1306519:BIW12 RS02305
gene id: 1306519:BIW12_RS02305
uniprot id: A0A1D9P6Z7
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1306519:BIW12 RS12605
gene id: 1306519:BIW12_RS12605
uniprot id: A0A1D9PC87
names: Similarity
messages: Belongs to the threonine aldolase family.

1306519:BIW12 RS02190
gene id: 1306519:BIW12_RS02190
uniprot id: A0A1D9P735
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1306519:BIW12 RS11740
gene id: 1306519:BIW12_RS11740
uniprot id: A0A1D9PD54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

1306519:BIW12 RS00925
gene id: 1306519:BIW12_RS00925
uniprot id: A0A1D9P730
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

1306519:BIW12 RS10195
gene id: 1306519:BIW12_RS10195
uniprot id: A0A1D9PB37
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS03850
gene id: 1306519:BIW12_RS03850
uniprot id: A0A1D9P7V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1306519:BIW12 RS13530
gene id: 1306519:BIW12_RS13530
uniprot id: A0A1D9PCU9
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1306519:BIW12 RS08710
gene id: 1306519:BIW12_RS08710
uniprot id: A0A1D9PAC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1306519:BIW12 RS05515
gene id: 1306519:BIW12_RS05515
uniprot id: A0A1D9P8N7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS10960
gene id: 1306519:BIW12_RS10960
uniprot id: A0A1D9PBF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1306519:BIW12 RS10280
gene id: 1306519:BIW12_RS10280
uniprot id: A0A1D9PB58
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS13665
gene id: 1306519:BIW12_RS13665
uniprot id: A0A1D9PCW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1306519:BIW12 RS02185
gene id: 1306519:BIW12_RS02185
uniprot id: A0A1D9P6X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

1306519:BIW12 RS09770
gene id: 1306519:BIW12_RS09770
uniprot id: A0A1D9PAV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS07865
gene id: 1306519:BIW12_RS07865
uniprot id: A0A1D9PB86
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS11980
gene id: 1306519:BIW12_RS11980
uniprot id: A0A1D9PC41
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS09330
gene id: 1306519:BIW12_RS09330
uniprot id: A0A1D9PEG7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1306519:BIW12 RS13995
gene id: 1306519:BIW12_RS13995
uniprot id: A0A1D9PEL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1306519:BIW12 RS11005
gene id: 1306519:BIW12_RS11005
uniprot id: A0A1D9PBE8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1306519:BIW12 RS05290
gene id: 1306519:BIW12_RS05290
uniprot id: A0A1D9P8K6
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1306519:BIW12 RS06460
gene id: 1306519:BIW12_RS06460
uniprot id: A0A1D9P974
names: Similarity
messages: Belongs to the GARS family.

1306519:BIW12 RS03580
gene id: 1306519:BIW12_RS03580
uniprot id: A0A1D9P7M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1306519:BIW12 RS13630
gene id: 1306519:BIW12_RS13630
uniprot id: A0A1D9PCS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1306519:BIW12 RS02570
gene id: 1306519:BIW12_RS02570
uniprot id: A0A1D9P7B2
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

1306519:BIW12 RS15170
gene id: 1306519:BIW12_RS15170
uniprot id: A0A1D9PDT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1306519:BIW12 RS00780
gene id: 1306519:BIW12_RS00780
uniprot id: A0A1D9P641
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0187 family.
messages: Membrane

1306519:BIW12 RS15275
gene id: 1306519:BIW12_RS15275
uniprot id: A0A1D9PDV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1306519:BIW12 RS05230
gene id: 1306519:BIW12_RS05230
uniprot id: A0A1D9P9W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1306519:BIW12 RS02760
gene id: 1306519:BIW12_RS02760
uniprot id: A0A1D9P7B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS08765
gene id: 1306519:BIW12_RS08765
uniprot id: A0A1D9PBN2
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS09650
gene id: 1306519:BIW12_RS09650
uniprot id: A0A1D9PCM8
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS13620
gene id: 1306519:BIW12_RS13620
uniprot id: A0A1D9PDH3
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1306519:BIW12 RS07705
gene id: 1306519:BIW12_RS07705
uniprot id: A0A1D9PB61
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS03060
gene id: 1306519:BIW12_RS03060
uniprot id: A0A1D9P7D5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1306519:BIW12 RS05215
gene id: 1306519:BIW12_RS05215
uniprot id: A0A1D9P8N1
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1306519:BIW12 RS01860
gene id: 1306519:BIW12_RS01860
uniprot id: A0A1D9P838
names: Similarity
messages: Belongs to the TrpC family.

1306519:BIW12 RS13765
gene id: 1306519:BIW12_RS13765
uniprot id: A0A1D9PCS9
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS14390
gene id: 1306519:BIW12_RS14390
uniprot id: A0A1D9PDV8
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1306519:BIW12 RS14430
gene id: 1306519:BIW12_RS14430
uniprot id: A0A1D9PDB2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS00245
gene id: 1306519:BIW12_RS00245
uniprot id: A0A1D9P662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS10930
gene id: 1306519:BIW12_RS10930
uniprot id: A0A1D9PBC7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1306519:BIW12 RS05335
gene id: 1306519:BIW12_RS05335
uniprot id: A0A1D9P9D0
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS10560
gene id: 1306519:BIW12_RS10560
uniprot id: A0A1D9PB84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS02000
gene id: 1306519:BIW12_RS02000
uniprot id: A0A1D9P721
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1306519:BIW12 RS00785
gene id: 1306519:BIW12_RS00785
uniprot id: A0A1D9P670
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1306519:BIW12 RS04165
gene id: 1306519:BIW12_RS04165
uniprot id: A0A1D9P8R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS10495
gene id: 1306519:BIW12_RS10495
uniprot id: A0A1D9PB72
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

1306519:BIW12 RS06525
gene id: 1306519:BIW12_RS06525
uniprot id: A0A1D9P962
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1306519:BIW12 RS03595
gene id: 1306519:BIW12_RS03595
uniprot id: A0A1D9P7T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1306519:BIW12 RS09610
gene id: 1306519:BIW12_RS09610
uniprot id: A0A1D9PF60
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS11780
gene id: 1306519:BIW12_RS11780
uniprot id: A0A1D9PEI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1306519:BIW12 RS11135
gene id: 1306519:BIW12_RS11135
uniprot id: A0A1D9PC91
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1306519:BIW12 RS02780
gene id: 1306519:BIW12_RS02780
uniprot id: A0A1D9P7E8
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS00455
gene id: 1306519:BIW12_RS00455
uniprot id: A0A1D9P7Z0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS10200
gene id: 1306519:BIW12_RS10200
uniprot id: A0A1D9PB10
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS07235
gene id: 1306519:BIW12_RS07235
uniprot id: A0A1D9P9I8
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

1306519:BIW12 RS13255
gene id: 1306519:BIW12_RS13255
uniprot id: A0A1D9PCQ0
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS15030
gene id: 1306519:BIW12_RS15030
uniprot id: A0A1D9PDG8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1306519:BIW12 RS07640
gene id: 1306519:BIW12_RS07640
uniprot id: A0A1D9PAH2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1306519:BIW12 RS04160
gene id: 1306519:BIW12_RS04160
uniprot id: A0A1D9P810
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1306519:BIW12 RS02275
gene id: 1306519:BIW12_RS02275
uniprot id: A0A1D9P768
names: Similarity
messages: Belongs to the sterol desaturase family.

1306519:BIW12 RS08010
gene id: 1306519:BIW12_RS08010
uniprot id: A0A1D9P9Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1306519:BIW12 RS01245
gene id: 1306519:BIW12_RS01245
uniprot id: A0A1D9P6P3
names: Similarity
messages: Belongs to the BshC family.

1306519:BIW12 RS11020
gene id: 1306519:BIW12_RS11020
uniprot id: A0A1D9PBG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1306519:BIW12 RS02075
gene id: 1306519:BIW12_RS02075
uniprot id: A0A1D9P6V5
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

1306519:BIW12 RS09775
gene id: 1306519:BIW12_RS09775
uniprot id: A0A1D9PAZ5
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS06225
gene id: 1306519:BIW12_RS06225
uniprot id: A0A1D9P920
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS13650
gene id: 1306519:BIW12_RS13650
uniprot id: A0A1D9PCS6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1306519:BIW12 RS03000
gene id: 1306519:BIW12_RS03000
uniprot id: A0A1D9P7I7
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1306519:BIW12 RS04485
gene id: 1306519:BIW12_RS04485
uniprot id: A0A1D9P845
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1306519:BIW12 RS10725
gene id: 1306519:BIW12_RS10725
uniprot id: A0A1D9PCN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1306519:BIW12 RS07470
gene id: 1306519:BIW12_RS07470
uniprot id: A0A1D9P9P2
names: Similarity
messages: Belongs to the DinB family.

1306519:BIW12 RS07255
gene id: 1306519:BIW12_RS07255
uniprot id: A0A1D9PAA2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1306519:BIW12 RS06545
gene id: 1306519:BIW12_RS06545
uniprot id: A0A1D9P9A3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1306519:BIW12 RS05975
gene id: 1306519:BIW12_RS05975
uniprot id: A0A1D9P8X1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS00230
gene id: 1306519:BIW12_RS00230
uniprot id: A0A1D9P627
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1306519:BIW12 RS08670
gene id: 1306519:BIW12_RS08670
uniprot id: A0A1D9PAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS12780
gene id: 1306519:BIW12_RS12780
uniprot id: A0A1D9PCF2
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1306519:BIW12 RS12965
gene id: 1306519:BIW12_RS12965
uniprot id: A0A1D9PCG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

1306519:BIW12 RS11840
gene id: 1306519:BIW12_RS11840
uniprot id: A0A1D9PBW6
names: Similarity
messages: Belongs to the ParB family.

1306519:BIW12 RS12935
gene id: 1306519:BIW12_RS12935
uniprot id: A0A1D9PCL7
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

1306519:BIW12 RS04115
gene id: 1306519:BIW12_RS04115
uniprot id: A0A1D9P9A7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1306519:BIW12 RS00805
gene id: 1306519:BIW12_RS00805
uniprot id: A0A1D9P6A4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1306519:BIW12 RS01635
gene id: 1306519:BIW12_RS01635
uniprot id: A0A1D9P6W0
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1306519:BIW12 RS15545
gene id: 1306519:BIW12_RS15545
uniprot id: A0A1D9PE00
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1306519:BIW12 RS06600
gene id: 1306519:BIW12_RS06600
uniprot id: A0A1D9P989
names: Similarity
messages: Belongs to the Skp family.

1306519:BIW12 RS11940
gene id: 1306519:BIW12_RS11940
uniprot id: A0A1D9PC01
names: Similarity
messages: Belongs to the DinB family.

1306519:BIW12 RS02025
gene id: 1306519:BIW12_RS02025
uniprot id: A0A1D9P6U3
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS04380
gene id: 1306519:BIW12_RS04380
uniprot id: A0A1D9PE99
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1306519:BIW12 RS08560
gene id: 1306519:BIW12_RS08560
uniprot id: A0A1D9PA95
names: Similarity
messages: Belongs to the thioredoxin family.

1306519:BIW12 RS03600
gene id: 1306519:BIW12_RS03600
uniprot id: A0A1D9P8F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1306519:BIW12 RS06825
gene id: 1306519:BIW12_RS06825
uniprot id: A0A1D9P9E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1306519:BIW12 RS01065
gene id: 1306519:BIW12_RS01065
uniprot id: A0A1D9P6E9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1306519:BIW12 RS05125
gene id: 1306519:BIW12_RS05125
uniprot id: A0A1D9P990
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS09910
gene id: 1306519:BIW12_RS09910
uniprot id: A0A1D9PAX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1306519:BIW12 RS10935
gene id: 1306519:BIW12_RS10935
uniprot id: A0A1D9PBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1306519:BIW12 RS12170
gene id: 1306519:BIW12_RS12170
uniprot id: A0A1D9PC38
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS10035
gene id: 1306519:BIW12_RS10035
uniprot id: A0A1D9PB38
names: Subcellular Location Annotation
messages: Cytoplasm

1306519:BIW12 RS06540
gene id: 1306519:BIW12_RS06540
uniprot id: A0A1D9P970
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1306519:BIW12 RS15795
gene id: 1306519:BIW12_RS15795
uniprot id: A0A1D9PE12
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1306519:BIW12 RS11175
gene id: 1306519:BIW12_RS11175
uniprot id: A0A1D9PBN6
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS04020
gene id: 1306519:BIW12_RS04020
uniprot id: A0A1D9P7V8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1306519:BIW12 RS14240
gene id: 1306519:BIW12_RS14240
uniprot id: A0A1D9PDA1
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1306519:BIW12 RS09845
gene id: 1306519:BIW12_RS09845
uniprot id: A0A1D9PC75
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1306519:BIW12 RS03980
gene id: 1306519:BIW12_RS03980
uniprot id: A0A1D9P7U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1306519:BIW12 RS02935
gene id: 1306519:BIW12_RS02935
uniprot id: A0A1D9P7B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1306519:BIW12 RS13550
gene id: 1306519:BIW12_RS13550
uniprot id: A0A1D9PCR4
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

1306519:BIW12 RS14335
gene id: 1306519:BIW12_RS14335
uniprot id: A0A1D9PEE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS11045
gene id: 1306519:BIW12_RS11045
uniprot id: A0A1D9PBG1
names: Similarity
messages: Belongs to the peptidase C40 family.

1306519:BIW12 RS15220
gene id: 1306519:BIW12_RS15220
uniprot id: A0A1D9PDU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

1306519:BIW12 RS05200
gene id: 1306519:BIW12_RS05200
uniprot id: A0A1D9P8J3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS13870
gene id: 1306519:BIW12_RS13870
uniprot id: A0A1D9PCV1
names: Similarity
messages: Belongs to the UPF0173 family.

1306519:BIW12 RS10615
gene id: 1306519:BIW12_RS10615
uniprot id: A0A1D9PC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS03395
gene id: 1306519:BIW12_RS03395
uniprot id: A0A1D9P8B7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1306519:BIW12 RS08755
gene id: 1306519:BIW12_RS08755
uniprot id: A0A1D9PAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS03510
gene id: 1306519:BIW12_RS03510
uniprot id: A0A1D9P7L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1306519:BIW12 RS08380
gene id: 1306519:BIW12_RS08380
uniprot id: A0A1D9PA32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1306519:BIW12 RS01685
gene id: 1306519:BIW12_RS01685
uniprot id: A0A1D9P6R2
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

1306519:BIW12 RS03455
gene id: 1306519:BIW12_RS03455
uniprot id: A0A1D9P8X9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1306519:BIW12 RS06075
gene id: 1306519:BIW12_RS06075
uniprot id: A0A1D9P8Z8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1306519:BIW12 RS04315
gene id: 1306519:BIW12_RS04315
uniprot id: A0A1D9P871
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS03970
gene id: 1306519:BIW12_RS03970
uniprot id: A0A1D9P7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1306519:BIW12 RS00335
gene id: 1306519:BIW12_RS00335
uniprot id: A0A1D9P645
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1306519:BIW12 RS05255
gene id: 1306519:BIW12_RS05255
uniprot id: A0A1D9P8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1306519:BIW12 RS05355
gene id: 1306519:BIW12_RS05355
uniprot id: A0A1D9P8K0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS00600
gene id: 1306519:BIW12_RS00600
uniprot id: A0A1D9P6B9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1306519:BIW12 RS06685
gene id: 1306519:BIW12_RS06685
uniprot id: A0A1D9P995
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1306519:BIW12 RS03480
gene id: 1306519:BIW12_RS03480
uniprot id: A0A1D9P7L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1306519:BIW12 RS00425
gene id: 1306519:BIW12_RS00425
uniprot id: A0A1D9P6T6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS02975
gene id: 1306519:BIW12_RS02975
uniprot id: A0A1D9P790
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

1306519:BIW12 RS10030
gene id: 1306519:BIW12_RS10030
uniprot id: A0A1D9PB08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS04070
gene id: 1306519:BIW12_RS04070
uniprot id: A0A1D9P7X0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS00065
gene id: 1306519:BIW12_RS00065
uniprot id: A0A1D9P642
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS12470
gene id: 1306519:BIW12_RS12470
uniprot id: A0A1D9PEM3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS13180
gene id: 1306519:BIW12_RS13180
uniprot id: A0A1D9PCJ1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS15145
gene id: 1306519:BIW12_RS15145
uniprot id: A0A1D9PDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1306519:BIW12 RS04455
gene id: 1306519:BIW12_RS04455
uniprot id: A0A1D9P848
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1306519:BIW12 RS03795
gene id: 1306519:BIW12_RS03795
uniprot id: A0A1D9P7R7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1306519:BIW12 RS15300
gene id: 1306519:BIW12_RS15300
uniprot id: A0A1D9PDS0
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1306519:BIW12 RS14475
gene id: 1306519:BIW12_RS14475
uniprot id: A0A1D9PD66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1306519:BIW12 RS07490
gene id: 1306519:BIW12_RS07490
uniprot id: A0A1D9P9R4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1306519:BIW12 RS09500
gene id: 1306519:BIW12_RS09500
uniprot id: A0A1D9PAT9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1306519:BIW12 RS03560
gene id: 1306519:BIW12_RS03560
uniprot id: A0A1D9P7L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1306519:BIW12 RS12330
gene id: 1306519:BIW12_RS12330
uniprot id: A0A1D9PEI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS01795
gene id: 1306519:BIW12_RS01795
uniprot id: A0A1D9P6Y1
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1306519:BIW12 RS10885
gene id: 1306519:BIW12_RS10885
uniprot id: A0A1D9PBI8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1306519:BIW12 RS00470
gene id: 1306519:BIW12_RS00470
uniprot id: A0A1D9P6A0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS14560
gene id: 1306519:BIW12_RS14560
uniprot id: A0A1D9PDD2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1306519:BIW12 RS15540
gene id: 1306519:BIW12_RS15540
uniprot id: A0A1D9PDS4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS06610
gene id: 1306519:BIW12_RS06610
uniprot id: A0A1D9PAN0
names: Similarity
messages: Belongs to the asparagine synthetase family.

