1224163:B841 RS02975
gene id: 1224163:B841_RS02975
uniprot id: S5SSG7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224163:B841 RS10880
gene id: 1224163:B841_RS10880
uniprot id: S5SWL8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1224163:B841 RS00180
gene id: 1224163:B841_RS00180
uniprot id: S5TF36
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

1224163:B841 RS10870
gene id: 1224163:B841_RS10870
uniprot id: S5SX03
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1224163:B841 RS06485
gene id: 1224163:B841_RS06485
uniprot id: S5T2C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1224163:B841 RS06390
gene id: 1224163:B841_RS06390
uniprot id: S5TIK6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1224163:B841 RS02125
gene id: 1224163:B841_RS02125
uniprot id: S5TGV1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1224163:B841 RS01680
gene id: 1224163:B841_RS01680
uniprot id: S5TGK8
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

1224163:B841 RS11630
gene id: 1224163:B841_RS11630
uniprot id: S5TM32
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03955
gene id: 1224163:B841_RS03955
uniprot id: S5THS8
names: Similarity
messages: Belongs to the HsdR family.

1224163:B841 RS03245
gene id: 1224163:B841_RS03245
uniprot id: S5SSV4
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

1224163:B841 RS05755
gene id: 1224163:B841_RS05755
uniprot id: S5T203
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1224163:B841 RS00880
gene id: 1224163:B841_RS00880
uniprot id: S5TG56
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-68 and Arg-71) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1224163:B841 RS01420
gene id: 1224163:B841_RS01420
uniprot id: S5TFP5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1224163:B841 RS07955
gene id: 1224163:B841_RS07955
uniprot id: S5TJL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1224163:B841 RS03145
gene id: 1224163:B841_RS03145
uniprot id: S5THD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1224163:B841 RS11560
gene id: 1224163:B841_RS11560
uniprot id: S5SWX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS00820
gene id: 1224163:B841_RS00820
uniprot id: S5TFE9
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1224163:B841 RS08625
gene id: 1224163:B841_RS08625
uniprot id: S5T3F3
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03010
gene id: 1224163:B841_RS03010
uniprot id: S5TGQ6
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS00320
gene id: 1224163:B841_RS00320
uniprot id: S5SR40
names: Similarity
messages: Belongs to the CmpA/NrtA family.

1224163:B841 RS04995
gene id: 1224163:B841_RS04995
uniprot id: S5TID0
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS09700
gene id: 1224163:B841_RS09700
uniprot id: S5SVZ0
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1224163:B841 RS06520
gene id: 1224163:B841_RS06520
uniprot id: S5SUN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS05380
gene id: 1224163:B841_RS05380
uniprot id: S5STS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1224163:B841 RS07755
gene id: 1224163:B841_RS07755
uniprot id: S5TJI3
names: Similarity
messages: Belongs to the serine/threonine dehydratase family. DsdA subfamily.

1224163:B841 RS10890
gene id: 1224163:B841_RS10890
uniprot id: S5TL71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1224163:B841 RS03280
gene id: 1224163:B841_RS03280
uniprot id: S5SSK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS07480
gene id: 1224163:B841_RS07480
uniprot id: S5SV92
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS10920
gene id: 1224163:B841_RS10920
uniprot id: S5T4S6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1224163:B841 RS06210
gene id: 1224163:B841_RS06210
uniprot id: S5TIH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1224163:B841 RS11395
gene id: 1224163:B841_RS11395
uniprot id: S5TLF1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS08100
gene id: 1224163:B841_RS08100
uniprot id: S5T370
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1224163:B841 RS05490
gene id: 1224163:B841_RS05490
uniprot id: S5SU49
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

1224163:B841 RS11555
gene id: 1224163:B841_RS11555
uniprot id: S5TM17
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11735
gene id: 1224163:B841_RS11735
uniprot id: S5SX16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1224163:B841 RS04105
gene id: 1224163:B841_RS04105
uniprot id: S5STA8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1224163:B841 RS05530
gene id: 1224163:B841_RS05530
uniprot id: S5T1W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224163:B841 RS07505
gene id: 1224163:B841_RS07505
uniprot id: S5SV97
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

