1301915:JH146 RS00130
gene id: 1301915:JH146_RS00130
uniprot id: A0A076LDJ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

1301915:JH146 RS05220
gene id: 1301915:JH146_RS05220
uniprot id: A0A076LJW7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS05490
gene id: 1301915:JH146_RS05490
uniprot id: A0A076LCI6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1301915:JH146 RS07735
gene id: 1301915:JH146_RS07735
uniprot id: A0A076LIM0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1301915:JH146 RS00515
gene id: 1301915:JH146_RS00515
uniprot id: A0A076LHF2
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1301915:JH146 RS02735
gene id: 1301915:JH146_RS02735
uniprot id: A0A076LFY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

1301915:JH146 RS04535
gene id: 1301915:JH146_RS04535
uniprot id: A0A076LJJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

1301915:JH146 RS07770
gene id: 1301915:JH146_RS07770
uniprot id: A0A076LCW5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate.

1301915:JH146 RS02655
gene id: 1301915:JH146_RS02655
uniprot id: A0A076LEX1
names: Similarity
messages: Belongs to the P(II) protein family.

1301915:JH146 RS02985
gene id: 1301915:JH146_RS02985
uniprot id: A0A076LAN0
names: Similarity
messages: Belongs to the UPF0128 family.

1301915:JH146 RS07130
gene id: 1301915:JH146_RS07130
uniprot id: A0A076LIB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS00580
gene id: 1301915:JH146_RS00580
uniprot id: A0A076LDU5
names: Similarity
messages: Belongs to the UPF0237 family.

1301915:JH146 RS06360
gene id: 1301915:JH146_RS06360
uniprot id: A0A076LD28
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS07100
gene id: 1301915:JH146_RS07100
uniprot id: A0A076LH50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS05095
gene id: 1301915:JH146_RS05095
uniprot id: A0A076LJU1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1301915:JH146 RS05965
gene id: 1301915:JH146_RS05965
uniprot id: A0A076LCX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hemerythrin family.
messages: Monomer.
messages: Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen-binding site contains two iron atoms.

1301915:JH146 RS03040
gene id: 1301915:JH146_RS03040
uniprot id: A0A076LB78
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

1301915:JH146 RS04720
gene id: 1301915:JH146_RS04720
uniprot id: A0A076LBK2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1301915:JH146 RS08270
gene id: 1301915:JH146_RS08270
uniprot id: A0A076LD58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS00230
gene id: 1301915:JH146_RS00230
uniprot id: A0A076LDL9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS06115
gene id: 1301915:JH146_RS06115
uniprot id: A0A076LHV6
names: Similarity
messages: Belongs to the HisA/HisF family.

1301915:JH146 RS02385
gene id: 1301915:JH146_RS02385
uniprot id: A0A076LIH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

1301915:JH146 RS07935
gene id: 1301915:JH146_RS07935
uniprot id: A0A076LHH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1301915:JH146 RS04515
gene id: 1301915:JH146_RS04515
uniprot id: A0A076LBH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

1301915:JH146 RS06815
gene id: 1301915:JH146_RS06815
uniprot id: A0A076LI49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1301915:JH146 RS05515
gene id: 1301915:JH146_RS05515
uniprot id: A0A076LCJ1
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS02255
gene id: 1301915:JH146_RS02255
uniprot id: A0A076LIF0
names: Similarity
messages: Belongs to the UPF0292 family.

1301915:JH146 RS08345
gene id: 1301915:JH146_RS08345
uniprot id: A0A076LLB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1301915:JH146 RS07115
gene id: 1301915:JH146_RS07115
uniprot id: A0A076LCI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1301915:JH146 RS01510
gene id: 1301915:JH146_RS01510
uniprot id: A0A076LAE3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1301915:JH146 RS04000
gene id: 1301915:JH146_RS04000
uniprot id: A0A076LGP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1301915:JH146 RS03640
gene id: 1301915:JH146_RS03640
uniprot id: A0A076LJ51
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1301915:JH146 RS05850
gene id: 1301915:JH146_RS05850
uniprot id: A0A076LGJ6
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

1301915:JH146 RS07075
gene id: 1301915:JH146_RS07075
uniprot id: A0A076LH47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1301915:JH146 RS07645
gene id: 1301915:JH146_RS07645
uniprot id: A0A076LCU6
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

1301915:JH146 RS04310
gene id: 1301915:JH146_RS04310
uniprot id: A0A076LFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1301915:JH146 RS01945
gene id: 1301915:JH146_RS01945
uniprot id: A0A076LA49
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

1301915:JH146 RS04885
gene id: 1301915:JH146_RS04885
uniprot id: A0A076LJQ2
names: Similarity
messages: Belongs to the peptidase U62 family.

1301915:JH146 RS05540
gene id: 1301915:JH146_RS05540
uniprot id: A0A076LCJ7
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1301915:JH146 RS07380
gene id: 1301915:JH146_RS07380
uniprot id: A0A076LKU6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

1301915:JH146 RS07270
gene id: 1301915:JH146_RS07270
uniprot id: A0A076LCL0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

1301915:JH146 RS00510
gene id: 1301915:JH146_RS00510
uniprot id: A0A076LEU6
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS07890
gene id: 1301915:JH146_RS07890
uniprot id: A0A076LIN5
names: Similarity
messages: Belongs to the FrhG family.

1301915:JH146 RS03410
gene id: 1301915:JH146_RS03410
uniprot id: A0A076LJ15
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

1301915:JH146 RS03615
gene id: 1301915:JH146_RS03615
uniprot id: A0A076LJ47
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1301915:JH146 RS04845
gene id: 1301915:JH146_RS04845
uniprot id: A0A076LC91
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS05935
gene id: 1301915:JH146_RS05935
uniprot id: A0A076LC57
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1301915:JH146 RS06750
gene id: 1301915:JH146_RS06750
uniprot id: A0A076LCD0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1301915:JH146 RS07085
gene id: 1301915:JH146_RS07085
uniprot id: A0A076LKP8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1301915:JH146 RS01855
gene id: 1301915:JH146_RS01855
uniprot id: A0A076LFI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1301915:JH146 RS03295
gene id: 1301915:JH146_RS03295
uniprot id: A0A076LAW1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1301915:JH146 RS04655
gene id: 1301915:JH146_RS04655
uniprot id: A0A076LH27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1301915:JH146 RS04435
gene id: 1301915:JH146_RS04435
uniprot id: A0A076LBG2
names: Similarity
messages: Belongs to the peptidase S49 family.

1301915:JH146 RS07810
gene id: 1301915:JH146_RS07810
uniprot id: A0A076LIM6
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS02775
gene id: 1301915:JH146_RS02775
uniprot id: A0A076LAI9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1301915:JH146 RS01710
gene id: 1301915:JH146_RS01710
uniprot id: A0A076LA17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1301915:JH146 RS04980
gene id: 1301915:JH146_RS04980
uniprot id: A0A076LG12
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1301915:JH146 RS06200
gene id: 1301915:JH146_RS06200
uniprot id: A0A076LKF5
names: Similarity
messages: Belongs to the UPF0146 family.

1301915:JH146 RS03470
gene id: 1301915:JH146_RS03470
uniprot id: A0A076LFE2
names: Similarity
messages: Belongs to the UPF0173 family.

1301915:JH146 RS06790
gene id: 1301915:JH146_RS06790
uniprot id: A0A076LI43
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1301915:JH146 RS04670
gene id: 1301915:JH146_RS04670
uniprot id: A0A076LBJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1301915:JH146 RS04240
gene id: 1301915:JH146_RS04240
uniprot id: A0A076LGU2
names: Function
names: Similarity
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

1301915:JH146 RS06010
gene id: 1301915:JH146_RS06010
uniprot id: A0A076LC64
names: Similarity
messages: Belongs to the HMD family.

1301915:JH146 RS03245
gene id: 1301915:JH146_RS03245
uniprot id: A0A076LBE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1301915:JH146 RS06710
gene id: 1301915:JH146_RS06710
uniprot id: A0A076LKK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1301915:JH146 RS01465
gene id: 1301915:JH146_RS01465
uniprot id: A0A076LEB8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1301915:JH146 RS03840
gene id: 1301915:JH146_RS03840
uniprot id: A0A076LGN1
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

1301915:JH146 RS05165
gene id: 1301915:JH146_RS05165
uniprot id: A0A076LHC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1301915:JH146 RS05505
gene id: 1301915:JH146_RS05505
uniprot id: A0A076LK12
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS02730
gene id: 1301915:JH146_RS02730
uniprot id: A0A076LEY5
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1301915:JH146 RS07865
gene id: 1301915:JH146_RS07865
uniprot id: A0A076LIN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1301915:JH146 RS02310
gene id: 1301915:JH146_RS02310
uniprot id: A0A076LIG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

1301915:JH146 RS07080
gene id: 1301915:JH146_RS07080
uniprot id: A0A076LI93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS06525
gene id: 1301915:JH146_RS06525
uniprot id: A0A076LCB1
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

1301915:JH146 RS02270
gene id: 1301915:JH146_RS02270
uniprot id: A0A076LEQ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS01670
gene id: 1301915:JH146_RS01670
uniprot id: A0A076LEF3
names: Similarity
messages: Belongs to the class-I fumarase family.

