1244531:CIG1485E RS05255
gene id: 1244531:CIG1485E_RS05255
uniprot id: A0A076FB41
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1244531:CIG1485E RS07295
gene id: 1244531:CIG1485E_RS07295
uniprot id: A0A076FBD3
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

1244531:CIG1485E RS00560
gene id: 1244531:CIG1485E_RS00560
uniprot id: A0A076F6Q1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1244531:CIG1485E RS05860
gene id: 1244531:CIG1485E_RS05860
uniprot id: A0A076FGR6
names: Similarity
messages: Belongs to the DprA/Smf family.

1244531:CIG1485E RS05685
gene id: 1244531:CIG1485E_RS05685
uniprot id: A0A076FGN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1244531:CIG1485E RS09445
gene id: 1244531:CIG1485E_RS09445
uniprot id: A0A076F9G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1244531:CIG1485E RS06805
gene id: 1244531:CIG1485E_RS06805
uniprot id: A0A076FBX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1244531:CIG1485E RS09305
gene id: 1244531:CIG1485E_RS09305
uniprot id: A0A076FAZ8
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS00960
gene id: 1244531:CIG1485E_RS00960
uniprot id: A0A076FE10
names: Similarity
messages: Belongs to the citrate synthase family.

1244531:CIG1485E RS06040
gene id: 1244531:CIG1485E_RS06040
uniprot id: A0A076FA15
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1244531:CIG1485E RS06600
gene id: 1244531:CIG1485E_RS06600
uniprot id: A0A076FAB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1244531:CIG1485E RS08130
gene id: 1244531:CIG1485E_RS08130
uniprot id: A0A076FB21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1244531:CIG1485E RS01695
gene id: 1244531:CIG1485E_RS01695
uniprot id: A0A076F7I1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1244531:CIG1485E RS07405
gene id: 1244531:CIG1485E_RS07405
uniprot id: A0A076FCC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

1244531:CIG1485E RS05815
gene id: 1244531:CIG1485E_RS05815
uniprot id: A0A076F9V8
names: Similarity
messages: Belongs to the aspartokinase family.

1244531:CIG1485E RS05790
gene id: 1244531:CIG1485E_RS05790
uniprot id: A0A076F9V4
names: Similarity
messages: Belongs to the TlyA family.

1244531:CIG1485E RS07730
gene id: 1244531:CIG1485E_RS07730
uniprot id: A0A076FDC4
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1244531:CIG1485E RS02660
gene id: 1244531:CIG1485E_RS02660
uniprot id: A0A076FA97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1244531:CIG1485E RS07145
gene id: 1244531:CIG1485E_RS07145
uniprot id: A0A076FB76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1244531:CIG1485E RS02665
gene id: 1244531:CIG1485E_RS02665
uniprot id: A0A076F9N7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1244531:CIG1485E RS06960
gene id: 1244531:CIG1485E_RS06960
uniprot id: A0A076FC12
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1244531:CIG1485E RS03780
gene id: 1244531:CIG1485E_RS03780
uniprot id: A0A076FFG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1244531:CIG1485E RS02700
gene id: 1244531:CIG1485E_RS02700
uniprot id: A0A076F870
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04955
gene id: 1244531:CIG1485E_RS04955
uniprot id: A0A076F9G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multiheme cytochrome c family.
messages: Binds 8 heme c groups covalently per monomer.
messages: Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.
messages: Periplasm
messages: Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process.

1244531:CIG1485E RS03040
gene id: 1244531:CIG1485E_RS03040
uniprot id: A0A076FAG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1244531:CIG1485E RS02585
gene id: 1244531:CIG1485E_RS02585
uniprot id: A0A076F8Q3
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1244531:CIG1485E RS01255
gene id: 1244531:CIG1485E_RS01255
uniprot id: A0A076F9D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1244531:CIG1485E RS00415
gene id: 1244531:CIG1485E_RS00415
uniprot id: A0A076F7F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1244531:CIG1485E RS07770
gene id: 1244531:CIG1485E_RS07770
uniprot id: A0A076FAX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS03460
gene id: 1244531:CIG1485E_RS03460
uniprot id: A0A076F8I6
names: Similarity
messages: Belongs to the hemerythrin family.

1244531:CIG1485E RS07100
gene id: 1244531:CIG1485E_RS07100
uniprot id: A0A076FCX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1244531:CIG1485E RS00350
gene id: 1244531:CIG1485E_RS00350
uniprot id: A0A076F8D7
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1244531:CIG1485E RS01785
gene id: 1244531:CIG1485E_RS01785
uniprot id: A0A076F955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1244531:CIG1485E RS02360
gene id: 1244531:CIG1485E_RS02360
uniprot id: A0A076FA46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS08315
gene id: 1244531:CIG1485E_RS08315
uniprot id: A0A076FB56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1244531:CIG1485E RS03300
gene id: 1244531:CIG1485E_RS03300
uniprot id: A0A076FF91
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1244531:CIG1485E RS02155
gene id: 1244531:CIG1485E_RS02155
uniprot id: A0A076F8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS04880
gene id: 1244531:CIG1485E_RS04880
uniprot id: A0A076F9B9
names: Similarity
messages: Belongs to the HypE family.

1244531:CIG1485E RS06120
gene id: 1244531:CIG1485E_RS06120
uniprot id: A0A076FAR7
names: Similarity
messages: Belongs to the type III secretion exporter family.

1244531:CIG1485E RS05575
gene id: 1244531:CIG1485E_RS05575
uniprot id: A0A076FC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1244531:CIG1485E RS01340
gene id: 1244531:CIG1485E_RS01340
uniprot id: A0A076FE74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1244531:CIG1485E RS08020
gene id: 1244531:CIG1485E_RS08020
uniprot id: A0A076FCR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1244531:CIG1485E RS02550
gene id: 1244531:CIG1485E_RS02550
uniprot id: A0A076FEX1
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

1244531:CIG1485E RS08220
gene id: 1244531:CIG1485E_RS08220
uniprot id: A0A076FCV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1244531:CIG1485E RS01535
gene id: 1244531:CIG1485E_RS01535
uniprot id: A0A076F904
names: Similarity
messages: Belongs to the thioredoxin family.

1244531:CIG1485E RS02870
gene id: 1244531:CIG1485E_RS02870
uniprot id: A0A076FF28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1244531:CIG1485E RS01220
gene id: 1244531:CIG1485E_RS01220
uniprot id: A0A076F768
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1244531:CIG1485E RS04310
gene id: 1244531:CIG1485E_RS04310
uniprot id: A0A076FB28
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1244531:CIG1485E RS04405
gene id: 1244531:CIG1485E_RS04405
uniprot id: A0A076F9R1
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1244531:CIG1485E RS02350
gene id: 1244531:CIG1485E_RS02350
uniprot id: A0A076F816
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

1244531:CIG1485E RS03645
gene id: 1244531:CIG1485E_RS03645
uniprot id: A0A076FA27
names: Similarity
messages: Belongs to the glutamine synthetase family.

1244531:CIG1485E RS03050
gene id: 1244531:CIG1485E_RS03050
uniprot id: A0A076FF55
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1244531:CIG1485E RS03340
gene id: 1244531:CIG1485E_RS03340
uniprot id: A0A076F944
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1244531:CIG1485E RS08275
gene id: 1244531:CIG1485E_RS08275
uniprot id: A0A076FDK2
names: Function
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

1244531:CIG1485E RS05250
gene id: 1244531:CIG1485E_RS05250
uniprot id: A0A076FBU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

1244531:CIG1485E RS02760
gene id: 1244531:CIG1485E_RS02760
uniprot id: A0A076FAB9
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS00410
gene id: 1244531:CIG1485E_RS00410
uniprot id: A0A076F6L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1244531:CIG1485E RS00195
gene id: 1244531:CIG1485E_RS00195
uniprot id: A0A076FDN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1244531:CIG1485E RS05440
gene id: 1244531:CIG1485E_RS05440
uniprot id: A0A076F9L9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS07950
gene id: 1244531:CIG1485E_RS07950
uniprot id: A0A076FAZ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1244531:CIG1485E RS01210
gene id: 1244531:CIG1485E_RS01210
uniprot id: A0A076F8T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1244531:CIG1485E RS02205
gene id: 1244531:CIG1485E_RS02205
uniprot id: A0A076F8F8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

1244531:CIG1485E RS04485
gene id: 1244531:CIG1485E_RS04485
uniprot id: A0A076FB96
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1244531:CIG1485E RS00625
gene id: 1244531:CIG1485E_RS00625
uniprot id: A0A076F8I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1244531:CIG1485E RS07430
gene id: 1244531:CIG1485E_RS07430
uniprot id: A0A076FCD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1244531:CIG1485E RS05100
gene id: 1244531:CIG1485E_RS05100
uniprot id: A0A076FGE2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1244531:CIG1485E RS05450
gene id: 1244531:CIG1485E_RS05450
uniprot id: A0A076FBY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane

1244531:CIG1485E RS08025
gene id: 1244531:CIG1485E_RS08025
uniprot id: A0A076FHZ4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1244531:CIG1485E RS01580
gene id: 1244531:CIG1485E_RS01580
uniprot id: A0A076F9J3
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1244531:CIG1485E RS01250
gene id: 1244531:CIG1485E_RS01250
uniprot id: A0A076F7U8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1244531:CIG1485E RS00530
gene id: 1244531:CIG1485E_RS00530
uniprot id: A0A076FDT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1244531:CIG1485E RS07710
gene id: 1244531:CIG1485E_RS07710
uniprot id: A0A076FCM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1244531:CIG1485E RS06430
gene id: 1244531:CIG1485E_RS06430
uniprot id: A0A076FBN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS04195
gene id: 1244531:CIG1485E_RS04195
uniprot id: A0A076F8W5
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1244531:CIG1485E RS08585
gene id: 1244531:CIG1485E_RS08585
uniprot id: A0A076FBA1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

1244531:CIG1485E RS01780
gene id: 1244531:CIG1485E_RS01780
uniprot id: A0A076F9Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1244531:CIG1485E RS02860
gene id: 1244531:CIG1485E_RS02860
uniprot id: A0A076FAE0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1244531:CIG1485E RS08365
gene id: 1244531:CIG1485E_RS08365
uniprot id: A0A076FB61
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1244531:CIG1485E RS00655
gene id: 1244531:CIG1485E_RS00655
uniprot id: A0A076FDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1244531:CIG1485E RS01965
gene id: 1244531:CIG1485E_RS01965
uniprot id: A0A076F899
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1244531:CIG1485E RS08530
gene id: 1244531:CIG1485E_RS08530
uniprot id: A0A076FI44
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1244531:CIG1485E RS05990
gene id: 1244531:CIG1485E_RS05990
uniprot id: A0A076FA03
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1244531:CIG1485E RS03575
gene id: 1244531:CIG1485E_RS03575
uniprot id: A0A076FFC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1244531:CIG1485E RS00475
gene id: 1244531:CIG1485E_RS00475
uniprot id: A0A076F8F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1244531:CIG1485E RS04365
gene id: 1244531:CIG1485E_RS04365
uniprot id: A0A076FAI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1244531:CIG1485E RS01765
gene id: 1244531:CIG1485E_RS01765
uniprot id: A0A076FEF1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1244531:CIG1485E RS06695
gene id: 1244531:CIG1485E_RS06695
uniprot id: A0A076FAY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1244531:CIG1485E RS06585
gene id: 1244531:CIG1485E_RS06585
uniprot id: A0A076FCM0
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS03010
gene id: 1244531:CIG1485E_RS03010
uniprot id: A0A076F8X5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1244531:CIG1485E RS00285
gene id: 1244531:CIG1485E_RS00285
uniprot id: A0A076F6J9
names: Similarity
messages: Belongs to the FemABX family.

1244531:CIG1485E RS02095
gene id: 1244531:CIG1485E_RS02095
uniprot id: A0A076FEL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1244531:CIG1485E RS06200
gene id: 1244531:CIG1485E_RS06200
uniprot id: A0A076FBJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS00665
gene id: 1244531:CIG1485E_RS00665
uniprot id: A0A076F7I8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1244531:CIG1485E RS08485
gene id: 1244531:CIG1485E_RS08485
uniprot id: A0A076FB81
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS01370
gene id: 1244531:CIG1485E_RS01370
uniprot id: A0A076F7A1
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01405
gene id: 1244531:CIG1485E_RS01405
uniprot id: A0A076F9G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

1244531:CIG1485E RS04630
gene id: 1244531:CIG1485E_RS04630
uniprot id: A0A076F9W2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS05900
gene id: 1244531:CIG1485E_RS05900
uniprot id: A0A076FC57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1244531:CIG1485E RS06610
gene id: 1244531:CIG1485E_RS06610
uniprot id: A0A076FAX2
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS02060
gene id: 1244531:CIG1485E_RS02060
uniprot id: A0A076F9C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS05350
gene id: 1244531:CIG1485E_RS05350
uniprot id: A0A076FB58
names: Function
names: Similarity
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Cell wall formation.

