1298593:TOL RS16785
gene id: 1298593:TOL_RS16785
uniprot id: M5E929
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
messages: Protects the bacterial cell from host peptidases.

1298593:TOL RS04280
gene id: 1298593:TOL_RS04280
uniprot id: M5DPG7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS07220
gene id: 1298593:TOL_RS07220
uniprot id: M5DRY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1298593:TOL RS11140
gene id: 1298593:TOL_RS11140
uniprot id: M5DS08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS04270
gene id: 1298593:TOL_RS04270
uniprot id: M5DPA2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

1298593:TOL RS08515
gene id: 1298593:TOL_RS08515
uniprot id: M5DRY1
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

1298593:TOL RS15890
gene id: 1298593:TOL_RS15890
uniprot id: M5DUX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS01690
gene id: 1298593:TOL_RS01690
uniprot id: M5DNQ7
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

1298593:TOL RS04895
gene id: 1298593:TOL_RS04895
uniprot id: M5DNC7
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS07335
gene id: 1298593:TOL_RS07335
uniprot id: M5DR23
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1298593:TOL RS16705
gene id: 1298593:TOL_RS16705
uniprot id: M5DWY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1298593:TOL RS03045
gene id: 1298593:TOL_RS03045
uniprot id: M5DNR8
names: Similarity
messages: Belongs to the alkaline phosphatase family.

1298593:TOL RS13110
gene id: 1298593:TOL_RS13110
uniprot id: M5DUB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1298593:TOL RS16915
gene id: 1298593:TOL_RS16915
uniprot id: M5DVI5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1298593:TOL RS00175
gene id: 1298593:TOL_RS00175
uniprot id: M5DY89
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

1298593:TOL RS11600
gene id: 1298593:TOL_RS11600
uniprot id: M5DS91
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS12075
gene id: 1298593:TOL_RS12075
uniprot id: M5DTP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1298593:TOL RS07460
gene id: 1298593:TOL_RS07460
uniprot id: M5DPX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1298593:TOL RS01020
gene id: 1298593:TOL_RS01020
uniprot id: M5DMP2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS07200
gene id: 1298593:TOL_RS07200
uniprot id: M5DQY9
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1298593:TOL RS14930
gene id: 1298593:TOL_RS14930
uniprot id: M5DUE0
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS07100
gene id: 1298593:TOL_RS07100
uniprot id: M5DRW0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

1298593:TOL RS15120
gene id: 1298593:TOL_RS15120
uniprot id: M5E850
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1298593:TOL RS00460
gene id: 1298593:TOL_RS00460
uniprot id: M5DMG3
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS08935
gene id: 1298593:TOL_RS08935
uniprot id: M5DS55
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1298593:TOL RS00650
gene id: 1298593:TOL_RS00650
uniprot id: M5DMI7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

1298593:TOL RS01935
gene id: 1298593:TOL_RS01935
uniprot id: M5DN55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1298593:TOL RS01460
gene id: 1298593:TOL_RS01460
uniprot id: M5DYZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

1298593:TOL RS12030
gene id: 1298593:TOL_RS12030
uniprot id: M5E5Z2
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

1298593:TOL RS03745
gene id: 1298593:TOL_RS03745
uniprot id: M5E0D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1298593:TOL RS13130
gene id: 1298593:TOL_RS13130
uniprot id: M5DUP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1298593:TOL RS13095
gene id: 1298593:TOL_RS13095
uniprot id: M5DT90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1298593:TOL RS12870
gene id: 1298593:TOL_RS12870
uniprot id: M5E6H7
names: Similarity
messages: Belongs to the GST superfamily.

1298593:TOL RS00560
gene id: 1298593:TOL_RS00560
uniprot id: M5DYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

1298593:TOL RS10670
gene id: 1298593:TOL_RS10670
uniprot id: M5E572
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1298593:TOL RS16155
gene id: 1298593:TOL_RS16155
uniprot id: M5DVX8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1298593:TOL RS11750
gene id: 1298593:TOL_RS11750
uniprot id: M5DTT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1298593:TOL RS15520
gene id: 1298593:TOL_RS15520
uniprot id: M5DWG6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1298593:TOL RS01465
gene id: 1298593:TOL_RS01465
uniprot id: M5DLR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

1298593:TOL RS00350
gene id: 1298593:TOL_RS00350
uniprot id: M5DMH1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS02885
gene id: 1298593:TOL_RS02885
uniprot id: M5DNM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GlpE family.
messages: Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
messages: Cytoplasm

1298593:TOL RS13230
gene id: 1298593:TOL_RS13230
uniprot id: M5DV65
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1298593:TOL RS08025
gene id: 1298593:TOL_RS08025
uniprot id: M5DQA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1298593:TOL RS09520
gene id: 1298593:TOL_RS09520
uniprot id: M5DR30
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS15100
gene id: 1298593:TOL_RS15100
uniprot id: M5DUH6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1298593:TOL RS07180
gene id: 1298593:TOL_RS07180
uniprot id: M5E2X4
names: Similarity
messages: Belongs to the citrate synthase family.

1298593:TOL RS06250
gene id: 1298593:TOL_RS06250
uniprot id: M5DP47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

1298593:TOL RS03880
gene id: 1298593:TOL_RS03880
uniprot id: M5DP35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1298593:TOL RS03935
gene id: 1298593:TOL_RS03935
uniprot id: M5E0J6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1298593:TOL RS13925
gene id: 1298593:TOL_RS13925
uniprot id: M5DUQ3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1298593:TOL RS00805
gene id: 1298593:TOL_RS00805
uniprot id: M5DLG8
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS17010
gene id: 1298593:TOL_RS17010
uniprot id: M5DVL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1298593:TOL RS12510
gene id: 1298593:TOL_RS12510
uniprot id: M5DUB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1298593:TOL RS13245
gene id: 1298593:TOL_RS13245
uniprot id: M5DTB5
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

1298593:TOL RS01450
gene id: 1298593:TOL_RS01450
uniprot id: M5DNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1298593:TOL RS10005
gene id: 1298593:TOL_RS10005
uniprot id: M5DRE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1298593:TOL RS01945
gene id: 1298593:TOL_RS01945
uniprot id: M5DN30
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1298593:TOL RS01920
gene id: 1298593:TOL_RS01920
uniprot id: M5DN25
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1298593:TOL RS04030
gene id: 1298593:TOL_RS04030
uniprot id: M5DP61
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1298593:TOL RS17740
gene id: 1298593:TOL_RS17740
uniprot id: M5DXA8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1298593:TOL RS10240
gene id: 1298593:TOL_RS10240
uniprot id: M5DTL1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1298593:TOL RS07345
gene id: 1298593:TOL_RS07345
uniprot id: M5DPU5
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1298593:TOL RS15225
gene id: 1298593:TOL_RS15225
uniprot id: M5DVX7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS04605
gene id: 1298593:TOL_RS04605
uniprot id: M5DPQ0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1298593:TOL RS08320
gene id: 1298593:TOL_RS08320
uniprot id: M5DRL3
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1298593:TOL RS14840
gene id: 1298593:TOL_RS14840
uniprot id: M5DVN3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1298593:TOL RS01630
gene id: 1298593:TOL_RS01630
uniprot id: M5DZ25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1298593:TOL RS12590
gene id: 1298593:TOL_RS12590
uniprot id: M5DUD7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS10365
gene id: 1298593:TOL_RS10365
uniprot id: M5DRN3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS03975
gene id: 1298593:TOL_RS03975
uniprot id: M5DQ11
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1298593:TOL RS01015
gene id: 1298593:TOL_RS01015
uniprot id: M5DNE7
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1298593:TOL RS12755
gene id: 1298593:TOL_RS12755
uniprot id: M5DUI4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: In the C-terminal section; belongs to the transglycosylase Slt family.
messages: In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
messages: The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.

1298593:TOL RS03025
gene id: 1298593:TOL_RS03025
uniprot id: M5DPL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

1298593:TOL RS06800
gene id: 1298593:TOL_RS06800
uniprot id: M5DPG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS17425
gene id: 1298593:TOL_RS17425
uniprot id: M5DX14
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1298593:TOL RS05680
gene id: 1298593:TOL_RS05680
uniprot id: M5DQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS08990
gene id: 1298593:TOL_RS08990
uniprot id: M5E445
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1298593:TOL RS04845
gene id: 1298593:TOL_RS04845
uniprot id: M5DNB8
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS12070
gene id: 1298593:TOL_RS12070
uniprot id: M5DUH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1298593:TOL RS14900
gene id: 1298593:TOL_RS14900
uniprot id: M5E7Y8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS15180
gene id: 1298593:TOL_RS15180
uniprot id: M5DWB7
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1298593:TOL RS06345
gene id: 1298593:TOL_RS06345
uniprot id: M5DQE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1298593:TOL RS08085
gene id: 1298593:TOL_RS08085
uniprot id: M5DRI2
names: Similarity
messages: Belongs to the FrmR/RcnR family.

1298593:TOL RS13240
gene id: 1298593:TOL_RS13240
uniprot id: M5E6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1298593:TOL RS00765
gene id: 1298593:TOL_RS00765
uniprot id: M5DMP3
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

1298593:TOL RS17085
gene id: 1298593:TOL_RS17085
uniprot id: M5DVN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS17105
gene id: 1298593:TOL_RS17105
uniprot id: M5E9E2
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.

1298593:TOL RS17035
gene id: 1298593:TOL_RS17035
uniprot id: M5DVM1
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1298593:TOL RS10875
gene id: 1298593:TOL_RS10875
uniprot id: M5DT11
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1298593:TOL RS15650
gene id: 1298593:TOL_RS15650
uniprot id: M5DVR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

1298593:TOL RS00080
gene id: 1298593:TOL_RS00080
uniprot id: M5DL35
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS16540
gene id: 1298593:TOL_RS16540
uniprot id: M5DW52
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1298593:TOL RS06750
gene id: 1298593:TOL_RS06750
uniprot id: M5DPF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1298593:TOL RS17755
gene id: 1298593:TOL_RS17755
uniprot id: M5E9Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

1298593:TOL RS01595
gene id: 1298593:TOL_RS01595
uniprot id: M5DN09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

1298593:TOL RS13155
gene id: 1298593:TOL_RS13155
uniprot id: M5DUP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1298593:TOL RS05505
gene id: 1298593:TOL_RS05505
uniprot id: M5E1Y7
names: Similarity
messages: Belongs to the peptidase M1 family.

1298593:TOL RS10025
gene id: 1298593:TOL_RS10025
uniprot id: M5E4U6
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS12750
gene id: 1298593:TOL_RS12750
uniprot id: M5DT33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

1298593:TOL RS01290
gene id: 1298593:TOL_RS01290
uniprot id: M5DLN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1298593:TOL RS13890
gene id: 1298593:TOL_RS13890
uniprot id: M5DV32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1298593:TOL RS10345
gene id: 1298593:TOL_RS10345
uniprot id: M5DT26
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

1298593:TOL RS05210
gene id: 1298593:TOL_RS05210
uniprot id: M5DQV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

1298593:TOL RS00240
gene id: 1298593:TOL_RS00240
uniprot id: M5DMB7
names: Similarity
messages: Belongs to the peptidase S8 family.

1298593:TOL RS10355
gene id: 1298593:TOL_RS10355
uniprot id: M5DST8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1298593:TOL RS17020
gene id: 1298593:TOL_RS17020
uniprot id: M5DX35
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1298593:TOL RS14380
gene id: 1298593:TOL_RS14380
uniprot id: M5DTZ3
names: Similarity
messages: Belongs to the peptidase S41A family.

1298593:TOL RS15170
gene id: 1298593:TOL_RS15170
uniprot id: M5DUK4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1298593:TOL RS04735
gene id: 1298593:TOL_RS04735
uniprot id: M5DQI6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1298593:TOL RS06725
gene id: 1298593:TOL_RS06725
uniprot id: M5DPE6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1298593:TOL RS16535
gene id: 1298593:TOL_RS16535
uniprot id: M5DWV3
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1298593:TOL RS15550
gene id: 1298593:TOL_RS15550
uniprot id: M5DVP6
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS03005
gene id: 1298593:TOL_RS03005
uniprot id: M5DNP7
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1298593:TOL RS11740
gene id: 1298593:TOL_RS11740
uniprot id: M5E5T0
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1298593:TOL RS17220
gene id: 1298593:TOL_RS17220
uniprot id: M5DWK4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1298593:TOL RS01145
gene id: 1298593:TOL_RS01145
uniprot id: M5DYS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS14515
gene id: 1298593:TOL_RS14515
uniprot id: M5DVU2
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1298593:TOL RS08375
gene id: 1298593:TOL_RS08375
uniprot id: M5DQG3
names: Similarity
messages: Belongs to the ArsC family.

1298593:TOL RS12900
gene id: 1298593:TOL_RS12900
uniprot id: M5DT58
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS00565
gene id: 1298593:TOL_RS00565
uniprot id: M5DLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

1298593:TOL RS12920
gene id: 1298593:TOL_RS12920
uniprot id: M5E6I8
names: Function
names: Similarity
messages: Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
messages: Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia.

1298593:TOL RS10925
gene id: 1298593:TOL_RS10925
uniprot id: M5DTX1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1298593:TOL RS16910
gene id: 1298593:TOL_RS16910
uniprot id: M5E973
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1298593:TOL RS12445
gene id: 1298593:TOL_RS12445
uniprot id: M5DUA0
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS15735
gene id: 1298593:TOL_RS15735
uniprot id: M5E8F8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS15760
gene id: 1298593:TOL_RS15760
uniprot id: M5E8G3
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1298593:TOL RS02180
gene id: 1298593:TOL_RS02180
uniprot id: M5DM11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1298593:TOL RS03920
gene id: 1298593:TOL_RS03920
uniprot id: M5DP93
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1298593:TOL RS01265
gene id: 1298593:TOL_RS01265
uniprot id: M5DYV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1298593:TOL RS04485
gene id: 1298593:TOL_RS04485
uniprot id: M5E0Z4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1298593:TOL RS13105
gene id: 1298593:TOL_RS13105
uniprot id: M5DV48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1298593:TOL RS03870
gene id: 1298593:TOL_RS03870
uniprot id: M5DP82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1298593:TOL RS17490
gene id: 1298593:TOL_RS17490
uniprot id: M5DVZ3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1298593:TOL RS16570
gene id: 1298593:TOL_RS16570
uniprot id: M5DVA9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1298593:TOL RS07060
gene id: 1298593:TOL_RS07060
uniprot id: M5E2T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS04615
gene id: 1298593:TOL_RS04615
uniprot id: M5DPI1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS16455
gene id: 1298593:TOL_RS16455
uniprot id: M5E8T2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1298593:TOL RS00675
gene id: 1298593:TOL_RS00675
uniprot id: M5DYJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

1298593:TOL RS11935
gene id: 1298593:TOL_RS11935
uniprot id: M5DSH0
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

1298593:TOL RS08945
gene id: 1298593:TOL_RS08945
uniprot id: M5DRX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1298593:TOL RS16665
gene id: 1298593:TOL_RS16665
uniprot id: M5E8Y8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1298593:TOL RS18850
gene id: 1298593:TOL_RS18850
uniprot id: M5DWV7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1298593:TOL RS01970
gene id: 1298593:TOL_RS01970
uniprot id: M5DN35
names: Similarity
messages: Belongs to the elongation factor P family.

1298593:TOL RS08930
gene id: 1298593:TOL_RS08930
uniprot id: M5DQQ6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1298593:TOL RS08435
gene id: 1298593:TOL_RS08435
uniprot id: M5DQH1
names: Similarity
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.

1298593:TOL RS11050
gene id: 1298593:TOL_RS11050
uniprot id: M5DTZ4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1298593:TOL RS12315
gene id: 1298593:TOL_RS12315
uniprot id: M5E661
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1298593:TOL RS06075
gene id: 1298593:TOL_RS06075
uniprot id: M5DP08
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1298593:TOL RS16310
gene id: 1298593:TOL_RS16310
uniprot id: M5DV51
names: Similarity
messages: Belongs to the Fur family.

1298593:TOL RS09770
gene id: 1298593:TOL_RS09770
uniprot id: M5DSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1298593:TOL RS07435
gene id: 1298593:TOL_RS07435
uniprot id: M5DR44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

1298593:TOL RS11825
gene id: 1298593:TOL_RS11825
uniprot id: M5DTU5
names: Similarity
messages: Belongs to the DEAD box helicase family.

1298593:TOL RS04550
gene id: 1298593:TOL_RS04550
uniprot id: M5DN60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS04475
gene id: 1298593:TOL_RS04475
uniprot id: M5DQB1
names: Caution
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS07350
gene id: 1298593:TOL_RS07350
uniprot id: M5DR88
names: Similarity
messages: Belongs to the universal stress protein A family.