1301915:JH146 RS07515
gene id: 1301915:JH146_RS07515
uniprot id: A0A076LKW7
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1301915:JH146 RS03415
gene id: 1301915:JH146_RS03415
uniprot id: A0A076LB19
names: Similarity
messages: Belongs to the FwdC/FmdC family.

1301915:JH146 RS07860
gene id: 1301915:JH146_RS07860
uniprot id: A0A076LHG6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1301915:JH146 RS05610
gene id: 1301915:JH146_RS05610
uniprot id: A0A076LBZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1301915:JH146 RS02870
gene id: 1301915:JH146_RS02870
uniprot id: A0A076LIS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

1301915:JH146 RS03520
gene id: 1301915:JH146_RS03520
uniprot id: A0A076LFE8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1301915:JH146 RS01770
gene id: 1301915:JH146_RS01770
uniprot id: A0A076LEH1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1301915:JH146 RS02455
gene id: 1301915:JH146_RS02455
uniprot id: A0A076LES7
names: Similarity
messages: Belongs to the UPF0251 family.

1301915:JH146 RS03060
gene id: 1301915:JH146_RS03060
uniprot id: A0A076LAQ0
names: Subunit
messages: Homotetramer.

1301915:JH146 RS08130
gene id: 1301915:JH146_RS08130
uniprot id: A0A076LIS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1301915:JH146 RS04630
gene id: 1301915:JH146_RS04630
uniprot id: A0A076LH22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1301915:JH146 RS03070
gene id: 1301915:JH146_RS03070
uniprot id: A0A076LB85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

1301915:JH146 RS06580
gene id: 1301915:JH146_RS06580
uniprot id: A0A076LCB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1301915:JH146 RS07175
gene id: 1301915:JH146_RS07175
uniprot id: A0A076LDD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1301915:JH146 RS07335
gene id: 1301915:JH146_RS07335
uniprot id: A0A076LCM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1301915:JH146 RS06280
gene id: 1301915:JH146_RS06280
uniprot id: A0A076LC85
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1301915:JH146 RS07390
gene id: 1301915:JH146_RS07390
uniprot id: A0A076LDH4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS00560
gene id: 1301915:JH146_RS00560
uniprot id: A0A076LEW6
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS04160
gene id: 1301915:JH146_RS04160
uniprot id: A0A076LFN1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1301915:JH146 RS02320
gene id: 1301915:JH146_RS02320
uniprot id: A0A076LAU3
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS05275
gene id: 1301915:JH146_RS05275
uniprot id: A0A076LBU4
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

1301915:JH146 RS00905
gene id: 1301915:JH146_RS00905
uniprot id: A0A076LF54
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1301915:JH146 RS00885
gene id: 1301915:JH146_RS00885
uniprot id: A0A076LHN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1301915:JH146 RS04560
gene id: 1301915:JH146_RS04560
uniprot id: A0A076LJJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1301915:JH146 RS00290
gene id: 1301915:JH146_RS00290
uniprot id: A0A076LH98
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS04835
gene id: 1301915:JH146_RS04835
uniprot id: A0A076LJP2
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1301915:JH146 RS00245
gene id: 1301915:JH146_RS00245
uniprot id: A0A076L999
names: Similarity
messages: Belongs to the UPF0047 family.

1301915:JH146 RS06650
gene id: 1301915:JH146_RS06650
uniprot id: A0A076LGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

1301915:JH146 RS02920
gene id: 1301915:JH146_RS02920
uniprot id: A0A076LIT5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS03360
gene id: 1301915:JH146_RS03360
uniprot id: A0A076LJ02
names: Similarity
messages: Belongs to the AOR/FOR family.

1301915:JH146 RS06180
gene id: 1301915:JH146_RS06180
uniprot id: A0A076LC75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS07675
gene id: 1301915:JH146_RS07675
uniprot id: A0A076LDN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS06800
gene id: 1301915:JH146_RS06800
uniprot id: A0A076LCD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1301915:JH146 RS06025
gene id: 1301915:JH146_RS06025
uniprot id: A0A076LHV3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

1301915:JH146 RS03550
gene id: 1301915:JH146_RS03550
uniprot id: A0A076LFF1
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1301915:JH146 RS06230
gene id: 1301915:JH146_RS06230
uniprot id: A0A076LC80
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1301915:JH146 RS00060
gene id: 1301915:JH146_RS00060
uniprot id: A0A076LEM7
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

1301915:JH146 RS07945
gene id: 1301915:JH146_RS07945
uniprot id: A0A076LL50
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1301915:JH146 RS03285
gene id: 1301915:JH146_RS03285
uniprot id: A0A076LG88
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS02815
gene id: 1301915:JH146_RS02815
uniprot id: A0A076LIR7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1301915:JH146 RS02670
gene id: 1301915:JH146_RS02670
uniprot id: A0A076LAH5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

1301915:JH146 RS03525
gene id: 1301915:JH146_RS03525
uniprot id: A0A076LGH9
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1301915:JH146 RS07465
gene id: 1301915:JH146_RS07465
uniprot id: A0A076LKV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS08400
gene id: 1301915:JH146_RS08400
uniprot id: A0A076LD81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

1301915:JH146 RS04450
gene id: 1301915:JH146_RS04450
uniprot id: A0A076LGY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

1301915:JH146 RS02860
gene id: 1301915:JH146_RS02860
uniprot id: A0A076LF06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1301915:JH146 RS07200
gene id: 1301915:JH146_RS07200
uniprot id: A0A076LDD9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1301915:JH146 RS03890
gene id: 1301915:JH146_RS03890
uniprot id: A0A076LFK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1301915:JH146 RS03290
gene id: 1301915:JH146_RS03290
uniprot id: A0A076LIY8
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS02705
gene id: 1301915:JH146_RS02705
uniprot id: A0A076LEY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1301915:JH146 RS04290
gene id: 1301915:JH146_RS04290
uniprot id: A0A076LGV3
names: Similarity
messages: Belongs to the UPF0235 family.

1301915:JH146 RS02035
gene id: 1301915:JH146_RS02035
uniprot id: A0A076LFL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1301915:JH146 RS04135
gene id: 1301915:JH146_RS04135
uniprot id: A0A076LGS3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1301915:JH146 RS04185
gene id: 1301915:JH146_RS04185
uniprot id: A0A076LFN6
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1301915:JH146 RS03015
gene id: 1301915:JH146_RS03015
uniprot id: A0A076LB72
names: Similarity
messages: Belongs to the UPF0273 family.

1301915:JH146 RS04520
gene id: 1301915:JH146_RS04520
uniprot id: A0A076LC46
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1301915:JH146 RS06980
gene id: 1301915:JH146_RS06980
uniprot id: A0A076LKN7
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1301915:JH146 RS05580
gene id: 1301915:JH146_RS05580
uniprot id: A0A076LK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS03590
gene id: 1301915:JH146_RS03590
uniprot id: A0A076LJ44
names: Similarity
messages: Belongs to the ComB family.

1301915:JH146 RS03085
gene id: 1301915:JH146_RS03085
uniprot id: A0A076LIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1301915:JH146 RS00540
gene id: 1301915:JH146_RS00540
uniprot id: A0A076LHF8
names: Similarity
messages: Belongs to the UPF0201 family.

1301915:JH146 RS05855
gene id: 1301915:JH146_RS05855
uniprot id: A0A076LHP0
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

1301915:JH146 RS05330
gene id: 1301915:JH146_RS05330
uniprot id: A0A076LCG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS05390
gene id: 1301915:JH146_RS05390
uniprot id: A0A076LHG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1301915:JH146 RS01145
gene id: 1301915:JH146_RS01145
uniprot id: A0A076LHS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1301915:JH146 RS01645
gene id: 1301915:JH146_RS01645
uniprot id: A0A076LEE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS03975
gene id: 1301915:JH146_RS03975
uniprot id: A0A076LGP7
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS01545
gene id: 1301915:JH146_RS01545
uniprot id: A0A076LFC8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1301915:JH146 RS02880
gene id: 1301915:JH146_RS02880
uniprot id: A0A076LB48
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1301915:JH146 RS05440
gene id: 1301915:JH146_RS05440
uniprot id: A0A076LCH6
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS05270
gene id: 1301915:JH146_RS05270
uniprot id: A0A076LJX5
names: Similarity
messages: Belongs to the HdrC family.

1301915:JH146 RS06195
gene id: 1301915:JH146_RS06195
uniprot id: A0A076LHW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1301915:JH146 RS02100
gene id: 1301915:JH146_RS02100
uniprot id: A0A076LAP8
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

1301915:JH146 RS04125
gene id: 1301915:JH146_RS04125
uniprot id: A0A076LBX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS07940
gene id: 1301915:JH146_RS07940
uniprot id: A0A076LIP3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1301915:JH146 RS01750
gene id: 1301915:JH146_RS01750
uniprot id: A0A076LFH0
names: Similarity
messages: Belongs to the AAA ATPase family.

