1276246:SCULI RS00155
gene id: 1276246:SCULI_RS00155
uniprot id: W6A5V6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1276246:SCULI RS00005
gene id: 1276246:SCULI_RS00005
uniprot id: W6A5S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1276246:SCULI RS02105
gene id: 1276246:SCULI_RS02105
uniprot id: W6A6Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1276246:SCULI RS01515
gene id: 1276246:SCULI_RS01515
uniprot id: W6A6X4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1276246:SCULI RS00935
gene id: 1276246:SCULI_RS00935
uniprot id: W6A6L4
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1276246:SCULI RS00425
gene id: 1276246:SCULI_RS00425
uniprot id: W6A653
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1276246:SCULI RS03445
gene id: 1276246:SCULI_RS03445
uniprot id: W6AH58
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1276246:SCULI RS02340
gene id: 1276246:SCULI_RS02340
uniprot id: W6AGI9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1276246:SCULI RS01275
gene id: 1276246:SCULI_RS01275
uniprot id: W6A6F7
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00095
gene id: 1276246:SCULI_RS00095
uniprot id: W6A695
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1276246:SCULI RS00045
gene id: 1276246:SCULI_RS00045
uniprot id: W6A684
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1276246:SCULI RS02620
gene id: 1276246:SCULI_RS02620
uniprot id: W6A7L9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1276246:SCULI RS03005
gene id: 1276246:SCULI_RS03005
uniprot id: W6A7G4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1276246:SCULI RS05110
gene id: 1276246:SCULI_RS05110
uniprot id: W6A8P7
names: Similarity
messages: Belongs to the peptidase M17 family.

1276246:SCULI RS02270
gene id: 1276246:SCULI_RS02270
uniprot id: W6A7G0
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1276246:SCULI RS05340
gene id: 1276246:SCULI_RS05340
uniprot id: W6A8P0
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS02350
gene id: 1276246:SCULI_RS02350
uniprot id: W6A748
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS03695
gene id: 1276246:SCULI_RS03695
uniprot id: W6A855
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1276246:SCULI RS04215
gene id: 1276246:SCULI_RS04215
uniprot id: W6A861
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1276246:SCULI RS02130
gene id: 1276246:SCULI_RS02130
uniprot id: W6A6Y9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS04815
gene id: 1276246:SCULI_RS04815
uniprot id: W6A8F1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1276246:SCULI RS02925
gene id: 1276246:SCULI_RS02925
uniprot id: W6A7F0
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

1276246:SCULI RS05415
gene id: 1276246:SCULI_RS05415
uniprot id: W6A8B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1276246:SCULI RS00530
gene id: 1276246:SCULI_RS00530
uniprot id: W6A626
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1276246:SCULI RS01315
gene id: 1276246:SCULI_RS01315
uniprot id: W6A6T7
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS03395
gene id: 1276246:SCULI_RS03395
uniprot id: W6AH46
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS02145
gene id: 1276246:SCULI_RS02145
uniprot id: W6A7D9
names: Similarity
messages: Belongs to the RibF family.

1276246:SCULI RS04315
gene id: 1276246:SCULI_RS04315
uniprot id: W6A888
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS03135
gene id: 1276246:SCULI_RS03135
uniprot id: W6AGY9
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1276246:SCULI RS00195
gene id: 1276246:SCULI_RS00195
uniprot id: W6A6B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1276246:SCULI RS02500
gene id: 1276246:SCULI_RS02500
uniprot id: W6A773
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1276246:SCULI RS05400
gene id: 1276246:SCULI_RS05400
uniprot id: W6A931
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1276246:SCULI RS03830
gene id: 1276246:SCULI_RS03830
uniprot id: W6A7X1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276246:SCULI RS03600
gene id: 1276246:SCULI_RS03600
uniprot id: W6AH84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1276246:SCULI RS01285
gene id: 1276246:SCULI_RS01285
uniprot id: W6AFU6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS04925
gene id: 1276246:SCULI_RS04925
uniprot id: W6AHY1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1276246:SCULI RS01850
gene id: 1276246:SCULI_RS01850
uniprot id: W6A6V6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1276246:SCULI RS03590
gene id: 1276246:SCULI_RS03590
uniprot id: W6A7T1
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS04820
gene id: 1276246:SCULI_RS04820
uniprot id: W6A825
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1276246:SCULI RS04035
gene id: 1276246:SCULI_RS04035
uniprot id: W6A7L8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1276246:SCULI RS02555
gene id: 1276246:SCULI_RS02555
uniprot id: W6A767
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1276246:SCULI RS00515
gene id: 1276246:SCULI_RS00515
uniprot id: W6AFH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1276246:SCULI RS02680
gene id: 1276246:SCULI_RS02680
uniprot id: W6A789
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1276246:SCULI RS02920
gene id: 1276246:SCULI_RS02920
uniprot id: W6A7R4
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1276246:SCULI RS00535
gene id: 1276246:SCULI_RS00535
uniprot id: W6A5P0
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276246:SCULI RS02075
gene id: 1276246:SCULI_RS02075
uniprot id: W6A6Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1276246:SCULI RS04875
gene id: 1276246:SCULI_RS04875
uniprot id: W6AHW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1276246:SCULI RS00635
gene id: 1276246:SCULI_RS00635
uniprot id: W6AFK0
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1276246:SCULI RS03240
gene id: 1276246:SCULI_RS03240
uniprot id: W6A7W4
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS03110
gene id: 1276246:SCULI_RS03110
uniprot id: W6AGY4
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS03970
gene id: 1276246:SCULI_RS03970
uniprot id: W6A898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276246:SCULI RS04760
gene id: 1276246:SCULI_RS04760
uniprot id: W6A8I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1276246:SCULI RS04330
gene id: 1276246:SCULI_RS04330
uniprot id: W6A8I9
names: Similarity
messages: Belongs to the asp23 family.