1306519:BIW12 RS09535
gene id: 1306519:BIW12_RS09535
uniprot id: A0A1D9PBE9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1306519:BIW12 RS04430
gene id: 1306519:BIW12_RS04430
uniprot id: A0A1D9P8W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS14570
gene id: 1306519:BIW12_RS14570
uniprot id: A0A1D9PDY4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1306519:BIW12 RS00585
gene id: 1306519:BIW12_RS00585
uniprot id: A0A1D9P663
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS05635
gene id: 1306519:BIW12_RS05635
uniprot id: A0A1D9P9H5
names: Similarity
messages: Belongs to the SCO1/2 family.

1306519:BIW12 RS10795
gene id: 1306519:BIW12_RS10795
uniprot id: A0A1D9PBI9
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

1306519:BIW12 RS03230
gene id: 1306519:BIW12_RS03230
uniprot id: A0A1D9P7L7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

1306519:BIW12 RS01525
gene id: 1306519:BIW12_RS01525
uniprot id: A0A1D9P7D2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

1306519:BIW12 RS04785
gene id: 1306519:BIW12_RS04785
uniprot id: A0A1D9P8B6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1306519:BIW12 RS02960
gene id: 1306519:BIW12_RS02960
uniprot id: A0A1D9P847
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS12345
gene id: 1306519:BIW12_RS12345
uniprot id: A0A1D9PC56
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS14565
gene id: 1306519:BIW12_RS14565
uniprot id: A0A1D9PD99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1306519:BIW12 RS04465
gene id: 1306519:BIW12_RS04465
uniprot id: A0A1D9PE69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS05990
gene id: 1306519:BIW12_RS05990
uniprot id: A0A1D9P902
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1306519:BIW12 RS12985
gene id: 1306519:BIW12_RS12985
uniprot id: A0A1D9PCF8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS07595
gene id: 1306519:BIW12_RS07595
uniprot id: A0A1D9P9T4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1306519:BIW12 RS04825
gene id: 1306519:BIW12_RS04825
uniprot id: A0A1D9P8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1306519:BIW12 RS00775
gene id: 1306519:BIW12_RS00775
uniprot id: A0A1D9P7L6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS04645
gene id: 1306519:BIW12_RS04645
uniprot id: A0A1D9P872
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS10005
gene id: 1306519:BIW12_RS10005
uniprot id: A0A1D9PAZ3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1306519:BIW12 RS04760
gene id: 1306519:BIW12_RS04760
uniprot id: A0A1D9P8A3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS03240
gene id: 1306519:BIW12_RS03240
uniprot id: A0A1D9P892
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1306519:BIW12 RS08660
gene id: 1306519:BIW12_RS08660
uniprot id: A0A1D9PAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS01670
gene id: 1306519:BIW12_RS01670
uniprot id: A0A1D9P6M4
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS01870
gene id: 1306519:BIW12_RS01870
uniprot id: A0A1D9P6R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1306519:BIW12 RS11280
gene id: 1306519:BIW12_RS11280
uniprot id: A0A1D9PBL8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS08275
gene id: 1306519:BIW12_RS08275
uniprot id: A0A1D9PA14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1306519:BIW12 RS07540
gene id: 1306519:BIW12_RS07540
uniprot id: A0A1D9P9S8
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

1306519:BIW12 RS13740
gene id: 1306519:BIW12_RS13740
uniprot id: A0A1D9PE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS12855
gene id: 1306519:BIW12_RS12855
uniprot id: A0A1D9PEJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

1306519:BIW12 RS15820
gene id: 1306519:BIW12_RS15820
uniprot id: A0A1D9PE50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1306519:BIW12 RS15250
gene id: 1306519:BIW12_RS15250
uniprot id: A0A1D9PDR2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1306519:BIW12 RS14545
gene id: 1306519:BIW12_RS14545
uniprot id: A0A1D9PD78
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS07320
gene id: 1306519:BIW12_RS07320
uniprot id: A0A1D9P9N6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1306519:BIW12 RS15700
gene id: 1306519:BIW12_RS15700
uniprot id: A0A1D9PDV4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS04180
gene id: 1306519:BIW12_RS04180
uniprot id: A0A1D9P7Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

1306519:BIW12 RS04705
gene id: 1306519:BIW12_RS04705
uniprot id: A0A1D9P8A0
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS03870
gene id: 1306519:BIW12_RS03870
uniprot id: A0A1D9P7X1
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1306519:BIW12 RS01270
gene id: 1306519:BIW12_RS01270
uniprot id: A0A1D9P6H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1306519:BIW12 RS15660
gene id: 1306519:BIW12_RS15660
uniprot id: A0A1D9PF35
names: Similarity
messages: Belongs to the peptidase C40 family.

1306519:BIW12 RS09625
gene id: 1306519:BIW12_RS09625
uniprot id: A0A1D9PAV9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1306519:BIW12 RS11140
gene id: 1306519:BIW12_RS11140
uniprot id: A0A1D9PCU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1306519:BIW12 RS09425
gene id: 1306519:BIW12_RS09425
uniprot id: A0A1D9PAT3
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS05195
gene id: 1306519:BIW12_RS05195
uniprot id: A0A1D9P8H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS14595
gene id: 1306519:BIW12_RS14595
uniprot id: A0A1D9PD90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1306519:BIW12 RS07330
gene id: 1306519:BIW12_RS07330
uniprot id: A0A1D9P9L9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1306519:BIW12 RS04015
gene id: 1306519:BIW12_RS04015
uniprot id: A0A1D9P983
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1306519:BIW12 RS06385
gene id: 1306519:BIW12_RS06385
uniprot id: A0A1D9P937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1306519:BIW12 RS05940
gene id: 1306519:BIW12_RS05940
uniprot id: A0A1D9PE74
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS04270
gene id: 1306519:BIW12_RS04270
uniprot id: A0A1D9P8T1
names: Similarity
messages: Belongs to the MreC family.

1306519:BIW12 RS05260
gene id: 1306519:BIW12_RS05260
uniprot id: A0A1D9P8I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS00700
gene id: 1306519:BIW12_RS00700
uniprot id: A0A1D9P681
names: Similarity
messages: Belongs to the nitroreductase family.

1306519:BIW12 RS01830
gene id: 1306519:BIW12_RS01830
uniprot id: A0A1D9P6W5
names: Similarity
messages: Belongs to the nitroreductase family.

1306519:BIW12 RS08360
gene id: 1306519:BIW12_RS08360
uniprot id: A0A1D9PA67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1306519:BIW12 RS03590
gene id: 1306519:BIW12_RS03590
uniprot id: A0A1D9P7U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1306519:BIW12 RS10915
gene id: 1306519:BIW12_RS10915
uniprot id: A0A1D9PBK6
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS14825
gene id: 1306519:BIW12_RS14825
uniprot id: A0A1D9PDC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1306519:BIW12 RS14090
gene id: 1306519:BIW12_RS14090
uniprot id: A0A1D9PCZ1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1306519:BIW12 RS08140
gene id: 1306519:BIW12_RS08140
uniprot id: A0A1D9PBD7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1306519:BIW12 RS10455
gene id: 1306519:BIW12_RS10455
uniprot id: A0A1D9PB91
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS03485
gene id: 1306519:BIW12_RS03485
uniprot id: A0A1D9P7M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1306519:BIW12 RS15580
gene id: 1306519:BIW12_RS15580
uniprot id: A0A1D9PEH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS09885
gene id: 1306519:BIW12_RS09885
uniprot id: A0A1D9PAX7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS12460
gene id: 1306519:BIW12_RS12460
uniprot id: A0A1D9PCX3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS07465
gene id: 1306519:BIW12_RS07465
uniprot id: A0A1D9P9T5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1306519:BIW12 RS03540
gene id: 1306519:BIW12_RS03540
uniprot id: A0A1D9P7U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1306519:BIW12 RS08000
gene id: 1306519:BIW12_RS08000
uniprot id: A0A1D9PA16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS06050
gene id: 1306519:BIW12_RS06050
uniprot id: A0A1D9PED8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1306519:BIW12 RS12335
gene id: 1306519:BIW12_RS12335
uniprot id: A0A1D9PC69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

1306519:BIW12 RS06145
gene id: 1306519:BIW12_RS06145
uniprot id: A0A1D9P903
names: Similarity
messages: Belongs to the peptidase S8 family.

1306519:BIW12 RS08410
gene id: 1306519:BIW12_RS08410
uniprot id: A0A1D9PBG5
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1306519:BIW12 RS10890
gene id: 1306519:BIW12_RS10890
uniprot id: A0A1D9PBE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1306519:BIW12 RS00135
gene id: 1306519:BIW12_RS00135
uniprot id: A0A1D9P5T5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS04820
gene id: 1306519:BIW12_RS04820
uniprot id: A0A1D9P8B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS13095
gene id: 1306519:BIW12_RS13095
uniprot id: A0A1D9PCI7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1306519:BIW12 RS04210
gene id: 1306519:BIW12_RS04210
uniprot id: A0A1D9P819
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1306519:BIW12 RS12910
gene id: 1306519:BIW12_RS12910
uniprot id: A0A1D9PCF9
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1306519:BIW12 RS08395
gene id: 1306519:BIW12_RS08395
uniprot id: A0A1D9PA65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1306519:BIW12 RS03440
gene id: 1306519:BIW12_RS03440
uniprot id: A0A1D9P7Q4
names: Similarity
messages: Belongs to the citrate synthase family.

1306519:BIW12 RS12400
gene id: 1306519:BIW12_RS12400
uniprot id: A0A1D9PC62
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

1306519:BIW12 RS04410
gene id: 1306519:BIW12_RS04410
uniprot id: A0A1D9P836
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS05460
gene id: 1306519:BIW12_RS05460
uniprot id: A0A1D9P8M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1306519:BIW12 RS04265
gene id: 1306519:BIW12_RS04265
uniprot id: A0A1D9P828
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12285
gene id: 1306519:BIW12_RS12285
uniprot id: A0A1D9PC45
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1306519:BIW12 RS07900
gene id: 1306519:BIW12_RS07900
uniprot id: A0A1D9PA15
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1306519:BIW12 RS05760
gene id: 1306519:BIW12_RS05760
uniprot id: A0A1D9P8U4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS11960
gene id: 1306519:BIW12_RS11960
uniprot id: A0A1D9PCN4
names: Similarity
messages: Belongs to the AHA1 family.

1306519:BIW12 RS06850
gene id: 1306519:BIW12_RS06850
uniprot id: A0A1D9P9G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1306519:BIW12 RS09605
gene id: 1306519:BIW12_RS09605
uniprot id: A0A1D9PC30
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1306519:BIW12 RS01495
gene id: 1306519:BIW12_RS01495
uniprot id: A0A1D9P6N7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1306519:BIW12 RS11710
gene id: 1306519:BIW12_RS11710
uniprot id: A0A1D9PBV9
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1306519:BIW12 RS14600
gene id: 1306519:BIW12_RS14600
uniprot id: A0A1D9PD77
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1306519:BIW12 RS15115
gene id: 1306519:BIW12_RS15115
uniprot id: A0A1D9PDJ8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS15195
gene id: 1306519:BIW12_RS15195
uniprot id: A0A1D9PDQ3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1306519:BIW12 RS01460
gene id: 1306519:BIW12_RS01460
uniprot id: A0A1D9PET4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell.

1306519:BIW12 RS13980
gene id: 1306519:BIW12_RS13980
uniprot id: A0A1D9PCX2
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1306519:BIW12 RS16015
gene id: 1306519:BIW12_RS16015
uniprot id: A0A1D9P602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1306519:BIW12 RS02560
gene id: 1306519:BIW12_RS02560
uniprot id: A0A1D9P7A8
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

1306519:BIW12 RS12135
gene id: 1306519:BIW12_RS12135
uniprot id: A0A1D9PDB3
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS10225
gene id: 1306519:BIW12_RS10225
uniprot id: A0A1D9PBS5
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS10180
gene id: 1306519:BIW12_RS10180
uniprot id: A0A1D9PB52
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS01955
gene id: 1306519:BIW12_RS01955
uniprot id: A0A1D9P7L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1306519:BIW12 RS14330
gene id: 1306519:BIW12_RS14330
uniprot id: A0A1D9PDU9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Homodimer.

1306519:BIW12 RS04605
gene id: 1306519:BIW12_RS04605
uniprot id: A0A1D9P8Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS01275
gene id: 1306519:BIW12_RS01275
uniprot id: A0A1D9P6G0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1306519:BIW12 RS04790
gene id: 1306519:BIW12_RS04790
uniprot id: A0A1D9PE76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

1306519:BIW12 RS04870
gene id: 1306519:BIW12_RS04870
uniprot id: A0A1D9P8C1
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS02005
gene id: 1306519:BIW12_RS02005
uniprot id: A0A1D9P7M5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1306519:BIW12 RS07915
gene id: 1306519:BIW12_RS07915
uniprot id: A0A1D9PAM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS09705
gene id: 1306519:BIW12_RS09705
uniprot id: A0A1D9PAU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS05310
gene id: 1306519:BIW12_RS05310
uniprot id: A0A1D9P8L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS10590
gene id: 1306519:BIW12_RS10590
uniprot id: A0A1D9PBB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1306519:BIW12 RS11180
gene id: 1306519:BIW12_RS11180
uniprot id: A0A1D9PBJ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS00435
gene id: 1306519:BIW12_RS00435
uniprot id: A0A1D9P5X8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.
messages: Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS16610
gene id: 1306519:BIW12_RS16610
uniprot id: A0A1D9P6L5
names: Similarity
messages: Belongs to the sulfatase family.

1306519:BIW12 RS03730
gene id: 1306519:BIW12_RS03730
uniprot id: A0A1D9P7P3
names: Similarity
messages: Belongs to the GbsR family.

1306519:BIW12 RS13240
gene id: 1306519:BIW12_RS13240
uniprot id: A0A1D9PCI4
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS14920
gene id: 1306519:BIW12_RS14920
uniprot id: A0A1D9PDE1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS09780
gene id: 1306519:BIW12_RS09780
uniprot id: A0A1D9PAV6
names: Similarity
messages: Belongs to the glycosyl hydrolase.

1306519:BIW12 RS09540
gene id: 1306519:BIW12_RS09540
uniprot id: A0A1D9PC22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1306519:BIW12 RS12960
gene id: 1306519:BIW12_RS12960
uniprot id: A0A1D9PCK1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

1306519:BIW12 RS06840
gene id: 1306519:BIW12_RS06840
uniprot id: A0A1D9P9C2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1306519:BIW12 RS10165
gene id: 1306519:BIW12_RS10165
uniprot id: A0A1D9PCD8
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS02870
gene id: 1306519:BIW12_RS02870
uniprot id: A0A1D9P7D0
names: Similarity
messages: Belongs to the AIR synthase family.

