1276221:SDIMI RS02260
gene id: 1276221:SDIMI_RS02260
uniprot id: S5LZV6
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

1276221:SDIMI RS00470
gene id: 1276221:SDIMI_RS00470
uniprot id: S5LVG8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1276221:SDIMI RS00225
gene id: 1276221:SDIMI_RS00225
uniprot id: S5MIL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1276221:SDIMI RS00980
gene id: 1276221:SDIMI_RS00980
uniprot id: S5LZ84
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS04410
gene id: 1276221:SDIMI_RS04410
uniprot id: S5MKQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

1276221:SDIMI RS01555
gene id: 1276221:SDIMI_RS01555
uniprot id: S5MJ63
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1276221:SDIMI RS03455
gene id: 1276221:SDIMI_RS03455
uniprot id: S5MF14
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

1276221:SDIMI RS04005
gene id: 1276221:SDIMI_RS04005
uniprot id: S5MFA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1276221:SDIMI RS02005
gene id: 1276221:SDIMI_RS02005
uniprot id: S5MJD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 2 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1276221:SDIMI RS03440
gene id: 1276221:SDIMI_RS03440
uniprot id: S5MK70
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276221:SDIMI RS02385
gene id: 1276221:SDIMI_RS02385
uniprot id: S5M285
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1276221:SDIMI RS01725
gene id: 1276221:SDIMI_RS01725
uniprot id: S5ME80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1276221:SDIMI RS03155
gene id: 1276221:SDIMI_RS03155
uniprot id: S5M0E4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1276221:SDIMI RS04075
gene id: 1276221:SDIMI_RS04075
uniprot id: S5M349
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1276221:SDIMI RS01320
gene id: 1276221:SDIMI_RS01320
uniprot id: S5LVU5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS03920
gene id: 1276221:SDIMI_RS03920
uniprot id: S5M311
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1276221:SDIMI RS00205
gene id: 1276221:SDIMI_RS00205
uniprot id: S5LYX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1276221:SDIMI RS04325
gene id: 1276221:SDIMI_RS04325
uniprot id: S5MFG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1276221:SDIMI RS02545
gene id: 1276221:SDIMI_RS02545
uniprot id: S5M040
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1276221:SDIMI RS01435
gene id: 1276221:SDIMI_RS01435
uniprot id: S5M1N6
names: Similarity
messages: Belongs to the DprA/Smf family.

1276221:SDIMI RS01345
gene id: 1276221:SDIMI_RS01345
uniprot id: S5LVV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1276221:SDIMI RS04015
gene id: 1276221:SDIMI_RS04015
uniprot id: S5MKH8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1276221:SDIMI RS04290
gene id: 1276221:SDIMI_RS04290
uniprot id: S5M101
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00315
gene id: 1276221:SDIMI_RS00315
uniprot id: S5MDH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1276221:SDIMI RS00490
gene id: 1276221:SDIMI_RS00490
uniprot id: S5MDK7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1276221:SDIMI RS02825
gene id: 1276221:SDIMI_RS02825
uniprot id: S5M2F1
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276221:SDIMI RS03965
gene id: 1276221:SDIMI_RS03965
uniprot id: S5M0U4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1276221:SDIMI RS01045
gene id: 1276221:SDIMI_RS01045
uniprot id: S5LVN8
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS01010
gene id: 1276221:SDIMI_RS01010
uniprot id: S5M1G9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS00575
gene id: 1276221:SDIMI_RS00575
uniprot id: S5MIR6
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1276221:SDIMI RS04380
gene id: 1276221:SDIMI_RS04380
uniprot id: S5LXM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS00340
gene id: 1276221:SDIMI_RS00340
uniprot id: S5MDH7
names: Similarity
messages: Belongs to the Lgt family.

1276221:SDIMI RS02630
gene id: 1276221:SDIMI_RS02630
uniprot id: S5MEP0
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00835
gene id: 1276221:SDIMI_RS00835
uniprot id: S5MDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1276221:SDIMI RS01100
gene id: 1276221:SDIMI_RS01100
uniprot id: S5MIZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS01025
gene id: 1276221:SDIMI_RS01025
uniprot id: S5MIY1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276221:SDIMI RS00040
gene id: 1276221:SDIMI_RS00040
uniprot id: S5M127
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1276221:SDIMI RS04210
gene id: 1276221:SDIMI_RS04210
uniprot id: S5LXI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1276221:SDIMI RS01135
gene id: 1276221:SDIMI_RS01135
uniprot id: S5M1I8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1276221:SDIMI RS03970
gene id: 1276221:SDIMI_RS03970
uniprot id: S5M325
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1276221:SDIMI RS00445
gene id: 1276221:SDIMI_RS00445
uniprot id: S5LVG3
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02035
gene id: 1276221:SDIMI_RS02035
uniprot id: S5LZR2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1276221:SDIMI RS02915
gene id: 1276221:SDIMI_RS02915
uniprot id: S5MJY9
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02245
gene id: 1276221:SDIMI_RS02245
uniprot id: S5MEG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1276221:SDIMI RS03430
gene id: 1276221:SDIMI_RS03430
uniprot id: S5MF10
names: Similarity
messages: Belongs to the CutC family.