1276246:SCULI RS04485
gene id: 1276246:SCULI_RS04485
uniprot id: W6A8K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

1276246:SCULI RS04895
gene id: 1276246:SCULI_RS04895
uniprot id: W6A836
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1276246:SCULI RS04400
gene id: 1276246:SCULI_RS04400
uniprot id: W6A7W5
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00650
gene id: 1276246:SCULI_RS00650
uniprot id: W6A648
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1276246:SCULI RS01075
gene id: 1276246:SCULI_RS01075
uniprot id: W6A5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1276246:SCULI RS03610
gene id: 1276246:SCULI_RS03610
uniprot id: W6A7T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1276246:SCULI RS01305
gene id: 1276246:SCULI_RS01305
uniprot id: W6A642
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1276246:SCULI RS02525
gene id: 1276246:SCULI_RS02525
uniprot id: W6A776
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1276246:SCULI RS02730
gene id: 1276246:SCULI_RS02730
uniprot id: W6A7A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1276246:SCULI RS01670
gene id: 1276246:SCULI_RS01670
uniprot id: W6A6R3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1276246:SCULI RS03620
gene id: 1276246:SCULI_RS03620
uniprot id: W6AH87
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1276246:SCULI RS04945
gene id: 1276246:SCULI_RS04945
uniprot id: W6A845
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1276246:SCULI RS05660
gene id: 1276246:SCULI_RS05660
uniprot id: W6AH41
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS00310
gene id: 1276246:SCULI_RS00310
uniprot id: W6A5J6
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

1276246:SCULI RS04320
gene id: 1276246:SCULI_RS04320
uniprot id: W6A7U0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1276246:SCULI RS05235
gene id: 1276246:SCULI_RS05235
uniprot id: W6A8S6
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1276246:SCULI RS03890
gene id: 1276246:SCULI_RS03890
uniprot id: W6AHD9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1276246:SCULI RS01610
gene id: 1276246:SCULI_RS01610
uniprot id: W6AG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1276246:SCULI RS05190
gene id: 1276246:SCULI_RS05190
uniprot id: W6A8L1
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1276246:SCULI RS04125
gene id: 1276246:SCULI_RS04125
uniprot id: W6A7N1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1276246:SCULI RS02290
gene id: 1276246:SCULI_RS02290
uniprot id: W6AGH9
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1276246:SCULI RS04930
gene id: 1276246:SCULI_RS04930
uniprot id: W6A8T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1276246:SCULI RS05305
gene id: 1276246:SCULI_RS05305
uniprot id: W6A911
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04025
gene id: 1276246:SCULI_RS04025
uniprot id: W6A819
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1276246:SCULI RS03465
gene id: 1276246:SCULI_RS03465
uniprot id: W6A7A1
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS04115
gene id: 1276246:SCULI_RS04115
uniprot id: W6A838
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1276246:SCULI RS03425
gene id: 1276246:SCULI_RS03425
uniprot id: W6A801
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

1276246:SCULI RS03740
gene id: 1276246:SCULI_RS03740
uniprot id: W6AHB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1276246:SCULI RS05335
gene id: 1276246:SCULI_RS05335
uniprot id: W6A8U6
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS05065
gene id: 1276246:SCULI_RS05065
uniprot id: W6A8I8
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1276246:SCULI RS01465
gene id: 1276246:SCULI_RS01465
uniprot id: W6A6W4
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1276246:SCULI RS02805
gene id: 1276246:SCULI_RS02805
uniprot id: W6A7B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

1276246:SCULI RS00215
gene id: 1276246:SCULI_RS00215
uniprot id: W6AFC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1276246:SCULI RS02870
gene id: 1276246:SCULI_RS02870
uniprot id: W6A7Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276246:SCULI RS03120
gene id: 1276246:SCULI_RS03120
uniprot id: W6A7J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1276246:SCULI RS02705
gene id: 1276246:SCULI_RS02705
uniprot id: W6A795
names: Function
names: Similarity
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

1276246:SCULI RS01015
gene id: 1276246:SCULI_RS01015
uniprot id: W6A6E7
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276246:SCULI RS03115
gene id: 1276246:SCULI_RS03115
uniprot id: W6A7U5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

