1227739:HSW RS07305
gene id: 1227739:HSW_RS07305
uniprot id: W8EUC6
names: Similarity
messages: Belongs to the fabD family.

1227739:HSW RS04195
gene id: 1227739:HSW_RS04195
uniprot id: W8F2Y0
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1227739:HSW RS14645
gene id: 1227739:HSW_RS14645
uniprot id: W8EYZ3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS14570
gene id: 1227739:HSW_RS14570
uniprot id: W8F092
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS20960
gene id: 1227739:HSW_RS20960
uniprot id: W8F2M2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1227739:HSW RS03910
gene id: 1227739:HSW_RS03910
uniprot id: W8EUB3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1227739:HSW RS11570
gene id: 1227739:HSW_RS11570
uniprot id: W8EYM4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1227739:HSW RS15005
gene id: 1227739:HSW_RS15005
uniprot id: W8F356
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1227739:HSW RS18765
gene id: 1227739:HSW_RS18765
uniprot id: W8F2N0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1227739:HSW RS17060
gene id: 1227739:HSW_RS17060
uniprot id: W8F0C1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1227739:HSW RS13485
gene id: 1227739:HSW_RS13485
uniprot id: W8F660
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

1227739:HSW RS07195
gene id: 1227739:HSW_RS07195
uniprot id: W8F2E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1227739:HSW RS01855
gene id: 1227739:HSW_RS01855
uniprot id: W8F1H3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1227739:HSW RS03930
gene id: 1227739:HSW_RS03930
uniprot id: W8EWF2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1227739:HSW RS19425
gene id: 1227739:HSW_RS19425
uniprot id: W8F1N8
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1227739:HSW RS13030
gene id: 1227739:HSW_RS13030
uniprot id: W8EY37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1227739:HSW RS02170
gene id: 1227739:HSW_RS02170
uniprot id: W8ERG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1227739:HSW RS16475
gene id: 1227739:HSW_RS16475
uniprot id: W8F7W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1227739:HSW RS09235
gene id: 1227739:HSW_RS09235
uniprot id: W8F611
names: Similarity
messages: Belongs to the histone deacetylase family.

1227739:HSW RS03185
gene id: 1227739:HSW_RS03185
uniprot id: W8F079
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1227739:HSW RS09875
gene id: 1227739:HSW_RS09875
uniprot id: W8F6F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS19860
gene id: 1227739:HSW_RS19860
uniprot id: W8F202
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1227739:HSW RS00570
gene id: 1227739:HSW_RS00570
uniprot id: W8EQL2
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS01715
gene id: 1227739:HSW_RS01715
uniprot id: W8ER80
names: Similarity
messages: Belongs to the pirin family.

1227739:HSW RS04020
gene id: 1227739:HSW_RS04020
uniprot id: W8EWG5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03590
gene id: 1227739:HSW_RS03590
uniprot id: W8F0D9
names: Similarity
messages: Belongs to the DEAD box helicase family.

1227739:HSW RS16605
gene id: 1227739:HSW_RS16605
uniprot id: W8F1G1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1227739:HSW RS15865
gene id: 1227739:HSW_RS15865
uniprot id: W8F7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1227739:HSW RS11185
gene id: 1227739:HSW_RS11185
uniprot id: W8F7B1
names: Similarity
messages: Belongs to the peptidase C40 family.

1227739:HSW RS18960
gene id: 1227739:HSW_RS18960
uniprot id: W8F2R3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS16720
gene id: 1227739:HSW_RS16720
uniprot id: W8F055
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS16585
gene id: 1227739:HSW_RS16585
uniprot id: W8F034
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1227739:HSW RS20810
gene id: 1227739:HSW_RS20810
uniprot id: W8F6F6
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1227739:HSW RS01885
gene id: 1227739:HSW_RS01885
uniprot id: W8EZ97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

1227739:HSW RS17420
gene id: 1227739:HSW_RS17420
uniprot id: W8F1Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS06295
gene id: 1227739:HSW_RS06295
uniprot id: W8EVN6
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1227739:HSW RS14910
gene id: 1227739:HSW_RS14910
uniprot id: W8F0H3
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1227739:HSW RS22105
gene id: 1227739:HSW_RS22105
uniprot id: W8F398
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS19185
gene id: 1227739:HSW_RS19185
uniprot id: W8FC54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1227739:HSW RS04170
gene id: 1227739:HSW_RS04170
uniprot id: W8F0M9
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1227739:HSW RS21090
gene id: 1227739:HSW_RS21090
uniprot id: W8FD91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1227739:HSW RS12835
gene id: 1227739:HSW_RS12835
uniprot id: W8F5V3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1227739:HSW RS12905
gene id: 1227739:HSW_RS12905
uniprot id: W8EZC4
names: Similarity
messages: Belongs to the glutamine synthetase family.

1227739:HSW RS03255
gene id: 1227739:HSW_RS03255
uniprot id: W8F2F7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1227739:HSW RS13480
gene id: 1227739:HSW_RS13480
uniprot id: W8F8Q8
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

1227739:HSW RS17220
gene id: 1227739:HSW_RS17220
uniprot id: W8F0F9
names: Similarity
messages: Belongs to the peptidase M24B family.

1227739:HSW RS16265
gene id: 1227739:HSW_RS16265
uniprot id: W8EZY1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1227739:HSW RS07170
gene id: 1227739:HSW_RS07170
uniprot id: W8F2E2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1227739:HSW RS14350
gene id: 1227739:HSW_RS14350
uniprot id: W8F6M3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

1227739:HSW RS14155
gene id: 1227739:HSW_RS14155
uniprot id: W8F6I3
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS14830
gene id: 1227739:HSW_RS14830
uniprot id: W8EZ36
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS05100
gene id: 1227739:HSW_RS05100
uniprot id: W8F186
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1227739:HSW RS18705
gene id: 1227739:HSW_RS18705
uniprot id: W8F954
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1227739:HSW RS08050
gene id: 1227739:HSW_RS08050
uniprot id: W8F320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1227739:HSW RS16040
gene id: 1227739:HSW_RS16040
uniprot id: W8F3N6
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1227739:HSW RS09335
gene id: 1227739:HSW_RS09335
uniprot id: W8EZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1227739:HSW RS11890
gene id: 1227739:HSW_RS11890
uniprot id: W8F166
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1227739:HSW RS11225
gene id: 1227739:HSW_RS11225
uniprot id: W8EX20
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1227739:HSW RS21925
gene id: 1227739:HSW_RS21925
uniprot id: W8FB24
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS00575
gene id: 1227739:HSW_RS00575
uniprot id: W8F0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1227739:HSW RS02795
gene id: 1227739:HSW_RS02795
uniprot id: W8EVW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1227739:HSW RS23085
gene id: 1227739:HSW_RS23085
uniprot id: W8F8T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1227739:HSW RS12910
gene id: 1227739:HSW_RS12910
uniprot id: W8EY14
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1227739:HSW RS11710
gene id: 1227739:HSW_RS11710
uniprot id: W8EXA4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS10160
gene id: 1227739:HSW_RS10160
uniprot id: W8EVY5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS10350
gene id: 1227739:HSW_RS10350
uniprot id: W8EY11
names: Similarity
messages: Belongs to the DEAD box helicase family.

1227739:HSW RS04160
gene id: 1227739:HSW_RS04160
uniprot id: W8ESM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1227739:HSW RS10595
gene id: 1227739:HSW_RS10595
uniprot id: W8EY57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1227739:HSW RS14300
gene id: 1227739:HSW_RS14300
uniprot id: W8F6L3
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1227739:HSW RS00895
gene id: 1227739:HSW_RS00895
uniprot id: W8EYS3
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS21110
gene id: 1227739:HSW_RS21110
uniprot id: W8F2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1227739:HSW RS18860
gene id: 1227739:HSW_RS18860
uniprot id: W8F596
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1227739:HSW RS22080
gene id: 1227739:HSW_RS22080
uniprot id: W8F391
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS10695
gene id: 1227739:HSW_RS10695
uniprot id: W8F4J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1227739:HSW RS02285
gene id: 1227739:HSW_RS02285
uniprot id: W8F1Q7
names: Similarity
messages: Belongs to the peptidase U62 family.

1227739:HSW RS05605
gene id: 1227739:HSW_RS05605
uniprot id: W8EXI9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1227739:HSW RS13885
gene id: 1227739:HSW_RS13885
uniprot id: W8EZW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS20715
gene id: 1227739:HSW_RS20715
uniprot id: W8F6D7
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03850
gene id: 1227739:HSW_RS03850
uniprot id: W8EWE1
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1227739:HSW RS08990
gene id: 1227739:HSW_RS08990
uniprot id: W8EX45
names: Similarity
messages: Belongs to the Lgt family.

1227739:HSW RS12480
gene id: 1227739:HSW_RS12480
uniprot id: W8EZ43
names: Subunit
messages: Homodimer.

1227739:HSW RS10550
gene id: 1227739:HSW_RS10550
uniprot id: W8EWN2
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS16405
gene id: 1227739:HSW_RS16405
uniprot id: W8F3V5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1227739:HSW RS22940
gene id: 1227739:HSW_RS22940
uniprot id: W8F6Q6
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS18760
gene id: 1227739:HSW_RS18760
uniprot id: W8F578
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1227739:HSW RS18695
gene id: 1227739:HSW_RS18695
uniprot id: W8F1A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1227739:HSW RS12960
gene id: 1227739:HSW_RS12960
uniprot id: W8F8G1
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1227739:HSW RS16105
gene id: 1227739:HSW_RS16105
uniprot id: W8F169
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS20950
gene id: 1227739:HSW_RS20950
uniprot id: W8FD62
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS17980
gene id: 1227739:HSW_RS17980
uniprot id: W8F284
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1227739:HSW RS10635
gene id: 1227739:HSW_RS10635
uniprot id: W8F0H4
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1227739:HSW RS09400
gene id: 1227739:HSW_RS09400
uniprot id: W8F3R7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

1227739:HSW RS14785
gene id: 1227739:HSW_RS14785
uniprot id: W8F9I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1227739:HSW RS18915
gene id: 1227739:HSW_RS18915
uniprot id: W8F1E6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS07345
gene id: 1227739:HSW_RS07345
uniprot id: W8EW69
names: Subcellular Location Annotation
messages: Mitochondrion

1227739:HSW RS22520
gene id: 1227739:HSW_RS22520
uniprot id: W8ET09
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS09280
gene id: 1227739:HSW_RS09280
uniprot id: W8F3P1
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

1227739:HSW RS09365
gene id: 1227739:HSW_RS09365
uniprot id: W8EXB9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1227739:HSW RS12750
gene id: 1227739:HSW_RS12750
uniprot id: W8EXY3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1227739:HSW RS05050
gene id: 1227739:HSW_RS05050
uniprot id: W8F176
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1227739:HSW RS16395
gene id: 1227739:HSW_RS16395
uniprot id: W8FAG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS21575
gene id: 1227739:HSW_RS21575
uniprot id: W8F2Y9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1227739:HSW RS16005
gene id: 1227739:HSW_RS16005
uniprot id: W8EZT8
names: Similarity
messages: Belongs to the Fur family.

1227739:HSW RS15615
gene id: 1227739:HSW_RS15615
uniprot id: W8EZL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1227739:HSW RS02930
gene id: 1227739:HSW_RS02930
uniprot id: W8F255
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1227739:HSW RS21535
gene id: 1227739:HSW_RS21535
uniprot id: W8F2Y1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1227739:HSW RS18850
gene id: 1227739:HSW_RS18850
uniprot id: W8FBY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1227739:HSW RS11365
gene id: 1227739:HSW_RS11365
uniprot id: W8F0U6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS16145
gene id: 1227739:HSW_RS16145
uniprot id: W8F7P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1227739:HSW RS23850
gene id: 1227739:HSW_RS23850
uniprot id: W8FBW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1227739:HSW RS05670
gene id: 1227739:HSW_RS05670
uniprot id: W8F3Y6
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1227739:HSW RS01455
gene id: 1227739:HSW_RS01455
uniprot id: W8EV34
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1227739:HSW RS18090
gene id: 1227739:HSW_RS18090
uniprot id: W8FBJ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1227739:HSW RS06210
gene id: 1227739:HSW_RS06210
uniprot id: W8EVM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1227739:HSW RS02280
gene id: 1227739:HSW_RS02280
uniprot id: W8ERJ3
names: Similarity
messages: Belongs to the peptidase U62 family.

1227739:HSW RS00470
gene id: 1227739:HSW_RS00470
uniprot id: W8EYG4
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1227739:HSW RS10135
gene id: 1227739:HSW_RS10135
uniprot id: W8EVY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 1618 of 23S rRNA.