1301915:JH146 RS08435
gene id: 1301915:JH146_RS08435
uniprot id: A0A076LHS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1301915:JH146 RS02780
gene id: 1301915:JH146_RS02780
uniprot id: A0A076LB28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

1301915:JH146 RS02415
gene id: 1301915:JH146_RS02415
uniprot id: A0A076LAD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1301915:JH146 RS07415
gene id: 1301915:JH146_RS07415
uniprot id: A0A076LDH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS01155
gene id: 1301915:JH146_RS01155
uniprot id: A0A076LA89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1301915:JH146 RS04415
gene id: 1301915:JH146_RS04415
uniprot id: A0A076LFS2
names: Similarity
messages: Belongs to the UPF0305 family.

1301915:JH146 RS01245
gene id: 1301915:JH146_RS01245
uniprot id: A0A076LHU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1301915:JH146 RS05875
gene id: 1301915:JH146_RS05875
uniprot id: A0A076LGK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

1301915:JH146 RS03740
gene id: 1301915:JH146_RS03740
uniprot id: A0A076LJ69
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

1301915:JH146 RS07575
gene id: 1301915:JH146_RS07575
uniprot id: A0A076LDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1301915:JH146 RS08440
gene id: 1301915:JH146_RS08440
uniprot id: A0A076LIX3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1301915:JH146 RS08405
gene id: 1301915:JH146_RS08405
uniprot id: A0A076LE31
names: Similarity
messages: Belongs to the MoaB/Mog family.

1301915:JH146 RS00835
gene id: 1301915:JH146_RS00835
uniprot id: A0A076LF40
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1301915:JH146 RS08085
gene id: 1301915:JH146_RS08085
uniprot id: A0A076LDW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

1301915:JH146 RS06665
gene id: 1301915:JH146_RS06665
uniprot id: A0A076LCC1
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

1301915:JH146 RS00575
gene id: 1301915:JH146_RS00575
uniprot id: A0A076L9U2
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

1301915:JH146 RS04865
gene id: 1301915:JH146_RS04865
uniprot id: A0A076LBL9
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

1301915:JH146 RS03905
gene id: 1301915:JH146_RS03905
uniprot id: A0A076LB90
names: Similarity
messages: Belongs to the pyruvate kinase family.

1301915:JH146 RS07760
gene id: 1301915:JH146_RS07760
uniprot id: A0A076LIM2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1301915:JH146 RS08375
gene id: 1301915:JH146_RS08375
uniprot id: A0A076LD77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1301915:JH146 RS00815
gene id: 1301915:JH146_RS00815
uniprot id: A0A076LHM2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1301915:JH146 RS04060
gene id: 1301915:JH146_RS04060
uniprot id: A0A076LJA9
names: Function
messages: Part of a potassium transport system.

1301915:JH146 RS06355
gene id: 1301915:JH146_RS06355
uniprot id: A0A076LC92
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

1301915:JH146 RS06585
gene id: 1301915:JH146_RS06585
uniprot id: A0A076LD63
names: Similarity
messages: Belongs to the GARS family.

1301915:JH146 RS05485
gene id: 1301915:JH146_RS05485
uniprot id: A0A076LBX7
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS07355
gene id: 1301915:JH146_RS07355
uniprot id: A0A076LKU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1301915:JH146 RS07650
gene id: 1301915:JH146_RS07650
uniprot id: A0A076LDM8
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

1301915:JH146 RS00625
gene id: 1301915:JH146_RS00625
uniprot id: A0A076LDV8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1301915:JH146 RS03815
gene id: 1301915:JH146_RS03815
uniprot id: A0A076LJ80
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

1301915:JH146 RS07235
gene id: 1301915:JH146_RS07235
uniprot id: A0A076LID6
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

1301915:JH146 RS02805
gene id: 1301915:JH146_RS02805
uniprot id: A0A076LEZ8
names: Similarity
messages: Belongs to the HerA family.

1301915:JH146 RS04740
gene id: 1301915:JH146_RS04740
uniprot id: A0A076LJM6
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1301915:JH146 RS01835
gene id: 1301915:JH146_RS01835
uniprot id: A0A076LI67
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

1301915:JH146 RS03135
gene id: 1301915:JH146_RS03135
uniprot id: A0A076LIW6
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

1301915:JH146 RS05455
gene id: 1301915:JH146_RS05455
uniprot id: A0A076LK07
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS07180
gene id: 1301915:JH146_RS07180
uniprot id: A0A076LH61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

1301915:JH146 RS06265
gene id: 1301915:JH146_RS06265
uniprot id: A0A076LGU6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS02355
gene id: 1301915:JH146_RS02355
uniprot id: A0A076LFS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1301915:JH146 RS07410
gene id: 1301915:JH146_RS07410
uniprot id: A0A076LCP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1301915:JH146 RS07630
gene id: 1301915:JH146_RS07630
uniprot id: A0A076LHD2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

1301915:JH146 RS07850
gene id: 1301915:JH146_RS07850
uniprot id: A0A076LCX9
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

1301915:JH146 RS05055
gene id: 1301915:JH146_RS05055
uniprot id: A0A076LCC3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

1301915:JH146 RS06480
gene id: 1301915:JH146_RS06480
uniprot id: A0A076LGX6
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS00460
gene id: 1301915:JH146_RS00460
uniprot id: A0A076LET4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1301915:JH146 RS01615
gene id: 1301915:JH146_RS01615
uniprot id: A0A076LAF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1301915:JH146 RS05985
gene id: 1301915:JH146_RS05985
uniprot id: A0A076LC61
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1301915:JH146 RS04635
gene id: 1301915:JH146_RS04635
uniprot id: A0A076LJK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1301915:JH146 RS02315
gene id: 1301915:JH146_RS02315
uniprot id: A0A076LAA9
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS00585
gene id: 1301915:JH146_RS00585
uniprot id: A0A076LEX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

1301915:JH146 RS01655
gene id: 1301915:JH146_RS01655
uniprot id: A0A076LI31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

1301915:JH146 RS00070
gene id: 1301915:JH146_RS00070
uniprot id: A0A076L969
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1301915:JH146 RS02570
gene id: 1301915:JH146_RS02570
uniprot id: A0A076LAF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1301915:JH146 RS01650
gene id: 1301915:JH146_RS01650
uniprot id: A0A076LFF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

1301915:JH146 RS04470
gene id: 1301915:JH146_RS04470
uniprot id: A0A076LFT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1301915:JH146 RS03885
gene id: 1301915:JH146_RS03885
uniprot id: A0A076LBT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS07360
gene id: 1301915:JH146_RS07360
uniprot id: A0A076LCM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS06770
gene id: 1301915:JH146_RS06770
uniprot id: A0A076LKL4
names: Similarity
messages: Belongs to the MEMO1 family.

1301915:JH146 RS06185
gene id: 1301915:JH146_RS06185
uniprot id: A0A076LD02
names: Similarity
messages: Belongs to the PDCD5 family.

1301915:JH146 RS00700
gene id: 1301915:JH146_RS00700
uniprot id: A0A076LDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1301915:JH146 RS02000
gene id: 1301915:JH146_RS02000
uniprot id: A0A076LAM7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1301915:JH146 RS07140
gene id: 1301915:JH146_RS07140
uniprot id: A0A076LCJ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1301915:JH146 RS02115
gene id: 1301915:JH146_RS02115
uniprot id: A0A076LEN7
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS06100
gene id: 1301915:JH146_RS06100
uniprot id: A0A076LC68
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1301915:JH146 RS06130
gene id: 1301915:JH146_RS06130
uniprot id: A0A076LCZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1301915:JH146 RS07955
gene id: 1301915:JH146_RS07955
uniprot id: A0A076LDT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

1301915:JH146 RS01505
gene id: 1301915:JH146_RS01505
uniprot id: A0A076L9Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1301915:JH146 RS01345
gene id: 1301915:JH146_RS01345
uniprot id: A0A076LHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1301915:JH146 RS08295
gene id: 1301915:JH146_RS08295
uniprot id: A0A076LD62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS02120
gene id: 1301915:JH146_RS02120
uniprot id: A0A076LFN5
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS02195
gene id: 1301915:JH146_RS02195
uniprot id: A0A076LFP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1301915:JH146 RS06345
gene id: 1301915:JH146_RS06345
uniprot id: A0A076LHY2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

1301915:JH146 RS07590
gene id: 1301915:JH146_RS07590
uniprot id: A0A076LKY0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1301915:JH146 RS01920
gene id: 1301915:JH146_RS01920
uniprot id: A0A076LA45
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1301915:JH146 RS04325
gene id: 1301915:JH146_RS04325
uniprot id: A0A076LBE9
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

1301915:JH146 RS01430
gene id: 1301915:JH146_RS01430
uniprot id: A0A076L9X3
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS03090
gene id: 1301915:JH146_RS03090
uniprot id: A0A076LAQ6
names: Similarity
messages: Belongs to the UPF0288 family.

1301915:JH146 RS02425
gene id: 1301915:JH146_RS02425
uniprot id: A0A076LES3
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1301915:JH146 RS01540
gene id: 1301915:JH146_RS01540
uniprot id: A0A076LED3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1301915:JH146 RS02615
gene id: 1301915:JH146_RS02615
uniprot id: A0A076LIM9
names: Similarity
messages: Belongs to the FUN14 family.