1298593:TOL RS08880
gene id: 1298593:TOL_RS08880
uniprot id: M5DS45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1298593:TOL RS03775
gene id: 1298593:TOL_RS03775
uniprot id: M5DMS8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1298593:TOL RS16580
gene id: 1298593:TOL_RS16580
uniprot id: M5DWW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1298593:TOL RS14405
gene id: 1298593:TOL_RS14405
uniprot id: M5DU00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1298593:TOL RS14175
gene id: 1298593:TOL_RS14175
uniprot id: M5DTU4
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

1298593:TOL RS06650
gene id: 1298593:TOL_RS06650
uniprot id: M5DPD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1298593:TOL RS10440
gene id: 1298593:TOL_RS10440
uniprot id: M5DRP6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS13905
gene id: 1298593:TOL_RS13905
uniprot id: M5E748
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS08445
gene id: 1298593:TOL_RS08445
uniprot id: M5DSL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

1298593:TOL RS08705
gene id: 1298593:TOL_RS08705
uniprot id: M5DQL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1298593:TOL RS13785
gene id: 1298593:TOL_RS13785
uniprot id: M5E723
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

1298593:TOL RS17565
gene id: 1298593:TOL_RS17565
uniprot id: M5E9T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1298593:TOL RS14505
gene id: 1298593:TOL_RS14505
uniprot id: M5DU26
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1298593:TOL RS00685
gene id: 1298593:TOL_RS00685
uniprot id: M5DMN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1298593:TOL RS01525
gene id: 1298593:TOL_RS01525
uniprot id: M5DNM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

1298593:TOL RS18310
gene id: 1298593:TOL_RS18310
uniprot id: M5DRN8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GSP I family.
messages: Cell inner membrane
messages: Cleaved by prepilin peptidase.
messages: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane
messages: Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus.

1298593:TOL RS04010
gene id: 1298593:TOL_RS04010
uniprot id: M5DMW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1298593:TOL RS03930
gene id: 1298593:TOL_RS03930
uniprot id: M5DP45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1298593:TOL RS16625
gene id: 1298593:TOL_RS16625
uniprot id: M5DWK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1298593:TOL RS02655
gene id: 1298593:TOL_RS02655
uniprot id: M5DPC6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1298593:TOL RS01605
gene id: 1298593:TOL_RS01605
uniprot id: M5DMX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

1298593:TOL RS06000
gene id: 1298593:TOL_RS06000
uniprot id: M5DNZ2
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS15720
gene id: 1298593:TOL_RS15720
uniprot id: M5DW41
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1298593:TOL RS14955
gene id: 1298593:TOL_RS14955
uniprot id: M5DUE5
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1298593:TOL RS14635
gene id: 1298593:TOL_RS14635
uniprot id: M5DVW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1298593:TOL RS00205
gene id: 1298593:TOL_RS00205
uniprot id: M5DL65
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS04035
gene id: 1298593:TOL_RS04035
uniprot id: M5E0M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.

1298593:TOL RS06615
gene id: 1298593:TOL_RS06615
uniprot id: M5DQL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1298593:TOL RS01510
gene id: 1298593:TOL_RS01510
uniprot id: M5DZ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1298593:TOL RS04610
gene id: 1298593:TOL_RS04610
uniprot id: M5DQF2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1298593:TOL RS09420
gene id: 1298593:TOL_RS09420
uniprot id: M5DT20
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
messages: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS09515
gene id: 1298593:TOL_RS09515
uniprot id: M5E4F5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

1298593:TOL RS09350
gene id: 1298593:TOL_RS09350
uniprot id: M5DSD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS03865
gene id: 1298593:TOL_RS03865
uniprot id: M5DMU3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS14035
gene id: 1298593:TOL_RS14035
uniprot id: M5DTR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1298593:TOL RS12595
gene id: 1298593:TOL_RS12595
uniprot id: M5DUU9
names: Similarity
messages: Belongs to the UPF0145 family.

1298593:TOL RS04515
gene id: 1298593:TOL_RS04515
uniprot id: M5DQC5
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

1298593:TOL RS08490
gene id: 1298593:TOL_RS08490
uniprot id: M5DRX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1298593:TOL RS07895
gene id: 1298593:TOL_RS07895
uniprot id: M5E3J5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

1298593:TOL RS16640
gene id: 1298593:TOL_RS16640
uniprot id: M5E8X9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1298593:TOL RS11040
gene id: 1298593:TOL_RS11040
uniprot id: M5DRZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS14970
gene id: 1298593:TOL_RS14970
uniprot id: M5DVD3
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

1298593:TOL RS00180
gene id: 1298593:TOL_RS00180
uniprot id: M5DL61
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1298593:TOL RS13935
gene id: 1298593:TOL_RS13935
uniprot id: M5DTP6
names: Similarity
messages: Belongs to the thioredoxin family.

1298593:TOL RS11280
gene id: 1298593:TOL_RS11280
uniprot id: M5DT93
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1298593:TOL RS03470
gene id: 1298593:TOL_RS03470
uniprot id: M5DNX3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS07130
gene id: 1298593:TOL_RS07130
uniprot id: M5DQX5
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS16795
gene id: 1298593:TOL_RS16795
uniprot id: M5DWN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS06005
gene id: 1298593:TOL_RS06005
uniprot id: M5DQI8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1298593:TOL RS11775
gene id: 1298593:TOL_RS11775
uniprot id: M5DTT4
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS02905
gene id: 1298593:TOL_RS02905
uniprot id: M5DPJ7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

1298593:TOL RS14045
gene id: 1298593:TOL_RS14045
uniprot id: M5DVJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

1298593:TOL RS11590
gene id: 1298593:TOL_RS11590
uniprot id: M5DTF2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1298593:TOL RS07370
gene id: 1298593:TOL_RS07370
uniprot id: M5DPV0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS15780
gene id: 1298593:TOL_RS15780
uniprot id: M5DVS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1298593:TOL RS01190
gene id: 1298593:TOL_RS01190
uniprot id: M5DYT6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1298593:TOL RS04885
gene id: 1298593:TOL_RS04885
uniprot id: M5DPN1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1298593:TOL RS11605
gene id: 1298593:TOL_RS11605
uniprot id: M5DTP9
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1298593:TOL RS14935
gene id: 1298593:TOL_RS14935
uniprot id: M5DVQ7
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1298593:TOL RS15775
gene id: 1298593:TOL_RS15775
uniprot id: M5DWJ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

1298593:TOL RS14520
gene id: 1298593:TOL_RS14520
uniprot id: M5DV24
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

1298593:TOL RS10790
gene id: 1298593:TOL_RS10790
uniprot id: M5DT99
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

1298593:TOL RS11625
gene id: 1298593:TOL_RS11625
uniprot id: M5DS96
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS10250
gene id: 1298593:TOL_RS10250
uniprot id: M5E523
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1298593:TOL RS15185
gene id: 1298593:TOL_RS15185
uniprot id: M5DVJ5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1298593:TOL RS08450
gene id: 1298593:TOL_RS08450
uniprot id: M5DRN5
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1298593:TOL RS06780
gene id: 1298593:TOL_RS06780
uniprot id: M5DQW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS16595
gene id: 1298593:TOL_RS16595
uniprot id: M5DVB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1298593:TOL RS07515
gene id: 1298593:TOL_RS07515
uniprot id: M5DRC8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1298593:TOL RS02135
gene id: 1298593:TOL_RS02135
uniprot id: M5DN78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1298593:TOL RS16325
gene id: 1298593:TOL_RS16325
uniprot id: M5DW13
names: Similarity
messages: Belongs to the SCO1/2 family.

1298593:TOL RS15205
gene id: 1298593:TOL_RS15205
uniprot id: M5DWC0
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1298593:TOL RS04245
gene id: 1298593:TOL_RS04245
uniprot id: M5DP97
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1298593:TOL RS10340
gene id: 1298593:TOL_RS10340
uniprot id: M5DRM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1298593:TOL RS00705
gene id: 1298593:TOL_RS00705
uniprot id: M5DLF3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1298593:TOL RS15130
gene id: 1298593:TOL_RS15130
uniprot id: M5DVV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS15405
gene id: 1298593:TOL_RS15405
uniprot id: M5E8B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1298593:TOL RS06805
gene id: 1298593:TOL_RS06805
uniprot id: M5DQW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1298593:TOL RS02680
gene id: 1298593:TOL_RS02680
uniprot id: M5DPD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

1298593:TOL RS13545
gene id: 1298593:TOL_RS13545
uniprot id: M5E6W5
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.

1298593:TOL RS14695
gene id: 1298593:TOL_RS14695
uniprot id: M5E7Q7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

1298593:TOL RS15915
gene id: 1298593:TOL_RS15915
uniprot id: M5DUX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

1298593:TOL RS01040
gene id: 1298593:TOL_RS01040
uniprot id: M5DMP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1298593:TOL RS14755
gene id: 1298593:TOL_RS14755
uniprot id: M5DVZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

1298593:TOL RS07630
gene id: 1298593:TOL_RS07630
uniprot id: M5DQ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1298593:TOL RS13315
gene id: 1298593:TOL_RS13315
uniprot id: M5DTC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS11630
gene id: 1298593:TOL_RS11630
uniprot id: M5DTQ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcriptional regulator.

1298593:TOL RS17100
gene id: 1298593:TOL_RS17100
uniprot id: M5DWH5
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

1298593:TOL RS15950
gene id: 1298593:TOL_RS15950
uniprot id: M5DVV2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS13760
gene id: 1298593:TOL_RS13760
uniprot id: M5E717
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

1298593:TOL RS02825
gene id: 1298593:TOL_RS02825
uniprot id: M5DMC4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1298593:TOL RS06640
gene id: 1298593:TOL_RS06640
uniprot id: M5DQL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS03795
gene id: 1298593:TOL_RS03795
uniprot id: M5E0F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS08380
gene id: 1298593:TOL_RS08380
uniprot id: M5DRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS00840
gene id: 1298593:TOL_RS00840
uniprot id: M5DNC6
names: Similarity
messages: Belongs to the RutC family.

1298593:TOL RS04045
gene id: 1298593:TOL_RS04045
uniprot id: M5DPB6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1298593:TOL RS01065
gene id: 1298593:TOL_RS01065
uniprot id: M5DMP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1298593:TOL RS11595
gene id: 1298593:TOL_RS11595
uniprot id: M5E5Q2
names: Similarity
messages: Belongs to the hemerythrin family.

1298593:TOL RS00690
gene id: 1298593:TOL_RS00690
uniprot id: M5DNA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1298593:TOL RS11220
gene id: 1298593:TOL_RS11220
uniprot id: M5DTH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS15175
gene id: 1298593:TOL_RS15175
uniprot id: M5DVX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

1298593:TOL RS15515
gene id: 1298593:TOL_RS15515
uniprot id: M5DW19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1298593:TOL RS06165
gene id: 1298593:TOL_RS06165
uniprot id: M5DQB0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS16425
gene id: 1298593:TOL_RS16425
uniprot id: M5DW31
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS00680
gene id: 1298593:TOL_RS00680
uniprot id: M5DLE9
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1298593:TOL RS03850
gene id: 1298593:TOL_RS03850
uniprot id: M5DPZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1298593:TOL RS09500
gene id: 1298593:TOL_RS09500
uniprot id: M5DSH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS04055
gene id: 1298593:TOL_RS04055
uniprot id: M5DP66
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1298593:TOL RS00785
gene id: 1298593:TOL_RS00785
uniprot id: M5DMP7
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

1298593:TOL RS04960
gene id: 1298593:TOL_RS04960
uniprot id: M5DPX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1298593:TOL RS07855
gene id: 1298593:TOL_RS07855
uniprot id: M5DRL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1298593:TOL RS13400
gene id: 1298593:TOL_RS13400
uniprot id: M5DUG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

1298593:TOL RS04350
gene id: 1298593:TOL_RS04350
uniprot id: M5DPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS17395
gene id: 1298593:TOL_RS17395
uniprot id: M5DVW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

1298593:TOL RS13765
gene id: 1298593:TOL_RS13765
uniprot id: M5DTL5
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1298593:TOL RS14590
gene id: 1298593:TOL_RS14590
uniprot id: M5DV40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1298593:TOL RS00105
gene id: 1298593:TOL_RS00105
uniprot id: M5DL42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

1298593:TOL RS04700
gene id: 1298593:TOL_RS04700
uniprot id: M5DN87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1298593:TOL RS08145
gene id: 1298593:TOL_RS08145
uniprot id: M5DQC2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1298593:TOL RS04570
gene id: 1298593:TOL_RS04570
uniprot id: M5E122
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1298593:TOL RS00150
gene id: 1298593:TOL_RS00150
uniprot id: M5DY81
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.

1298593:TOL RS16695
gene id: 1298593:TOL_RS16695
uniprot id: M5DVE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1298593:TOL RS17005
gene id: 1298593:TOL_RS17005
uniprot id: M5E9A7
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

1298593:TOL RS05170
gene id: 1298593:TOL_RS05170
uniprot id: M5E1M6
names: Similarity
messages: Belongs to the type III secretion exporter family.

1298593:TOL RS00450
gene id: 1298593:TOL_RS00450
uniprot id: M5DMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS00820
gene id: 1298593:TOL_RS00820
uniprot id: M5DMK9
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1298593:TOL RS12845
gene id: 1298593:TOL_RS12845
uniprot id: M5E6H5
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS10010
gene id: 1298593:TOL_RS10010
uniprot id: M5DSU9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1298593:TOL RS10530
gene id: 1298593:TOL_RS10530
uniprot id: M5DT50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1298593:TOL RS06740
gene id: 1298593:TOL_RS06740
uniprot id: M5DQN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1298593:TOL RS12835
gene id: 1298593:TOL_RS12835
uniprot id: M5DV09
names: Similarity
messages: Belongs to the Gfa family.

1298593:TOL RS06115
gene id: 1298593:TOL_RS06115
uniprot id: M5DQ99
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1298593:TOL RS07915
gene id: 1298593:TOL_RS07915
uniprot id: M5DRF7
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

1298593:TOL RS12205
gene id: 1298593:TOL_RS12205
uniprot id: M5DTS9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS10205
gene id: 1298593:TOL_RS10205
uniprot id: M5DSZ7
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1298593:TOL RS09245
gene id: 1298593:TOL_RS09245
uniprot id: M5DQW7
names: Caution
names: Function
names: Similarity
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS00660
gene id: 1298593:TOL_RS00660
uniprot id: M5DLE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1298593:TOL RS16545
gene id: 1298593:TOL_RS16545
uniprot id: M5E8V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1298593:TOL RS10200
gene id: 1298593:TOL_RS10200
uniprot id: M5E502
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS11255
gene id: 1298593:TOL_RS11255
uniprot id: M5DT87
names: Similarity
messages: Belongs to the GST superfamily.

1298593:TOL RS14665
gene id: 1298593:TOL_RS14665
uniprot id: M5DV59
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

1298593:TOL RS16555
gene id: 1298593:TOL_RS16555
uniprot id: M5DWI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1298593:TOL RS02090
gene id: 1298593:TOL_RS02090
uniprot id: M5DP04
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1298593:TOL RS02780
gene id: 1298593:TOL_RS02780
uniprot id: M5DPG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1298593:TOL RS06255
gene id: 1298593:TOL_RS06255
uniprot id: M5DQM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

1298593:TOL RS04595
gene id: 1298593:TOL_RS04595
uniprot id: M5E129
names: Similarity
messages: Belongs to the YfgM family.

1298593:TOL RS12635
gene id: 1298593:TOL_RS12635
uniprot id: M5DSZ1
names: Similarity
messages: Belongs to the PhoH family.

1298593:TOL RS07015
gene id: 1298593:TOL_RS07015
uniprot id: M5DPL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1298593:TOL RS06495
gene id: 1298593:TOL_RS06495
uniprot id: M5DRH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

1298593:TOL RS11265
gene id: 1298593:TOL_RS11265
uniprot id: M5DS30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS15480
gene id: 1298593:TOL_RS15480
uniprot id: M5E8C7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1298593:TOL RS11180
gene id: 1298593:TOL_RS11180
uniprot id: M5DT72
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1298593:TOL RS13875
gene id: 1298593:TOL_RS13875
uniprot id: M5DUP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1298593:TOL RS14625
gene id: 1298593:TOL_RS14625
uniprot id: M5DU56
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS13380
gene id: 1298593:TOL_RS13380
uniprot id: M5DUF8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS12485
gene id: 1298593:TOL_RS12485
uniprot id: M5DSV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1298593:TOL RS02625
gene id: 1298593:TOL_RS02625
uniprot id: M5DM88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MerT family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS05330
gene id: 1298593:TOL_RS05330
uniprot id: M5DQZ4
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1298593:TOL RS16495
gene id: 1298593:TOL_RS16495
uniprot id: M5DWU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS05980
gene id: 1298593:TOL_RS05980
uniprot id: M5DNY7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1298593:TOL RS07210
gene id: 1298593:TOL_RS07210
uniprot id: M5DPR2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1298593:TOL RS05570
gene id: 1298593:TOL_RS05570
uniprot id: M5DQC1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS09400
gene id: 1298593:TOL_RS09400
uniprot id: M5DS57
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1298593:TOL RS08570
gene id: 1298593:TOL_RS08570
uniprot id: M5E3V3
names: Similarity
messages: Belongs to the histone deacetylase family.

