00070
gene id: 1307761:L21SP2_RS00070
uniprot id: V5WCF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1307761:L21SP2 RS10430
gene id: 1307761:L21SP2_RS10430
uniprot id: V5WIX8
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS00395
gene id: 1307761:L21SP2_RS00395
uniprot id: V5WCL6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1307761:L21SP2 RS03525
gene id: 1307761:L21SP2_RS03525
uniprot id: V5WF60
names: Similarity
messages: Belongs to the UPF0758 family.

1307761:L21SP2 RS00455
gene id: 1307761:L21SP2_RS00455
uniprot id: V5WCM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1307761:L21SP2 RS07405
gene id: 1307761:L21SP2_RS07405
uniprot id: V5WH63
names: Similarity
messages: Belongs to the peptidase S66 family.

1307761:L21SP2 RS04185
gene id: 1307761:L21SP2_RS04185
uniprot id: V5WES1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1307761:L21SP2 RS15005
gene id: 1307761:L21SP2_RS15005
uniprot id: V5WLQ1
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS09630
gene id: 1307761:L21SP2_RS09630
uniprot id: V5WHX1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1307761:L21SP2 RS06350
gene id: 1307761:L21SP2_RS06350
uniprot id: V5WFZ0
names: Similarity
messages: Belongs to the pirin family.

1307761:L21SP2 RS01540
gene id: 1307761:L21SP2_RS01540
uniprot id: V5WDW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1307761:L21SP2 RS05720
gene id: 1307761:L21SP2_RS05720
uniprot id: V5WFN4
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1307761:L21SP2 RS06140
gene id: 1307761:L21SP2_RS06140
uniprot id: V5WGG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS08980
gene id: 1307761:L21SP2_RS08980
uniprot id: V5WI87
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1307761:L21SP2 RS04150
gene id: 1307761:L21SP2_RS04150
uniprot id: V5WGM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1307761:L21SP2 RS05690
gene id: 1307761:L21SP2_RS05690
uniprot id: V5WHH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1307761:L21SP2 RS00940
gene id: 1307761:L21SP2_RS00940
uniprot id: V5WDK3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS05420
gene id: 1307761:L21SP2_RS05420
uniprot id: V5WFI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1307761:L21SP2 RS16665
gene id: 1307761:L21SP2_RS16665
uniprot id: V5WD72
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1307761:L21SP2 RS07600
gene id: 1307761:L21SP2_RS07600
uniprot id: V5WHI6
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.

1307761:L21SP2 RS14695
gene id: 1307761:L21SP2_RS14695
uniprot id: V5WMQ7
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS08255
gene id: 1307761:L21SP2_RS08255
uniprot id: V5WHN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1307761:L21SP2 RS14430
gene id: 1307761:L21SP2_RS14430
uniprot id: V5WKZ3
names: Similarity
messages: Belongs to the leucine-binding protein family.

1307761:L21SP2 RS16750
gene id: 1307761:L21SP2_RS16750
uniprot id: V5WEH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS12855
gene id: 1307761:L21SP2_RS12855
uniprot id: V5WKK7
names: Subcellular Location Annotation
messages: Cytoplasm

1307761:L21SP2 RS10455
gene id: 1307761:L21SP2_RS10455
uniprot id: V5WIY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

1307761:L21SP2 RS01580
gene id: 1307761:L21SP2_RS01580
uniprot id: V5WD64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1307761:L21SP2 RS01315
gene id: 1307761:L21SP2_RS01315
uniprot id: V5WD47
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1307761:L21SP2 RS02695
gene id: 1307761:L21SP2_RS02695
uniprot id: V5WDZ1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1307761:L21SP2 RS06455
gene id: 1307761:L21SP2_RS06455
uniprot id: V5WGT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS01385
gene id: 1307761:L21SP2_RS01385
uniprot id: V5WDN6
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1307761:L21SP2 RS12155
gene id: 1307761:L21SP2_RS12155
uniprot id: V5WK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1307761:L21SP2 RS04215
gene id: 1307761:L21SP2_RS04215
uniprot id: V5WFI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1307761:L21SP2 RS04230
gene id: 1307761:L21SP2_RS04230
uniprot id: V5WEU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1307761:L21SP2 RS04885
gene id: 1307761:L21SP2_RS04885
uniprot id: V5WH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1307761:L21SP2 RS04220
gene id: 1307761:L21SP2_RS04220
uniprot id: V5WFA9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1307761:L21SP2 RS04265
gene id: 1307761:L21SP2_RS04265
uniprot id: V5WFJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1307761:L21SP2 RS08510
gene id: 1307761:L21SP2_RS08510
uniprot id: V5WH72
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1307761:L21SP2 RS13275
gene id: 1307761:L21SP2_RS13275
uniprot id: V5WKU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1307761:L21SP2 RS12915
gene id: 1307761:L21SP2_RS12915
uniprot id: V5WKC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1307761:L21SP2 RS01510
gene id: 1307761:L21SP2_RS01510
uniprot id: V5WDV9
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS03725
gene id: 1307761:L21SP2_RS03725
uniprot id: V5WEI2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1307761:L21SP2 RS05520
gene id: 1307761:L21SP2_RS05520
uniprot id: V5WGB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1307761:L21SP2 RS01050
gene id: 1307761:L21SP2_RS01050
uniprot id: V5WCZ6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1307761:L21SP2 RS03580
gene id: 1307761:L21SP2_RS03580
uniprot id: V5WG98
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1307761:L21SP2 RS17105
gene id: 1307761:L21SP2_RS17105
uniprot id: V5WGT6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1307761:L21SP2 RS13655
gene id: 1307761:L21SP2_RS13655
uniprot id: V5WKH0
names: Similarity
messages: Belongs to the UPF0145 family.

1307761:L21SP2 RS07000
gene id: 1307761:L21SP2_RS07000
uniprot id: V5WI80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS15850
gene id: 1307761:L21SP2_RS15850
uniprot id: V5WNR5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1307761:L21SP2 RS09775
gene id: 1307761:L21SP2_RS09775
uniprot id: V5WI07
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1307761:L21SP2 RS01075
gene id: 1307761:L21SP2_RS01075
uniprot id: V5WD02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS10960
gene id: 1307761:L21SP2_RS10960
uniprot id: V5WIL6
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1307761:L21SP2 RS10705
gene id: 1307761:L21SP2_RS10705
uniprot id: V5WJA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

1307761:L21SP2 RS02025
gene id: 1307761:L21SP2_RS02025
uniprot id: V5WDF6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1307761:L21SP2 RS15465
gene id: 1307761:L21SP2_RS15465
uniprot id: V5WLZ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1307761:L21SP2 RS06805
gene id: 1307761:L21SP2_RS06805
uniprot id: V5WG80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1307761:L21SP2 RS16300
gene id: 1307761:L21SP2_RS16300
uniprot id: V5WNU1
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1307761:L21SP2 RS14095
gene id: 1307761:L21SP2_RS14095
uniprot id: V5WLB5
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1307761:L21SP2 RS07695
gene id: 1307761:L21SP2_RS07695
uniprot id: V5WGW9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1307761:L21SP2 RS07920
gene id: 1307761:L21SP2_RS07920
uniprot id: V5WHR0
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1307761:L21SP2 RS03560
gene id: 1307761:L21SP2_RS03560
uniprot id: V5WG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS00050
gene id: 1307761:L21SP2_RS00050
uniprot id: V5WCE8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1307761:L21SP2 RS13790
gene id: 1307761:L21SP2_RS13790
uniprot id: V5WL43
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

1307761:L21SP2 RS08210
gene id: 1307761:L21SP2_RS08210
uniprot id: V5WHV6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1307761:L21SP2 RS01080
gene id: 1307761:L21SP2_RS01080
uniprot id: V5WCX5
names: Similarity
messages: Belongs to the histone deacetylase family.

1307761:L21SP2 RS12875
gene id: 1307761:L21SP2_RS12875
uniprot id: V5WK12
names: Similarity
messages: Belongs to the UPF0045 family.