1224163:B841 RS11365
gene id: 1224163:B841_RS11365
uniprot id: S5T4Z9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1224163:B841 RS10610
gene id: 1224163:B841_RS10610
uniprot id: S5SWI0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224163:B841 RS08235
gene id: 1224163:B841_RS08235
uniprot id: S5SVM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1224163:B841 RS05880
gene id: 1224163:B841_RS05880
uniprot id: S5T222
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224163:B841 RS11375
gene id: 1224163:B841_RS11375
uniprot id: S5SX69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224163:B841 RS01415
gene id: 1224163:B841_RS01415
uniprot id: S5SZR1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1224163:B841 RS11110
gene id: 1224163:B841_RS11110
uniprot id: S5T4V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1224163:B841 RS01815
gene id: 1224163:B841_RS01815
uniprot id: S5SRT9
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1224163:B841 RS08920
gene id: 1224163:B841_RS08920
uniprot id: S5T3L3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS06435
gene id: 1224163:B841_RS06435
uniprot id: S5T2B9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1224163:B841 RS00965
gene id: 1224163:B841_RS00965
uniprot id: S5SZH3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224163:B841 RS05710
gene id: 1224163:B841_RS05710
uniprot id: S5TI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS11580
gene id: 1224163:B841_RS11580
uniprot id: S5TM22
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS05090
gene id: 1224163:B841_RS05090
uniprot id: S5STY1
names: Caution
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS05945
gene id: 1224163:B841_RS05945
uniprot id: S5TIT0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1224163:B841 RS04620
gene id: 1224163:B841_RS04620
uniprot id: S5TI46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

1224163:B841 RS04530
gene id: 1224163:B841_RS04530
uniprot id: S5STI8
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS10070
gene id: 1224163:B841_RS10070
uniprot id: S5TL94
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1224163:B841 RS11800
gene id: 1224163:B841_RS11800
uniprot id: S5SXD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1224163:B841 RS07240
gene id: 1224163:B841_RS07240
uniprot id: S5SUN1
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1224163:B841 RS05140
gene id: 1224163:B841_RS05140
uniprot id: S5T1R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1224163:B841 RS07430
gene id: 1224163:B841_RS07430
uniprot id: S5SV80
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS07550
gene id: 1224163:B841_RS07550
uniprot id: S5TJD8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS08305
gene id: 1224163:B841_RS08305
uniprot id: S5TJR3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1224163:B841 RS02990
gene id: 1224163:B841_RS02990
uniprot id: S5SSR4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1224163:B841 RS05820
gene id: 1224163:B841_RS05820
uniprot id: S5TIR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1224163:B841 RS03830
gene id: 1224163:B841_RS03830
uniprot id: S5TH34
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1224163:B841 RS02585
gene id: 1224163:B841_RS02585
uniprot id: S5TGH8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1224163:B841 RS12430
gene id: 1224163:B841_RS12430
uniprot id: S5TMK7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS04080
gene id: 1224163:B841_RS04080
uniprot id: S5ST98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1224163:B841 RS09380
gene id: 1224163:B841_RS09380
uniprot id: S5SW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1224163:B841 RS08415
gene id: 1224163:B841_RS08415
uniprot id: S5TK71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1224163:B841 RS06075
gene id: 1224163:B841_RS06075
uniprot id: S5SU35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1224163:B841 RS10255
gene id: 1224163:B841_RS10255
uniprot id: S5T4H3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1224163:B841 RS05640
gene id: 1224163:B841_RS05640
uniprot id: S5TI82
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02965
gene id: 1224163:B841_RS02965
uniprot id: S5SSR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1224163:B841 RS06465
gene id: 1224163:B841_RS06465
uniprot id: S5TIM3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1224163:B841 RS09080
gene id: 1224163:B841_RS09080
uniprot id: S5SW10
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1224163:B841 RS01490
gene id: 1224163:B841_RS01490
uniprot id: S5SZS8
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11815
gene id: 1224163:B841_RS11815
uniprot id: S5T584
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS08520
gene id: 1224163:B841_RS08520
uniprot id: S5SVC1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1224163:B841 RS02185
gene id: 1224163:B841_RS02185
uniprot id: S5T062
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS03715
gene id: 1224163:B841_RS03715
uniprot id: S5TH19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1224163:B841 RS09770
gene id: 1224163:B841_RS09770
uniprot id: S5SWE8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1224163:B841 RS12865
gene id: 1224163:B841_RS12865
uniprot id: S5SY06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1224163:B841 RS09240
gene id: 1224163:B841_RS09240
uniprot id: S5T3S9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1224163:B841 RS11180
gene id: 1224163:B841_RS11180
uniprot id: S5SWQ5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1224163:B841 RS00830
gene id: 1224163:B841_RS00830
uniprot id: S5TG48
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1224163:B841 RS07675
gene id: 1224163:B841_RS07675
uniprot id: S5SUZ0
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1224163:B841 RS09970
gene id: 1224163:B841_RS09970
uniprot id: S5SWJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1224163:B841 RS08980
gene id: 1224163:B841_RS08980
uniprot id: S5SVZ6
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

1224163:B841 RS10515
gene id: 1224163:B841_RS10515
uniprot id: S5TL09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1224163:B841 RS00785
gene id: 1224163:B841_RS00785
uniprot id: S5SRB3
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1224163:B841 RS05325
gene id: 1224163:B841_RS05325
uniprot id: S5SU18
names: Similarity
messages: Belongs to the LOG family.