1227739:HSW RS08645
gene id: 1227739:HSW_RS08645
uniprot id: W8F5Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1227739:HSW RS02840
gene id: 1227739:HSW_RS02840
uniprot id: W8F228
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1227739:HSW RS16290
gene id: 1227739:HSW_RS16290
uniprot id: W8EZY5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1227739:HSW RS11470
gene id: 1227739:HSW_RS11470
uniprot id: W8F7G2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1227739:HSW RS15145
gene id: 1227739:HSW_RS15145
uniprot id: W8F778
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1227739:HSW RS13020
gene id: 1227739:HSW_RS13020
uniprot id: W8F1X4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1227739:HSW RS08880
gene id: 1227739:HSW_RS08880
uniprot id: W8EZD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS13595
gene id: 1227739:HSW_RS13595
uniprot id: W8EZQ7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1227739:HSW RS21950
gene id: 1227739:HSW_RS21950
uniprot id: W8FB29
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1227739:HSW RS16410
gene id: 1227739:HSW_RS16410
uniprot id: W8F1C4
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS15260
gene id: 1227739:HSW_RS15260
uniprot id: W8F395
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1227739:HSW RS21195
gene id: 1227739:HSW_RS21195
uniprot id: W8F6N9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1227739:HSW RS01900
gene id: 1227739:HSW_RS01900
uniprot id: W8F1I3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS07670
gene id: 1227739:HSW_RS07670
uniprot id: W8EWC8
names: Function
messages: May be involved in the biogenesis of curli organelles.

1227739:HSW RS14055
gene id: 1227739:HSW_RS14055
uniprot id: W8F2G5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1227739:HSW RS11045
gene id: 1227739:HSW_RS11045
uniprot id: W8F4Q1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome
messages: Secreted

1227739:HSW RS18085
gene id: 1227739:HSW_RS18085
uniprot id: W8F0Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1227739:HSW RS18715
gene id: 1227739:HSW_RS18715
uniprot id: W8F2L9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1227739:HSW RS01820
gene id: 1227739:HSW_RS01820
uniprot id: W8ET08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1227739:HSW RS15940
gene id: 1227739:HSW_RS15940
uniprot id: W8F133
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1227739:HSW RS05330
gene id: 1227739:HSW_RS05330
uniprot id: W8EX93
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1227739:HSW RS14410
gene id: 1227739:HSW_RS14410
uniprot id: W8F059
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

1227739:HSW RS11940
gene id: 1227739:HSW_RS11940
uniprot id: W8F178
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS09505
gene id: 1227739:HSW_RS09505
uniprot id: W8EVL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1227739:HSW RS10600
gene id: 1227739:HSW_RS10600
uniprot id: W8EWP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1227739:HSW RS08780
gene id: 1227739:HSW_RS08780
uniprot id: W8F3D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1227739:HSW RS22630
gene id: 1227739:HSW_RS22630
uniprot id: W8EYH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS04690
gene id: 1227739:HSW_RS04690
uniprot id: W8EUP3
names: Similarity
messages: Belongs to the CvfB family.

1227739:HSW RS02730
gene id: 1227739:HSW_RS02730
uniprot id: W8ERS4
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1227739:HSW RS15170
gene id: 1227739:HSW_RS15170
uniprot id: W8EZD8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1227739:HSW RS21960
gene id: 1227739:HSW_RS21960
uniprot id: W8F4E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1227739:HSW RS18750
gene id: 1227739:HSW_RS18750
uniprot id: W8FBW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1227739:HSW RS01830
gene id: 1227739:HSW_RS01830
uniprot id: W8F1G9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1227739:HSW RS02065
gene id: 1227739:HSW_RS02065
uniprot id: W8ET45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS21780
gene id: 1227739:HSW_RS21780
uniprot id: W8FAZ4
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1227739:HSW RS12370
gene id: 1227739:HSW_RS12370
uniprot id: W8F5I3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1227739:HSW RS07220
gene id: 1227739:HSW_RS07220
uniprot id: W8F2F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1227739:HSW RS03395
gene id: 1227739:HSW_RS03395
uniprot id: W8EU21
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS06410
gene id: 1227739:HSW_RS06410
uniprot id: W8EXW0
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

1227739:HSW RS10430
gene id: 1227739:HSW_RS10430
uniprot id: W8EWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS12655
gene id: 1227739:HSW_RS12655
uniprot id: W8F8A8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS21300
gene id: 1227739:HSW_RS21300
uniprot id: W8FAP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1227739:HSW RS18415
gene id: 1227739:HSW_RS18415
uniprot id: W8F2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS08885
gene id: 1227739:HSW_RS08885
uniprot id: W8EX31
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS22165
gene id: 1227739:HSW_RS22165
uniprot id: W8FB72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS01875
gene id: 1227739:HSW_RS01875
uniprot id: W8ERB3
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1227739:HSW RS09950
gene id: 1227739:HSW_RS09950
uniprot id: W8F6H1
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

1227739:HSW RS20820
gene id: 1227739:HSW_RS20820
uniprot id: W8F2J3
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

1227739:HSW RS16010
gene id: 1227739:HSW_RS16010
uniprot id: W8FA86
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1227739:HSW RS10325
gene id: 1227739:HSW_RS10325
uniprot id: W8EY07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

1227739:HSW RS21380
gene id: 1227739:HSW_RS21380
uniprot id: W8FAQ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS16035
gene id: 1227739:HSW_RS16035
uniprot id: W8F7M7
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1227739:HSW RS19820
gene id: 1227739:HSW_RS19820
uniprot id: W8F9T0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1227739:HSW RS15930
gene id: 1227739:HSW_RS15930
uniprot id: W8F7K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1227739:HSW RS19345
gene id: 1227739:HSW_RS19345
uniprot id: W8F2Y3
names: Similarity
messages: Belongs to the peptidase S66 family.

1227739:HSW RS02045
gene id: 1227739:HSW_RS02045
uniprot id: W8ERE7
names: Subcellular Location Annotation
messages: Cell inner membrane

1227739:HSW RS18875
gene id: 1227739:HSW_RS18875
uniprot id: W8FBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1227739:HSW RS13060
gene id: 1227739:HSW_RS13060
uniprot id: W8F5Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1227739:HSW RS03335
gene id: 1227739:HSW_RS03335
uniprot id: W8F099
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1227739:HSW RS04990
gene id: 1227739:HSW_RS04990
uniprot id: W8ET26
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1227739:HSW RS09445
gene id: 1227739:HSW_RS09445
uniprot id: W8F657
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS20540
gene id: 1227739:HSW_RS20540
uniprot id: W8F3M6
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS18665
gene id: 1227739:HSW_RS18665
uniprot id: W8F2K9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1227739:HSW RS18800
gene id: 1227739:HSW_RS18800
uniprot id: W8FBX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1227739:HSW RS11955
gene id: 1227739:HSW_RS11955
uniprot id: W8F7R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1227739:HSW RS02755
gene id: 1227739:HSW_RS02755
uniprot id: W8ERS8
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS20415
gene id: 1227739:HSW_RS20415
uniprot id: W8FCW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1227739:HSW RS16525
gene id: 1227739:HSW_RS16525
uniprot id: W8F7X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS01825
gene id: 1227739:HSW_RS01825
uniprot id: W8ERA4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1227739:HSW RS18775
gene id: 1227739:HSW_RS18775
uniprot id: W8FBX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1227739:HSW RS16685
gene id: 1227739:HSW_RS16685
uniprot id: W8F1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1227739:HSW RS19415
gene id: 1227739:HSW_RS19415
uniprot id: W8F5K8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1227739:HSW RS05775
gene id: 1227739:HSW_RS05775
uniprot id: W8F1N9
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

1227739:HSW RS14450
gene id: 1227739:HSW_RS14450
uniprot id: W8F2Q0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS19180
gene id: 1227739:HSW_RS19180
uniprot id: W8F2V5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1227739:HSW RS13540
gene id: 1227739:HSW_RS13540
uniprot id: W8F264
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS20670
gene id: 1227739:HSW_RS20670
uniprot id: W8F6D0
names: Similarity
messages: Belongs to the peptidase M24B family.

1227739:HSW RS21175
gene id: 1227739:HSW_RS21175
uniprot id: W8F3Y8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1227739:HSW RS04605
gene id: 1227739:HSW_RS04605
uniprot id: W8F364
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1227739:HSW RS18620
gene id: 1227739:HSW_RS18620
uniprot id: W8F189
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1227739:HSW RS20555
gene id: 1227739:HSW_RS20555
uniprot id: W8FA96
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS10560
gene id: 1227739:HSW_RS10560
uniprot id: W8F4H8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1227739:HSW RS13535
gene id: 1227739:HSW_RS13535
uniprot id: W8F666
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1227739:HSW RS10445
gene id: 1227739:HSW_RS10445
uniprot id: W8F0E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1227739:HSW RS22120
gene id: 1227739:HSW_RS22120
uniprot id: W8F779
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1227739:HSW RS11935
gene id: 1227739:HSW_RS11935
uniprot id: W8F584
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

1227739:HSW RS04840
gene id: 1227739:HSW_RS04840
uniprot id: W8ET00
names: Similarity
messages: Belongs to the AAA ATPase family.

1227739:HSW RS14435
gene id: 1227739:HSW_RS14435
uniprot id: W8EYU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1227739:HSW RS13950
gene id: 1227739:HSW_RS13950
uniprot id: W8F6E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1227739:HSW RS10215
gene id: 1227739:HSW_RS10215
uniprot id: W8F6P4
names: Similarity
messages: Belongs to the pirin family.

1227739:HSW RS02900
gene id: 1227739:HSW_RS02900
uniprot id: W8ETN4
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1227739:HSW RS23515
gene id: 1227739:HSW_RS23515
uniprot id: W8F7M3
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

1227739:HSW RS19390
gene id: 1227739:HSW_RS19390
uniprot id: W8F5K2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1227739:HSW RS05725
gene id: 1227739:HSW_RS05725
uniprot id: W8F1N4
names: Similarity
messages: Belongs to the barstar family.

1227739:HSW RS10440
gene id: 1227739:HSW_RS10440
uniprot id: W8F4G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1227739:HSW RS07015
gene id: 1227739:HSW_RS07015
uniprot id: W8F2A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1227739:HSW RS05045
gene id: 1227739:HSW_RS05045
uniprot id: W8F3F3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

1227739:HSW RS13915
gene id: 1227739:HSW_RS13915
uniprot id: W8EYJ8
names: Similarity
messages: Belongs to the peptidase M17 family.

1227739:HSW RS02845
gene id: 1227739:HSW_RS02845
uniprot id: W8EZY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1227739:HSW RS13865
gene id: 1227739:HSW_RS13865
uniprot id: W8EZW3
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03855
gene id: 1227739:HSW_RS03855
uniprot id: W8EUA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1227739:HSW RS11660
gene id: 1227739:HSW_RS11660
uniprot id: W8F113
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1227739:HSW RS09800
gene id: 1227739:HSW_RS09800
uniprot id: W8EXK8
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

1227739:HSW RS08955
gene id: 1227739:HSW_RS08955
uniprot id: W8F3G9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1227739:HSW RS05935
gene id: 1227739:HSW_RS05935
uniprot id: W8ETP4
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS19495
gene id: 1227739:HSW_RS19495
uniprot id: W8F1Q2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1227739:HSW RS19245
gene id: 1227739:HSW_RS19245
uniprot id: W8F5H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

1227739:HSW RS20665
gene id: 1227739:HSW_RS20665
uniprot id: W8FAB9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1227739:HSW RS09390
gene id: 1227739:HSW_RS09390
uniprot id: W8EVI5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS04945
gene id: 1227739:HSW_RS04945
uniprot id: W8F150
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1227739:HSW RS05635
gene id: 1227739:HSW_RS05635
uniprot id: W8EVC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1227739:HSW RS18700
gene id: 1227739:HSW_RS18700
uniprot id: W8FBV8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1227739:HSW RS14150
gene id: 1227739:HSW_RS14150
uniprot id: W8F931
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS22060
gene id: 1227739:HSW_RS22060
uniprot id: W8FDV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1227739:HSW RS18675
gene id: 1227739:HSW_RS18675
uniprot id: W8FBV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1227739:HSW RS05110
gene id: 1227739:HSW_RS05110
uniprot id: W8EUX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1227739:HSW RS01420
gene id: 1227739:HSW_RS01420
uniprot id: W8F187
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1227739:HSW RS08190
gene id: 1227739:HSW_RS08190
uniprot id: W8EUV2
names: Similarity
messages: Belongs to the PspA/IM30 family.

1227739:HSW RS17965
gene id: 1227739:HSW_RS17965
uniprot id: W8FBH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1227739:HSW RS13900
gene id: 1227739:HSW_RS13900
uniprot id: W8F6D4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1227739:HSW RS22095
gene id: 1227739:HSW_RS22095
uniprot id: W8F773
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1227739:HSW RS13100
gene id: 1227739:HSW_RS13100
uniprot id: W8EY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1227739:HSW RS04800
gene id: 1227739:HSW_RS04800
uniprot id: W8F120
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

1227739:HSW RS05495
gene id: 1227739:HSW_RS05495
uniprot id: W8F1K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1227739:HSW RS05825
gene id: 1227739:HSW_RS05825
uniprot id: W8EXL9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS10190
gene id: 1227739:HSW_RS10190
uniprot id: W8F6N7
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1227739:HSW RS16045
gene id: 1227739:HSW_RS16045
uniprot id: W8F154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1227739:HSW RS13280
gene id: 1227739:HSW_RS13280
uniprot id: W8F213
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

1227739:HSW RS05705
gene id: 1227739:HSW_RS05705
uniprot id: W8EXK4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS12060
gene id: 1227739:HSW_RS12060
uniprot id: W8F5A9
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1227739:HSW RS06310
gene id: 1227739:HSW_RS06310
uniprot id: W8EXU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS21410
gene id: 1227739:HSW_RS21410
uniprot id: W8F6S3
names: Similarity
messages: Belongs to the DinB family.