1307761:L21SP2 RS13510
gene id: 1307761:L21SP2_RS13510
uniprot id: V5WKD7
names: Similarity
messages: Belongs to the citrate synthase family.

1307761:L21SP2 RS01390
gene id: 1307761:L21SP2_RS01390
uniprot id: V5WEY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1307761:L21SP2 RS16730
gene id: 1307761:L21SP2_RS16730
uniprot id: V5WDL8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1307761:L21SP2 RS00840
gene id: 1307761:L21SP2_RS00840
uniprot id: V5WCT5
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1307761:L21SP2 RS05500
gene id: 1307761:L21SP2_RS05500
uniprot id: V5WG36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1307761:L21SP2 RS06370
gene id: 1307761:L21SP2_RS06370
uniprot id: V5WHW0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1307761:L21SP2 RS05445
gene id: 1307761:L21SP2_RS05445
uniprot id: V5WFI3
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS02580
gene id: 1307761:L21SP2_RS02580
uniprot id: V5WDU0
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

1307761:L21SP2 RS03675
gene id: 1307761:L21SP2_RS03675
uniprot id: V5WGC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1307761:L21SP2 RS11510
gene id: 1307761:L21SP2_RS11510
uniprot id: V5WKS1
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS01515
gene id: 1307761:L21SP2_RS01515
uniprot id: V5WDR1
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS04145
gene id: 1307761:L21SP2_RS04145
uniprot id: V5WF95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1307761:L21SP2 RS00055
gene id: 1307761:L21SP2_RS00055
uniprot id: V5WCE5
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

1307761:L21SP2 RS12300
gene id: 1307761:L21SP2_RS12300
uniprot id: V5WJX2
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

1307761:L21SP2 RS14950
gene id: 1307761:L21SP2_RS14950
uniprot id: V5WLN9
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1307761:L21SP2 RS08700
gene id: 1307761:L21SP2_RS08700
uniprot id: V5WHD1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1307761:L21SP2 RS10300
gene id: 1307761:L21SP2_RS10300
uniprot id: V5WK41
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

1307761:L21SP2 RS00630
gene id: 1307761:L21SP2_RS00630
uniprot id: V5WDA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

1307761:L21SP2 RS08480
gene id: 1307761:L21SP2_RS08480
uniprot id: V5WJ24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS13285
gene id: 1307761:L21SP2_RS13285
uniprot id: V5WM40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS03700
gene id: 1307761:L21SP2_RS03700
uniprot id: V5WEH8
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS13670
gene id: 1307761:L21SP2_RS13670
uniprot id: V5WM88
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1307761:L21SP2 RS06050
gene id: 1307761:L21SP2_RS06050
uniprot id: V5WFT7
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1307761:L21SP2 RS11045
gene id: 1307761:L21SP2_RS11045
uniprot id: V5WJ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1307761:L21SP2 RS12920
gene id: 1307761:L21SP2_RS12920
uniprot id: V5WLX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1307761:L21SP2 RS15010
gene id: 1307761:L21SP2_RS15010
uniprot id: V5WNG5
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1307761:L21SP2 RS15285
gene id: 1307761:L21SP2_RS15285
uniprot id: V5WLT9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS05440
gene id: 1307761:L21SP2_RS05440
uniprot id: V5WHC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS09430
gene id: 1307761:L21SP2_RS09430
uniprot id: V5WHQ2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS11030
gene id: 1307761:L21SP2_RS11030
uniprot id: V5WKG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1307761:L21SP2 RS08570
gene id: 1307761:L21SP2_RS08570
uniprot id: V5WHA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1307761:L21SP2 RS17735
gene id: 1307761:L21SP2_RS17735
uniprot id: V5WMB5
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1307761:L21SP2 RS13555
gene id: 1307761:L21SP2_RS13555
uniprot id: V5WKE8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1307761:L21SP2 RS10055
gene id: 1307761:L21SP2_RS10055
uniprot id: V5WIN4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1307761:L21SP2 RS12160
gene id: 1307761:L21SP2_RS12160
uniprot id: V5WJU2
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS07860
gene id: 1307761:L21SP2_RS07860
uniprot id: V5WHH2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1307761:L21SP2 RS08405
gene id: 1307761:L21SP2_RS08405
uniprot id: V5WJ10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

1307761:L21SP2 RS08085
gene id: 1307761:L21SP2_RS08085
uniprot id: V5WHK4
names: Similarity
messages: Belongs to the BMP lipoprotein family.

1307761:L21SP2 RS04775
gene id: 1307761:L21SP2_RS04775
uniprot id: V5WFM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1307761:L21SP2 RS08565
gene id: 1307761:L21SP2_RS08565
uniprot id: V5WH81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1307761:L21SP2 RS09220
gene id: 1307761:L21SP2_RS09220
uniprot id: V5WIB9
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS04810
gene id: 1307761:L21SP2_RS04810
uniprot id: V5WF68
names: Similarity
messages: Belongs to the carbamate kinase family.

1307761:L21SP2 RS05800
gene id: 1307761:L21SP2_RS05800
uniprot id: V5WGG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Periplasm
messages: Periplasmic flagellum
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.

1307761:L21SP2 RS04645
gene id: 1307761:L21SP2_RS04645
uniprot id: V5WFR7
names: Similarity
messages: Belongs to the DtxR/MntR family.

1307761:L21SP2 RS14530
gene id: 1307761:L21SP2_RS14530
uniprot id: V5WKT4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1307761:L21SP2 RS05185
gene id: 1307761:L21SP2_RS05185
uniprot id: V5WH93
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1307761:L21SP2 RS01250
gene id: 1307761:L21SP2_RS01250
uniprot id: V5WD08
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05915
gene id: 1307761:L21SP2_RS05915
uniprot id: V5WGI7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1307761:L21SP2 RS04675
gene id: 1307761:L21SP2_RS04675
uniprot id: V5WGW7
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS10480
gene id: 1307761:L21SP2_RS10480
uniprot id: V5WIY6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1307761:L21SP2 RS02575
gene id: 1307761:L21SP2_RS02575
uniprot id: V5WDV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1307761:L21SP2 RS05170
gene id: 1307761:L21SP2_RS05170
uniprot id: V5WFG2
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1307761:L21SP2 RS02070
gene id: 1307761:L21SP2_RS02070
uniprot id: V5WDJ9
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1307761:L21SP2 RS17170
gene id: 1307761:L21SP2_RS17170
uniprot id: V5WH77
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05845
gene id: 1307761:L21SP2_RS05845
uniprot id: V5WGA6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1307761:L21SP2 RS14000
gene id: 1307761:L21SP2_RS14000
uniprot id: V5WL01
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS02200
gene id: 1307761:L21SP2_RS02200
uniprot id: V5WE91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1307761:L21SP2 RS07120
gene id: 1307761:L21SP2_RS07120
uniprot id: V5WH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

1307761:L21SP2 RS05760
gene id: 1307761:L21SP2_RS05760
uniprot id: V5WG87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasmic flagellum

1307761:L21SP2 RS12975
gene id: 1307761:L21SP2_RS12975
uniprot id: V5WK29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1307761:L21SP2 RS03540
gene id: 1307761:L21SP2_RS03540
uniprot id: V5WEE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS12420
gene id: 1307761:L21SP2_RS12420
uniprot id: V5WK00
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1307761:L21SP2 RS16240
gene id: 1307761:L21SP2_RS16240
uniprot id: V5WNG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1307761:L21SP2 RS14995
gene id: 1307761:L21SP2_RS14995
uniprot id: V5WLP6
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1307761:L21SP2 RS05490
gene id: 1307761:L21SP2_RS05490
uniprot id: V5WFM0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1307761:L21SP2 RS07970
gene id: 1307761:L21SP2_RS07970
uniprot id: V5WHJ3
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS10435
gene id: 1307761:L21SP2_RS10435
uniprot id: V5WK65
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1307761:L21SP2 RS06715
gene id: 1307761:L21SP2_RS06715
uniprot id: V5WGB1
names: Similarity
messages: Belongs to the glutamate synthase family.

1307761:L21SP2 RS04910
gene id: 1307761:L21SP2_RS04910
uniprot id: V5WH19
names: Similarity
messages: Belongs to the YggT family.