1306519:BIW12 RS05185
gene id: 1306519:BIW12_RS05185
uniprot id: A0A1D9P8I9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS15190
gene id: 1306519:BIW12_RS15190
uniprot id: A0A1D9PDN6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1306519:BIW12 RS09435
gene id: 1306519:BIW12_RS09435
uniprot id: A0A1D9PBD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1306519:BIW12 RS06700
gene id: 1306519:BIW12_RS06700
uniprot id: A0A1D9P9A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

1306519:BIW12 RS07040
gene id: 1306519:BIW12_RS07040
uniprot id: A0A1D9P9G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS15670
gene id: 1306519:BIW12_RS15670
uniprot id: A0A1D9PE19
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS15025
gene id: 1306519:BIW12_RS15025
uniprot id: A0A1D9PDG1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS08990
gene id: 1306519:BIW12_RS08990
uniprot id: A0A1D9PB60
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS03715
gene id: 1306519:BIW12_RS03715
uniprot id: A0A1D9P931
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1306519:BIW12 RS04360
gene id: 1306519:BIW12_RS04360
uniprot id: A0A1D9PCM8
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS15125
gene id: 1306519:BIW12_RS15125
uniprot id: A0A1D9PDI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1306519:BIW12 RS03950
gene id: 1306519:BIW12_RS03950
uniprot id: A0A1D9P7Y4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS15350
gene id: 1306519:BIW12_RS15350
uniprot id: A0A1D9PDM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1306519:BIW12 RS05325
gene id: 1306519:BIW12_RS05325
uniprot id: A0A1D9P8Q8
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

1306519:BIW12 RS14105
gene id: 1306519:BIW12_RS14105
uniprot id: A0A1D9PD24
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS11820
gene id: 1306519:BIW12_RS11820
uniprot id: A0A1D9PBV5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1306519:BIW12 RS00990
gene id: 1306519:BIW12_RS00990
uniprot id: A0A1D9P6B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1306519:BIW12 RS14590
gene id: 1306519:BIW12_RS14590
uniprot id: A0A1D9PD82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1306519:BIW12 RS06375
gene id: 1306519:BIW12_RS06375
uniprot id: A0A1D9P934
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1306519:BIW12 RS09465
gene id: 1306519:BIW12_RS09465
uniprot id: A0A1D9PAM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1306519:BIW12 RS15655
gene id: 1306519:BIW12_RS15655
uniprot id: A0A1D9PEI5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1306519:BIW12 RS03010
gene id: 1306519:BIW12_RS03010
uniprot id: A0A1D9P7I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1306519:BIW12 RS06040
gene id: 1306519:BIW12_RS06040
uniprot id: A0A1D9P8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1306519:BIW12 RS06500
gene id: 1306519:BIW12_RS06500
uniprot id: A0A1D9P9X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

1306519:BIW12 RS10040
gene id: 1306519:BIW12_RS10040
uniprot id: A0A1D9PB07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS12900
gene id: 1306519:BIW12_RS12900
uniprot id: A0A1D9PCH1
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

1306519:BIW12 RS07720
gene id: 1306519:BIW12_RS07720
uniprot id: A0A1D9P9T1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS12425
gene id: 1306519:BIW12_RS12425
uniprot id: A0A1D9PC54
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1306519:BIW12 RS13000
gene id: 1306519:BIW12_RS13000
uniprot id: A0A1D9PCG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1306519:BIW12 RS05650
gene id: 1306519:BIW12_RS05650
uniprot id: A0A1D9P8S4
names: Similarity
messages: Belongs to the DtxR/MntR family.

1306519:BIW12 RS10785
gene id: 1306519:BIW12_RS10785
uniprot id: A0A1D9PCN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS01640
gene id: 1306519:BIW12_RS01640
uniprot id: A0A1D9P6V2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1306519:BIW12 RS08105
gene id: 1306519:BIW12_RS08105
uniprot id: A0A1D9PA03
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

1306519:BIW12 RS03190
gene id: 1306519:BIW12_RS03190
uniprot id: A0A1D9P7D9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12260
gene id: 1306519:BIW12_RS12260
uniprot id: A0A1D9PC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS06515
gene id: 1306519:BIW12_RS06515
uniprot id: A0A1D9P986
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1306519:BIW12 RS08290
gene id: 1306519:BIW12_RS08290
uniprot id: A0A1D9PA88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS13640
gene id: 1306519:BIW12_RS13640
uniprot id: A0A1D9PCY6
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS11335
gene id: 1306519:BIW12_RS11335
uniprot id: A0A1D9PBR8
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

1306519:BIW12 RS10545
gene id: 1306519:BIW12_RS10545
uniprot id: A0A1D9PB87
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1306519:BIW12 RS02285
gene id: 1306519:BIW12_RS02285
uniprot id: A0A1D9P7U2
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1306519:BIW12 RS06000
gene id: 1306519:BIW12_RS06000
uniprot id: A0A1D9P9P4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1306519:BIW12 RS09685
gene id: 1306519:BIW12_RS09685
uniprot id: A0A1D9PEN3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS10295
gene id: 1306519:BIW12_RS10295
uniprot id: A0A1D9PBU6
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS02445
gene id: 1306519:BIW12_RS02445
uniprot id: A0A1D9P732
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS15260
gene id: 1306519:BIW12_RS15260
uniprot id: A0A1D9PEB8
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1306519:BIW12 RS03195
gene id: 1306519:BIW12_RS03195
uniprot id: A0A1D9P7D4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12365
gene id: 1306519:BIW12_RS12365
uniprot id: A0A1D9PC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS08235
gene id: 1306519:BIW12_RS08235
uniprot id: A0A1D9PA78
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1306519:BIW12 RS10985
gene id: 1306519:BIW12_RS10985
uniprot id: A0A1D9PBM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1306519:BIW12 RS10810
gene id: 1306519:BIW12_RS10810
uniprot id: A0A1D9PBD3
names: Similarity
messages: Belongs to the SCO1/2 family.

1306519:BIW12 RS01175
gene id: 1306519:BIW12_RS01175
uniprot id: A0A1D9P6G7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1306519:BIW12 RS09870
gene id: 1306519:BIW12_RS09870
uniprot id: A0A1D9PAU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1306519:BIW12 RS04075
gene id: 1306519:BIW12_RS04075
uniprot id: A0A1D9P7X2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1306519:BIW12 RS04690
gene id: 1306519:BIW12_RS04690
uniprot id: A0A1D9P888
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS01105
gene id: 1306519:BIW12_RS01105
uniprot id: A0A1D9P6C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

1306519:BIW12 RS05570
gene id: 1306519:BIW12_RS05570
uniprot id: A0A1D9P8P6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1306519:BIW12 RS05535
gene id: 1306519:BIW12_RS05535
uniprot id: A0A1D9P8Q4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1306519:BIW12 RS12160
gene id: 1306519:BIW12_RS12160
uniprot id: A0A1D9PC07
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS12000
gene id: 1306519:BIW12_RS12000
uniprot id: A0A1D9PC09
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS15345
gene id: 1306519:BIW12_RS15345
uniprot id: A0A1D9PDM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1306519:BIW12 RS05360
gene id: 1306519:BIW12_RS05360
uniprot id: A0A1D9P8M2
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

1306519:BIW12 RS06380
gene id: 1306519:BIW12_RS06380
uniprot id: A0A1D9P936
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1306519:BIW12 RS14540
gene id: 1306519:BIW12_RS14540
uniprot id: A0A1D9PD73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1306519:BIW12 RS00420
gene id: 1306519:BIW12_RS00420
uniprot id: A0A1D9P697
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1306519:BIW12 RS04365
gene id: 1306519:BIW12_RS04365
uniprot id: A0A1D9P881
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1306519:BIW12 RS14340
gene id: 1306519:BIW12_RS14340
uniprot id: A0A1D9PEL9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1306519:BIW12 RS07535
gene id: 1306519:BIW12_RS07535
uniprot id: A0A1D9PB36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1306519:BIW12 RS15400
gene id: 1306519:BIW12_RS15400
uniprot id: A0A1D9PDN9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1306519:BIW12 RS02580
gene id: 1306519:BIW12_RS02580
uniprot id: A0A1D9P8E4
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS14350
gene id: 1306519:BIW12_RS14350
uniprot id: A0A1D9PDC2
names: Caution
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS03565
gene id: 1306519:BIW12_RS03565
uniprot id: A0A1D9P7L4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1306519:BIW12 RS05160
gene id: 1306519:BIW12_RS05160
uniprot id: A0A1D9P8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS05600
gene id: 1306519:BIW12_RS05600
uniprot id: A0A1D9P8R1
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1306519:BIW12 RS15800
gene id: 1306519:BIW12_RS15800
uniprot id: A0A1D9PDX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

1306519:BIW12 RS04005
gene id: 1306519:BIW12_RS04005
uniprot id: A0A1D9P7Z0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS01935
gene id: 1306519:BIW12_RS01935
uniprot id: A0A1D9P6V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1306519:BIW12 RS14055
gene id: 1306519:BIW12_RS14055
uniprot id: A0A1D9PD14
names: Similarity
messages: Belongs to the threonine synthase family.

1306519:BIW12 RS03630
gene id: 1306519:BIW12_RS03630
uniprot id: A0A1D9P7P1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS14725
gene id: 1306519:BIW12_RS14725
uniprot id: A0A1D9PDF0
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1306519:BIW12 RS02200
gene id: 1306519:BIW12_RS02200
uniprot id: A0A1D9P703
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS08510
gene id: 1306519:BIW12_RS08510
uniprot id: A0A1D9PAY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

1306519:BIW12 RS14075
gene id: 1306519:BIW12_RS14075
uniprot id: A0A1D9PD72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1306519:BIW12 RS10720
gene id: 1306519:BIW12_RS10720
uniprot id: A0A1D9PC20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1306519:BIW12 RS11675
gene id: 1306519:BIW12_RS11675
uniprot id: A0A1D9PBT2
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS08995
gene id: 1306519:BIW12_RS08995
uniprot id: A0A1D9PBS4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1306519:BIW12 RS07485
gene id: 1306519:BIW12_RS07485
uniprot id: A0A1D9P9R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1306519:BIW12 RS02685
gene id: 1306519:BIW12_RS02685
uniprot id: A0A1D9P7Z7
names: Similarity
messages: Belongs to the DEAD box helicase family.

1306519:BIW12 RS08530
gene id: 1306519:BIW12_RS08530
uniprot id: A0A1D9PAB9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1306519:BIW12 RS01210
gene id: 1306519:BIW12_RS01210
uniprot id: A0A1D9P7T5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

1306519:BIW12 RS01615
gene id: 1306519:BIW12_RS01615
uniprot id: A0A1D9P6Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1306519:BIW12 RS01015
gene id: 1306519:BIW12_RS01015
uniprot id: A0A1D9P6L0
names: Similarity
messages: Belongs to the stealth family.

1306519:BIW12 RS01800
gene id: 1306519:BIW12_RS01800
uniprot id: A0A1D9P7I4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS10110
gene id: 1306519:BIW12_RS10110
uniprot id: A0A1D9PCC9
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS03670
gene id: 1306519:BIW12_RS03670
uniprot id: A0A1D9P7P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS05480
gene id: 1306519:BIW12_RS05480
uniprot id: A0A1D9P8P0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1306519:BIW12 RS00465
gene id: 1306519:BIW12_RS00465
uniprot id: A0A1D9P654
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1306519:BIW12 RS14195
gene id: 1306519:BIW12_RS14195
uniprot id: A0A1D9PD11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1306519:BIW12 RS08905
gene id: 1306519:BIW12_RS08905
uniprot id: A0A1D9PAF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS07815
gene id: 1306519:BIW12_RS07815
uniprot id: A0A1D9P9X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1306519:BIW12 RS11000
gene id: 1306519:BIW12_RS11000
uniprot id: A0A1D9PEF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1306519:BIW12 RS06150
gene id: 1306519:BIW12_RS06150
uniprot id: A0A1D9P900
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS01705
gene id: 1306519:BIW12_RS01705
uniprot id: A0A1D9P807
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS05330
gene id: 1306519:BIW12_RS05330
uniprot id: A0A1D9P8K9
names: Similarity
messages: Belongs to the aldose epimerase family.

1306519:BIW12 RS06890
gene id: 1306519:BIW12_RS06890
uniprot id: A0A1D9P9D2
names: Similarity
messages: Belongs to the peptidase S41A family.

1306519:BIW12 RS11760
gene id: 1306519:BIW12_RS11760
uniprot id: A0A1D9PBU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1306519:BIW12 RS14705
gene id: 1306519:BIW12_RS14705
uniprot id: A0A1D9PDA2
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1306519:BIW12 RS00325
gene id: 1306519:BIW12_RS00325
uniprot id: A0A1D9P5Z8
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

1306519:BIW12 RS05465
gene id: 1306519:BIW12_RS05465
uniprot id: A0A1D9P9E6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1306519:BIW12 RS14060
gene id: 1306519:BIW12_RS14060
uniprot id: A0A1D9PDQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS09700
gene id: 1306519:BIW12_RS09700
uniprot id: A0A1D9PAR1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS13025
gene id: 1306519:BIW12_RS13025
uniprot id: A0A1D9PEK2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1306519:BIW12 RS12320
gene id: 1306519:BIW12_RS12320
uniprot id: A0A1D9PC40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1306519:BIW12 RS07370
gene id: 1306519:BIW12_RS07370
uniprot id: A0A1D9P9P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1306519:BIW12 RS02105
gene id: 1306519:BIW12_RS02105
uniprot id: A0A1D9P733
names: Similarity
messages: Belongs to the glutamate synthase family.

1306519:BIW12 RS04400
gene id: 1306519:BIW12_RS04400
uniprot id: A0A1D9P841
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

1306519:BIW12 RS05925
gene id: 1306519:BIW12_RS05925
uniprot id: A0A1D9PE78
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS03535
gene id: 1306519:BIW12_RS03535
uniprot id: A0A1D9P7N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1306519:BIW12 RS01285
gene id: 1306519:BIW12_RS01285
uniprot id: A0A1D9P6J0
names: Similarity
messages: Belongs to the CinA family.

1306519:BIW12 RS03990
gene id: 1306519:BIW12_RS03990
uniprot id: A0A1D9P7U7
names: Function
names: Similarity
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

1306519:BIW12 RS00300
gene id: 1306519:BIW12_RS00300
uniprot id: A0A1D9P678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1306519:BIW12 RS10740
gene id: 1306519:BIW12_RS10740
uniprot id: A0A1D9PBB0
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS06770
gene id: 1306519:BIW12_RS06770
uniprot id: A0A1D9P9D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS14985
gene id: 1306519:BIW12_RS14985
uniprot id: A0A1D9PDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1306519:BIW12 RS07060
gene id: 1306519:BIW12_RS07060
uniprot id: A0A1D9P9L8
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS02925
gene id: 1306519:BIW12_RS02925
uniprot id: A0A1D9P7E0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1306519:BIW12 RS04885
gene id: 1306519:BIW12_RS04885
uniprot id: A0A1D9P8B9
names: Similarity
messages: Belongs to the peptidase S9A family.

1306519:BIW12 RS00040
gene id: 1306519:BIW12_RS00040
uniprot id: A0A1D9PFG5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS10340
gene id: 1306519:BIW12_RS10340
uniprot id: A0A1D9PB69
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

1306519:BIW12 RS05395
gene id: 1306519:BIW12_RS05395
uniprot id: A0A1D9P8R9
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS12150
gene id: 1306519:BIW12_RS12150
uniprot id: A0A1D9PFU7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS13220
gene id: 1306519:BIW12_RS13220
uniprot id: A0A1D9PCK0
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS01420
gene id: 1306519:BIW12_RS01420
uniprot id: A0A1D9P6K2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS09950
gene id: 1306519:BIW12_RS09950
uniprot id: A0A1D9PEG8
names: Similarity
messages: Belongs to the arginase family.