1244531:CIG1485E RS03750
gene id: 1244531:CIG1485E_RS03750
uniprot id: A0A076FA38
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1244531:CIG1485E RS00505
gene id: 1244531:CIG1485E_RS00505
uniprot id: A0A076FDS5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1244531:CIG1485E RS05650
gene id: 1244531:CIG1485E_RS05650
uniprot id: A0A076FC11
names: Similarity
messages: Belongs to the CutA family.

1244531:CIG1485E RS06390
gene id: 1244531:CIG1485E_RS06390
uniprot id: A0A076FA72
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1244531:CIG1485E RS01930
gene id: 1244531:CIG1485E_RS01930
uniprot id: A0A076FEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

1244531:CIG1485E RS06725
gene id: 1244531:CIG1485E_RS06725
uniprot id: A0A076FCP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1244531:CIG1485E RS03665
gene id: 1244531:CIG1485E_RS03665
uniprot id: A0A076FAR2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1244531:CIG1485E RS05585
gene id: 1244531:CIG1485E_RS05585
uniprot id: A0A076FGM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

1244531:CIG1485E RS01080
gene id: 1244531:CIG1485E_RS01080
uniprot id: A0A076F8Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1244531:CIG1485E RS05735
gene id: 1244531:CIG1485E_RS05735
uniprot id: A0A076FGP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1244531:CIG1485E RS06270
gene id: 1244531:CIG1485E_RS06270
uniprot id: A0A076FCF4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS05420
gene id: 1244531:CIG1485E_RS05420
uniprot id: A0A076FBX6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS00435
gene id: 1244531:CIG1485E_RS00435
uniprot id: A0A076F6M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1244531:CIG1485E RS02450
gene id: 1244531:CIG1485E_RS02450
uniprot id: A0A076FEW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1244531:CIG1485E RS03545
gene id: 1244531:CIG1485E_RS03545
uniprot id: A0A076FA13
names: Similarity
messages: Belongs to the XseB family.

1244531:CIG1485E RS05435
gene id: 1244531:CIG1485E_RS05435
uniprot id: A0A076FGJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1244531:CIG1485E RS08285
gene id: 1244531:CIG1485E_RS08285
uniprot id: A0A076FI24
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1244531:CIG1485E RS06250
gene id: 1244531:CIG1485E_RS06250
uniprot id: A0A076FBK3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS03745
gene id: 1244531:CIG1485E_RS03745
uniprot id: A0A076FAS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1244531:CIG1485E RS00480
gene id: 1244531:CIG1485E_RS00480
uniprot id: A0A076FDS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1244531:CIG1485E RS01165
gene id: 1244531:CIG1485E_RS01165
uniprot id: A0A076FE51
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1244531:CIG1485E RS05825
gene id: 1244531:CIG1485E_RS05825
uniprot id: A0A076FC43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1244531:CIG1485E RS07685
gene id: 1244531:CIG1485E_RS07685
uniprot id: A0A076FCL9
names: Similarity
messages: Belongs to the YkuD family.

1244531:CIG1485E RS05135
gene id: 1244531:CIG1485E_RS05135
uniprot id: A0A076F9I2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1244531:CIG1485E RS00910
gene id: 1244531:CIG1485E_RS00910
uniprot id: A0A076FDZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1244531:CIG1485E RS06950
gene id: 1244531:CIG1485E_RS06950
uniprot id: A0A076FB27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1244531:CIG1485E RS08525
gene id: 1244531:CIG1485E_RS08525
uniprot id: A0A076FCZ6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1244531:CIG1485E RS08215
gene id: 1244531:CIG1485E_RS08215
uniprot id: A0A076FDJ3
names: Similarity
messages: Belongs to the RecJ family.

1244531:CIG1485E RS00580
gene id: 1244531:CIG1485E_RS00580
uniprot id: A0A076FDT9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1244531:CIG1485E RS07675
gene id: 1244531:CIG1485E_RS07675
uniprot id: A0A076FBP3
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1244531:CIG1485E RS07235
gene id: 1244531:CIG1485E_RS07235
uniprot id: A0A076FHI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1244531:CIG1485E RS02605
gene id: 1244531:CIG1485E_RS02605
uniprot id: A0A076F8Q8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

1244531:CIG1485E RS01015
gene id: 1244531:CIG1485E_RS01015
uniprot id: A0A076F711
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

1244531:CIG1485E RS03700
gene id: 1244531:CIG1485E_RS03700
uniprot id: A0A076FFF0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1244531:CIG1485E RS07925
gene id: 1244531:CIG1485E_RS07925
uniprot id: A0A076FAZ0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS00660
gene id: 1244531:CIG1485E_RS00660
uniprot id: A0A076F6S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS05300
gene id: 1244531:CIG1485E_RS05300
uniprot id: A0A076FB52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1244531:CIG1485E RS00305
gene id: 1244531:CIG1485E_RS00305
uniprot id: A0A076FDP9
names: Similarity
messages: Belongs to the asparagine synthetase family.

1244531:CIG1485E RS01000
gene id: 1244531:CIG1485E_RS01000
uniprot id: A0A076F9A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

1244531:CIG1485E RS02355
gene id: 1244531:CIG1485E_RS02355
uniprot id: A0A076F8L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1244531:CIG1485E RS04270
gene id: 1244531:CIG1485E_RS04270
uniprot id: A0A076FFS0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1244531:CIG1485E RS07705
gene id: 1244531:CIG1485E_RS07705
uniprot id: A0A076FDC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1244531:CIG1485E RS06055
gene id: 1244531:CIG1485E_RS06055
uniprot id: A0A076FBH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1244531:CIG1485E RS04185
gene id: 1244531:CIG1485E_RS04185
uniprot id: A0A076FAE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1244531:CIG1485E RS06735
gene id: 1244531:CIG1485E_RS06735
uniprot id: A0A076FH67
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1244531:CIG1485E RS01895
gene id: 1244531:CIG1485E_RS01895
uniprot id: A0A076F9S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1244531:CIG1485E RS01530
gene id: 1244531:CIG1485E_RS01530
uniprot id: A0A076F9H8
names: Similarity
messages: Belongs to the UPF0102 family.

1244531:CIG1485E RS05640
gene id: 1244531:CIG1485E_RS05640
uniprot id: A0A076F9R0
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1244531:CIG1485E RS00395
gene id: 1244531:CIG1485E_RS00395
uniprot id: A0A076F928
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

1244531:CIG1485E RS03760
gene id: 1244531:CIG1485E_RS03760
uniprot id: A0A076F8N1
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

1244531:CIG1485E RS05985
gene id: 1244531:CIG1485E_RS05985
uniprot id: A0A076FGT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS00965
gene id: 1244531:CIG1485E_RS00965
uniprot id: A0A076F6Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

1244531:CIG1485E RS03330
gene id: 1244531:CIG1485E_RS03330
uniprot id: A0A076FF94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1244531:CIG1485E RS04600
gene id: 1244531:CIG1485E_RS04600
uniprot id: A0A076F951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1244531:CIG1485E RS06810
gene id: 1244531:CIG1485E_RS06810
uniprot id: A0A076FH81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1244531:CIG1485E RS03725
gene id: 1244531:CIG1485E_RS03725
uniprot id: A0A076FA36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm

1244531:CIG1485E RS05840
gene id: 1244531:CIG1485E_RS05840
uniprot id: A0A076F9W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1244531:CIG1485E RS03610
gene id: 1244531:CIG1485E_RS03610
uniprot id: A0A076F996
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

1244531:CIG1485E RS04545
gene id: 1244531:CIG1485E_RS04545
uniprot id: A0A076FFZ6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1244531:CIG1485E RS04615
gene id: 1244531:CIG1485E_RS04615
uniprot id: A0A076FAP2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1244531:CIG1485E RS09200
gene id: 1244531:CIG1485E_RS09200
uniprot id: A0A076FBG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

1244531:CIG1485E RS05565
gene id: 1244531:CIG1485E_RS05565
uniprot id: A0A076F9P6
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS03730
gene id: 1244531:CIG1485E_RS03730
uniprot id: A0A076FFF7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1244531:CIG1485E RS03890
gene id: 1244531:CIG1485E_RS03890
uniprot id: A0A076F9E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS01230
gene id: 1244531:CIG1485E_RS01230
uniprot id: A0A076F9D3
names: Similarity
messages: Belongs to the MotB family.

1244531:CIG1485E RS03445
gene id: 1244531:CIG1485E_RS03445
uniprot id: A0A076FAN1
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1244531:CIG1485E RS06635
gene id: 1244531:CIG1485E_RS06635
uniprot id: A0A076FAB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1244531:CIG1485E RS06915
gene id: 1244531:CIG1485E_RS06915
uniprot id: A0A076FHA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

1244531:CIG1485E RS05905
gene id: 1244531:CIG1485E_RS05905
uniprot id: A0A076FBF1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1244531:CIG1485E RS03425
gene id: 1244531:CIG1485E_RS03425
uniprot id: A0A076FA01
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04475
gene id: 1244531:CIG1485E_RS04475
uniprot id: A0A076F923
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1244531:CIG1485E RS03800
gene id: 1244531:CIG1485E_RS03800
uniprot id: A0A076FA61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1244531:CIG1485E RS07445
gene id: 1244531:CIG1485E_RS07445
uniprot id: A0A076FBH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1244531:CIG1485E RS01320
gene id: 1244531:CIG1485E_RS01320
uniprot id: A0A076F788
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1244531:CIG1485E RS01190
gene id: 1244531:CIG1485E_RS01190
uniprot id: A0A076FE57
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1244531:CIG1485E RS06395
gene id: 1244531:CIG1485E_RS06395
uniprot id: A0A076FAU5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1244531:CIG1485E RS01345
gene id: 1244531:CIG1485E_RS01345
uniprot id: A0A076F795
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

1244531:CIG1485E RS04275
gene id: 1244531:CIG1485E_RS04275
uniprot id: A0A076F8Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS05175
gene id: 1244531:CIG1485E_RS05175
uniprot id: A0A076FBT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1244531:CIG1485E RS08060
gene id: 1244531:CIG1485E_RS08060
uniprot id: A0A076FBV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS04160
gene id: 1244531:CIG1485E_RS04160
uniprot id: A0A076FAE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerH subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1244531:CIG1485E RS06820
gene id: 1244531:CIG1485E_RS06820
uniprot id: A0A076FB01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1244531:CIG1485E RS01690
gene id: 1244531:CIG1485E_RS01690
uniprot id: A0A076FED5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1244531:CIG1485E RS04165
gene id: 1244531:CIG1485E_RS04165
uniprot id: A0A076FFQ1
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS00400
gene id: 1244531:CIG1485E_RS00400
uniprot id: A0A076F8E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1244531:CIG1485E RS01685
gene id: 1244531:CIG1485E_RS01685
uniprot id: A0A076F937
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1244531:CIG1485E RS04115
gene id: 1244531:CIG1485E_RS04115
uniprot id: A0A076F9H9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1244531:CIG1485E RS05510
gene id: 1244531:CIG1485E_RS05510
uniprot id: A0A076FGK7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1244531:CIG1485E RS04895
gene id: 1244531:CIG1485E_RS04895
uniprot id: A0A076FAV5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

1244531:CIG1485E RS04980
gene id: 1244531:CIG1485E_RS04980
uniprot id: A0A076F9G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

1244531:CIG1485E RS08210
gene id: 1244531:CIG1485E_RS08210
uniprot id: A0A076FBY5
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS07375
gene id: 1244531:CIG1485E_RS07375
uniprot id: A0A076FD27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1244531:CIG1485E RS00970
gene id: 1244531:CIG1485E_RS00970
uniprot id: A0A076F7N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

1244531:CIG1485E RS04370
gene id: 1244531:CIG1485E_RS04370
uniprot id: A0A076FFU7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1244531:CIG1485E RS04390
gene id: 1244531:CIG1485E_RS04390
uniprot id: A0A076FAK1
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