1276221:SDIMI RS00125
gene id: 1276221:SDIMI_RS00125
uniprot id: S5LVB6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1276221:SDIMI RS00210
gene id: 1276221:SDIMI_RS00210
uniprot id: S5M148
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1276221:SDIMI RS03880
gene id: 1276221:SDIMI_RS03880
uniprot id: S5LXB6
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02605
gene id: 1276221:SDIMI_RS02605
uniprot id: S5MEN6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1276221:SDIMI RS03325
gene id: 1276221:SDIMI_RS03325
uniprot id: S5M2N3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1276221:SDIMI RS03905
gene id: 1276221:SDIMI_RS03905
uniprot id: S5LXC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1276221:SDIMI RS00170
gene id: 1276221:SDIMI_RS00170
uniprot id: S5LVC4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1276221:SDIMI RS00610
gene id: 1276221:SDIMI_RS00610
uniprot id: S5M1B0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276221:SDIMI RS02760
gene id: 1276221:SDIMI_RS02760
uniprot id: S5LWU2
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00495
gene id: 1276221:SDIMI_RS00495
uniprot id: S5LVH2
names: Subcellular Location Annotation
messages: Cytoplasm

1276221:SDIMI RS03500
gene id: 1276221:SDIMI_RS03500
uniprot id: S5M2S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1276221:SDIMI RS03810
gene id: 1276221:SDIMI_RS03810
uniprot id: S5MKD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1276221:SDIMI RS02905
gene id: 1276221:SDIMI_RS02905
uniprot id: S5MET2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276221:SDIMI RS00960
gene id: 1276221:SDIMI_RS00960
uniprot id: S5M1G0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1276221:SDIMI RS03775
gene id: 1276221:SDIMI_RS03775
uniprot id: S5LX93
names: Similarity
messages: Belongs to the Fur family.

1276221:SDIMI RS04415
gene id: 1276221:SDIMI_RS04415
uniprot id: S5M128
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1276221:SDIMI RS02975
gene id: 1276221:SDIMI_RS02975
uniprot id: S5M2H6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1276221:SDIMI RS00180
gene id: 1276221:SDIMI_RS00180
uniprot id: S5LYW7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1276221:SDIMI RS01805
gene id: 1276221:SDIMI_RS01805
uniprot id: S5ME94
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1276221:SDIMI RS02655
gene id: 1276221:SDIMI_RS02655
uniprot id: S5MEP4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1276221:SDIMI RS02165
gene id: 1276221:SDIMI_RS02165
uniprot id: S5M222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

1276221:SDIMI RS03625
gene id: 1276221:SDIMI_RS03625
uniprot id: S5M0L8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1276221:SDIMI RS04260
gene id: 1276221:SDIMI_RS04260
uniprot id: S5MKM8
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1276221:SDIMI RS00245
gene id: 1276221:SDIMI_RS00245
uniprot id: S5LVD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

1276221:SDIMI RS03280
gene id: 1276221:SDIMI_RS03280
uniprot id: S5M0G5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1276221:SDIMI RS04235
gene id: 1276221:SDIMI_RS04235
uniprot id: S5MKM4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS03480
gene id: 1276221:SDIMI_RS03480
uniprot id: S5MF16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

1276221:SDIMI RS01260
gene id: 1276221:SDIMI_RS01260
uniprot id: S5M1K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1276221:SDIMI RS03975
gene id: 1276221:SDIMI_RS03975
uniprot id: S5MFA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1276221:SDIMI RS01780
gene id: 1276221:SDIMI_RS01780
uniprot id: S5LW72
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1276221:SDIMI RS00085
gene id: 1276221:SDIMI_RS00085
uniprot id: S5LYU9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1276221:SDIMI RS00355
gene id: 1276221:SDIMI_RS00355
uniprot id: S5LZ02
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1276221:SDIMI RS04135
gene id: 1276221:SDIMI_RS04135
uniprot id: S5LXG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1276221:SDIMI RS01605
gene id: 1276221:SDIMI_RS01605
uniprot id: S5LW20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1276221:SDIMI RS01400
gene id: 1276221:SDIMI_RS01400
uniprot id: S5MJ40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1276221:SDIMI RS01305
gene id: 1276221:SDIMI_RS01305
uniprot id: S5LZD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1276221:SDIMI RS01910
gene id: 1276221:SDIMI_RS01910
uniprot id: S5MJC0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1276221:SDIMI RS03025
gene id: 1276221:SDIMI_RS03025
uniprot id: S5M2I6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1276221:SDIMI RS02820
gene id: 1276221:SDIMI_RS02820
uniprot id: S5M083
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02815
gene id: 1276221:SDIMI_RS02815
uniprot id: S5MJX2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