1227739:HSW RS14345
gene id: 1227739:HSW_RS14345
uniprot id: W8F972
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1227739:HSW RS18560
gene id: 1227739:HSW_RS18560
uniprot id: W8FBS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS14695
gene id: 1227739:HSW_RS14695
uniprot id: W8EZ05
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS06570
gene id: 1227739:HSW_RS06570
uniprot id: W8EXZ0
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

1227739:HSW RS18000
gene id: 1227739:HSW_RS18000
uniprot id: W8F4U3
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

1227739:HSW RS04415
gene id: 1227739:HSW_RS04415
uniprot id: W8EWP1
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

1227739:HSW RS14470
gene id: 1227739:HSW_RS14470
uniprot id: W8F2Q5
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

1227739:HSW RS04780
gene id: 1227739:HSW_RS04780
uniprot id: W8EUR0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1227739:HSW RS09130
gene id: 1227739:HSW_RS09130
uniprot id: W8EVD1
names: Similarity
messages: Belongs to the peptidase S33 family.

1227739:HSW RS19055
gene id: 1227739:HSW_RS19055
uniprot id: W8F9B6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1227739:HSW RS18625
gene id: 1227739:HSW_RS18625
uniprot id: W8FBU3
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1227739:HSW RS03625
gene id: 1227739:HSW_RS03625
uniprot id: W8EWA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1227739:HSW RS16240
gene id: 1227739:HSW_RS16240
uniprot id: W8EZX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1227739:HSW RS08530
gene id: 1227739:HSW_RS08530
uniprot id: W8EZ65
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1227739:HSW RS06960
gene id: 1227739:HSW_RS06960
uniprot id: W8EU68
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS17025
gene id: 1227739:HSW_RS17025
uniprot id: W8F486
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1227739:HSW RS16925
gene id: 1227739:HSW_RS16925
uniprot id: W8F465
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1227739:HSW RS09550
gene id: 1227739:HSW_RS09550
uniprot id: W8EXF5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1227739:HSW RS11960
gene id: 1227739:HSW_RS11960
uniprot id: W8F588
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1227739:HSW RS11390
gene id: 1227739:HSW_RS11390
uniprot id: W8F0V1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1227739:HSW RS16025
gene id: 1227739:HSW_RS16025
uniprot id: W8F3N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1227739:HSW RS15765
gene id: 1227739:HSW_RS15765
uniprot id: W8FA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1227739:HSW RS09765
gene id: 1227739:HSW_RS09765
uniprot id: W8F3Z5
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS11100
gene id: 1227739:HSW_RS11100
uniprot id: W8F0P4
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1227739:HSW RS14065
gene id: 1227739:HSW_RS14065
uniprot id: W8EYM3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1227739:HSW RS10085
gene id: 1227739:HSW_RS10085
uniprot id: W8EVX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1227739:HSW RS15760
gene id: 1227739:HSW_RS15760
uniprot id: W8EZP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1227739:HSW RS14235
gene id: 1227739:HSW_RS14235
uniprot id: W8F2K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homotetramer.

1227739:HSW RS02955
gene id: 1227739:HSW_RS02955
uniprot id: W8F260
names: Similarity
messages: Belongs to the peptidase C40 family.

1227739:HSW RS04910
gene id: 1227739:HSW_RS04910
uniprot id: W8EUT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS20660
gene id: 1227739:HSW_RS20660
uniprot id: W8F2F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1227739:HSW RS18735
gene id: 1227739:HSW_RS18735
uniprot id: W8F574
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1227739:HSW RS02295
gene id: 1227739:HSW_RS02295
uniprot id: W8EVL2
names: Similarity
messages: Belongs to the peptidase U62 family.

1227739:HSW RS06025
gene id: 1227739:HSW_RS06025
uniprot id: W8F451
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1227739:HSW RS18985
gene id: 1227739:HSW_RS18985
uniprot id: W8F2R6
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1227739:HSW RS18685
gene id: 1227739:HSW_RS18685
uniprot id: W8F565
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1227739:HSW RS12780
gene id: 1227739:HSW_RS12780
uniprot id: W8EXY9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS16270
gene id: 1227739:HSW_RS16270
uniprot id: W8FAE1
names: Similarity
messages: Belongs to the ribF family.

1227739:HSW RS18520
gene id: 1227739:HSW_RS18520
uniprot id: W8F2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1227739:HSW RS14510
gene id: 1227739:HSW_RS14510
uniprot id: W8F6R1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1227739:HSW RS04955
gene id: 1227739:HSW_RS04955
uniprot id: W8EUU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1227739:HSW RS19080
gene id: 1227739:HSW_RS19080
uniprot id: W8F9C1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS02890
gene id: 1227739:HSW_RS02890
uniprot id: W8EZZ2
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1227739:HSW RS07595
gene id: 1227739:HSW_RS07595
uniprot id: W8EWB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1227739:HSW RS06050
gene id: 1227739:HSW_RS06050
uniprot id: W8F456
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1227739:HSW RS15420
gene id: 1227739:HSW_RS15420
uniprot id: W8F7C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1227739:HSW RS06875
gene id: 1227739:HSW_RS06875
uniprot id: W8EY49
names: Similarity
messages: Belongs to the thioredoxin family.

1227739:HSW RS07800
gene id: 1227739:HSW_RS07800
uniprot id: W8EYR1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1227739:HSW RS13390
gene id: 1227739:HSW_RS13390
uniprot id: W8F234
names: Similarity
messages: Belongs to the DEAD box helicase family.

1227739:HSW RS06390
gene id: 1227739:HSW_RS06390
uniprot id: W8EVQ3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1227739:HSW RS07235
gene id: 1227739:HSW_RS07235
uniprot id: W8EUB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1227739:HSW RS05385
gene id: 1227739:HSW_RS05385
uniprot id: W8ETB0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1227739:HSW RS09360
gene id: 1227739:HSW_RS09360
uniprot id: W8EZN7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1227739:HSW RS18645
gene id: 1227739:HSW_RS18645
uniprot id: W8F195
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1227739:HSW RS21640
gene id: 1227739:HSW_RS21640
uniprot id: W8F6X5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1227739:HSW RS21420
gene id: 1227739:HSW_RS21420
uniprot id: W8F2W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

1227739:HSW RS07745
gene id: 1227739:HSW_RS07745
uniprot id: W8F556
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1227739:HSW RS16640
gene id: 1227739:HSW_RS16640
uniprot id: W8FAM3
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1227739:HSW RS21730
gene id: 1227739:HSW_RS21730
uniprot id: W8FAY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1227739:HSW RS11380
gene id: 1227739:HSW_RS11380
uniprot id: W8F7E5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1227739:HSW RS16460
gene id: 1227739:HSW_RS16460
uniprot id: W8F1D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1227739:HSW RS12500
gene id: 1227739:HSW_RS12500
uniprot id: W8F1I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1227739:HSW RS16520
gene id: 1227739:HSW_RS16520
uniprot id: W8FAJ8
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS21890
gene id: 1227739:HSW_RS21890
uniprot id: W8F349
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1227739:HSW RS05325
gene id: 1227739:HSW_RS05325
uniprot id: W8F1D7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1227739:HSW RS03470
gene id: 1227739:HSW_RS03470
uniprot id: W8F0B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1227739:HSW RS04055
gene id: 1227739:HSW_RS04055
uniprot id: W8ESK3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1227739:HSW RS07990
gene id: 1227739:HSW_RS07990
uniprot id: W8EWL6
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1227739:HSW RS18820
gene id: 1227739:HSW_RS18820
uniprot id: W8F1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1227739:HSW RS16880
gene id: 1227739:HSW_RS16880
uniprot id: W8F455
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1227739:HSW RS03235
gene id: 1227739:HSW_RS03235
uniprot id: W8F086
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1227739:HSW RS11325
gene id: 1227739:HSW_RS11325
uniprot id: W8EX36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1227739:HSW RS05080
gene id: 1227739:HSW_RS05080
uniprot id: W8EX37
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS03085
gene id: 1227739:HSW_RS03085
uniprot id: W8F2C3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS05770
gene id: 1227739:HSW_RS05770
uniprot id: W8F404
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome
messages: Secreted

1227739:HSW RS08765
gene id: 1227739:HSW_RS08765
uniprot id: W8EX09
names: Similarity
messages: Belongs to the TrpF family.

1227739:HSW RS00950
gene id: 1227739:HSW_RS00950
uniprot id: W8EQS5
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS16575
gene id: 1227739:HSW_RS16575
uniprot id: W8F3Z1
names: Cofactor
messages: Can also use Mn(2+) ion.

1227739:HSW RS21675
gene id: 1227739:HSW_RS21675
uniprot id: W8F308
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS06565
gene id: 1227739:HSW_RS06565
uniprot id: W8F215
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03550
gene id: 1227739:HSW_RS03550
uniprot id: W8EU49
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1227739:HSW RS13235
gene id: 1227739:HSW_RS13235
uniprot id: W8F8K5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1227739:HSW RS02010
gene id: 1227739:HSW_RS02010
uniprot id: W8EVE9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS10000
gene id: 1227739:HSW_RS10000
uniprot id: W8EXQ8
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS09095
gene id: 1227739:HSW_RS09095
uniprot id: W8F3K0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1227739:HSW RS12435
gene id: 1227739:HSW_RS12435
uniprot id: W8EXP7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS15175
gene id: 1227739:HSW_RS15175
uniprot id: W8F9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Cell wall formation.
messages: Cytoplasm

1227739:HSW RS13935
gene id: 1227739:HSW_RS13935
uniprot id: W8EZX7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1227739:HSW RS14880
gene id: 1227739:HSW_RS14880
uniprot id: W8EZ46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1227739:HSW RS18795
gene id: 1227739:HSW_RS18795
uniprot id: W8F1C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1227739:HSW RS07320
gene id: 1227739:HSW_RS07320
uniprot id: W8EYE5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1227739:HSW RS04240
gene id: 1227739:HSW_RS04240
uniprot id: W8ESN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1227739:HSW RS05505
gene id: 1227739:HSW_RS05505
uniprot id: W8EV99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1227739:HSW RS14485
gene id: 1227739:HSW_RS14485
uniprot id: W8F9A4
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS21590
gene id: 1227739:HSW_RS21590
uniprot id: W8F6W4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1227739:HSW RS19385
gene id: 1227739:HSW_RS19385
uniprot id: W8F9J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1227739:HSW RS11740
gene id: 1227739:HSW_RS11740
uniprot id: W8EXB1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS07200
gene id: 1227739:HSW_RS07200
uniprot id: W8EYB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1227739:HSW RS02165
gene id: 1227739:HSW_RS02165
uniprot id: W8ET63
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1227739:HSW RS06945
gene id: 1227739:HSW_RS06945
uniprot id: W8F295
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1227739:HSW RS07555
gene id: 1227739:HSW_RS07555
uniprot id: W8EWA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1227739:HSW RS06730
gene id: 1227739:HSW_RS06730
uniprot id: W8EU27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1227739:HSW RS16920
gene id: 1227739:HSW_RS16920
uniprot id: W8F863
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1227739:HSW RS22655
gene id: 1227739:HSW_RS22655
uniprot id: W8EUQ8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

1227739:HSW RS15755
gene id: 1227739:HSW_RS15755
uniprot id: W8F3H3
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1227739:HSW RS09070
gene id: 1227739:HSW_RS09070
uniprot id: W8EZH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS22665
gene id: 1227739:HSW_RS22665
uniprot id: W8EUT4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1227739:HSW RS02035
gene id: 1227739:HSW_RS02035
uniprot id: W8EVF5
names: Function
names: Similarity
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

1227739:HSW RS14700
gene id: 1227739:HSW_RS14700
uniprot id: W8F6V1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1227739:HSW RS15405
gene id: 1227739:HSW_RS15405
uniprot id: W8F3B5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1227739:HSW RS11765
gene id: 1227739:HSW_RS11765
uniprot id: W8EXB6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1227739:HSW RS11925
gene id: 1227739:HSW_RS11925
uniprot id: W8EXE9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1227739:HSW RS08240
gene id: 1227739:HSW_RS08240
uniprot id: W8EWR3
names: Subcellular Location Annotation
messages: Cytoplasm

1227739:HSW RS02290
gene id: 1227739:HSW_RS02290
uniprot id: W8EZJ9
names: Similarity
messages: Belongs to the peptidase U62 family.

1227739:HSW RS04340
gene id: 1227739:HSW_RS04340
uniprot id: W8EWM5
names: Similarity
messages: Belongs to the pirin family.