1276246:SCULI RS04295
gene id: 1276246:SCULI_RS04295
uniprot id: W6A869
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1276246:SCULI RS01930
gene id: 1276246:SCULI_RS01930
uniprot id: W6A6W0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1276246:SCULI RS05300
gene id: 1276246:SCULI_RS05300
uniprot id: W6AI46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1276246:SCULI RS04365
gene id: 1276246:SCULI_RS04365
uniprot id: W6A8C2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1276246:SCULI RS04250
gene id: 1276246:SCULI_RS04250
uniprot id: W6A7Q9
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS04530
gene id: 1276246:SCULI_RS04530
uniprot id: W6AHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1276246:SCULI RS05685
gene id: 1276246:SCULI_RS05685
uniprot id: W6A711
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS02970
gene id: 1276246:SCULI_RS02970
uniprot id: W6A7S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1276246:SCULI RS00600
gene id: 1276246:SCULI_RS00600
uniprot id: W6A639
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1276246:SCULI RS05245
gene id: 1276246:SCULI_RS05245
uniprot id: W6A885
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1276246:SCULI RS03900
gene id: 1276246:SCULI_RS03900
uniprot id: W6A7Y9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1276246:SCULI RS01505
gene id: 1276246:SCULI_RS01505
uniprot id: W6A682
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1276246:SCULI RS01245
gene id: 1276246:SCULI_RS01245
uniprot id: W6A6I1
names: Similarity
messages: Belongs to the pyruvate kinase family.

1276246:SCULI RS01320
gene id: 1276246:SCULI_RS01320
uniprot id: W6A6J4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276246:SCULI RS01145
gene id: 1276246:SCULI_RS01145
uniprot id: W6A6G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1276246:SCULI RS04825
gene id: 1276246:SCULI_RS04825
uniprot id: W6AHW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1276246:SCULI RS03895
gene id: 1276246:SCULI_RS03895
uniprot id: W6A884
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS04175
gene id: 1276246:SCULI_RS04175
uniprot id: W6A7P1
names: Similarity
messages: Belongs to the CutC family.

1276246:SCULI RS01215
gene id: 1276246:SCULI_RS01215
uniprot id: W6A6S2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1276246:SCULI RS05390
gene id: 1276246:SCULI_RS05390
uniprot id: W6A8A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1276246:SCULI RS01805
gene id: 1276246:SCULI_RS01805
uniprot id: W6A6H9
names: Similarity
messages: Belongs to the DprA/Smf family.

1276246:SCULI RS05360
gene id: 1276246:SCULI_RS05360
uniprot id: W6A8V2
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1276246:SCULI RS02530
gene id: 1276246:SCULI_RS02530
uniprot id: W6A762
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04170
gene id: 1276246:SCULI_RS04170
uniprot id: W6A842
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1276246:SCULI RS04940
gene id: 1276246:SCULI_RS04940
uniprot id: W6A8H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1276246:SCULI RS04415
gene id: 1276246:SCULI_RS04415
uniprot id: W6A8D0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS05145
gene id: 1276246:SCULI_RS05145
uniprot id: W6A874
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1276246:SCULI RS03540
gene id: 1276246:SCULI_RS03540
uniprot id: W6A7S4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1276246:SCULI RS04350
gene id: 1276246:SCULI_RS04350
uniprot id: W6A7V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1276246:SCULI RS00880
gene id: 1276246:SCULI_RS00880
uniprot id: W6AFM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01855
gene id: 1276246:SCULI_RS01855
uniprot id: W6A6U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1276246:SCULI RS05290
gene id: 1276246:SCULI_RS05290
uniprot id: W6A8N2
names: Similarity
messages: Belongs to the RpoE family.

1276246:SCULI RS00435
gene id: 1276246:SCULI_RS00435
uniprot id: W6A5M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1276246:SCULI RS05275
gene id: 1276246:SCULI_RS05275
uniprot id: W6AI42
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1276246:SCULI RS00540
gene id: 1276246:SCULI_RS00540
uniprot id: W6AFI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1276246:SCULI RS02875
gene id: 1276246:SCULI_RS02875
uniprot id: W6A7E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276246:SCULI RS02450
gene id: 1276246:SCULI_RS02450
uniprot id: W6A765
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276246:SCULI RS03440
gene id: 1276246:SCULI_RS03440
uniprot id: W6A797
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1276246:SCULI RS04705
gene id: 1276246:SCULI_RS04705
uniprot id: W6A8P4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1276246:SCULI RS01635
gene id: 1276246:SCULI_RS01635
uniprot id: W6AG20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1276246:SCULI RS04720
gene id: 1276246:SCULI_RS04720
uniprot id: W6A809
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04075
gene id: 1276246:SCULI_RS04075
uniprot id: W6A7M3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1276246:SCULI RS04585
gene id: 1276246:SCULI_RS04585
uniprot id: W6A7Z1
names: Similarity
messages: Belongs to the Fur family.

1276246:SCULI RS04395
gene id: 1276246:SCULI_RS04395
uniprot id: W6A896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1276246:SCULI RS05105
gene id: 1276246:SCULI_RS05105
uniprot id: W6A8X2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1276246:SCULI RS04460
gene id: 1276246:SCULI_RS04460
uniprot id: W6A8K5
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

1276246:SCULI RS02910
gene id: 1276246:SCULI_RS02910
uniprot id: W6A6Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1276246:SCULI RS04710
gene id: 1276246:SCULI_RS04710
uniprot id: W6A8H4
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1276246:SCULI RS04245
gene id: 1276246:SCULI_RS04245
uniprot id: W6A857
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS03945
gene id: 1276246:SCULI_RS03945
uniprot id: W6A892
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00405
gene id: 1276246:SCULI_RS00405
uniprot id: W6A600
names: Similarity
messages: Belongs to the Lgt family.