1244531:CIG1485E RS02110
gene id: 1244531:CIG1485E_RS02110
uniprot id: A0A076F9X1
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1244531:CIG1485E RS04175
gene id: 1244531:CIG1485E_RS04175
uniprot id: A0A076F9J7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1244531:CIG1485E RS08560
gene id: 1244531:CIG1485E_RS08560
uniprot id: A0A076FB94
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1244531:CIG1485E RS00335
gene id: 1244531:CIG1485E_RS00335
uniprot id: A0A076F6K8
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1244531:CIG1485E RS06940
gene id: 1244531:CIG1485E_RS06940
uniprot id: A0A076FHA9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS01010
gene id: 1244531:CIG1485E_RS01010
uniprot id: A0A076FE20
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1244531:CIG1485E RS06555
gene id: 1244531:CIG1485E_RS06555
uniprot id: A0A076FAW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS06195
gene id: 1244531:CIG1485E_RS06195
uniprot id: A0A076FCD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS08260
gene id: 1244531:CIG1485E_RS08260
uniprot id: A0A076FI22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1244531:CIG1485E RS06300
gene id: 1244531:CIG1485E_RS06300
uniprot id: A0A076FCF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS01870
gene id: 1244531:CIG1485E_RS01870
uniprot id: A0A076F9R8
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1244531:CIG1485E RS06210
gene id: 1244531:CIG1485E_RS06210
uniprot id: A0A076FA45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1244531:CIG1485E RS06660
gene id: 1244531:CIG1485E_RS06660
uniprot id: A0A076FAC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1244531:CIG1485E RS06860
gene id: 1244531:CIG1485E_RS06860
uniprot id: A0A076FBZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1244531:CIG1485E RS01970
gene id: 1244531:CIG1485E_RS01970
uniprot id: A0A076F9T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1244531:CIG1485E RS03740
gene id: 1244531:CIG1485E_RS03740
uniprot id: A0A076F9C1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1244531:CIG1485E RS06730
gene id: 1244531:CIG1485E_RS06730
uniprot id: A0A076FBV9
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1244531:CIG1485E RS03320
gene id: 1244531:CIG1485E_RS03320
uniprot id: A0A076FAL2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS02555
gene id: 1244531:CIG1485E_RS02555
uniprot id: A0A076F848
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1244531:CIG1485E RS01850
gene id: 1244531:CIG1485E_RS01850
uniprot id: A0A076F967
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1244531:CIG1485E RS06245
gene id: 1244531:CIG1485E_RS06245
uniprot id: A0A076FCE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1244531:CIG1485E RS02565
gene id: 1244531:CIG1485E_RS02565
uniprot id: A0A076FA75
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1244531:CIG1485E RS04960
gene id: 1244531:CIG1485E_RS04960
uniprot id: A0A076FA64
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1244531:CIG1485E RS07645
gene id: 1244531:CIG1485E_RS07645
uniprot id: A0A076FAW0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1244531:CIG1485E RS04755
gene id: 1244531:CIG1485E_RS04755
uniprot id: A0A076F9Z7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1244531:CIG1485E RS03685
gene id: 1244531:CIG1485E_RS03685
uniprot id: A0A076F9B4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1244531:CIG1485E RS00460
gene id: 1244531:CIG1485E_RS00460
uniprot id: A0A076F6M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1244531:CIG1485E RS09190
gene id: 1244531:CIG1485E_RS09190
uniprot id: A0A076F906
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04890
gene id: 1244531:CIG1485E_RS04890
uniprot id: A0A076FBK4
names: Similarity
messages: Belongs to the HupF/HypC family.

1244531:CIG1485E RS09525
gene id: 1244531:CIG1485E_RS09525
uniprot id: A0A076F9Z5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1244531:CIG1485E RS00680
gene id: 1244531:CIG1485E_RS00680
uniprot id: A0A076FDV7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1244531:CIG1485E RS06620
gene id: 1244531:CIG1485E_RS06620
uniprot id: A0A076FBU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1244531:CIG1485E RS04885
gene id: 1244531:CIG1485E_RS04885
uniprot id: A0A076FA26
names: Similarity
messages: Belongs to the HypD family.

1244531:CIG1485E RS01140
gene id: 1244531:CIG1485E_RS01140
uniprot id: A0A076FE47
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1244531:CIG1485E RS01750
gene id: 1244531:CIG1485E_RS01750
uniprot id: A0A076F852
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1244531:CIG1485E RS05060
gene id: 1244531:CIG1485E_RS05060
uniprot id: A0A076FA80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1244531:CIG1485E RS02190
gene id: 1244531:CIG1485E_RS02190
uniprot id: A0A076F9F0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

1244531:CIG1485E RS02260
gene id: 1244531:CIG1485E_RS02260
uniprot id: A0A076FA37
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

1244531:CIG1485E RS03595
gene id: 1244531:CIG1485E_RS03595
uniprot id: A0A076FA19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1244531:CIG1485E RS04700
gene id: 1244531:CIG1485E_RS04700
uniprot id: A0A076F968
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1244531:CIG1485E RS07755
gene id: 1244531:CIG1485E_RS07755
uniprot id: A0A076FDC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

1244531:CIG1485E RS06325
gene id: 1244531:CIG1485E_RS06325
uniprot id: A0A076FCG4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1244531:CIG1485E RS06240
gene id: 1244531:CIG1485E_RS06240
uniprot id: A0A076FAT0
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1244531:CIG1485E RS02025
gene id: 1244531:CIG1485E_RS02025
uniprot id: A0A076F9V3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1244531:CIG1485E RS05115
gene id: 1244531:CIG1485E_RS05115
uniprot id: A0A076FA88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1244531:CIG1485E RS03420
gene id: 1244531:CIG1485E_RS03420
uniprot id: A0A076FAM8
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS07365
gene id: 1244531:CIG1485E_RS07365
uniprot id: A0A076FAQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS02440
gene id: 1244531:CIG1485E_RS02440
uniprot id: A0A076FA52
names: Similarity
messages: Belongs to the IMPACT family.

1244531:CIG1485E RS03365
gene id: 1244531:CIG1485E_RS03365
uniprot id: A0A076F952
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1244531:CIG1485E RS01400
gene id: 1244531:CIG1485E_RS01400
uniprot id: A0A076F7Y2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

1244531:CIG1485E RS03925
gene id: 1244531:CIG1485E_RS03925
uniprot id: A0A076FA93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1244531:CIG1485E RS05460
gene id: 1244531:CIG1485E_RS05460
uniprot id: A0A076FGJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1244531:CIG1485E RS04915
gene id: 1244531:CIG1485E_RS04915
uniprot id: A0A076FBN4
names: Similarity
messages: Belongs to the peptidase A31 family.

1244531:CIG1485E RS07220
gene id: 1244531:CIG1485E_RS07220
uniprot id: A0A076FB97
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01410
gene id: 1244531:CIG1485E_RS01410
uniprot id: A0A076F8X9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1244531:CIG1485E RS07190
gene id: 1244531:CIG1485E_RS07190
uniprot id: A0A076FAL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1244531:CIG1485E RS07750
gene id: 1244531:CIG1485E_RS07750
uniprot id: A0A076FBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1244531:CIG1485E RS02170
gene id: 1244531:CIG1485E_RS02170
uniprot id: A0A076FEM5
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1244531:CIG1485E RS05315
gene id: 1244531:CIG1485E_RS05315
uniprot id: A0A076FAB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1244531:CIG1485E RS04875
gene id: 1244531:CIG1485E_RS04875
uniprot id: A0A076FG81
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1244531:CIG1485E RS04635
gene id: 1244531:CIG1485E_RS04635
uniprot id: A0A076FBD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1244531:CIG1485E RS07970
gene id: 1244531:CIG1485E_RS07970
uniprot id: A0A076FHY7
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.

1244531:CIG1485E RS00010
gene id: 1244531:CIG1485E_RS00010
uniprot id: A0A076F8W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1244531:CIG1485E RS06745
gene id: 1244531:CIG1485E_RS06745
uniprot id: A0A076FAY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS03535
gene id: 1244531:CIG1485E_RS03535
uniprot id: A0A076F976
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1244531:CIG1485E RS07845
gene id: 1244531:CIG1485E_RS07845
uniprot id: A0A076FAY5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1244531:CIG1485E RS01630
gene id: 1244531:CIG1485E_RS01630
uniprot id: A0A076F9L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1244531:CIG1485E RS00125
gene id: 1244531:CIG1485E_RS00125
uniprot id: A0A076F6H3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1244531:CIG1485E RS02510
gene id: 1244531:CIG1485E_RS02510
uniprot id: A0A076F8N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

1244531:CIG1485E RS03765
gene id: 1244531:CIG1485E_RS03765
uniprot id: A0A076F9C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1244531:CIG1485E RS03020
gene id: 1244531:CIG1485E_RS03020
uniprot id: A0A076F9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1244531:CIG1485E RS07605
gene id: 1244531:CIG1485E_RS07605
uniprot id: A0A076FDA7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1244531:CIG1485E RS02340
gene id: 1244531:CIG1485E_RS02340
uniprot id: A0A076F9J2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS06180
gene id: 1244531:CIG1485E_RS06180
uniprot id: A0A076FGX6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

1244531:CIG1485E RS07350
gene id: 1244531:CIG1485E_RS07350
uniprot id: A0A076FD22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1244531:CIG1485E RS06840
gene id: 1244531:CIG1485E_RS06840
uniprot id: A0A076FAE8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1244531:CIG1485E RS02050
gene id: 1244531:CIG1485E_RS02050
uniprot id: A0A076F8C1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS07115
gene id: 1244531:CIG1485E_RS07115
uniprot id: A0A076FAJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1244531:CIG1485E RS02130
gene id: 1244531:CIG1485E_RS02130
uniprot id: A0A076F8E0
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS05830
gene id: 1244531:CIG1485E_RS05830
uniprot id: A0A076FBE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1244531:CIG1485E RS06525
gene id: 1244531:CIG1485E_RS06525
uniprot id: A0A076FCK8
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1244531:CIG1485E RS01900
gene id: 1244531:CIG1485E_RS01900
uniprot id: A0A076F984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1244531:CIG1485E RS07165
gene id: 1244531:CIG1485E_RS07165
uniprot id: A0A076FAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1244531:CIG1485E RS04540
gene id: 1244531:CIG1485E_RS04540
uniprot id: A0A076FAM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1244531:CIG1485E RS06435
gene id: 1244531:CIG1485E_RS06435
uniprot id: A0A076FH20
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01145
gene id: 1244531:CIG1485E_RS01145
uniprot id: A0A076F747
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1244531:CIG1485E RS02300
gene id: 1244531:CIG1485E_RS02300
uniprot id: A0A076F811
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS06850
gene id: 1244531:CIG1485E_RS06850
uniprot id: A0A076FB06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1244531:CIG1485E RS02885
gene id: 1244531:CIG1485E_RS02885
uniprot id: A0A076FAE5
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

1244531:CIG1485E RS05260
gene id: 1244531:CIG1485E_RS05260
uniprot id: A0A076FGH0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1244531:CIG1485E RS02430
gene id: 1244531:CIG1485E_RS02430
uniprot id: A0A076F828
names: Function
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.

1244531:CIG1485E RS05310
gene id: 1244531:CIG1485E_RS05310
uniprot id: A0A076F9K1
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1244531:CIG1485E RS04200
gene id: 1244531:CIG1485E_RS04200
uniprot id: A0A076F9K6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS04920
gene id: 1244531:CIG1485E_RS04920
uniprot id: A0A076FAZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

1244531:CIG1485E RS07635
gene id: 1244531:CIG1485E_RS07635
uniprot id: A0A076FCL0
names: Similarity
messages: Belongs to the UPF0763 family.