1306519:BIW12 RS08300
gene id: 1306519:BIW12_RS08300
uniprot id: A0A1D9PAU5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1306519:BIW12 RS04285
gene id: 1306519:BIW12_RS04285
uniprot id: A0A1D9P817
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS02220
gene id: 1306519:BIW12_RS02220
uniprot id: A0A1D9P7R8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1306519:BIW12 RS02985
gene id: 1306519:BIW12_RS02985
uniprot id: A0A1D9P7F0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1306519:BIW12 RS03520
gene id: 1306519:BIW12_RS03520
uniprot id: A0A1D9P7M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1306519:BIW12 RS06175
gene id: 1306519:BIW12_RS06175
uniprot id: A0A1D9P917
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1306519:BIW12 RS11355
gene id: 1306519:BIW12_RS11355
uniprot id: A0A1D9PBM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1306519:BIW12 RS13735
gene id: 1306519:BIW12_RS13735
uniprot id: A0A1D9PDJ4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1306519:BIW12 RS04745
gene id: 1306519:BIW12_RS04745
uniprot id: A0A1D9P9N9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1306519:BIW12 RS12775
gene id: 1306519:BIW12_RS12775
uniprot id: A0A1D9PCA4
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS11585
gene id: 1306519:BIW12_RS11585
uniprot id: A0A1D9PBQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1306519:BIW12 RS13615
gene id: 1306519:BIW12_RS13615
uniprot id: A0A1D9PCT2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1306519:BIW12 RS04335
gene id: 1306519:BIW12_RS04335
uniprot id: A0A1D9P835
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1306519:BIW12 RS14425
gene id: 1306519:BIW12_RS14425
uniprot id: A0A1D9PD93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1306519:BIW12 RS09655
gene id: 1306519:BIW12_RS09655
uniprot id: A0A1D9PAT6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1306519:BIW12 RS06980
gene id: 1306519:BIW12_RS06980
uniprot id: A0A1D9P9H7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1306519:BIW12 RS06855
gene id: 1306519:BIW12_RS06855
uniprot id: A0A1D9P9D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1306519:BIW12 RS11750
gene id: 1306519:BIW12_RS11750
uniprot id: A0A1D9PC06
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS13150
gene id: 1306519:BIW12_RS13150
uniprot id: A0A1D9PCJ8
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS14160
gene id: 1306519:BIW12_RS14160
uniprot id: A0A1D9PD62
names: Similarity
messages: Belongs to the thioredoxin family.

1306519:BIW12 RS14095
gene id: 1306519:BIW12_RS14095
uniprot id: A0A1D9PD33
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1306519:BIW12 RS12415
gene id: 1306519:BIW12_RS12415
uniprot id: A0A1D9PC61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1306519:BIW12 RS11145
gene id: 1306519:BIW12_RS11145
uniprot id: A0A1D9PBH8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1306519:BIW12 RS07010
gene id: 1306519:BIW12_RS07010
uniprot id: A0A1D9P9K6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1306519:BIW12 RS13625
gene id: 1306519:BIW12_RS13625
uniprot id: A0A1D9PE14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1306519:BIW12 RS01335
gene id: 1306519:BIW12_RS01335
uniprot id: A0A1D9P6K0
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS05605
gene id: 1306519:BIW12_RS05605
uniprot id: A0A1D9P8Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1306519:BIW12 RS03790
gene id: 1306519:BIW12_RS03790
uniprot id: A0A1D9P7U1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS10975
gene id: 1306519:BIW12_RS10975
uniprot id: A0A1D9PCR9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1306519:BIW12 RS03450
gene id: 1306519:BIW12_RS03450
uniprot id: A0A1D9P8C7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1306519:BIW12 RS07740
gene id: 1306519:BIW12_RS07740
uniprot id: A0A1D9P9Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1306519:BIW12 RS15520
gene id: 1306519:BIW12_RS15520
uniprot id: A0A1D9PDW4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1306519:BIW12 RS05530
gene id: 1306519:BIW12_RS05530
uniprot id: A0A1D9P8N9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS09485
gene id: 1306519:BIW12_RS09485
uniprot id: A0A1D9PBE0
names: Similarity
messages: Belongs to the peptidase M16 family.

1306519:BIW12 RS06115
gene id: 1306519:BIW12_RS06115
uniprot id: A0A1D9P9R3
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1306519:BIW12 RS00680
gene id: 1306519:BIW12_RS00680
uniprot id: A0A1D9P694
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS02555
gene id: 1306519:BIW12_RS02555
uniprot id: A0A1D9PE80
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS10710
gene id: 1306519:BIW12_RS10710
uniprot id: A0A1D9PBG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS09795
gene id: 1306519:BIW12_RS09795
uniprot id: A0A1D9PAV4
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS00625
gene id: 1306519:BIW12_RS00625
uniprot id: A0A1D9P637
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS03845
gene id: 1306519:BIW12_RS03845
uniprot id: A0A1D9P7S2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1306519:BIW12 RS06360
gene id: 1306519:BIW12_RS06360
uniprot id: A0A1D9P952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1306519:BIW12 RS14185
gene id: 1306519:BIW12_RS14185
uniprot id: A0A1D9PD25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1306519:BIW12 RS13020
gene id: 1306519:BIW12_RS13020
uniprot id: A0A1D9PER7
names: Subunit
messages: Monomer.

1306519:BIW12 RS07725
gene id: 1306519:BIW12_RS07725
uniprot id: A0A1D9P9T7
names: Similarity
messages: Belongs to the RecJ family.

1306519:BIW12 RS01790
gene id: 1306519:BIW12_RS01790
uniprot id: A0A1D9P6Y6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1306519:BIW12 RS15815
gene id: 1306519:BIW12_RS15815
uniprot id: A0A1D9PDX1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS07750
gene id: 1306519:BIW12_RS07750
uniprot id: A0A1D9PAJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS06015
gene id: 1306519:BIW12_RS06015
uniprot id: A0A1D9P8Z6
names: Similarity
messages: Belongs to the SufE family.

1306519:BIW12 RS09075
gene id: 1306519:BIW12_RS09075
uniprot id: A0A1D9PAF1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1306519:BIW12 RS03650
gene id: 1306519:BIW12_RS03650
uniprot id: A0A1D9P8G6
names: Similarity
messages: Belongs to the UPF0758 family.

1306519:BIW12 RS14610
gene id: 1306519:BIW12_RS14610
uniprot id: A0A1D9PDC9
names: Similarity
messages: Belongs to the peptidase M17 family.

1306519:BIW12 RS08165
gene id: 1306519:BIW12_RS08165
uniprot id: A0A1D9P9Z7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1306519:BIW12 RS10125
gene id: 1306519:BIW12_RS10125
uniprot id: A0A1D9PB15
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1306519:BIW12 RS03515
gene id: 1306519:BIW12_RS03515
uniprot id: A0A1D9P7K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1306519:BIW12 RS02930
gene id: 1306519:BIW12_RS02930
uniprot id: A0A1D9P7C2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS05495
gene id: 1306519:BIW12_RS05495
uniprot id: A0A1D9P8P2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS14345
gene id: 1306519:BIW12_RS14345
uniprot id: A0A1D9PD61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1306519:BIW12 RS14820
gene id: 1306519:BIW12_RS14820
uniprot id: A0A1D9PDC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1306519:BIW12 RS13200
gene id: 1306519:BIW12_RS13200
uniprot id: A0A1D9PCP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1306519:BIW12 RS01925
gene id: 1306519:BIW12_RS01925
uniprot id: A0A1D9P6S8
names: Similarity
messages: Belongs to the bleomycin resistance protein family.

1306519:BIW12 RS15225
gene id: 1306519:BIW12_RS15225
uniprot id: A0A1D9PDK3
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1306519:BIW12 RS04875
gene id: 1306519:BIW12_RS04875
uniprot id: A0A1D9P8E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS04540
gene id: 1306519:BIW12_RS04540
uniprot id: A0A1D9P8A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1306519:BIW12 RS00760
gene id: 1306519:BIW12_RS00760
uniprot id: A0A1D9P6G2
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1306519:BIW12 RS03815
gene id: 1306519:BIW12_RS03815
uniprot id: A0A1D9P7W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1306519:BIW12 RS14380
gene id: 1306519:BIW12_RS14380
uniprot id: A0A1D9PDA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1306519:BIW12 RS15335
gene id: 1306519:BIW12_RS15335
uniprot id: A0A1D9PDM3
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS13720
gene id: 1306519:BIW12_RS13720
uniprot id: A0A1D9PCW4
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS05240
gene id: 1306519:BIW12_RS05240
uniprot id: A0A1D9P8K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS00860
gene id: 1306519:BIW12_RS00860
uniprot id: A0A1D9P6B3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1306519:BIW12 RS15725
gene id: 1306519:BIW12_RS15725
uniprot id: A0A1D9PDU8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS13040
gene id: 1306519:BIW12_RS13040
uniprot id: A0A1D9PCH8
names: Similarity
messages: Belongs to the ArsC family.

1306519:BIW12 RS13950
gene id: 1306519:BIW12_RS13950
uniprot id: A0A1D9PDN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

1306519:BIW12 RS02815
gene id: 1306519:BIW12_RS02815
uniprot id: A0A1D9P7C4
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS13635
gene id: 1306519:BIW12_RS13635
uniprot id: A0A1D9PES6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS01000
gene id: 1306519:BIW12_RS01000
uniprot id: A0A1D9P6F0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1306519:BIW12 RS13970
gene id: 1306519:BIW12_RS13970
uniprot id: A0A1D9PCX0
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1306519:BIW12 RS05425
gene id: 1306519:BIW12_RS05425
uniprot id: A0A1D9P8N0
names: Similarity
messages: Belongs to the ribF family.

1306519:BIW12 RS14685
gene id: 1306519:BIW12_RS14685
uniprot id: A0A1D9PE05
names: Similarity
messages: Belongs to the DEAD box helicase family.

1306519:BIW12 RS11665
gene id: 1306519:BIW12_RS11665
uniprot id: A0A1D9PCI6
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS02210
gene id: 1306519:BIW12_RS02210
uniprot id: A0A1D9P756
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1306519:BIW12 RS02100
gene id: 1306519:BIW12_RS02100
uniprot id: A0A1D9P738
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1306519:BIW12 RS14485
gene id: 1306519:BIW12_RS14485
uniprot id: A0A1D9PD57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1306519:BIW12 RS12020
gene id: 1306519:BIW12_RS12020
uniprot id: A0A1D9PD98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

1306519:BIW12 RS07455
gene id: 1306519:BIW12_RS07455
uniprot id: A0A1D9P9N2
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS16550
gene id: 1306519:BIW12_RS16550
uniprot id: A0A1D9P7S7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1306519:BIW12 RS07215
gene id: 1306519:BIW12_RS07215
uniprot id: A0A1D9P9L6
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS05655
gene id: 1306519:BIW12_RS05655
uniprot id: A0A1D9P8P9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS00895
gene id: 1306519:BIW12_RS00895
uniprot id: A0A1D9P699
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS10635
gene id: 1306519:BIW12_RS10635
uniprot id: A0A1D9PB89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1306519:BIW12 RS04910
gene id: 1306519:BIW12_RS04910
uniprot id: A0A1D9P9S1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1306519:BIW12 RS09000
gene id: 1306519:BIW12_RS09000
uniprot id: A0A1D9PAH0
names: Similarity
messages: Belongs to the AHA1 family.

1306519:BIW12 RS03470
gene id: 1306519:BIW12_RS03470
uniprot id: A0A1D9P7K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1306519:BIW12 RS01080
gene id: 1306519:BIW12_RS01080
uniprot id: A0A1D9PE70
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1306519:BIW12 RS12755
gene id: 1306519:BIW12_RS12755
uniprot id: A0A1D9PCC2
names: Similarity
messages: Belongs to the universal stress protein A family.

1306519:BIW12 RS03250
gene id: 1306519:BIW12_RS03250
uniprot id: A0A1D9P7E9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1306519:BIW12 RS03005
gene id: 1306519:BIW12_RS03005
uniprot id: A0A1D9PE40
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1306519:BIW12 RS11435
gene id: 1306519:BIW12_RS11435
uniprot id: A0A1D9PBN1
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1306519:BIW12 RS05500
gene id: 1306519:BIW12_RS05500
uniprot id: A0A1D9P8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS03370
gene id: 1306519:BIW12_RS03370
uniprot id: A0A1D9P7M2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS04190
gene id: 1306519:BIW12_RS04190
uniprot id: A0A1D9P821
names: Similarity
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

1306519:BIW12 RS08390
gene id: 1306519:BIW12_RS08390
uniprot id: A0A1D9PAB1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1306519:BIW12 RS11730
gene id: 1306519:BIW12_RS11730
uniprot id: A0A1D9PBV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1306519:BIW12 RS06965
gene id: 1306519:BIW12_RS06965
uniprot id: A0A1D9PA56
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

1306519:BIW12 RS14700
gene id: 1306519:BIW12_RS14700
uniprot id: A0A1D9PDJ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS15960
gene id: 1306519:BIW12_RS15960
uniprot id: A0A1D9PDZ0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS06160
gene id: 1306519:BIW12_RS06160
uniprot id: A0A1D9P911
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS15890
gene id: 1306519:BIW12_RS15890
uniprot id: A0A1D9PDX8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1306519:BIW12 RS01205
gene id: 1306519:BIW12_RS01205
uniprot id: A0A1D9P772
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1306519:BIW12 RS01055
gene id: 1306519:BIW12_RS01055
uniprot id: A0A1D9P6F9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1306519:BIW12 RS08520
gene id: 1306519:BIW12_RS08520
uniprot id: A0A1D9PF38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1306519:BIW12 RS13165
gene id: 1306519:BIW12_RS13165
uniprot id: A0A1D9PEV3
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

1306519:BIW12 RS15665
gene id: 1306519:BIW12_RS15665
uniprot id: A0A1D9PDU1
names: Similarity
messages: Belongs to the CvfB family.

1306519:BIW12 RS11580
gene id: 1306519:BIW12_RS11580
uniprot id: A0A1D9PBR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1306519:BIW12 RS03280
gene id: 1306519:BIW12_RS03280
uniprot id: A0A1D9P7H1
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1306519:BIW12 RS02030
gene id: 1306519:BIW12_RS02030
uniprot id: A0A1D9P700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS05320
gene id: 1306519:BIW12_RS05320
uniprot id: A0A1D9PE66
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS11830
gene id: 1306519:BIW12_RS11830
uniprot id: A0A1D9PBY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1306519:BIW12 RS05585
gene id: 1306519:BIW12_RS05585
uniprot id: A0A1D9P8P8
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

1306519:BIW12 RS15965
gene id: 1306519:BIW12_RS15965
uniprot id: A0A1D9PDY9
names: Function
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.
messages: Broad-specificity glycosaminoglycan lyase.

1306519:BIW12 RS13090
gene id: 1306519:BIW12_RS13090
uniprot id: A0A1D9PCM2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1306519:BIW12 RS11070
gene id: 1306519:BIW12_RS11070
uniprot id: A0A1D9PBL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1306519:BIW12 RS11365
gene id: 1306519:BIW12_RS11365
uniprot id: A0A1D9PBM3
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1306519:BIW12 RS14550
gene id: 1306519:BIW12_RS14550
uniprot id: A0A1D9PD70
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS15235
gene id: 1306519:BIW12_RS15235
uniprot id: A0A1D9PDK9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS04135
gene id: 1306519:BIW12_RS04135
uniprot id: A0A1D9P7X3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS00340
gene id: 1306519:BIW12_RS00340
uniprot id: A0A1D9P624
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS03635
gene id: 1306519:BIW12_RS03635
uniprot id: A0A1D9P7R1
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1306519:BIW12 RS07970
gene id: 1306519:BIW12_RS07970
uniprot id: A0A1D9PAN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS12145
gene id: 1306519:BIW12_RS12145
uniprot id: A0A1D9PC73
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS02940
gene id: 1306519:BIW12_RS02940
uniprot id: A0A1D9P7H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1306519:BIW12 RS09600
gene id: 1306519:BIW12_RS09600
uniprot id: A0A1D9PBF6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1306519:BIW12 RS15690
gene id: 1306519:BIW12_RS15690
uniprot id: A0A1D9PDX7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1306519:BIW12 RS05235
gene id: 1306519:BIW12_RS05235
uniprot id: A0A1D9P8J7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS05250
gene id: 1306519:BIW12_RS05250
uniprot id: A0A1D9P8K5
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS15600
gene id: 1306519:BIW12_RS15600
uniprot id: A0A1D9PDS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1306519:BIW12 RS15905
gene id: 1306519:BIW12_RS15905
uniprot id: A0A1D9PDY3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS11160
gene id: 1306519:BIW12_RS11160
uniprot id: A0A1D9PBJ0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1306519:BIW12 RS07560
gene id: 1306519:BIW12_RS07560
uniprot id: A0A1D9P9Q5
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1306519:BIW12 RS08490
gene id: 1306519:BIW12_RS08490
uniprot id: A0A1D9PA52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1306519:BIW12 RS07420
gene id: 1306519:BIW12_RS07420
uniprot id: A0A1D9P9Q6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1306519:BIW12 RS10390
gene id: 1306519:BIW12_RS10390
uniprot id: A0A1D9PB54
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS10260
gene id: 1306519:BIW12_RS10260
uniprot id: A0A1D9PB64
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1306519:BIW12 RS02505
gene id: 1306519:BIW12_RS02505
uniprot id: A0A1D9P795
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1306519:BIW12 RS04755
gene id: 1306519:BIW12_RS04755
uniprot id: A0A1D9P897
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1306519:BIW12 RS12765
gene id: 1306519:BIW12_RS12765
uniprot id: A0A1D9PCB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1306519:BIW12 RS08080
gene id: 1306519:BIW12_RS08080
uniprot id: A0A1D9PA04
names: Similarity
messages: Belongs to the peptidase S41A family.