1276246:SCULI RS05185
gene id: 1276246:SCULI_RS05185
uniprot id: W6A8R5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1276246:SCULI RS00040
gene id: 1276246:SCULI_RS00040
uniprot id: W6AF95
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1276246:SCULI RS05495
gene id: 1276246:SCULI_RS05495
uniprot id: W6A6W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1276246:SCULI RS01580
gene id: 1276246:SCULI_RS01580
uniprot id: W6A696
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1276246:SCULI RS00575
gene id: 1276246:SCULI_RS00575
uniprot id: W6A636
names: Subcellular Location Annotation
messages: Cytoplasm

1276246:SCULI RS00250
gene id: 1276246:SCULI_RS00250
uniprot id: W6A620
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1276246:SCULI RS05540
gene id: 1276246:SCULI_RS05540
uniprot id: W6AHA2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1276246:SCULI RS05385
gene id: 1276246:SCULI_RS05385
uniprot id: W6A8Q1
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.

1276246:SCULI RS01920
gene id: 1276246:SCULI_RS01920
uniprot id: W6A7A2
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1276246:SCULI RS01775
gene id: 1276246:SCULI_RS01775
uniprot id: W6A6R0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1276246:SCULI RS03455
gene id: 1276246:SCULI_RS03455
uniprot id: W6A7Q7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1276246:SCULI RS04890
gene id: 1276246:SCULI_RS04890
uniprot id: W6A8G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1276246:SCULI RS00010
gene id: 1276246:SCULI_RS00010
uniprot id: W6A5E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1276246:SCULI RS00255
gene id: 1276246:SCULI_RS00255
uniprot id: W6A5X4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1276246:SCULI RS00375
gene id: 1276246:SCULI_RS00375
uniprot id: W6A647
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1276246:SCULI RS02440
gene id: 1276246:SCULI_RS02440
uniprot id: W6AGK6
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS05130
gene id: 1276246:SCULI_RS05130
uniprot id: W6A8X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1276246:SCULI RS04655
gene id: 1276246:SCULI_RS04655
uniprot id: W6A8G8
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1276246:SCULI RS02295
gene id: 1276246:SCULI_RS02295
uniprot id: W6A7G5
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

1276246:SCULI RS03145
gene id: 1276246:SCULI_RS03145
uniprot id: W6A7J7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS04005
gene id: 1276246:SCULI_RS04005
uniprot id: W6A811
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1276246:SCULI RS03865
gene id: 1276246:SCULI_RS03865
uniprot id: W6AHD6
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1276246:SCULI RS05330
gene id: 1276246:SCULI_RS05330
uniprot id: W6A917
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1276246:SCULI RS04695
gene id: 1276246:SCULI_RS04695
uniprot id: W6A806
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01370
gene id: 1276246:SCULI_RS01370
uniprot id: W6A6K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1276246:SCULI RS04805
gene id: 1276246:SCULI_RS04805
uniprot id: W6A8R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1276246:SCULI RS02710
gene id: 1276246:SCULI_RS02710
uniprot id: W6A6W1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1276246:SCULI RS00035
gene id: 1276246:SCULI_RS00035
uniprot id: W6A5E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1276246:SCULI RS01400
gene id: 1276246:SCULI_RS01400
uniprot id: W6A6I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

1276246:SCULI RS00285
gene id: 1276246:SCULI_RS00285
uniprot id: W6A5J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1276246:SCULI RS04010
gene id: 1276246:SCULI_RS04010
uniprot id: W6A7L2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1276246:SCULI RS00180
gene id: 1276246:SCULI_RS00180
uniprot id: W6A5W1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1276246:SCULI RS04495
gene id: 1276246:SCULI_RS04495
uniprot id: W6A8A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1276246:SCULI RS04765
gene id: 1276246:SCULI_RS04765
uniprot id: W6A8E4
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS01675
gene id: 1276246:SCULI_RS01675
uniprot id: W6A6N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1276246:SCULI RS03995
gene id: 1276246:SCULI_RS03995
uniprot id: W6A8A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1276246:SCULI RS00495
gene id: 1276246:SCULI_RS00495
uniprot id: W6A6F8
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS03675
gene id: 1276246:SCULI_RS03675
uniprot id: W6A7U8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1276246:SCULI RS01760
gene id: 1276246:SCULI_RS01760
uniprot id: W6AG41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1276246:SCULI RS03765
gene id: 1276246:SCULI_RS03765
uniprot id: W6AHC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1276246:SCULI RS03785
gene id: 1276246:SCULI_RS03785
uniprot id: W6A7G8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1276246:SCULI RS00410
gene id: 1276246:SCULI_RS00410
uniprot id: W6A5L6
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1276246:SCULI RS01650
gene id: 1276246:SCULI_RS01650
uniprot id: W6A6N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS02665
gene id: 1276246:SCULI_RS02665
uniprot id: W6AGP8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1276246:SCULI RS04675
gene id: 1276246:SCULI_RS04675
uniprot id: W6A8N9
names: Similarity
messages: Belongs to the peptidase M13 family.