1224163:B841 RS01775
gene id: 1224163:B841_RS01775
uniprot id: S5TFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS11915
gene id: 1224163:B841_RS11915
uniprot id: S5T5A6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1224163:B841 RS01785
gene id: 1224163:B841_RS01785
uniprot id: S5TGN1
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1224163:B841 RS06015
gene id: 1224163:B841_RS06015
uniprot id: S5SUE9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1224163:B841 RS02555
gene id: 1224163:B841_RS02555
uniprot id: S5T0E3
names: Similarity
messages: Belongs to the asp23 family.

1224163:B841 RS07350
gene id: 1224163:B841_RS07350
uniprot id: S5TJ84
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS08855
gene id: 1224163:B841_RS08855
uniprot id: S5SVX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1224163:B841 RS01125
gene id: 1224163:B841_RS01125
uniprot id: S5SRR2
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1224163:B841 RS07510
gene id: 1224163:B841_RS07510
uniprot id: S5TJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1224163:B841 RS06455
gene id: 1224163:B841_RS06455
uniprot id: S5SU89
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS01610
gene id: 1224163:B841_RS01610
uniprot id: S5SRP9
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS06215
gene id: 1224163:B841_RS06215
uniprot id: S5SUH8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1224163:B841 RS05630
gene id: 1224163:B841_RS05630
uniprot id: S5STW2
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1224163:B841 RS07365
gene id: 1224163:B841_RS07365
uniprot id: S5SUQ6
names: Similarity
messages: Belongs to the peptidase A24 family.

1224163:B841 RS06500
gene id: 1224163:B841_RS06500
uniprot id: S5TJ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1224163:B841 RS09870
gene id: 1224163:B841_RS09870
uniprot id: S5SWH4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1224163:B841 RS07390
gene id: 1224163:B841_RS07390
uniprot id: S5SUR3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1224163:B841 RS07730
gene id: 1224163:B841_RS07730
uniprot id: S5TJH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS02385
gene id: 1224163:B841_RS02385
uniprot id: S5TGB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224163:B841 RS11065
gene id: 1224163:B841_RS11065
uniprot id: S5TL91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1224163:B841 RS12435
gene id: 1224163:B841_RS12435
uniprot id: S5SXE4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS05050
gene id: 1224163:B841_RS05050
uniprot id: S5STK1
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS06555
gene id: 1224163:B841_RS06555
uniprot id: S5SUN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS11515
gene id: 1224163:B841_RS11515
uniprot id: S5T523
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1224163:B841 RS08870
gene id: 1224163:B841_RS08870
uniprot id: S5T3K3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1224163:B841 RS04095
gene id: 1224163:B841_RS04095
uniprot id: S5T152
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1224163:B841 RS01755
gene id: 1224163:B841_RS01755
uniprot id: S5SS19
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224163:B841 RS11450
gene id: 1224163:B841_RS11450
uniprot id: S5SX78
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1224163:B841 RS09235
gene id: 1224163:B841_RS09235
uniprot id: S5SVQ1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1224163:B841 RS03210
gene id: 1224163:B841_RS03210
uniprot id: S5T0P4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1224163:B841 RS04415
gene id: 1224163:B841_RS04415
uniprot id: S5STG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1224163:B841 RS03390
gene id: 1224163:B841_RS03390
uniprot id: S5SSX9
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224163:B841 RS02625
gene id: 1224163:B841_RS02625
uniprot id: S5SSC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1224163:B841 RS11530
gene id: 1224163:B841_RS11530
uniprot id: S5TM09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1224163:B841 RS08325
gene id: 1224163:B841_RS08325
uniprot id: S5T3A0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1224163:B841 RS09990
gene id: 1224163:B841_RS09990
uniprot id: S5TKP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS10330
gene id: 1224163:B841_RS10330
uniprot id: S5TKY1
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1224163:B841 RS11460
gene id: 1224163:B841_RS11460
uniprot id: S5SWV7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1224163:B841 RS08835
gene id: 1224163:B841_RS08835
uniprot id: S5TKJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1224163:B841 RS04235
gene id: 1224163:B841_RS04235
uniprot id: S5STD0
names: Similarity
messages: Belongs to the peptidase C56 family.