1298593:TOL RS00555
gene id: 1298593:TOL_RS00555
uniprot id: M5DMH5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS15625
gene id: 1298593:TOL_RS15625
uniprot id: M5DVQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane
messages: Membrane

1298593:TOL RS11405
gene id: 1298593:TOL_RS11405
uniprot id: M5DS56
names: Similarity
messages: Belongs to the glyoxalase I family.

1298593:TOL RS12760
gene id: 1298593:TOL_RS12760
uniprot id: M5DUZ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1298593:TOL RS16365
gene id: 1298593:TOL_RS16365
uniprot id: M5DWE9
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1298593:TOL RS01765
gene id: 1298593:TOL_RS01765
uniprot id: M5DN31
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1298593:TOL RS14360
gene id: 1298593:TOL_RS14360
uniprot id: M5DVC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

1298593:TOL RS09795
gene id: 1298593:TOL_RS09795
uniprot id: M5DSP7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1298593:TOL RS12780
gene id: 1298593:TOL_RS12780
uniprot id: M5DUJ0
names: Similarity
messages: Belongs to the SUI1 family.

1298593:TOL RS16585
gene id: 1298593:TOL_RS16585
uniprot id: M5DW63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1298593:TOL RS17055
gene id: 1298593:TOL_RS17055
uniprot id: M5E9C3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

1298593:TOL RS12740
gene id: 1298593:TOL_RS12740
uniprot id: M5DUZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1298593:TOL RS02810
gene id: 1298593:TOL_RS02810
uniprot id: M5DPG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1298593:TOL RS02930
gene id: 1298593:TOL_RS02930
uniprot id: M5DPK1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

1298593:TOL RS03520
gene id: 1298593:TOL_RS03520
uniprot id: M5DNY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1298593:TOL RS13885
gene id: 1298593:TOL_RS13885
uniprot id: M5DTN7
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

1298593:TOL RS07835
gene id: 1298593:TOL_RS07835
uniprot id: M5DSC5
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

1298593:TOL RS00615
gene id: 1298593:TOL_RS00615
uniprot id: M5DMM6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1298593:TOL RS14595
gene id: 1298593:TOL_RS14595
uniprot id: M5E7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1298593:TOL RS14570
gene id: 1298593:TOL_RS14570
uniprot id: M5E7L5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1298593:TOL RS11890
gene id: 1298593:TOL_RS11890
uniprot id: M5DTV6
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1298593:TOL RS03150
gene id: 1298593:TOL_RS03150
uniprot id: M5DPN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1298593:TOL RS00005
gene id: 1298593:TOL_RS00005
uniprot id: M5DL16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1298593:TOL RS11400
gene id: 1298593:TOL_RS11400
uniprot id: M5E5L3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1298593:TOL RS07790
gene id: 1298593:TOL_RS07790
uniprot id: M5DRE0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1298593:TOL RS03400
gene id: 1298593:TOL_RS03400
uniprot id: M5DNV9
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

1298593:TOL RS01155
gene id: 1298593:TOL_RS01155
uniprot id: M5DMU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

1298593:TOL RS08885
gene id: 1298593:TOL_RS08885
uniprot id: M5DSS4
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

1298593:TOL RS15305
gene id: 1298593:TOL_RS15305
uniprot id: M5E8A4
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1298593:TOL RS17455
gene id: 1298593:TOL_RS17455
uniprot id: M5DXB6
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1298593:TOL RS13745
gene id: 1298593:TOL_RS13745
uniprot id: M5DV01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1298593:TOL RS06540
gene id: 1298593:TOL_RS06540
uniprot id: M5DRI6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS04675
gene id: 1298593:TOL_RS04675
uniprot id: M5DN81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1298593:TOL RS13575
gene id: 1298593:TOL_RS13575
uniprot id: M5DTH9
names: Similarity
messages: Belongs to the CFA/CMAS family.

1298593:TOL RS02835
gene id: 1298593:TOL_RS02835
uniprot id: M5DPH5
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1298593:TOL RS01545
gene id: 1298593:TOL_RS01545
uniprot id: M5DN05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS13335
gene id: 1298593:TOL_RS13335
uniprot id: M5E6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS06760
gene id: 1298593:TOL_RS06760
uniprot id: M5DRM7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1298593:TOL RS00075
gene id: 1298593:TOL_RS00075
uniprot id: M5DY64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1298593:TOL RS07120
gene id: 1298593:TOL_RS07120
uniprot id: M5DR33
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1298593:TOL RS14220
gene id: 1298593:TOL_RS14220
uniprot id: M5DUW3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS08720
gene id: 1298593:TOL_RS08720
uniprot id: M5DRT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
messages: Cytoplasm

1298593:TOL RS00405
gene id: 1298593:TOL_RS00405
uniprot id: M5DN76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1298593:TOL RS13910
gene id: 1298593:TOL_RS13910
uniprot id: M5DTP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1298593:TOL RS11800
gene id: 1298593:TOL_RS11800
uniprot id: M5DTT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS04450
gene id: 1298593:TOL_RS04450
uniprot id: M5DQA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1298593:TOL RS12825
gene id: 1298593:TOL_RS12825
uniprot id: M5DT46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS11560
gene id: 1298593:TOL_RS11560
uniprot id: M5DU73
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

1298593:TOL RS00790
gene id: 1298593:TOL_RS00790
uniprot id: M5DNC1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1298593:TOL RS12820
gene id: 1298593:TOL_RS12820
uniprot id: M5E6H2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1298593:TOL RS03495
gene id: 1298593:TOL_RS03495
uniprot id: M5DNX5
names: Similarity
messages: Belongs to the PspA/IM30 family.

1298593:TOL RS01160
gene id: 1298593:TOL_RS01160
uniprot id: M5DNG6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

1298593:TOL RS11410
gene id: 1298593:TOL_RS11410
uniprot id: M5DTL3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS12045
gene id: 1298593:TOL_RS12045
uniprot id: M5DUH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1298593:TOL RS12540
gene id: 1298593:TOL_RS12540
uniprot id: M5DUT7
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

1298593:TOL RS08690
gene id: 1298593:TOL_RS08690
uniprot id: M5DSP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

1298593:TOL RS18140
gene id: 1298593:TOL_RS18140
uniprot id: M5DPX9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

1298593:TOL RS13865
gene id: 1298593:TOL_RS13865
uniprot id: M5DV28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1298593:TOL RS04825
gene id: 1298593:TOL_RS04825
uniprot id: M5DNB6
names: Similarity
messages: Belongs to the hyi family.

1298593:TOL RS02770
gene id: 1298593:TOL_RS02770
uniprot id: M5DMB6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1298593:TOL RS16360
gene id: 1298593:TOL_RS16360
uniprot id: M5DV61
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS16885
gene id: 1298593:TOL_RS16885
uniprot id: M5E966
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1298593:TOL RS14560
gene id: 1298593:TOL_RS14560
uniprot id: M5DVV3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1298593:TOL RS00910
gene id: 1298593:TOL_RS00910
uniprot id: M5DMR2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1298593:TOL RS08580
gene id: 1298593:TOL_RS08580
uniprot id: M5DQJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

1298593:TOL RS15010
gene id: 1298593:TOL_RS15010
uniprot id: M5DVS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

1298593:TOL RS01235
gene id: 1298593:TOL_RS01235
uniprot id: M5DMS3
names: Similarity
messages: Belongs to the DEAD box helicase family.

1298593:TOL RS04795
gene id: 1298593:TOL_RS04795
uniprot id: M5E188
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

1298593:TOL RS05470
gene id: 1298593:TOL_RS05470
uniprot id: M5DR19
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

1298593:TOL RS05920
gene id: 1298593:TOL_RS05920
uniprot id: M5DR81
names: Similarity
messages: Belongs to the YoeB family.

1298593:TOL RS08310
gene id: 1298593:TOL_RS08310
uniprot id: M5DRU8
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS15105
gene id: 1298593:TOL_RS15105
uniprot id: M5DVU6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1298593:TOL RS16520
gene id: 1298593:TOL_RS16520
uniprot id: M5DW48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1298593:TOL RS14895
gene id: 1298593:TOL_RS14895
uniprot id: M5DVB5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1298593:TOL RS16560
gene id: 1298593:TOL_RS16560
uniprot id: M5DW59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1298593:TOL RS02840
gene id: 1298593:TOL_RS02840
uniprot id: M5DNK9
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1298593:TOL RS09990
gene id: 1298593:TOL_RS09990
uniprot id: M5DTF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1298593:TOL RS01950
gene id: 1298593:TOL_RS01950
uniprot id: M5DZA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1298593:TOL RS03300
gene id: 1298593:TOL_RS03300
uniprot id: M5DNU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

1298593:TOL RS06890
gene id: 1298593:TOL_RS06890
uniprot id: M5E2P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1298593:TOL RS13870
gene id: 1298593:TOL_RS13870
uniprot id: M5DVG5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1298593:TOL RS13795
gene id: 1298593:TOL_RS13795
uniprot id: M5DV11
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1298593:TOL RS16690
gene id: 1298593:TOL_RS16690
uniprot id: M5E8Z9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1298593:TOL RS11855
gene id: 1298593:TOL_RS11855
uniprot id: M5E5V4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1298593:TOL RS03020
gene id: 1298593:TOL_RS03020
uniprot id: M5DNR5
names: Function
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.

1298593:TOL RS01115
gene id: 1298593:TOL_RS01115
uniprot id: M5DMQ6
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS10015
gene id: 1298593:TOL_RS10015
uniprot id: M5DTF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1298593:TOL RS03395
gene id: 1298593:TOL_RS03395
uniprot id: M5DPS0
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1298593:TOL RS16620
gene id: 1298593:TOL_RS16620
uniprot id: M5DVC5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1298593:TOL RS03370
gene id: 1298593:TOL_RS03370
uniprot id: M5DPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS02145
gene id: 1298593:TOL_RS02145
uniprot id: M5DN61
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1298593:TOL RS04565
gene id: 1298593:TOL_RS04565
uniprot id: M5DPH1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1298593:TOL RS01150
gene id: 1298593:TOL_RS01150
uniprot id: M5DLL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS07400
gene id: 1298593:TOL_RS07400
uniprot id: M5DR99
names: Similarity
messages: Belongs to the TrpF family.

1298593:TOL RS03340
gene id: 1298593:TOL_RS03340
uniprot id: M5DNX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1298593:TOL RS10320
gene id: 1298593:TOL_RS10320
uniprot id: M5DT22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1298593:TOL RS03410
gene id: 1298593:TOL_RS03410
uniprot id: M5DML2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1298593:TOL RS17045
gene id: 1298593:TOL_RS17045
uniprot id: M5DX39
names: Similarity
messages: Belongs to the YggT family.

1298593:TOL RS15875
gene id: 1298593:TOL_RS15875
uniprot id: M5DWL0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS08620
gene id: 1298593:TOL_RS08620
uniprot id: M5DRR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1298593:TOL RS13960
gene id: 1298593:TOL_RS13960
uniprot id: M5DTQ0
names: Similarity
messages: Belongs to the UPF0250 family.

1298593:TOL RS07770
gene id: 1298593:TOL_RS07770
uniprot id: M5DRD5
names: Similarity
messages: Belongs to the MlaA family.

1298593:TOL RS04260
gene id: 1298593:TOL_RS04260
uniprot id: M5DPG4
names: Similarity
messages: Belongs to the TonB-dependent receptor family.

1298593:TOL RS03160
gene id: 1298593:TOL_RS03160
uniprot id: M5E027
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS10185
gene id: 1298593:TOL_RS10185
uniprot id: M5DSZ2
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1298593:TOL RS05380
gene id: 1298593:TOL_RS05380
uniprot id: M5DR03
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1298593:TOL RS01295
gene id: 1298593:TOL_RS01295
uniprot id: M5DMW7
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1298593:TOL RS03860
gene id: 1298593:TOL_RS03860
uniprot id: M5E0H4
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

1298593:TOL RS09455
gene id: 1298593:TOL_RS09455
uniprot id: M5DT29
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1298593:TOL RS17265
gene id: 1298593:TOL_RS17265
uniprot id: M5DWL3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS15155
gene id: 1298593:TOL_RS15155
uniprot id: M5DWB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1298593:TOL RS09145
gene id: 1298593:TOL_RS09145
uniprot id: M5DSX1
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1298593:TOL RS04905
gene id: 1298593:TOL_RS04905
uniprot id: M5DQM9
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1298593:TOL RS12000
gene id: 1298593:TOL_RS12000
uniprot id: M5DTM6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1298593:TOL RS04050
gene id: 1298593:TOL_RS04050
uniprot id: M5DQ24
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1298593:TOL RS10980
gene id: 1298593:TOL_RS10980
uniprot id: M5DT27
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1298593:TOL RS16175
gene id: 1298593:TOL_RS16175
uniprot id: M5DWQ2
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1298593:TOL RS13895
gene id: 1298593:TOL_RS13895
uniprot id: M5DVH0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1298593:TOL RS14450
gene id: 1298593:TOL_RS14450
uniprot id: M5E7H6
names: Similarity
messages: Belongs to the SfsA family.

1298593:TOL RS01280
gene id: 1298593:TOL_RS01280
uniprot id: M5DMS9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1298593:TOL RS04860
gene id: 1298593:TOL_RS04860
uniprot id: M5DPM4
names: Similarity
messages: Belongs to the FeoA family.

1298593:TOL RS16655
gene id: 1298593:TOL_RS16655
uniprot id: M5DWX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1298593:TOL RS14430
gene id: 1298593:TOL_RS14430
uniprot id: M5DU06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1298593:TOL RS07225
gene id: 1298593:TOL_RS07225
uniprot id: M5DQZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1298593:TOL RS01730
gene id: 1298593:TOL_RS01730
uniprot id: M5DLU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1298593:TOL RS03335
gene id: 1298593:TOL_RS03335
uniprot id: M5DMK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

1298593:TOL RS04480
gene id: 1298593:TOL_RS04480
uniprot id: M5DPE9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1298593:TOL RS15220
gene id: 1298593:TOL_RS15220
uniprot id: M5DUL4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS04155
gene id: 1298593:TOL_RS04155
uniprot id: M5DP81
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1298593:TOL RS08670
gene id: 1298593:TOL_RS08670
uniprot id: M5DRS5
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1298593:TOL RS09735
gene id: 1298593:TOL_RS09735
uniprot id: M5E4K7
names: Similarity
messages: Belongs to the BolA/IbaG family.

1298593:TOL RS00870
gene id: 1298593:TOL_RS00870
uniprot id: M5DML8
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

1298593:TOL RS01695
gene id: 1298593:TOL_RS01695
uniprot id: M5DMY8
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1298593:TOL RS03425
gene id: 1298593:TOL_RS03425
uniprot id: M5DNW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

1298593:TOL RS12940
gene id: 1298593:TOL_RS12940
uniprot id: M5DU92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

1298593:TOL RS06095
gene id: 1298593:TOL_RS06095
uniprot id: M5E283
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1298593:TOL RS07360
gene id: 1298593:TOL_RS07360
uniprot id: M5DR28
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1298593:TOL RS00850
gene id: 1298593:TOL_RS00850
uniprot id: M5DYM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1298593:TOL RS14645
gene id: 1298593:TOL_RS14645
uniprot id: M5E7N6
names: Similarity
messages: Belongs to the MotB family.

1298593:TOL RS14400
gene id: 1298593:TOL_RS14400
uniprot id: M5E7G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS08505
gene id: 1298593:TOL_RS08505
uniprot id: M5E3U3
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1298593:TOL RS03365
gene id: 1298593:TOL_RS03365
uniprot id: M5DNX6
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1298593:TOL RS14495
gene id: 1298593:TOL_RS14495
uniprot id: M5DV17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1298593:TOL RS12100
gene id: 1298593:TOL_RS12100
uniprot id: M5DTQ1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1298593:TOL RS18305
gene id: 1298593:TOL_RS18305
uniprot id: M5E3T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP M family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

1298593:TOL RS12320
gene id: 1298593:TOL_RS12320
uniprot id: M5DSQ9
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1298593:TOL RS11020
gene id: 1298593:TOL_RS11020
uniprot id: M5DTE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1298593:TOL RS05200
gene id: 1298593:TOL_RS05200
uniprot id: M5DNI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

1298593:TOL RS11335
gene id: 1298593:TOL_RS11335
uniprot id: M5E5J7
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1298593:TOL RS12220
gene id: 1298593:TOL_RS12220
uniprot id: M5DU33
names: Similarity
names: Subunit
messages: Belongs to the FliD family.
messages: Homopentamer.