1227739:HSW RS16400
gene id: 1227739:HSW_RS16400
uniprot id: W8F7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS18240
gene id: 1227739:HSW_RS18240
uniprot id: W8F2D1
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1227739:HSW RS03145
gene id: 1227739:HSW_RS03145
uniprot id: W8EW41
names: Similarity
messages: Belongs to the Skp family.

1227739:HSW RS05030
gene id: 1227739:HSW_RS05030
uniprot id: W8EX28
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS01545
gene id: 1227739:HSW_RS01545
uniprot id: W8ESV9
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

1227739:HSW RS06550
gene id: 1227739:HSW_RS06550
uniprot id: W8EVT3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1227739:HSW RS20635
gene id: 1227739:HSW_RS20635
uniprot id: W8F2F4
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1227739:HSW RS03385
gene id: 1227739:HSW_RS03385
uniprot id: W8F0A4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1227739:HSW RS09860
gene id: 1227739:HSW_RS09860
uniprot id: W8F415
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS13625
gene id: 1227739:HSW_RS13625
uniprot id: W8F8T5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03210
gene id: 1227739:HSW_RS03210
uniprot id: W8F082
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1227739:HSW RS05565
gene id: 1227739:HSW_RS05565
uniprot id: W8F3W9
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-II family.

1227739:HSW RS11835
gene id: 1227739:HSW_RS11835
uniprot id: W8F7P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1227739:HSW RS08835
gene id: 1227739:HSW_RS08835
uniprot id: W8EZC0
names: Similarity
messages: Belongs to the DNA photolyase family.

1227739:HSW RS20575
gene id: 1227739:HSW_RS20575
uniprot id: W8FCZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1227739:HSW RS08755
gene id: 1227739:HSW_RS08755
uniprot id: W8F3D4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS04950
gene id: 1227739:HSW_RS04950
uniprot id: W8EX11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1227739:HSW RS07260
gene id: 1227739:HSW_RS07260
uniprot id: W8F4T6
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

1227739:HSW RS08090
gene id: 1227739:HSW_RS08090
uniprot id: W8F5G0
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1227739:HSW RS08515
gene id: 1227739:HSW_RS08515
uniprot id: W8EV15
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1227739:HSW RS14375
gene id: 1227739:HSW_RS14375
uniprot id: W8F6M9
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS03545
gene id: 1227739:HSW_RS03545
uniprot id: W8EW95
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1227739:HSW RS02690
gene id: 1227739:HSW_RS02690
uniprot id: W8F1Z4
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS12700
gene id: 1227739:HSW_RS12700
uniprot id: W8F8B6
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS15050
gene id: 1227739:HSW_RS15050
uniprot id: W8F367
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

1227739:HSW RS14705
gene id: 1227739:HSW_RS14705
uniprot id: W8F2V9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS09560
gene id: 1227739:HSW_RS09560
uniprot id: W8F684
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS22525
gene id: 1227739:HSW_RS22525
uniprot id: W8F3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1227739:HSW RS21630
gene id: 1227739:HSW_RS21630
uniprot id: W8FDK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS04395
gene id: 1227739:HSW_RS04395
uniprot id: W8EUJ1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1227739:HSW RS07070
gene id: 1227739:HSW_RS07070
uniprot id: W8F2B9
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1227739:HSW RS01610
gene id: 1227739:HSW_RS01610
uniprot id: W8ESX3
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS16770
gene id: 1227739:HSW_RS16770
uniprot id: W8F066
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1227739:HSW RS03990
gene id: 1227739:HSW_RS03990
uniprot id: W8F2U7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1227739:HSW RS11020
gene id: 1227739:HSW_RS11020
uniprot id: W8F4P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1227739:HSW RS13470
gene id: 1227739:HSW_RS13470
uniprot id: W8EZN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1227739:HSW RS13550
gene id: 1227739:HSW_RS13550
uniprot id: W8EYD2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS22350
gene id: 1227739:HSW_RS22350
uniprot id: W8F161
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS21865
gene id: 1227739:HSW_RS21865
uniprot id: W8F345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1227739:HSW RS10375
gene id: 1227739:HSW_RS10375
uniprot id: W8EY16
names: Similarity
messages: Belongs to the SCO1/2 family.

1227739:HSW RS09150
gene id: 1227739:HSW_RS09150
uniprot id: W8EX75
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS07650
gene id: 1227739:HSW_RS07650
uniprot id: W8EUI4
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1227739:HSW RS01540
gene id: 1227739:HSW_RS01540
uniprot id: W8EV52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS10990
gene id: 1227739:HSW_RS10990
uniprot id: W8EWX1
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS08775
gene id: 1227739:HSW_RS08775
uniprot id: W8F5S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1227739:HSW RS06415
gene id: 1227739:HSW_RS06415
uniprot id: W8ETW5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

1227739:HSW RS14020
gene id: 1227739:HSW_RS14020
uniprot id: W8F903
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1227739:HSW RS22765
gene id: 1227739:HSW_RS22765
uniprot id: W8F6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1227739:HSW RS13525
gene id: 1227739:HSW_RS13525
uniprot id: W8EYC7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1227739:HSW RS01850
gene id: 1227739:HSW_RS01850
uniprot id: W8ERA8
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1227739:HSW RS04820
gene id: 1227739:HSW_RS04820
uniprot id: W8ESZ7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1227739:HSW RS16140
gene id: 1227739:HSW_RS16140
uniprot id: W8FAB2
names: Similarity
messages: Belongs to the DapB family.

1227739:HSW RS11285
gene id: 1227739:HSW_RS11285
uniprot id: W8F4V2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS04180
gene id: 1227739:HSW_RS04180
uniprot id: W8EUF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1227739:HSW RS03305
gene id: 1227739:HSW_RS03305
uniprot id: W8F2G7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1227739:HSW RS09640
gene id: 1227739:HSW_RS09640
uniprot id: W8F6A0
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

1227739:HSW RS09540
gene id: 1227739:HSW_RS09540
uniprot id: W8F3U5
names: Subcellular Location Annotation
messages: Cell inner membrane

1227739:HSW RS18925
gene id: 1227739:HSW_RS18925
uniprot id: W8F989
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1227739:HSW RS02535
gene id: 1227739:HSW_RS02535
uniprot id: W8ETD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1227739:HSW RS10040
gene id: 1227739:HSW_RS10040
uniprot id: W8F457
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 20 family.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

1227739:HSW RS13575
gene id: 1227739:HSW_RS13575
uniprot id: W8EYD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1227739:HSW RS15095
gene id: 1227739:HSW_RS15095
uniprot id: W8F770
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

1227739:HSW RS13990
gene id: 1227739:HSW_RS13990
uniprot id: W8EYL1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1227739:HSW RS02130
gene id: 1227739:HSW_RS02130
uniprot id: W8EZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1227739:HSW RS13515
gene id: 1227739:HSW_RS13515
uniprot id: W8F259
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS21280
gene id: 1227739:HSW_RS21280
uniprot id: W8F6Q2
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS12930
gene id: 1227739:HSW_RS12930
uniprot id: W8EY19
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS21445
gene id: 1227739:HSW_RS21445
uniprot id: W8F2W4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS10260
gene id: 1227739:HSW_RS10260
uniprot id: W8F6T5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS18855
gene id: 1227739:HSW_RS18855
uniprot id: W8F980
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1227739:HSW RS10300
gene id: 1227739:HSW_RS10300
uniprot id: W8EY01
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1227739:HSW RS07770
gene id: 1227739:HSW_RS07770
uniprot id: W8F562
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1227739:HSW RS13475
gene id: 1227739:HSW_RS13475
uniprot id: W8EYB8
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS15515
gene id: 1227739:HSW_RS15515
uniprot id: W8F3D5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1227739:HSW RS04615
gene id: 1227739:HSW_RS04615
uniprot id: W8EUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1227739:HSW RS01535
gene id: 1227739:HSW_RS01535
uniprot id: W8EZ35
names: Similarity
messages: Belongs to the threonine synthase family.

1227739:HSW RS03300
gene id: 1227739:HSW_RS03300
uniprot id: W8ES68
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1227739:HSW RS09435
gene id: 1227739:HSW_RS09435
uniprot id: W8EZQ3
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1227739:HSW RS21690
gene id: 1227739:HSW_RS21690
uniprot id: W8F6Y4
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

1227739:HSW RS01865
gene id: 1227739:HSW_RS01865
uniprot id: W8EVB8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1227739:HSW RS20590
gene id: 1227739:HSW_RS20590
uniprot id: W8F3N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1227739:HSW RS02335
gene id: 1227739:HSW_RS02335
uniprot id: W8EZL1
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS07875
gene id: 1227739:HSW_RS07875
uniprot id: W8EYU7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS19295
gene id: 1227739:HSW_RS19295
uniprot id: W8F5I2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1227739:HSW RS22440
gene id: 1227739:HSW_RS22440
uniprot id: W8EVR2
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

1227739:HSW RS16315
gene id: 1227739:HSW_RS16315
uniprot id: W8EZZ1
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS14835
gene id: 1227739:HSW_RS14835
uniprot id: W8F9J6
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1227739:HSW RS16150
gene id: 1227739:HSW_RS16150
uniprot id: W8F3R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1227739:HSW RS21330
gene id: 1227739:HSW_RS21330
uniprot id: W8F6Q9
names: Similarity
messages: Belongs to the NusB family.

1227739:HSW RS19985
gene id: 1227739:HSW_RS19985
uniprot id: W8FA03
names: Similarity
messages: Belongs to the peptidase C56 family.

1227739:HSW RS13035
gene id: 1227739:HSW_RS13035
uniprot id: W8F8H3
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS16955
gene id: 1227739:HSW_RS16955
uniprot id: W8F1M6
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cell membrane
messages: Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.

1227739:HSW RS09160
gene id: 1227739:HSW_RS09160
uniprot id: W8F5Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1227739:HSW RS17330
gene id: 1227739:HSW_RS17330
uniprot id: W8F0I2
names: Similarity
messages: Belongs to the thioredoxin family.

1227739:HSW RS23550
gene id: 1227739:HSW_RS23550
uniprot id: W8F045
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

1227739:HSW RS11360
gene id: 1227739:HSW_RS11360
uniprot id: W8F4W5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS18745
gene id: 1227739:HSW_RS18745
uniprot id: W8F1B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1227739:HSW RS12375
gene id: 1227739:HSW_RS12375
uniprot id: W8F1G7
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1227739:HSW RS01815
gene id: 1227739:HSW_RS01815
uniprot id: W8EVA9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1227739:HSW RS14310
gene id: 1227739:HSW_RS14310
uniprot id: W8F041
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS14320
gene id: 1227739:HSW_RS14320
uniprot id: W8F967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1227739:HSW RS14000
gene id: 1227739:HSW_RS14000
uniprot id: W8F6F1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS01585
gene id: 1227739:HSW_RS01585
uniprot id: W8ESW9
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1227739:HSW RS02820
gene id: 1227739:HSW_RS02820
uniprot id: W8EVW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1227739:HSW RS09040
gene id: 1227739:HSW_RS09040
uniprot id: W8EVB0
names: Similarity
messages: Belongs to the aspartokinase family.

1227739:HSW RS16420
gene id: 1227739:HSW_RS16420
uniprot id: W8FAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

1227739:HSW RS18710
gene id: 1227739:HSW_RS18710
uniprot id: W8F569
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1227739:HSW RS14855
gene id: 1227739:HSW_RS14855
uniprot id: W8EZ41
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1227739:HSW RS11245
gene id: 1227739:HSW_RS11245
uniprot id: W8EYH3
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS20270
gene id: 1227739:HSW_RS20270
uniprot id: W8FCU0
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1227739:HSW RS10110
gene id: 1227739:HSW_RS10110
uniprot id: W8EVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1227739:HSW RS06005
gene id: 1227739:HSW_RS06005
uniprot id: W8F1S6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS10065
gene id: 1227739:HSW_RS10065
uniprot id: W8F6K6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1227739:HSW RS06810
gene id: 1227739:HSW_RS06810
uniprot id: W8F4I8
names: Similarity
messages: Belongs to the CarB family.

1227739:HSW RS20965
gene id: 1227739:HSW_RS20965
uniprot id: W8FD66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1227739:HSW RS11575
gene id: 1227739:HSW_RS11575
uniprot id: W8EX80
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1227739:HSW RS06610
gene id: 1227739:HSW_RS06610
uniprot id: W8F4F4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS17410
gene id: 1227739:HSW_RS17410
uniprot id: W8F8I3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1227739:HSW RS15715
gene id: 1227739:HSW_RS15715
uniprot id: W8F0Y5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS21035
gene id: 1227739:HSW_RS21035
uniprot id: W8F2N7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1227739:HSW RS13700
gene id: 1227739:HSW_RS13700
uniprot id: W8F8U7
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS09490
gene id: 1227739:HSW_RS09490
uniprot id: W8F667
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1227739:HSW RS05615
gene id: 1227739:HSW_RS05615
uniprot id: W8ETJ1
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS18690
gene id: 1227739:HSW_RS18690
uniprot id: W8F2L4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1227739:HSW RS17360
gene id: 1227739:HSW_RS17360
uniprot id: W8FB32
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS10075
gene id: 1227739:HSW_RS10075
uniprot id: W8F043
names: Similarity
messages: Belongs to the SUI1 family.