1306519:BIW12 RS11340
gene id: 1306519:BIW12_RS11340
uniprot id: A0A1D9PBM9
names: Similarity
messages: Belongs to the YoeB family.

1306519:BIW12 RS12930
gene id: 1306519:BIW12_RS12930
uniprot id: A0A1D9PCF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

1306519:BIW12 RS13080
gene id: 1306519:BIW12_RS13080
uniprot id: A0A1D9PFW8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS09945
gene id: 1306519:BIW12_RS09945
uniprot id: A0A1D9PC94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1306519:BIW12 RS15100
gene id: 1306519:BIW12_RS15100
uniprot id: A0A1D9PDJ9
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

1306519:BIW12 RS09325
gene id: 1306519:BIW12_RS09325
uniprot id: A0A1D9PEC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1306519:BIW12 RS05590
gene id: 1306519:BIW12_RS05590
uniprot id: A0A1D9P8R7
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS09510
gene id: 1306519:BIW12_RS09510
uniprot id: A0A1D9PAR9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS06875
gene id: 1306519:BIW12_RS06875
uniprot id: A0A1D9P9F5
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

1306519:BIW12 RS08740
gene id: 1306519:BIW12_RS08740
uniprot id: A0A1D9PAC8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

1306519:BIW12 RS13205
gene id: 1306519:BIW12_RS13205
uniprot id: A0A1D9PCK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1306519:BIW12 RS04960
gene id: 1306519:BIW12_RS04960
uniprot id: A0A1D9P967
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS06910
gene id: 1306519:BIW12_RS06910
uniprot id: A0A1D9PA49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS05020
gene id: 1306519:BIW12_RS05020
uniprot id: A0A1D9P9T2
names: Similarity
messages: Belongs to the asparaginase 1 family.

1306519:BIW12 RS04325
gene id: 1306519:BIW12_RS04325
uniprot id: A0A1D9P8V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1306519:BIW12 RS01330
gene id: 1306519:BIW12_RS01330
uniprot id: A0A1D9P6K6
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1306519:BIW12 RS12950
gene id: 1306519:BIW12_RS12950
uniprot id: A0A1D9PCD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS00240
gene id: 1306519:BIW12_RS00240
uniprot id: A0A1D9P620
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS01740
gene id: 1306519:BIW12_RS01740
uniprot id: A0A1D9P6X5
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1306519:BIW12 RS15010
gene id: 1306519:BIW12_RS15010
uniprot id: A0A1D9PDH9
names: Similarity
messages: Belongs to the arginase family.

1306519:BIW12 RS03705
gene id: 1306519:BIW12_RS03705
uniprot id: A0A1D9P7U6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS05295
gene id: 1306519:BIW12_RS05295
uniprot id: A0A1D9P8L4
names: Similarity
messages: Belongs to the peptidase S24 family.

1306519:BIW12 RS01360
gene id: 1306519:BIW12_RS01360
uniprot id: A0A1D9P7W0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1306519:BIW12 RS06480
gene id: 1306519:BIW12_RS06480
uniprot id: A0A1D9P956
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1306519:BIW12 RS03975
gene id: 1306519:BIW12_RS03975
uniprot id: A0A1D9P7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1306519:BIW12 RS08820
gene id: 1306519:BIW12_RS08820
uniprot id: A0A1D9PAE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Membrane

1306519:BIW12 RS08985
gene id: 1306519:BIW12_RS08985
uniprot id: A0A1D9PAG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1306519:BIW12 RS14135
gene id: 1306519:BIW12_RS14135
uniprot id: A0A1D9PD00
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS06735
gene id: 1306519:BIW12_RS06735
uniprot id: A0A1D9P9A4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1306519:BIW12 RS13130
gene id: 1306519:BIW12_RS13130
uniprot id: A0A1D9PCI8
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS12165
gene id: 1306519:BIW12_RS12165
uniprot id: A0A1D9PC02
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

1306519:BIW12 RS05555
gene id: 1306519:BIW12_RS05555
uniprot id: A0A1D9P8P7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS07630
gene id: 1306519:BIW12_RS07630
uniprot id: A0A1D9P9W5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1306519:BIW12 RS15325
gene id: 1306519:BIW12_RS15325
uniprot id: A0A1D9PDN5
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1306519:BIW12 RS03875
gene id: 1306519:BIW12_RS03875
uniprot id: A0A1D9P8K7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1306519:BIW12 RS02905
gene id: 1306519:BIW12_RS02905
uniprot id: A0A1D9P8M3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1306519:BIW12 RS04795
gene id: 1306519:BIW12_RS04795
uniprot id: A0A1D9P939
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1306519:BIW12 RS13160
gene id: 1306519:BIW12_RS13160
uniprot id: A0A1D9PDU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1306519:BIW12 RS15710
gene id: 1306519:BIW12_RS15710
uniprot id: A0A1D9PF46
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1306519:BIW12 RS06905
gene id: 1306519:BIW12_RS06905
uniprot id: A0A1D9P9E3
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1306519:BIW12 RS10420
gene id: 1306519:BIW12_RS10420
uniprot id: A0A1D9PBX4
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS15775
gene id: 1306519:BIW12_RS15775
uniprot id: A0A1D9PDV9
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1306519:BIW12 RS07855
gene id: 1306519:BIW12_RS07855
uniprot id: A0A1D9PAL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS01775
gene id: 1306519:BIW12_RS01775
uniprot id: A0A1D9P6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS10570
gene id: 1306519:BIW12_RS10570
uniprot id: A0A1D9PB77
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1306519:BIW12 RS10485
gene id: 1306519:BIW12_RS10485
uniprot id: A0A1D9PBC4
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

1306519:BIW12 RS07840
gene id: 1306519:BIW12_RS07840
uniprot id: A0A1D9P9V8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS00410
gene id: 1306519:BIW12_RS00410
uniprot id: A0A1D9P690
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1306519:BIW12 RS15110
gene id: 1306519:BIW12_RS15110
uniprot id: A0A1D9PET7
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1306519:BIW12 RS11570
gene id: 1306519:BIW12_RS11570
uniprot id: A0A1D9PBX6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS08645
gene id: 1306519:BIW12_RS08645
uniprot id: A0A1D9PB05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS01390
gene id: 1306519:BIW12_RS01390
uniprot id: A0A1D9P6K7
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS12035
gene id: 1306519:BIW12_RS12035
uniprot id: A0A1D9PC51
names: Similarity
messages: Belongs to the isochorismate synthase family.

1306519:BIW12 RS02920
gene id: 1306519:BIW12_RS02920
uniprot id: A0A1D9P7B9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS08160
gene id: 1306519:BIW12_RS08160
uniprot id: A0A1D9PA26
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS08345
gene id: 1306519:BIW12_RS08345
uniprot id: A0A1D9PA53
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS01680
gene id: 1306519:BIW12_RS01680
uniprot id: A0A1D9P6Q9
names: Similarity
messages: Belongs to the RuBisCO large chain family.

1306519:BIW12 RS01750
gene id: 1306519:BIW12_RS01750
uniprot id: A0A1D9P7H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1306519:BIW12 RS12570
gene id: 1306519:BIW12_RS12570
uniprot id: A0A1D9PCD5
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1306519:BIW12 RS13555
gene id: 1306519:BIW12_RS13555
uniprot id: A0A1D9PEN5
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

1306519:BIW12 RS04345
gene id: 1306519:BIW12_RS04345
uniprot id: A0A1D9P826
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12525
gene id: 1306519:BIW12_RS12525
uniprot id: A0A1D9PC90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS13575
gene id: 1306519:BIW12_RS13575
uniprot id: A0A1D9PCP9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1306519:BIW12 RS12580
gene id: 1306519:BIW12_RS12580
uniprot id: A0A1D9PCZ4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1306519:BIW12 RS09920
gene id: 1306519:BIW12_RS09920
uniprot id: A0A1D9PAV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1306519:BIW12 RS01355
gene id: 1306519:BIW12_RS01355
uniprot id: A0A1D9P7A4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1306519:BIW12 RS11715
gene id: 1306519:BIW12_RS11715
uniprot id: A0A1D9PES1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

1306519:BIW12 RS13185
gene id: 1306519:BIW12_RS13185
uniprot id: A0A1D9PCJ7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1306519:BIW12 RS10135
gene id: 1306519:BIW12_RS10135
uniprot id: A0A1D9PAZ9
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1306519:BIW12 RS03220
gene id: 1306519:BIW12_RS03220
uniprot id: A0A1D9P7G4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1306519:BIW12 RS13215
gene id: 1306519:BIW12_RS13215
uniprot id: A0A1D9PDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS03025
gene id: 1306519:BIW12_RS03025
uniprot id: A0A1D9P8P3
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1306519:BIW12 RS02680
gene id: 1306519:BIW12_RS02680
uniprot id: A0A1D9P7D1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1306519:BIW12 RS04890
gene id: 1306519:BIW12_RS04890
uniprot id: A0A1D9P8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS09400
gene id: 1306519:BIW12_RS09400
uniprot id: A0A1D9PAN1
names: Similarity
messages: Belongs to the pirin family.

1306519:BIW12 RS02315
gene id: 1306519:BIW12_RS02315
uniprot id: A0A1D9P753
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1306519:BIW12 RS04980
gene id: 1306519:BIW12_RS04980
uniprot id: A0A1D9P8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1306519:BIW12 RS15120
gene id: 1306519:BIW12_RS15120
uniprot id: A0A1D9PDS2
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS04700
gene id: 1306519:BIW12_RS04700
uniprot id: A0A1D9P889
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS14965
gene id: 1306519:BIW12_RS14965
uniprot id: A0A1D9PDF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

1306519:BIW12 RS08605
gene id: 1306519:BIW12_RS08605
uniprot id: A0A1D9PAA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1306519:BIW12 RS14830
gene id: 1306519:BIW12_RS14830
uniprot id: A0A1D9PDG5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1306519:BIW12 RS10600
gene id: 1306519:BIW12_RS10600
uniprot id: A0A1D9PBE1
names: Similarity
messages: Belongs to the Dps family.

1306519:BIW12 RS00190
gene id: 1306519:BIW12_RS00190
uniprot id: A0A1D9P655
names: Similarity
messages: Belongs to the aldose epimerase family.

1306519:BIW12 RS03120
gene id: 1306519:BIW12_RS03120
uniprot id: A0A1D9P7K4
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Belongs to the KdsC family.
messages: Homotetramer.

1306519:BIW12 RS06005
gene id: 1306519:BIW12_RS06005
uniprot id: A0A1D9PAB0
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1306519:BIW12 RS05915
gene id: 1306519:BIW12_RS05915
uniprot id: A0A1D9P8V5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1306519:BIW12 RS00765
gene id: 1306519:BIW12_RS00765
uniprot id: A0A1D9P6F6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS08915
gene id: 1306519:BIW12_RS08915
uniprot id: A0A1D9PAF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS02010
gene id: 1306519:BIW12_RS02010
uniprot id: A0A1D9P868
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1306519:BIW12 RS00220
gene id: 1306519:BIW12_RS00220
uniprot id: A0A1D9P5Y5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS08325
gene id: 1306519:BIW12_RS08325
uniprot id: A0A1D9PA51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1306519:BIW12 RS00205
gene id: 1306519:BIW12_RS00205
uniprot id: A0A1D9P7A6
names: Similarity
messages: Belongs to the ribulokinase family.

1306519:BIW12 RS10410
gene id: 1306519:BIW12_RS10410
uniprot id: A0A1D9PBA6
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS07185
gene id: 1306519:BIW12_RS07185
uniprot id: A0A1D9P9I2
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS07820
gene id: 1306519:BIW12_RS07820
uniprot id: A0A1D9P9Y4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS09455
gene id: 1306519:BIW12_RS09455
uniprot id: A0A1D9PAP6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS08760
gene id: 1306519:BIW12_RS08760
uniprot id: A0A1D9PB25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Membrane

1306519:BIW12 RS02705
gene id: 1306519:BIW12_RS02705
uniprot id: A0A1D9P776
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

1306519:BIW12 RS07760
gene id: 1306519:BIW12_RS07760
uniprot id: A0A1D9P9W4
names: Similarity
messages: Belongs to the sigma-54 factor family.

1306519:BIW12 RS07345
gene id: 1306519:BIW12_RS07345
uniprot id: A0A1D9P9R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1306519:BIW12 RS08795
gene id: 1306519:BIW12_RS08795
uniprot id: A0A1D9PAD4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS06280
gene id: 1306519:BIW12_RS06280
uniprot id: A0A1D9P916
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS13350
gene id: 1306519:BIW12_RS13350
uniprot id: A0A1D9PCM8
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS11060
gene id: 1306519:BIW12_RS11060
uniprot id: A0A1D9PBG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS04445
gene id: 1306519:BIW12_RS04445
uniprot id: A0A1D9P856
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS06590
gene id: 1306519:BIW12_RS06590
uniprot id: A0A1D9P978
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1306519:BIW12 RS13570
gene id: 1306519:BIW12_RS13570
uniprot id: A0A1D9PCR6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1306519:BIW12 RS07190
gene id: 1306519:BIW12_RS07190
uniprot id: A0A1D9P9N3
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS08450
gene id: 1306519:BIW12_RS08450
uniprot id: A0A1D9PAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1306519:BIW12 RS15130
gene id: 1306519:BIW12_RS15130
uniprot id: A0A1D9PDI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1306519:BIW12 RS05205
gene id: 1306519:BIW12_RS05205
uniprot id: A0A1D9P8J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS06370
gene id: 1306519:BIW12_RS06370
uniprot id: A0A1D9P938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1306519:BIW12 RS10980
gene id: 1306519:BIW12_RS10980
uniprot id: A0A1D9PBF0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1306519:BIW12 RS10865
gene id: 1306519:BIW12_RS10865
uniprot id: A0A1D9PBE2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1306519:BIW12 RS00210
gene id: 1306519:BIW12_RS00210
uniprot id: A0A1D9P5U3
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1306519:BIW12 RS11575
gene id: 1306519:BIW12_RS11575
uniprot id: A0A1D9PBQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1306519:BIW12 RS01785
gene id: 1306519:BIW12_RS01785
uniprot id: A0A1D9P6T1
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS07380
gene id: 1306519:BIW12_RS07380
uniprot id: A0A1D9P9M0
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1306519:BIW12 RS02065
gene id: 1306519:BIW12_RS02065
uniprot id: A0A1D9P876
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1306519:BIW12 RS07625
gene id: 1306519:BIW12_RS07625
uniprot id: A0A1D9P9R6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1306519:BIW12 RS08245
gene id: 1306519:BIW12_RS08245
uniprot id: A0A1D9PAT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1306519:BIW12 RS09050
gene id: 1306519:BIW12_RS09050
uniprot id: A0A1D9PBT4
names: Similarity
messages: Belongs to the peptidase S49 family.

1306519:BIW12 RS07015
gene id: 1306519:BIW12_RS07015
uniprot id: A0A1D9P9G2
names: Similarity
messages: Belongs to the DprA/Smf family.

1306519:BIW12 RS08705
gene id: 1306519:BIW12_RS08705
uniprot id: A0A1D9PBL7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS06365
gene id: 1306519:BIW12_RS06365
uniprot id: A0A1D9P951
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1306519:BIW12 RS06650
gene id: 1306519:BIW12_RS06650
uniprot id: A0A1D9P999
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1306519:BIW12 RS13560
gene id: 1306519:BIW12_RS13560
uniprot id: A0A1D9PCX7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS06885
gene id: 1306519:BIW12_RS06885
uniprot id: A0A1D9P9D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1306519:BIW12 RS15435
gene id: 1306519:BIW12_RS15435
uniprot id: A0A1D9PDQ6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1306519:BIW12 RS05950
gene id: 1306519:BIW12_RS05950
uniprot id: A0A1D9PA99
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1306519:BIW12 RS06100
gene id: 1306519:BIW12_RS06100
uniprot id: A0A1D9P8Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1306519:BIW12 RS14130
gene id: 1306519:BIW12_RS14130
uniprot id: A0A1D9PD83
names: Similarity
messages: Belongs to the UPF0246 family.

1306519:BIW12 RS01090
gene id: 1306519:BIW12_RS01090
uniprot id: A0A1D9P7S3
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS00795
gene id: 1306519:BIW12_RS00795
uniprot id: A0A1D9P680
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1306519:BIW12 RS10045
gene id: 1306519:BIW12_RS10045
uniprot id: A0A1D9PBP5
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS06785
gene id: 1306519:BIW12_RS06785
uniprot id: A0A1D9P9B9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1306519:BIW12 RS08630
gene id: 1306519:BIW12_RS08630
uniprot id: A0A1D9PAA6
names: Similarity
messages: Belongs to the DapA family.