1298593:TOL RS04000
gene id: 1298593:TOL_RS04000
uniprot id: M5DP57
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1298593:TOL RS08820
gene id: 1298593:TOL_RS08820
uniprot id: M5E406
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

1298593:TOL RS18410
gene id: 1298593:TOL_RS18410
uniprot id: M5DTK6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1298593:TOL RS10265
gene id: 1298593:TOL_RS10265
uniprot id: M5DTL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1298593:TOL RS03605
gene id: 1298593:TOL_RS03605
uniprot id: M5DMP8
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

1298593:TOL RS15320
gene id: 1298593:TOL_RS15320
uniprot id: M5DWD7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS05215
gene id: 1298593:TOL_RS05215
uniprot id: M5DPV4
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

1298593:TOL RS12490
gene id: 1298593:TOL_RS12490
uniprot id: M5DUB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1298593:TOL RS11915
gene id: 1298593:TOL_RS11915
uniprot id: M5DTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

1298593:TOL RS04870
gene id: 1298593:TOL_RS04870
uniprot id: M5DNC2
names: Subcellular Location Annotation
messages: Cytoplasm

1298593:TOL RS02935
gene id: 1298593:TOL_RS02935
uniprot id: M5DNN5
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

1298593:TOL RS13965
gene id: 1298593:TOL_RS13965
uniprot id: M5DV47
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1298593:TOL RS03685
gene id: 1298593:TOL_RS03685
uniprot id: M5DPW4
names: Similarity
messages: Belongs to the MQO family.

1298593:TOL RS14410
gene id: 1298593:TOL_RS14410
uniprot id: M5DVD5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1298593:TOL RS00855
gene id: 1298593:TOL_RS00855
uniprot id: M5DLH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1298593:TOL RS14155
gene id: 1298593:TOL_RS14155
uniprot id: M5DV83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1298593:TOL RS04835
gene id: 1298593:TOL_RS04835
uniprot id: M5DQL1
names: Subcellular Location Annotation
messages: Cytoplasm

1298593:TOL RS01400
gene id: 1298593:TOL_RS01400
uniprot id: M5DNL0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS08200
gene id: 1298593:TOL_RS08200
uniprot id: M5DRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1298593:TOL RS07780
gene id: 1298593:TOL_RS07780
uniprot id: M5DRK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS17370
gene id: 1298593:TOL_RS17370
uniprot id: M5DVW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1298593:TOL RS12260
gene id: 1298593:TOL_RS12260
uniprot id: M5E643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1298593:TOL RS17310
gene id: 1298593:TOL_RS17310
uniprot id: M5DX89
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

1298593:TOL RS15215
gene id: 1298593:TOL_RS15215
uniprot id: M5E888
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1298593:TOL RS16140
gene id: 1298593:TOL_RS16140
uniprot id: M5DV18
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1298593:TOL RS17520
gene id: 1298593:TOL_RS17520
uniprot id: M5DVZ9
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS13655
gene id: 1298593:TOL_RS13655
uniprot id: M5DVD0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1298593:TOL RS17215
gene id: 1298593:TOL_RS17215
uniprot id: M5DX74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

1298593:TOL RS15565
gene id: 1298593:TOL_RS15565
uniprot id: M5DW26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS01540
gene id: 1298593:TOL_RS01540
uniprot id: M5DLS2
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS03765
gene id: 1298593:TOL_RS03765
uniprot id: M5DP18
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1298593:TOL RS08550
gene id: 1298593:TOL_RS08550
uniprot id: M5DQI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1298593:TOL RS06025
gene id: 1298593:TOL_RS06025
uniprot id: M5DNZ7
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

1298593:TOL RS08650
gene id: 1298593:TOL_RS08650
uniprot id: M5E3W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1298593:TOL RS14775
gene id: 1298593:TOL_RS14775
uniprot id: M5DVL6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1298593:TOL RS16720
gene id: 1298593:TOL_RS16720
uniprot id: M5DVF2
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1298593:TOL RS05095
gene id: 1298593:TOL_RS05095
uniprot id: M5E1K3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1298593:TOL RS06055
gene id: 1298593:TOL_RS06055
uniprot id: M5DQJ5
names: Similarity
messages: Belongs to the pirin family.

1298593:TOL RS14440
gene id: 1298593:TOL_RS14440
uniprot id: M5DVS7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1298593:TOL RS13135
gene id: 1298593:TOL_RS13135
uniprot id: M5DV50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1298593:TOL RS11345
gene id: 1298593:TOL_RS11345
uniprot id: M5DTK0
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1298593:TOL RS03185
gene id: 1298593:TOL_RS03185
uniprot id: M5DMI4
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS15570
gene id: 1298593:TOL_RS15570
uniprot id: M5DWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS03845
gene id: 1298593:TOL_RS03845
uniprot id: M5DP77
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1298593:TOL RS15975
gene id: 1298593:TOL_RS15975
uniprot id: M5DVV4
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1298593:TOL RS17295
gene id: 1298593:TOL_RS17295
uniprot id: M5E9J3
names: Similarity
messages: Belongs to the GSP E family.

1298593:TOL RS14750
gene id: 1298593:TOL_RS14750
uniprot id: M5DVK8
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1298593:TOL RS11885
gene id: 1298593:TOL_RS11885
uniprot id: M5DSG0
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

1298593:TOL RS08095
gene id: 1298593:TOL_RS08095
uniprot id: M5DQB3
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1298593:TOL RS15900
gene id: 1298593:TOL_RS15900
uniprot id: M5DWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS03350
gene id: 1298593:TOL_RS03350
uniprot id: M5DNV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1298593:TOL RS04020
gene id: 1298593:TOL_RS04020
uniprot id: M5DQ21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1298593:TOL RS11555
gene id: 1298593:TOL_RS11555
uniprot id: M5DTN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

1298593:TOL RS15835
gene id: 1298593:TOL_RS15835
uniprot id: M5E8H5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

1298593:TOL RS17850
gene id: 1298593:TOL_RS17850
uniprot id: M5EA03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1298593:TOL RS12375
gene id: 1298593:TOL_RS12375
uniprot id: M5DU78
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1298593:TOL RS13630
gene id: 1298593:TOL_RS13630
uniprot id: M5DVC6
names: Similarity
messages: Belongs to the UPF0234 family.

1298593:TOL RS11640
gene id: 1298593:TOL_RS11640
uniprot id: M5DTG1
names: Similarity
messages: Belongs to the creatininase superfamily.

1298593:TOL RS13810
gene id: 1298593:TOL_RS13810
uniprot id: M5E727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1298593:TOL RS02645
gene id: 1298593:TOL_RS02645
uniprot id: M5DM92
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS08640
gene id: 1298593:TOL_RS08640
uniprot id: M5DSN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1298593:TOL RS02965
gene id: 1298593:TOL_RS02965
uniprot id: M5DZZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1298593:TOL RS13235
gene id: 1298593:TOL_RS13235
uniprot id: M5DUD5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS11340
gene id: 1298593:TOL_RS11340
uniprot id: M5DS43
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1298593:TOL RS03095
gene id: 1298593:TOL_RS03095
uniprot id: M5DNS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

1298593:TOL RS05030
gene id: 1298593:TOL_RS05030
uniprot id: M5DNE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS07095
gene id: 1298593:TOL_RS07095
uniprot id: M5DR27
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

1298593:TOL RS11905
gene id: 1298593:TOL_RS11905
uniprot id: M5E5W5
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1298593:TOL RS14630
gene id: 1298593:TOL_RS14630
uniprot id: M5DVI1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1298593:TOL RS14585
gene id: 1298593:TOL_RS14585
uniprot id: M5DVV7
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1298593:TOL RS04585
gene id: 1298593:TOL_RS04585
uniprot id: M5DQE5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1298593:TOL RS02500
gene id: 1298593:TOL_RS02500
uniprot id: M5DZN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
messages: Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS00215
gene id: 1298593:TOL_RS00215
uniprot id: M5DMB1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS11875
gene id: 1298593:TOL_RS11875
uniprot id: M5DTK4
names: Similarity
messages: Belongs to the UPF0438 family.

1298593:TOL RS09355
gene id: 1298593:TOL_RS09355
uniprot id: M5DT12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS10675
gene id: 1298593:TOL_RS10675
uniprot id: M5DRT2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1298593:TOL RS04455
gene id: 1298593:TOL_RS04455
uniprot id: M5DPE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1298593:TOL RS06065
gene id: 1298593:TOL_RS06065
uniprot id: M5DQ89
names: Similarity
messages: Belongs to the DEAD box helicase family.

1298593:TOL RS16600
gene id: 1298593:TOL_RS16600
uniprot id: M5DWJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1298593:TOL RS14530
gene id: 1298593:TOL_RS14530
uniprot id: M5DU32
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

1298593:TOL RS01300
gene id: 1298593:TOL_RS01300
uniprot id: M5DNJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1298593:TOL RS05715
gene id: 1298593:TOL_RS05715
uniprot id: M5DNT0
names: Similarity
messages: Belongs to the Gfa family.

1298593:TOL RS01185
gene id: 1298593:TOL_RS01185
uniprot id: M5DNH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS00570
gene id: 1298593:TOL_RS00570
uniprot id: M5DN97
names: Similarity
messages: Belongs to the DprA/Smf family.

1298593:TOL RS13150
gene id: 1298593:TOL_RS13150
uniprot id: M5DT98
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS07935
gene id: 1298593:TOL_RS07935
uniprot id: M5DSE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1298593:TOL RS15870
gene id: 1298593:TOL_RS15870
uniprot id: M5DW67
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS13515
gene id: 1298593:TOL_RS13515
uniprot id: M5DUH8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1298593:TOL RS06855
gene id: 1298593:TOL_RS06855
uniprot id: M5DQX8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1298593:TOL RS00610
gene id: 1298593:TOL_RS00610
uniprot id: M5DLD8
names: Similarity
messages: Belongs to the universal stress protein A family.

1298593:TOL RS04710
gene id: 1298593:TOL_RS04710
uniprot id: M5DQH9
names: Similarity
messages: Belongs to the UPF0047 family.

1298593:TOL RS15585
gene id: 1298593:TOL_RS15585
uniprot id: M5DUS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1298593:TOL RS12050
gene id: 1298593:TOL_RS12050
uniprot id: M5DTN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1298593:TOL RS03000
gene id: 1298593:TOL_RS03000
uniprot id: M5DPL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

1298593:TOL RS06160
gene id: 1298593:TOL_RS06160
uniprot id: M5DRB9
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS14620
gene id: 1298593:TOL_RS14620
uniprot id: M5E7M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1298593:TOL RS09130
gene id: 1298593:TOL_RS09130
uniprot id: M5DS10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1298593:TOL RS06560
gene id: 1298593:TOL_RS06560
uniprot id: M5DQS1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS16590
gene id: 1298593:TOL_RS16590
uniprot id: M5E8W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1298593:TOL RS11025
gene id: 1298593:TOL_RS11025
uniprot id: M5DTZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1298593:TOL RS14040
gene id: 1298593:TOL_RS14040
uniprot id: M5DV62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

1298593:TOL RS03885
gene id: 1298593:TOL_RS03885
uniprot id: M5E0I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

1298593:TOL RS03660
gene id: 1298593:TOL_RS03660
uniprot id: M5DPW0
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS11810
gene id: 1298593:TOL_RS11810
uniprot id: M5DTJ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1298593:TOL RS01080
gene id: 1298593:TOL_RS01080
uniprot id: M5DMT3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1298593:TOL RS01455
gene id: 1298593:TOL_RS01455
uniprot id: M5DMV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1298593:TOL RS17935
gene id: 1298593:TOL_RS17935
uniprot id: M5DXE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

1298593:TOL RS02175
gene id: 1298593:TOL_RS02175
uniprot id: M5DZF7
names: Similarity
messages: Belongs to the aspartokinase family.

1298593:TOL RS04855
gene id: 1298593:TOL_RS04855
uniprot id: M5DQL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1298593:TOL RS15385
gene id: 1298593:TOL_RS15385
uniprot id: M5DUP5
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1298593:TOL RS11895
gene id: 1298593:TOL_RS11895
uniprot id: M5DUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1298593:TOL RS17160
gene id: 1298593:TOL_RS17160
uniprot id: M5DWV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1298593:TOL RS09865
gene id: 1298593:TOL_RS09865
uniprot id: M5DSR2
names: Similarity
messages: Belongs to the DEAD box helicase family.

1298593:TOL RS05355
gene id: 1298593:TOL_RS05355
uniprot id: M5DQZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS06845
gene id: 1298593:TOL_RS06845
uniprot id: M5E2M8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1298593:TOL RS00860
gene id: 1298593:TOL_RS00860
uniprot id: M5DMQ5
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1298593:TOL RS17550
gene id: 1298593:TOL_RS17550
uniprot id: M5DX52
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1298593:TOL RS05390
gene id: 1298593:TOL_RS05390
uniprot id: M5E1X2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

1298593:TOL RS03485
gene id: 1298593:TOL_RS03485
uniprot id: M5DP00
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

1298593:TOL RS12995
gene id: 1298593:TOL_RS12995
uniprot id: M5E6K0
names: Function
names: Similarity
messages: Belongs to the Dus family. DusC subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.

1298593:TOL RS17845
gene id: 1298593:TOL_RS17845
uniprot id: M5DWY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1298593:TOL RS08510
gene id: 1298593:TOL_RS08510
uniprot id: M5DQI5
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

1298593:TOL RS17000
gene id: 1298593:TOL_RS17000
uniprot id: M5DWF2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1298593:TOL RS08610
gene id: 1298593:TOL_RS08610
uniprot id: M5DRZ5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1298593:TOL RS12280
gene id: 1298593:TOL_RS12280
uniprot id: M5DTU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1298593:TOL RS09175
gene id: 1298593:TOL_RS09175
uniprot id: M5DS18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1298593:TOL RS15905
gene id: 1298593:TOL_RS15905
uniprot id: M5DVU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS08965
gene id: 1298593:TOL_RS08965
uniprot id: M5E439
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS10840
gene id: 1298593:TOL_RS10840
uniprot id: M5DTA7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1298593:TOL RS11030
gene id: 1298593:TOL_RS11030
uniprot id: M5DT36
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1298593:TOL RS09290
gene id: 1298593:TOL_RS09290
uniprot id: M5DQX7
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS03430
gene id: 1298593:TOL_RS03430
uniprot id: M5E074
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1298593:TOL RS09660
gene id: 1298593:TOL_RS09660
uniprot id: M5E4J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1298593:TOL RS13430
gene id: 1298593:TOL_RS13430
uniprot id: M5E6T7
names: Similarity
messages: Belongs to the glutamate synthase family.

1298593:TOL RS00825
gene id: 1298593:TOL_RS00825
uniprot id: M5DYM3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS02525
gene id: 1298593:TOL_RS02525
uniprot id: M5DZN9
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1298593:TOL RS12850
gene id: 1298593:TOL_RS12850
uniprot id: M5DT51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

1298593:TOL RS07545
gene id: 1298593:TOL_RS07545
uniprot id: M5DS63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

1298593:TOL RS16660
gene id: 1298593:TOL_RS16660
uniprot id: M5DW83
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1298593:TOL RS08370
gene id: 1298593:TOL_RS08370
uniprot id: M5E3R8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1298593:TOL RS09630
gene id: 1298593:TOL_RS09630
uniprot id: M5DSA4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

1298593:TOL RS04345
gene id: 1298593:TOL_RS04345
uniprot id: M5DN22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS10540
gene id: 1298593:TOL_RS10540
uniprot id: M5DSW2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1298593:TOL RS15250
gene id: 1298593:TOL_RS15250
uniprot id: M5DVY3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1298593:TOL RS15555
gene id: 1298593:TOL_RS15555
uniprot id: M5E8D8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1298593:TOL RS12040
gene id: 1298593:TOL_RS12040
uniprot id: M5DTY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1298593:TOL RS09030
gene id: 1298593:TOL_RS09030
uniprot id: M5DRZ1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1298593:TOL RS04685
gene id: 1298593:TOL_RS04685
uniprot id: M5DQH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1298593:TOL RS15825
gene id: 1298593:TOL_RS15825
uniprot id: M5DWK3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

1298593:TOL RS08595
gene id: 1298593:TOL_RS08595
uniprot id: M5DRQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

1298593:TOL RS06400
gene id: 1298593:TOL_RS06400
uniprot id: M5DP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1298593:TOL RS04790
gene id: 1298593:TOL_RS04790
uniprot id: M5DPK8
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

1298593:TOL RS03650
gene id: 1298593:TOL_RS03650
uniprot id: M5E0B6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS06590
gene id: 1298593:TOL_RS06590
uniprot id: M5DQS6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1298593:TOL RS16615
gene id: 1298593:TOL_RS16615
uniprot id: M5E8X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1298593:TOL RS12855
gene id: 1298593:TOL_RS12855
uniprot id: M5DUK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

1298593:TOL RS08005
gene id: 1298593:TOL_RS08005
uniprot id: M5DRP1
names: Similarity
messages: Belongs to the peptidase M16 family.