1227739:HSW RS13275
gene id: 1227739:HSW_RS13275
uniprot id: W8F8L4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

1227739:HSW RS05630
gene id: 1227739:HSW_RS05630
uniprot id: W8EXJ1
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1227739:HSW RS19745
gene id: 1227739:HSW_RS19745
uniprot id: W8F5S7
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1227739:HSW RS05930
gene id: 1227739:HSW_RS05930
uniprot id: W8EVH2
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1227739:HSW RS08970
gene id: 1227739:HSW_RS08970
uniprot id: W8EV96
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03980
gene id: 1227739:HSW_RS03980
uniprot id: W8EUC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS00450
gene id: 1227739:HSW_RS00450
uniprot id: W8EYF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1227739:HSW RS14390
gene id: 1227739:HSW_RS14390
uniprot id: W8EYT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1227739:HSW RS15580
gene id: 1227739:HSW_RS15580
uniprot id: W8F7E7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS13505
gene id: 1227739:HSW_RS13505
uniprot id: W8F8R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1227739:HSW RS11560
gene id: 1227739:HSW_RS11560
uniprot id: W8F503
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS18320
gene id: 1227739:HSW_RS18320
uniprot id: W8F139
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1227739:HSW RS01075
gene id: 1227739:HSW_RS01075
uniprot id: W8EUU9
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1227739:HSW RS15520
gene id: 1227739:HSW_RS15520
uniprot id: W8F0U8
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS10565
gene id: 1227739:HSW_RS10565
uniprot id: W8F0G1
names: Similarity
messages: Belongs to the CinA family.

1227739:HSW RS04725
gene id: 1227739:HSW_RS04725
uniprot id: W8EWW4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1227739:HSW RS03875
gene id: 1227739:HSW_RS03875
uniprot id: W8EWE5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS09990
gene id: 1227739:HSW_RS09990
uniprot id: W8EVV0
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS15055
gene id: 1227739:HSW_RS15055
uniprot id: W8F0L6
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1227739:HSW RS13025
gene id: 1227739:HSW_RS13025
uniprot id: W8EZE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1227739:HSW RS03630
gene id: 1227739:HSW_RS03630
uniprot id: W8EU64
names: Similarity
messages: Belongs to the peptidase S41A family.

1227739:HSW RS12975
gene id: 1227739:HSW_RS12975
uniprot id: W8EY27
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1227739:HSW RS20100
gene id: 1227739:HSW_RS20100
uniprot id: W8FCR5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1227739:HSW RS22020
gene id: 1227739:HSW_RS22020
uniprot id: W8F755
names: Similarity
messages: Belongs to the RecJ family.

1227739:HSW RS16625
gene id: 1227739:HSW_RS16625
uniprot id: W8F402
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1227739:HSW RS17315
gene id: 1227739:HSW_RS17315
uniprot id: W8F8E3
names: Similarity
messages: Belongs to the GbsR family.

1227739:HSW RS19360
gene id: 1227739:HSW_RS19360
uniprot id: W8F9I4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1227739:HSW RS16455
gene id: 1227739:HSW_RS16455
uniprot id: W8F3W6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1227739:HSW RS01460
gene id: 1227739:HSW_RS01460
uniprot id: W8ESU0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1227739:HSW RS20800
gene id: 1227739:HSW_RS20800
uniprot id: W8FD35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS11355
gene id: 1227739:HSW_RS11355
uniprot id: W8F7E0
names: Similarity
messages: Belongs to the citrate synthase family.

1227739:HSW RS24925
gene id: 1227739:HSW_RS24925
uniprot id: W8ERK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS25010
gene id: 1227739:HSW_RS25010
uniprot id: W8F672
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

1227739:HSW RS20845
gene id: 1227739:HSW_RS20845
uniprot id: W8F2J8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1227739:HSW RS04530
gene id: 1227739:HSW_RS04530
uniprot id: W8ESU7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1227739:HSW RS11455
gene id: 1227739:HSW_RS11455
uniprot id: W8F0W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

1227739:HSW RS18930
gene id: 1227739:HSW_RS18930
uniprot id: W8F5A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1227739:HSW RS10820
gene id: 1227739:HSW_RS10820
uniprot id: W8EY95
names: Similarity
messages: Belongs to the LOG family.

1227739:HSW RS02125
gene id: 1227739:HSW_RS02125
uniprot id: W8F1M3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1227739:HSW RS04090
gene id: 1227739:HSW_RS04090
uniprot id: W8F0L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1227739:HSW RS16230
gene id: 1227739:HSW_RS16230
uniprot id: W8F3S4
names: Similarity
messages: Belongs to the peptidase C40 family.

1227739:HSW RS07085
gene id: 1227739:HSW_RS07085
uniprot id: W8EU90
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS14215
gene id: 1227739:HSW_RS14215
uniprot id: W8F025
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

1227739:HSW RS04360
gene id: 1227739:HSW_RS04360
uniprot id: W8F0S0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1227739:HSW RS05315
gene id: 1227739:HSW_RS05315
uniprot id: W8ET94
names: Similarity
messages: Belongs to the asparagine synthetase family.

1227739:HSW RS08035
gene id: 1227739:HSW_RS08035
uniprot id: W8EWM3
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1227739:HSW RS18885
gene id: 1227739:HSW_RS18885
uniprot id: W8F984
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1227739:HSW RS16495
gene id: 1227739:HSW_RS16495
uniprot id: W8FAJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1227739:HSW RS17845
gene id: 1227739:HSW_RS17845
uniprot id: W8FBF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1227739:HSW RS09885
gene id: 1227739:HSW_RS09885
uniprot id: W8F006
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS20650
gene id: 1227739:HSW_RS20650
uniprot id: W8F6C5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

1227739:HSW RS18530
gene id: 1227739:HSW_RS18530
uniprot id: W8F170
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1227739:HSW RS11735
gene id: 1227739:HSW_RS11735
uniprot id: W8EYQ6
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1227739:HSW RS20735
gene id: 1227739:HSW_RS20735
uniprot id: W8FAD4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1227739:HSW RS12410
gene id: 1227739:HSW_RS12410
uniprot id: W8EXP1
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1227739:HSW RS08850
gene id: 1227739:HSW_RS08850
uniprot id: W8F5U2
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1227739:HSW RS20440
gene id: 1227739:HSW_RS20440
uniprot id: W8FCX0
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS07590
gene id: 1227739:HSW_RS07590
uniprot id: W8EYL2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS00475
gene id: 1227739:HSW_RS00475
uniprot id: W8EUE6
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1227739:HSW RS10155
gene id: 1227739:HSW_RS10155
uniprot id: W8EXT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1227739:HSW RS00395
gene id: 1227739:HSW_RS00395
uniprot id: W8EYE7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS13580
gene id: 1227739:HSW_RS13580
uniprot id: W8F8S7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1227739:HSW RS18805
gene id: 1227739:HSW_RS18805
uniprot id: W8F971
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1227739:HSW RS12680
gene id: 1227739:HSW_RS12680
uniprot id: W8F8B2
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1227739:HSW RS06740
gene id: 1227739:HSW_RS06740
uniprot id: W8F251
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1227739:HSW RS17020
gene id: 1227739:HSW_RS17020
uniprot id: W8F880
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1227739:HSW RS22075
gene id: 1227739:HSW_RS22075
uniprot id: W8F4H1
names: Similarity
messages: Belongs to the RutC family.

1227739:HSW RS17795
gene id: 1227739:HSW_RS17795
uniprot id: W8F0U0
names: Subcellular Location Annotation
messages: Cytoplasm

1227739:HSW RS21655
gene id: 1227739:HSW_RS21655
uniprot id: W8FDK9
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1227739:HSW RS11915
gene id: 1227739:HSW_RS11915
uniprot id: W8F172
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1227739:HSW RS09065
gene id: 1227739:HSW_RS09065
uniprot id: W8F3J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS17320
gene id: 1227739:HSW_RS17320
uniprot id: W8F4E3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1227739:HSW RS20925
gene id: 1227739:HSW_RS20925
uniprot id: W8FD58
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1227739:HSW RS20455
gene id: 1227739:HSW_RS20455
uniprot id: W8F3K9
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

1227739:HSW RS06230
gene id: 1227739:HSW_RS06230
uniprot id: W8EXT5
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1227739:HSW RS04775
gene id: 1227739:HSW_RS04775
uniprot id: W8EWX5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS14275
gene id: 1227739:HSW_RS14275
uniprot id: W8F957
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

1227739:HSW RS03330
gene id: 1227739:HSW_RS03330
uniprot id: W8F2H2
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS00445
gene id: 1227739:HSW_RS00445
uniprot id: W8F0J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1227739:HSW RS05515
gene id: 1227739:HSW_RS05515
uniprot id: W8F3W0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS09485
gene id: 1227739:HSW_RS09485
uniprot id: W8EXE2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1227739:HSW RS08250
gene id: 1227739:HSW_RS08250
uniprot id: W8F5I9
names: Similarity
messages: Belongs to the MQO family.

1227739:HSW RS22130
gene id: 1227739:HSW_RS22130
uniprot id: W8F3A3
names: Caution
names: Function
names: Similarity
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).

1227739:HSW RS07730
gene id: 1227739:HSW_RS07730
uniprot id: W8EYP2
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1227739:HSW RS14670
gene id: 1227739:HSW_RS14670
uniprot id: W8EYZ8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1227739:HSW RS05035
gene id: 1227739:HSW_RS05035
uniprot id: W8EUW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1227739:HSW RS20445
gene id: 1227739:HSW_RS20445
uniprot id: W8FA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS07455
gene id: 1227739:HSW_RS07455
uniprot id: W8F2L0
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS18920
gene id: 1227739:HSW_RS18920
uniprot id: W8FC00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1227739:HSW RS19380
gene id: 1227739:HSW_RS19380
uniprot id: W8FC92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1227739:HSW RS16245
gene id: 1227739:HSW_RS16245
uniprot id: W8FAD5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03845
gene id: 1227739:HSW_RS03845
uniprot id: W8F0I0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1227739:HSW RS18740
gene id: 1227739:HSW_RS18740
uniprot id: W8F2M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1227739:HSW RS13730
gene id: 1227739:HSW_RS13730
uniprot id: W8F6A4
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS00510
gene id: 1227739:HSW_RS00510
uniprot id: W8F0K6
names: Similarity
messages: Belongs to the AHA1 family.

1227739:HSW RS06630
gene id: 1227739:HSW_RS06630
uniprot id: W8EU08
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1227739:HSW RS21660
gene id: 1227739:HSW_RS21660
uniprot id: W8FAW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

1227739:HSW RS01520
gene id: 1227739:HSW_RS01520
uniprot id: W8ESV4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1227739:HSW RS06520
gene id: 1227739:HSW_RS06520
uniprot id: W8F207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

1227739:HSW RS08875
gene id: 1227739:HSW_RS08875
uniprot id: W8F3F7
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1227739:HSW RS17005
gene id: 1227739:HSW_RS17005
uniprot id: W8F1N5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS19485
gene id: 1227739:HSW_RS19485
uniprot id: W8F5M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1227739:HSW RS03015
gene id: 1227739:HSW_RS03015
uniprot id: W8F050
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

1227739:HSW RS05970
gene id: 1227739:HSW_RS05970
uniprot id: W8ETP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1227739:HSW RS18905
gene id: 1227739:HSW_RS18905
uniprot id: W8F5A1
names: Similarity
messages: Belongs to the peptidase M1 family.

1227739:HSW RS18940
gene id: 1227739:HSW_RS18940
uniprot id: W8F1F1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS20710
gene id: 1227739:HSW_RS20710
uniprot id: W8FAC9
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS20010
gene id: 1227739:HSW_RS20010
uniprot id: W8FA07
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1227739:HSW RS22025
gene id: 1227739:HSW_RS22025
uniprot id: W8F4G2
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS06680
gene id: 1227739:HSW_RS06680
uniprot id: W8EVV6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS11950
gene id: 1227739:HSW_RS11950
uniprot id: W8EXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1227739:HSW RS11370
gene id: 1227739:HSW_RS11370
uniprot id: W8EYJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1227739:HSW RS15440
gene id: 1227739:HSW_RS15440
uniprot id: W8F7C7
names: Similarity
messages: Belongs to the threonine aldolase family.

1227739:HSW RS05275
gene id: 1227739:HSW_RS05275
uniprot id: W8EV17
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1227739:HSW RS16930
gene id: 1227739:HSW_RS16930
uniprot id: W8F1M1
names: Subcellular Location Annotation
messages: Cytoplasm

1227739:HSW RS10315
gene id: 1227739:HSW_RS10315
uniprot id: W8F4E1
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1227739:HSW RS16950
gene id: 1227739:HSW_RS16950
uniprot id: W8F470
names: Similarity
messages: Belongs to the UPF0162 family.