1244531:CIG1485E RS05050
gene id: 1244531:CIG1485E_RS05050
uniprot id: A0A076FGD3
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1244531:CIG1485E RS07435
gene id: 1244531:CIG1485E_RS07435
uniprot id: A0A076FHN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS06910
gene id: 1244531:CIG1485E_RS06910
uniprot id: A0A076FC02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

1244531:CIG1485E RS05040
gene id: 1244531:CIG1485E_RS05040
uniprot id: A0A076FBR1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1244531:CIG1485E RS02830
gene id: 1244531:CIG1485E_RS02830
uniprot id: A0A076F8U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1244531:CIG1485E RS04995
gene id: 1244531:CIG1485E_RS04995
uniprot id: A0A076FAZ9
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS03175
gene id: 1244531:CIG1485E_RS03175
uniprot id: A0A076F9W9
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS08575
gene id: 1244531:CIG1485E_RS08575
uniprot id: A0A076FD03
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1244531:CIG1485E RS03905
gene id: 1244531:CIG1485E_RS03905
uniprot id: A0A076FFJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

1244531:CIG1485E RS06310
gene id: 1244531:CIG1485E_RS06310
uniprot id: A0A076FGZ8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1244531:CIG1485E RS05230
gene id: 1244531:CIG1485E_RS05230
uniprot id: A0A076FB36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1244531:CIG1485E RS05020
gene id: 1244531:CIG1485E_RS05020
uniprot id: A0A076FB03
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1244531:CIG1485E RS03630
gene id: 1244531:CIG1485E_RS03630
uniprot id: A0A076F8K8
names: Similarity
messages: Belongs to the peptidase M16 family.

1244531:CIG1485E RS05550
gene id: 1244531:CIG1485E_RS05550
uniprot id: A0A076FBZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

1244531:CIG1485E RS00570
gene id: 1244531:CIG1485E_RS00570
uniprot id: A0A076F964
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1244531:CIG1485E RS08115
gene id: 1244531:CIG1485E_RS08115
uniprot id: A0A076FBW7
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1244531:CIG1485E RS00915
gene id: 1244531:CIG1485E_RS00915
uniprot id: A0A076F6X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1244531:CIG1485E RS06765
gene id: 1244531:CIG1485E_RS06765
uniprot id: A0A076FAD3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1244531:CIG1485E RS07655
gene id: 1244531:CIG1485E_RS07655
uniprot id: A0A076FDB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

1244531:CIG1485E RS03640
gene id: 1244531:CIG1485E_RS03640
uniprot id: A0A076FAQ7
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1244531:CIG1485E RS04705
gene id: 1244531:CIG1485E_RS04705
uniprot id: A0A076F9Y2
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04685
gene id: 1244531:CIG1485E_RS04685
uniprot id: A0A076FBF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1244531:CIG1485E RS06870
gene id: 1244531:CIG1485E_RS06870
uniprot id: A0A076FAF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1244531:CIG1485E RS00720
gene id: 1244531:CIG1485E_RS00720
uniprot id: A0A076F980
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS07250
gene id: 1244531:CIG1485E_RS07250
uniprot id: A0A076FD04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1244531:CIG1485E RS06885
gene id: 1244531:CIG1485E_RS06885
uniprot id: A0A076FBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1244531:CIG1485E RS05140
gene id: 1244531:CIG1485E_RS05140
uniprot id: A0A076FA90
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1244531:CIG1485E RS07600
gene id: 1244531:CIG1485E_RS07600
uniprot id: A0A076FBN0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS08885
gene id: 1244531:CIG1485E_RS08885
uniprot id: A0A076FCD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

1244531:CIG1485E RS07340
gene id: 1244531:CIG1485E_RS07340
uniprot id: A0A076FAQ0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1244531:CIG1485E RS01540
gene id: 1244531:CIG1485E_RS01540
uniprot id: A0A076FEA3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1244531:CIG1485E RS06650
gene id: 1244531:CIG1485E_RS06650
uniprot id: A0A076FBU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1244531:CIG1485E RS02465
gene id: 1244531:CIG1485E_RS02465
uniprot id: A0A076FA56
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS01305
gene id: 1244531:CIG1485E_RS01305
uniprot id: A0A076F9E3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1244531:CIG1485E RS08605
gene id: 1244531:CIG1485E_RS08605
uniprot id: A0A076FD06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1244531:CIG1485E RS00380
gene id: 1244531:CIG1485E_RS00380
uniprot id: A0A076FDQ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1244531:CIG1485E RS02635
gene id: 1244531:CIG1485E_RS02635
uniprot id: A0A076FA91
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1244531:CIG1485E RS02245
gene id: 1244531:CIG1485E_RS02245
uniprot id: A0A076FEN4
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1244531:CIG1485E RS01385
gene id: 1244531:CIG1485E_RS01385
uniprot id: A0A076F8X3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS03160
gene id: 1244531:CIG1485E_RS03160
uniprot id: A0A076F8E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1244531:CIG1485E RS07670
gene id: 1244531:CIG1485E_RS07670
uniprot id: A0A076FAW4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS04925
gene id: 1244531:CIG1485E_RS04925
uniprot id: A0A076FGA2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1244531:CIG1485E RS06750
gene id: 1244531:CIG1485E_RS06750
uniprot id: A0A076FCP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1244531:CIG1485E RS03615
gene id: 1244531:CIG1485E_RS03615
uniprot id: A0A076FAQ4
names: Similarity
messages: Belongs to the MQO family.

1244531:CIG1485E RS00200
gene id: 1244531:CIG1485E_RS00200
uniprot id: A0A076F6I6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1244531:CIG1485E RS06645
gene id: 1244531:CIG1485E_RS06645
uniprot id: A0A076FCN1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1244531:CIG1485E RS07160
gene id: 1244531:CIG1485E_RS07160
uniprot id: A0A076FHH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS01865
gene id: 1244531:CIG1485E_RS01865
uniprot id: A0A076F874
names: Similarity
messages: Belongs to the PhzF family.

1244531:CIG1485E RS02600
gene id: 1244531:CIG1485E_RS02600
uniprot id: A0A076F855
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1244531:CIG1485E RS00885
gene id: 1244531:CIG1485E_RS00885
uniprot id: A0A076FDZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1244531:CIG1485E RS01745
gene id: 1244531:CIG1485E_RS01745
uniprot id: A0A076F7J1
names: Similarity
messages: Belongs to the GSP E family.

1244531:CIG1485E RS02610
gene id: 1244531:CIG1485E_RS02610
uniprot id: A0A076FA85
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1244531:CIG1485E RS06995
gene id: 1244531:CIG1485E_RS06995
uniprot id: A0A076FAG9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1244531:CIG1485E RS00895
gene id: 1244531:CIG1485E_RS00895
uniprot id: A0A076F7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1244531:CIG1485E RS03070
gene id: 1244531:CIG1485E_RS03070
uniprot id: A0A076F9V1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1244531:CIG1485E RS00445
gene id: 1244531:CIG1485E_RS00445
uniprot id: A0A076F939
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1244531:CIG1485E RS02400
gene id: 1244531:CIG1485E_RS02400
uniprot id: A0A076F826
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS00535
gene id: 1244531:CIG1485E_RS00535
uniprot id: A0A076F6P5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1244531:CIG1485E RS04360
gene id: 1244531:CIG1485E_RS04360
uniprot id: A0A076FB38
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS07805
gene id: 1244531:CIG1485E_RS07805
uniprot id: A0A076FDD1
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS04490
gene id: 1244531:CIG1485E_RS04490
uniprot id: A0A076FAM0
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS05690
gene id: 1244531:CIG1485E_RS05690
uniprot id: A0A076F9T0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1244531:CIG1485E RS07225
gene id: 1244531:CIG1485E_RS07225
uniprot id: A0A076FD00
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1244531:CIG1485E RS02575
gene id: 1244531:CIG1485E_RS02575
uniprot id: A0A076FEX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS04280
gene id: 1244531:CIG1485E_RS04280
uniprot id: A0A076F9M5
names: Similarity
messages: Belongs to the peptidase C40 family.

1244531:CIG1485E RS03540
gene id: 1244531:CIG1485E_RS03540
uniprot id: A0A076FAP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1244531:CIG1485E RS06440
gene id: 1244531:CIG1485E_RS06440
uniprot id: A0A076FA82
names: Similarity
messages: Belongs to the GARS family.

1244531:CIG1485E RS03695
gene id: 1244531:CIG1485E_RS03695
uniprot id: A0A076FA33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1244531:CIG1485E RS01440
gene id: 1244531:CIG1485E_RS01440
uniprot id: A0A076FE85
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1244531:CIG1485E RS07960
gene id: 1244531:CIG1485E_RS07960
uniprot id: A0A076FDE9
names: Subcellular Location Annotation
messages: Cytoplasm

1244531:CIG1485E RS05325
gene id: 1244531:CIG1485E_RS05325
uniprot id: A0A076FB55
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1244531:CIG1485E RS04000
gene id: 1244531:CIG1485E_RS04000
uniprot id: A0A076F9F8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS01390
gene id: 1244531:CIG1485E_RS01390
uniprot id: A0A076FE79
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1244531:CIG1485E RS01225
gene id: 1244531:CIG1485E_RS01225
uniprot id: A0A076F7U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS08570
gene id: 1244531:CIG1485E_RS08570
uniprot id: A0A076FDP8
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1244531:CIG1485E RS07120
gene id: 1244531:CIG1485E_RS07120
uniprot id: A0A076FB72
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1244531:CIG1485E RS03245
gene id: 1244531:CIG1485E_RS03245
uniprot id: A0A076FAK3
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1244531:CIG1485E RS08405
gene id: 1244531:CIG1485E_RS08405
uniprot id: A0A076FCX7
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1244531:CIG1485E RS02455
gene id: 1244531:CIG1485E_RS02455
uniprot id: A0A076F833
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dps family.
messages: Cytoplasm

1244531:CIG1485E RS01740
gene id: 1244531:CIG1485E_RS01740
uniprot id: A0A076FEE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1244531:CIG1485E RS05895
gene id: 1244531:CIG1485E_RS05895
uniprot id: A0A076FAL8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS00900
gene id: 1244531:CIG1485E_RS00900
uniprot id: A0A076F993
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1244531:CIG1485E RS07580
gene id: 1244531:CIG1485E_RS07580
uniprot id: A0A076FDA3
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1244531:CIG1485E RS00935
gene id: 1244531:CIG1485E_RS00935
uniprot id: A0A076FE05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

1244531:CIG1485E RS01325
gene id: 1244531:CIG1485E_RS01325
uniprot id: A0A076F7W6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1244531:CIG1485E RS06420
gene id: 1244531:CIG1485E_RS06420
uniprot id: A0A076FAU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1244531:CIG1485E RS00005
gene id: 1244531:CIG1485E_RS00005
uniprot id: A0A076F784
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1244531:CIG1485E RS05160
gene id: 1244531:CIG1485E_RS05160
uniprot id: A0A076FGF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1244531:CIG1485E RS01495
gene id: 1244531:CIG1485E_RS01495
uniprot id: A0A076F7C9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1244531:CIG1485E RS01270
gene id: 1244531:CIG1485E_RS01270
uniprot id: A0A076F778
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1244531:CIG1485E RS03285
gene id: 1244531:CIG1485E_RS03285
uniprot id: A0A076F934
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS07140
gene id: 1244531:CIG1485E_RS07140
uniprot id: A0A076FAK2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1244531:CIG1485E RS04250
gene id: 1244531:CIG1485E_RS04250
uniprot id: A0A076F9L8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1244531:CIG1485E RS01840
gene id: 1244531:CIG1485E_RS01840
uniprot id: A0A076F869
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1244531:CIG1485E RS02320
gene id: 1244531:CIG1485E_RS02320
uniprot id: A0A076FEU1
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01880
gene id: 1244531:CIG1485E_RS01880
uniprot id: A0A076FEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1244531:CIG1485E RS09420
gene id: 1244531:CIG1485E_RS09420
uniprot id: A0A076FBZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS06050
gene id: 1244531:CIG1485E_RS06050
uniprot id: A0A076FC91
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1244531:CIG1485E RS00975
gene id: 1244531:CIG1485E_RS00975
uniprot id: A0A076F9A0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1244531:CIG1485E RS00765
gene id: 1244531:CIG1485E_RS00765
uniprot id: A0A076F7K2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1244531:CIG1485E RS08380
gene id: 1244531:CIG1485E_RS08380
uniprot id: A0A076FCX5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1244531:CIG1485E RS07560
gene id: 1244531:CIG1485E_RS07560
uniprot id: A0A076FCJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1244531:CIG1485E RS03880
gene id: 1244531:CIG1485E_RS03880
uniprot id: A0A076FFI9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1244531:CIG1485E RS05150
gene id: 1244531:CIG1485E_RS05150
uniprot id: A0A076FB24
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1244531:CIG1485E RS07650
gene id: 1244531:CIG1485E_RS07650
uniprot id: A0A076FBP0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1244531:CIG1485E RS06010
gene id: 1244531:CIG1485E_RS06010
uniprot id: A0A076FGT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

1244531:CIG1485E RS04325
gene id: 1244531:CIG1485E_RS04325
uniprot id: A0A076F8Z6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1244531:CIG1485E RS01960
gene id: 1244531:CIG1485E_RS01960
uniprot id: A0A076F7P0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1244531:CIG1485E RS01830
gene id: 1244531:CIG1485E_RS01830
uniprot id: A0A076FEG0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS07740
gene id: 1244531:CIG1485E_RS07740
uniprot id: A0A076FHV2
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS03240
gene id: 1244531:CIG1485E_RS03240
uniprot id: A0A076F930
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1244531:CIG1485E RS01060
gene id: 1244531:CIG1485E_RS01060
uniprot id: A0A076FE33
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1244531:CIG1485E RS08295
gene id: 1244531:CIG1485E_RS08295
uniprot id: A0A076FC01
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS00495
gene id: 1244531:CIG1485E_RS00495
uniprot id: A0A076F949
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1244531:CIG1485E RS09195
gene id: 1244531:CIG1485E_RS09195
uniprot id: A0A076FBB3
names: Similarity
messages: Belongs to the DEAD box helicase family.