1276246:SCULI RS05005
gene id: 1276246:SCULI_RS05005
uniprot id: W6A8V3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1276246:SCULI RS03905
gene id: 1276246:SCULI_RS03905
uniprot id: W6A7Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1276246:SCULI RS03770
gene id: 1276246:SCULI_RS03770
uniprot id: W6A868
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1276246:SCULI RS04775
gene id: 1276246:SCULI_RS04775
uniprot id: W6AHV6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04445
gene id: 1276246:SCULI_RS04445
uniprot id: W6A8A3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1276246:SCULI RS00120
gene id: 1276246:SCULI_RS00120
uniprot id: W6A698
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1276246:SCULI RS04845
gene id: 1276246:SCULI_RS04845
uniprot id: W6A829
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1276246:SCULI RS01620
gene id: 1276246:SCULI_RS01620
uniprot id: W6A6Q3
names: Similarity
messages: Belongs to the FBPase class 2 family.

1276246:SCULI RS05320
gene id: 1276246:SCULI_RS05320
uniprot id: W6A895
names: Similarity
messages: Belongs to the ParB family.

1276246:SCULI RS01520
gene id: 1276246:SCULI_RS01520
uniprot id: W6A6N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1276246:SCULI RS03750
gene id: 1276246:SCULI_RS03750
uniprot id: W6A7W3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276246:SCULI RS02360
gene id: 1276246:SCULI_RS02360
uniprot id: W6A6R7
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00275
gene id: 1276246:SCULI_RS00275
uniprot id: W6A625
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

1276246:SCULI RS02005
gene id: 1276246:SCULI_RS02005
uniprot id: W6A6X1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1276246:SCULI RS04830
gene id: 1276246:SCULI_RS04830
uniprot id: W6A8R9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1276246:SCULI RS00525
gene id: 1276246:SCULI_RS00525
uniprot id: W6A672
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1276246:SCULI RS01745
gene id: 1276246:SCULI_RS01745
uniprot id: W6A6S7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1276246:SCULI RS03580
gene id: 1276246:SCULI_RS03580
uniprot id: W6A828
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1276246:SCULI RS00905
gene id: 1276246:SCULI_RS00905
uniprot id: W6AFN3
names: Subcellular Location Annotation
messages: Cytoplasm

1276246:SCULI RS03790
gene id: 1276246:SCULI_RS03790
uniprot id: W6AHC6
names: Similarity
messages: Belongs to the peptidase M24B family.

1276246:SCULI RS04935
gene id: 1276246:SCULI_RS04935
uniprot id: W6A8K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1276246:SCULI RS01250
gene id: 1276246:SCULI_RS01250
uniprot id: W6A6F2
names: Similarity
messages: Belongs to the pyruvate kinase family.

1276246:SCULI RS00870
gene id: 1276246:SCULI_RS00870
uniprot id: W6A6B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

1276246:SCULI RS05455
gene id: 1276246:SCULI_RS05455
uniprot id: W6A8X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1276246:SCULI RS02140
gene id: 1276246:SCULI_RS02140
uniprot id: W6AGF5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1276246:SCULI RS00450
gene id: 1276246:SCULI_RS00450
uniprot id: W6A658
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04880
gene id: 1276246:SCULI_RS04880
uniprot id: W6A8S8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1276246:SCULI RS05140
gene id: 1276246:SCULI_RS05140
uniprot id: W6A8K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1276246:SCULI RS05350
gene id: 1276246:SCULI_RS05350
uniprot id: W6AI54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1276246:SCULI RS04915
gene id: 1276246:SCULI_RS04915
uniprot id: W6A8G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1276246:SCULI RS04465
gene id: 1276246:SCULI_RS04465
uniprot id: W6A8E0
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1276246:SCULI RS01445
gene id: 1276246:SCULI_RS01445
uniprot id: W6A6L8
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

1276246:SCULI RS03910
gene id: 1276246:SCULI_RS03910
uniprot id: W6A7J1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1276246:SCULI RS02265
gene id: 1276246:SCULI_RS02265
uniprot id: W6AGH5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1276246:SCULI RS03520
gene id: 1276246:SCULI_RS03520
uniprot id: W6A7B2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276246:SCULI RS02375
gene id: 1276246:SCULI_RS02375
uniprot id: W6A752
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

1276246:SCULI RS00015
gene id: 1276246:SCULI_RS00015
uniprot id: W6AF92
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1276246:SCULI RS05430
gene id: 1276246:SCULI_RS05430
uniprot id: W6A8W6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01020
gene id: 1276246:SCULI_RS01020
uniprot id: W6A6A9
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS01820
gene id: 1276246:SCULI_RS01820
uniprot id: W6A6V4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276246:SCULI RS02915
gene id: 1276246:SCULI_RS02915
uniprot id: W6AGU2
names: Similarity
messages: Belongs to the XseB family.

1276246:SCULI RS01375
gene id: 1276246:SCULI_RS01375
uniprot id: W6A6H5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1276246:SCULI RS00400
gene id: 1276246:SCULI_RS00400
uniprot id: W6A650
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

1276246:SCULI RS01210
gene id: 1276246:SCULI_RS01210
uniprot id: W6AFT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1276246:SCULI RS05560
gene id: 1276246:SCULI_RS05560
uniprot id: W6AHW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1276246:SCULI RS00265
gene id: 1276246:SCULI_RS00265
uniprot id: W6AFC8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1276246:SCULI RS04095
gene id: 1276246:SCULI_RS04095
uniprot id: W6A826
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS00390
gene id: 1276246:SCULI_RS00390
uniprot id: W6AFF5
names: Similarity
messages: Belongs to the HPrK/P family.