1307761:L21SP2 RS13640
gene id: 1307761:L21SP2_RS13640
uniprot id: V5WKS3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1307761:L21SP2 RS06215
gene id: 1307761:L21SP2_RS06215
uniprot id: V5WFW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1307761:L21SP2 RS06490
gene id: 1307761:L21SP2_RS06490
uniprot id: V5WG17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS00350
gene id: 1307761:L21SP2_RS00350
uniprot id: V5WDA0
names: Similarity
messages: Belongs to the threonine synthase family.

1307761:L21SP2 RS00065
gene id: 1307761:L21SP2_RS00065
uniprot id: V5WE76
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1307761:L21SP2 RS08625
gene id: 1307761:L21SP2_RS08625
uniprot id: V5WJ57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1307761:L21SP2 RS00375
gene id: 1307761:L21SP2_RS00375
uniprot id: V5WDA5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS11955
gene id: 1307761:L21SP2_RS11955
uniprot id: V5WJW8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1307761:L21SP2 RS09495
gene id: 1307761:L21SP2_RS09495
uniprot id: V5WJM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS07515
gene id: 1307761:L21SP2_RS07515
uniprot id: V5WHF9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1307761:L21SP2 RS00265
gene id: 1307761:L21SP2_RS00265
uniprot id: V5WCJ9
names: Similarity
messages: Belongs to the peptidase S41A family.

1307761:L21SP2 RS00340
gene id: 1307761:L21SP2_RS00340
uniprot id: V5WCM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS16495
gene id: 1307761:L21SP2_RS16495
uniprot id: V5WMG1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

1307761:L21SP2 RS11380
gene id: 1307761:L21SP2_RS11380
uniprot id: V5WJF2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS00855
gene id: 1307761:L21SP2_RS00855
uniprot id: V5WEN1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1307761:L21SP2 RS08890
gene id: 1307761:L21SP2_RS08890
uniprot id: V5WI72
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

1307761:L21SP2 RS08610
gene id: 1307761:L21SP2_RS08610
uniprot id: V5WHB6
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS09970
gene id: 1307761:L21SP2_RS09970
uniprot id: V5WJW9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS03720
gene id: 1307761:L21SP2_RS03720
uniprot id: V5WEI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

1307761:L21SP2 RS04780
gene id: 1307761:L21SP2_RS04780
uniprot id: V5WGZ1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Monomer. Binds crRNA and tracrRNA.

1307761:L21SP2 RS09760
gene id: 1307761:L21SP2_RS09760
uniprot id: V5WIH0
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1307761:L21SP2 RS11480
gene id: 1307761:L21SP2_RS11480
uniprot id: V5WJH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

1307761:L21SP2 RS04745
gene id: 1307761:L21SP2_RS04745
uniprot id: V5WFL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

1307761:L21SP2 RS15235
gene id: 1307761:L21SP2_RS15235
uniprot id: V5WL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

1307761:L21SP2 RS13020
gene id: 1307761:L21SP2_RS13020
uniprot id: V5WK36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS10130
gene id: 1307761:L21SP2_RS10130
uniprot id: V5WI77
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.

1307761:L21SP2 RS11335
gene id: 1307761:L21SP2_RS11335
uniprot id: V5WKN6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1307761:L21SP2 RS15220
gene id: 1307761:L21SP2_RS15220
uniprot id: V5WN30
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307761:L21SP2 RS02280
gene id: 1307761:L21SP2_RS02280
uniprot id: V5WFE6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1307761:L21SP2 RS15535
gene id: 1307761:L21SP2_RS15535
uniprot id: V5WN68
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1307761:L21SP2 RS08020
gene id: 1307761:L21SP2_RS08020
uniprot id: V5WIV5
names: Similarity
messages: Belongs to the YoeB family.

1307761:L21SP2 RS11895
gene id: 1307761:L21SP2_RS11895
uniprot id: V5WJP1
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1307761:L21SP2 RS12020
gene id: 1307761:L21SP2_RS12020
uniprot id: V5WJE5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS05810
gene id: 1307761:L21SP2_RS05810
uniprot id: V5WHJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

1307761:L21SP2 RS04180
gene id: 1307761:L21SP2_RS04180
uniprot id: V5WET1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1307761:L21SP2 RS04190
gene id: 1307761:L21SP2_RS04190
uniprot id: V5WFH8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1307761:L21SP2 RS04890
gene id: 1307761:L21SP2_RS04890
uniprot id: V5WF84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1307761:L21SP2 RS08960
gene id: 1307761:L21SP2_RS08960
uniprot id: V5WI83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1307761:L21SP2 RS09710
gene id: 1307761:L21SP2_RS09710
uniprot id: V5WIM3
names: Similarity
messages: Belongs to the universal stress protein A family.

1307761:L21SP2 RS14675
gene id: 1307761:L21SP2_RS14675
uniprot id: V5WKW4
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1307761:L21SP2 RS11200
gene id: 1307761:L21SP2_RS11200
uniprot id: V5WIV1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS15015
gene id: 1307761:L21SP2_RS15015
uniprot id: V5WL52
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1307761:L21SP2 RS10970
gene id: 1307761:L21SP2_RS10970
uniprot id: V5WJE6
names: Similarity
messages: Belongs to the UPF0047 family.

1307761:L21SP2 RS04720
gene id: 1307761:L21SP2_RS04720
uniprot id: V5WFK8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

1307761:L21SP2 RS09520
gene id: 1307761:L21SP2_RS09520
uniprot id: V5WJN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

1307761:L21SP2 RS00205
gene id: 1307761:L21SP2_RS00205
uniprot id: V5WD12
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1307761:L21SP2 RS06160
gene id: 1307761:L21SP2_RS06160
uniprot id: V5WHR9
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1307761:L21SP2 RS16125
gene id: 1307761:L21SP2_RS16125
uniprot id: V5WLH6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1307761:L21SP2 RS08260
gene id: 1307761:L21SP2_RS08260
uniprot id: V5WIY9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1307761:L21SP2 RS04330
gene id: 1307761:L21SP2_RS04330
uniprot id: V5WFL1
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1307761:L21SP2 RS08865
gene id: 1307761:L21SP2_RS08865
uniprot id: V5WI68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1307761:L21SP2 RS01635
gene id: 1307761:L21SP2_RS01635
uniprot id: V5WDY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1307761:L21SP2 RS08800
gene id: 1307761:L21SP2_RS08800
uniprot id: V5WJ92
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1307761:L21SP2 RS01800
gene id: 1307761:L21SP2_RS01800
uniprot id: V5WDA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS04170
gene id: 1307761:L21SP2_RS04170
uniprot id: V5WF99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1307761:L21SP2 RS05510
gene id: 1307761:L21SP2_RS05510
uniprot id: V5WFJ7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1307761:L21SP2 RS10345
gene id: 1307761:L21SP2_RS10345
uniprot id: V5WIW3
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS01055
gene id: 1307761:L21SP2_RS01055
uniprot id: V5WCX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1307761:L21SP2 RS10700
gene id: 1307761:L21SP2_RS10700
uniprot id: V5WIL5
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1307761:L21SP2 RS04695
gene id: 1307761:L21SP2_RS04695
uniprot id: V5WFK2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1307761:L21SP2 RS02465
gene id: 1307761:L21SP2_RS02465
uniprot id: V5WDT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1307761:L21SP2 RS14175
gene id: 1307761:L21SP2_RS14175
uniprot id: V5WMH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1307761:L21SP2 RS10175
gene id: 1307761:L21SP2_RS10175
uniprot id: V5WK24
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05575
gene id: 1307761:L21SP2_RS05575
uniprot id: V5WFK9
names: Similarity
messages: Belongs to the MotB family.