1298593:TOL RS15725
gene id: 1298593:TOL_RS15725
uniprot id: M5DWI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1298593:TOL RS17545
gene id: 1298593:TOL_RS17545
uniprot id: M5DW04
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

1298593:TOL RS00720
gene id: 1298593:TOL_RS00720
uniprot id: M5DMJ6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1298593:TOL RS13790
gene id: 1298593:TOL_RS13790
uniprot id: M5DTM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1298593:TOL RS13920
gene id: 1298593:TOL_RS13920
uniprot id: M5DVH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1298593:TOL RS00545
gene id: 1298593:TOL_RS00545
uniprot id: M5DML6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1298593:TOL RS01000
gene id: 1298593:TOL_RS01000
uniprot id: M5DYQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoid occlusion factor SlmA family.
messages: Homodimer. Interacts with FtsZ.
messages: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
messages: nucleoid

1298593:TOL RS13340
gene id: 1298593:TOL_RS13340
uniprot id: M5DTD3
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1298593:TOL RS07890
gene id: 1298593:TOL_RS07890
uniprot id: M5DRF3
names: Similarity
messages: Belongs to the PrpF family.

1298593:TOL RS03855
gene id: 1298593:TOL_RS03855
uniprot id: M5DP32
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS04760
gene id: 1298593:TOL_RS04760
uniprot id: M5DQJ1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1298593:TOL RS07950
gene id: 1298593:TOL_RS07950
uniprot id: M5DQ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1298593:TOL RS03910
gene id: 1298593:TOL_RS03910
uniprot id: M5E0I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1298593:TOL RS04080
gene id: 1298593:TOL_RS04080
uniprot id: M5DP70
names: Similarity
messages: Belongs to the UPF0102 family.

1298593:TOL RS03970
gene id: 1298593:TOL_RS03970
uniprot id: M5DPA3
names: Similarity
messages: Belongs to the PhoH family.

1298593:TOL RS18340
gene id: 1298593:TOL_RS18340
uniprot id: M5DT52
names: Subcellular Location Annotation
messages: Cell inner membrane

1298593:TOL RS07070
gene id: 1298593:TOL_RS07070
uniprot id: M5DR22
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1298593:TOL RS16650
gene id: 1298593:TOL_RS16650
uniprot id: M5DWK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1298593:TOL RS14165
gene id: 1298593:TOL_RS14165
uniprot id: M5DUV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

1298593:TOL RS17305
gene id: 1298593:TOL_RS17305
uniprot id: M5DWY5
names: Similarity
messages: Belongs to the peptidase M20A family. ArgE subfamily.

1298593:TOL RS15730
gene id: 1298593:TOL_RS15730
uniprot id: M5DVR9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS16995
gene id: 1298593:TOL_RS16995
uniprot id: M5DX31
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1298593:TOL RS05690
gene id: 1298593:TOL_RS05690
uniprot id: M5DNS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1298593:TOL RS03780
gene id: 1298593:TOL_RS03780
uniprot id: M5DP63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS12990
gene id: 1298593:TOL_RS12990
uniprot id: M5DU99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

1298593:TOL RS09055
gene id: 1298593:TOL_RS09055
uniprot id: M5DRZ6
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1298593:TOL RS02970
gene id: 1298593:TOL_RS02970
uniprot id: M5DMF4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1298593:TOL RS11060
gene id: 1298593:TOL_RS11060
uniprot id: M5E5E2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

1298593:TOL RS16150
gene id: 1298593:TOL_RS16150
uniprot id: M5DWP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1298593:TOL RS07140
gene id: 1298593:TOL_RS07140
uniprot id: M5DPP6
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS00600
gene id: 1298593:TOL_RS00600
uniprot id: M5DMI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS08500
gene id: 1298593:TOL_RS08500
uniprot id: M5DRP3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1298593:TOL RS09820
gene id: 1298593:TOL_RS09820
uniprot id: M5DSQ2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS12160
gene id: 1298593:TOL_RS12160
uniprot id: M5DSM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

1298593:TOL RS16375
gene id: 1298593:TOL_RS16375
uniprot id: M5DW22
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1298593:TOL RS15420
gene id: 1298593:TOL_RS15420
uniprot id: M5DWF1
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

1298593:TOL RS11045
gene id: 1298593:TOL_RS11045
uniprot id: M5DTE4
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS04650
gene id: 1298593:TOL_RS04650
uniprot id: M5DN77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1298593:TOL RS16120
gene id: 1298593:TOL_RS16120
uniprot id: M5DWA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS07650
gene id: 1298593:TOL_RS07650
uniprot id: M5E3C7
names: Similarity
messages: Belongs to the UPF0260 family.

1298593:TOL RS04295
gene id: 1298593:TOL_RS04295
uniprot id: M5E0T6
names: Similarity
messages: Belongs to the YjdM family.

1298593:TOL RS16550
gene id: 1298593:TOL_RS16550
uniprot id: M5DVA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1298593:TOL RS01925
gene id: 1298593:TOL_RS01925
uniprot id: M5DZ95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1298593:TOL RS07940
gene id: 1298593:TOL_RS07940
uniprot id: M5DRG1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1298593:TOL RS15400
gene id: 1298593:TOL_RS15400
uniprot id: M5DVM6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

1298593:TOL RS00845
gene id: 1298593:TOL_RS00845
uniprot id: M5DML5
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1298593:TOL RS03245
gene id: 1298593:TOL_RS03245
uniprot id: M5DPP8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS05340
gene id: 1298593:TOL_RS05340
uniprot id: M5E1W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1298593:TOL RS13090
gene id: 1298593:TOL_RS13090
uniprot id: M5DUB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1298593:TOL RS10170
gene id: 1298593:TOL_RS10170
uniprot id: M5DSN8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1298593:TOL RS12285
gene id: 1298593:TOL_RS12285
uniprot id: M5E649
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1298593:TOL RS14465
gene id: 1298593:TOL_RS14465
uniprot id: M5DVT2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS14210
gene id: 1298593:TOL_RS14210
uniprot id: M5DV91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

1298593:TOL RS09230
gene id: 1298593:TOL_RS09230
uniprot id: M5DSY8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS16490
gene id: 1298593:TOL_RS16490
uniprot id: M5DWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1298593:TOL RS17030
gene id: 1298593:TOL_RS17030
uniprot id: M5E9B4
names: Similarity
messages: Belongs to the GSP E family.

1298593:TOL RS16935
gene id: 1298593:TOL_RS16935
uniprot id: M5DVI9
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS11250
gene id: 1298593:TOL_RS11250
uniprot id: M5DU24
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS01505
gene id: 1298593:TOL_RS01505
uniprot id: M5DMW2
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS13190
gene id: 1298593:TOL_RS13190
uniprot id: M5DUC7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS17815
gene id: 1298593:TOL_RS17815
uniprot id: M5DXJ4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS06145
gene id: 1298593:TOL_RS06145
uniprot id: M5E291
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1298593:TOL RS17480
gene id: 1298593:TOL_RS17480
uniprot id: M5DWQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1298593:TOL RS08120
gene id: 1298593:TOL_RS08120
uniprot id: M5DQB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1298593:TOL RS07385
gene id: 1298593:TOL_RS07385
uniprot id: M5DR34
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS02115
gene id: 1298593:TOL_RS02115
uniprot id: M5DP11
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS10770
gene id: 1298593:TOL_RS10770
uniprot id: M5DT92
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1298593:TOL RS17475
gene id: 1298593:TOL_RS17475
uniprot id: M5DXC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1298593:TOL RS07215
gene id: 1298593:TOL_RS07215
uniprot id: M5DR56
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1298593:TOL RS00980
gene id: 1298593:TOL_RS00980
uniprot id: M5DLI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1298593:TOL RS11585
gene id: 1298593:TOL_RS11585
uniprot id: M5DU77
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

1298593:TOL RS01395
gene id: 1298593:TOL_RS01395
uniprot id: M5DMY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1298593:TOL RS12465
gene id: 1298593:TOL_RS12465
uniprot id: M5DSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

1298593:TOL RS15660
gene id: 1298593:TOL_RS15660
uniprot id: M5DUU0
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1298593:TOL RS09070
gene id: 1298593:TOL_RS09070
uniprot id: M5DS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS03695
gene id: 1298593:TOL_RS03695
uniprot id: M5E0C5
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS17210
gene id: 1298593:TOL_RS17210
uniprot id: M5DWW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

1298593:TOL RS07310
gene id: 1298593:TOL_RS07310
uniprot id: M5DS11
names: Similarity
messages: Belongs to the pirin family.

1298593:TOL RS10550
gene id: 1298593:TOL_RS10550
uniprot id: M5DRR1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1298593:TOL RS08625
gene id: 1298593:TOL_RS08625
uniprot id: M5E3W4
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

1298593:TOL RS00375
gene id: 1298593:TOL_RS00375
uniprot id: M5DMH6
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1298593:TOL RS12270
gene id: 1298593:TOL_RS12270
uniprot id: M5DU45
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1298593:TOL RS11350
gene id: 1298593:TOL_RS11350
uniprot id: M5DU41
names: Similarity
messages: Belongs to the HesB/IscA family.

1298593:TOL RS05370
gene id: 1298593:TOL_RS05370
uniprot id: M5DNM3
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS13145
gene id: 1298593:TOL_RS13145
uniprot id: M5E6N0
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1298593:TOL RS06875
gene id: 1298593:TOL_RS06875
uniprot id: M5DQY1
names: Similarity
messages: Belongs to the MQO family.

1298593:TOL RS00015
gene id: 1298593:TOL_RS00015
uniprot id: M5DN01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1298593:TOL RS07720
gene id: 1298593:TOL_RS07720
uniprot id: M5DRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS02170
gene id: 1298593:TOL_RS02170
uniprot id: M5DN66
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1298593:TOL RS08800
gene id: 1298593:TOL_RS08800
uniprot id: M5DQN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1298593:TOL RS07195
gene id: 1298593:TOL_RS07195
uniprot id: M5DRY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS11385
gene id: 1298593:TOL_RS11385
uniprot id: M5DS51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS13880
gene id: 1298593:TOL_RS13880
uniprot id: M5E743
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1298593:TOL RS11440
gene id: 1298593:TOL_RS11440
uniprot id: M5DU55
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1298593:TOL RS11650
gene id: 1298593:TOL_RS11650
uniprot id: M5DSA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1298593:TOL RS17180
gene id: 1298593:TOL_RS17180
uniprot id: M5DVR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1298593:TOL RS11565
gene id: 1298593:TOL_RS11565
uniprot id: M5DTE8
names: Similarity
messages: Belongs to the UPF0231 family.

1298593:TOL RS00245
gene id: 1298593:TOL_RS00245
uniprot id: M5DYA6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1298593:TOL RS07305
gene id: 1298593:TOL_RS07305
uniprot id: M5DR76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

1298593:TOL RS02745
gene id: 1298593:TOL_RS02745
uniprot id: M5DZU0
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS01440
gene id: 1298593:TOL_RS01440
uniprot id: M5DLQ9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1298593:TOL RS18125
gene id: 1298593:TOL_RS18125
uniprot id: M5DMJ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1298593:TOL RS12470
gene id: 1298593:TOL_RS12470
uniprot id: M5DUA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1298593:TOL RS07580
gene id: 1298593:TOL_RS07580
uniprot id: M5E3A4
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1298593:TOL RS11275
gene id: 1298593:TOL_RS11275
uniprot id: M5DU29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS11615
gene id: 1298593:TOL_RS11615
uniprot id: M5DTF6
names: Subcellular Location Annotation
messages: Cytoplasm

1298593:TOL RS10545
gene id: 1298593:TOL_RS10545
uniprot id: M5E553
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1298593:TOL RS12945
gene id: 1298593:TOL_RS12945
uniprot id: M5E6J1
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

1298593:TOL RS12670
gene id: 1298593:TOL_RS12670
uniprot id: M5DUW8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1298593:TOL RS12515
gene id: 1298593:TOL_RS12515
uniprot id: M5DUT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1298593:TOL RS14490
gene id: 1298593:TOL_RS14490
uniprot id: M5DVT7
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1298593:TOL RS16670
gene id: 1298593:TOL_RS16670
uniprot id: M5DVD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1298593:TOL RS10190
gene id: 1298593:TOL_RS10190
uniprot id: M5DTJ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

1298593:TOL RS16710
gene id: 1298593:TOL_RS16710
uniprot id: M5DW93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1298593:TOL RS11805
gene id: 1298593:TOL_RS11805
uniprot id: M5DUC1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1298593:TOL RS00750
gene id: 1298593:TOL_RS00750
uniprot id: M5DMK0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS14555
gene id: 1298593:TOL_RS14555
uniprot id: M5DVG6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS04300
gene id: 1298593:TOL_RS04300
uniprot id: M5DN13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm

1298593:TOL RS09590
gene id: 1298593:TOL_RS09590
uniprot id: M5E4H5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1298593:TOL RS04205
gene id: 1298593:TOL_RS04205
uniprot id: M5DMZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1298593:TOL RS10195
gene id: 1298593:TOL_RS10195
uniprot id: M5DSP5
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1298593:TOL RS11700
gene id: 1298593:TOL_RS11700
uniprot id: M5DSB2
names: Cofactor
messages: Can also use Mn(2+) ion.

1298593:TOL RS09975
gene id: 1298593:TOL_RS09975
uniprot id: M5E4T1
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS16685
gene id: 1298593:TOL_RS16685
uniprot id: M5DW88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1298593:TOL RS15430
gene id: 1298593:TOL_RS15430
uniprot id: M5E8C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

1298593:TOL RS15715
gene id: 1298593:TOL_RS15715
uniprot id: M5DUU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

1298593:TOL RS10000
gene id: 1298593:TOL_RS10000
uniprot id: M5E4T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1298593:TOL RS13345
gene id: 1298593:TOL_RS13345
uniprot id: M5DUT1
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

1298593:TOL RS03875
gene id: 1298593:TOL_RS03875
uniprot id: M5DPZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1298593:TOL RS05145
gene id: 1298593:TOL_RS05145
uniprot id: M5E1L7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
messages: Monomer.

1298593:TOL RS03515
gene id: 1298593:TOL_RS03515
uniprot id: M5DPU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1298593:TOL RS13740
gene id: 1298593:TOL_RS13740
uniprot id: M5DTL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1298593:TOL RS09050
gene id: 1298593:TOL_RS09050
uniprot id: M5DSV1
names: Similarity
messages: Belongs to the UPF0434 family.

1298593:TOL RS03120
gene id: 1298593:TOL_RS03120
uniprot id: M5DNT3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS13255
gene id: 1298593:TOL_RS13255
uniprot id: M5DV68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1298593:TOL RS16675
gene id: 1298593:TOL_RS16675
uniprot id: M5DWL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1298593:TOL RS14025
gene id: 1298593:TOL_RS14025
uniprot id: M5DUS3
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1298593:TOL RS05360
gene id: 1298593:TOL_RS05360
uniprot id: M5DPZ6
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS17880
gene id: 1298593:TOL_RS17880
uniprot id: M5DW81
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

1298593:TOL RS11000
gene id: 1298593:TOL_RS11000
uniprot id: M5DTY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1298593:TOL RS05840
gene id: 1298593:TOL_RS05840
uniprot id: M5DQG1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS02530
gene id: 1298593:TOL_RS02530
uniprot id: M5DM70
names: Similarity
messages: Belongs to the UPF0178 family.

1298593:TOL RS00165
gene id: 1298593:TOL_RS00165
uniprot id: M5DN26
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1298593:TOL RS13065
gene id: 1298593:TOL_RS13065
uniprot id: M5DUA8
names: Similarity
messages: Belongs to the PhzF family.

1298593:TOL RS15805
gene id: 1298593:TOL_RS15805
uniprot id: M5DVS8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1298593:TOL RS10335
gene id: 1298593:TOL_RS10335
uniprot id: M5E534
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1298593:TOL RS17940
gene id: 1298593:TOL_RS17940
uniprot id: M5DXL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
messages: Cell membrane
messages: Forms a complex with DabA.
messages: Membrane
messages: Part of an energy-coupled inorganic carbon pump.

1298593:TOL RS16280
gene id: 1298593:TOL_RS16280
uniprot id: M5E8P8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS02940
gene id: 1298593:TOL_RS02940
uniprot id: M5DZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1298593:TOL RS17595
gene id: 1298593:TOL_RS17595
uniprot id: M5DXE8
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

1298593:TOL RS11175
gene id: 1298593:TOL_RS11175
uniprot id: M5DU13
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS13015
gene id: 1298593:TOL_RS13015
uniprot id: M5DUA2
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1298593:TOL RS16745
gene id: 1298593:TOL_RS16745
uniprot id: M5E919
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1298593:TOL RS00100
gene id: 1298593:TOL_RS00100
uniprot id: M5DY70
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1298593:TOL RS03445
gene id: 1298593:TOL_RS03445
uniprot id: M5DPS7
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1298593:TOL RS10330
gene id: 1298593:TOL_RS10330
uniprot id: M5DST4
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1298593:TOL RS07625
gene id: 1298593:TOL_RS07625
uniprot id: M5E3B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1298593:TOL RS05850
gene id: 1298593:TOL_RS05850
uniprot id: M5DQ56
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS05325
gene id: 1298593:TOL_RS05325
uniprot id: M5DQ83
names: Cofactor
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group I subfamily.
messages: Binds 1 heme group per subunit.