1244531:CIG1485E RS07945
gene id: 1244531:CIG1485E_RS07945
uniprot id: A0A076FHY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1244531:CIG1485E RS01635
gene id: 1244531:CIG1485E_RS01635
uniprot id: A0A076F924
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1244531:CIG1485E RS05890
gene id: 1244531:CIG1485E_RS05890
uniprot id: A0A076F9X4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1244531:CIG1485E RS03895
gene id: 1244531:CIG1485E_RS03895
uniprot id: A0A076FAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS07955
gene id: 1244531:CIG1485E_RS07955
uniprot id: A0A076FBU0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1244531:CIG1485E RS05345
gene id: 1244531:CIG1485E_RS05345
uniprot id: A0A076FBW5
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1244531:CIG1485E RS06875
gene id: 1244531:CIG1485E_RS06875
uniprot id: A0A076FB12
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1244531:CIG1485E RS05070
gene id: 1244531:CIG1485E_RS05070
uniprot id: A0A076FB10
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1244531:CIG1485E RS01005
gene id: 1244531:CIG1485E_RS01005
uniprot id: A0A076F8P6
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS00420
gene id: 1244531:CIG1485E_RS00420
uniprot id: A0A076F933
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1244531:CIG1485E RS00065
gene id: 1244531:CIG1485E_RS00065
uniprot id: A0A076F888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS04155
gene id: 1244531:CIG1485E_RS04155
uniprot id: A0A076FB04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1244531:CIG1485E RS04205
gene id: 1244531:CIG1485E_RS04205
uniprot id: A0A076FB11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1244531:CIG1485E RS04795
gene id: 1244531:CIG1485E_RS04795
uniprot id: A0A076FG58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1244531:CIG1485E RS04430
gene id: 1244531:CIG1485E_RS04430
uniprot id: A0A076F9R5
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

1244531:CIG1485E RS03345
gene id: 1244531:CIG1485E_RS03345
uniprot id: A0A076FAL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1244531:CIG1485E RS01380
gene id: 1244531:CIG1485E_RS01380
uniprot id: A0A076F9F6
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS03005
gene id: 1244531:CIG1485E_RS03005
uniprot id: A0A076F8B3
names: Similarity
messages: Belongs to the P(II) protein family.

1244531:CIG1485E RS06785
gene id: 1244531:CIG1485E_RS06785
uniprot id: A0A076FH76
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1244531:CIG1485E RS01195
gene id: 1244531:CIG1485E_RS01195
uniprot id: A0A076F760
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1244531:CIG1485E RS00635
gene id: 1244531:CIG1485E_RS00635
uniprot id: A0A076F6R7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1244531:CIG1485E RS00815
gene id: 1244531:CIG1485E_RS00815
uniprot id: A0A076FDY1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1244531:CIG1485E RS04170
gene id: 1244531:CIG1485E_RS04170
uniprot id: A0A076F8W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS07155
gene id: 1244531:CIG1485E_RS07155
uniprot id: A0A076FC55
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1244531:CIG1485E RS01640
gene id: 1244531:CIG1485E_RS01640
uniprot id: A0A076FEC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1244531:CIG1485E RS04525
gene id: 1244531:CIG1485E_RS04525
uniprot id: A0A076F935
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

1244531:CIG1485E RS02470
gene id: 1244531:CIG1485E_RS02470
uniprot id: A0A076F9K7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS06760
gene id: 1244531:CIG1485E_RS06760
uniprot id: A0A076FH71
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1244531:CIG1485E RS07725
gene id: 1244531:CIG1485E_RS07725
uniprot id: A0A076FBQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

1244531:CIG1485E RS00390
gene id: 1244531:CIG1485E_RS00390
uniprot id: A0A076F7F0
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1244531:CIG1485E RS00325
gene id: 1244531:CIG1485E_RS00325
uniprot id: A0A076F8D2
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1244531:CIG1485E RS08500
gene id: 1244531:CIG1485E_RS08500
uniprot id: A0A076FCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

1244531:CIG1485E RS06825
gene id: 1244531:CIG1485E_RS06825
uniprot id: A0A076FCR3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1244531:CIG1485E RS04240
gene id: 1244531:CIG1485E_RS04240
uniprot id: A0A076FFR5
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

1244531:CIG1485E RS07745
gene id: 1244531:CIG1485E_RS07745
uniprot id: A0A076FAX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1244531:CIG1485E RS03025
gene id: 1244531:CIG1485E_RS03025
uniprot id: A0A076FF50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1244531:CIG1485E RS03440
gene id: 1244531:CIG1485E_RS03440
uniprot id: A0A076F965
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1244531:CIG1485E RS04970
gene id: 1244531:CIG1485E_RS04970
uniprot id: A0A076FAZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1244531:CIG1485E RS02620
gene id: 1244531:CIG1485E_RS02620
uniprot id: A0A076FEY4
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.

1244531:CIG1485E RS01335
gene id: 1244531:CIG1485E_RS01335
uniprot id: A0A076F8W1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS01975
gene id: 1244531:CIG1485E_RS01975
uniprot id: A0A076F9A6
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

1244531:CIG1485E RS02590
gene id: 1244531:CIG1485E_RS02590
uniprot id: A0A076F9M4
names: Similarity
messages: Belongs to the UPF0751 family.

1244531:CIG1485E RS08105
gene id: 1244531:CIG1485E_RS08105
uniprot id: A0A076FI05
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

1244531:CIG1485E RS06615
gene id: 1244531:CIG1485E_RS06615
uniprot id: A0A076FCM6
names: Similarity
messages: Belongs to the FeoA family.

1244531:CIG1485E RS01455
gene id: 1244531:CIG1485E_RS01455
uniprot id: A0A076F9G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1244531:CIG1485E RS06540
gene id: 1244531:CIG1485E_RS06540
uniprot id: A0A076FAA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1244531:CIG1485E RS05870
gene id: 1244531:CIG1485E_RS05870
uniprot id: A0A076FAL4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS05275
gene id: 1244531:CIG1485E_RS05275
uniprot id: A0A076FB47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

1244531:CIG1485E RS05030
gene id: 1244531:CIG1485E_RS05030
uniprot id: A0A076F9H3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1244531:CIG1485E RS00015
gene id: 1244531:CIG1485E_RS00015
uniprot id: A0A076F879
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1244531:CIG1485E RS06190
gene id: 1244531:CIG1485E_RS06190
uniprot id: A0A076FAS7
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1244531:CIG1485E RS01415
gene id: 1244531:CIG1485E_RS01415
uniprot id: A0A076FE83
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1244531:CIG1485E RS05075
gene id: 1244531:CIG1485E_RS05075
uniprot id: A0A076FGD8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1244531:CIG1485E RS07130
gene id: 1244531:CIG1485E_RS07130
uniprot id: A0A076FC47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS05305
gene id: 1244531:CIG1485E_RS05305
uniprot id: A0A076FGH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1244531:CIG1485E RS05170
gene id: 1244531:CIG1485E_RS05170
uniprot id: A0A076FA95
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1244531:CIG1485E RS06455
gene id: 1244531:CIG1485E_RS06455
uniprot id: A0A076FBP2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1244531:CIG1485E RS04820
gene id: 1244531:CIG1485E_RS04820
uniprot id: A0A076FG65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

1244531:CIG1485E RS00465
gene id: 1244531:CIG1485E_RS00465
uniprot id: A0A076F7G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1244531:CIG1485E RS07530
gene id: 1244531:CIG1485E_RS07530
uniprot id: A0A076FD95
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1244531:CIG1485E RS06990
gene id: 1244531:CIG1485E_RS06990
uniprot id: A0A076FHC3
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS05265
gene id: 1244531:CIG1485E_RS05265
uniprot id: A0A076F9J5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1244531:CIG1485E RS00520
gene id: 1244531:CIG1485E_RS00520
uniprot id: A0A076F953
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1244531:CIG1485E RS06330
gene id: 1244531:CIG1485E_RS06330
uniprot id: A0A076FBL8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS01735
gene id: 1244531:CIG1485E_RS01735
uniprot id: A0A076F943
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1244531:CIG1485E RS05780
gene id: 1244531:CIG1485E_RS05780
uniprot id: A0A076FBD5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS04560
gene id: 1244531:CIG1485E_RS04560
uniprot id: A0A076FBB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS07965
gene id: 1244531:CIG1485E_RS07965
uniprot id: A0A076FCQ9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1244531:CIG1485E RS06655
gene id: 1244531:CIG1485E_RS06655
uniprot id: A0A076FH56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1244531:CIG1485E RS05570
gene id: 1244531:CIG1485E_RS05570
uniprot id: A0A076FAG3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1244531:CIG1485E RS07595
gene id: 1244531:CIG1485E_RS07595
uniprot id: A0A076FAV3
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1244531:CIG1485E RS06290
gene id: 1244531:CIG1485E_RS06290
uniprot id: A0A076FAT5
names: Similarity
messages: Belongs to the SCO1/2 family.

1244531:CIG1485E RS00870
gene id: 1244531:CIG1485E_RS00870
uniprot id: A0A076F7L3
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1244531:CIG1485E RS01655
gene id: 1244531:CIG1485E_RS01655
uniprot id: A0A076F9L7
names: Similarity
messages: Belongs to the NadC/ModD family.

1244531:CIG1485E RS00555
gene id: 1244531:CIG1485E_RS00555
uniprot id: A0A076FDT4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS07385
gene id: 1244531:CIG1485E_RS07385
uniprot id: A0A076FHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1244531:CIG1485E RS01135
gene id: 1244531:CIG1485E_RS01135
uniprot id: A0A076F8S0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1244531:CIG1485E RS05470
gene id: 1244531:CIG1485E_RS05470
uniprot id: A0A076FAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1244531:CIG1485E RS07290
gene id: 1244531:CIG1485E_RS07290
uniprot id: A0A076FAN8
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1244531:CIG1485E RS00425
gene id: 1244531:CIG1485E_RS00425
uniprot id: A0A076F8E8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1244531:CIG1485E RS08535
gene id: 1244531:CIG1485E_RS08535
uniprot id: A0A076FB90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1244531:CIG1485E RS05505
gene id: 1244531:CIG1485E_RS05505
uniprot id: A0A076FB83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1244531:CIG1485E RS07195
gene id: 1244531:CIG1485E_RS07195
uniprot id: A0A076FB89
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1244531:CIG1485E RS05130
gene id: 1244531:CIG1485E_RS05130
uniprot id: A0A076FGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1244531:CIG1485E RS00875
gene id: 1244531:CIG1485E_RS00875
uniprot id: A0A076F991
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1244531:CIG1485E RS04800
gene id: 1244531:CIG1485E_RS04800
uniprot id: A0A076F998
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1244531:CIG1485E RS03875
gene id: 1244531:CIG1485E_RS03875
uniprot id: A0A076FA81
names: Similarity
messages: Belongs to the AdoMet synthase family.