1301915:JH146 RS00850
gene id: 1301915:JH146_RS00850
uniprot id: A0A076LA35
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

1301915:JH146 RS02200
gene id: 1301915:JH146_RS02200
uniprot id: A0A076LIE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1301915:JH146 RS02205
gene id: 1301915:JH146_RS02205
uniprot id: A0A076LA87
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1301915:JH146 RS02475
gene id: 1301915:JH146_RS02475
uniprot id: A0A076LAX8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1301915:JH146 RS05170
gene id: 1301915:JH146_RS05170
uniprot id: A0A076LJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1301915:JH146 RS07205
gene id: 1301915:JH146_RS07205
uniprot id: A0A076LH65
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1301915:JH146 RS07665
gene id: 1301915:JH146_RS07665
uniprot id: A0A076LKZ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS04620
gene id: 1301915:JH146_RS04620
uniprot id: A0A076LC60
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS02700
gene id: 1301915:JH146_RS02700
uniprot id: A0A076LB15
names: Similarity
messages: Belongs to the UPF0282 family.

1301915:JH146 RS03685
gene id: 1301915:JH146_RS03685
uniprot id: A0A076LJ58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS00655
gene id: 1301915:JH146_RS00655
uniprot id: A0A076LEZ3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

1301915:JH146 RS04900
gene id: 1301915:JH146_RS04900
uniprot id: A0A076LFZ8
names: Similarity
messages: Belongs to the HypD family.

1301915:JH146 RS03170
gene id: 1301915:JH146_RS03170
uniprot id: A0A076LG67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1301915:JH146 RS01890
gene id: 1301915:JH146_RS01890
uniprot id: A0A076LI76
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

1301915:JH146 RS06985
gene id: 1301915:JH146_RS06985
uniprot id: A0A076LCG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1301915:JH146 RS00345
gene id: 1301915:JH146_RS00345
uniprot id: A0A076L9B7
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

1301915:JH146 RS08380
gene id: 1301915:JH146_RS08380
uniprot id: A0A076LE22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1301915:JH146 RS00810
gene id: 1301915:JH146_RS00810
uniprot id: A0A076LF38
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1301915:JH146 RS00250
gene id: 1301915:JH146_RS00250
uniprot id: A0A076L9L3
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS06510
gene id: 1301915:JH146_RS06510
uniprot id: A0A076LI04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1301915:JH146 RS04045
gene id: 1301915:JH146_RS04045
uniprot id: A0A076LBW2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1301915:JH146 RS04390
gene id: 1301915:JH146_RS04390
uniprot id: A0A076LFR7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1301915:JH146 RS05355
gene id: 1301915:JH146_RS05355
uniprot id: A0A076LCG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS06125
gene id: 1301915:JH146_RS06125
uniprot id: A0A076LC71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1301915:JH146 RS08000
gene id: 1301915:JH146_RS08000
uniprot id: A0A076LD09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1301915:JH146 RS01340
gene id: 1301915:JH146_RS01340
uniprot id: A0A076LFA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS07920
gene id: 1301915:JH146_RS07920
uniprot id: A0A076LL44
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS02890
gene id: 1301915:JH146_RS02890
uniprot id: A0A076LG11
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1301915:JH146 RS04465
gene id: 1301915:JH146_RS04465
uniprot id: A0A076LC37
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1301915:JH146 RS02660
gene id: 1301915:JH146_RS02660
uniprot id: A0A076LFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS06350
gene id: 1301915:JH146_RS06350
uniprot id: A0A076LKH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1301915:JH146 RS08340
gene id: 1301915:JH146_RS08340
uniprot id: A0A076LIV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1301915:JH146 RS01730
gene id: 1301915:JH146_RS01730
uniprot id: A0A076LI47
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS07160
gene id: 1301915:JH146_RS07160
uniprot id: A0A076LKQ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1301915:JH146 RS02340
gene id: 1301915:JH146_RS02340
uniprot id: A0A076LAB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1301915:JH146 RS05070
gene id: 1301915:JH146_RS05070
uniprot id: A0A076LJT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

1301915:JH146 RS03035
gene id: 1301915:JH146_RS03035
uniprot id: A0A076LAP4
names: Similarity
messages: Belongs to the NodU/CmcH family.

1301915:JH146 RS08105
gene id: 1301915:JH146_RS08105
uniprot id: A0A076LD27
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1301915:JH146 RS08215
gene id: 1301915:JH146_RS08215
uniprot id: A0A076LD47
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS07620
gene id: 1301915:JH146_RS07620
uniprot id: A0A076LCU3
names: Similarity
messages: Belongs to the UPF0210 family.

1301915:JH146 RS01515
gene id: 1301915:JH146_RS01515
uniprot id: A0A076LEC9
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS01640
gene id: 1301915:JH146_RS01640
uniprot id: A0A076LAG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS06590
gene id: 1301915:JH146_RS06590
uniprot id: A0A076LGY7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1301915:JH146 RS04075
gene id: 1301915:JH146_RS04075
uniprot id: A0A076LFM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1301915:JH146 RS01230
gene id: 1301915:JH146_RS01230
uniprot id: A0A076LAA1
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1301915:JH146 RS04680
gene id: 1301915:JH146_RS04680
uniprot id: A0A076LFW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1301915:JH146 RS05680
gene id: 1301915:JH146_RS05680
uniprot id: A0A076LK38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1301915:JH146 RS08050
gene id: 1301915:JH146_RS08050
uniprot id: A0A076LL72
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS08135
gene id: 1301915:JH146_RS08135
uniprot id: A0A076LL91
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1301915:JH146 RS07135
gene id: 1301915:JH146_RS07135
uniprot id: A0A076LKQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1301915:JH146 RS08320
gene id: 1301915:JH146_RS08320
uniprot id: A0A076LLA9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1301915:JH146 RS03810
gene id: 1301915:JH146_RS03810
uniprot id: A0A076LGM8
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

1301915:JH146 RS06425
gene id: 1301915:JH146_RS06425
uniprot id: A0A076LKI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

1301915:JH146 RS07165
gene id: 1301915:JH146_RS07165
uniprot id: A0A076LCJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1301915:JH146 RS04945
gene id: 1301915:JH146_RS04945
uniprot id: A0A076LBM9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1301915:JH146 RS07755
gene id: 1301915:JH146_RS07755
uniprot id: A0A076LHE9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1301915:JH146 RS07790
gene id: 1301915:JH146_RS07790
uniprot id: A0A076LL23
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1301915:JH146 RS02015
gene id: 1301915:JH146_RS02015
uniprot id: A0A076LIA3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1301915:JH146 RS07350
gene id: 1301915:JH146_RS07350
uniprot id: A0A076LIG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1301915:JH146 RS02435
gene id: 1301915:JH146_RS02435
uniprot id: A0A076LFT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1301915:JH146 RS04545
gene id: 1301915:JH146_RS04545
uniprot id: A0A076LC49
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1301915:JH146 RS06020
gene id: 1301915:JH146_RS06020
uniprot id: A0A076LGR2
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1301915:JH146 RS01300
gene id: 1301915:JH146_RS01300
uniprot id: A0A076L9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS06150
gene id: 1301915:JH146_RS06150
uniprot id: A0A076LC73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1301915:JH146 RS07070
gene id: 1301915:JH146_RS07070
uniprot id: A0A076LDC5
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1301915:JH146 RS03125
gene id: 1301915:JH146_RS03125
uniprot id: A0A076LF53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1301915:JH146 RS04715
gene id: 1301915:JH146_RS04715
uniprot id: A0A076LJM1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1301915:JH146 RS00465
gene id: 1301915:JH146_RS00465
uniprot id: A0A076LHE0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1301915:JH146 RS02690
gene id: 1301915:JH146_RS02690
uniprot id: A0A076LIP5
names: Similarity
messages: Belongs to the UPF0179 family.

1301915:JH146 RS06705
gene id: 1301915:JH146_RS06705
uniprot id: A0A076LI33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1301915:JH146 RS00730
gene id: 1301915:JH146_RS00730
uniprot id: A0A076LF11
names: Similarity
messages: Belongs to the UPF0280 family.

1301915:JH146 RS00280
gene id: 1301915:JH146_RS00280
uniprot id: A0A076LDN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

1301915:JH146 RS01560
gene id: 1301915:JH146_RS01560
uniprot id: A0A076L9Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

1301915:JH146 RS08125
gene id: 1301915:JH146_RS08125
uniprot id: A0A076LHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1301915:JH146 RS04700
gene id: 1301915:JH146_RS04700
uniprot id: A0A076LC70
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1301915:JH146 RS00635
gene id: 1301915:JH146_RS00635
uniprot id: A0A076LHH4
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1301915:JH146 RS03355
gene id: 1301915:JH146_RS03355
uniprot id: A0A076LGD6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

1301915:JH146 RS06540
gene id: 1301915:JH146_RS06540
uniprot id: A0A076LI07
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1301915:JH146 RS02610
gene id: 1301915:JH146_RS02610
uniprot id: A0A076LFW3
names: Similarity
messages: Belongs to the UPF0212 family.