1276221:SDIMI RS01335
gene id: 1276221:SDIMI_RS01335
uniprot id: S5M1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1276221:SDIMI RS04125
gene id: 1276221:SDIMI_RS04125
uniprot id: S5M364
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1276221:SDIMI RS00860
gene id: 1276221:SDIMI_RS00860
uniprot id: S5MDS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1276221:SDIMI RS04300
gene id: 1276221:SDIMI_RS04300
uniprot id: S5MFG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1276221:SDIMI RS03380
gene id: 1276221:SDIMI_RS03380
uniprot id: S5MF00
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1276221:SDIMI RS02960
gene id: 1276221:SDIMI_RS02960
uniprot id: S5LWX1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1276221:SDIMI RS03855
gene id: 1276221:SDIMI_RS03855
uniprot id: S5LXA7
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS01905
gene id: 1276221:SDIMI_RS01905
uniprot id: S5LWA4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1276221:SDIMI RS03390
gene id: 1276221:SDIMI_RS03390
uniprot id: S5MK62
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1276221:SDIMI RS00390
gene id: 1276221:SDIMI_RS00390
uniprot id: S5MDI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1276221:SDIMI RS04465
gene id: 1276221:SDIMI_RS04465
uniprot id: S5MJS2
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS01065
gene id: 1276221:SDIMI_RS01065
uniprot id: S5MDV8
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS04025
gene id: 1276221:SDIMI_RS04025
uniprot id: S5M336
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1276221:SDIMI RS03265
gene id: 1276221:SDIMI_RS03265
uniprot id: S5MEY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1276221:SDIMI RS03910
gene id: 1276221:SDIMI_RS03910
uniprot id: S5MKF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1276221:SDIMI RS04340
gene id: 1276221:SDIMI_RS04340
uniprot id: S5M111
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1276221:SDIMI RS01765
gene id: 1276221:SDIMI_RS01765
uniprot id: S5LZM0
names: Similarity
messages: Belongs to the RibF family.

1276221:SDIMI RS01810
gene id: 1276221:SDIMI_RS01810
uniprot id: S5LW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

1276221:SDIMI RS00345
gene id: 1276221:SDIMI_RS00345
uniprot id: S5LVE9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

1276221:SDIMI RS00110
gene id: 1276221:SDIMI_RS00110
uniprot id: S5LYV5
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS01515
gene id: 1276221:SDIMI_RS01515
uniprot id: S5M1P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1276221:SDIMI RS02790
gene id: 1276221:SDIMI_RS02790
uniprot id: S5MJW7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1276221:SDIMI RS03950
gene id: 1276221:SDIMI_RS03950
uniprot id: S5MF95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1276221:SDIMI RS03940
gene id: 1276221:SDIMI_RS03940
uniprot id: S5M0U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1276221:SDIMI RS01695
gene id: 1276221:SDIMI_RS01695
uniprot id: S5M1T1
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS03125
gene id: 1276221:SDIMI_RS03125
uniprot id: S5M0D5
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1276221:SDIMI RS04270
gene id: 1276221:SDIMI_RS04270
uniprot id: S5M396
names: Similarity
messages: Belongs to the ParB family.

1276221:SDIMI RS03985
gene id: 1276221:SDIMI_RS03985
uniprot id: S5MKH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1276221:SDIMI RS00650
gene id: 1276221:SDIMI_RS00650
uniprot id: S5MIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1276221:SDIMI RS00975
gene id: 1276221:SDIMI_RS00975
uniprot id: S5MIX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1276221:SDIMI RS00590
gene id: 1276221:SDIMI_RS00590
uniprot id: S5MDM7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1276221:SDIMI RS04070
gene id: 1276221:SDIMI_RS04070
uniprot id: S5M0W3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1276221:SDIMI RS03235
gene id: 1276221:SDIMI_RS03235
uniprot id: S5M2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1276221:SDIMI RS03175
gene id: 1276221:SDIMI_RS03175
uniprot id: S5MK27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1276221:SDIMI RS03565
gene id: 1276221:SDIMI_RS03565
uniprot id: S5LX52
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1276221:SDIMI RS03895
gene id: 1276221:SDIMI_RS03895
uniprot id: S5M304
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1276221:SDIMI RS00420
gene id: 1276221:SDIMI_RS00420
uniprot id: S5LVG0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS04000
gene id: 1276221:SDIMI_RS04000
uniprot id: S5M330
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1276221:SDIMI RS03635
gene id: 1276221:SDIMI_RS03635
uniprot id: S5MF41
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1276221:SDIMI RS00260
gene id: 1276221:SDIMI_RS00260
uniprot id: S5M155
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1276221:SDIMI RS03205
gene id: 1276221:SDIMI_RS03205
uniprot id: S5M0F4
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00045
gene id: 1276221:SDIMI_RS00045
uniprot id: S5MDC6
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1276221:SDIMI RS04240
gene id: 1276221:SDIMI_RS04240
uniprot id: S5M0Z3
names: Similarity
messages: Belongs to the RpoE family.