1244531:CIG1485E RS08145
gene id: 1244531:CIG1485E_RS08145
uniprot id: A0A076FCU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1244531:CIG1485E RS01555
gene id: 1244531:CIG1485E_RS01555
uniprot id: A0A076F9I3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS04810
gene id: 1244531:CIG1485E_RS04810
uniprot id: A0A076FBI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1244531:CIG1485E RS07170
gene id: 1244531:CIG1485E_RS07170
uniprot id: A0A076FB80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1244531:CIG1485E RS04045
gene id: 1244531:CIG1485E_RS04045
uniprot id: A0A076F8T9
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

1244531:CIG1485E RS00855
gene id: 1244531:CIG1485E_RS00855
uniprot id: A0A076F8M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1244531:CIG1485E RS05155
gene id: 1244531:CIG1485E_RS05155
uniprot id: A0A1B3IVZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1244531:CIG1485E RS07545
gene id: 1244531:CIG1485E_RS07545
uniprot id: A0A076FAU7
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

1244531:CIG1485E RS06025
gene id: 1244531:CIG1485E_RS06025
uniprot id: A0A076FC84
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.
messages: Periplasm

1244531:CIG1485E RS07270
gene id: 1244531:CIG1485E_RS07270
uniprot id: A0A076FBB4
names: Similarity
messages: Belongs to the peptidase S49 family.

1244531:CIG1485E RS08030
gene id: 1244531:CIG1485E_RS08030
uniprot id: A0A076FB05
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1244531:CIG1485E RS06285
gene id: 1244531:CIG1485E_RS06285
uniprot id: A0A076FA58
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04745
gene id: 1244531:CIG1485E_RS04745
uniprot id: A0A076FG46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

1244531:CIG1485E RS01910
gene id: 1244531:CIG1485E_RS01910
uniprot id: A0A076F7M2
names: Similarity
messages: Belongs to the glutamate synthase family.

1244531:CIG1485E RS08050
gene id: 1244531:CIG1485E_RS08050
uniprot id: A0A076FHZ8
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1244531:CIG1485E RS03360
gene id: 1244531:CIG1485E_RS03360
uniprot id: A0A076F8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1244531:CIG1485E RS05795
gene id: 1244531:CIG1485E_RS05795
uniprot id: A0A076FAJ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS06405
gene id: 1244531:CIG1485E_RS06405
uniprot id: A0A076FBN2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1244531:CIG1485E RS00775
gene id: 1244531:CIG1485E_RS00775
uniprot id: A0A076F985
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1244531:CIG1485E RS02835
gene id: 1244531:CIG1485E_RS02835
uniprot id: A0A076FAD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1244531:CIG1485E RS03660
gene id: 1244531:CIG1485E_RS03660
uniprot id: A0A076F9A8
names: Similarity
messages: Belongs to the catalase family.

1244531:CIG1485E RS09530
gene id: 1244531:CIG1485E_RS09530
uniprot id: A0A076FHT5
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

1244531:CIG1485E RS05850
gene id: 1244531:CIG1485E_RS05850
uniprot id: A0A076FC48
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS05380
gene id: 1244531:CIG1485E_RS05380
uniprot id: A0A076FGJ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

1244531:CIG1485E RS02970
gene id: 1244531:CIG1485E_RS02970
uniprot id: A0A076FF43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1244531:CIG1485E RS00725
gene id: 1244531:CIG1485E_RS00725
uniprot id: A0A076F8K4
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS03130
gene id: 1244531:CIG1485E_RS03130
uniprot id: A0A076FF67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1244531:CIG1485E RS07985
gene id: 1244531:CIG1485E_RS07985
uniprot id: A0A076FDF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1244531:CIG1485E RS06580
gene id: 1244531:CIG1485E_RS06580
uniprot id: A0A076FAX0
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1244531:CIG1485E RS07555
gene id: 1244531:CIG1485E_RS07555
uniprot id: A0A076FD99
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1244531:CIG1485E RS06065
gene id: 1244531:CIG1485E_RS06065
uniprot id: A0A076FA20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS00360
gene id: 1244531:CIG1485E_RS00360
uniprot id: A0A076F6L1
names: Similarity
messages: Belongs to the NAPRTase family.

1244531:CIG1485E RS01710
gene id: 1244531:CIG1485E_RS01710
uniprot id: A0A076F938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1244531:CIG1485E RS02445
gene id: 1244531:CIG1485E_RS02445
uniprot id: A0A076F9K3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1244531:CIG1485E RS02235
gene id: 1244531:CIG1485E_RS02235
uniprot id: A0A076FA07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1244531:CIG1485E RS04245
gene id: 1244531:CIG1485E_RS04245
uniprot id: A0A076F8X8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS00740
gene id: 1244531:CIG1485E_RS00740
uniprot id: A0A076F7J8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1244531:CIG1485E RS00455
gene id: 1244531:CIG1485E_RS00455
uniprot id: A0A076FDR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1244531:CIG1485E RS03385
gene id: 1244531:CIG1485E_RS03385
uniprot id: A0A076F8H3
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS05940
gene id: 1244531:CIG1485E_RS05940
uniprot id: A0A076F9Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS07930
gene id: 1244531:CIG1485E_RS07930
uniprot id: A0A076FBT6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1244531:CIG1485E RS05355
gene id: 1244531:CIG1485E_RS05355
uniprot id: A0A076FGI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1244531:CIG1485E RS04770
gene id: 1244531:CIG1485E_RS04770
uniprot id: A0A076FG53
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1244531:CIG1485E RS04680
gene id: 1244531:CIG1485E_RS04680
uniprot id: A0A076F9X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1244531:CIG1485E RS06680
gene id: 1244531:CIG1485E_RS06680
uniprot id: A0A076FH62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1244531:CIG1485E RS07315
gene id: 1244531:CIG1485E_RS07315
uniprot id: A0A076FAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1244531:CIG1485E RS03250
gene id: 1244531:CIG1485E_RS03250
uniprot id: A0A076F9Y0
names: Similarity
messages: Belongs to the UbiD family.

1244531:CIG1485E RS03335
gene id: 1244531:CIG1485E_RS03335
uniprot id: A0A076F8G4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1244531:CIG1485E RS06900
gene id: 1244531:CIG1485E_RS06900
uniprot id: A0A076FB17
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1244531:CIG1485E RS06880
gene id: 1244531:CIG1485E_RS06880
uniprot id: A0A076FCS5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1244531:CIG1485E RS08140
gene id: 1244531:CIG1485E_RS08140
uniprot id: A0A076FDI0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1244531:CIG1485E RS07540
gene id: 1244531:CIG1485E_RS07540
uniprot id: A0A076FHS3
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

1244531:CIG1485E RS08190
gene id: 1244531:CIG1485E_RS08190
uniprot id: A0A076FDI9
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04010
gene id: 1244531:CIG1485E_RS04010
uniprot id: A0A076FAB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

1244531:CIG1485E RS04040
gene id: 1244531:CIG1485E_RS04040
uniprot id: A0A076FFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS00525
gene id: 1244531:CIG1485E_RS00525
uniprot id: A0A076F8G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1244531:CIG1485E RS06630
gene id: 1244531:CIG1485E_RS06630
uniprot id: A0A076FH52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1244531:CIG1485E RS07550
gene id: 1244531:CIG1485E_RS07550
uniprot id: A0A076FBM4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1244531:CIG1485E RS03530
gene id: 1244531:CIG1485E_RS03530
uniprot id: A0A076F8J1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1244531:CIG1485E RS04015
gene id: 1244531:CIG1485E_RS04015
uniprot id: A0A076FFM1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1244531:CIG1485E RS04450
gene id: 1244531:CIG1485E_RS04450
uniprot id: A0A076F918
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1244531:CIG1485E RS01620
gene id: 1244531:CIG1485E_RS01620
uniprot id: A0A076F7G1
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01065
gene id: 1244531:CIG1485E_RS01065
uniprot id: A0A076F725
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1244531:CIG1485E RS04805
gene id: 1244531:CIG1485E_RS04805
uniprot id: A0A076FA11
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

1244531:CIG1485E RS00925
gene id: 1244531:CIG1485E_RS00925
uniprot id: A0A076F995
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01570
gene id: 1244531:CIG1485E_RS01570
uniprot id: A0A076F7E7
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1244531:CIG1485E RS07990
gene id: 1244531:CIG1485E_RS07990
uniprot id: A0A076FCR4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS03110
gene id: 1244531:CIG1485E_RS03110
uniprot id: A0A076F8D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1244531:CIG1485E RS08195
gene id: 1244531:CIG1485E_RS08195
uniprot id: A0A076FCU9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS03435
gene id: 1244531:CIG1485E_RS03435
uniprot id: A0A076F8I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1244531:CIG1485E RS06145
gene id: 1244531:CIG1485E_RS06145
uniprot id: A0A076FCC2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1244531:CIG1485E RS04300
gene id: 1244531:CIG1485E_RS04300
uniprot id: A0A076F8Z0
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1244531:CIG1485E RS05950
gene id: 1244531:CIG1485E_RS05950
uniprot id: A0A076FC69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS07920
gene id: 1244531:CIG1485E_RS07920
uniprot id: A0A076FHY0
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1244531:CIG1485E RS01120
gene id: 1244531:CIG1485E_RS01120
uniprot id: A0A076F739
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1244531:CIG1485E RS03200
gene id: 1244531:CIG1485E_RS03200
uniprot id: A0A076F9X2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS08035
gene id: 1244531:CIG1485E_RS08035
uniprot id: A0A076FBV2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1244531:CIG1485E RS01430
gene id: 1244531:CIG1485E_RS01430
uniprot id: A0A076F9G3
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS02840
gene id: 1244531:CIG1485E_RS02840
uniprot id: A0A076F9R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS02080
gene id: 1244531:CIG1485E_RS02080
uniprot id: A0A076F8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

1244531:CIG1485E RS08120
gene id: 1244531:CIG1485E_RS08120
uniprot id: A0A076FDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1244531:CIG1485E RS09220
gene id: 1244531:CIG1485E_RS09220
uniprot id: A0A076FHS2
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1244531:CIG1485E RS03525
gene id: 1244531:CIG1485E_RS03525
uniprot id: A0A076FFB6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1244531:CIG1485E RS01955
gene id: 1244531:CIG1485E_RS01955
uniprot id: A0A076FEJ1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS09170
gene id: 1244531:CIG1485E_RS09170
uniprot id: A0A076FA63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

1244531:CIG1485E RS08155
gene id: 1244531:CIG1485E_RS08155
uniprot id: A0A076FB26
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1244531:CIG1485E RS03855
gene id: 1244531:CIG1485E_RS03855
uniprot id: A0A076FFI5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1244531:CIG1485E RS07110
gene id: 1244531:CIG1485E_RS07110
uniprot id: A0A076FHF7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS07490
gene id: 1244531:CIG1485E_RS07490
uniprot id: A0A076FHR1
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

1244531:CIG1485E RS03035
gene id: 1244531:CIG1485E_RS03035
uniprot id: A0A076F8Y0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS03350
gene id: 1244531:CIG1485E_RS03350
uniprot id: A0A076F9Z1
names: Similarity
messages: Belongs to the UPF0423 family.

1244531:CIG1485E RS01680
gene id: 1244531:CIG1485E_RS01680
uniprot id: A0A076F9M1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1244531:CIG1485E RS00980
gene id: 1244531:CIG1485E_RS00980
uniprot id: A0A076F8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS05655
gene id: 1244531:CIG1485E_RS05655
uniprot id: A0A076FBB7
names: Similarity
messages: Belongs to the threonine synthase family.