1301915:JH146 RS03595
gene id: 1301915:JH146_RS03595
uniprot id: A0A076LB45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1301915:JH146 RS08370
gene id: 1301915:JH146_RS08370
uniprot id: A0A076LLB6
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

1301915:JH146 RS05910
gene id: 1301915:JH146_RS05910
uniprot id: A0A076LK83
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1301915:JH146 RS05915
gene id: 1301915:JH146_RS05915
uniprot id: A0A076LC45
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1301915:JH146 RS06715
gene id: 1301915:JH146_RS06715
uniprot id: A0A076LCC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1301915:JH146 RS06290
gene id: 1301915:JH146_RS06290
uniprot id: A0A076LGV0
names: Similarity
messages: Belongs to the DEAD box helicase family.

1301915:JH146 RS02160
gene id: 1301915:JH146_RS02160
uniprot id: A0A076LAR0
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

1301915:JH146 RS01685
gene id: 1301915:JH146_RS01685
uniprot id: A0A076LA15
names: Similarity
messages: Belongs to the UPF0107 family.

1301915:JH146 RS08245
gene id: 1301915:JH146_RS08245
uniprot id: A0A076LDZ4
names: Similarity
messages: Belongs to the HupF/HypC family.

1301915:JH146 RS00595
gene id: 1301915:JH146_RS00595
uniprot id: A0A076L9V1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS02675
gene id: 1301915:JH146_RS02675
uniprot id: A0A076LB12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1301915:JH146 RS08275
gene id: 1301915:JH146_RS08275
uniprot id: A0A076LDZ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1301915:JH146 RS07000
gene id: 1301915:JH146_RS07000
uniprot id: A0A076LI77
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS06435
gene id: 1301915:JH146_RS06435
uniprot id: A0A076LD38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1301915:JH146 RS05800
gene id: 1301915:JH146_RS05800
uniprot id: A0A076LHM8
names: Similarity
messages: Belongs to the DsrF/TusC family.

1301915:JH146 RS08355
gene id: 1301915:JH146_RS08355
uniprot id: A0A076LE14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1301915:JH146 RS07440
gene id: 1301915:JH146_RS07440
uniprot id: A0A076LKV4
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

1301915:JH146 RS06470
gene id: 1301915:JH146_RS06470
uniprot id: A0A076LCA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1301915:JH146 RS06495
gene id: 1301915:JH146_RS06495
uniprot id: A0A076LCA7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

1301915:JH146 RS01140
gene id: 1301915:JH146_RS01140
uniprot id: A0A076LF86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

1301915:JH146 RS06730
gene id: 1301915:JH146_RS06730
uniprot id: A0A076LH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS03860
gene id: 1301915:JH146_RS03860
uniprot id: A0A076LBT0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1301915:JH146 RS07450
gene id: 1301915:JH146_RS07450
uniprot id: A0A076LDI3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1301915:JH146 RS07185
gene id: 1301915:JH146_RS07185
uniprot id: A0A076LIC5
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS02560
gene id: 1301915:JH146_RS02560
uniprot id: A0A076LFV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1301915:JH146 RS04040
gene id: 1301915:JH146_RS04040
uniprot id: A0A076LBB4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1301915:JH146 RS07110
gene id: 1301915:JH146_RS07110
uniprot id: A0A076LKQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1301915:JH146 RS02715
gene id: 1301915:JH146_RS02715
uniprot id: A0A076LIP8
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1301915:JH146 RS06380
gene id: 1301915:JH146_RS06380
uniprot id: A0A076LC94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1301915:JH146 RS01085
gene id: 1301915:JH146_RS01085
uniprot id: A0A076LE55
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS04500
gene id: 1301915:JH146_RS04500
uniprot id: A0A076LFT6
names: Similarity
messages: Belongs to the glutaredoxin family.

1301915:JH146 RS00010
gene id: 1301915:JH146_RS00010
uniprot id: A0A076LEM2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1301915:JH146 RS07855
gene id: 1301915:JH146_RS07855
uniprot id: A0A076LDR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1301915:JH146 RS08170
gene id: 1301915:JH146_RS08170
uniprot id: A0A076LDX9
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1301915:JH146 RS06095
gene id: 1301915:JH146_RS06095
uniprot id: A0A076LKE5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS02030
gene id: 1301915:JH146_RS02030
uniprot id: A0A076LEM0
names: Subunit
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1301915:JH146 RS04830
gene id: 1301915:JH146_RS04830
uniprot id: A0A076LH72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1301915:JH146 RS06110
gene id: 1301915:JH146_RS06110
uniprot id: A0A076LGS2
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1301915:JH146 RS07640
gene id: 1301915:JH146_RS07640
uniprot id: A0A076LKZ3
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

1301915:JH146 RS00865
gene id: 1301915:JH146_RS00865
uniprot id: A0A076LHN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1301915:JH146 RS05280
gene id: 1301915:JH146_RS05280
uniprot id: A0A076LCG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS03250
gene id: 1301915:JH146_RS03250
uniprot id: A0A076LF75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1301915:JH146 RS07835
gene id: 1301915:JH146_RS07835
uniprot id: A0A076LHG3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1301915:JH146 RS03985
gene id: 1301915:JH146_RS03985
uniprot id: A0A076LBA4
names: Similarity
messages: Belongs to the DtxR/MntR family.

1301915:JH146 RS08410
gene id: 1301915:JH146_RS08410
uniprot id: A0A076LHR5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1301915:JH146 RS00120
gene id: 1301915:JH146_RS00120
uniprot id: A0A076L978
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1301915:JH146 RS04575
gene id: 1301915:JH146_RS04575
uniprot id: A0A076LFU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1301915:JH146 RS01725
gene id: 1301915:JH146_RS01725
uniprot id: A0A076LFG6
names: Similarity
messages: Belongs to the MCM family.

1301915:JH146 RS00500
gene id: 1301915:JH146_RS00500
uniprot id: A0A076L9S0
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS06420
gene id: 1301915:JH146_RS06420
uniprot id: A0A076LHZ1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1301915:JH146 RS01680
gene id: 1301915:JH146_RS01680
uniprot id: A0A076LI37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1301915:JH146 RS01995
gene id: 1301915:JH146_RS01995
uniprot id: A0A076LA55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1301915:JH146 RS02575
gene id: 1301915:JH146_RS02575
uniprot id: A0A076LAZ6
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

1301915:JH146 RS00645
gene id: 1301915:JH146_RS00645
uniprot id: A0A076L9W5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS04960
gene id: 1301915:JH146_RS04960
uniprot id: A0A076LH93
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1301915:JH146 RS01880
gene id: 1301915:JH146_RS01880
uniprot id: A0A076LEJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1301915:JH146 RS05720
gene id: 1301915:JH146_RS05720
uniprot id: A0A076LGG3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1301915:JH146 RS06695
gene id: 1301915:JH146_RS06695
uniprot id: A0A076LD75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1301915:JH146 RS05865
gene id: 1301915:JH146_RS05865
uniprot id: A0A076LC36
names: Similarity
messages: Belongs to the FrhG family.

1301915:JH146 RS02375
gene id: 1301915:JH146_RS02375
uniprot id: A0A076LER7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

1301915:JH146 RS05375
gene id: 1301915:JH146_RS05375
uniprot id: A0A076LBW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1301915:JH146 RS07495
gene id: 1301915:JH146_RS07495
uniprot id: A0A076LCR9
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1301915:JH146 RS02190
gene id: 1301915:JH146_RS02190
uniprot id: A0A076LEP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1301915:JH146 RS05255
gene id: 1301915:JH146_RS05255
uniprot id: A0A076LCF5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1301915:JH146 RS06900
gene id: 1301915:JH146_RS06900
uniprot id: A0A076LCF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1301915:JH146 RS02210
gene id: 1301915:JH146_RS02210
uniprot id: A0A076LAS0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

1301915:JH146 RS07345
gene id: 1301915:JH146_RS07345
uniprot id: A0A076LH90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1301915:JH146 RS07870
gene id: 1301915:JH146_RS07870
uniprot id: A0A076LL37
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1301915:JH146 RS07280
gene id: 1301915:JH146_RS07280
uniprot id: A0A076LH76
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1301915:JH146 RS01930
gene id: 1301915:JH146_RS01930
uniprot id: A0A076LEJ9
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS00415
gene id: 1301915:JH146_RS00415
uniprot id: A0A076LHC7
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS04880
gene id: 1301915:JH146_RS04880
uniprot id: A0A076LH80
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1301915:JH146 RS07155
gene id: 1301915:JH146_RS07155
uniprot id: A0A076LIB9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1301915:JH146 RS03875
gene id: 1301915:JH146_RS03875
uniprot id: A0A076LJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

1301915:JH146 RS01295
gene id: 1301915:JH146_RS01295
uniprot id: A0A076LHW4
names: Similarity
messages: Belongs to the P(II) protein family.

1301915:JH146 RS03540
gene id: 1301915:JH146_RS03540
uniprot id: A0A076LB37
names: Similarity
messages: Belongs to the UPF0215 family.