1276221:SDIMI RS03875
gene id: 1276221:SDIMI_RS03875
uniprot id: S5MF82
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS00255
gene id: 1276221:SDIMI_RS00255
uniprot id: S5LYY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1276221:SDIMI RS00105
gene id: 1276221:SDIMI_RS00105
uniprot id: S5MIJ8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1276221:SDIMI RS03935
gene id: 1276221:SDIMI_RS03935
uniprot id: S5MKG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1276221:SDIMI RS04550
gene id: 1276221:SDIMI_RS04550
uniprot id: S5M0U9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1276221:SDIMI RS04255
gene id: 1276221:SDIMI_RS04255
uniprot id: S5LXJ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS00320
gene id: 1276221:SDIMI_RS00320
uniprot id: S5LVE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1276221:SDIMI RS00845
gene id: 1276221:SDIMI_RS00845
uniprot id: S5MIV0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1276221:SDIMI RS04080
gene id: 1276221:SDIMI_RS04080
uniprot id: S5MFB8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1276221:SDIMI RS03015
gene id: 1276221:SDIMI_RS03015
uniprot id: S5MK07
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1276221:SDIMI RS00020
gene id: 1276221:SDIMI_RS00020
uniprot id: S5MDC2
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

1276221:SDIMI RS01160
gene id: 1276221:SDIMI_RS01160
uniprot id: S5M1J1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1276221:SDIMI RS03180
gene id: 1276221:SDIMI_RS03180
uniprot id: S5M0E9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1276221:SDIMI RS04110
gene id: 1276221:SDIMI_RS04110
uniprot id: S5LXF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1276221:SDIMI RS03575
gene id: 1276221:SDIMI_RS03575
uniprot id: S5M0K9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1276221:SDIMI RS02890
gene id: 1276221:SDIMI_RS02890
uniprot id: S5MJY5
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1276221:SDIMI RS02175
gene id: 1276221:SDIMI_RS02175
uniprot id: S5LWH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1276221:SDIMI RS00895
gene id: 1276221:SDIMI_RS00895
uniprot id: S5LVL3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1276221:SDIMI RS01360
gene id: 1276221:SDIMI_RS01360
uniprot id: S5M1M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Cytoplasm

1276221:SDIMI RS00765
gene id: 1276221:SDIMI_RS00765
uniprot id: S5LVJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1276221:SDIMI RS03170
gene id: 1276221:SDIMI_RS03170
uniprot id: S5LWZ5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1276221:SDIMI RS04225
gene id: 1276221:SDIMI_RS04225
uniprot id: S5MFE8
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1276221:SDIMI RS00025
gene id: 1276221:SDIMI_RS00025
uniprot id: S5LV97
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS04315
gene id: 1276221:SDIMI_RS04315
uniprot id: S5M107
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1276221:SDIMI RS00465
gene id: 1276221:SDIMI_RS00465
uniprot id: S5MDK3
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276221:SDIMI RS01685
gene id: 1276221:SDIMI_RS01685
uniprot id: S5MJ83
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS03650
gene id: 1276221:SDIMI_RS03650
uniprot id: S5M0M4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1276221:SDIMI RS03845
gene id: 1276221:SDIMI_RS03845
uniprot id: S5M2Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1276221:SDIMI RS02775
gene id: 1276221:SDIMI_RS02775
uniprot id: S5M2E5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1276221:SDIMI RS02850
gene id: 1276221:SDIMI_RS02850
uniprot id: S5M2F5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1276221:SDIMI RS00010
gene id: 1276221:SDIMI_RS00010
uniprot id: S5LYT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1276221:SDIMI RS03925
gene id: 1276221:SDIMI_RS03925
uniprot id: S5MF91
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1276221:SDIMI RS02060
gene id: 1276221:SDIMI_RS02060
uniprot id: S5LZR8
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS04390
gene id: 1276221:SDIMI_RS04390
uniprot id: S5M123
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS00185
gene id: 1276221:SDIMI_RS00185
uniprot id: S5M144
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1276221:SDIMI RS02270
gene id: 1276221:SDIMI_RS02270
uniprot id: S5MEG6
names: Similarity
messages: Belongs to the TlyA family.

1276221:SDIMI RS04485
gene id: 1276221:SDIMI_RS04485
uniprot id: S5LWX3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1276221:SDIMI RS01290
gene id: 1276221:SDIMI_RS01290
uniprot id: S5ME00
names: Similarity
messages: Belongs to the peptidase M13 family.

1276221:SDIMI RS00035
gene id: 1276221:SDIMI_RS00035
uniprot id: S5LYU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1276221:SDIMI RS04420
gene id: 1276221:SDIMI_RS04420
uniprot id: S5M3C5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1276221:SDIMI RS02085
gene id: 1276221:SDIMI_RS02085
uniprot id: S5LZS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1276221:SDIMI RS03840
gene id: 1276221:SDIMI_RS03840
uniprot id: S5M0S2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1276221:SDIMI RS04375
gene id: 1276221:SDIMI_RS04375
uniprot id: S5MFH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1276221:SDIMI RS04310
gene id: 1276221:SDIMI_RS04310
uniprot id: S5MKN6
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1276221:SDIMI RS00535
gene id: 1276221:SDIMI_RS00535
uniprot id: S5M196
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276221:SDIMI RS01090
gene id: 1276221:SDIMI_RS01090
uniprot id: S5MDW4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1276221:SDIMI RS03345
gene id: 1276221:SDIMI_RS03345
uniprot id: S5M0H3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS02160
gene id: 1276221:SDIMI_RS02160
uniprot id: S5LZT6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1276221:SDIMI RS00265
gene id: 1276221:SDIMI_RS00265
uniprot id: S5MDF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1276221:SDIMI RS04185
gene id: 1276221:SDIMI_RS04185
uniprot id: S5LXH8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1276221:SDIMI RS03655
gene id: 1276221:SDIMI_RS03655
uniprot id: S5M2V3
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1276221:SDIMI RS03980
gene id: 1276221:SDIMI_RS03980
uniprot id: S5LXD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1276221:SDIMI RS04350
gene id: 1276221:SDIMI_RS04350
uniprot id: S5MFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1276221:SDIMI RS03830
gene id: 1276221:SDIMI_RS03830
uniprot id: S5LXA2
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