1307761:L21SP2 RS07865
gene id: 1307761:L21SP2_RS07865
uniprot id: V5WIS6
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS02290
gene id: 1307761:L21SP2_RS02290
uniprot id: V5WDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1307761:L21SP2 RS01140
gene id: 1307761:L21SP2_RS01140
uniprot id: V5WET6
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1307761:L21SP2 RS11715
gene id: 1307761:L21SP2_RS11715
uniprot id: V5WJS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1307761:L21SP2 RS00695
gene id: 1307761:L21SP2_RS00695
uniprot id: V5WDG2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1307761:L21SP2 RS04165
gene id: 1307761:L21SP2_RS04165
uniprot id: V5WFH6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1307761:L21SP2 RS03880
gene id: 1307761:L21SP2_RS03880
uniprot id: V5WF43
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS08920
gene id: 1307761:L21SP2_RS08920
uniprot id: V5WJB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1307761:L21SP2 RS13775
gene id: 1307761:L21SP2_RS13775
uniprot id: V5WMA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS09215
gene id: 1307761:L21SP2_RS09215
uniprot id: V5WHM0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS04630
gene id: 1307761:L21SP2_RS04630
uniprot id: V5WGV4
names: Similarity
messages: Belongs to the peptidase S1C family.

1307761:L21SP2 RS15965
gene id: 1307761:L21SP2_RS15965
uniprot id: V5WNC2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1307761:L21SP2 RS12390
gene id: 1307761:L21SP2_RS12390
uniprot id: V5WJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS15245
gene id: 1307761:L21SP2_RS15245
uniprot id: V5WN33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1307761:L21SP2 RS12720
gene id: 1307761:L21SP2_RS12720
uniprot id: V5WJS9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1307761:L21SP2 RS01400
gene id: 1307761:L21SP2_RS01400
uniprot id: V5WD33
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1307761:L21SP2 RS16635
gene id: 1307761:L21SP2_RS16635
uniprot id: V5WD24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS00930
gene id: 1307761:L21SP2_RS00930
uniprot id: V5WCX2
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS00865
gene id: 1307761:L21SP2_RS00865
uniprot id: V5WCT9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1307761:L21SP2 RS06795
gene id: 1307761:L21SP2_RS06795
uniprot id: V5WGT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1307761:L21SP2 RS05765
gene id: 1307761:L21SP2_RS05765
uniprot id: V5WHI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

1307761:L21SP2 RS04280
gene id: 1307761:L21SP2_RS04280
uniprot id: V5WFK0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS04175
gene id: 1307761:L21SP2_RS04175
uniprot id: V5WGM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1307761:L21SP2 RS14775
gene id: 1307761:L21SP2_RS14775
uniprot id: V5WMR9
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS04640
gene id: 1307761:L21SP2_RS04640
uniprot id: V5WF25
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS03545
gene id: 1307761:L21SP2_RS03545
uniprot id: V5WEE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS05385
gene id: 1307761:L21SP2_RS05385
uniprot id: V5WG16
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1307761:L21SP2 RS11530
gene id: 1307761:L21SP2_RS11530
uniprot id: V5WJI1
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1307761:L21SP2 RS15610
gene id: 1307761:L21SP2_RS15610
uniprot id: V5WLZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1307761:L21SP2 RS12745
gene id: 1307761:L21SP2_RS12745
uniprot id: V5WJT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1307761:L21SP2 RS14560
gene id: 1307761:L21SP2_RS14560
uniprot id: V5WKT9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS03635
gene id: 1307761:L21SP2_RS03635
uniprot id: V5WEG4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1307761:L21SP2 RS13380
gene id: 1307761:L21SP2_RS13380
uniprot id: V5WKX0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1307761:L21SP2 RS17005
gene id: 1307761:L21SP2_RS17005
uniprot id: V5WGU6
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1307761:L21SP2 RS12785
gene id: 1307761:L21SP2_RS12785
uniprot id: V5WLV5
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1307761:L21SP2 RS16095
gene id: 1307761:L21SP2_RS16095
uniprot id: V5WNT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS05015
gene id: 1307761:L21SP2_RS05015
uniprot id: V5WFB1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1307761:L21SP2 RS04100
gene id: 1307761:L21SP2_RS04100
uniprot id: V5WGL2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1307761:L21SP2 RS08875
gene id: 1307761:L21SP2_RS08875
uniprot id: V5WJA7
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS04730
gene id: 1307761:L21SP2_RS04730
uniprot id: V5WF51
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1307761:L21SP2 RS03715
gene id: 1307761:L21SP2_RS03715
uniprot id: V5WF08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1307761:L21SP2 RS02000
gene id: 1307761:L21SP2_RS02000
uniprot id: V5WDE8
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1307761:L21SP2 RS16710
gene id: 1307761:L21SP2_RS16710
uniprot id: V5WE16
names: Similarity
messages: Belongs to the peptidase S49 family.

1307761:L21SP2 RS16400
gene id: 1307761:L21SP2_RS16400
uniprot id: V5WLJ5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1307761:L21SP2 RS12775
gene id: 1307761:L21SP2_RS12775
uniprot id: V5WKJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1307761:L21SP2 RS07875
gene id: 1307761:L21SP2_RS07875
uniprot id: V5WH01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1307761:L21SP2 RS00830
gene id: 1307761:L21SP2_RS00830
uniprot id: V5WEM6
names: Similarity
messages: Belongs to the arginine deiminase family.

1307761:L21SP2 RS04110
gene id: 1307761:L21SP2_RS04110
uniprot id: V5WEQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1307761:L21SP2 RS10205
gene id: 1307761:L21SP2_RS10205
uniprot id: V5WIT7
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1307761:L21SP2 RS11515
gene id: 1307761:L21SP2_RS11515
uniprot id: V5WIX5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS11235
gene id: 1307761:L21SP2_RS11235
uniprot id: V5WJB7
names: Similarity
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

1307761:L21SP2 RS09965
gene id: 1307761:L21SP2_RS09965
uniprot id: V5WIL7
names: Similarity
messages: Belongs to the citrate synthase family.

1307761:L21SP2 RS01300
gene id: 1307761:L21SP2_RS01300
uniprot id: V5WDS1
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1307761:L21SP2 RS15240
gene id: 1307761:L21SP2_RS15240
uniprot id: V5WLT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

1307761:L21SP2 RS04350
gene id: 1307761:L21SP2_RS04350
uniprot id: V5WEV9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307761:L21SP2 RS02325
gene id: 1307761:L21SP2_RS02325
uniprot id: V5WE48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1307761:L21SP2 RS10465
gene id: 1307761:L21SP2_RS10465
uniprot id: V5WID5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1307761:L21SP2 RS00170
gene id: 1307761:L21SP2_RS00170
uniprot id: V5WCH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS00010
gene id: 1307761:L21SP2_RS00010
uniprot id: V5WCD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1307761:L21SP2 RS13450
gene id: 1307761:L21SP2_RS13450
uniprot id: V5WKN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1307761:L21SP2 RS01900
gene id: 1307761:L21SP2_RS01900
uniprot id: V5WDX1
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS15810
gene id: 1307761:L21SP2_RS15810
uniprot id: V5WM38
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1307761:L21SP2 RS17520
gene id: 1307761:L21SP2_RS17520
uniprot id: V5WK62
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS01585
gene id: 1307761:L21SP2_RS01585
uniprot id: V5WDX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1307761:L21SP2 RS14955
gene id: 1307761:L21SP2_RS14955
uniprot id: V5WLP1
names: Similarity
messages: Belongs to the hemerythrin family.