1301915:JH146 RS01865
gene id: 1301915:JH146_RS01865
uniprot id: A0A076LA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1301915:JH146 RS06260
gene id: 1301915:JH146_RS06260
uniprot id: A0A076LD15
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1301915:JH146 RS08390
gene id: 1301915:JH146_RS08390
uniprot id: A0A076LIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1301915:JH146 RS04165
gene id: 1301915:JH146_RS04165
uniprot id: A0A076LGS8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1301915:JH146 RS04950
gene id: 1301915:JH146_RS04950
uniprot id: A0A076LCA6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1301915:JH146 RS02490
gene id: 1301915:JH146_RS02490
uniprot id: A0A076LIK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1301915:JH146 RS04650
gene id: 1301915:JH146_RS04650
uniprot id: A0A076LFW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1301915:JH146 RS03950
gene id: 1301915:JH146_RS03950
uniprot id: A0A076LFK5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS00855
gene id: 1301915:JH146_RS00855
uniprot id: A0A076LE24
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

1301915:JH146 RS02360
gene id: 1301915:JH146_RS02360
uniprot id: A0A076LIH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1301915:JH146 RS02720
gene id: 1301915:JH146_RS02720
uniprot id: A0A076LAI2
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

1301915:JH146 RS07090
gene id: 1301915:JH146_RS07090
uniprot id: A0A076LCI7
names: Similarity
messages: Belongs to the SUI1 family.

1301915:JH146 RS03485
gene id: 1301915:JH146_RS03485
uniprot id: A0A076LB31
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1301915:JH146 RS00370
gene id: 1301915:JH146_RS00370
uniprot id: A0A076L9C1
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS01580
gene id: 1301915:JH146_RS01580
uniprot id: A0A076LI18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1301915:JH146 RS07150
gene id: 1301915:JH146_RS07150
uniprot id: A0A076LH58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1301915:JH146 RS01275
gene id: 1301915:JH146_RS01275
uniprot id: A0A076L9V8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1301915:JH146 RS05835
gene id: 1301915:JH146_RS05835
uniprot id: A0A076LK68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1301915:JH146 RS03805
gene id: 1301915:JH146_RS03805
uniprot id: A0A076LFI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1301915:JH146 RS00385
gene id: 1301915:JH146_RS00385
uniprot id: A0A076LES0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1301915:JH146 RS04610
gene id: 1301915:JH146_RS04610
uniprot id: A0A076LJK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1301915:JH146 RS03400
gene id: 1301915:JH146_RS03400
uniprot id: A0A076LFC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1301915:JH146 RS05940
gene id: 1301915:JH146_RS05940
uniprot id: A0A076LCW6
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1301915:JH146 RS01335
gene id: 1301915:JH146_RS01335
uniprot id: A0A076LE94
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1301915:JH146 RS05205
gene id: 1301915:JH146_RS05205
uniprot id: A0A076LCF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1301915:JH146 RS04605
gene id: 1301915:JH146_RS04605
uniprot id: A0A076LH17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS02765
gene id: 1301915:JH146_RS02765
uniprot id: A0A076LFY8
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

1301915:JH146 RS02265
gene id: 1301915:JH146_RS02265
uniprot id: A0A076LAT2
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1301915:JH146 RS07105
gene id: 1301915:JH146_RS07105
uniprot id: A0A076LI98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1301915:JH146 RS06545
gene id: 1301915:JH146_RS06545
uniprot id: A0A076LKJ4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

1301915:JH146 RS06410
gene id: 1301915:JH146_RS06410
uniprot id: A0A076LD35
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1301915:JH146 RS04275
gene id: 1301915:JH146_RS04275
uniprot id: A0A076LBE3
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1301915:JH146 RS00740
gene id: 1301915:JH146_RS00740
uniprot id: A0A076L9L6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1301915:JH146 RS07400
gene id: 1301915:JH146_RS07400
uniprot id: A0A076LIH2
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1301915:JH146 RS04025
gene id: 1301915:JH146_RS04025
uniprot id: A0A076LGQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1301915:JH146 RS03385
gene id: 1301915:JH146_RS03385
uniprot id: A0A076LJ11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

1301915:JH146 RS05495
gene id: 1301915:JH146_RS05495
uniprot id: A0A076LGA7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS04820
gene id: 1301915:JH146_RS04820
uniprot id: A0A076LC88
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1301915:JH146 RS05690
gene id: 1301915:JH146_RS05690
uniprot id: A0A076LCN6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1301915:JH146 RS04875
gene id: 1301915:JH146_RS04875
uniprot id: A0A076LFZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1301915:JH146 RS07095
gene id: 1301915:JH146_RS07095
uniprot id: A0A076LDC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1301915:JH146 RS04050
gene id: 1301915:JH146_RS04050
uniprot id: A0A076LFL8
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1301915:JH146 RS05340
gene id: 1301915:JH146_RS05340
uniprot id: A0A076LHF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS07820
gene id: 1301915:JH146_RS07820
uniprot id: A0A076LCX4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1301915:JH146 RS06755
gene id: 1301915:JH146_RS06755
uniprot id: A0A076LD84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1301915:JH146 RS00205
gene id: 1301915:JH146_RS00205
uniprot id: A0A076LDL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1301915:JH146 RS04565
gene id: 1301915:JH146_RS04565
uniprot id: A0A076LBH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS06870
gene id: 1301915:JH146_RS06870
uniprot id: A0A076LKM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1301915:JH146 RS07595
gene id: 1301915:JH146_RS07595
uniprot id: A0A076LCT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1301915:JH146 RS00165
gene id: 1301915:JH146_RS00165
uniprot id: A0A076LH73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1301915:JH146 RS03030
gene id: 1301915:JH146_RS03030
uniprot id: A0A076LIV0
names: Similarity
messages: Belongs to the UPF0045 family.

1301915:JH146 RS00965
gene id: 1301915:JH146_RS00965
uniprot id: A0A076LHP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1301915:JH146 RS04265
gene id: 1301915:JH146_RS04265
uniprot id: A0A076LGU8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1301915:JH146 RS08225
gene id: 1301915:JH146_RS08225
uniprot id: A0A076LHM4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1301915:JH146 RS01495
gene id: 1301915:JH146_RS01495
uniprot id: A0A076LFC2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1301915:JH146 RS00690
gene id: 1301915:JH146_RS00690
uniprot id: A0A076L9K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

1301915:JH146 RS04175
gene id: 1301915:JH146_RS04175
uniprot id: A0A076LBD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS03405
gene id: 1301915:JH146_RS03405
uniprot id: A0A076LGF6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1301915:JH146 RS08145
gene id: 1301915:JH146_RS08145
uniprot id: A0A076LDX4
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1301915:JH146 RS01405
gene id: 1301915:JH146_RS01405
uniprot id: A0A076L9X0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

1301915:JH146 RS02145
gene id: 1301915:JH146_RS02145
uniprot id: A0A076LFN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1301915:JH146 RS06215
gene id: 1301915:JH146_RS06215
uniprot id: A0A076LGT9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1301915:JH146 RS00115
gene id: 1301915:JH146_RS00115
uniprot id: A0A076LH64
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1301915:JH146 RS01520
gene id: 1301915:JH146_RS01520
uniprot id: A0A076LFC6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1301915:JH146 RS05360
gene id: 1301915:JH146_RS05360
uniprot id: A0A076LG81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS06475
gene id: 1301915:JH146_RS06475
uniprot id: A0A076LD46
names: Similarity
messages: Belongs to the MCM family.

1301915:JH146 RS03055
gene id: 1301915:JH146_RS03055
uniprot id: A0A076LIV4
names: Similarity
messages: Belongs to the UPF0147 family.

1301915:JH146 RS04580
gene id: 1301915:JH146_RS04580
uniprot id: A0A076LH13
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

1301915:JH146 RS04925
gene id: 1301915:JH146_RS04925
uniprot id: A0A076LG03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1301915:JH146 RS05030
gene id: 1301915:JH146_RS05030
uniprot id: A0A076LG20
names: Similarity
messages: Belongs to the TrpC family.