1276221:SDIMI RS01930
gene id: 1276221:SDIMI_RS01930
uniprot id: S5LWB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS03370
gene id: 1276221:SDIMI_RS03370
uniprot id: S5M0H8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1276221:SDIMI RS01770
gene id: 1276221:SDIMI_RS01770
uniprot id: S5M1U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1276221:SDIMI RS03495
gene id: 1276221:SDIMI_RS03495
uniprot id: S5M0J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1276221:SDIMI RS03870
gene id: 1276221:SDIMI_RS03870
uniprot id: S5M2Z9
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS01365
gene id: 1276221:SDIMI_RS01365
uniprot id: S5ME16
names: Subcellular Location Annotation
messages: Cytoplasm

1276221:SDIMI RS04280
gene id: 1276221:SDIMI_RS04280
uniprot id: S5LXK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1276221:SDIMI RS01585
gene id: 1276221:SDIMI_RS01585
uniprot id: S5MJ68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS03680
gene id: 1276221:SDIMI_RS03680
uniprot id: S5M2V9
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS03550
gene id: 1276221:SDIMI_RS03550
uniprot id: S5M0K4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1276221:SDIMI RS02250
gene id: 1276221:SDIMI_RS02250
uniprot id: S5LWI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1276221:SDIMI RS03510
gene id: 1276221:SDIMI_RS03510
uniprot id: S5LX40
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00005
gene id: 1276221:SDIMI_RS00005
uniprot id: S5MII1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1276221:SDIMI RS01005
gene id: 1276221:SDIMI_RS01005
uniprot id: S5LZ88
names: Similarity
messages: Belongs to the pyruvate kinase family.

1276221:SDIMI RS01230
gene id: 1276221:SDIMI_RS01230
uniprot id: S5LZC6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1276221:SDIMI RS04180
gene id: 1276221:SDIMI_RS04180
uniprot id: S5MFD8
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1276221:SDIMI RS01485
gene id: 1276221:SDIMI_RS01485
uniprot id: S5LZH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1276221:SDIMI RS01650
gene id: 1276221:SDIMI_RS01650
uniprot id: S5ME66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1276221:SDIMI RS00335
gene id: 1276221:SDIMI_RS00335
uniprot id: S5M165
names: Similarity
messages: Belongs to the HPrK/P family.

1276221:SDIMI RS04040
gene id: 1276221:SDIMI_RS04040
uniprot id: S5MKI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1276221:SDIMI RS00955
gene id: 1276221:SDIMI_RS00955
uniprot id: S5LZ81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1276221:SDIMI RS00220
gene id: 1276221:SDIMI_RS00220
uniprot id: S5LVD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1276221:SDIMI RS02755
gene id: 1276221:SDIMI_RS02755
uniprot id: S5MER1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276221:SDIMI RS02910
gene id: 1276221:SDIMI_RS02910
uniprot id: S5LWW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1276221:SDIMI RS00415
gene id: 1276221:SDIMI_RS00415
uniprot id: S5MDJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1276221:SDIMI RS03290
gene id: 1276221:SDIMI_RS03290
uniprot id: S5MEY7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1276221:SDIMI RS01450
gene id: 1276221:SDIMI_RS01450
uniprot id: S5MJ48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1276221:SDIMI RS04360
gene id: 1276221:SDIMI_RS04360
uniprot id: S5MKP7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1276221:SDIMI RS03255
gene id: 1276221:SDIMI_RS03255
uniprot id: S5M0G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1276221:SDIMI RS00115
gene id: 1276221:SDIMI_RS00115
uniprot id: S5M137
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1276221:SDIMI RS03820
gene id: 1276221:SDIMI_RS03820
uniprot id: S5M2Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1276221:SDIMI RS00510
gene id: 1276221:SDIMI_RS00510
uniprot id: S5M194
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1276221:SDIMI RS04085
gene id: 1276221:SDIMI_RS04085
uniprot id: S5LXF4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1276221:SDIMI RS04450
gene id: 1276221:SDIMI_RS04450
uniprot id: S5LW94
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1276221:SDIMI RS00745
gene id: 1276221:SDIMI_RS00745
uniprot id: S5MIT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