1244531:CIG1485E RS05835
gene id: 1244531:CIG1485E_RS05835
uniprot id: A0A076FGR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1244531:CIG1485E RS06790
gene id: 1244531:CIG1485E_RS06790
uniprot id: A0A076FAD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

1244531:CIG1485E RS07700
gene id: 1244531:CIG1485E_RS07700
uniprot id: A0A076FBP9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1244531:CIG1485E RS01545
gene id: 1244531:CIG1485E_RS01545
uniprot id: A0A076F7E1
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1244531:CIG1485E RS07485
gene id: 1244531:CIG1485E_RS07485
uniprot id: A0A076FCH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1244531:CIG1485E RS04005
gene id: 1244531:CIG1485E_RS04005
uniprot id: A0A076FAY4
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS07440
gene id: 1244531:CIG1485E_RS07440
uniprot id: A0A076FAR5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1244531:CIG1485E RS04930
gene id: 1244531:CIG1485E_RS04930
uniprot id: A0A076F9F5
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1244531:CIG1485E RS07410
gene id: 1244531:CIG1485E_RS07410
uniprot id: A0A076FHM9
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

1244531:CIG1485E RS06675
gene id: 1244531:CIG1485E_RS06675
uniprot id: A0A076FBV4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1244531:CIG1485E RS00805
gene id: 1244531:CIG1485E_RS00805
uniprot id: A0A076F987
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS03325
gene id: 1244531:CIG1485E_RS03325
uniprot id: A0A076F9Y7
names: Subcellular Location Annotation
messages: Secreted

1244531:CIG1485E RS04765
gene id: 1244531:CIG1485E_RS04765
uniprot id: A0A076FAS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS02305
gene id: 1244531:CIG1485E_RS02305
uniprot id: A0A076F8K6
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS07640
gene id: 1244531:CIG1485E_RS07640
uniprot id: A0A076FHT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1244531:CIG1485E RS00095
gene id: 1244531:CIG1485E_RS00095
uniprot id: A0A076FDL4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1244531:CIG1485E RS01475
gene id: 1244531:CIG1485E_RS01475
uniprot id: A0A076F7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS07320
gene id: 1244531:CIG1485E_RS07320
uniprot id: A0A076FBE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1244531:CIG1485E RS01525
gene id: 1244531:CIG1485E_RS01525
uniprot id: A0A076F805
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1244531:CIG1485E RS02495
gene id: 1244531:CIG1485E_RS02495
uniprot id: A0A076F9K9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1244531:CIG1485E RS02020
gene id: 1244531:CIG1485E_RS02020
uniprot id: A0A076F8B2
names: Similarity
messages: Belongs to the antibiotic N-acetyltransferase family.

1244531:CIG1485E RS08290
gene id: 1244531:CIG1485E_RS08290
uniprot id: A0A076FB50
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS06320
gene id: 1244531:CIG1485E_RS06320
uniprot id: A0A076FAT9
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS07150
gene id: 1244531:CIG1485E_RS07150
uniprot id: A0A076FCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1244531:CIG1485E RS00405
gene id: 1244531:CIG1485E_RS00405
uniprot id: A0A076FDR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1244531:CIG1485E RS01550
gene id: 1244531:CIG1485E_RS01550
uniprot id: A0A076F809
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1244531:CIG1485E RS03000
gene id: 1244531:CIG1485E_RS03000
uniprot id: A0A076FF48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS01375
gene id: 1244531:CIG1485E_RS01375
uniprot id: A0A076F7X8
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1244531:CIG1485E RS00055
gene id: 1244531:CIG1485E_RS00055
uniprot id: A0A076F794
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

1244531:CIG1485E RS00280
gene id: 1244531:CIG1485E_RS00280
uniprot id: A0A076FDP5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1244531:CIG1485E RS06890
gene id: 1244531:CIG1485E_RS06890
uniprot id: A0A076FH97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

1244531:CIG1485E RS00500
gene id: 1244531:CIG1485E_RS00500
uniprot id: A0A076F8G1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1244531:CIG1485E RS02330
gene id: 1244531:CIG1485E_RS02330
uniprot id: A0A076F8K9
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

1244531:CIG1485E RS02115
gene id: 1244531:CIG1485E_RS02115
uniprot id: A0A076F9D6
names: Similarity
messages: Belongs to the ModE family.

1244531:CIG1485E RS03820
gene id: 1244531:CIG1485E_RS03820
uniprot id: A0A076FAU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1244531:CIG1485E RS07760
gene id: 1244531:CIG1485E_RS07760
uniprot id: A0A076FCN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS03775
gene id: 1244531:CIG1485E_RS03775
uniprot id: A0A076FA55
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1244531:CIG1485E RS02500
gene id: 1244531:CIG1485E_RS02500
uniprot id: A0A076FEW7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1244531:CIG1485E RS08125
gene id: 1244531:CIG1485E_RS08125
uniprot id: A0A076FI08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1244531:CIG1485E RS06970
gene id: 1244531:CIG1485E_RS06970
uniprot id: A0A076FAG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1244531:CIG1485E RS04235
gene id: 1244531:CIG1485E_RS04235
uniprot id: A0A076FAF9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1244531:CIG1485E RS03915
gene id: 1244531:CIG1485E_RS03915
uniprot id: A0A076F9E5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1244531:CIG1485E RS05960
gene id: 1244531:CIG1485E_RS05960
uniprot id: A0A076FGT0
names: Similarity
messages: Belongs to the GSP E family.

1244531:CIG1485E RS06855
gene id: 1244531:CIG1485E_RS06855
uniprot id: A0A076FCR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1244531:CIG1485E RS02880
gene id: 1244531:CIG1485E_RS02880
uniprot id: A0A076F8V6
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1244531:CIG1485E RS02680
gene id: 1244531:CIG1485E_RS02680
uniprot id: A0A076F8S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Periplasm

1244531:CIG1485E RS03790
gene id: 1244531:CIG1485E_RS03790
uniprot id: A0A076F9C8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1244531:CIG1485E RS06445
gene id: 1244531:CIG1485E_RS06445
uniprot id: A0A076FAV2
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1244531:CIG1485E RS03870
gene id: 1244531:CIG1485E_RS03870
uniprot id: A0A076FAV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Membrane

1244531:CIG1485E RS04555
gene id: 1244531:CIG1485E_RS04555
uniprot id: A0A076F9U4
names: Similarity
messages: Belongs to the ClpX chaperone family. HslU subfamily.

1244531:CIG1485E RS06640
gene id: 1244531:CIG1485E_RS06640
uniprot id: A0A076FAX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1244531:CIG1485E RS07400
gene id: 1244531:CIG1485E_RS07400
uniprot id: A0A076FD34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1244531:CIG1485E RS01835
gene id: 1244531:CIG1485E_RS01835
uniprot id: A0A076F7K4
names: Similarity
messages: Belongs to the TrpF family.

1244531:CIG1485E RS05615
gene id: 1244531:CIG1485E_RS05615
uniprot id: A0A076F9Q4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS04035
gene id: 1244531:CIG1485E_RS04035
uniprot id: A0A076FAB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

1244531:CIG1485E RS08310
gene id: 1244531:CIG1485E_RS08310
uniprot id: A0A076FI26
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1244531:CIG1485E RS02615
gene id: 1244531:CIG1485E_RS02615
uniprot id: A0A076F9M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS05920
gene id: 1244531:CIG1485E_RS05920
uniprot id: A0A076FAM5
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1244531:CIG1485E RS02570
gene id: 1244531:CIG1485E_RS02570
uniprot id: A0A076F9M0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1244531:CIG1485E RS05820
gene id: 1244531:CIG1485E_RS05820
uniprot id: A0A076FAK4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1244531:CIG1485E RS06795
gene id: 1244531:CIG1485E_RS06795
uniprot id: A0A076FAZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1244531:CIG1485E RS03305
gene id: 1244531:CIG1485E_RS03305
uniprot id: A0A076F8F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

1244531:CIG1485E RS03900
gene id: 1244531:CIG1485E_RS03900
uniprot id: A0A076FA87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Membrane

1244531:CIG1485E RS01075
gene id: 1244531:CIG1485E_RS01075
uniprot id: A0A076F9B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1244531:CIG1485E RS07180
gene id: 1244531:CIG1485E_RS07180
uniprot id: A0A076FC60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1244531:CIG1485E RS06075
gene id: 1244531:CIG1485E_RS06075
uniprot id: A0A076FC98
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1244531:CIG1485E RS01445
gene id: 1244531:CIG1485E_RS01445
uniprot id: A0A076F7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1244531:CIG1485E RS01890
gene id: 1244531:CIG1485E_RS01890
uniprot id: A0A076F880
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1244531:CIG1485E RS04550
gene id: 1244531:CIG1485E_RS04550
uniprot id: A0A076F942
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1244531:CIG1485E RS01650
gene id: 1244531:CIG1485E_RS01650
uniprot id: A0A076F831
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS03185
gene id: 1244531:CIG1485E_RS03185
uniprot id: A0A076F8E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1244531:CIG1485E RS04435
gene id: 1244531:CIG1485E_RS04435
uniprot id: A0A076FB68
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1244531:CIG1485E RS07390
gene id: 1244531:CIG1485E_RS07390
uniprot id: A0A076FAQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1244531:CIG1485E RS05635
gene id: 1244531:CIG1485E_RS05635
uniprot id: A0A076FGM9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1244531:CIG1485E RS00715
gene id: 1244531:CIG1485E_RS00715
uniprot id: A0A076F7J5
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS02240
gene id: 1244531:CIG1485E_RS02240
uniprot id: A0A076F9F7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1244531:CIG1485E RS00450
gene id: 1244531:CIG1485E_RS00450
uniprot id: A0A076F8F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1244531:CIG1485E RS08540
gene id: 1244531:CIG1485E_RS08540
uniprot id: A0A076FC39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1244531:CIG1485E RS01035
gene id: 1244531:CIG1485E_RS01035
uniprot id: A0A076FE26
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1244531:CIG1485E RS01260
gene id: 1244531:CIG1485E_RS01260
uniprot id: A0A076F8U6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1244531:CIG1485E RS00515
gene id: 1244531:CIG1485E_RS00515
uniprot id: A0A076F7G6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1244531:CIG1485E RS03395
gene id: 1244531:CIG1485E_RS03395
uniprot id: A0A076FAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

1244531:CIG1485E RS03910
gene id: 1244531:CIG1485E_RS03910
uniprot id: A0A076F8R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1244531:CIG1485E RS00540
gene id: 1244531:CIG1485E_RS00540
uniprot id: A0A076F7H1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1244531:CIG1485E RS03155
gene id: 1244531:CIG1485E_RS03155
uniprot id: A0A076FF71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1244531:CIG1485E RS00485
gene id: 1244531:CIG1485E_RS00485
uniprot id: A0A076F6N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1244531:CIG1485E RS05455
gene id: 1244531:CIG1485E_RS05455
uniprot id: A0A076FB74
names: Similarity
messages: Belongs to the peptidase M16 family.

1244531:CIG1485E RS01775
gene id: 1244531:CIG1485E_RS01775
uniprot id: A0A076F857
names: Similarity
messages: Belongs to the nitroreductase family.

1244531:CIG1485E RS07335
gene id: 1244531:CIG1485E_RS07335
uniprot id: A0A076FHL4
names: Similarity
messages: Belongs to the fabD family.

1244531:CIG1485E RS07450
gene id: 1244531:CIG1485E_RS07450
uniprot id: A0A076FD47
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

1244531:CIG1485E RS07380
gene id: 1244531:CIG1485E_RS07380
uniprot id: A0A076FCB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1244531:CIG1485E RS01045
gene id: 1244531:CIG1485E_RS01045
uniprot id: A0A076F7Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
messages: Membrane

1244531:CIG1485E RS08270
gene id: 1244531:CIG1485E_RS08270
uniprot id: A0A076FBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1244531:CIG1485E RS01610
gene id: 1244531:CIG1485E_RS01610
uniprot id: A0A076F921
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1244531:CIG1485E RS06780
gene id: 1244531:CIG1485E_RS06780
uniprot id: A0A076FBX2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS00585
gene id: 1244531:CIG1485E_RS00585
uniprot id: A0A076F6Q6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1244531:CIG1485E RS06085
gene id: 1244531:CIG1485E_RS06085
uniprot id: A0A076FGV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1244531:CIG1485E RS03840
gene id: 1244531:CIG1485E_RS03840
uniprot id: A0A076F9D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1244531:CIG1485E RS00050
gene id: 1244531:CIG1485E_RS00050
uniprot id: A0A076F6G0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1244531:CIG1485E RS00330
gene id: 1244531:CIG1485E_RS00330
uniprot id: A0A076FDQ3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1244531:CIG1485E RS01500
gene id: 1244531:CIG1485E_RS01500
uniprot id: A0A076F801
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1244531:CIG1485E RS00995
gene id: 1244531:CIG1485E_RS00995
uniprot id: A0A076F7P3
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01330
gene id: 1244531:CIG1485E_RS01330
uniprot id: A0A076F9E7
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1244531:CIG1485E RS01705
gene id: 1244531:CIG1485E_RS01705
uniprot id: A0A076F9M8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1244531:CIG1485E RS06160
gene id: 1244531:CIG1485E_RS06160
uniprot id: A0A076FA34
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1244531:CIG1485E RS02150
gene id: 1244531:CIG1485E_RS02150
uniprot id: A0A076F7V1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1244531:CIG1485E RS04030
gene id: 1244531:CIG1485E_RS04030
uniprot id: A0A076FAY8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS08550
gene id: 1244531:CIG1485E_RS08550
uniprot id: A0A076FCZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1244531:CIG1485E RS05280
gene id: 1244531:CIG1485E_RS05280
uniprot id: A0A076FGH7
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1244531:CIG1485E RS01185
gene id: 1244531:CIG1485E_RS01185
uniprot id: A0A076F8T1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1244531:CIG1485E RS08255
gene id: 1244531:CIG1485E_RS08255
uniprot id: A0A076FCV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS05445
gene id: 1244531:CIG1485E_RS05445
uniprot id: A0A076FAD4
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS05855
gene id: 1244531:CIG1485E_RS05855
uniprot id: A0A076FBE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1244531:CIG1485E RS06205
gene id: 1244531:CIG1485E_RS06205
uniprot id: A0A076FGY1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1244531:CIG1485E RS05520
gene id: 1244531:CIG1485E_RS05520
uniprot id: A0A076FAE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1244531:CIG1485E RS05580
gene id: 1244531:CIG1485E_RS05580
uniprot id: A0A076FBA0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1244531:CIG1485E RS00490
gene id: 1244531:CIG1485E_RS00490
uniprot id: A0A076F7G3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1244531:CIG1485E RS04905
gene id: 1244531:CIG1485E_RS04905
uniprot id: A0A076F9C6
names: Function
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

1244531:CIG1485E RS06775
gene id: 1244531:CIG1485E_RS06775
uniprot id: A0A076FCQ3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1244531:CIG1485E RS02120
gene id: 1244531:CIG1485E_RS02120
uniprot id: A0A076FEL9
names: Similarity
messages: Belongs to the MlaA family.