1227739:HSW RS16235
gene id: 1227739:HSW_RS16235
uniprot id: W8F194
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1227739:HSW RS11650
gene id: 1227739:HSW_RS11650
uniprot id: W8EX91
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS20520
gene id: 1227739:HSW_RS20520
uniprot id: W8F2D2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS04855
gene id: 1227739:HSW_RS04855
uniprot id: W8EWZ1
names: Similarity
messages: Belongs to the UPF0235 family.

1227739:HSW RS08805
gene id: 1227739:HSW_RS08805
uniprot id: W8F3E3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

1227739:HSW RS09825
gene id: 1227739:HSW_RS09825
uniprot id: W8EVS2
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1227739:HSW RS06790
gene id: 1227739:HSW_RS06790
uniprot id: W8F263
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1227739:HSW RS03075
gene id: 1227739:HSW_RS03075
uniprot id: W8ETW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

1227739:HSW RS19845
gene id: 1227739:HSW_RS19845
uniprot id: W8F9T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS04620
gene id: 1227739:HSW_RS04620
uniprot id: W8ESW5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1227739:HSW RS04980
gene id: 1227739:HSW_RS04980
uniprot id: W8EX17
names: Similarity
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

1227739:HSW RS17150
gene id: 1227739:HSW_RS17150
uniprot id: W8F0E4
names: Similarity
messages: In the N-terminal section; belongs to the phytochrome family.

1227739:HSW RS21250
gene id: 1227739:HSW_RS21250
uniprot id: W8F403
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1227739:HSW RS04275
gene id: 1227739:HSW_RS04275
uniprot id: W8EUH2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1227739:HSW RS15905
gene id: 1227739:HSW_RS15905
uniprot id: W8FA74
names: Similarity
messages: Belongs to the arginase family.

1227739:HSW RS08920
gene id: 1227739:HSW_RS08920
uniprot id: W8F5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS15875
gene id: 1227739:HSW_RS15875
uniprot id: W8F118
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1227739:HSW RS02685
gene id: 1227739:HSW_RS02685
uniprot id: W8ETH8
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS02880
gene id: 1227739:HSW_RS02880
uniprot id: W8ERV4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS22890
gene id: 1227739:HSW_RS22890
uniprot id: W8EZK3
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS12705
gene id: 1227739:HSW_RS12705
uniprot id: W8F5T6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

1227739:HSW RS05610
gene id: 1227739:HSW_RS05610
uniprot id: W8EVB5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS19710
gene id: 1227739:HSW_RS19710
uniprot id: W8FCG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1227739:HSW RS09585
gene id: 1227739:HSW_RS09585
uniprot id: W8F689
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS06755
gene id: 1227739:HSW_RS06755
uniprot id: W8EU32
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1227739:HSW RS08980
gene id: 1227739:HSW_RS08980
uniprot id: W8F3H4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1227739:HSW RS20420
gene id: 1227739:HSW_RS20420
uniprot id: W8FA76
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1227739:HSW RS11395
gene id: 1227739:HSW_RS11395
uniprot id: W8EYJ6
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1227739:HSW RS14955
gene id: 1227739:HSW_RS14955
uniprot id: W8F712
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS07985
gene id: 1227739:HSW_RS07985
uniprot id: W8F309
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1227739:HSW RS06970
gene id: 1227739:HSW_RS06970
uniprot id: W8F299
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1227739:HSW RS04555
gene id: 1227739:HSW_RS04555
uniprot id: W8ESV2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1227739:HSW RS04010
gene id: 1227739:HSW_RS04010
uniprot id: W8F2V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1227739:HSW RS16465
gene id: 1227739:HSW_RS16465
uniprot id: W8F016
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1227739:HSW RS02060
gene id: 1227739:HSW_RS02060
uniprot id: W8EVG1
names: Similarity
messages: Belongs to the sigma-54 factor family.

1227739:HSW RS10295
gene id: 1227739:HSW_RS10295
uniprot id: W8F0B5
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1227739:HSW RS11855
gene id: 1227739:HSW_RS11855
uniprot id: W8EXD3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS07995
gene id: 1227739:HSW_RS07995
uniprot id: W8F5E4
names: Subcellular Location Annotation
messages: Nucleus

1227739:HSW RS03740
gene id: 1227739:HSW_RS03740
uniprot id: W8F2Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1227739:HSW RS02740
gene id: 1227739:HSW_RS02740
uniprot id: W8EZV7
names: Similarity
messages: Belongs to the UPF0102 family.

1227739:HSW RS23230
gene id: 1227739:HSW_RS23230
uniprot id: W8FDA2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

1227739:HSW RS21880
gene id: 1227739:HSW_RS21880
uniprot id: W8F727
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS21335
gene id: 1227739:HSW_RS21335
uniprot id: W8F417
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1227739:HSW RS20290
gene id: 1227739:HSW_RS20290
uniprot id: W8F290
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1227739:HSW RS19300
gene id: 1227739:HSW_RS19300
uniprot id: W8F2X4
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03620
gene id: 1227739:HSW_RS03620
uniprot id: W8F0E0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1227739:HSW RS00375
gene id: 1227739:HSW_RS00375
uniprot id: W8EUC5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS03340
gene id: 1227739:HSW_RS03340
uniprot id: W8EW66
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1227739:HSW RS21135
gene id: 1227739:HSW_RS21135
uniprot id: W8F2Q9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS19880
gene id: 1227739:HSW_RS19880
uniprot id: W8F3B9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1227739:HSW RS13555
gene id: 1227739:HSW_RS13555
uniprot id: W8F8S3
names: Similarity
messages: Belongs to the aspartokinase family.

1227739:HSW RS10435
gene id: 1227739:HSW_RS10435
uniprot id: W8F6W9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1227739:HSW RS03265
gene id: 1227739:HSW_RS03265
uniprot id: W8EW57
names: Similarity
messages: Belongs to the arginase family.

1227739:HSW RS07680
gene id: 1227739:HSW_RS07680
uniprot id: W8F537
names: Similarity
messages: Belongs to the CsgA/CsgB family.

1227739:HSW RS07720
gene id: 1227739:HSW_RS07720
uniprot id: W8F550
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

1227739:HSW RS01410
gene id: 1227739:HSW_RS01410
uniprot id: W8ESS9
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1227739:HSW RS19320
gene id: 1227739:HSW_RS19320
uniprot id: W8F2X9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1227739:HSW RS00325
gene id: 1227739:HSW_RS00325
uniprot id: W8F0G4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1227739:HSW RS11210
gene id: 1227739:HSW_RS11210
uniprot id: W8F7B5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1227739:HSW RS09570
gene id: 1227739:HSW_RS09570
uniprot id: W8EZT5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS11135
gene id: 1227739:HSW_RS11135
uniprot id: W8F7A0
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1227739:HSW RS03030
gene id: 1227739:HSW_RS03030
uniprot id: W8ES20
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1227739:HSW RS04070
gene id: 1227739:HSW_RS04070
uniprot id: W8EWH1
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1227739:HSW RS02830
gene id: 1227739:HSW_RS02830
uniprot id: W8ETL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1227739:HSW RS07375
gene id: 1227739:HSW_RS07375
uniprot id: W8F4W3
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1227739:HSW RS03860
gene id: 1227739:HSW_RS03860
uniprot id: W8ESG6
names: Similarity
messages: Belongs to the MreC family.

1227739:HSW RS19250
gene id: 1227739:HSW_RS19250
uniprot id: W8F2W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS03960
gene id: 1227739:HSW_RS03960
uniprot id: W8ESI4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1227739:HSW RS09035
gene id: 1227739:HSW_RS09035
uniprot id: W8EX54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1227739:HSW RS15490
gene id: 1227739:HSW_RS15490
uniprot id: W8F3D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS21255
gene id: 1227739:HSW_RS21255
uniprot id: W8F2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1227739:HSW RS06060
gene id: 1227739:HSW_RS06060
uniprot id: W8EXQ4
names: Similarity
messages: Belongs to the peptidase M13 family.

1227739:HSW RS05150
gene id: 1227739:HSW_RS05150
uniprot id: W8F198
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03655
gene id: 1227739:HSW_RS03655
uniprot id: W8ESC9
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS16250
gene id: 1227739:HSW_RS16250
uniprot id: W8F7R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

1227739:HSW RS03410
gene id: 1227739:HSW_RS03410
uniprot id: W8EW74
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS10330
gene id: 1227739:HSW_RS10330
uniprot id: W8EWJ3
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS01450
gene id: 1227739:HSW_RS01450
uniprot id: W8EZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS02355
gene id: 1227739:HSW_RS02355
uniprot id: W8F1S4
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1227739:HSW RS17850
gene id: 1227739:HSW_RS17850
uniprot id: W8F8R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1227739:HSW RS05965
gene id: 1227739:HSW_RS05965
uniprot id: W8EVH7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1227739:HSW RS10275
gene id: 1227739:HSW_RS10275
uniprot id: W8EXZ6
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS14465
gene id: 1227739:HSW_RS14465
uniprot id: W8F998
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

1227739:HSW RS19965
gene id: 1227739:HSW_RS19965
uniprot id: W8F3D6
names: Similarity
messages: Belongs to the histone deacetylase family.

1227739:HSW RS05490
gene id: 1227739:HSW_RS05490
uniprot id: W8F3V3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1227739:HSW RS16020
gene id: 1227739:HSW_RS16020
uniprot id: W8F7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

1227739:HSW RS21240
gene id: 1227739:HSW_RS21240
uniprot id: W8FAN4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1227739:HSW RS19420
gene id: 1227739:HSW_RS19420
uniprot id: W8F2Z7
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS07420
gene id: 1227739:HSW_RS07420
uniprot id: W8EUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS01645
gene id: 1227739:HSW_RS01645
uniprot id: W8F1D5
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1227739:HSW RS13255
gene id: 1227739:HSW_RS13255
uniprot id: W8EY76
names: Similarity
messages: Belongs to the DEAD box helicase family.

1227739:HSW RS19195
gene id: 1227739:HSW_RS19195
uniprot id: W8F5G1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1227739:HSW RS02935
gene id: 1227739:HSW_RS02935
uniprot id: W8F005
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS04075
gene id: 1227739:HSW_RS04075
uniprot id: W8EUE0
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1227739:HSW RS06600
gene id: 1227739:HSW_RS06600
uniprot id: W8EVU1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1227739:HSW RS15995
gene id: 1227739:HSW_RS15995
uniprot id: W8F3M5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1227739:HSW RS09275
gene id: 1227739:HSW_RS09275
uniprot id: W8F621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

1227739:HSW RS05055
gene id: 1227739:HSW_RS05055
uniprot id: W8EX33
names: Similarity
messages: Belongs to the pyruvate kinase family.

1227739:HSW RS12075
gene id: 1227739:HSW_RS12075
uniprot id: W8EXH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1227739:HSW RS19240
gene id: 1227739:HSW_RS19240
uniprot id: W8F9F8
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS21440
gene id: 1227739:HSW_RS21440
uniprot id: W8F439
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS02520
gene id: 1227739:HSW_RS02520
uniprot id: W8F1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1227739:HSW RS18030
gene id: 1227739:HSW_RS18030
uniprot id: W8F292
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1227739:HSW RS03120
gene id: 1227739:HSW_RS03120
uniprot id: W8EW38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS13335
gene id: 1227739:HSW_RS13335
uniprot id: W8EY93
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

1227739:HSW RS13690
gene id: 1227739:HSW_RS13690
uniprot id: W8EZS8
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

1227739:HSW RS05020
gene id: 1227739:HSW_RS05020
uniprot id: W8F3E9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS18230
gene id: 1227739:HSW_RS18230
uniprot id: W8F8W8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1227739:HSW RS03295
gene id: 1227739:HSW_RS03295
uniprot id: W8EU02
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1227739:HSW RS08900
gene id: 1227739:HSW_RS08900
uniprot id: W8F3G1
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS09980
gene id: 1227739:HSW_RS09980
uniprot id: W8F024
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS03155
gene id: 1227739:HSW_RS03155
uniprot id: W8ES43
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1227739:HSW RS18990
gene id: 1227739:HSW_RS18990
uniprot id: W8F1G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS13055
gene id: 1227739:HSW_RS13055
uniprot id: W8F8H7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS18390
gene id: 1227739:HSW_RS18390
uniprot id: W8F2F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0187 family.
messages: Membrane

1227739:HSW RS10880
gene id: 1227739:HSW_RS10880
uniprot id: W8EWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1227739:HSW RS12940
gene id: 1227739:HSW_RS12940
uniprot id: W8F5X1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1227739:HSW RS15915
gene id: 1227739:HSW_RS15915
uniprot id: W8F128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1227739:HSW RS08950
gene id: 1227739:HSW_RS08950
uniprot id: W8F5W0
names: Similarity
messages: Belongs to the UxaA family.