1276221:SDIMI RS03040
gene id: 1276221:SDIMI_RS03040
uniprot id: S5MK10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1276221:SDIMI RS02500
gene id: 1276221:SDIMI_RS02500
uniprot id: S5M2A9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1276221:SDIMI RS00910
gene id: 1276221:SDIMI_RS00910
uniprot id: S5M1F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1276221:SDIMI RS03580
gene id: 1276221:SDIMI_RS03580
uniprot id: S5M2T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1276221:SDIMI RS01570
gene id: 1276221:SDIMI_RS01570
uniprot id: S5ME51
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1276221:SDIMI RS00830
gene id: 1276221:SDIMI_RS00830
uniprot id: S5M1D7
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS04480
gene id: 1276221:SDIMI_RS04480
uniprot id: S5MJX5
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS04030
gene id: 1276221:SDIMI_RS04030
uniprot id: S5MFA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1276221:SDIMI RS01730
gene id: 1276221:SDIMI_RS01730
uniprot id: S5LW58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1276221:SDIMI RS04190
gene id: 1276221:SDIMI_RS04190
uniprot id: S5MKL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1276221:SDIMI RS03530
gene id: 1276221:SDIMI_RS03530
uniprot id: S5MF26
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1276221:SDIMI RS01615
gene id: 1276221:SDIMI_RS01615
uniprot id: S5LZJ2
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1276221:SDIMI RS02550
gene id: 1276221:SDIMI_RS02550
uniprot id: S5M2B5
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1276221:SDIMI RS01340
gene id: 1276221:SDIMI_RS01340
uniprot id: S5ME10
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1276221:SDIMI RS03050
gene id: 1276221:SDIMI_RS03050
uniprot id: S5M2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1276221:SDIMI RS04115
gene id: 1276221:SDIMI_RS04115
uniprot id: S5MKK0
names: Similarity
messages: Belongs to the peptidase M17 family.

1276221:SDIMI RS02530
gene id: 1276221:SDIMI_RS02530
uniprot id: S5MEM6
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00140
gene id: 1276221:SDIMI_RS00140
uniprot id: S5M138
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1276221:SDIMI RS03295
gene id: 1276221:SDIMI_RS03295
uniprot id: S5LX10
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1276221:SDIMI RS00800
gene id: 1276221:SDIMI_RS00800
uniprot id: S5LZ59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1276221:SDIMI RS02980
gene id: 1276221:SDIMI_RS02980
uniprot id: S5MEU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1276221:SDIMI RS03270
gene id: 1276221:SDIMI_RS03270
uniprot id: S5LX08
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1276221:SDIMI RS03045
gene id: 1276221:SDIMI_RS03045
uniprot id: S5M0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1276221:SDIMI RS01295
gene id: 1276221:SDIMI_RS01295
uniprot id: S5LVU0
names: Similarity
messages: Belongs to the FBPase class 2 family.

1276221:SDIMI RS00440
gene id: 1276221:SDIMI_RS00440
uniprot id: S5MDJ9
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02490
gene id: 1276221:SDIMI_RS02490
uniprot id: S5MJR2
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

1276221:SDIMI RS04335
gene id: 1276221:SDIMI_RS04335
uniprot id: S5MKP2
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.

1276221:SDIMI RS00385
gene id: 1276221:SDIMI_RS00385
uniprot id: S5M174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1276221:SDIMI RS01085
gene id: 1276221:SDIMI_RS01085
uniprot id: S5M1I0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1276221:SDIMI RS02525
gene id: 1276221:SDIMI_RS02525
uniprot id: S5M2B1
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1276221:SDIMI RS03425
gene id: 1276221:SDIMI_RS03425
uniprot id: S5M2Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1276221:SDIMI RS00175
gene id: 1276221:SDIMI_RS00175
uniprot id: S5MIK8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1276221:SDIMI RS00985
gene id: 1276221:SDIMI_RS00985
uniprot id: S5M1G4
names: Similarity
messages: Belongs to the pyruvate kinase family.

1276221:SDIMI RS03490
gene id: 1276221:SDIMI_RS03490
uniprot id: S5MK79
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1276221:SDIMI RS01875
gene id: 1276221:SDIMI_RS01875
uniprot id: S5M1W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1276221:SDIMI RS04400
gene id: 1276221:SDIMI_RS04400
uniprot id: S5MFI3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS04140
gene id: 1276221:SDIMI_RS04140
uniprot id: S5MKK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1276221:SDIMI RS01560
gene id: 1276221:SDIMI_RS01560
uniprot id: S5LZI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1276221:SDIMI RS03685
gene id: 1276221:SDIMI_RS03685
uniprot id: S5MF50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1276221:SDIMI RS03695
gene id: 1276221:SDIMI_RS03695
uniprot id: S5MKB6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1276221:SDIMI RS00395
gene id: 1276221:SDIMI_RS00395
uniprot id: S5LVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1276221:SDIMI RS00015
gene id: 1276221:SDIMI_RS00015
uniprot id: S5M124
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1276221:SDIMI RS01185
gene id: 1276221:SDIMI_RS01185
uniprot id: S5M1J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1276221:SDIMI RS04060
gene id: 1276221:SDIMI_RS04060
uniprot id: S5LXE8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1276221:SDIMI RS03460
gene id: 1276221:SDIMI_RS03460
uniprot id: S5LX31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1276221:SDIMI RS01385
gene id: 1276221:SDIMI_RS01385
uniprot id: S5M1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