1298593:TOL RS12620
gene id: 1298593:TOL_RS12620
uniprot id: M5DUV5
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1298593:TOL RS13195
gene id: 1298593:TOL_RS13195
uniprot id: M5E6P0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1298593:TOL RS06120
gene id: 1298593:TOL_RS06120
uniprot id: M5E288
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1298593:TOL RS02665
gene id: 1298593:TOL_RS02665
uniprot id: M5DZS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1298593:TOL RS17930
gene id: 1298593:TOL_RS17930
uniprot id: M5DW89
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1298593:TOL RS16565
gene id: 1298593:TOL_RS16565
uniprot id: M5E8W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1298593:TOL RS05010
gene id: 1298593:TOL_RS05010
uniprot id: M5DPY3
names: Function
names: Similarity
messages: Belongs to the peptidase M16 family.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.

1298593:TOL RS08045
gene id: 1298593:TOL_RS08045
uniprot id: M5E3M0
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1298593:TOL RS08680
gene id: 1298593:TOL_RS08680
uniprot id: M5DQL4
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

1298593:TOL RS04680
gene id: 1298593:TOL_RS04680
uniprot id: M5DPR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1298593:TOL RS18280
gene id: 1298593:TOL_RS18280
uniprot id: M5DS53
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS10045
gene id: 1298593:TOL_RS10045
uniprot id: M5DSK3
names: Similarity
messages: Belongs to the YkuD family.

1298593:TOL RS14370
gene id: 1298593:TOL_RS14370
uniprot id: M5DUY9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1298593:TOL RS09750
gene id: 1298593:TOL_RS09750
uniprot id: M5DT96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

1298593:TOL RS14975
gene id: 1298593:TOL_RS14975
uniprot id: M5E812
names: Subcellular Location Annotation
messages: Cytoplasm

1298593:TOL RS03355
gene id: 1298593:TOL_RS03355
uniprot id: M5E062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

1298593:TOL RS14940
gene id: 1298593:TOL_RS14940
uniprot id: M5DW40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.

1298593:TOL RS01610
gene id: 1298593:TOL_RS01610
uniprot id: M5DZ18
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS06130
gene id: 1298593:TOL_RS06130
uniprot id: M5DQK6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1298593:TOL RS01195
gene id: 1298593:TOL_RS01195
uniprot id: M5DLM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell outer membrane
messages: Homodimer.
messages: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.

1298593:TOL RS14600
gene id: 1298593:TOL_RS14600
uniprot id: M5DU49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

1298593:TOL RS17570
gene id: 1298593:TOL_RS17570
uniprot id: M5DX59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

1298593:TOL RS16725
gene id: 1298593:TOL_RS16725
uniprot id: M5DWM3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS05935
gene id: 1298593:TOL_RS05935
uniprot id: M5DNX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS13050
gene id: 1298593:TOL_RS13050
uniprot id: M5DT81
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

1298593:TOL RS03705
gene id: 1298593:TOL_RS03705
uniprot id: M5DP48
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS13265
gene id: 1298593:TOL_RS13265
uniprot id: M5E6Q5
names: Similarity
messages: Belongs to the HsdR family.

1298593:TOL RS14735
gene id: 1298593:TOL_RS14735
uniprot id: M5DV75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1298593:TOL RS17650
gene id: 1298593:TOL_RS17650
uniprot id: M5DWV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

1298593:TOL RS16195
gene id: 1298593:TOL_RS16195
uniprot id: M5DWB3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1298593:TOL RS00715
gene id: 1298593:TOL_RS00715
uniprot id: M5DNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1298593:TOL RS17725
gene id: 1298593:TOL_RS17725
uniprot id: M5DWW6
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

1298593:TOL RS13805
gene id: 1298593:TOL_RS13805
uniprot id: M5DUM9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1298593:TOL RS10375
gene id: 1298593:TOL_RS10375
uniprot id: M5DTN6
names: Similarity
messages: Belongs to the peptidase S41A family.

1298593:TOL RS05915
gene id: 1298593:TOL_RS05915
uniprot id: M5DQH4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1298593:TOL RS12495
gene id: 1298593:TOL_RS12495
uniprot id: M5DUS2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1298593:TOL RS09465
gene id: 1298593:TOL_RS09465
uniprot id: M5E4E3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS10630
gene id: 1298593:TOL_RS10630
uniprot id: M5DT67
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1298593:TOL RS07405
gene id: 1298593:TOL_RS07405
uniprot id: M5DS32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1298593:TOL RS15345
gene id: 1298593:TOL_RS15345
uniprot id: M5DWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS09645
gene id: 1298593:TOL_RS09645
uniprot id: M5DSL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

1298593:TOL RS06520
gene id: 1298593:TOL_RS06520
uniprot id: M5DRI4
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS17235
gene id: 1298593:TOL_RS17235
uniprot id: M5DX77
names: Similarity
messages: Belongs to the P(II) protein family.

1298593:TOL RS12010
gene id: 1298593:TOL_RS12010
uniprot id: M5DSI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

1298593:TOL RS17430
gene id: 1298593:TOL_RS17430
uniprot id: M5DXB1
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1298593:TOL RS08195
gene id: 1298593:TOL_RS08195
uniprot id: M5DSH9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS14885
gene id: 1298593:TOL_RS14885
uniprot id: M5DVP5
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1298593:TOL RS11330
gene id: 1298593:TOL_RS11330
uniprot id: M5DTA1
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1298593:TOL RS03475
gene id: 1298593:TOL_RS03475
uniprot id: M5E082
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1298593:TOL RS08980
gene id: 1298593:TOL_RS08980
uniprot id: M5DST7
names: Subcellular Location Annotation
messages: Secreted

1298593:TOL RS07930
gene id: 1298593:TOL_RS07930
uniprot id: M5DRM8
names: Similarity
messages: Belongs to the fabD family.

1298593:TOL RS15485
gene id: 1298593:TOL_RS15485
uniprot id: M5DUR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1298593:TOL RS01005
gene id: 1298593:TOL_RS01005
uniprot id: M5DLJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1298593:TOL RS17505
gene id: 1298593:TOL_RS17505
uniprot id: M5DWR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1298593:TOL RS14670
gene id: 1298593:TOL_RS14670
uniprot id: M5E7P5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS16635
gene id: 1298593:TOL_RS16635
uniprot id: M5DW76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1298593:TOL RS07615
gene id: 1298593:TOL_RS07615
uniprot id: M5DS77
names: Similarity
messages: Belongs to the peptidase S16 family.

1298593:TOL RS14460
gene id: 1298593:TOL_RS14460
uniprot id: M5DVE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

1298593:TOL RS00580
gene id: 1298593:TOL_RS00580
uniprot id: M5DYI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1298593:TOL RS10765
gene id: 1298593:TOL_RS10765
uniprot id: M5DRU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1298593:TOL RS08940
gene id: 1298593:TOL_RS08940
uniprot id: M5DST3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1298593:TOL RS15005
gene id: 1298593:TOL_RS15005
uniprot id: M5DUF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1298593:TOL RS07355
gene id: 1298593:TOL_RS07355
uniprot id: M5DS22
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS17890
gene id: 1298593:TOL_RS17890
uniprot id: M5DXK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

1298593:TOL RS00630
gene id: 1298593:TOL_RS00630
uniprot id: M5DYJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

1298593:TOL RS00415
gene id: 1298593:TOL_RS00415
uniprot id: M5DYF1
names: Similarity
messages: Belongs to the pseudomonas-type ThrB family.

1298593:TOL RS14265
gene id: 1298593:TOL_RS14265
uniprot id: M5DVP1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

1298593:TOL RS12145
gene id: 1298593:TOL_RS12145
uniprot id: M5DUI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cytoplasm

1298593:TOL RS12875
gene id: 1298593:TOL_RS12875
uniprot id: M5DT54
names: Similarity
messages: Belongs to the GST superfamily.

1298593:TOL RS14890
gene id: 1298593:TOL_RS14890
uniprot id: M5DW30
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1298593:TOL RS06275
gene id: 1298593:TOL_RS06275
uniprot id: M5DP52
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS17190
gene id: 1298593:TOL_RS17190
uniprot id: M5DX67
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1298593:TOL RS06885
gene id: 1298593:TOL_RS06885
uniprot id: M5DQS2
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1298593:TOL RS06730
gene id: 1298593:TOL_RS06730
uniprot id: M5DQV3
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1298593:TOL RS01305
gene id: 1298593:TOL_RS01305
uniprot id: M5DMT4
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

1298593:TOL RS01130
gene id: 1298593:TOL_RS01130
uniprot id: M5DMU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1298593:TOL RS07840
gene id: 1298593:TOL_RS07840
uniprot id: M5DRE7
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1298593:TOL RS09215
gene id: 1298593:TOL_RS09215
uniprot id: M5E493
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1298593:TOL RS09105
gene id: 1298593:TOL_RS09105
uniprot id: M5DS04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and 5'-3' DNA helicase.

1298593:TOL RS03740
gene id: 1298593:TOL_RS03740
uniprot id: M5DP14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1298593:TOL RS15450
gene id: 1298593:TOL_RS15450
uniprot id: M5DVN2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1298593:TOL RS02830
gene id: 1298593:TOL_RS02830
uniprot id: M5DNL1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1298593:TOL RS16525
gene id: 1298593:TOL_RS16525
uniprot id: M5E8V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1298593:TOL RS11820
gene id: 1298593:TOL_RS11820
uniprot id: M5DSE6
names: Similarity
messages: Belongs to the pirin family.

1298593:TOL RS15160
gene id: 1298593:TOL_RS15160
uniprot id: M5DVJ3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1298593:TOL RS08655
gene id: 1298593:TOL_RS08655
uniprot id: M5DQK8
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1298593:TOL RS03030
gene id: 1298593:TOL_RS03030
uniprot id: M5DNQ0
names: Similarity
messages: Belongs to the MotB family.

1298593:TOL RS11225
gene id: 1298593:TOL_RS11225
uniprot id: M5DU21
names: Similarity
messages: Belongs to the ArsC family.

1298593:TOL RS00725
gene id: 1298593:TOL_RS00725
uniprot id: M5DYK7
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

1298593:TOL RS18445
gene id: 1298593:TOL_RS18445
uniprot id: M5DTT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1298593:TOL RS01960
gene id: 1298593:TOL_RS01960
uniprot id: M5DN59
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

1298593:TOL RS14525
gene id: 1298593:TOL_RS14525
uniprot id: M5E7J8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Monomer.

1298593:TOL RS14310
gene id: 1298593:TOL_RS14310
uniprot id: M5DVB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

1298593:TOL RS18010
gene id: 1298593:TOL_RS18010
uniprot id: M5DXL9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1298593:TOL RS16715
gene id: 1298593:TOL_RS16715
uniprot id: M5E909
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1298593:TOL RS11765
gene id: 1298593:TOL_RS11765
uniprot id: M5E5T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1298593:TOL RS11115
gene id: 1298593:TOL_RS11115
uniprot id: M5DS05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

1298593:TOL RS00130
gene id: 1298593:TOL_RS00130
uniprot id: M5DL49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1298593:TOL RS16575
gene id: 1298593:TOL_RS16575
uniprot id: M5DWJ3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1298593:TOL RS14785
gene id: 1298593:TOL_RS14785
uniprot id: M5DV88
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS10710
gene id: 1298593:TOL_RS10710
uniprot id: M5DTT2
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1298593:TOL RS12685
gene id: 1298593:TOL_RS12685
uniprot id: M5DT03
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1298593:TOL RS15095
gene id: 1298593:TOL_RS15095
uniprot id: M5E845
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1298593:TOL RS00585
gene id: 1298593:TOL_RS00585
uniprot id: M5DLD5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1298593:TOL RS07365
gene id: 1298593:TOL_RS07365
uniprot id: M5E330
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1298593:TOL RS10580
gene id: 1298593:TOL_RS10580
uniprot id: M5DT59
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1298593:TOL RS15535
gene id: 1298593:TOL_RS15535
uniprot id: M5DUS1
names: Similarity
messages: Belongs to the MotB family.

1298593:TOL RS11445
gene id: 1298593:TOL_RS11445
uniprot id: M5DTC4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS02890
gene id: 1298593:TOL_RS02890
uniprot id: M5DZX9
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

1298593:TOL RS16700
gene id: 1298593:TOL_RS16700
uniprot id: M5DWL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1298593:TOL RS14575
gene id: 1298593:TOL_RS14575
uniprot id: M5DU43
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

1298593:TOL RS13330
gene id: 1298593:TOL_RS13330
uniprot id: M5DUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1298593:TOL RS03235
gene id: 1298593:TOL_RS03235
uniprot id: M5DMI9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS04070
gene id: 1298593:TOL_RS04070
uniprot id: M5DPC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1298593:TOL RS14545
gene id: 1298593:TOL_RS14545
uniprot id: M5E7K8
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

1298593:TOL RS13140
gene id: 1298593:TOL_RS13140
uniprot id: M5DUB8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1298593:TOL RS03125
gene id: 1298593:TOL_RS03125
uniprot id: M5DPN0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS16605
gene id: 1298593:TOL_RS16605
uniprot id: M5DWW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1298593:TOL RS03635
gene id: 1298593:TOL_RS03635
uniprot id: M5DP34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

1298593:TOL RS11770
gene id: 1298593:TOL_RS11770
uniprot id: M5DSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1298593:TOL RS09800
gene id: 1298593:TOL_RS09800
uniprot id: M5DTA8
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS15955
gene id: 1298593:TOL_RS15955
uniprot id: M5E8J7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1298593:TOL RS19200
gene id: 1298593:TOL_RS19200
uniprot id: M5DMS4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1298593:TOL RS11230
gene id: 1298593:TOL_RS11230
uniprot id: M5DT82
names: Similarity
messages: Belongs to the WrbA family.

1298593:TOL RS14485
gene id: 1298593:TOL_RS14485
uniprot id: M5DVF0
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1298593:TOL RS09505
gene id: 1298593:TOL_RS09505
uniprot id: M5DT40
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS15580
gene id: 1298593:TOL_RS15580
uniprot id: M5E8E2
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS13550
gene id: 1298593:TOL_RS13550
uniprot id: M5DTH4
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS05185
gene id: 1298593:TOL_RS05185
uniprot id: M5DQU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1298593:TOL RS03505
gene id: 1298593:TOL_RS03505
uniprot id: M5DMN1
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1298593:TOL RS09985
gene id: 1298593:TOL_RS09985
uniprot id: M5DSU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1298593:TOL RS03595
gene id: 1298593:TOL_RS03595
uniprot id: M5DNZ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS17230
gene id: 1298593:TOL_RS17230
uniprot id: M5DWX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

1298593:TOL RS00090
gene id: 1298593:TOL_RS00090
uniprot id: M5DN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1298593:TOL RS11755
gene id: 1298593:TOL_RS11755
uniprot id: M5DUB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1298593:TOL RS13410
gene id: 1298593:TOL_RS13410
uniprot id: M5DTE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1298593:TOL RS06755
gene id: 1298593:TOL_RS06755
uniprot id: M5DQV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1298593:TOL RS02875
gene id: 1298593:TOL_RS02875
uniprot id: M5DMD3
names: Similarity
messages: Belongs to the UPF0229 family.

1298593:TOL RS13715
gene id: 1298593:TOL_RS13715
uniprot id: M5DTK7
names: Similarity
messages: Belongs to the oxoprolinase family.

1298593:TOL RS13115
gene id: 1298593:TOL_RS13115
uniprot id: M5E6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1298593:TOL RS11545
gene id: 1298593:TOL_RS11545
uniprot id: M5E5P3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1298593:TOL RS06365
gene id: 1298593:TOL_RS06365
uniprot id: M5DRF0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS03790
gene id: 1298593:TOL_RS03790
uniprot id: M5DP21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

1298593:TOL RS18000
gene id: 1298593:TOL_RS18000
uniprot id: M5DWA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1298593:TOL RS08440
gene id: 1298593:TOL_RS08440
uniprot id: M5DRW8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1298593:TOL RS10895
gene id: 1298593:TOL_RS10895
uniprot id: M5DTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1298593:TOL RS17995
gene id: 1298593:TOL_RS17995
uniprot id: M5EA28
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS15370
gene id: 1298593:TOL_RS15370
uniprot id: M5DWE4
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS17050
gene id: 1298593:TOL_RS17050
uniprot id: M5DWG5
names: Similarity
messages: Belongs to the UPF0235 family.

1298593:TOL RS08665
gene id: 1298593:TOL_RS08665
uniprot id: M5DSP3
names: Subcellular Location Annotation
messages: Cytoplasm

1298593:TOL RS01880
gene id: 1298593:TOL_RS01880
uniprot id: M5DZ84
names: Similarity
messages: Belongs to the VgrG protein family.

1298593:TOL RS11160
gene id: 1298593:TOL_RS11160
uniprot id: M5E5G3
names: Subcellular Location Annotation
messages: Cytoplasm

1298593:TOL RS16260
gene id: 1298593:TOL_RS16260
uniprot id: M5DV42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1298593:TOL RS12980
gene id: 1298593:TOL_RS12980
uniprot id: M5DUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

1298593:TOL RS15750
gene id: 1298593:TOL_RS15750
uniprot id: M5DWJ4
names: Similarity
messages: Belongs to the SufE family.