1227739:HSW RS16540
gene id: 1227739:HSW_RS16540
uniprot id: W8F027
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS01800
gene id: 1227739:HSW_RS01800
uniprot id: W8ET04
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1227739:HSW RS13960
gene id: 1227739:HSW_RS13960
uniprot id: W8EZY2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1227739:HSW RS14475
gene id: 1227739:HSW_RS14475
uniprot id: W8F075
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS02025
gene id: 1227739:HSW_RS02025
uniprot id: W8F1K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS09745
gene id: 1227739:HSW_RS09745
uniprot id: W8EZX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

1227739:HSW RS10010
gene id: 1227739:HSW_RS10010
uniprot id: W8F6J2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1227739:HSW RS22100
gene id: 1227739:HSW_RS22100
uniprot id: W8F4H7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1227739:HSW RS13115
gene id: 1227739:HSW_RS13115
uniprot id: W8F8I5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

1227739:HSW RS08365
gene id: 1227739:HSW_RS08365
uniprot id: W8EUY8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS09085
gene id: 1227739:HSW_RS09085
uniprot id: W8EVC1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS12495
gene id: 1227739:HSW_RS12495
uniprot id: W8F5L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1227739:HSW RS01845
gene id: 1227739:HSW_RS01845
uniprot id: W8ET12
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1227739:HSW RS12505
gene id: 1227739:HSW_RS12505
uniprot id: W8EZ48
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1227739:HSW RS18285
gene id: 1227739:HSW_RS18285
uniprot id: W8F4Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1227739:HSW RS20755
gene id: 1227739:HSW_RS20755
uniprot id: W8FD26
names: Similarity
messages: Belongs to the peptidase M4 family.

1227739:HSW RS21680
gene id: 1227739:HSW_RS21680
uniprot id: W8FDL4
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS16580
gene id: 1227739:HSW_RS16580
uniprot id: W8F1F7
names: Similarity
messages: Belongs to the ComB family.

1227739:HSW RS18125
gene id: 1227739:HSW_RS18125
uniprot id: W8F4W0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1227739:HSW RS12995
gene id: 1227739:HSW_RS12995
uniprot id: W8EZE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1227739:HSW RS12560
gene id: 1227739:HSW_RS12560
uniprot id: W8EXS5
names: Similarity
messages: Belongs to the DprA/Smf family.

1227739:HSW RS22930
gene id: 1227739:HSW_RS22930
uniprot id: W8EYT0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS14900
gene id: 1227739:HSW_RS14900
uniprot id: W8F0G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1227739:HSW RS01415
gene id: 1227739:HSW_RS01415
uniprot id: W8ER12
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS00590
gene id: 1227739:HSW_RS00590
uniprot id: W8ESB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1227739:HSW RS11220
gene id: 1227739:HSW_RS11220
uniprot id: W8EYH0
names: Similarity
messages: Belongs to the peptidase S1B family.

1227739:HSW RS11120
gene id: 1227739:HSW_RS11120
uniprot id: W8F0P8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1227739:HSW RS20985
gene id: 1227739:HSW_RS20985
uniprot id: W8F2M6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1227739:HSW RS20700
gene id: 1227739:HSW_RS20700
uniprot id: W8F2G9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1227739:HSW RS01575
gene id: 1227739:HSW_RS01575
uniprot id: W8EZ45
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1227739:HSW RS05470
gene id: 1227739:HSW_RS05470
uniprot id: W8F1J7
names: Similarity
messages: Belongs to the peptidase M42 family.

1227739:HSW RS10945
gene id: 1227739:HSW_RS10945
uniprot id: W8F759
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1227739:HSW RS10030
gene id: 1227739:HSW_RS10030
uniprot id: W8EVW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS17745
gene id: 1227739:HSW_RS17745
uniprot id: W8F244
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS11480
gene id: 1227739:HSW_RS11480
uniprot id: W8F0X1
names: Similarity
messages: Belongs to the type IB topoisomerase family.

1227739:HSW RS21720
gene id: 1227739:HSW_RS21720
uniprot id: W8F316
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS05960
gene id: 1227739:HSW_RS05960
uniprot id: W8EXN7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1227739:HSW RS15485
gene id: 1227739:HSW_RS15485
uniprot id: W8F7D4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1227739:HSW RS05015
gene id: 1227739:HSW_RS05015
uniprot id: W8ET31
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS08890
gene id: 1227739:HSW_RS08890
uniprot id: W8EV81
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1227739:HSW RS01550
gene id: 1227739:HSW_RS01550
uniprot id: W8EZ39
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1227739:HSW RS01560
gene id: 1227739:HSW_RS01560
uniprot id: W8ESW4
names: Similarity
messages: Belongs to the UPF0047 family.

1227739:HSW RS01945
gene id: 1227739:HSW_RS01945
uniprot id: W8ERC7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1227739:HSW RS20285
gene id: 1227739:HSW_RS20285
uniprot id: W8F3I0
names: Subunit
messages: Monomer.

1227739:HSW RS06795
gene id: 1227739:HSW_RS06795
uniprot id: W8EY33
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS01370
gene id: 1227739:HSW_RS01370
uniprot id: W8EZ00
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

1227739:HSW RS20885
gene id: 1227739:HSW_RS20885
uniprot id: W8F6H3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1227739:HSW RS18045
gene id: 1227739:HSW_RS18045
uniprot id: W8F8U5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1227739:HSW RS04665
gene id: 1227739:HSW_RS04665
uniprot id: W8EUP0
names: Similarity
messages: Belongs to the Skp family.

1227739:HSW RS21795
gene id: 1227739:HSW_RS21795
uniprot id: W8F329
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS10970
gene id: 1227739:HSW_RS10970
uniprot id: W8F764
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1227739:HSW RS13895
gene id: 1227739:HSW_RS13895
uniprot id: W8F8X8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1227739:HSW RS16895
gene id: 1227739:HSW_RS16895
uniprot id: W8F857
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1227739:HSW RS04440
gene id: 1227739:HSW_RS04440
uniprot id: W8ESS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1227739:HSW RS20210
gene id: 1227739:HSW_RS20210
uniprot id: W8F3G8
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1227739:HSW RS14710
gene id: 1227739:HSW_RS14710
uniprot id: W8F0C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1227739:HSW RS03935
gene id: 1227739:HSW_RS03935
uniprot id: W8EUB6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1227739:HSW RS19325
gene id: 1227739:HSW_RS19325
uniprot id: W8F1L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1227739:HSW RS08305
gene id: 1227739:HSW_RS08305
uniprot id: W8F358
names: Similarity
messages: Belongs to the hyi family.

1227739:HSW RS06165
gene id: 1227739:HSW_RS06165
uniprot id: W8ETS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1227739:HSW RS05115
gene id: 1227739:HSW_RS05115
uniprot id: W8ET51
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

1227739:HSW RS15375
gene id: 1227739:HSW_RS15375
uniprot id: W8F7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1227739:HSW RS14455
gene id: 1227739:HSW_RS14455
uniprot id: W8F070
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS01165
gene id: 1227739:HSW_RS01165
uniprot id: W8EYW7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1227739:HSW RS07060
gene id: 1227739:HSW_RS07060
uniprot id: W8EU85
names: Function
names: Similarity
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.

1227739:HSW RS15740
gene id: 1227739:HSW_RS15740
uniprot id: W8EZP0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

1227739:HSW RS07725
gene id: 1227739:HSW_RS07725
uniprot id: W8F2S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1227739:HSW RS10530
gene id: 1227739:HSW_RS10530
uniprot id: W8F6Y7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1227739:HSW RS06800
gene id: 1227739:HSW_RS06800
uniprot id: W8EVX9
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1227739:HSW RS08915
gene id: 1227739:HSW_RS08915
uniprot id: W8EV85
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

1227739:HSW RS17055
gene id: 1227739:HSW_RS17055
uniprot id: W8F1P4
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1227739:HSW RS16055
gene id: 1227739:HSW_RS16055
uniprot id: W8F7N2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS08810
gene id: 1227739:HSW_RS08810
uniprot id: W8EZB5
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

1227739:HSW RS18755
gene id: 1227739:HSW_RS18755
uniprot id: W8F962
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1227739:HSW RS19955
gene id: 1227739:HSW_RS19955
uniprot id: W8F9Z8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

1227739:HSW RS00345
gene id: 1227739:HSW_RS00345
uniprot id: W8F0H1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1227739:HSW RS15030
gene id: 1227739:HSW_RS15030
uniprot id: W8F362
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS15730
gene id: 1227739:HSW_RS15730
uniprot id: W8F3H0
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS06820
gene id: 1227739:HSW_RS06820
uniprot id: W8F267
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.
messages: Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
messages: Homotrimer.

1227739:HSW RS01890
gene id: 1227739:HSW_RS01890
uniprot id: W8EVC5
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS14180
gene id: 1227739:HSW_RS14180
uniprot id: W8F6I9
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS15775
gene id: 1227739:HSW_RS15775
uniprot id: W8F3H8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1227739:HSW RS17010
gene id: 1227739:HSW_RS17010
uniprot id: W8F0A9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1227739:HSW RS03205
gene id: 1227739:HSW_RS03205
uniprot id: W8F2E8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1227739:HSW RS04920
gene id: 1227739:HSW_RS04920
uniprot id: W8F145
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1227739:HSW RS10240
gene id: 1227739:HSW_RS10240
uniprot id: W8F4B8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS09890
gene id: 1227739:HSW_RS09890
uniprot id: W8EXM9
names: Similarity
messages: Belongs to the Lgt family.

1227739:HSW RS01765
gene id: 1227739:HSW_RS01765
uniprot id: W8F1F8
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS21180
gene id: 1227739:HSW_RS21180
uniprot id: W8F2R9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1227739:HSW RS20980
gene id: 1227739:HSW_RS20980
uniprot id: W8F3U9
names: Similarity
messages: Belongs to the MoaD family.

1227739:HSW RS15885
gene id: 1227739:HSW_RS15885
uniprot id: W8FA70
names: Similarity
messages: Belongs to the LOG family.

1227739:HSW RS08025
gene id: 1227739:HSW_RS08025
uniprot id: W8F318
names: Similarity
messages: Belongs to the universal stress protein A family.

1227739:HSW RS11230
gene id: 1227739:HSW_RS11230
uniprot id: W8F7B9
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS18225
gene id: 1227739:HSW_RS18225
uniprot id: W8FBL7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS17050
gene id: 1227739:HSW_RS17050
uniprot id: W8F491
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1227739:HSW RS11655
gene id: 1227739:HSW_RS11655
uniprot id: W8F7J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1227739:HSW RS11515
gene id: 1227739:HSW_RS11515
uniprot id: W8EX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1227739:HSW RS15855
gene id: 1227739:HSW_RS15855
uniprot id: W8EZR1
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

1227739:HSW RS20870
gene id: 1227739:HSW_RS20870
uniprot id: W8F2K3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1227739:HSW RS16350
gene id: 1227739:HSW_RS16350
uniprot id: W8F7T7
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1227739:HSW RS12015
gene id: 1227739:HSW_RS12015
uniprot id: W8F193
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1227739:HSW RS09660
gene id: 1227739:HSW_RS09660
uniprot id: W8EVP1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1227739:HSW RS05155
gene id: 1227739:HSW_RS05155
uniprot id: W8EX52
names: Similarity
messages: Belongs to the catalase family.

1227739:HSW RS15610
gene id: 1227739:HSW_RS15610
uniprot id: W8F3F0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1227739:HSW RS01930
gene id: 1227739:HSW_RS01930
uniprot id: W8EZA9
names: Similarity
messages: Belongs to the pirin family.