1276221:SDIMI RS00970
gene id: 1276221:SDIMI_RS00970
uniprot id: S5LVM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1276221:SDIMI RS01995
gene id: 1276221:SDIMI_RS01995
uniprot id: S5MEC4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1276221:SDIMI RS01200
gene id: 1276221:SDIMI_RS01200
uniprot id: S5MJ06
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS03115
gene id: 1276221:SDIMI_RS03115
uniprot id: S5LWY7
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

1276221:SDIMI RS00090
gene id: 1276221:SDIMI_RS00090
uniprot id: S5M132
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1276221:SDIMI RS04555
gene id: 1276221:SDIMI_RS04555
uniprot id: S5M142
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1276221:SDIMI RS03700
gene id: 1276221:SDIMI_RS03700
uniprot id: S5M0P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1276221:SDIMI RS01415
gene id: 1276221:SDIMI_RS01415
uniprot id: S5ME22
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1276221:SDIMI RS00815
gene id: 1276221:SDIMI_RS00815
uniprot id: S5LVK4
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1276221:SDIMI RS01510
gene id: 1276221:SDIMI_RS01510
uniprot id: S5LZH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1276221:SDIMI RS03130
gene id: 1276221:SDIMI_RS03130
uniprot id: S5M2J7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS01440
gene id: 1276221:SDIMI_RS01440
uniprot id: S5ME27
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276221:SDIMI RS03600
gene id: 1276221:SDIMI_RS03600
uniprot id: S5M0L3
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00545
gene id: 1276221:SDIMI_RS00545
uniprot id: S5LVI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1276221:SDIMI RS02290
gene id: 1276221:SDIMI_RS02290
uniprot id: S5M250
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1276221:SDIMI RS02300
gene id: 1276221:SDIMI_RS02300
uniprot id: S5LWJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1276221:SDIMI RS03435
gene id: 1276221:SDIMI_RS03435
uniprot id: S5LX26
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1276221:SDIMI RS01410
gene id: 1276221:SDIMI_RS01410
uniprot id: S5M1N1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1276221:SDIMI RS01425
gene id: 1276221:SDIMI_RS01425
uniprot id: S5MJ43
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02365
gene id: 1276221:SDIMI_RS02365
uniprot id: S5MEI1
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS04535
gene id: 1276221:SDIMI_RS04535
uniprot id: S5LVY1
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS01125
gene id: 1276221:SDIMI_RS01125
uniprot id: S5MIZ5
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

1276221:SDIMI RS01205
gene id: 1276221:SDIMI_RS01205
uniprot id: S5LZC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1276221:SDIMI RS04250
gene id: 1276221:SDIMI_RS04250
uniprot id: S5MFF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1276221:SDIMI RS01655
gene id: 1276221:SDIMI_RS01655
uniprot id: S5LW39
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1276221:SDIMI RS01710
gene id: 1276221:SDIMI_RS01710
uniprot id: S5MJ89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1276221:SDIMI RS00350
gene id: 1276221:SDIMI_RS00350
uniprot id: S5MIN2
names: Similarity
messages: Belongs to the Lgt family.

1276221:SDIMI RS00880
gene id: 1276221:SDIMI_RS00880
uniprot id: S5M1E7
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS04095
gene id: 1276221:SDIMI_RS04095
uniprot id: S5M0W8
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

1276221:SDIMI RS03165
gene id: 1276221:SDIMI_RS03165
uniprot id: S5MEW8
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02050
gene id: 1276221:SDIMI_RS02050
uniprot id: S5LWD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1276221:SDIMI RS04020
gene id: 1276221:SDIMI_RS04020
uniprot id: S5M0V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1276221:SDIMI RS01080
gene id: 1276221:SDIMI_RS01080
uniprot id: S5LZA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1276221:SDIMI RS01880
gene id: 1276221:SDIMI_RS01880
uniprot id: S5MEA6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1276221:SDIMI RS01350
gene id: 1276221:SDIMI_RS01350
uniprot id: S5MJ31
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1276221:SDIMI RS02065
gene id: 1276221:SDIMI_RS02065
uniprot id: S5M206
names: Function
names: Similarity
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