1307761:L21SP2 RS07495
gene id: 1307761:L21SP2_RS07495
uniprot id: V5WH78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1307761:L21SP2 RS13290
gene id: 1307761:L21SP2_RS13290
uniprot id: V5WK30
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1307761:L21SP2 RS02345
gene id: 1307761:L21SP2_RS02345
uniprot id: V5WE54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1307761:L21SP2 RS11190
gene id: 1307761:L21SP2_RS11190
uniprot id: V5WKK0
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

1307761:L21SP2 RS02810
gene id: 1307761:L21SP2_RS02810
uniprot id: V5WE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1307761:L21SP2 RS11355
gene id: 1307761:L21SP2_RS11355
uniprot id: V5WJE7
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1307761:L21SP2 RS15110
gene id: 1307761:L21SP2_RS15110
uniprot id: V5WL69
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1307761:L21SP2 RS01975
gene id: 1307761:L21SP2_RS01975
uniprot id: V5WDH6
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1307761:L21SP2 RS01450
gene id: 1307761:L21SP2_RS01450
uniprot id: V5WD68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1307761:L21SP2 RS15170
gene id: 1307761:L21SP2_RS15170
uniprot id: V5WN25
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1307761:L21SP2 RS00245
gene id: 1307761:L21SP2_RS00245
uniprot id: V5WCJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1307761:L21SP2 RS08230
gene id: 1307761:L21SP2_RS08230
uniprot id: V5WH59
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1307761:L21SP2 RS08040
gene id: 1307761:L21SP2_RS08040
uniprot id: V5WHT1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1307761:L21SP2 RS02675
gene id: 1307761:L21SP2_RS02675
uniprot id: V5WDX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1307761:L21SP2 RS00620
gene id: 1307761:L21SP2_RS00620
uniprot id: V5WCQ2
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1307761:L21SP2 RS00390
gene id: 1307761:L21SP2_RS00390
uniprot id: V5WCN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS09625
gene id: 1307761:L21SP2_RS09625
uniprot id: V5WHU2
names: Similarity
messages: Belongs to the DEAD box helicase family.

1307761:L21SP2 RS00745
gene id: 1307761:L21SP2_RS00745
uniprot id: V5WDG9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1307761:L21SP2 RS14500
gene id: 1307761:L21SP2_RS14500
uniprot id: V5WL05
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1307761:L21SP2 RS13645
gene id: 1307761:L21SP2_RS13645
uniprot id: V5WM84
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1307761:L21SP2 RS05905
gene id: 1307761:L21SP2_RS05905
uniprot id: V5WFR5
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1307761:L21SP2 RS05040
gene id: 1307761:L21SP2_RS05040
uniprot id: V5WFB7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1307761:L21SP2 RS15000
gene id: 1307761:L21SP2_RS15000
uniprot id: V5WMZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

1307761:L21SP2 RS13385
gene id: 1307761:L21SP2_RS13385
uniprot id: V5WKM0
names: Subcellular Location Annotation
messages: Nucleus

1307761:L21SP2 RS12780
gene id: 1307761:L21SP2_RS12780
uniprot id: V5WKA6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1307761:L21SP2 RS08580
gene id: 1307761:L21SP2_RS08580
uniprot id: V5WHU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1307761:L21SP2 RS06670
gene id: 1307761:L21SP2_RS06670
uniprot id: V5WGR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1307761:L21SP2 RS14745
gene id: 1307761:L21SP2_RS14745
uniprot id: V5WMR5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1307761:L21SP2 RS13735
gene id: 1307761:L21SP2_RS13735
uniprot id: V5WM98
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS09440
gene id: 1307761:L21SP2_RS09440
uniprot id: V5WIG6
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1307761:L21SP2 RS16185
gene id: 1307761:L21SP2_RS16185
uniprot id: V5WNF5
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS00530
gene id: 1307761:L21SP2_RS00530
uniprot id: V5WCN6
names: Similarity
messages: Belongs to the peptidase A24 family.

1307761:L21SP2 RS08705
gene id: 1307761:L21SP2_RS08705
uniprot id: V5WI47
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1307761:L21SP2 RS17600
gene id: 1307761:L21SP2_RS17600
uniprot id: V5WLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS03710
gene id: 1307761:L21SP2_RS03710
uniprot id: V5WF96
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1307761:L21SP2 RS00270
gene id: 1307761:L21SP2_RS00270
uniprot id: V5WCK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1307761:L21SP2 RS07905
gene id: 1307761:L21SP2_RS07905
uniprot id: V5WIT5
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1307761:L21SP2 RS02520
gene id: 1307761:L21SP2_RS02520
uniprot id: V5WE94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS02175
gene id: 1307761:L21SP2_RS02175
uniprot id: V5WE86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1307761:L21SP2 RS16745
gene id: 1307761:L21SP2_RS16745
uniprot id: V5WFK3
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

1307761:L21SP2 RS11165
gene id: 1307761:L21SP2_RS11165
uniprot id: V5WKJ4
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1307761:L21SP2 RS02235
gene id: 1307761:L21SP2_RS02235
uniprot id: V5WDN5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1307761:L21SP2 RS13965
gene id: 1307761:L21SP2_RS13965
uniprot id: V5WKP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

1307761:L21SP2 RS07890
gene id: 1307761:L21SP2_RS07890
uniprot id: V5WIT1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1307761:L21SP2 RS17125
gene id: 1307761:L21SP2_RS17125
uniprot id: V5WHQ1
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1307761:L21SP2 RS08535
gene id: 1307761:L21SP2_RS08535
uniprot id: V5WJ35
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS13720
gene id: 1307761:L21SP2_RS13720
uniprot id: V5WKI5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1307761:L21SP2 RS03040
gene id: 1307761:L21SP2_RS03040
uniprot id: V5WFZ4
names: Similarity
messages: Belongs to the peptidase C15 family.

1307761:L21SP2 RS08640
gene id: 1307761:L21SP2_RS08640
uniprot id: V5WI33
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

1307761:L21SP2 RS00775
gene id: 1307761:L21SP2_RS00775
uniprot id: V5WDC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1307761:L21SP2 RS16445
gene id: 1307761:L21SP2_RS16445
uniprot id: V5WMF5
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1307761:L21SP2 RS06735
gene id: 1307761:L21SP2_RS06735
uniprot id: V5WGZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1307761:L21SP2 RS08390
gene id: 1307761:L21SP2_RS08390
uniprot id: V5WH80
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

1307761:L21SP2 RS15930
gene id: 1307761:L21SP2_RS15930
uniprot id: V5WLG2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1307761:L21SP2 RS07100
gene id: 1307761:L21SP2_RS07100
uniprot id: V5WGZ5
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS12475
gene id: 1307761:L21SP2_RS12475
uniprot id: V5WJK0
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

1307761:L21SP2 RS05375
gene id: 1307761:L21SP2_RS05375
uniprot id: V5WFJ9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1307761:L21SP2 RS09065
gene id: 1307761:L21SP2_RS09065
uniprot id: V5WI40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1307761:L21SP2 RS05585
gene id: 1307761:L21SP2_RS05585
uniprot id: V5WGC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1307761:L21SP2 RS12715
gene id: 1307761:L21SP2_RS12715
uniprot id: V5WLT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1307761:L21SP2 RS06785
gene id: 1307761:L21SP2_RS06785
uniprot id: V5WH04
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

1307761:L21SP2 RS09415
gene id: 1307761:L21SP2_RS09415
uniprot id: V5WIG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1307761:L21SP2 RS12725
gene id: 1307761:L21SP2_RS12725
uniprot id: V5WJY7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1307761:L21SP2 RS04455
gene id: 1307761:L21SP2_RS04455
uniprot id: V5WGT0
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1307761:L21SP2 RS04155
gene id: 1307761:L21SP2_RS04155
uniprot id: V5WES5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1307761:L21SP2 RS01575
gene id: 1307761:L21SP2_RS01575
uniprot id: V5WD93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

1307761:L21SP2 RS02890
gene id: 1307761:L21SP2_RS02890
uniprot id: V5WE23
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1307761:L21SP2 RS05495
gene id: 1307761:L21SP2_RS05495
uniprot id: V5WGA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1307761:L21SP2 RS02265
gene id: 1307761:L21SP2_RS02265
uniprot id: V5WDL4
names: Similarity
messages: Belongs to the WrbA family.