1306519:BIW12 RS04955
gene id: 1306519:BIW12_RS04955
uniprot id: A0A1D9P8D9
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS09690
gene id: 1306519:BIW12_RS09690
uniprot id: A0A1D9PAT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS14140
gene id: 1306519:BIW12_RS14140
uniprot id: A0A1D9PEP4
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS02550
gene id: 1306519:BIW12_RS02550
uniprot id: A0A1D9P751
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS05595
gene id: 1306519:BIW12_RS05595
uniprot id: A0A1D9P8N6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1306519:BIW12 RS13960
gene id: 1306519:BIW12_RS13960
uniprot id: A0A1D9PCY7
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS10445
gene id: 1306519:BIW12_RS10445
uniprot id: A0A1D9PB83
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1306519:BIW12 RS10990
gene id: 1306519:BIW12_RS10990
uniprot id: A0A1D9PBE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1306519:BIW12 RS11895
gene id: 1306519:BIW12_RS11895
uniprot id: A0A1D9PBX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1306519:BIW12 RS11345
gene id: 1306519:BIW12_RS11345
uniprot id: A0A1D9PCD0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1306519:BIW12 RS02585
gene id: 1306519:BIW12_RS02585
uniprot id: A0A1D9P723
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS05315
gene id: 1306519:BIW12_RS05315
uniprot id: A0A1D9P8J4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1306519:BIW12 RS06730
gene id: 1306519:BIW12_RS06730
uniprot id: A0A1D9P9A9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1306519:BIW12 RS12925
gene id: 1306519:BIW12_RS12925
uniprot id: A0A1D9PDQ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1306519:BIW12 RS03425
gene id: 1306519:BIW12_RS03425
uniprot id: A0A1D9P7N2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1306519:BIW12 RS05525
gene id: 1306519:BIW12_RS05525
uniprot id: A0A1D9PA19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS07290
gene id: 1306519:BIW12_RS07290
uniprot id: A0A1D9P9K4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1306519:BIW12 RS15280
gene id: 1306519:BIW12_RS15280
uniprot id: A0A1D9PDL3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1306519:BIW12 RS02880
gene id: 1306519:BIW12_RS02880
uniprot id: A0A1D9PED3
names: Similarity
messages: Belongs to the glutamine synthetase family.

1306519:BIW12 RS14975
gene id: 1306519:BIW12_RS14975
uniprot id: A0A1D9PDF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS08110
gene id: 1306519:BIW12_RS08110
uniprot id: A0A1D9PA10
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1306519:BIW12 RS00415
gene id: 1306519:BIW12_RS00415
uniprot id: A0A1D9PES2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS03525
gene id: 1306519:BIW12_RS03525
uniprot id: A0A1D9P7Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1306519:BIW12 RS08285
gene id: 1306519:BIW12_RS08285
uniprot id: A0A1D9PA47
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

1306519:BIW12 RS11870
gene id: 1306519:BIW12_RS11870
uniprot id: A0A1D9PBV1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS01440
gene id: 1306519:BIW12_RS01440
uniprot id: A0A1D9P6L6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS01280
gene id: 1306519:BIW12_RS01280
uniprot id: A0A1D9P6J7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1306519:BIW12 RS11790
gene id: 1306519:BIW12_RS11790
uniprot id: A0A1D9PBV6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1306519:BIW12 RS05835
gene id: 1306519:BIW12_RS05835
uniprot id: A0A1D9P9L4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 3-HAO family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

1306519:BIW12 RS00075
gene id: 1306519:BIW12_RS00075
uniprot id: A0A1D9PDY9
names: Function
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.
messages: Broad-specificity glycosaminoglycan lyase.

1306519:BIW12 RS06350
gene id: 1306519:BIW12_RS06350
uniprot id: A0A1D9P9V4
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1306519:BIW12 RS03840
gene id: 1306519:BIW12_RS03840
uniprot id: A0A1D9P7R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1306519:BIW12 RS03260
gene id: 1306519:BIW12_RS03260
uniprot id: A0A1D9P7H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1306519:BIW12 RS01905
gene id: 1306519:BIW12_RS01905
uniprot id: A0A1D9P7K5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS06985
gene id: 1306519:BIW12_RS06985
uniprot id: A0A1D9PE84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1306519:BIW12 RS09720
gene id: 1306519:BIW12_RS09720
uniprot id: A0A1D9PAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1306519:BIW12 RS13955
gene id: 1306519:BIW12_RS13955
uniprot id: A0A1D9PE71
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1306519:BIW12 RS07505
gene id: 1306519:BIW12_RS07505
uniprot id: A0A1D9P9N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1306519:BIW12 RS08515
gene id: 1306519:BIW12_RS08515
uniprot id: A0A1D9PBI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1306519:BIW12 RS14585
gene id: 1306519:BIW12_RS14585
uniprot id: A0A1D9PDH0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1306519:BIW12 RS14015
gene id: 1306519:BIW12_RS14015
uniprot id: A0A1D9PEM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1306519:BIW12 RS02145
gene id: 1306519:BIW12_RS02145
uniprot id: A0A1D9P6Z8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS04915
gene id: 1306519:BIW12_RS04915
uniprot id: A0A1D9P8D6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1306519:BIW12 RS14840
gene id: 1306519:BIW12_RS14840
uniprot id: A0A1D9PDE5
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1306519:BIW12 RS08075
gene id: 1306519:BIW12_RS08075
uniprot id: A0A1D9PA44
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1306519:BIW12 RS09840
gene id: 1306519:BIW12_RS09840
uniprot id: A0A1D9PBK4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1306519:BIW12 RS11405
gene id: 1306519:BIW12_RS11405
uniprot id: A0A1D9PBM8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1306519:BIW12 RS02495
gene id: 1306519:BIW12_RS02495
uniprot id: A0A1D9P754
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS00510
gene id: 1306519:BIW12_RS00510
uniprot id: A0A1D9P621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1306519:BIW12 RS05615
gene id: 1306519:BIW12_RS05615
uniprot id: A0A1D9PE77
names: Similarity
messages: Belongs to the pyruvate kinase family.

1306519:BIW12 RS14680
gene id: 1306519:BIW12_RS14680
uniprot id: A0A1D9PDB6
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1306519:BIW12 RS12705
gene id: 1306519:BIW12_RS12705
uniprot id: A0A1D9PDW2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS07765
gene id: 1306519:BIW12_RS07765
uniprot id: A0A1D9P9X2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS12340
gene id: 1306519:BIW12_RS12340
uniprot id: A0A1D9PC99
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS03530
gene id: 1306519:BIW12_RS03530
uniprot id: A0A1D9P7L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1306519:BIW12 RS11150
gene id: 1306519:BIW12_RS11150
uniprot id: A0A1D9PBQ2
names: Similarity
messages: Belongs to the IMPACT family.

1306519:BIW12 RS01590
gene id: 1306519:BIW12_RS01590
uniprot id: A0A1D9P7E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1306519:BIW12 RS14580
gene id: 1306519:BIW12_RS14580
uniprot id: A0A1D9PD96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS09915
gene id: 1306519:BIW12_RS09915
uniprot id: A0A1D9PAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1306519:BIW12 RS04625
gene id: 1306519:BIW12_RS04625
uniprot id: A0A1D9P880
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1306519:BIW12 RS05410
gene id: 1306519:BIW12_RS05410
uniprot id: A0A1D9P9D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1306519:BIW12 RS06930
gene id: 1306519:BIW12_RS06930
uniprot id: A0A1D9P9E9
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1306519:BIW12 RS00865
gene id: 1306519:BIW12_RS00865
uniprot id: A0A1D9P6I1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS11795
gene id: 1306519:BIW12_RS11795
uniprot id: A0A1D9PCK4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1306519:BIW12 RS00855
gene id: 1306519:BIW12_RS00855
uniprot id: A0A1D9PDX3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS12625
gene id: 1306519:BIW12_RS12625
uniprot id: A0A1D9PCE5
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

1306519:BIW12 RS05210
gene id: 1306519:BIW12_RS05210
uniprot id: A0A1D9P8H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS00440
gene id: 1306519:BIW12_RS00440
uniprot id: A0A1D9P615
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1306519:BIW12 RS00520
gene id: 1306519:BIW12_RS00520
uniprot id: A0A1D9P651
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1306519:BIW12 RS09505
gene id: 1306519:BIW12_RS09505
uniprot id: A0A1D9PAQ8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS12840
gene id: 1306519:BIW12_RS12840
uniprot id: A0A1D9PCG1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1306519:BIW12 RS02240
gene id: 1306519:BIW12_RS02240
uniprot id: A0A1D9P6Y7
names: Similarity
messages: Belongs to the DNA photolyase family.

1306519:BIW12 RS04495
gene id: 1306519:BIW12_RS04495
uniprot id: A0A1D9P863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS06575
gene id: 1306519:BIW12_RS06575
uniprot id: A0A1D9P969
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1306519:BIW12 RS05105
gene id: 1306519:BIW12_RS05105
uniprot id: A0A1D9P8H9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1306519:BIW12 RS09410
gene id: 1306519:BIW12_RS09410
uniprot id: A0A1D9PAL2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS01665
gene id: 1306519:BIW12_RS01665
uniprot id: A0A1D9P6N9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS08800
gene id: 1306519:BIW12_RS08800
uniprot id: A0A1D9PAH9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS08375
gene id: 1306519:BIW12_RS08375
uniprot id: A0A1D9PA60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1306519:BIW12 RS12560
gene id: 1306519:BIW12_RS12560
uniprot id: A0A1D9PC70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1306519:BIW12 RS07785
gene id: 1306519:BIW12_RS07785
uniprot id: A0A1D9P9S9
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS10970
gene id: 1306519:BIW12_RS10970
uniprot id: A0A1D9PC64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1306519:BIW12 RS02825
gene id: 1306519:BIW12_RS02825
uniprot id: A0A1D9P797
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1306519:BIW12 RS11805
gene id: 1306519:BIW12_RS11805
uniprot id: A0A1D9PBU8
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS15210
gene id: 1306519:BIW12_RS15210
uniprot id: A0A1D9PEV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1306519:BIW12 RS14025
gene id: 1306519:BIW12_RS14025
uniprot id: A0A1D9PD63
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS05220
gene id: 1306519:BIW12_RS05220
uniprot id: A0A1D9P8J6
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1306519:BIW12 RS08175
gene id: 1306519:BIW12_RS08175
uniprot id: A0A1D9PEA8
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS10995
gene id: 1306519:BIW12_RS10995
uniprot id: A0A1D9PBG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1306519:BIW12 RS03030
gene id: 1306519:BIW12_RS03030
uniprot id: A0A1D9P799
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1306519:BIW12 RS08540
gene id: 1306519:BIW12_RS08540
uniprot id: A0A1D9PA87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1306519:BIW12 RS15695
gene id: 1306519:BIW12_RS15695
uniprot id: A0A1D9PDZ3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1306519:BIW12 RS15595
gene id: 1306519:BIW12_RS15595
uniprot id: A0A1D9PE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1306519:BIW12 RS01695
gene id: 1306519:BIW12_RS01695
uniprot id: A0A1D9P6W7
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS15805
gene id: 1306519:BIW12_RS15805
uniprot id: A0A1D9PEM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

1306519:BIW12 RS02970
gene id: 1306519:BIW12_RS02970
uniprot id: A0A1D9P794
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS05245
gene id: 1306519:BIW12_RS05245
uniprot id: A0A1D9P8I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1306519:BIW12 RS09755
gene id: 1306519:BIW12_RS09755
uniprot id: A0A1D9PAU1
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

1306519:BIW12 RS07945
gene id: 1306519:BIW12_RS07945
uniprot id: A0A1D9P9X9
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

1306519:BIW12 RS14070
gene id: 1306519:BIW12_RS14070
uniprot id: A0A1D9PD06
names: Similarity
messages: Belongs to the UPF0111 family.

1306519:BIW12 RS12630
gene id: 1306519:BIW12_RS12630
uniprot id: A0A1D9PCB1
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1306519:BIW12 RS15270
gene id: 1306519:BIW12_RS15270
uniprot id: A0A1D9PDM7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1306519:BIW12 RS00515
gene id: 1306519:BIW12_RS00515
uniprot id: A0A1D9P665
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1306519:BIW12 RS04010
gene id: 1306519:BIW12_RS04010
uniprot id: A0A1D9P8M7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS04985
gene id: 1306519:BIW12_RS04985
uniprot id: A0A1D9P8G0
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1306519:BIW12 RS04255
gene id: 1306519:BIW12_RS04255
uniprot id: A0A1D9P804
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS07575
gene id: 1306519:BIW12_RS07575
uniprot id: A0A1D9P9V5
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1306519:BIW12 RS03100
gene id: 1306519:BIW12_RS03100
uniprot id: A0A1D9P7F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

1306519:BIW12 RS06780
gene id: 1306519:BIW12_RS06780
uniprot id: A0A1D9P9B6
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

1306519:BIW12 RS08230
gene id: 1306519:BIW12_RS08230
uniprot id: A0A1D9PA31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1306519:BIW12 RS04905
gene id: 1306519:BIW12_RS04905
uniprot id: A0A1D9P957
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS02855
gene id: 1306519:BIW12_RS02855
uniprot id: A0A1D9P775
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1306519:BIW12 RS01585
gene id: 1306519:BIW12_RS01585
uniprot id: A0A1D9P6U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

1306519:BIW12 RS06695
gene id: 1306519:BIW12_RS06695
uniprot id: A0A1D9P9D5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1306519:BIW12 RS12075
gene id: 1306519:BIW12_RS12075
uniprot id: A0A1D9PC08
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1306519:BIW12 RS10460
gene id: 1306519:BIW12_RS10460
uniprot id: A0A1D9PBC0
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1306519:BIW12 RS13285
gene id: 1306519:BIW12_RS13285
uniprot id: A0A1D9PCS4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS14750
gene id: 1306519:BIW12_RS14750
uniprot id: A0A1D9PEL6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1306519:BIW12 RS03245
gene id: 1306519:BIW12_RS03245
uniprot id: A0A1D9P8T2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1306519:BIW12 RS03255
gene id: 1306519:BIW12_RS03255
uniprot id: A0A1D9P7E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1306519:BIW12 RS02675
gene id: 1306519:BIW12_RS02675
uniprot id: A0A1D9P7C7
names: Similarity
messages: Belongs to the glutamate synthase family.

1306519:BIW12 RS12750
gene id: 1306519:BIW12_RS12750
uniprot id: A0A1D9PDM1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS08445
gene id: 1306519:BIW12_RS08445
uniprot id: A0A1D9PA80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1306519:BIW12 RS08115
gene id: 1306519:BIW12_RS08115
uniprot id: A0A1D9P9Y7
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS01195
gene id: 1306519:BIW12_RS01195
uniprot id: A0A1D9P6N8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS02170
gene id: 1306519:BIW12_RS02170
uniprot id: A0A1D9P891
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12475
gene id: 1306519:BIW12_RS12475
uniprot id: A0A1D9PEQ8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS12065
gene id: 1306519:BIW12_RS12065
uniprot id: A0A1D9PC18
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS00110
gene id: 1306519:BIW12_RS00110
uniprot id: A0A1D9P602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1306519:BIW12 RS09905
gene id: 1306519:BIW12_RS09905
uniprot id: A0A1D9PB06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS07340
gene id: 1306519:BIW12_RS07340
uniprot id: A0A1D9P9L3
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1306519:BIW12 RS04850
gene id: 1306519:BIW12_RS04850
uniprot id: A0A1D9P948
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1306519:BIW12 RS08980
gene id: 1306519:BIW12_RS08980
uniprot id: A0A1D9PAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

1306519:BIW12 RS07850
gene id: 1306519:BIW12_RS07850
uniprot id: A0A1D9P9W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required for cell division and gliding motility.

1306519:BIW12 RS05945
gene id: 1306519:BIW12_RS05945
uniprot id: A0A1D9P9N7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12495
gene id: 1306519:BIW12_RS12495
uniprot id: A0A1D9PCD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS01630
gene id: 1306519:BIW12_RS01630
uniprot id: A0A1D9P6Q3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS07295
gene id: 1306519:BIW12_RS07295
uniprot id: A0A1D9P9Q7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1306519:BIW12 RS04130
gene id: 1306519:BIW12_RS04130
uniprot id: A0A1D9P7Y2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1306519:BIW12 RS04730
gene id: 1306519:BIW12_RS04730
uniprot id: A0A1D9P8E0
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS05415
gene id: 1306519:BIW12_RS05415
uniprot id: A0A1D9P9Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1306519:BIW12 RS14395
gene id: 1306519:BIW12_RS14395
uniprot id: A0A1D9PEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1306519:BIW12 RS04260
gene id: 1306519:BIW12_RS04260
uniprot id: A0A1D9P861
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1306519:BIW12 RS08050
gene id: 1306519:BIW12_RS08050
uniprot id: A0A1D9PA25
names: Similarity
messages: Belongs to the aspartokinase family.