1244531:CIG1485E RS06220
gene id: 1244531:CIG1485E_RS06220
uniprot id: A0A076FCE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

1244531:CIG1485E RS01625
gene id: 1244531:CIG1485E_RS01625
uniprot id: A0A076F824
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1244531:CIG1485E RS06095
gene id: 1244531:CIG1485E_RS06095
uniprot id: A0A076FAR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS00905
gene id: 1244531:CIG1485E_RS00905
uniprot id: A0A076F8N4
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04470
gene id: 1244531:CIG1485E_RS04470
uniprot id: A0A076FFX7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

1244531:CIG1485E RS00440
gene id: 1244531:CIG1485E_RS00440
uniprot id: A0A076F7F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1244531:CIG1485E RS07125
gene id: 1244531:CIG1485E_RS07125
uniprot id: A0A076FCX6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS01845
gene id: 1244531:CIG1485E_RS01845
uniprot id: A0A076F9R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1244531:CIG1485E RS05490
gene id: 1244531:CIG1485E_RS05490
uniprot id: A0A076F9M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1244531:CIG1485E RS07585
gene id: 1244531:CIG1485E_RS07585
uniprot id: A0A076FCK0
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1244531:CIG1485E RS04660
gene id: 1244531:CIG1485E_RS04660
uniprot id: A0A076FBE6
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1244531:CIG1485E RS03220
gene id: 1244531:CIG1485E_RS03220
uniprot id: A0A076FAJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1244531:CIG1485E RS01920
gene id: 1244531:CIG1485E_RS01920
uniprot id: A0A076F9S9
names: Similarity
messages: Belongs to the LOG family.

1244531:CIG1485E RS00710
gene id: 1244531:CIG1485E_RS00710
uniprot id: A0A076F6T4
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS01425
gene id: 1244531:CIG1485E_RS01425
uniprot id: A0A076F7Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1244531:CIG1485E RS02535
gene id: 1244531:CIG1485E_RS02535
uniprot id: A0A076F8P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1244531:CIG1485E RS00430
gene id: 1244531:CIG1485E_RS00430
uniprot id: A0A076FDR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1244531:CIG1485E RS01240
gene id: 1244531:CIG1485E_RS01240
uniprot id: A0A076FE63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1244531:CIG1485E RS01755
gene id: 1244531:CIG1485E_RS01755
uniprot id: A0A076F9P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1244531:CIG1485E RS03710
gene id: 1244531:CIG1485E_RS03710
uniprot id: A0A076F9B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1244531:CIG1485E RS07935
gene id: 1244531:CIG1485E_RS07935
uniprot id: A0A076FDE6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1244531:CIG1485E RS04460
gene id: 1244531:CIG1485E_RS04460
uniprot id: A0A076FB87
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1244531:CIG1485E RS07810
gene id: 1244531:CIG1485E_RS07810
uniprot id: A0A076FCN9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1244531:CIG1485E RS01115
gene id: 1244531:CIG1485E_RS01115
uniprot id: A0A076FE42
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS01020
gene id: 1244531:CIG1485E_RS01020
uniprot id: A0A076F7P7
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1244531:CIG1485E RS08070
gene id: 1244531:CIG1485E_RS08070
uniprot id: A0A076FDG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably functions as a manganese efflux pump.

1244531:CIG1485E RS06690
gene id: 1244531:CIG1485E_RS06690
uniprot id: A0A076FAC4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1244531:CIG1485E RS07995
gene id: 1244531:CIG1485E_RS07995
uniprot id: A0A076FHZ0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1244531:CIG1485E RS03835
gene id: 1244531:CIG1485E_RS03835
uniprot id: A0A076F8P7
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.

1244531:CIG1485E RS00510
gene id: 1244531:CIG1485E_RS00510
uniprot id: A0A076F6N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1244531:CIG1485E RS02865
gene id: 1244531:CIG1485E_RS02865
uniprot id: A0A076F9S2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1244531:CIG1485E RS04900
gene id: 1244531:CIG1485E_RS04900
uniprot id: A0A076FG87
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1244531:CIG1485E RS07135
gene id: 1244531:CIG1485E_RS07135
uniprot id: A0A076FHG4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1244531:CIG1485E RS05095
gene id: 1244531:CIG1485E_RS05095
uniprot id: A0A076FB15
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1244531:CIG1485E RS06670
gene id: 1244531:CIG1485E_RS06670
uniprot id: A0A076FCN7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1244531:CIG1485E RS06665
gene id: 1244531:CIG1485E_RS06665
uniprot id: A0A076FAY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1244531:CIG1485E RS05485
gene id: 1244531:CIG1485E_RS05485
uniprot id: A0A076FGK3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1244531:CIG1485E RS00630
gene id: 1244531:CIG1485E_RS00630
uniprot id: A0A076FDU9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1244531:CIG1485E RS01795
gene id: 1244531:CIG1485E_RS01795
uniprot id: A0A076F7K0
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS08300
gene id: 1244531:CIG1485E_RS08300
uniprot id: A0A076FDK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1244531:CIG1485E RS03805
gene id: 1244531:CIG1485E_RS03805
uniprot id: A0A076FFH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1244531:CIG1485E RS08015
gene id: 1244531:CIG1485E_RS08015
uniprot id: A0A076FDF8
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS05475
gene id: 1244531:CIG1485E_RS05475
uniprot id: A0A076FBY4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1244531:CIG1485E RS04100
gene id: 1244531:CIG1485E_RS04100
uniprot id: A0A076FAC8
names: Similarity
messages: Belongs to the TrpC family.

1244531:CIG1485E RS05630
gene id: 1244531:CIG1485E_RS05630
uniprot id: A0A076FBB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS06165
gene id: 1244531:CIG1485E_RS06165
uniprot id: A0A076FAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1244531:CIG1485E RS07815
gene id: 1244531:CIG1485E_RS07815
uniprot id: A0A076FHX0
names: Similarity
messages: Belongs to the UPF0234 family.

1244531:CIG1485E RS00735
gene id: 1244531:CIG1485E_RS00735
uniprot id: A0A076F6U0
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1244531:CIG1485E RS04350
gene id: 1244531:CIG1485E_RS04350
uniprot id: A0A076F900
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1244531:CIG1485E RS08545
gene id: 1244531:CIG1485E_RS08545
uniprot id: A0A076FDP4
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS04775
gene id: 1244531:CIG1485E_RS04775
uniprot id: A0A076F990
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1244531:CIG1485E RS06905
gene id: 1244531:CIG1485E_RS06905
uniprot id: A0A076FCT0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1244531:CIG1485E RS03795
gene id: 1244531:CIG1485E_RS03795
uniprot id: A0A076FAT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1244531:CIG1485E RS03985
gene id: 1244531:CIG1485E_RS03985
uniprot id: A0A076F8S8
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

1244531:CIG1485E RS03560
gene id: 1244531:CIG1485E_RS03560
uniprot id: A0A076F981
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1244531:CIG1485E RS06370
gene id: 1244531:CIG1485E_RS06370
uniprot id: A0A076FAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1244531:CIG1485E RS05955
gene id: 1244531:CIG1485E_RS05955
uniprot id: A0A076FBF9
names: Subcellular Location Annotation
messages: Membrane

1244531:CIG1485E RS07630
gene id: 1244531:CIG1485E_RS07630
uniprot id: A0A076FDB2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1244531:CIG1485E RS06400
gene id: 1244531:CIG1485E_RS06400
uniprot id: A0A076FCI1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1244531:CIG1485E RS07570
gene id: 1244531:CIG1485E_RS07570
uniprot id: A0A076FAV1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1244531:CIG1485E RS03125
gene id: 1244531:CIG1485E_RS03125
uniprot id: A0A076F9V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1244531:CIG1485E RS00340
gene id: 1244531:CIG1485E_RS00340
uniprot id: A0A076F7E3
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1244531:CIG1485E RS00860
gene id: 1244531:CIG1485E_RS00860
uniprot id: A0A076FDY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1244531:CIG1485E RS08480
gene id: 1244531:CIG1485E_RS08480
uniprot id: A0A076FI39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1244531:CIG1485E RS07840
gene id: 1244531:CIG1485E_RS07840
uniprot id: A0A076FHX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1244531:CIG1485E RS04305
gene id: 1244531:CIG1485E_RS04305
uniprot id: A0A076F9N0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1244531:CIG1485E RS06530
gene id: 1244531:CIG1485E_RS06530
uniprot id: A0A076FBS2
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS03955
gene id: 1244531:CIG1485E_RS03955
uniprot id: A0A076FFK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1244531:CIG1485E RS08265
gene id: 1244531:CIG1485E_RS08265
uniprot id: A0A076FB44
names: Similarity
messages: Belongs to the RutC family.

1244531:CIG1485E RS07395
gene id: 1244531:CIG1485E_RS07395
uniprot id: A0A076FBG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1244531:CIG1485E RS06080
gene id: 1244531:CIG1485E_RS06080
uniprot id: A0A076FBH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1244531:CIG1485E RS04070
gene id: 1244531:CIG1485E_RS04070
uniprot id: A0A076FAZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1244531:CIG1485E RS04255
gene id: 1244531:CIG1485E_RS04255
uniprot id: A0A076FB19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1244531:CIG1485E RS09535
gene id: 1244531:CIG1485E_RS09535
uniprot id: A0A076FAV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1244531:CIG1485E RS06375
gene id: 1244531:CIG1485E_RS06375
uniprot id: A0A076FCH5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1244531:CIG1485E RS08010
gene id: 1244531:CIG1485E_RS08010
uniprot id: A0A076FBU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1244531:CIG1485E RS00025
gene id: 1244531:CIG1485E_RS00025
uniprot id: A0A076F6F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

1244531:CIG1485E RS01760
gene id: 1244531:CIG1485E_RS01760
uniprot id: A0A076F950
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

1244531:CIG1485E RS07245
gene id: 1244531:CIG1485E_RS07245
uniprot id: A0A076FBA6
names: Cofactor
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1244531:CIG1485E RS05035
gene id: 1244531:CIG1485E_RS05035
uniprot id: A0A076FA76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1244531:CIG1485E RS02345
gene id: 1244531:CIG1485E_RS02345
uniprot id: A0A076FEU5
names: Caution
names: Function
names: Similarity
messages: Belongs to the IspF family.
messages: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
messages: In the C-terminal section; belongs to the IspF family.
messages: In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1244531:CIG1485E RS00470
gene id: 1244531:CIG1485E_RS00470
uniprot id: A0A076F946
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1244531:CIG1485E RS00270
gene id: 1244531:CIG1485E_RS00270
uniprot id: A0A076F905
names: Similarity
messages: Belongs to the asparagine synthetase family.

1244531:CIG1485E RS00950
gene id: 1244531:CIG1485E_RS00950
uniprot id: A0A076F997
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.