1307761:L21SP2 RS08985
gene id: 1307761:L21SP2_RS08985
uniprot id: V5WI26
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1307761:L21SP2 RS06485
gene id: 1307761:L21SP2_RS06485
uniprot id: V5WGM8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1307761:L21SP2 RS02425
gene id: 1307761:L21SP2_RS02425
uniprot id: V5WEE7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1307761:L21SP2 RS08220
gene id: 1307761:L21SP2_RS08220
uniprot id: V5WIY3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1307761:L21SP2 RS07285
gene id: 1307761:L21SP2_RS07285
uniprot id: V5WH35
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

1307761:L21SP2 RS14140
gene id: 1307761:L21SP2_RS14140
uniprot id: V5WKT0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1307761:L21SP2 RS03770
gene id: 1307761:L21SP2_RS03770
uniprot id: V5WEJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS17725
gene id: 1307761:L21SP2_RS17725
uniprot id: V5WM99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1307761:L21SP2 RS10440
gene id: 1307761:L21SP2_RS10440
uniprot id: V5WIC9
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1307761:L21SP2 RS12880
gene id: 1307761:L21SP2_RS12880
uniprot id: V5WKL2
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1307761:L21SP2 RS04305
gene id: 1307761:L21SP2_RS04305
uniprot id: V5WFK5
names: Similarity
messages: Belongs to the aspartokinase family.

1307761:L21SP2 RS08925
gene id: 1307761:L21SP2_RS08925
uniprot id: V5WHF1
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1307761:L21SP2 RS13150
gene id: 1307761:L21SP2_RS13150
uniprot id: V5WKR7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1307761:L21SP2 RS14615
gene id: 1307761:L21SP2_RS14615
uniprot id: V5WLC0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS13440
gene id: 1307761:L21SP2_RS13440
uniprot id: V5WKC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS15455
gene id: 1307761:L21SP2_RS15455
uniprot id: V5WLW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1307761:L21SP2 RS11525
gene id: 1307761:L21SP2_RS11525
uniprot id: V5WJP2
names: Similarity
messages: Belongs to the UPF0178 family.

1307761:L21SP2 RS06335
gene id: 1307761:L21SP2_RS06335
uniprot id: V5WGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1307761:L21SP2 RS13880
gene id: 1307761:L21SP2_RS13880
uniprot id: V5WKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS16105
gene id: 1307761:L21SP2_RS16105
uniprot id: V5WM93
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS12990
gene id: 1307761:L21SP2_RS12990
uniprot id: V5WLY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1307761:L21SP2 RS06710
gene id: 1307761:L21SP2_RS06710
uniprot id: V5WG58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1307761:L21SP2 RS12755
gene id: 1307761:L21SP2_RS12755
uniprot id: V5WKA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1307761:L21SP2 RS09275
gene id: 1307761:L21SP2_RS09275
uniprot id: V5WJI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

1307761:L21SP2 RS13270
gene id: 1307761:L21SP2_RS13270
uniprot id: V5WK86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1307761:L21SP2 RS04135
gene id: 1307761:L21SP2_RS04135
uniprot id: V5WER3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1307761:L21SP2 RS01815
gene id: 1307761:L21SP2_RS01815
uniprot id: V5WDW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS16050
gene id: 1307761:L21SP2_RS16050
uniprot id: V5WNT1
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS13500
gene id: 1307761:L21SP2_RS13500
uniprot id: V5WKP3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1307761:L21SP2 RS16505
gene id: 1307761:L21SP2_RS16505
uniprot id: V5WLJ9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1307761:L21SP2 RS11580
gene id: 1307761:L21SP2_RS11580
uniprot id: V5WIZ0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1307761:L21SP2 RS16480
gene id: 1307761:L21SP2_RS16480
uniprot id: V5WLJ8
names: Similarity
messages: Belongs to the ParB family.

1307761:L21SP2 RS10125
gene id: 1307761:L21SP2_RS10125
uniprot id: V5WK18
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

1307761:L21SP2 RS15520
gene id: 1307761:L21SP2_RS15520
uniprot id: V5WNP0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS08365
gene id: 1307761:L21SP2_RS08365
uniprot id: V5WH76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1307761:L21SP2 RS15020
gene id: 1307761:L21SP2_RS15020
uniprot id: V5WLQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1307761:L21SP2 RS04345
gene id: 1307761:L21SP2_RS04345
uniprot id: V5WEX2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307761:L21SP2 RS15860
gene id: 1307761:L21SP2_RS15860
uniprot id: V5WM46
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1307761:L21SP2 RS04140
gene id: 1307761:L21SP2_RS04140
uniprot id: V5WFH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1307761:L21SP2 RS03630
gene id: 1307761:L21SP2_RS03630
uniprot id: V5WGA8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1307761:L21SP2 RS08635
gene id: 1307761:L21SP2_RS08635
uniprot id: V5WHB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1307761:L21SP2 RS09155
gene id: 1307761:L21SP2_RS09155
uniprot id: V5WI52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1307761:L21SP2 RS16065
gene id: 1307761:L21SP2_RS16065
uniprot id: V5WND3
names: Similarity
messages: Belongs to the photoactive yellow protein family.

1307761:L21SP2 RS10340
gene id: 1307761:L21SP2_RS10340
uniprot id: V5WJ37
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS17445
gene id: 1307761:L21SP2_RS17445
uniprot id: V5WJL6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1307761:L21SP2 RS09510
gene id: 1307761:L21SP2_RS09510
uniprot id: V5WII3
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS11260
gene id: 1307761:L21SP2_RS11260
uniprot id: V5WKL6
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05465
gene id: 1307761:L21SP2_RS05465
uniprot id: V5WFI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1307761:L21SP2 RS16285
gene id: 1307761:L21SP2_RS16285
uniprot id: V5WMB8
names: Similarity
messages: Belongs to the ArsC family.

1307761:L21SP2 RS05505
gene id: 1307761:L21SP2_RS05505
uniprot id: V5WHD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1307761:L21SP2 RS03440
gene id: 1307761:L21SP2_RS03440
uniprot id: V5WED2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

1307761:L21SP2 RS00965
gene id: 1307761:L21SP2_RS00965
uniprot id: V5WCX7
names: Similarity
messages: Belongs to the thioredoxin family.

1307761:L21SP2 RS04340
gene id: 1307761:L21SP2_RS04340
uniprot id: V5WGR1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1307761:L21SP2 RS08615
gene id: 1307761:L21SP2_RS08615
uniprot id: V5WI28
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1307761:L21SP2 RS11925
gene id: 1307761:L21SP2_RS11925
uniprot id: V5WJC2
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

1307761:L21SP2 RS17030
gene id: 1307761:L21SP2_RS17030
uniprot id: V5WI49
names: Similarity
messages: Belongs to the PTH family.

1307761:L21SP2 RS05265
gene id: 1307761:L21SP2_RS05265
uniprot id: V5WFZ9
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1307761:L21SP2 RS07130
gene id: 1307761:L21SP2_RS07130
uniprot id: V5WIB2
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1307761:L21SP2 RS08395
gene id: 1307761:L21SP2_RS08395
uniprot id: V5WHY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

1307761:L21SP2 RS13225
gene id: 1307761:L21SP2_RS13225
uniprot id: V5WK75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS13105
gene id: 1307761:L21SP2_RS13105
uniprot id: V5WKF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

1307761:L21SP2 RS10065
gene id: 1307761:L21SP2_RS10065
uniprot id: V5WI74
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

1307761:L21SP2 RS08180
gene id: 1307761:L21SP2_RS08180
uniprot id: V5WH49
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1307761:L21SP2 RS10375
gene id: 1307761:L21SP2_RS10375
uniprot id: V5WIB7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1307761:L21SP2 RS13565
gene id: 1307761:L21SP2_RS13565
uniprot id: V5WKQ8
names: Similarity
messages: Belongs to the MEMO1 family.

1307761:L21SP2 RS09420
gene id: 1307761:L21SP2_RS09420
uniprot id: V5WI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1307761:L21SP2 RS02010
gene id: 1307761:L21SP2_RS02010
uniprot id: V5WDY9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1307761:L21SP2 RS07715
gene id: 1307761:L21SP2_RS07715
uniprot id: V5WGX5
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

1307761:L21SP2 RS15250
gene id: 1307761:L21SP2_RS15250
uniprot id: V5WLV3
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1307761:L21SP2 RS08440
gene id: 1307761:L21SP2_RS08440
uniprot id: V5WH88
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

1307761:L21SP2 RS13520
gene id: 1307761:L21SP2_RS13520
uniprot id: V5WKP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1307761:L21SP2 RS00195
gene id: 1307761:L21SP2_RS00195
uniprot id: V5WCH6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1307761:L21SP2 RS16170
gene id: 1307761:L21SP2_RS16170
uniprot id: V5WLH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1307761:L21SP2 RS07720
gene id: 1307761:L21SP2_RS07720
uniprot id: V5WHM6
names: Similarity
messages: Belongs to the RecJ family.