1301915:JH146 RS02400
gene id: 1301915:JH146_RS02400
uniprot id: A0A076LES1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1301915:JH146 RS02335
gene id: 1301915:JH146_RS02335
uniprot id: A0A076LIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1301915:JH146 RS00150
gene id: 1301915:JH146_RS00150
uniprot id: A0A076L9I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1301915:JH146 RS02045
gene id: 1301915:JH146_RS02045
uniprot id: A0A076LA61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1301915:JH146 RS07845
gene id: 1301915:JH146_RS07845
uniprot id: A0A076LL33
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1301915:JH146 RS03955
gene id: 1301915:JH146_RS03955
uniprot id: A0A076LGP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1301915:JH146 RS04510
gene id: 1301915:JH146_RS04510
uniprot id: A0A076LJJ0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1301915:JH146 RS05565
gene id: 1301915:JH146_RS05565
uniprot id: A0A076LCK5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1301915:JH146 RS06135
gene id: 1301915:JH146_RS06135
uniprot id: A0A076LGS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1301915:JH146 RS02420
gene id: 1301915:JH146_RS02420
uniprot id: A0A076LAW5
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1301915:JH146 RS05405
gene id: 1301915:JH146_RS05405
uniprot id: A0A076LCH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1301915:JH146 RS04550
gene id: 1301915:JH146_RS04550
uniprot id: A0A076LFU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS04815
gene id: 1301915:JH146_RS04815
uniprot id: A0A076LBL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1301915:JH146 RS00425
gene id: 1301915:JH146_RS00425
uniprot id: A0A076L9P9
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

1301915:JH146 RS07250
gene id: 1301915:JH146_RS07250
uniprot id: A0A076LDE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1301915:JH146 RS06145
gene id: 1301915:JH146_RS06145
uniprot id: A0A076LKF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1301915:JH146 RS04600
gene id: 1301915:JH146_RS04600
uniprot id: A0A076LFV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS03865
gene id: 1301915:JH146_RS03865
uniprot id: A0A076LFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1301915:JH146 RS00975
gene id: 1301915:JH146_RS00975
uniprot id: A0A076LA58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS04645
gene id: 1301915:JH146_RS04645
uniprot id: A0A076LC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS07255
gene id: 1301915:JH146_RS07255
uniprot id: A0A076LH71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1301915:JH146 RS02485
gene id: 1301915:JH146_RS02485
uniprot id: A0A076LFU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1301915:JH146 RS08180
gene id: 1301915:JH146_RS08180
uniprot id: A0A076LIT4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1301915:JH146 RS07320
gene id: 1301915:JH146_RS07320
uniprot id: A0A076LH86
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1301915:JH146 RS03000
gene id: 1301915:JH146_RS03000
uniprot id: A0A076LG31
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS03185
gene id: 1301915:JH146_RS03185
uniprot id: A0A076LBC8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1301915:JH146 RS07970
gene id: 1301915:JH146_RS07970
uniprot id: A0A076LL56
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1301915:JH146 RS04685
gene id: 1301915:JH146_RS04685
uniprot id: A0A076LH42
names: Similarity
names: Subunit
messages: Belongs to the L-cysteine desulfidase family.
messages: Homotrimer.

1301915:JH146 RS02470
gene id: 1301915:JH146_RS02470
uniprot id: A0A076LAE1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1301915:JH146 RS07125
gene id: 1301915:JH146_RS07125
uniprot id: A0A076LH55
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1301915:JH146 RS02010
gene id: 1301915:JH146_RS02010
uniprot id: A0A076LFL5
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1301915:JH146 RS01900
gene id: 1301915:JH146_RS01900
uniprot id: A0A076LAK7
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS07030
gene id: 1301915:JH146_RS07030
uniprot id: A0A076LI83
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1301915:JH146 RS05480
gene id: 1301915:JH146_RS05480
uniprot id: A0A076LK10
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1301915:JH146 RS01280
gene id: 1301915:JH146_RS01280
uniprot id: A0A076LAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1301915:JH146 RS00935
gene id: 1301915:JH146_RS00935
uniprot id: A0A076LHP4
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

1301915:JH146 RS05335
gene id: 1301915:JH146_RS05335
uniprot id: A0A076LG75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS08385
gene id: 1301915:JH146_RS08385
uniprot id: A0A076LHR0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1301915:JH146 RS07145
gene id: 1301915:JH146_RS07145
uniprot id: A0A076LDD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1301915:JH146 RS01790
gene id: 1301915:JH146_RS01790
uniprot id: A0A076LA29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1301915:JH146 RS01570
gene id: 1301915:JH146_RS01570
uniprot id: A0A076LED7
names: Similarity
messages: Belongs to the UPF0248 family.

1301915:JH146 RS04490
gene id: 1301915:JH146_RS04490
uniprot id: A0A076LC42
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS03845
gene id: 1301915:JH146_RS03845
uniprot id: A0A076LJ84
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1301915:JH146 RS08350
gene id: 1301915:JH146_RS08350
uniprot id: A0A076LD71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1301915:JH146 RS07840
gene id: 1301915:JH146_RS07840
uniprot id: A0A076LIM8
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

1301915:JH146 RS00050
gene id: 1301915:JH146_RS00050
uniprot id: A0A076L9G3
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS03670
gene id: 1301915:JH146_RS03670
uniprot id: A0A076LBP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1301915:JH146 RS07705
gene id: 1301915:JH146_RS07705
uniprot id: A0A076LHE2
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

1301915:JH146 RS00525
gene id: 1301915:JH146_RS00525
uniprot id: A0A076L9S6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1301915:JH146 RS03100
gene id: 1301915:JH146_RS03100
uniprot id: A0A076LF50
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

1301915:JH146 RS00200
gene id: 1301915:JH146_RS00200
uniprot id: A0A076L9K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1301915:JH146 RS04280
gene id: 1301915:JH146_RS04280
uniprot id: A0A076LC04
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1301915:JH146 RS02785
gene id: 1301915:JH146_RS02785
uniprot id: A0A076LEZ2
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

1301915:JH146 RS00955
gene id: 1301915:JH146_RS00955
uniprot id: A0A076LE35
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1301915:JH146 RS01110
gene id: 1301915:JH146_RS01110
uniprot id: A0A076LE61
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

1301915:JH146 RS08325
gene id: 1301915:JH146_RS08325
uniprot id: A0A076LD66
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1301915:JH146 RS00715
gene id: 1301915:JH146_RS00715
uniprot id: A0A076L9L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1301915:JH146 RS04170
gene id: 1301915:JH146_RS04170
uniprot id: A0A076LJC5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1301915:JH146 RS04315
gene id: 1301915:JH146_RS04315
uniprot id: A0A076LGV8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1301915:JH146 RS03145
gene id: 1301915:JH146_RS03145
uniprot id: A0A076LBA5
names: Similarity
messages: Belongs to the UPF0216 family.

1301915:JH146 RS06485
gene id: 1301915:JH146_RS06485
uniprot id: A0A076LI00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1301915:JH146 RS08190
gene id: 1301915:JH146_RS08190
uniprot id: A0A076LD41
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1301915:JH146 RS02895
gene id: 1301915:JH146_RS02895
uniprot id: A0A076LIT1
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS01165
gene id: 1301915:JH146_RS01165
uniprot id: A0A076LF90
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1301915:JH146 RS06915
gene id: 1301915:JH146_RS06915
uniprot id: A0A076LH28
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS00285
gene id: 1301915:JH146_RS00285
uniprot id: A0A076LEQ4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS08290
gene id: 1301915:JH146_RS08290
uniprot id: A0A076LLA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS03255
gene id: 1301915:JH146_RS03255
uniprot id: A0A076LG82
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1301915:JH146 RS04115
gene id: 1301915:JH146_RS04115
uniprot id: A0A076LJB8
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1301915:JH146 RS02075
gene id: 1301915:JH146_RS02075
uniprot id: A0A076LAP3
names: Similarity
messages: Belongs to the UPF0285 family.

1301915:JH146 RS05365
gene id: 1301915:JH146_RS05365
uniprot id: A0A076LHF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS06300
gene id: 1301915:JH146_RS06300
uniprot id: A0A076LKG6
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

1301915:JH146 RS00360
gene id: 1301915:JH146_RS00360
uniprot id: A0A076LER5
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

1301915:JH146 RS05290
gene id: 1301915:JH146_RS05290
uniprot id: A0A076LHE3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1301915:JH146 RS02545
gene id: 1301915:JH146_RS02545
uniprot id: A0A076LAF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1301915:JH146 RS02960
gene id: 1301915:JH146_RS02960
uniprot id: A0A076LB64
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1301915:JH146 RS05700
gene id: 1301915:JH146_RS05700
uniprot id: A0A076LHL4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1301915:JH146 RS08230
gene id: 1301915:JH146_RS08230
uniprot id: A0A076LIU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1301915:JH146 RS00925
gene id: 1301915:JH146_RS00925
uniprot id: A0A076LE34
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1301915:JH146 RS02345
gene id: 1301915:JH146_RS02345
uniprot id: A0A076LAU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1301915:JH146 RS05725
gene id: 1301915:JH146_RS05725
uniprot id: A0A076LHL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

1301915:JH146 RS02855
gene id: 1301915:JH146_RS02855
uniprot id: A0A076LB44
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

1301915:JH146 RS00875
gene id: 1301915:JH146_RS00875
uniprot id: A0A076LE27
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1301915:JH146 RS02285
gene id: 1301915:JH146_RS02285
uniprot id: A0A076LIF7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS03870
gene id: 1301915:JH146_RS03870
uniprot id: A0A076LGN2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1301915:JH146 RS04840
gene id: 1301915:JH146_RS04840
uniprot id: A0A076LBL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1301915:JH146 RS04555
gene id: 1301915:JH146_RS04555
uniprot id: A0A076LH09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1301915:JH146 RS04595
gene id: 1301915:JH146_RS04595
uniprot id: A0A076LC56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS05040
gene id: 1301915:JH146_RS05040
uniprot id: A0A076LHA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS08030
gene id: 1301915:JH146_RS08030
uniprot id: A0A076LDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1301915:JH146 RS04335
gene id: 1301915:JH146_RS04335
uniprot id: A0A076LFR0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

1301915:JH146 RS06890
gene id: 1301915:JH146_RS06890
uniprot id: A0A076LI62
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS04235
gene id: 1301915:JH146_RS04235
uniprot id: A0A076LFP3
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS03560
gene id: 1301915:JH146_RS03560
uniprot id: A0A076LJ40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1301915:JH146 RS07635
gene id: 1301915:JH146_RS07635
uniprot id: A0A076LIL0
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

1301915:JH146 RS06655
gene id: 1301915:JH146_RS06655
uniprot id: A0A076LI25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS02405
gene id: 1301915:JH146_RS02405
uniprot id: A0A076LFT0
names: Similarity
messages: Belongs to the UPF0254 family.