1276246:SCULI RS00060
gene id: 1276246:SCULI_RS00060
uniprot id: W6A5E8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1276246:SCULI RS01680
gene id: 1276246:SCULI_RS01680
uniprot id: W6A6B8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1276246:SCULI RS02535
gene id: 1276246:SCULI_RS02535
uniprot id: W6A6T9
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1276246:SCULI RS02150
gene id: 1276246:SCULI_RS02150
uniprot id: W6A716
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1276246:SCULI RS03375
gene id: 1276246:SCULI_RS03375
uniprot id: W6A7Z2
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS02070
gene id: 1276246:SCULI_RS02070
uniprot id: W6A7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1276246:SCULI RS03795
gene id: 1276246:SCULI_RS03795
uniprot id: W6A873
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1276246:SCULI RS04870
gene id: 1276246:SCULI_RS04870
uniprot id: W6A833
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1276246:SCULI RS00550
gene id: 1276246:SCULI_RS00550
uniprot id: W6A676
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00395
gene id: 1276246:SCULI_RS00395
uniprot id: W6A6E3
names: Similarity
messages: Belongs to the Lgt family.

1276246:SCULI RS04380
gene id: 1276246:SCULI_RS04380
uniprot id: W6AHP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1276246:SCULI RS04885
gene id: 1276246:SCULI_RS04885
uniprot id: W6A8K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1276246:SCULI RS00335
gene id: 1276246:SCULI_RS00335
uniprot id: W6A5K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1276246:SCULI RS02940
gene id: 1276246:SCULI_RS02940
uniprot id: W6AGU7
names: Similarity
messages: Belongs to the TlyA family.

1276246:SCULI RS00145
gene id: 1276246:SCULI_RS00145
uniprot id: W6A6A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1276246:SCULI RS05470
gene id: 1276246:SCULI_RS05470
uniprot id: W6A670
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276246:SCULI RS03020
gene id: 1276246:SCULI_RS03020
uniprot id: W6A7S9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1276246:SCULI RS01055
gene id: 1276246:SCULI_RS01055
uniprot id: W6AFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1276246:SCULI RS00235
gene id: 1276246:SCULI_RS00235
uniprot id: W6A5I6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01450
gene id: 1276246:SCULI_RS01450
uniprot id: W6A6I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1276246:SCULI RS00130
gene id: 1276246:SCULI_RS00130
uniprot id: W6A5V0
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1276246:SCULI RS01825
gene id: 1276246:SCULI_RS01825
uniprot id: W6A6U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1276246:SCULI RS00260
gene id: 1276246:SCULI_RS00260
uniprot id: W6A5I8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1276246:SCULI RS05460
gene id: 1276246:SCULI_RS05460
uniprot id: W6A8R8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1276246:SCULI RS00470
gene id: 1276246:SCULI_RS00470
uniprot id: W6A6F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1276246:SCULI RS03855
gene id: 1276246:SCULI_RS03855
uniprot id: W6A7X7
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

1276246:SCULI RS05465
gene id: 1276246:SCULI_RS05465
uniprot id: W6AFD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1276246:SCULI RS01945
gene id: 1276246:SCULI_RS01945
uniprot id: W6A7A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01490
gene id: 1276246:SCULI_RS01490
uniprot id: W6A6W9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1276246:SCULI RS05545
gene id: 1276246:SCULI_RS05545
uniprot id: W6A7W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1276246:SCULI RS00025
gene id: 1276246:SCULI_RS00025
uniprot id: W6A5Y0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01070
gene id: 1276246:SCULI_RS01070
uniprot id: W6A6C0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS00020
gene id: 1276246:SCULI_RS00020
uniprot id: W6A681
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

1276246:SCULI RS00430
gene id: 1276246:SCULI_RS00430
uniprot id: W6A607
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1276246:SCULI RS01240
gene id: 1276246:SCULI_RS01240
uniprot id: W6A6S5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04835
gene id: 1276246:SCULI_RS04835
uniprot id: W6A8J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1276246:SCULI RS05135
gene id: 1276246:SCULI_RS05135
uniprot id: W6A8Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1276246:SCULI RS00445
gene id: 1276246:SCULI_RS00445
uniprot id: W6A6F0
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS03760
gene id: 1276246:SCULI_RS03760
uniprot id: W6A7G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1276246:SCULI RS00565
gene id: 1276246:SCULI_RS00565
uniprot id: W6AFI9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1276246:SCULI RS01545
gene id: 1276246:SCULI_RS01545
uniprot id: W6A6N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1276246:SCULI RS01770
gene id: 1276246:SCULI_RS01770
uniprot id: W6A6T3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1276246:SCULI RS00185
gene id: 1276246:SCULI_RS00185
uniprot id: W6A5H5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1276246:SCULI RS00760
gene id: 1276246:SCULI_RS00760
uniprot id: W6A5S6
names: Similarity
messages: Belongs to the thioredoxin family.