1298593:TOL RS11035
gene id: 1298593:TOL_RS11035
uniprot id: M5E5D8
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1298593:TOL RS11190
gene id: 1298593:TOL_RS11190
uniprot id: M5DS17
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS04490
gene id: 1298593:TOL_RS04490
uniprot id: M5DN49
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1298593:TOL RS08925
gene id: 1298593:TOL_RS08925
uniprot id: M5E430
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1298593:TOL RS05195
gene id: 1298593:TOL_RS05195
uniprot id: M5E1N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1298593:TOL RS08685
gene id: 1298593:TOL_RS08685
uniprot id: M5DS09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS02775
gene id: 1298593:TOL_RS02775
uniprot id: M5DNK0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1298593:TOL RS08890
gene id: 1298593:TOL_RS08890
uniprot id: M5DRW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1298593:TOL RS01720
gene id: 1298593:TOL_RS01720
uniprot id: M5DMZ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1298593:TOL RS14250
gene id: 1298593:TOL_RS14250
uniprot id: M5E7C2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS14610
gene id: 1298593:TOL_RS14610
uniprot id: M5DVW2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1298593:TOL RS17070
gene id: 1298593:TOL_RS17070
uniprot id: M5DX44
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1298593:TOL RS05520
gene id: 1298593:TOL_RS05520
uniprot id: M5DR25
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS17515
gene id: 1298593:TOL_RS17515
uniprot id: M5E9R8
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS13650
gene id: 1298593:TOL_RS13650
uniprot id: M5DUY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS10785
gene id: 1298593:TOL_RS10785
uniprot id: M5E591
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1298593:TOL RS04305
gene id: 1298593:TOL_RS04305
uniprot id: M5DPH2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1298593:TOL RS11610
gene id: 1298593:TOL_RS11610
uniprot id: M5DU81
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1298593:TOL RS13185
gene id: 1298593:TOL_RS13185
uniprot id: M5DV58
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1298593:TOL RS01210
gene id: 1298593:TOL_RS01210
uniprot id: M5DMS0
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS14475
gene id: 1298593:TOL_RS14475
uniprot id: M5E7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1298593:TOL RS17365
gene id: 1298593:TOL_RS17365
uniprot id: M5E9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS15030
gene id: 1298593:TOL_RS15030
uniprot id: M5DUG0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1298593:TOL RS15025
gene id: 1298593:TOL_RS15025
uniprot id: M5E824
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1298593:TOL RS13800
gene id: 1298593:TOL_RS13800
uniprot id: M5DVF3
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1298593:TOL RS13930
gene id: 1298593:TOL_RS13930
uniprot id: M5E753
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

1298593:TOL RS00190
gene id: 1298593:TOL_RS00190
uniprot id: M5DN29
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1298593:TOL RS10270
gene id: 1298593:TOL_RS10270
uniprot id: M5DSS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1298593:TOL RS04440
gene id: 1298593:TOL_RS04440
uniprot id: M5DN41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1298593:TOL RS15035
gene id: 1298593:TOL_RS15035
uniprot id: M5DVS9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1298593:TOL RS05190
gene id: 1298593:TOL_RS05190
uniprot id: M5DPU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1298593:TOL RS11080
gene id: 1298593:TOL_RS11080
uniprot id: M5DT48
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1298593:TOL RS09695
gene id: 1298593:TOL_RS09695
uniprot id: M5DSM3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

1298593:TOL RS14650
gene id: 1298593:TOL_RS14650
uniprot id: M5DU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

1298593:TOL RS14950
gene id: 1298593:TOL_RS14950
uniprot id: M5E806
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

1298593:TOL RS00160
gene id: 1298593:TOL_RS00160
uniprot id: M5DMD8
names: Function
names: Similarity
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.

1298593:TOL RS08660
gene id: 1298593:TOL_RS08660
uniprot id: M5DS03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1298593:TOL RS17835
gene id: 1298593:TOL_RS17835
uniprot id: M5DXC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1298593:TOL RS11010
gene id: 1298593:TOL_RS11010
uniprot id: M5E5D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1298593:TOL RS15425
gene id: 1298593:TOL_RS15425
uniprot id: M5DVM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1298593:TOL RS17375
gene id: 1298593:TOL_RS17375
uniprot id: M5DX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS05845
gene id: 1298593:TOL_RS05845
uniprot id: M5DR70
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1298593:TOL RS14640
gene id: 1298593:TOL_RS14640
uniprot id: M5DV53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1298593:TOL RS08100
gene id: 1298593:TOL_RS08100
uniprot id: M5DRQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1298593:TOL RS17205
gene id: 1298593:TOL_RS17205
uniprot id: M5DVR7
names: Similarity
messages: Belongs to the thioredoxin family.

1298593:TOL RS12385
gene id: 1298593:TOL_RS12385
uniprot id: M5DTX2
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1298593:TOL RS01110
gene id: 1298593:TOL_RS01110
uniprot id: M5DNF9
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS12105
gene id: 1298593:TOL_RS12105
uniprot id: M5E608
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1298593:TOL RS07785
gene id: 1298593:TOL_RS07785
uniprot id: M5DSB8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS15605
gene id: 1298593:TOL_RS15605
uniprot id: M5E8E4
names: Similarity
messages: Belongs to the glutamate synthase family.

1298593:TOL RS13915
gene id: 1298593:TOL_RS13915
uniprot id: M5DV36
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1298593:TOL RS07920
gene id: 1298593:TOL_RS07920
uniprot id: M5E3K0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1298593:TOL RS08860
gene id: 1298593:TOL_RS08860
uniprot id: M5DSS1
names: Similarity
messages: Belongs to the peptidase S49 family.

1298593:TOL RS04005
gene id: 1298593:TOL_RS04005
uniprot id: M5E0L7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1298593:TOL RS14030
gene id: 1298593:TOL_RS14030
uniprot id: M5E773
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1298593:TOL RS04995
gene id: 1298593:TOL_RS04995
uniprot id: M5DPQ3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS17320
gene id: 1298593:TOL_RS17320
uniprot id: M5E9K2
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS01120
gene id: 1298593:TOL_RS01120
uniprot id: M5DYS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1298593:TOL RS13595
gene id: 1298593:TOL_RS13595
uniprot id: M5E6X7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS15545
gene id: 1298593:TOL_RS15545
uniprot id: M5DWG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1298593:TOL RS01140
gene id: 1298593:TOL_RS01140
uniprot id: M5DMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1298593:TOL RS04355
gene id: 1298593:TOL_RS04355
uniprot id: M5DQ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1298593:TOL RS05155
gene id: 1298593:TOL_RS05155
uniprot id: M5DQ19
names: Similarity
messages: Belongs to the asparaginase 1 family.

1298593:TOL RS08190
gene id: 1298593:TOL_RS08190
uniprot id: M5DRS6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1298593:TOL RS06265
gene id: 1298593:TOL_RS06265
uniprot id: M5DQD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AFG1 ATPase family. ZapE subfamily.
messages: Cytoplasm
messages: Interacts with FtsZ.
messages: Reduces the stability of FtsZ polymers in the presence of ATP.

1298593:TOL RS04410
gene id: 1298593:TOL_RS04410
uniprot id: M5E0X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1298593:TOL RS08030
gene id: 1298593:TOL_RS08030
uniprot id: M5DRP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

1298593:TOL RS04940
gene id: 1298593:TOL_RS04940
uniprot id: M5DQN4
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1298593:TOL RS08155
gene id: 1298593:TOL_RS08155
uniprot id: M5DSH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1298593:TOL RS14445
gene id: 1298593:TOL_RS14445
uniprot id: M5DV03
names: Similarity
messages: Belongs to the LEA type 2 family.

1298593:TOL RS09035
gene id: 1298593:TOL_RS09035
uniprot id: M5E455
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1298593:TOL RS13900
gene id: 1298593:TOL_RS13900
uniprot id: M5DUP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1298593:TOL RS07430
gene id: 1298593:TOL_RS07430
uniprot id: M5DS37
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS11860
gene id: 1298593:TOL_RS11860
uniprot id: M5DSF3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS12140
gene id: 1298593:TOL_RS12140
uniprot id: M5DU15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS14020
gene id: 1298593:TOL_RS14020
uniprot id: M5DVJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1298593:TOL RS12460
gene id: 1298593:TOL_RS12460
uniprot id: M5E692
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1298593:TOL RS02950
gene id: 1298593:TOL_RS02950
uniprot id: M5DNQ3
names: Similarity
messages: Belongs to the GSP N family.

1298593:TOL RS10610
gene id: 1298593:TOL_RS10610
uniprot id: M5DTR7
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS08460
gene id: 1298593:TOL_RS08460
uniprot id: M5DQH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP L family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

1298593:TOL RS11120
gene id: 1298593:TOL_RS11120
uniprot id: M5DTF7
names: Similarity
messages: Belongs to the YciI family.

1298593:TOL RS14905
gene id: 1298593:TOL_RS14905
uniprot id: M5DUD3
names: Similarity
messages: Belongs to the BolA/IbaG family.

1298593:TOL RS04525
gene id: 1298593:TOL_RS04525
uniprot id: M5E109
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

1298593:TOL RS14980
gene id: 1298593:TOL_RS14980
uniprot id: M5DUF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1298593:TOL RS01260
gene id: 1298593:TOL_RS01260
uniprot id: M5DMS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS13830
gene id: 1298593:TOL_RS13830
uniprot id: M5E731
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS10910
gene id: 1298593:TOL_RS10910
uniprot id: M5DRX4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS09405
gene id: 1298593:TOL_RS09405
uniprot id: M5E4C8
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1298593:TOL RS10410
gene id: 1298593:TOL_RS10410
uniprot id: M5E541
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1298593:TOL RS11145
gene id: 1298593:TOL_RS11145
uniprot id: M5DTG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

1298593:TOL RS05460
gene id: 1298593:TOL_RS05460
uniprot id: M5E1Y2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1298593:TOL RS03240
gene id: 1298593:TOL_RS03240
uniprot id: M5DNV4
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

1298593:TOL RS13100
gene id: 1298593:TOL_RS13100
uniprot id: M5DUN9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1298593:TOL RS09805
gene id: 1298593:TOL_RS09805
uniprot id: M5DSE3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS07375
gene id: 1298593:TOL_RS07375
uniprot id: M5DR94
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS12610
gene id: 1298593:TOL_RS12610
uniprot id: M5DSY5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1298593:TOL RS01445
gene id: 1298593:TOL_RS01445
uniprot id: M5DMY9
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1298593:TOL RS08020
gene id: 1298593:TOL_RS08020
uniprot id: M5E3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS05790
gene id: 1298593:TOL_RS05790
uniprot id: M5DQF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

1298593:TOL RS11100
gene id: 1298593:TOL_RS11100
uniprot id: M5DU03
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1298593:TOL RS17260
gene id: 1298593:TOL_RS17260
uniprot id: M5DX81
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS04750
gene id: 1298593:TOL_RS04750
uniprot id: M5DN98
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1298593:TOL RS09685
gene id: 1298593:TOL_RS09685
uniprot id: M5E4J8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

1298593:TOL RS04530
gene id: 1298593:TOL_RS04530
uniprot id: M5DN56
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Cell membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1298593:TOL RS02630
gene id: 1298593:TOL_RS02630
uniprot id: M5DNG4
names: Function
names: Subcellular Location Annotation
messages: Involved in mercury resistance. Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT.
messages: Periplasm

1298593:TOL RS04435
gene id: 1298593:TOL_RS04435
uniprot id: M5E0X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

1298593:TOL RS13325
gene id: 1298593:TOL_RS13325
uniprot id: M5DV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1298593:TOL RS07410
gene id: 1298593:TOL_RS07410
uniprot id: M5DR38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1298593:TOL RS17175
gene id: 1298593:TOL_RS17175
uniprot id: M5E9G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1298593:TOL RS01715
gene id: 1298593:TOL_RS01715
uniprot id: M5DNR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1298593:TOL RS18005
gene id: 1298593:TOL_RS18005
uniprot id: M5DXF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1298593:TOL RS15935
gene id: 1298593:TOL_RS15935
uniprot id: M5DUY2
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-II family.

1298593:TOL RS00440
gene id: 1298593:TOL_RS00440
uniprot id: M5DYG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane
messages: Required for nicotinamide riboside transport across the inner membrane.

1298593:TOL RS06170
gene id: 1298593:TOL_RS06170
uniprot id: M5E295
names: Similarity
messages: Belongs to the fructosamine kinase family.

1298593:TOL RS01940
gene id: 1298593:TOL_RS01940
uniprot id: M5DNW7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1298593:TOL RS14170
gene id: 1298593:TOL_RS14170
uniprot id: M5E7A5
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

1298593:TOL RS15455
gene id: 1298593:TOL_RS15455
uniprot id: M5E8C5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1298593:TOL RS09155
gene id: 1298593:TOL_RS09155
uniprot id: M5E481
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1298593:TOL RS08630
gene id: 1298593:TOL_RS08630
uniprot id: M5DQK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

1298593:TOL RS08015
gene id: 1298593:TOL_RS08015
uniprot id: M5DRH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1298593:TOL RS04325
gene id: 1298593:TOL_RS04325
uniprot id: M5DPH7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS12370
gene id: 1298593:TOL_RS12370
uniprot id: M5DSR8
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS01500
gene id: 1298593:TOL_RS01500
uniprot id: M5DNM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1298593:TOL RS17120
gene id: 1298593:TOL_RS17120
uniprot id: M5DX55
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1298593:TOL RS15445
gene id: 1298593:TOL_RS15445
uniprot id: M5DWF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1298593:TOL RS16735
gene id: 1298593:TOL_RS16735
uniprot id: M5DWY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1298593:TOL RS10390
gene id: 1298593:TOL_RS10390
uniprot id: M5DRN7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS10055
gene id: 1298593:TOL_RS10055
uniprot id: M5DRF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1298593:TOL RS11420
gene id: 1298593:TOL_RS11420
uniprot id: M5DTB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
messages: Membrane

1298593:TOL RS13520
gene id: 1298593:TOL_RS13520
uniprot id: M5E6V9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS02130
gene id: 1298593:TOL_RS02130
uniprot id: M5DM04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1298593:TOL RS15910
gene id: 1298593:TOL_RS15910
uniprot id: M5E8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1298593:TOL RS00095
gene id: 1298593:TOL_RS00095
uniprot id: M5DM89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1298593:TOL RS14845
gene id: 1298593:TOL_RS14845
uniprot id: M5DW20
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS06745
gene id: 1298593:TOL_RS06745
uniprot id: M5E2K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1298593:TOL RS15575
gene id: 1298593:TOL_RS15575
uniprot id: M5DVQ0
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS05490
gene id: 1298593:TOL_RS05490
uniprot id: M5DQB5
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS07640
gene id: 1298593:TOL_RS07640
uniprot id: M5DS81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

1298593:TOL RS17040
gene id: 1298593:TOL_RS17040
uniprot id: M5DWT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1298593:TOL RS03735
gene id: 1298593:TOL_RS03735
uniprot id: M5DPX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1298593:TOL RS12500
gene id: 1298593:TOL_RS12500
uniprot id: M5E6A2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1298593:TOL RS06915
gene id: 1298593:TOL_RS06915
uniprot id: M5E2P8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS16385
gene id: 1298593:TOL_RS16385
uniprot id: M5DV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1298593:TOL RS05285
gene id: 1298593:TOL_RS05285
uniprot id: M5DPX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1298593:TOL RS03070
gene id: 1298593:TOL_RS03070
uniprot id: M5DNS3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1298593:TOL RS05075
gene id: 1298593:TOL_RS05075
uniprot id: M5DNF7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1298593:TOL RS06865
gene id: 1298593:TOL_RS06865
uniprot id: M5DQR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS17195
gene id: 1298593:TOL_RS17195
uniprot id: M5DWJ8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1298593:TOL RS11795
gene id: 1298593:TOL_RS11795
uniprot id: M5DSD9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS04950
gene id: 1298593:TOL_RS04950
uniprot id: M5E1E5
names: Similarity
messages: Belongs to the RecJ family.