1307761:L21SP2 RS13030
gene id: 1307761:L21SP2_RS13030
uniprot id: V5WKE2
names: Similarity
messages: Belongs to the glycosyl hydrolase.

1307761:L21SP2 RS13995
gene id: 1307761:L21SP2_RS13995
uniprot id: V5WL82
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1307761:L21SP2 RS07550
gene id: 1307761:L21SP2_RS07550
uniprot id: V5WH91
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

1307761:L21SP2 RS01240
gene id: 1307761:L21SP2_RS01240
uniprot id: V5WEV5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS08385
gene id: 1307761:L21SP2_RS08385
uniprot id: V5WH53
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS05880
gene id: 1307761:L21SP2_RS05880
uniprot id: V5WFR2
names: Subcellular Location Annotation
messages: Periplasmic flagellum

1307761:L21SP2 RS13330
gene id: 1307761:L21SP2_RS13330
uniprot id: V5WKW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1307761:L21SP2 RS09280
gene id: 1307761:L21SP2_RS09280
uniprot id: V5WHL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS09400
gene id: 1307761:L21SP2_RS09400
uniprot id: V5WJK7
names: Similarity
messages: Belongs to the Nth/MutY family.

1307761:L21SP2 RS08820
gene id: 1307761:L21SP2_RS08820
uniprot id: V5WHZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1307761:L21SP2 RS15815
gene id: 1307761:L21SP2_RS15815
uniprot id: V5WNA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS12595
gene id: 1307761:L21SP2_RS12595
uniprot id: V5WJR2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1307761:L21SP2 RS01935
gene id: 1307761:L21SP2_RS01935
uniprot id: V5WDD2
names: Caution
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS11830
gene id: 1307761:L21SP2_RS11830
uniprot id: V5WKY6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1307761:L21SP2 RS05605
gene id: 1307761:L21SP2_RS05605
uniprot id: V5WFP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1307761:L21SP2 RS05560
gene id: 1307761:L21SP2_RS05560
uniprot id: V5WGB8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1307761:L21SP2 RS09850
gene id: 1307761:L21SP2_RS09850
uniprot id: V5WIQ1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1307761:L21SP2 RS06500
gene id: 1307761:L21SP2_RS06500
uniprot id: V5WGN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1307761:L21SP2 RS10850
gene id: 1307761:L21SP2_RS10850
uniprot id: V5WKC8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1307761:L21SP2 RS15915
gene id: 1307761:L21SP2_RS15915
uniprot id: V5WNB6
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1307761:L21SP2 RS02560
gene id: 1307761:L21SP2_RS02560
uniprot id: V5WDV4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1307761:L21SP2 RS10490
gene id: 1307761:L21SP2_RS10490
uniprot id: V5WIE0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS14010
gene id: 1307761:L21SP2_RS14010
uniprot id: V5WKP9
names: Similarity
messages: Belongs to the peptidase M24B family.

1307761:L21SP2 RS11860
gene id: 1307761:L21SP2_RS11860
uniprot id: V5WJ49
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1307761:L21SP2 RS02440
gene id: 1307761:L21SP2_RS02440
uniprot id: V5WDS8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1307761:L21SP2 RS08470
gene id: 1307761:L21SP2_RS08470
uniprot id: V5WHZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1307761:L21SP2 RS15830
gene id: 1307761:L21SP2_RS15830
uniprot id: V5WLF3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1307761:L21SP2 RS08575
gene id: 1307761:L21SP2_RS08575
uniprot id: V5WI18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1307761:L21SP2 RS15855
gene id: 1307761:L21SP2_RS15855
uniprot id: V5WLF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1307761:L21SP2 RS02230
gene id: 1307761:L21SP2_RS02230
uniprot id: V5WFD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1307761:L21SP2 RS05200
gene id: 1307761:L21SP2_RS05200
uniprot id: V5WG53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1307761:L21SP2 RS12655
gene id: 1307761:L21SP2_RS12655
uniprot id: V5WK85
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS00585
gene id: 1307761:L21SP2_RS00585
uniprot id: V5WDE0
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS07205
gene id: 1307761:L21SP2_RS07205
uniprot id: V5WGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS03225
gene id: 1307761:L21SP2_RS03225
uniprot id: V5WE92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS11230
gene id: 1307761:L21SP2_RS11230
uniprot id: V5WJJ2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1307761:L21SP2 RS10390
gene id: 1307761:L21SP2_RS10390
uniprot id: V5WK55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1307761:L21SP2 RS15685
gene id: 1307761:L21SP2_RS15685
uniprot id: V5WNQ2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

1307761:L21SP2 RS15330
gene id: 1307761:L21SP2_RS15330
uniprot id: V5WLA2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1307761:L21SP2 RS04830
gene id: 1307761:L21SP2_RS04830
uniprot id: V5WH03
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1307761:L21SP2 RS00005
gene id: 1307761:L21SP2_RS00005
uniprot id: V5WCD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1307761:L21SP2 RS11820
gene id: 1307761:L21SP2_RS11820
uniprot id: V5WJT9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1307761:L21SP2 RS01085
gene id: 1307761:L21SP2_RS01085
uniprot id: V5WDI1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS12760
gene id: 1307761:L21SP2_RS12760
uniprot id: V5WLV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1307761:L21SP2 RS13535
gene id: 1307761:L21SP2_RS13535
uniprot id: V5WKE3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1307761:L21SP2 RS06480
gene id: 1307761:L21SP2_RS06480
uniprot id: V5WGT8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS08175
gene id: 1307761:L21SP2_RS08175
uniprot id: V5WH15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1307761:L21SP2 RS02530
gene id: 1307761:L21SP2_RS02530
uniprot id: V5WDU9
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1307761:L21SP2 RS00905
gene id: 1307761:L21SP2_RS00905
uniprot id: V5WEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS14725
gene id: 1307761:L21SP2_RS14725
uniprot id: V5WKX4
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1307761:L21SP2 RS06220
gene id: 1307761:L21SP2_RS06220
uniprot id: V5WG06
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1307761:L21SP2 RS04120
gene id: 1307761:L21SP2_RS04120
uniprot id: V5WF90
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1307761:L21SP2 RS12750
gene id: 1307761:L21SP2_RS12750
uniprot id: V5WJZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1307761:L21SP2 RS08265
gene id: 1307761:L21SP2_RS08265
uniprot id: V5WH34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1307761:L21SP2 RS15210
gene id: 1307761:L21SP2_RS15210
uniprot id: V5WL88
names: Similarity
messages: Belongs to the hemerythrin family.

1307761:L21SP2 RS00955
gene id: 1307761:L21SP2_RS00955
uniprot id: V5WDF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1307761:L21SP2 RS03980
gene id: 1307761:L21SP2_RS03980
uniprot id: V5WFE0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1307761:L21SP2 RS06555
gene id: 1307761:L21SP2_RS06555
uniprot id: V5WI00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307761:L21SP2 RS14710
gene id: 1307761:L21SP2_RS14710
uniprot id: V5WLI4
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS01870
gene id: 1307761:L21SP2_RS01870
uniprot id: V5WE10
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1307761:L21SP2 RS04705
gene id: 1307761:L21SP2_RS04705
uniprot id: V5WF44
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

1307761:L21SP2 RS02570
gene id: 1307761:L21SP2_RS02570
uniprot id: V5WFM2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1307761:L21SP2 RS08600
gene id: 1307761:L21SP2_RS08600
uniprot id: V5WJ52
names: Similarity
messages: Belongs to the Skp family.