1276221:SDIMI RS01030
gene id: 1276221:SDIMI_RS01030
uniprot id: S5LZ93
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1276221:SDIMI RS00370
gene id: 1276221:SDIMI_RS00370
uniprot id: S5LVF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1276221:SDIMI RS02955
gene id: 1276221:SDIMI_RS02955
uniprot id: S5MEU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1276221:SDIMI RS04425
gene id: 1276221:SDIMI_RS04425
uniprot id: S5MDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276221:SDIMI RS01130
gene id: 1276221:SDIMI_RS01130
uniprot id: S5LZB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1276221:SDIMI RS03825
gene id: 1276221:SDIMI_RS03825
uniprot id: S5MF71
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS00450
gene id: 1276221:SDIMI_RS00450
uniprot id: S5MIP4
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1276221:SDIMI RS00855
gene id: 1276221:SDIMI_RS00855
uniprot id: S5M1E2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS03815
gene id: 1276221:SDIMI_RS03815
uniprot id: S5M0R8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1276221:SDIMI RS03915
gene id: 1276221:SDIMI_RS03915
uniprot id: S5M0T6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1276221:SDIMI RS01015
gene id: 1276221:SDIMI_RS01015
uniprot id: S5MDU9
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS04045
gene id: 1276221:SDIMI_RS04045
uniprot id: S5M0V9
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00230
gene id: 1276221:SDIMI_RS00230
uniprot id: S5LYX9
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1276221:SDIMI RS03160
gene id: 1276221:SDIMI_RS03160
uniprot id: S5M2K0
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1276221:SDIMI RS00455
gene id: 1276221:SDIMI_RS00455
uniprot id: S5LZ17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1276221:SDIMI RS04285
gene id: 1276221:SDIMI_RS04285
uniprot id: S5MKN2
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS00505
gene id: 1276221:SDIMI_RS00505
uniprot id: S5LZ23
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1276221:SDIMI RS03715
gene id: 1276221:SDIMI_RS03715
uniprot id: S5LX83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1276221:SDIMI RS04365
gene id: 1276221:SDIMI_RS04365
uniprot id: S5M116
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1276221:SDIMI RS00150
gene id: 1276221:SDIMI_RS00150
uniprot id: S5LVC0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1276221:SDIMI RS01950
gene id: 1276221:SDIMI_RS01950
uniprot id: S5MEB8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1276221:SDIMI RS01490
gene id: 1276221:SDIMI_RS01490
uniprot id: S5M1P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1276221:SDIMI RS01180
gene id: 1276221:SDIMI_RS01180
uniprot id: S5LZB6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1276221:SDIMI RS00295
gene id: 1276221:SDIMI_RS00295
uniprot id: S5LVE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1276221:SDIMI RS03020
gene id: 1276221:SDIMI_RS03020
uniprot id: S5M0C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

1276221:SDIMI RS01390
gene id: 1276221:SDIMI_RS01390
uniprot id: S5ME18
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1276221:SDIMI RS04010
gene id: 1276221:SDIMI_RS04010
uniprot id: S5LXE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1276221:SDIMI RS02990
gene id: 1276221:SDIMI_RS02990
uniprot id: S5MK02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1276221:SDIMI RS00280
gene id: 1276221:SDIMI_RS00280
uniprot id: S5LYY7
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

1276221:SDIMI RS03675
gene id: 1276221:SDIMI_RS03675
uniprot id: S5M0M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

1276221:SDIMI RS04130
gene id: 1276221:SDIMI_RS04130
uniprot id: S5MFC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1276221:SDIMI RS03835
gene id: 1276221:SDIMI_RS03835
uniprot id: S5MKE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS01740
gene id: 1276221:SDIMI_RS01740
uniprot id: S5LZL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1276221:SDIMI RS03930
gene id: 1276221:SDIMI_RS03930
uniprot id: S5LXC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1276221:SDIMI RS04320
gene id: 1276221:SDIMI_RS04320
uniprot id: S5M3A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1276221:SDIMI RS03900
gene id: 1276221:SDIMI_RS03900
uniprot id: S5MF87
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1276221:SDIMI RS01535
gene id: 1276221:SDIMI_RS01535
uniprot id: S5LZH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1276221:SDIMI RS00680
gene id: 1276221:SDIMI_RS00680
uniprot id: S5M1C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1276221:SDIMI RS00760
gene id: 1276221:SDIMI_RS00760
uniprot id: S5MDP8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1276221:SDIMI RS03955
gene id: 1276221:SDIMI_RS03955
uniprot id: S5LXD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1276221:SDIMI RS02795
gene id: 1276221:SDIMI_RS02795
uniprot id: S5M078
names: Subcellular Location Annotation
messages: Membrane

1276221:SDIMI RS02015
gene id: 1276221:SDIMI_RS02015
uniprot id: S5M1Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1276221:SDIMI RS01565
gene id: 1276221:SDIMI_RS01565
uniprot id: S5M1Q7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1276221:SDIMI RS00235
gene id: 1276221:SDIMI_RS00235
uniprot id: S5M152
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1276221:SDIMI RS00660
gene id: 1276221:SDIMI_RS00660
uniprot id: S5M1B5
names: Similarity
messages: Belongs to the thioredoxin family.

1276221:SDIMI RS01405
gene id: 1276221:SDIMI_RS01405
uniprot id: S5LZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

1276221:SDIMI RS00120
gene id: 1276221:SDIMI_RS00120
uniprot id: S5MDD5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1276221:SDIMI RS00270
gene id: 1276221:SDIMI_RS00270
uniprot id: S5LVD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1276221:SDIMI RS02000
gene id: 1276221:SDIMI_RS02000
uniprot id: S5LWC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1276221:SDIMI RS03215
gene id: 1276221:SDIMI_RS03215
uniprot id: S5MEX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase/esterase LIP3/BchO family.
messages: Membrane

1276221:SDIMI RS00275
gene id: 1276221:SDIMI_RS00275
uniprot id: S5MIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.