1298593:TOL RS17170
gene id: 1298593:TOL_RS17170
uniprot id: M5DWJ2
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1298593:TOL RS13005
gene id: 1298593:TOL_RS13005
uniprot id: M5DUM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

1298593:TOL RS16610
gene id: 1298593:TOL_RS16610
uniprot id: M5DW70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1298593:TOL RS14305
gene id: 1298593:TOL_RS14305
uniprot id: M5DTX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

1298593:TOL RS13220
gene id: 1298593:TOL_RS13220
uniprot id: M5DTB0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1298593:TOL RS12200
gene id: 1298593:TOL_RS12200
uniprot id: M5DUJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1298593:TOL RS10880
gene id: 1298593:TOL_RS10880
uniprot id: M5E5B0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1298593:TOL RS07415
gene id: 1298593:TOL_RS07415
uniprot id: M5E347
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1298593:TOL RS06965
gene id: 1298593:TOL_RS06965
uniprot id: M5DPK5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1298593:TOL RS06355
gene id: 1298593:TOL_RS06355
uniprot id: M5DP67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

1298593:TOL RS06880
gene id: 1298593:TOL_RS06880
uniprot id: M5DRQ6
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1298593:TOL RS07725
gene id: 1298593:TOL_RS07725
uniprot id: M5E3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1298593:TOL RS05595
gene id: 1298593:TOL_RS05595
uniprot id: M5DQC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

1298593:TOL RS00730
gene id: 1298593:TOL_RS00730
uniprot id: M5DLF6
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

1298593:TOL RS10865
gene id: 1298593:TOL_RS10865
uniprot id: M5DTB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1298593:TOL RS10080
gene id: 1298593:TOL_RS10080
uniprot id: M5DRG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1298593:TOL RS12605
gene id: 1298593:TOL_RS12605
uniprot id: M5E6C0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1298593:TOL RS09995
gene id: 1298593:TOL_RS09995
uniprot id: M5DSJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1298593:TOL RS03965
gene id: 1298593:TOL_RS03965
uniprot id: M5DMV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1298593:TOL RS17840
gene id: 1298593:TOL_RS17840
uniprot id: M5DXJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1298593:TOL RS03710
gene id: 1298593:TOL_RS03710
uniprot id: M5DPW9
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1298593:TOL RS09880
gene id: 1298593:TOL_RS09880
uniprot id: M5E4Q0
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

1298593:TOL RS11125
gene id: 1298593:TOL_RS11125
uniprot id: M5DU05
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS15115
gene id: 1298593:TOL_RS15115
uniprot id: M5DVG7
names: Function
names: Subunit
messages: Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein.
messages: Monomer in both c-di-GMP-bound and free forms.

1298593:TOL RS04670
gene id: 1298593:TOL_RS04670
uniprot id: M5E152
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1298593:TOL RS03800
gene id: 1298593:TOL_RS03800
uniprot id: M5DMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

1298593:TOL RS12390
gene id: 1298593:TOL_RS12390
uniprot id: M5E678
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS08605
gene id: 1298593:TOL_RS08605
uniprot id: M5DQK0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS10105
gene id: 1298593:TOL_RS10105
uniprot id: M5DRG5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

1298593:TOL RS09790
gene id: 1298593:TOL_RS09790
uniprot id: M5DR96
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1298593:TOL RS04240
gene id: 1298593:TOL_RS04240
uniprot id: M5DQ57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1298593:TOL RS17080
gene id: 1298593:TOL_RS17080
uniprot id: M5E9D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1298593:TOL RS00140
gene id: 1298593:TOL_RS00140
uniprot id: M5DN23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1298593:TOL RS13770
gene id: 1298593:TOL_RS13770
uniprot id: M5DV06
names: Similarity
messages: Belongs to the GARS family.

1298593:TOL RS06985
gene id: 1298593:TOL_RS06985
uniprot id: M5E2R6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1298593:TOL RS17575
gene id: 1298593:TOL_RS17575
uniprot id: M5DXE2
names: Similarity
messages: Belongs to the Rsd/AlgQ family.

1298593:TOL RS01430
gene id: 1298593:TOL_RS01430
uniprot id: M5DMV3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1298593:TOL RS01725
gene id: 1298593:TOL_RS01725
uniprot id: M5DZ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1298593:TOL RS08075
gene id: 1298593:TOL_RS08075
uniprot id: M5DRQ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1298593:TOL RS06350
gene id: 1298593:TOL_RS06350
uniprot id: M5E2C6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1298593:TOL RS10415
gene id: 1298593:TOL_RS10415
uniprot id: M5DRP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

1298593:TOL RS12815
gene id: 1298593:TOL_RS12815
uniprot id: M5DU75
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1298593:TOL RS02035
gene id: 1298593:TOL_RS02035
uniprot id: M5DNZ3
names: Similarity
messages: Belongs to the RelE toxin family.

1298593:TOL RS01745
gene id: 1298593:TOL_RS01745
uniprot id: M5DNS1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS14455
gene id: 1298593:TOL_RS14455
uniprot id: M5DU12
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1298593:TOL RS16645
gene id: 1298593:TOL_RS16645
uniprot id: M5DVD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1298593:TOL RS13815
gene id: 1298593:TOL_RS13815
uniprot id: M5DV16
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS02815
gene id: 1298593:TOL_RS02815
uniprot id: M5DNK3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1298593:TOL RS13980
gene id: 1298593:TOL_RS13980
uniprot id: M5E763
names: Similarity
messages: Belongs to the UPF0225 family.

1298593:TOL RS04505
gene id: 1298593:TOL_RS04505
uniprot id: M5E102
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1298593:TOL RS15615
gene id: 1298593:TOL_RS15615
uniprot id: M5DW32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

1298593:TOL RS15845
gene id: 1298593:TOL_RS15845
uniprot id: M5DW61
names: Similarity
messages: Belongs to the allantoicase family.

1298593:TOL RS04575
gene id: 1298593:TOL_RS04575
uniprot id: M5DN65
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1298593:TOL RS11790
gene id: 1298593:TOL_RS11790
uniprot id: M5E5U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1298593:TOL RS12600
gene id: 1298593:TOL_RS12600
uniprot id: M5DU20
names: Similarity
messages: Belongs to the UPF0145 family.

1298593:TOL RS04310
gene id: 1298593:TOL_RS04310
uniprot id: M5DQ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1298593:TOL RS12770
gene id: 1298593:TOL_RS12770
uniprot id: M5E6G4
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

1298593:TOL RS13950
gene id: 1298593:TOL_RS13950
uniprot id: M5DUQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1298593:TOL RS10760
gene id: 1298593:TOL_RS10760
uniprot id: M5E586
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1298593:TOL RS14780
gene id: 1298593:TOL_RS14780
uniprot id: M5DW02
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1298593:TOL RS13295
gene id: 1298593:TOL_RS13295
uniprot id: M5DTC3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1298593:TOL RS05480
gene id: 1298593:TOL_RS05480
uniprot id: M5E1Y5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS07875
gene id: 1298593:TOL_RS07875
uniprot id: M5DQ81
names: Similarity
messages: Belongs to the citrate synthase family.

1298593:TOL RS11830
gene id: 1298593:TOL_RS11830
uniprot id: M5DUC6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1298593:TOL RS17635
gene id: 1298593:TOL_RS17635
uniprot id: M5DW42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1298593:TOL RS12165
gene id: 1298593:TOL_RS12165
uniprot id: M5DU22
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1298593:TOL RS06280
gene id: 1298593:TOL_RS06280
uniprot id: M5DQM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1298593:TOL RS02420
gene id: 1298593:TOL_RS02420
uniprot id: M5DNC0
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

1298593:TOL RS04090
gene id: 1298593:TOL_RS04090
uniprot id: M5DMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1298593:TOL RS00780
gene id: 1298593:TOL_RS00780
uniprot id: M5DLG4
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

1298593:TOL RS16135
gene id: 1298593:TOL_RS16135
uniprot id: M5E8M4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1298593:TOL RS05275
gene id: 1298593:TOL_RS05275
uniprot id: M5DQ58
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

1298593:TOL RS13000
gene id: 1298593:TOL_RS13000
uniprot id: M5DT73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.

1298593:TOL RS04465
gene id: 1298593:TOL_RS04465
uniprot id: M5DN45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1298593:TOL RS07155
gene id: 1298593:TOL_RS07155
uniprot id: M5E2W9
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1298593:TOL RS00170
gene id: 1298593:TOL_RS00170
uniprot id: M5DMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1298593:TOL RS04400
gene id: 1298593:TOL_RS04400
uniprot id: M5DQ90
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

1298593:TOL RS01220
gene id: 1298593:TOL_RS01220
uniprot id: M5DLM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1298593:TOL RS03105
gene id: 1298593:TOL_RS03105
uniprot id: M5DNR2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1298593:TOL RS16740
gene id: 1298593:TOL_RS16740
uniprot id: M5DW98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1298593:TOL RS10090
gene id: 1298593:TOL_RS10090
uniprot id: M5DTH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1298593:TOL RS05000
gene id: 1298593:TOL_RS05000
uniprot id: M5E1G2
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1298593:TOL RS07975
gene id: 1298593:TOL_RS07975
uniprot id: M5DQ96
names: PTM
messages: Binds 1 heme group per subunit.

1298593:TOL RS03435
gene id: 1298593:TOL_RS03435
uniprot id: M5DML7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1298593:TOL RS00495
gene id: 1298593:TOL_RS00495
uniprot id: M5DLC2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1298593:TOL RS01055
gene id: 1298593:TOL_RS01055
uniprot id: M5DMT0
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

1298593:TOL RS17830
gene id: 1298593:TOL_RS17830
uniprot id: M5DW75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1298593:TOL RS04590
gene id: 1298593:TOL_RS04590
uniprot id: M5DPH6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1298593:TOL RS10455
gene id: 1298593:TOL_RS10455
uniprot id: M5DSV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1298593:TOL RS05995
gene id: 1298593:TOL_RS05995
uniprot id: M5E264
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1298593:TOL RS08485
gene id: 1298593:TOL_RS08485
uniprot id: M5DQI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

1298593:TOL RS16630
gene id: 1298593:TOL_RS16630
uniprot id: M5DWW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1298593:TOL RS09090
gene id: 1298593:TOL_RS09090
uniprot id: M5DQT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1298593:TOL RS01535
gene id: 1298593:TOL_RS01535
uniprot id: M5DZ07
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1298593:TOL RS00210
gene id: 1298593:TOL_RS00210
uniprot id: M5DN33
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1298593:TOL RS08090
gene id: 1298593:TOL_RS08090
uniprot id: M5E3M7
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS02675
gene id: 1298593:TOL_RS02675
uniprot id: M5DNH5
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS01035
gene id: 1298593:TOL_RS01035
uniprot id: M5DNF0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1298593:TOL RS04640
gene id: 1298593:TOL_RS04640
uniprot id: M5DPI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS04265
gene id: 1298593:TOL_RS04265
uniprot id: M5DQ62
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS17865
gene id: 1298593:TOL_RS17865
uniprot id: M5DXK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1298593:TOL RS11635
gene id: 1298593:TOL_RS11635
uniprot id: M5DU87
names: Similarity
messages: Belongs to the glutamine synthetase family.

1298593:TOL RS11745
gene id: 1298593:TOL_RS11745
uniprot id: M5DSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1298593:TOL RS06155
gene id: 1298593:TOL_RS06155
uniprot id: M5DQK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

1298593:TOL RS00325
gene id: 1298593:TOL_RS00325
uniprot id: M5DMG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1298593:TOL RS08110
gene id: 1298593:TOL_RS08110
uniprot id: M5DRI5
names: Similarity
messages: Belongs to the transposase 7 family.

1298593:TOL RS08910
gene id: 1298593:TOL_RS08910
uniprot id: M5DSS8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1298593:TOL RS08745
gene id: 1298593:TOL_RS08745
uniprot id: M5DRT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS14500
gene id: 1298593:TOL_RS14500
uniprot id: M5E7J1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1298593:TOL RS00370
gene id: 1298593:TOL_RS00370
uniprot id: M5DL97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

1298593:TOL RS13675
gene id: 1298593:TOL_RS13675
uniprot id: M5DUY8
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

1298593:TOL RS15020
gene id: 1298593:TOL_RS15020
uniprot id: M5DVE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1298593:TOL RS13250
gene id: 1298593:TOL_RS13250
uniprot id: M5DUR5
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

1298593:TOL RS11930
gene id: 1298593:TOL_RS11930
uniprot id: M5E5X1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1298593:TOL RS07105
gene id: 1298593:TOL_RS07105
uniprot id: M5DQX0
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

1298593:TOL RS09895
gene id: 1298593:TOL_RS09895
uniprot id: M5DTD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS13210
gene id: 1298593:TOL_RS13210
uniprot id: M5DUD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1298593:TOL RS12455
gene id: 1298593:TOL_RS12455
uniprot id: M5DTY5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

1298593:TOL RS09340
gene id: 1298593:TOL_RS09340
uniprot id: M5E4B9
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

1298593:TOL RS08115
gene id: 1298593:TOL_RS08115
uniprot id: M5E3N0
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.

1298593:TOL RS12020
gene id: 1298593:TOL_RS12020
uniprot id: M5DUG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

1298593:TOL RS09200
gene id: 1298593:TOL_RS09200
uniprot id: M5DSA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1298593:TOL RS17945
gene id: 1298593:TOL_RS17945
uniprot id: M5DWZ3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS04520
gene id: 1298593:TOL_RS04520
uniprot id: M5DPG0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1298593:TOL RS11760
gene id: 1298593:TOL_RS11760
uniprot id: M5DTI3
names: Similarity
messages: Belongs to the Skp family.

1298593:TOL RS05100
gene id: 1298593:TOL_RS05100
uniprot id: M5DNG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1298593:TOL RS01030
gene id: 1298593:TOL_RS01030
uniprot id: M5DMS7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1298593:TOL RS13680
gene id: 1298593:TOL_RS13680
uniprot id: M5DVD4
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1298593:TOL RS14510
gene id: 1298593:TOL_RS14510
uniprot id: M5DVF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1298593:TOL RS14315
gene id: 1298593:TOL_RS14315
uniprot id: M5DVQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

1298593:TOL RS06340
gene id: 1298593:TOL_RS06340
uniprot id: M5DRE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

1298593:TOL RS13215
gene id: 1298593:TOL_RS13215
uniprot id: M5E6P6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1298593:TOL RS07925
gene id: 1298593:TOL_RS07925
uniprot id: M5DQ88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1298593:TOL RS16435
gene id: 1298593:TOL_RS16435
uniprot id: M5DV77
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1298593:TOL RS12505
gene id: 1298593:TOL_RS12505
uniprot id: M5DSW1
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

1298593:TOL RS15830
gene id: 1298593:TOL_RS15830
uniprot id: M5DVT3
names: Subunit
messages: Homodimer.

1298593:TOL RS07425
gene id: 1298593:TOL_RS07425
uniprot id: M5DRA5
names: Subcellular Location Annotation
messages: Membrane

1298593:TOL RS15785
gene id: 1298593:TOL_RS15785
uniprot id: M5E8G7
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1298593:TOL RS14225
gene id: 1298593:TOL_RS14225
uniprot id: M5E7B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1298593:TOL RS05590
gene id: 1298593:TOL_RS05590
uniprot id: M5DNQ5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

1298593:TOL RS07795
gene id: 1298593:TOL_RS07795
uniprot id: M5E3H8
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

1298593:TOL RS09185
gene id: 1298593:TOL_RS09185
uniprot id: M5DQV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

1298593:TOL RS08615
gene id: 1298593:TOL_RS08615
uniprot id: M5DSN5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1298593:TOL RS06390
gene id: 1298593:TOL_RS06390
uniprot id: M5DQG2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1298593:TOL RS10900
gene id: 1298593:TOL_RS10900
uniprot id: M5DT13
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1298593:TOL RS12795
gene id: 1298593:TOL_RS12795
uniprot id: M5E6G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

1298593:TOL RS09065
gene id: 1298593:TOL_RS09065
uniprot id: M5DQT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1298593:TOL RS14000
gene id: 1298593:TOL_RS14000
uniprot id: M5DUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1298593:TOL RS04555
gene id: 1298593:TOL_RS04555
uniprot id: M5DPN9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1298593:TOL RS14920
gene id: 1298593:TOL_RS14920
uniprot id: M5DVC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

1298593:TOL RS09850
gene id: 1298593:TOL_RS09850
uniprot id: M5DSF5
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

1298593:TOL RS10305
gene id: 1298593:TOL_RS10305
uniprot id: M5DST1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1298593:TOL RS01125
gene id: 1298593:TOL_RS01125
uniprot id: M5DLK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1298593:TOL RS03890
gene id: 1298593:TOL_RS03890
uniprot id: M5DMU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

1298593:TOL RS07190
gene id: 1298593:TOL_RS07190
uniprot id: M5DR51
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

1298593:TOL RS11370
gene id: 1298593:TOL_RS11370
uniprot id: M5DTK2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1298593:TOL RS04600
gene id: 1298593:TOL_RS04600
uniprot id: M5DN69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1298593:TOL RS14875
gene id: 1298593:TOL_RS14875
uniprot id: M5E7X8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1298593:TOL RS00010
gene id: 1298593:TOL_RS00010
uniprot id: M5DMB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1298593:TOL RS04720
gene id: 1298593:TOL_RS04720
uniprot id: M5E166
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1298593:TOL RS04660
gene id: 1298593:TOL_RS04660
uniprot id: M5DQG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

1298593:TOL RS10535
gene id: 1298593:TOL_RS10535
uniprot id: M5DTQ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1298593:TOL RS03180
gene id: 1298593:TOL_RS03180
uniprot id: M5E030
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1298593:TOL RS15525
gene id: 1298593:TOL_RS15525
uniprot id: M5DVP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1298593:TOL RS00020
gene id: 1298593:TOL_RS00020
uniprot id: M5DM76
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1298593:TOL RS06475
gene id: 1298593:TOL_RS06475
uniprot id: M5DQI2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.