1227739:HSW RS02650
gene id: 1227739:HSW_RS02650
uniprot id: W8EZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS18325
gene id: 1227739:HSW_RS18325
uniprot id: W8FBN4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1227739:HSW RS04770
gene id: 1227739:HSW_RS04770
uniprot id: W8F115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1227739:HSW RS07620
gene id: 1227739:HSW_RS07620
uniprot id: W8EWB9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1227739:HSW RS19890
gene id: 1227739:HSW_RS19890
uniprot id: W8FCN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1227739:HSW RS16775
gene id: 1227739:HSW_RS16775
uniprot id: W8FAP7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1227739:HSW RS21310
gene id: 1227739:HSW_RS21310
uniprot id: W8F413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1227739:HSW RS03490
gene id: 1227739:HSW_RS03490
uniprot id: W8F2K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1227739:HSW RS04420
gene id: 1227739:HSW_RS04420
uniprot id: W8EUJ5
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS12535
gene id: 1227739:HSW_RS12535
uniprot id: W8EZ52
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1227739:HSW RS04050
gene id: 1227739:HSW_RS04050
uniprot id: W8EUD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1227739:HSW RS06715
gene id: 1227739:HSW_RS06715
uniprot id: W8F245
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1227739:HSW RS09210
gene id: 1227739:HSW_RS09210
uniprot id: W8F606
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS18720
gene id: 1227739:HSW_RS18720
uniprot id: W8F1B1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1227739:HSW RS03195
gene id: 1227739:HSW_RS03195
uniprot id: W8ETY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1227739:HSW RS03650
gene id: 1227739:HSW_RS03650
uniprot id: W8EU66
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS05880
gene id: 1227739:HSW_RS05880
uniprot id: W8EVG2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1227739:HSW RS15480
gene id: 1227739:HSW_RS15480
uniprot id: W8F9Z2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1227739:HSW RS16185
gene id: 1227739:HSW_RS16185
uniprot id: W8FAC6
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

1227739:HSW RS22490
gene id: 1227739:HSW_RS22490
uniprot id: W8ESM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1227739:HSW RS18825
gene id: 1227739:HSW_RS18825
uniprot id: W8FBY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1227739:HSW RS04460
gene id: 1227739:HSW_RS04460
uniprot id: W8EUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1227739:HSW RS21930
gene id: 1227739:HSW_RS21930
uniprot id: W8F735
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS09300
gene id: 1227739:HSW_RS09300
uniprot id: W8F3P7
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS18790
gene id: 1227739:HSW_RS18790
uniprot id: W8F2N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1227739:HSW RS19160
gene id: 1227739:HSW_RS19160
uniprot id: W8F2U9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

1227739:HSW RS15815
gene id: 1227739:HSW_RS15815
uniprot id: W8FA57
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1227739:HSW RS09060
gene id: 1227739:HSW_RS09060
uniprot id: W8F5X9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1227739:HSW RS06555
gene id: 1227739:HSW_RS06555
uniprot id: W8ETZ4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS05000
gene id: 1227739:HSW_RS05000
uniprot id: W8F164
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1227739:HSW RS19705
gene id: 1227739:HSW_RS19705
uniprot id: W8F1U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1227739:HSW RS03175
gene id: 1227739:HSW_RS03175
uniprot id: W8ES46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

1227739:HSW RS19855
gene id: 1227739:HSW_RS19855
uniprot id: W8F3A0
names: Similarity
messages: Belongs to the AIR synthase family.

1227739:HSW RS09105
gene id: 1227739:HSW_RS09105
uniprot id: W8EX64
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1227739:HSW RS06675
gene id: 1227739:HSW_RS06675
uniprot id: W8EY10
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

1227739:HSW RS15625
gene id: 1227739:HSW_RS15625
uniprot id: W8F7F4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS00945
gene id: 1227739:HSW_RS00945
uniprot id: W8ESI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS10935
gene id: 1227739:HSW_RS10935
uniprot id: W8EYB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1227739:HSW RS03925
gene id: 1227739:HSW_RS03925
uniprot id: W8F0J2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1227739:HSW RS11750
gene id: 1227739:HSW_RS11750
uniprot id: W8F543
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS11945
gene id: 1227739:HSW_RS11945
uniprot id: W8EYU1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1227739:HSW RS10080
gene id: 1227739:HSW_RS10080
uniprot id: W8EXS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1227739:HSW RS19935
gene id: 1227739:HSW_RS19935
uniprot id: W8F9Z3
names: Subcellular Location Annotation
messages: Cell inner membrane

1227739:HSW RS09780
gene id: 1227739:HSW_RS09780
uniprot id: W8EVR5
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1227739:HSW RS07610
gene id: 1227739:HSW_RS07610
uniprot id: W8F2P6
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1227739:HSW RS17985
gene id: 1227739:HSW_RS17985
uniprot id: W8F0X8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1227739:HSW RS17130
gene id: 1227739:HSW_RS17130
uniprot id: W8FAY0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1227739:HSW RS04975
gene id: 1227739:HSW_RS04975
uniprot id: W8F158
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1227739:HSW RS07230
gene id: 1227739:HSW_RS07230
uniprot id: W8EW51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1227739:HSW RS05600
gene id: 1227739:HSW_RS05600
uniprot id: W8F1L6
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1227739:HSW RS21805
gene id: 1227739:HSW_RS21805
uniprot id: W8FAZ9
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS14725
gene id: 1227739:HSW_RS14725
uniprot id: W8F2W3
names: Similarity
messages: Belongs to the peptidase M1 family.

1227739:HSW RS20485
gene id: 1227739:HSW_RS20485
uniprot id: W8FA84
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1227739:HSW RS11200
gene id: 1227739:HSW_RS11200
uniprot id: W8EYG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell.

1227739:HSW RS17390
gene id: 1227739:HSW_RS17390
uniprot id: W8F8G2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1227739:HSW RS00910
gene id: 1227739:HSW_RS00910
uniprot id: W8EQR7
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS02320
gene id: 1227739:HSW_RS02320
uniprot id: W8ET97
names: Similarity
messages: Belongs to the universal stress protein A family.

1227739:HSW RS14095
gene id: 1227739:HSW_RS14095
uniprot id: W8F918
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1227739:HSW RS14930
gene id: 1227739:HSW_RS14930
uniprot id: W8F310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS07175
gene id: 1227739:HSW_RS07175
uniprot id: W8EYB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1227739:HSW RS06345
gene id: 1227739:HSW_RS06345
uniprot id: W8ETV1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

1227739:HSW RS00845
gene id: 1227739:HSW_RS00845
uniprot id: W8EQQ5
names: Subcellular Location Annotation
messages: Cell inner membrane

1227739:HSW RS14800
gene id: 1227739:HSW_RS14800
uniprot id: W8F0E7
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS20645
gene id: 1227739:HSW_RS20645
uniprot id: W8FAB3
names: Similarity
messages: Belongs to the BshC family.

1227739:HSW RS21045
gene id: 1227739:HSW_RS21045
uniprot id: W8FAJ7
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS20675
gene id: 1227739:HSW_RS20675
uniprot id: W8F3Q0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1227739:HSW RS03785
gene id: 1227739:HSW_RS03785
uniprot id: W8ESF0
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

1227739:HSW RS09705
gene id: 1227739:HSW_RS09705
uniprot id: W8EXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS04175
gene id: 1227739:HSW_RS04175
uniprot id: W8EWI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1227739:HSW RS06845
gene id: 1227739:HSW_RS06845
uniprot id: W8F272
names: Similarity
messages: Belongs to the peptidase S49 family.

1227739:HSW RS07750
gene id: 1227739:HSW_RS07750
uniprot id: W8F2T0
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS14635
gene id: 1227739:HSW_RS14635
uniprot id: W8F2U4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1227739:HSW RS14305
gene id: 1227739:HSW_RS14305
uniprot id: W8F2L7
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS11920
gene id: 1227739:HSW_RS11920
uniprot id: W8EYT7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1227739:HSW RS18965
gene id: 1227739:HSW_RS18965
uniprot id: W8F1F6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1227739:HSW RS07775
gene id: 1227739:HSW_RS07775
uniprot id: W8F2T4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1227739:HSW RS05430
gene id: 1227739:HSW_RS05430
uniprot id: W8EV86
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1227739:HSW RS06650
gene id: 1227739:HSW_RS06650
uniprot id: W8EVV1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1227739:HSW RS16285
gene id: 1227739:HSW_RS16285
uniprot id: W8F1A1
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1227739:HSW RS10125
gene id: 1227739:HSW_RS10125
uniprot id: W8F052
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1227739:HSW RS05895
gene id: 1227739:HSW_RS05895
uniprot id: W8F1Q9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1227739:HSW RS03230
gene id: 1227739:HSW_RS03230
uniprot id: W8F2F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1227739:HSW RS23035
gene id: 1227739:HSW_RS23035
uniprot id: W8F8F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1227739:HSW RS15575
gene id: 1227739:HSW_RS15575
uniprot id: W8FA09
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1227739:HSW RS18815
gene id: 1227739:HSW_RS18815
uniprot id: W8F2P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1227739:HSW RS00960
gene id: 1227739:HSW_RS00960
uniprot id: W8EUS3
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1227739:HSW RS05005
gene id: 1227739:HSW_RS05005
uniprot id: W8EX22
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1227739:HSW RS17355
gene id: 1227739:HSW_RS17355
uniprot id: W8F0I6
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS16260
gene id: 1227739:HSW_RS16260
uniprot id: W8F197
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1227739:HSW RS11850
gene id: 1227739:HSW_RS11850
uniprot id: W8EYS6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1227739:HSW RS03765
gene id: 1227739:HSW_RS03765
uniprot id: W8F2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

1227739:HSW RS12090
gene id: 1227739:HSW_RS12090
uniprot id: W8F1A9
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1227739:HSW RS18870
gene id: 1227739:HSW_RS18870
uniprot id: W8F1E1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1227739:HSW RS04895
gene id: 1227739:HSW_RS04895
uniprot id: W8F3C2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1227739:HSW RS02865
gene id: 1227739:HSW_RS02865
uniprot id: W8EZY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1227739:HSW RS14925
gene id: 1227739:HSW_RS14925
uniprot id: W8F708
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS17730
gene id: 1227739:HSW_RS17730
uniprot id: W8FBD1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1227739:HSW RS15620
gene id: 1227739:HSW_RS15620
uniprot id: W8FA18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1227739:HSW RS21975
gene id: 1227739:HSW_RS21975
uniprot id: W8FB35
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1227739:HSW RS11315
gene id: 1227739:HSW_RS11315
uniprot id: W8F0T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1227739:HSW RS10515
gene id: 1227739:HSW_RS10515
uniprot id: W8F4H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1227739:HSW RS19585
gene id: 1227739:HSW_RS19585
uniprot id: W8FCD8
names: Similarity
messages: Belongs to the UPF0234 family.

1227739:HSW RS18840
gene id: 1227739:HSW_RS18840
uniprot id: W8F2P5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1227739:HSW RS03900
gene id: 1227739:HSW_RS03900
uniprot id: W8F0I9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1227739:HSW RS02835
gene id: 1227739:HSW_RS02835
uniprot id: W8ERU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1227739:HSW RS18540
gene id: 1227739:HSW_RS18540
uniprot id: W8F922
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1227739:HSW RS21870
gene id: 1227739:HSW_RS21870
uniprot id: W8FDQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS22270
gene id: 1227739:HSW_RS22270
uniprot id: W8EQ76
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1227739:HSW RS09420
gene id: 1227739:HSW_RS09420
uniprot id: W8EVJ0
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.

1227739:HSW RS21910
gene id: 1227739:HSW_RS21910
uniprot id: W8F4D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1227739:HSW RS20490
gene id: 1227739:HSW_RS20490
uniprot id: W8F696
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS21840
gene id: 1227739:HSW_RS21840
uniprot id: W8F4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1227739:HSW RS04370
gene id: 1227739:HSW_RS04370
uniprot id: W8EUI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1227739:HSW RS01735
gene id: 1227739:HSW_RS01735
uniprot id: W8ESZ2
names: Similarity
messages: Belongs to the peptidase M13 family.

1227739:HSW RS12580
gene id: 1227739:HSW_RS12580
uniprot id: W8EZ75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1227739:HSW RS18680
gene id: 1227739:HSW_RS18680
uniprot id: W8F950
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1227739:HSW RS11160
gene id: 1227739:HSW_RS11160
uniprot id: W8F7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1227739:HSW RS07050
gene id: 1227739:HSW_RS07050
uniprot id: W8EW26
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1227739:HSW RS08925
gene id: 1227739:HSW_RS08925
uniprot id: W8F3G6
names: Similarity
messages: Belongs to the SusD family.

1227739:HSW RS01425
gene id: 1227739:HSW_RS01425
uniprot id: W8EZ14
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1227739:HSW RS21155
gene id: 1227739:HSW_RS21155
uniprot id: W8F3Y2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1227739:HSW RS20145
gene id: 1227739:HSW_RS20145
uniprot id: W8F3F8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1227739:HSW RS04710
gene id: 1227739:HSW_RS04710
uniprot id: W8EUP6
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1227739:HSW RS05065
gene id: 1227739:HSW_RS05065
uniprot id: W8ET40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1227739:HSW RS01995
gene id: 1227739:HSW_RS01995
uniprot id: W8ERD7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 3-HAO family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

1227739:HSW RS15920
gene id: 1227739:HSW_RS15920
uniprot id: W8EZS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1227739:HSW RS03955
gene id: 1227739:HSW_RS03955
uniprot id: W8EWF6
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS03095
gene id: 1227739:HSW_RS03095
uniprot id: W8EW34
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS16385
gene id: 1227739:HSW_RS16385
uniprot id: W8F1B9
names: Similarity
messages: Belongs to the SCO1/2 family.

1227739:HSW RS19145
gene id: 1227739:HSW_RS19145
uniprot id: W8FC44
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

1227739:HSW RS13420
gene id: 1227739:HSW_RS13420
uniprot id: W8EZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

1227739:HSW RS21055
gene id: 1227739:HSW_RS21055
uniprot id: W8F3W3
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1227739:HSW RS19465
gene id: 1227739:HSW_RS19465
uniprot id: W8F307
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1227739:HSW RS02135
gene id: 1227739:HSW_RS02135
uniprot id: W8EVH6
names: Subcellular Location Annotation
messages: Membrane

1227739:HSW RS05675
gene id: 1227739:HSW_RS05675
uniprot id: W8F1M5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1227739:HSW RS15140
gene id: 1227739:HSW_RS15140
uniprot id: W8F9U1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.