1276246:SCULI RS01905
gene id: 1276246:SCULI_RS01905
uniprot id: W6A6V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1276246:SCULI RS01065
gene id: 1276246:SCULI_RS01065
uniprot id: W6A6F5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1276246:SCULI RS04195
gene id: 1276246:SCULI_RS04195
uniprot id: W6A846
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1276246:SCULI RS01880
gene id: 1276246:SCULI_RS01880
uniprot id: W6A6V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1276246:SCULI RS02055
gene id: 1276246:SCULI_RS02055
uniprot id: W6A6X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1276246:SCULI RS00505
gene id: 1276246:SCULI_RS00505
uniprot id: W6A621
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

1276246:SCULI RS05050
gene id: 1276246:SCULI_RS05050
uniprot id: W6AI04
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1276246:SCULI RS01665
gene id: 1276246:SCULI_RS01665
uniprot id: W6A709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1276246:SCULI RS03885
gene id: 1276246:SCULI_RS03885
uniprot id: W6A7I6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1276246:SCULI RS00300
gene id: 1276246:SCULI_RS00300
uniprot id: W6A630
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1276246:SCULI RS03870
gene id: 1276246:SCULI_RS03870
uniprot id: W6A881
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04910
gene id: 1276246:SCULI_RS04910
uniprot id: W6A8K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1276246:SCULI RS00170
gene id: 1276246:SCULI_RS00170
uniprot id: W6A6A8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1276246:SCULI RS04810
gene id: 1276246:SCULI_RS04810
uniprot id: W6A8I7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1276246:SCULI RS01225
gene id: 1276246:SCULI_RS01225
uniprot id: W6A6E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1276246:SCULI RS04715
gene id: 1276246:SCULI_RS04715
uniprot id: W6A8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1276246:SCULI RS01355
gene id: 1276246:SCULI_RS01355
uniprot id: W6A652
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS05310
gene id: 1276246:SCULI_RS05310
uniprot id: W6A8U1
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1276246:SCULI RS04185
gene id: 1276246:SCULI_RS04185
uniprot id: W6A8E3
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276246:SCULI RS04780
gene id: 1276246:SCULI_RS04780
uniprot id: W6A8Q8
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00305
gene id: 1276246:SCULI_RS00305
uniprot id: W6A5Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1276246:SCULI RS03735
gene id: 1276246:SCULI_RS03735
uniprot id: W6A7F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

1276246:SCULI RS02030
gene id: 1276246:SCULI_RS02030
uniprot id: W6A6X3
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS03140
gene id: 1276246:SCULI_RS03140
uniprot id: W6A7U9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS01965
gene id: 1276246:SCULI_RS01965
uniprot id: W6AGD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1276246:SCULI RS00510
gene id: 1276246:SCULI_RS00510
uniprot id: W6A5N4
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1276246:SCULI RS01540
gene id: 1276246:SCULI_RS01540
uniprot id: W6A6X9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS00370
gene id: 1276246:SCULI_RS00370
uniprot id: W6A6E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1276246:SCULI RS05510
gene id: 1276246:SCULI_RS05510
uniprot id: W6A747
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1276246:SCULI RS03935
gene id: 1276246:SCULI_RS03935
uniprot id: W6A7J6
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00115
gene id: 1276246:SCULI_RS00115
uniprot id: W6AFA9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01785
gene id: 1276246:SCULI_RS01785
uniprot id: W6AG72
names: Similarity
messages: Belongs to the RutC family.

1276246:SCULI RS03150
gene id: 1276246:SCULI_RS03150
uniprot id: W6A7J5
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS01380
gene id: 1276246:SCULI_RS01380
uniprot id: W6A656
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1276246:SCULI RS02645
gene id: 1276246:SCULI_RS02645
uniprot id: W6A7M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1276246:SCULI RS04950
gene id: 1276246:SCULI_RS04950
uniprot id: W6AHY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1276246:SCULI RS00245
gene id: 1276246:SCULI_RS00245
uniprot id: W6A6C1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276246:SCULI RS04305
gene id: 1276246:SCULI_RS04305
uniprot id: W6A8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1276246:SCULI RS02155
gene id: 1276246:SCULI_RS02155
uniprot id: W6A6Z6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1276246:SCULI RS00295
gene id: 1276246:SCULI_RS00295
uniprot id: W6A6C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1276246:SCULI RS05365
gene id: 1276246:SCULI_RS05365
uniprot id: W6A8P6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1276246:SCULI RS01690
gene id: 1276246:SCULI_RS01690
uniprot id: W6A715
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Cytoplasm

1276246:SCULI RS01335
gene id: 1276246:SCULI_RS01335
uniprot id: W6AFV6
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS04750
gene id: 1276246:SCULI_RS04750
uniprot id: W6AHV1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1276246:SCULI RS04865
gene id: 1276246:SCULI_RS04865
uniprot id: W6A8F9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1276246:SCULI RS01765
gene id: 1276246:SCULI_RS01765
uniprot id: W6A735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