1306519:BIW12 RS02360
gene id: 1306519:BIW12_RS02360
uniprot id: A0A1D9P707
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1306519:BIW12 RS05690
gene id: 1306519:BIW12_RS05690
uniprot id: A0A1D9PA43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS01910
gene id: 1306519:BIW12_RS01910
uniprot id: A0A1D9P844
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS12850
gene id: 1306519:BIW12_RS12850
uniprot id: A0A1D9PCF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1306519:BIW12 RS14250
gene id: 1306519:BIW12_RS14250
uniprot id: A0A1D9PD27
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1306519:BIW12 RS14420
gene id: 1306519:BIW12_RS14420
uniprot id: A0A1D9PD47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1306519:BIW12 RS00975
gene id: 1306519:BIW12_RS00975
uniprot id: A0A1D9P734
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1306519:BIW12 RS05560
gene id: 1306519:BIW12_RS05560
uniprot id: A0A1D9P8N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS03585
gene id: 1306519:BIW12_RS03585
uniprot id: A0A1D9P7Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1306519:BIW12 RS07670
gene id: 1306519:BIW12_RS07670
uniprot id: A0A1D9P9S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

1306519:BIW12 RS07790
gene id: 1306519:BIW12_RS07790
uniprot id: A0A1D9P9U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS11410
gene id: 1306519:BIW12_RS11410
uniprot id: A0A1D9PBU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Heterotrimer of A, B and C subunits.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS01865
gene id: 1306519:BIW12_RS01865
uniprot id: A0A1D9P6R6
names: Similarity
messages: Belongs to the TrpF family.

1306519:BIW12 RS02455
gene id: 1306519:BIW12_RS02455
uniprot id: A0A1D9P792
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1306519:BIW12 RS00915
gene id: 1306519:BIW12_RS00915
uniprot id: A0A1D9P6J2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
messages: Membrane

1306519:BIW12 RS00500
gene id: 1306519:BIW12_RS00500
uniprot id: A0A1D9P5Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1306519:BIW12 RS07225
gene id: 1306519:BIW12_RS07225
uniprot id: A0A1D9PEJ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1306519:BIW12 RS04300
gene id: 1306519:BIW12_RS04300
uniprot id: A0A1D9P813
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1306519:BIW12 RS06635
gene id: 1306519:BIW12_RS06635
uniprot id: A0A1D9P984
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

1306519:BIW12 RS12895
gene id: 1306519:BIW12_RS12895
uniprot id: A0A1D9PCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS13695
gene id: 1306519:BIW12_RS13695
uniprot id: A0A1D9PCT6
names: Similarity
messages: Belongs to the LOG family.

1306519:BIW12 RS00280
gene id: 1306519:BIW12_RS00280
uniprot id: A0A1D9P636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS15160
gene id: 1306519:BIW12_RS15160
uniprot id: A0A1D9PEU7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

1306519:BIW12 RS14065
gene id: 1306519:BIW12_RS14065
uniprot id: A0A1D9PE91
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

1306519:BIW12 RS12610
gene id: 1306519:BIW12_RS12610
uniprot id: A0A1D9PC97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1306519:BIW12 RS15895
gene id: 1306519:BIW12_RS15895
uniprot id: A0A1D9PDX3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS04245
gene id: 1306519:BIW12_RS04245
uniprot id: A0A1D9P831
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS09470
gene id: 1306519:BIW12_RS09470
uniprot id: A0A1D9PAQ3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1306519:BIW12 RS03270
gene id: 1306519:BIW12_RS03270
uniprot id: A0A1D9P7H6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1306519:BIW12 RS08270
gene id: 1306519:BIW12_RS08270
uniprot id: A0A1D9PA41
names: Caution
names: Function
names: Similarity
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).

1306519:BIW12 RS14635
gene id: 1306519:BIW12_RS14635
uniprot id: A0A1D9PDZ4
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1306519:BIW12 RS07405
gene id: 1306519:BIW12_RS07405
uniprot id: A0A1D9P9N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1306519:BIW12 RS02885
gene id: 1306519:BIW12_RS02885
uniprot id: A0A1D9P7A7
names: Similarity
messages: Belongs to the glutamine synthetase family.

1306519:BIW12 RS11190
gene id: 1306519:BIW12_RS11190
uniprot id: A0A1D9PCV8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1306519:BIW12 RS15945
gene id: 1306519:BIW12_RS15945
uniprot id: A0A1D9PE83
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS00790
gene id: 1306519:BIW12_RS00790
uniprot id: A0A1D9PE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS04440
gene id: 1306519:BIW12_RS04440
uniprot id: A0A1D9P9H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1306519:BIW12 RS03545
gene id: 1306519:BIW12_RS03545
uniprot id: A0A1D9P7S5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1306519:BIW12 RS15855
gene id: 1306519:BIW12_RS15855
uniprot id: A0A1D9PE25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

1306519:BIW12 RS11635
gene id: 1306519:BIW12_RS11635
uniprot id: A0A1D9PBR6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1306519:BIW12 RS03575
gene id: 1306519:BIW12_RS03575
uniprot id: A0A1D9P7R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1306519:BIW12 RS05505
gene id: 1306519:BIW12_RS05505
uniprot id: A0A1D9P8M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1306519:BIW12 RS03755
gene id: 1306519:BIW12_RS03755
uniprot id: A0A1D9P7X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1306519:BIW12 RS14455
gene id: 1306519:BIW12_RS14455
uniprot id: A0A1D9PFY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1306519:BIW12 RS01995
gene id: 1306519:BIW12_RS01995
uniprot id: A0A1D9P719
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1306519:BIW12 RS09565
gene id: 1306519:BIW12_RS09565
uniprot id: A0A1D9PAR7
names: Similarity
messages: Belongs to the peptidase S51 family.

1306519:BIW12 RS05910
gene id: 1306519:BIW12_RS05910
uniprot id: A0A1D9P8W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1306519:BIW12 RS13175
gene id: 1306519:BIW12_RS13175
uniprot id: A0A1D9PCQ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS05080
gene id: 1306519:BIW12_RS05080
uniprot id: A0A1D9P9U2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1306519:BIW12 RS06860
gene id: 1306519:BIW12_RS06860
uniprot id: A0A1D9PA40
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS12380
gene id: 1306519:BIW12_RS12380
uniprot id: A0A1D9PC58
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS16615
gene id: 1306519:BIW12_RS16615
uniprot id: A0A1D9P758
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS01060
gene id: 1306519:BIW12_RS01060
uniprot id: A0A1D9P6F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX15/CtaA family. Type 2 subfamily.
messages: Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
messages: Cell membrane
messages: Interacts with CtaB.
messages: Membrane

1306519:BIW12 RS09765
gene id: 1306519:BIW12_RS09765
uniprot id: A0A1D9PAS2
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1306519:BIW12 RS03865
gene id: 1306519:BIW12_RS03865
uniprot id: A0A1D9P7Z3
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1306519:BIW12 RS15295
gene id: 1306519:BIW12_RS15295
uniprot id: A0A1D9PDQ7
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS12290
gene id: 1306519:BIW12_RS12290
uniprot id: A0A1D9PCU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1306519:BIW12 RS03490
gene id: 1306519:BIW12_RS03490
uniprot id: A0A1D9P7R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1306519:BIW12 RS05510
gene id: 1306519:BIW12_RS05510
uniprot id: A0A1D9P8T7
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

1306519:BIW12 RS01375
gene id: 1306519:BIW12_RS01375
uniprot id: A0A1D9P6H3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1306519:BIW12 RS10385
gene id: 1306519:BIW12_RS10385
uniprot id: A0A1D9PBA3
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS02485
gene id: 1306519:BIW12_RS02485
uniprot id: A0A1D9P717
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1306519:BIW12 RS10330
gene id: 1306519:BIW12_RS10330
uniprot id: A0A1D9PB35
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS02605
gene id: 1306519:BIW12_RS02605
uniprot id: A0A1D9P774
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS01645
gene id: 1306519:BIW12_RS01645
uniprot id: A0A1D9P7F3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1306519:BIW12 RS03405
gene id: 1306519:BIW12_RS03405
uniprot id: A0A1D9P8W9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1306519:BIW12 RS04305
gene id: 1306519:BIW12_RS04305
uniprot id: A0A1D9PE45
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1306519:BIW12 RS03505
gene id: 1306519:BIW12_RS03505
uniprot id: A0A1D9P8Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1306519:BIW12 RS04995
gene id: 1306519:BIW12_RS04995
uniprot id: A0A1D9P8D4
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS04240
gene id: 1306519:BIW12_RS04240
uniprot id: A0A1D9P802
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1306519:BIW12 RS03555
gene id: 1306519:BIW12_RS03555
uniprot id: A0A1D9P8Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1306519:BIW12 RS11430
gene id: 1306519:BIW12_RS11430
uniprot id: A0A1D9PBN4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1306519:BIW12 RS04945
gene id: 1306519:BIW12_RS04945
uniprot id: A0A1D9P8C8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS11530
gene id: 1306519:BIW12_RS11530
uniprot id: A0A1D9PBQ3
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1306519:BIW12 RS13675
gene id: 1306519:BIW12_RS13675
uniprot id: A0A1D9PCU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

1306519:BIW12 RS05120
gene id: 1306519:BIW12_RS05120
uniprot id: A0A1D9P8I0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS09725
gene id: 1306519:BIW12_RS09725
uniprot id: A0A1D9PBI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1306519:BIW12 RS10530
gene id: 1306519:BIW12_RS10530
uniprot id: A0A1D9PBA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS10145
gene id: 1306519:BIW12_RS10145
uniprot id: A0A1D9PB33
names: Similarity
messages: Belongs to the UxaA family.

1306519:BIW12 RS05440
gene id: 1306519:BIW12_RS05440
uniprot id: A0A1D9P8N2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1306519:BIW12 RS09695
gene id: 1306519:BIW12_RS09695
uniprot id: A0A1D9PAV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1306519:BIW12 RS15290
gene id: 1306519:BIW12_RS15290
uniprot id: A0A1D9PDL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1306519:BIW12 RS04990
gene id: 1306519:BIW12_RS04990
uniprot id: A0A1D9P8F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS03375
gene id: 1306519:BIW12_RS03375
uniprot id: A0A1D9P7J4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1306519:BIW12 RS06275
gene id: 1306519:BIW12_RS06275
uniprot id: A0A1D9P922
names: Similarity
messages: Belongs to the DapA family.

1306519:BIW12 RS09835
gene id: 1306519:BIW12_RS09835
uniprot id: A0A1D9PAW7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1306519:BIW12 RS14290
gene id: 1306519:BIW12_RS14290
uniprot id: A0A1D9PDB1
names: Similarity
messages: Belongs to the SUI1 family.

1306519:BIW12 RS07000
gene id: 1306519:BIW12_RS07000
uniprot id: A0A1D9P9F1
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1306519:BIW12 RS15925
gene id: 1306519:BIW12_RS15925
uniprot id: A0A1D9PFG5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS04750
gene id: 1306519:BIW12_RS04750
uniprot id: A0A1D9P8A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1306519:BIW12 RS14990
gene id: 1306519:BIW12_RS14990
uniprot id: A0A1D9PDH7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1306519:BIW12 RS09355
gene id: 1306519:BIW12_RS09355
uniprot id: A0A1D9PAK2
names: Similarity
messages: Belongs to the fabD family.

1306519:BIW12 RS01710
gene id: 1306519:BIW12_RS01710
uniprot id: A0A1D9P6M5
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS02365
gene id: 1306519:BIW12_RS02365
uniprot id: A0A1D9P761
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS11040
gene id: 1306519:BIW12_RS11040
uniprot id: A0A1D9PBN3
names: Subcellular Location Annotation
messages: Mitochondrion

1306519:BIW12 RS00235
gene id: 1306519:BIW12_RS00235
uniprot id: A0A1D9P605
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS02795
gene id: 1306519:BIW12_RS02795
uniprot id: A0A1D9P765
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1306519:BIW12 RS01540
gene id: 1306519:BIW12_RS01540
uniprot id: A0A1D9P6M1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1306519:BIW12 RS03605
gene id: 1306519:BIW12_RS03605
uniprot id: A0A1D9P907
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1306519:BIW12 RS08875
gene id: 1306519:BIW12_RS08875
uniprot id: A0A1D9PAF5
names: Caution
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1306519:BIW12 RS11440
gene id: 1306519:BIW12_RS11440
uniprot id: A0A1D9PBR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1306519:BIW12 RS09865
gene id: 1306519:BIW12_RS09865
uniprot id: A0A1D9PAY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1306519:BIW12 RS01855
gene id: 1306519:BIW12_RS01855
uniprot id: A0A1D9P7J1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12845
gene id: 1306519:BIW12_RS12845
uniprot id: A0A1D9PCI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1306519:BIW12 RS01160
gene id: 1306519:BIW12_RS01160
uniprot id: A0A1D9P6D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS05995
gene id: 1306519:BIW12_RS05995
uniprot id: A0A1D9P8X5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1306519:BIW12 RS03935
gene id: 1306519:BIW12_RS03935
uniprot id: A0A1D9P7T0
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS04640
gene id: 1306519:BIW12_RS04640
uniprot id: A0A1D9P894
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS05820
gene id: 1306519:BIW12_RS05820
uniprot id: A0A1D9P8T0
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

1306519:BIW12 RS01005
gene id: 1306519:BIW12_RS01005
uniprot id: A0A1D9P6E2
names: Similarity
messages: Belongs to the stealth family.

1306519:BIW12 RS00985
gene id: 1306519:BIW12_RS00985
uniprot id: A0A1D9P682
names: Similarity
messages: Belongs to the MQO family.

1306519:BIW12 RS13195
gene id: 1306519:BIW12_RS13195
uniprot id: A0A1D9PCL9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1306519:BIW12 RS14810
gene id: 1306519:BIW12_RS14810
uniprot id: A0A1D9PDL0
names: Similarity
messages: Belongs to the peptidase M1 family.

1306519:BIW12 RS10580
gene id: 1306519:BIW12_RS10580
uniprot id: A0A1D9PB68
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

1306519:BIW12 RS10770
gene id: 1306519:BIW12_RS10770
uniprot id: A0A1D9PBC6
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

1306519:BIW12 RS08205
gene id: 1306519:BIW12_RS08205
uniprot id: A0A1D9PA54
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS09665
gene id: 1306519:BIW12_RS09665
uniprot id: A0A1D9PC44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1306519:BIW12 RS10765
gene id: 1306519:BIW12_RS10765
uniprot id: A0A1D9PBH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1306519:BIW12 RS03460
gene id: 1306519:BIW12_RS03460
uniprot id: A0A1D9P7K1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1306519:BIW12 RS03570
gene id: 1306519:BIW12_RS03570
uniprot id: A0A1D9P7N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1306519:BIW12 RS10820
gene id: 1306519:BIW12_RS10820
uniprot id: A0A1D9PBE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

1306519:BIW12 RS10925
gene id: 1306519:BIW12_RS10925
uniprot id: A0A1D9PBF2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1306519:BIW12 RS14465
gene id: 1306519:BIW12_RS14465
uniprot id: A0A1D9PDE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1306519:BIW12 RS09790
gene id: 1306519:BIW12_RS09790
uniprot id: A0A1D9PC65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS11185
gene id: 1306519:BIW12_RS11185
uniprot id: A0A1D9PCA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1306519:BIW12 RS02165
gene id: 1306519:BIW12_RS02165
uniprot id: A0A1D9P7Q7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1306519:BIW12 RS03465
gene id: 1306519:BIW12_RS03465
uniprot id: A0A1D9P7J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1306519:BIW12 RS06355
gene id: 1306519:BIW12_RS06355
uniprot id: A0A1D9PAH5
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS07835
gene id: 1306519:BIW12_RS07835
uniprot id: A0A1D9P9T6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1306519:BIW12 RS04385
gene id: 1306519:BIW12_RS04385
uniprot id: A0A1D9P9G0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1306519:BIW12 RS12105
gene id: 1306519:BIW12_RS12105
uniprot id: A0A1D9PBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1306519:BIW12 RS02140
gene id: 1306519:BIW12_RS02140
uniprot id: A0A1D9P720
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS03550
gene id: 1306519:BIW12_RS03550
uniprot id: A0A1D9P8E6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1306519:BIW12 RS02775
gene id: 1306519:BIW12_RS02775
uniprot id: A0A1D9P7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1306519:BIW12 RS15715
gene id: 1306519:BIW12_RS15715
uniprot id: A0A1D9PDV1
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS07500
gene id: 1306519:BIW12_RS07500
uniprot id: A0A1D9P9P6
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS14505
gene id: 1306519:BIW12_RS14505
uniprot id: A0A1D9PD88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1306519:BIW12 RS13860
gene id: 1306519:BIW12_RS13860
uniprot id: A0A1D9PCV2
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS14125
gene id: 1306519:BIW12_RS14125
uniprot id: A0A1D9PD17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1306519:BIW12 RS14835
gene id: 1306519:BIW12_RS14835
uniprot id: A0A1D9PDI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1306519:BIW12 RS10535
gene id: 1306519:BIW12_RS10535
uniprot id: A0A1D9PBD2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1306519:BIW12 RS04090
gene id: 1306519:BIW12_RS04090
uniprot id: A0A1D9P7W4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1306519:BIW12 RS08195
gene id: 1306519:BIW12_RS08195
uniprot id: A0A1D9PBE4
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1306519:BIW12 RS05675
gene id: 1306519:BIW12_RS05675
uniprot id: A0A1D9P8U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS10680
gene id: 1306519:BIW12_RS10680
uniprot id: A0A1D9PBA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1306519:BIW12 RS00285
gene id: 1306519:BIW12_RS00285
uniprot id: A0A1D9P613
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1306519:BIW12 RS08775
gene id: 1306519:BIW12_RS08775
uniprot id: A0A1D9PAF8
names: Similarity
messages: Belongs to the SCO1/2 family.