1301915:JH146 RS05325
gene id: 1301915:JH146_RS05325
uniprot id: A0A076LBV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS02080
gene id: 1301915:JH146_RS02080
uniprot id: A0A076LEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1301915:JH146 RS02565
gene id: 1301915:JH146_RS02565
uniprot id: A0A076LIL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1301915:JH146 RS04585
gene id: 1301915:JH146_RS04585
uniprot id: A0A076LJK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1301915:JH146 RS06885
gene id: 1301915:JH146_RS06885
uniprot id: A0A076LH24
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

1301915:JH146 RS00710
gene id: 1301915:JH146_RS00710
uniprot id: A0A076LHI5
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

1301915:JH146 RS02300
gene id: 1301915:JH146_RS02300
uniprot id: A0A076LEQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

1301915:JH146 RS05065
gene id: 1301915:JH146_RS05065
uniprot id: A0A076LHB0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS08300
gene id: 1301915:JH146_RS08300
uniprot id: A0A076LE03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1301915:JH146 RS05990
gene id: 1301915:JH146_RS05990
uniprot id: A0A076LCX8
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1301915:JH146 RS07405
gene id: 1301915:JH146_RS07405
uniprot id: A0A076LKU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1301915:JH146 RS03095
gene id: 1301915:JH146_RS03095
uniprot id: A0A076LB92
names: Subunit
messages: Homotetramer.

1301915:JH146 RS02070
gene id: 1301915:JH146_RS02070
uniprot id: A0A076LA65
names: Similarity
messages: Belongs to the MtxX family.

1301915:JH146 RS00005
gene id: 1301915:JH146_RS00005
uniprot id: A0A076LDG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

1301915:JH146 RS03895
gene id: 1301915:JH146_RS03895
uniprot id: A0A076LGN5
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS04400
gene id: 1301915:JH146_RS04400
uniprot id: A0A076LJG9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1301915:JH146 RS06960
gene id: 1301915:JH146_RS06960
uniprot id: A0A076LCG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS07975
gene id: 1301915:JH146_RS07975
uniprot id: A0A076LD04
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

1301915:JH146 RS06975
gene id: 1301915:JH146_RS06975
uniprot id: A0A076LI73
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1301915:JH146 RS02245
gene id: 1301915:JH146_RS02245
uniprot id: A0A076LEQ1
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

1301915:JH146 RS06945
gene id: 1301915:JH146_RS06945
uniprot id: A0A076LH32
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1301915:JH146 RS04035
gene id: 1301915:JH146_RS04035
uniprot id: A0A076LJA6
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

1301915:JH146 RS02755
gene id: 1301915:JH146_RS02755
uniprot id: A0A076LEY9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1301915:JH146 RS02370
gene id: 1301915:JH146_RS02370
uniprot id: A0A076LAV2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS04215
gene id: 1301915:JH146_RS04215
uniprot id: A0A076LGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1301915:JH146 RS01455
gene id: 1301915:JH146_RS01455
uniprot id: A0A076L9X6
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1301915:JH146 RS00960
gene id: 1301915:JH146_RS00960
uniprot id: A0A076LF63
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1301915:JH146 RS08280
gene id: 1301915:JH146_RS08280
uniprot id: A0A076LHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1301915:JH146 RS07995
gene id: 1301915:JH146_RS07995
uniprot id: A0A076LL61
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1301915:JH146 RS00430
gene id: 1301915:JH146_RS00430
uniprot id: A0A076LDR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1301915:JH146 RS02050
gene id: 1301915:JH146_RS02050
uniprot id: A0A076LAN8
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS06370
gene id: 1301915:JH146_RS06370
uniprot id: A0A076LHY5
names: Similarity
messages: Belongs to the thymidylate kinase family.

1301915:JH146 RS01205
gene id: 1301915:JH146_RS01205
uniprot id: A0A076LA96
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS07370
gene id: 1301915:JH146_RS07370
uniprot id: A0A076LH95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1301915:JH146 RS01600
gene id: 1301915:JH146_RS01600
uniprot id: A0A076LFD8
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS01480
gene id: 1301915:JH146_RS01480
uniprot id: A0A076L9Y0
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1301915:JH146 RS01190
gene id: 1301915:JH146_RS01190
uniprot id: A0A076LF93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

1301915:JH146 RS05370
gene id: 1301915:JH146_RS05370
uniprot id: A0A076LJZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1301915:JH146 RS04975
gene id: 1301915:JH146_RS04975
uniprot id: A0A076LCB0
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1301915:JH146 RS08285
gene id: 1301915:JH146_RS08285
uniprot id: A0A076LIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1301915:JH146 RS00155
gene id: 1301915:JH146_RS00155
uniprot id: A0A076LDK3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

1301915:JH146 RS03230
gene id: 1301915:JH146_RS03230
uniprot id: A0A076LG78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1301915:JH146 RS01990
gene id: 1301915:JH146_RS01990
uniprot id: A0A076LI97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1301915:JH146 RS07610
gene id: 1301915:JH146_RS07610
uniprot id: A0A076LIK9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1301915:JH146 RS07815
gene id: 1301915:JH146_RS07815
uniprot id: A0A076LL28
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS06700
gene id: 1301915:JH146_RS06700
uniprot id: A0A076LGZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1301915:JH146 RS00870
gene id: 1301915:JH146_RS00870
uniprot id: A0A076LA41
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1301915:JH146 RS03755
gene id: 1301915:JH146_RS03755
uniprot id: A0A076LFI1
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS01030
gene id: 1301915:JH146_RS01030
uniprot id: A0A076LE46
names: Similarity
messages: Belongs to the ZPR1 family.

1301915:JH146 RS00895
gene id: 1301915:JH146_RS00895
uniprot id: A0A076LA44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

1301915:JH146 RS05190
gene id: 1301915:JH146_RS05190
uniprot id: A0A076LHC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

1301915:JH146 RS03645
gene id: 1301915:JH146_RS03645
uniprot id: A0A076LB51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

1301915:JH146 RS05090
gene id: 1301915:JH146_RS05090
uniprot id: A0A076LHB3
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

1301915:JH146 RS04395
gene id: 1301915:JH146_RS04395
uniprot id: A0A076LGX7
names: Similarity
messages: Belongs to the CutA family.

1301915:JH146 RS04615
gene id: 1301915:JH146_RS04615
uniprot id: A0A076LBI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1301915:JH146 RS05245
gene id: 1301915:JH146_RS05245
uniprot id: A0A076LJX2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1301915:JH146 RS00490
gene id: 1301915:JH146_RS00490
uniprot id: A0A076LHE5
names: Similarity
messages: Belongs to the archaeal ATPase family.

1301915:JH146 RS02220
gene id: 1301915:JH146_RS02220
uniprot id: A0A076LEP8
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

1301915:JH146 RS07480
gene id: 1301915:JH146_RS07480
uniprot id: A0A076LHB2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1301915:JH146 RS01830
gene id: 1301915:JH146_RS01830
uniprot id: A0A076LFI4
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

1301915:JH146 RS08335
gene id: 1301915:JH146_RS08335
uniprot id: A0A076LHP7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1301915:JH146 RS03735
gene id: 1301915:JH146_RS03735
uniprot id: A0A076LGL7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1301915:JH146 RS03745
gene id: 1301915:JH146_RS03745
uniprot id: A0A076LB66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1301915:JH146 RS07385
gene id: 1301915:JH146_RS07385
uniprot id: A0A076LCN4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1301915:JH146 RS04525
gene id: 1301915:JH146_RS04525
uniprot id: A0A076LFU1
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1301915:JH146 RS07470
gene id: 1301915:JH146_RS07470
uniprot id: A0A076LCR4
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1301915:JH146 RS05080
gene id: 1301915:JH146_RS05080
uniprot id: A0A076LCC9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1301915:JH146 RS05350
gene id: 1301915:JH146_RS05350
uniprot id: A0A076LBV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1301915:JH146 RS00735
gene id: 1301915:JH146_RS00735
uniprot id: A0A076LHJ1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

1301915:JH146 RS04330
gene id: 1301915:JH146_RS04330
uniprot id: A0A076LC14
names: Similarity
messages: Belongs to the UPF0111 family.

1301915:JH146 RS00780
gene id: 1301915:JH146_RS00780
uniprot id: A0A076LE10
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1301915:JH146 RS06895
gene id: 1301915:JH146_RS06895
uniprot id: A0A076LKM7
names: Similarity
messages: Belongs to the acylphosphatase family.

1301915:JH146 RS04245
gene id: 1301915:JH146_RS04245
uniprot id: A0A076LJD7
names: Subcellular Location Annotation
messages: Membrane

1301915:JH146 RS08195
gene id: 1301915:JH146_RS08195
uniprot id: A0A076LDY6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.