1307761:L21SP2 RS15750
gene id: 1307761:L21SP2_RS15750
uniprot id: V5WN95
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1307761:L21SP2 RS16085
gene id: 1307761:L21SP2_RS16085
uniprot id: V5WND6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS00060
gene id: 1307761:L21SP2_RS00060
uniprot id: V5WD14
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

1307761:L21SP2 RS17480
gene id: 1307761:L21SP2_RS17480
uniprot id: V5WJX1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

1307761:L21SP2 RS03220
gene id: 1307761:L21SP2_RS03220
uniprot id: V5WE98
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1307761:L21SP2 RS12325
gene id: 1307761:L21SP2_RS12325
uniprot id: V5WJX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1307761:L21SP2 RS10370
gene id: 1307761:L21SP2_RS10370
uniprot id: V5WK53
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307761:L21SP2 RS11470
gene id: 1307761:L21SP2_RS11470
uniprot id: V5WJ14
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1307761:L21SP2 RS08310
gene id: 1307761:L21SP2_RS08310
uniprot id: V5WHP4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1307761:L21SP2 RS08645
gene id: 1307761:L21SP2_RS08645
uniprot id: V5WHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1307761:L21SP2 RS17370
gene id: 1307761:L21SP2_RS17370
uniprot id: V5WKL0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1307761:L21SP2 RS00345
gene id: 1307761:L21SP2_RS00345
uniprot id: V5WCL0
names: Similarity
messages: Belongs to the aspartokinase family.

1307761:L21SP2 RS06070
gene id: 1307761:L21SP2_RS06070
uniprot id: V5WGE7
names: Similarity
messages: Belongs to the universal stress protein A family.

1307761:L21SP2 RS09975
gene id: 1307761:L21SP2_RS09975
uniprot id: V5WI16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

1307761:L21SP2 RS12220
gene id: 1307761:L21SP2_RS12220
uniprot id: V5WL70
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1307761:L21SP2 RS06650
gene id: 1307761:L21SP2_RS06650
uniprot id: V5WI20
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1307761:L21SP2 RS09795
gene id: 1307761:L21SP2_RS09795
uniprot id: V5WHX7
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1307761:L21SP2 RS12830
gene id: 1307761:L21SP2_RS12830
uniprot id: V5WK05
names: Similarity
messages: Belongs to the fructosamine kinase family.

1307761:L21SP2 RS05020
gene id: 1307761:L21SP2_RS05020
uniprot id: V5WFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS08895
gene id: 1307761:L21SP2_RS08895
uniprot id: V5WI08
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

1307761:L21SP2 RS06395
gene id: 1307761:L21SP2_RS06395
uniprot id: V5WHW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1307761:L21SP2 RS17560
gene id: 1307761:L21SP2_RS17560
uniprot id: V5WMC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMG-CoA reductase family.
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS07435
gene id: 1307761:L21SP2_RS07435
uniprot id: V5WII0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1307761:L21SP2 RS04105
gene id: 1307761:L21SP2_RS04105
uniprot id: V5WER4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1307761:L21SP2 RS07380
gene id: 1307761:L21SP2_RS07380
uniprot id: V5WHC8
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS06210
gene id: 1307761:L21SP2_RS06210
uniprot id: V5WHS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1307761:L21SP2 RS00240
gene id: 1307761:L21SP2_RS00240
uniprot id: V5WCI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1307761:L21SP2 RS04935
gene id: 1307761:L21SP2_RS04935
uniprot id: V5WH24
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1307761:L21SP2 RS00135
gene id: 1307761:L21SP2_RS00135
uniprot id: V5WCZ5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1307761:L21SP2 RS05620
gene id: 1307761:L21SP2_RS05620
uniprot id: V5WHG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1307761:L21SP2 RS07610
gene id: 1307761:L21SP2_RS07610
uniprot id: V5WIM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
messages: Monomer.

1307761:L21SP2 RS10425
gene id: 1307761:L21SP2_RS10425
uniprot id: V5WJ53
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1307761:L21SP2 RS12845
gene id: 1307761:L21SP2_RS12845
uniprot id: V5WLW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1307761:L21SP2 RS02245
gene id: 1307761:L21SP2_RS02245
uniprot id: V5WEA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1307761:L21SP2 RS10020
gene id: 1307761:L21SP2_RS10020
uniprot id: V5WI64
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1307761:L21SP2 RS07295
gene id: 1307761:L21SP2_RS07295
uniprot id: V5WGI2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS06745
gene id: 1307761:L21SP2_RS06745
uniprot id: V5WI41
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1307761:L21SP2 RS03475
gene id: 1307761:L21SP2_RS03475
uniprot id: V5WF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS15970
gene id: 1307761:L21SP2_RS15970
uniprot id: V5WM89
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1307761:L21SP2 RS10555
gene id: 1307761:L21SP2_RS10555
uniprot id: V5WJ77
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1307761:L21SP2 RS01440
gene id: 1307761:L21SP2_RS01440
uniprot id: V5WDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1307761:L21SP2 RS09980
gene id: 1307761:L21SP2_RS09980
uniprot id: V5WI55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1307761:L21SP2 RS00730
gene id: 1307761:L21SP2_RS00730
uniprot id: V5WDC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1307761:L21SP2 RS03620
gene id: 1307761:L21SP2_RS03620
uniprot id: V5WF78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1307761:L21SP2 RS11005
gene id: 1307761:L21SP2_RS11005
uniprot id: V5WKF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1307761:L21SP2 RS02165
gene id: 1307761:L21SP2_RS02165
uniprot id: V5WDM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1307761:L21SP2 RS13405
gene id: 1307761:L21SP2_RS13405
uniprot id: V5WKX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1307761:L21SP2 RS12770
gene id: 1307761:L21SP2_RS12770
uniprot id: V5WJZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1307761:L21SP2 RS07765
gene id: 1307761:L21SP2_RS07765
uniprot id: V5WHN6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1307761:L21SP2 RS15555
gene id: 1307761:L21SP2_RS15555
uniprot id: V5WN71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

1307761:L21SP2 RS01215
gene id: 1307761:L21SP2_RS01215
uniprot id: V5WDK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1307761:L21SP2 RS03740
gene id: 1307761:L21SP2_RS03740
uniprot id: V5WGD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1307761:L21SP2 RS13730
gene id: 1307761:L21SP2_RS13730
uniprot id: V5WKU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1307761:L21SP2 RS14205
gene id: 1307761:L21SP2_RS14205
uniprot id: V5WKL7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1307761:L21SP2 RS03655
gene id: 1307761:L21SP2_RS03655
uniprot id: V5WGB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1307761:L21SP2 RS02410
gene id: 1307761:L21SP2_RS02410
uniprot id: V5WE70
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1307761:L21SP2 RS10980
gene id: 1307761:L21SP2_RS10980
uniprot id: V5WKF5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1307761:L21SP2 RS14080
gene id: 1307761:L21SP2_RS14080
uniprot id: V5WMG5
names: Similarity
messages: Belongs to the Fur family.

1307761:L21SP2 RS10105
gene id: 1307761:L21SP2_RS10105
uniprot id: V5WI57
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1307761:L21SP2 RS07850
gene id: 1307761:L21SP2_RS07850
uniprot id: V5WHP7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1307761:L21SP2 RS10525
gene id: 1307761:L21SP2_RS10525
uniprot id: V5WJ71
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS00750
gene id: 1307761:L21SP2_RS00750
uniprot id: V5WDC4
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS05320
gene id: 1307761:L21SP2_RS05320
uniprot id: V5WG08
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1307761:L21SP2 RS04385
gene id: 1307761:L21SP2_RS04385
uniprot id: V5WEX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

1307761:L21SP2 RS02365
gene id: 1307761:L21SP2_RS02365
uniprot id: V5WED1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1307761:L21SP2 RS06120
gene id: 1307761:L21SP2_RS06120
uniprot id: V5WHQ9
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS17755
gene id: 1307761:L21SP2_RS17755
uniprot id: V5WLJ1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1307761:L21SP2 RS09260
gene id: 1307761:L21SP2_RS09260
uniprot id: V5WHL4
names: Subcellular Location Annotation
messages: Membrane

1307761:L21SP2 RS09315
gene id: 1307761:L21SP2_RS09315
uniprot id: V5WID9
names: Similarity
messages: Belongs to the phosphohexose mutase family.