1306519:BIW12 RS02890
gene id: 1306519:BIW12_RS02890
uniprot id: A0A1D9P7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1306519:BIW12 RS12305
gene id: 1306519:BIW12_RS12305
uniprot id: A0A1D9PCA7
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1306519:BIW12 RS04600
gene id: 1306519:BIW12_RS04600
uniprot id: A0A1D9P886
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS13455
gene id: 1306519:BIW12_RS13455
uniprot id: A0A1D9PCP6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1306519:BIW12 RS05870
gene id: 1306519:BIW12_RS05870
uniprot id: A0A1D9P8T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1306519:BIW12 RS02500
gene id: 1306519:BIW12_RS02500
uniprot id: A0A1D9P736
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS07770
gene id: 1306519:BIW12_RS07770
uniprot id: A0A1D9P9U1
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

1306519:BIW12 RS03475
gene id: 1306519:BIW12_RS03475
uniprot id: A0A1D9P7P2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1306519:BIW12 RS15970
gene id: 1306519:BIW12_RS15970
uniprot id: A0A1D9PDZ8
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

1306519:BIW12 RS01305
gene id: 1306519:BIW12_RS01305
uniprot id: A0A1D9P789
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1306519:BIW12 RS14925
gene id: 1306519:BIW12_RS14925
uniprot id: A0A1D9PDE3
names: Similarity
messages: Belongs to the FGGY kinase family.

1306519:BIW12 RS00705
gene id: 1306519:BIW12_RS00705
uniprot id: A0A1D9P686
names: Similarity
messages: Belongs to the pirin family.

1306519:BIW12 RS03610
gene id: 1306519:BIW12_RS03610
uniprot id: A0A1D9P7N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS11705
gene id: 1306519:BIW12_RS11705
uniprot id: A0A1D9PBS7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1306519:BIW12 RS04780
gene id: 1306519:BIW12_RS04780
uniprot id: A0A1D9P8E9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1306519:BIW12 RS14225
gene id: 1306519:BIW12_RS14225
uniprot id: A0A1D9PDS9
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

1306519:BIW12 RS04155
gene id: 1306519:BIW12_RS04155
uniprot id: A0A1D9P840
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1306519:BIW12 RS04220
gene id: 1306519:BIW12_RS04220
uniprot id: A0A1D9P8S3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1306519:BIW12 RS09940
gene id: 1306519:BIW12_RS09940
uniprot id: A0A1D9PBM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1306519:BIW12 RS11105
gene id: 1306519:BIW12_RS11105
uniprot id: A0A1D9PBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1306519:BIW12 RS04580
gene id: 1306519:BIW12_RS04580
uniprot id: A0A1D9PFH1
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS00450
gene id: 1306519:BIW12_RS00450
uniprot id: A0A1D9P656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1306519:BIW12 RS01400
gene id: 1306519:BIW12_RS01400
uniprot id: A0A1D9P6R5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1306519:BIW12 RS11825
gene id: 1306519:BIW12_RS11825
uniprot id: A0A1D9PBU4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1306519:BIW12 RS04310
gene id: 1306519:BIW12_RS04310
uniprot id: A0A1D9P814
names: Similarity
messages: Belongs to the peptidase C40 family.

1306519:BIW12 RS02265
gene id: 1306519:BIW12_RS02265
uniprot id: A0A1D9P708
names: Similarity
messages: Belongs to the DNA photolyase family.

1306519:BIW12 RS11800
gene id: 1306519:BIW12_RS11800
uniprot id: A0A1D9PD64
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS07275
gene id: 1306519:BIW12_RS07275
uniprot id: A0A1D9P9K3
names: Similarity
messages: Belongs to the ArsC family.

1306519:BIW12 RS02115
gene id: 1306519:BIW12_RS02115
uniprot id: A0A1D9P884
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1306519:BIW12 RS06220
gene id: 1306519:BIW12_RS06220
uniprot id: A0A1D9P940
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS07635
gene id: 1306519:BIW12_RS07635
uniprot id: A0A1D9P9S0
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1306519:BIW12 RS05920
gene id: 1306519:BIW12_RS05920
uniprot id: A0A1D9P8V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1306519:BIW12 RS15430
gene id: 1306519:BIW12_RS15430
uniprot id: A0A1D9PEZ8
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS07265
gene id: 1306519:BIW12_RS07265
uniprot id: A0A1D9P9M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1306519:BIW12 RS10480
gene id: 1306519:BIW12_RS10480
uniprot id: A0A1D9PB75
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS16555
gene id: 1306519:BIW12_RS16555
uniprot id: A0A1D9P7Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1306519:BIW12 RS08190
gene id: 1306519:BIW12_RS08190
uniprot id: A0A1D9PAS7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1306519:BIW12 RS11855
gene id: 1306519:BIW12_RS11855
uniprot id: A0A1D9PD74
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

1306519:BIW12 RS02480
gene id: 1306519:BIW12_RS02480
uniprot id: A0A1D9P716
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1306519:BIW12 RS01385
gene id: 1306519:BIW12_RS01385
uniprot id: A0A1D9P6K9
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1306519:BIW12 RS15095
gene id: 1306519:BIW12_RS15095
uniprot id: A0A1D9PDN8
names: Similarity
messages: Belongs to the RutC family.

1306519:BIW12 RS08550
gene id: 1306519:BIW12_RS08550
uniprot id: A0A1D9PFN1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1306519:BIW12 RS04295
gene id: 1306519:BIW12_RS04295
uniprot id: A0A1D9P837
names: Similarity
messages: Belongs to the peptidase S41A family.

1306519:BIW12 RS14795
gene id: 1306519:BIW12_RS14795
uniprot id: A0A1D9PE24
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1306519:BIW12 RS03720
gene id: 1306519:BIW12_RS03720
uniprot id: A0A1D9P7P9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1306519:BIW12 RS04585
gene id: 1306519:BIW12_RS04585
uniprot id: A0A1D9P862
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS09710
gene id: 1306519:BIW12_RS09710
uniprot id: A0A1D9PED2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1306519:BIW12 RS12655
gene id: 1306519:BIW12_RS12655
uniprot id: A0A1D9PCM8
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS11725
gene id: 1306519:BIW12_RS11725
uniprot id: A0A1D9PBZ3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1306519:BIW12 RS08060
gene id: 1306519:BIW12_RS08060
uniprot id: A0A1D9PA00
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS12710
gene id: 1306519:BIW12_RS12710
uniprot id: A0A1D9PCA5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1306519:BIW12 RS06585
gene id: 1306519:BIW12_RS06585
uniprot id: A0A1D9P968
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1306519:BIW12 RS15310
gene id: 1306519:BIW12_RS15310
uniprot id: A0A1D9PDN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1306519:BIW12 RS07240
gene id: 1306519:BIW12_RS07240
uniprot id: A0A1D9P9J1
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1306519:BIW12 RS03495
gene id: 1306519:BIW12_RS03495
uniprot id: A0A1D9P7S0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1306519:BIW12 RS15780
gene id: 1306519:BIW12_RS15780
uniprot id: A0A1D9PDV2
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1306519:BIW12 RS00070
gene id: 1306519:BIW12_RS00070
uniprot id: A0A1D9PDZ0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS03045
gene id: 1306519:BIW12_RS03045
uniprot id: A0A1D9P7D8
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS07135
gene id: 1306519:BIW12_RS07135
uniprot id: A0A1D9P9I1
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS01490
gene id: 1306519:BIW12_RS01490
uniprot id: A0A1D9P6J5
names: Similarity
messages: Belongs to the CarB family.

1306519:BIW12 RS08895
gene id: 1306519:BIW12_RS08895
uniprot id: A0A1D9PAC6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1306519:BIW12 RS13750
gene id: 1306519:BIW12_RS13750
uniprot id: A0A1D9PD07
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS06750
gene id: 1306519:BIW12_RS06750
uniprot id: A0A1D9P9B8
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1306519:BIW12 RS10650
gene id: 1306519:BIW12_RS10650
uniprot id: A0A1D9PBB6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1306519:BIW12 RS07925
gene id: 1306519:BIW12_RS07925
uniprot id: A0A1D9P9Z1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1306519:BIW12 RS10475
gene id: 1306519:BIW12_RS10475
uniprot id: A0A1D9PCJ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1306519:BIW12 RS13990
gene id: 1306519:BIW12_RS13990
uniprot id: A0A1D9PD30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1306519:BIW12 RS01880
gene id: 1306519:BIW12_RS01880
uniprot id: A0A1D9P6X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1306519:BIW12 RS08200
gene id: 1306519:BIW12_RS08200
uniprot id: A0A1D9PA37
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS06760
gene id: 1306519:BIW12_RS06760
uniprot id: A0A1D9PA20
names: Subunit
messages: Homodimer.

1306519:BIW12 RS04170
gene id: 1306519:BIW12_RS04170
uniprot id: A0A1D9P9B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS09830
gene id: 1306519:BIW12_RS09830
uniprot id: A0A1D9PB03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1306519:BIW12 RS11555
gene id: 1306519:BIW12_RS11555
uniprot id: A0A1D9PCG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1306519:BIW12 RS00670
gene id: 1306519:BIW12_RS00670
uniprot id: A0A1D9P652
names: Similarity
messages: Belongs to the HSP15 family.

1306519:BIW12 RS13085
gene id: 1306519:BIW12_RS13085
uniprot id: A0A1D9PCK2
names: Similarity
messages: Belongs to the arginase family.

1306519:BIW12 RS07130
gene id: 1306519:BIW12_RS07130
uniprot id: A0A1D9P9M7
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1306519:BIW12 RS03810
gene id: 1306519:BIW12_RS03810
uniprot id: A0A1D9P7Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1306519:BIW12 RS04460
gene id: 1306519:BIW12_RS04460
uniprot id: A0A1D9PEA2
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS00195
gene id: 1306519:BIW12_RS00195
uniprot id: A0A1D9P658
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

1306519:BIW12 RS00830
gene id: 1306519:BIW12_RS00830
uniprot id: A0A1D9P7M6
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS13865
gene id: 1306519:BIW12_RS13865
uniprot id: A0A1D9PCV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1306519:BIW12 RS12100
gene id: 1306519:BIW12_RS12100
uniprot id: A0A1D9PBZ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1306519:BIW12 RS10755
gene id: 1306519:BIW12_RS10755
uniprot id: A0A1D9PB94
names: Subcellular Location Annotation
messages: Cytoplasm

1306519:BIW12 RS14450
gene id: 1306519:BIW12_RS14450
uniprot id: A0A1D9PEM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1306519:BIW12 RS05645
gene id: 1306519:BIW12_RS05645
uniprot id: A0A1D9P8Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1306519:BIW12 RS08440
gene id: 1306519:BIW12_RS08440
uniprot id: A0A1D9PA48
names: Similarity
messages: Belongs to the universal stress protein A family.

1306519:BIW12 RS00055
gene id: 1306519:BIW12_RS00055
uniprot id: A0A1D9PE83
names: Similarity
messages: Belongs to the SusD family.

1306519:BIW12 RS12115
gene id: 1306519:BIW12_RS12115
uniprot id: A0A1D9PC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1306519:BIW12 RS11170
gene id: 1306519:BIW12_RS11170
uniprot id: A0A1D9PBK8
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1306519:BIW12 RS05190
gene id: 1306519:BIW12_RS05190
uniprot id: A0A1D9P8J1
names: Subcellular Location Annotation
messages: Cytoplasm

1306519:BIW12 RS15770
gene id: 1306519:BIW12_RS15770
uniprot id: A0A1D9PE38
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS05475
gene id: 1306519:BIW12_RS05475
uniprot id: A0A1D9P8M9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1306519:BIW12 RS01250
gene id: 1306519:BIW12_RS01250
uniprot id: A0A1D9P6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1306519:BIW12 RS09635
gene id: 1306519:BIW12_RS09635
uniprot id: A0A1D9PAU0
names: Similarity
messages: Belongs to the NAD synthetase family.

1306519:BIW12 RS09800
gene id: 1306519:BIW12_RS09800
uniprot id: A0A1D9PAY9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1306519:BIW12 RS13920
gene id: 1306519:BIW12_RS13920
uniprot id: A0A1D9PCX1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

1306519:BIW12 RS01960
gene id: 1306519:BIW12_RS01960
uniprot id: A0A1D9P857
names: Similarity
messages: Belongs to the NusB family.

1306519:BIW12 RS15840
gene id: 1306519:BIW12_RS15840
uniprot id: A0A1D9PDW2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1306519:BIW12 RS02295
gene id: 1306519:BIW12_RS02295
uniprot id: A0A1D9P6Z1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1306519:BIW12 RS03445
gene id: 1306519:BIW12_RS03445
uniprot id: A0A1D9P7R0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1306519:BIW12 RS09760
gene id: 1306519:BIW12_RS09760
uniprot id: A0A1D9PAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1306519:BIW12 RS11330
gene id: 1306519:BIW12_RS11330
uniprot id: A0A1D9PBP2
names: Subcellular Location Annotation
messages: Membrane

1306519:BIW12 RS06830
gene id: 1306519:BIW12_RS06830
uniprot id: A0A1D9P9C4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1306519:BIW12 RS02130
gene id: 1306519:BIW12_RS02130
uniprot id: A0A1D9P6W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1306519:BIW12 RS05935
gene id: 1306519:BIW12_RS05935
uniprot id: A0A1D9P8W3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1306519:BIW12 RS00590
gene id: 1306519:BIW12_RS00590
uniprot id: A0A1D9P666
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1306519:BIW12 RS08385
gene id: 1306519:BIW12_RS08385
uniprot id: A0A1D9PA68
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1306519:BIW12 RS11360
gene id: 1306519:BIW12_RS11360
uniprot id: A0A1D9PBT9
names: Similarity
messages: Belongs to the Fur family.

1306519:BIW12 RS05850
gene id: 1306519:BIW12_RS05850
uniprot id: A0A1D9P8W7
names: Similarity
messages: Belongs to the UPF0102 family.

1306519:BIW12 RS08880
gene id: 1306519:BIW12_RS08880
uniprot id: A0A1D9PAH7
names: Similarity
messages: Belongs to the Skp family.

1306519:BIW12 RS10870
gene id: 1306519:BIW12_RS10870
uniprot id: A0A1D9PBB4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1306519:BIW12 RS14295
gene id: 1306519:BIW12_RS14295
uniprot id: A0A1D9PD31
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1306519:BIW12 RS08455
gene id: 1306519:BIW12_RS08455
uniprot id: A0A1D9PA76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1306519:BIW12 RS14180
gene id: 1306519:BIW12_RS14180
uniprot id: A0A1D9PEB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1306519:BIW12 RS11270
gene id: 1306519:BIW12_RS11270
uniprot id: A0A1D9PBN0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1306519:BIW12 RS00255
gene id: 1306519:BIW12_RS00255
uniprot id: A0A1D9P6Q6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.