1276246:SCULI RS02625
gene id: 1276246:SCULI_RS02625
uniprot id: W6A794
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1276246:SCULI RS02845
gene id: 1276246:SCULI_RS02845
uniprot id: W6A7Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1276246:SCULI RS01810
gene id: 1276246:SCULI_RS01810
uniprot id: W6AGA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1276246:SCULI RS03965
gene id: 1276246:SCULI_RS03965
uniprot id: W6AHE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276246:SCULI RS05285
gene id: 1276246:SCULI_RS05285
uniprot id: W6A8T6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS03700
gene id: 1276246:SCULI_RS03700
uniprot id: W6A7V3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1276246:SCULI RS02635
gene id: 1276246:SCULI_RS02635
uniprot id: W6A6U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 2 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1276246:SCULI RS01005
gene id: 1276246:SCULI_RS01005
uniprot id: W6AFP6
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1276246:SCULI RS02695
gene id: 1276246:SCULI_RS02695
uniprot id: W6A7M8
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS04840
gene id: 1276246:SCULI_RS04840
uniprot id: W6A8F5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1276246:SCULI RS01875
gene id: 1276246:SCULI_RS01875
uniprot id: W6A6V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1276246:SCULI RS03670
gene id: 1276246:SCULI_RS03670
uniprot id: W6A850
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1276246:SCULI RS00125
gene id: 1276246:SCULI_RS00125
uniprot id: W6A5Z7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1276246:SCULI RS04180
gene id: 1276246:SCULI_RS04180
uniprot id: W6AHH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1276246:SCULI RS01960
gene id: 1276246:SCULI_RS01960
uniprot id: W6A6L2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1276246:SCULI RS01310
gene id: 1276246:SCULI_RS01310
uniprot id: W6AFV1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS04755
gene id: 1276246:SCULI_RS04755
uniprot id: W6A8Q4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1276246:SCULI RS01000
gene id: 1276246:SCULI_RS01000
uniprot id: W6A5W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1276246:SCULI RS04920
gene id: 1276246:SCULI_RS04920
uniprot id: W6A840
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1276246:SCULI RS04515
gene id: 1276246:SCULI_RS04515
uniprot id: W6A8E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1276246:SCULI RS00500
gene id: 1276246:SCULI_RS00500
uniprot id: W6A668
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS04435
gene id: 1276246:SCULI_RS04435
uniprot id: W6A8K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1276246:SCULI RS04855
gene id: 1276246:SCULI_RS04855
uniprot id: W6A8S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1276246:SCULI RS04490
gene id: 1276246:SCULI_RS04490
uniprot id: W6A8E5
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS02735
gene id: 1276246:SCULI_RS02735
uniprot id: W6A6W5
names: Similarity
messages: Belongs to the peptidase S66 family.

1276246:SCULI RS01295
gene id: 1276246:SCULI_RS01295
uniprot id: W6A6J0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276246:SCULI RS05240
gene id: 1276246:SCULI_RS05240
uniprot id: W6A8M2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1276246:SCULI RS05420
gene id: 1276246:SCULI_RS05420
uniprot id: W6AI71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS03220
gene id: 1276246:SCULI_RS03220
uniprot id: W6A7L3
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276246:SCULI RS00775
gene id: 1276246:SCULI_RS00775
uniprot id: W6A6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276246:SCULI RS01010
gene id: 1276246:SCULI_RS01010
uniprot id: W6A6M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1276246:SCULI RS02800
gene id: 1276246:SCULI_RS02800
uniprot id: W6A7C8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1276246:SCULI RS01050
gene id: 1276246:SCULI_RS01050
uniprot id: W6A5X6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS00210
gene id: 1276246:SCULI_RS00210
uniprot id: W6A5I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1276246:SCULI RS04210
gene id: 1276246:SCULI_RS04210
uniprot id: W6A8E9
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

1276246:SCULI RS01695
gene id: 1276246:SCULI_RS01695
uniprot id: W6A6R8
names: Subcellular Location Annotation
messages: Cytoplasm

1276246:SCULI RS04040
gene id: 1276246:SCULI_RS04040
uniprot id: W6AHF9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1276246:SCULI RS00475
gene id: 1276246:SCULI_RS00475
uniprot id: W6A663
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276246:SCULI RS01750
gene id: 1276246:SCULI_RS01750
uniprot id: W6A6Q6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1276246:SCULI RS05370
gene id: 1276246:SCULI_RS05370
uniprot id: W6A8A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1276246:SCULI RS04135
gene id: 1276246:SCULI_RS04135
uniprot id: W6A8D1
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1276246:SCULI RS00355
gene id: 1276246:SCULI_RS00355
uniprot id: W6A5Z1
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1276246:SCULI RS05055
gene id: 1276246:SCULI_RS05055
uniprot id: W6A8W2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1276246:SCULI RS01860
gene id: 1276246:SCULI_RS01860
uniprot id: W6A6J6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1276246:SCULI RS05345
gene id: 1276246:SCULI_RS05345
uniprot id: W6A8A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1276246:SCULI RS00090
gene id: 1276246:SCULI_RS00090
uniprot id: W6AFA5
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1276246:SCULI RS04510
gene id: 1276246:SCULI_RS04510
uniprot id: W6A8L4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1276246:SCULI RS01715
gene id: 1276246:SCULI_RS01715
uniprot id: W6A721
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

1276246:SCULI RS00915
gene id: 1276246:SCULI_RS00915
uniprot id: W6A6C9
names: Subcellular Location Annotation
messages: Cytoplasm

1276246:SCULI RS03245
gene id: 1276246:SCULI_RS03245
uniprot id: W6A7L7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1276246:SCULI RS01170
gene id: 1276246:SCULI_RS01170
uniprot id: W6A6G9
names: Subcellular Location Annotation
messages: Membrane

1276246:SCULI RS00320
gene id: 1276246:SCULI_RS00320
uniprot id: W6A6D2
names: Similarity
messages: Belongs to the IMPACT family.