1224163:B841 RS04420
gene id: 1224163:B841_RS04420
uniprot id: S5TI09
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS01990
gene id: 1224163:B841_RS01990
uniprot id: S5SRX5
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS09475
gene id: 1224163:B841_RS09475
uniprot id: S5TKC2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1224163:B841 RS07040
gene id: 1224163:B841_RS07040
uniprot id: S5SUJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1224163:B841 RS10115
gene id: 1224163:B841_RS10115
uniprot id: S5SWN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1224163:B841 RS00660
gene id: 1224163:B841_RS00660
uniprot id: S5SR92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224163:B841 RS03070
gene id: 1224163:B841_RS03070
uniprot id: S5THB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS10525
gene id: 1224163:B841_RS10525
uniprot id: S5TLJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1224163:B841 RS07195
gene id: 1224163:B841_RS07195
uniprot id: S5T2P8
names: Caution
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS07935
gene id: 1224163:B841_RS07935
uniprot id: S5SVI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS12545
gene id: 1224163:B841_RS12545
uniprot id: S5TMN1
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS07660
gene id: 1224163:B841_RS07660
uniprot id: S5TJG9
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1224163:B841 RS09785
gene id: 1224163:B841_RS09785
uniprot id: S5T430
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1224163:B841 RS09775
gene id: 1224163:B841_RS09775
uniprot id: S5TL24
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

1224163:B841 RS08160
gene id: 1224163:B841_RS08160
uniprot id: S5SVL6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1224163:B841 RS01280
gene id: 1224163:B841_RS01280
uniprot id: S5TFM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1224163:B841 RS06495
gene id: 1224163:B841_RS06495
uniprot id: S5SUM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1224163:B841 RS12665
gene id: 1224163:B841_RS12665
uniprot id: S5SXU7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1224163:B841 RS09030
gene id: 1224163:B841_RS09030
uniprot id: S5SW03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
messages: Membrane

1224163:B841 RS08960
gene id: 1224163:B841_RS08960
uniprot id: S5TKL8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1224163:B841 RS08580
gene id: 1224163:B841_RS08580
uniprot id: S5TJV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1224163:B841 RS03065
gene id: 1224163:B841_RS03065
uniprot id: S5SSS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS11125
gene id: 1224163:B841_RS11125
uniprot id: S5TLT7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1224163:B841 RS10435
gene id: 1224163:B841_RS10435
uniprot id: S5T4K7
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1224163:B841 RS11335
gene id: 1224163:B841_RS11335
uniprot id: S5SWT0
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1224163:B841 RS08090
gene id: 1224163:B841_RS08090
uniprot id: S5TK19
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS13275
gene id: 1224163:B841_RS13275
uniprot id: S5SSK4
names: Similarity
messages: Belongs to the asp23 family.

1224163:B841 RS05770
gene id: 1224163:B841_RS05770
uniprot id: S5TIQ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1224163:B841 RS02515
gene id: 1224163:B841_RS02515
uniprot id: S5SSJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1224163:B841 RS04960
gene id: 1224163:B841_RS04960
uniprot id: S5THT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS02970
gene id: 1224163:B841_RS02970
uniprot id: S5THA3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224163:B841 RS00090
gene id: 1224163:B841_RS00090
uniprot id: S5SR10
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1224163:B841 RS05830
gene id: 1224163:B841_RS05830
uniprot id: S5T214
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1224163:B841 RS02670
gene id: 1224163:B841_RS02670
uniprot id: S5TH64
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1224163:B841 RS11980
gene id: 1224163:B841_RS11980
uniprot id: S5TMB2
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

1224163:B841 RS07250
gene id: 1224163:B841_RS07250
uniprot id: S5TJ62
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS07105
gene id: 1224163:B841_RS07105
uniprot id: S5SUZ8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1224163:B841 RS06765
gene id: 1224163:B841_RS06765
uniprot id: S5SUE3
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1224163:B841 RS09555
gene id: 1224163:B841_RS09555
uniprot id: S5TKE0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224163:B841 RS01410
gene id: 1224163:B841_RS01410
uniprot id: S5SRL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1224163:B841 RS12950
gene id: 1224163:B841_RS12950
uniprot id: S5SXQ9
names: Similarity
messages: Belongs to the thioredoxin family.

1224163:B841 RS10405
gene id: 1224163:B841_RS10405
uniprot id: S5TKZ2
names: Similarity
messages: Belongs to the glutamine synthetase family.

1224163:B841 RS04135
gene id: 1224163:B841_RS04135
uniprot id: S5THW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1224163:B841 RS06195
gene id: 1224163:B841_RS06195
uniprot id: S5TIX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1224163:B841 RS01475
gene id: 1224163:B841_RS01475
uniprot id: S5SRW9
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1224163:B841 RS09890
gene id: 1224163:B841_RS09890
uniprot id: S5TKM0
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS01005
gene id: 1224163:B841_RS01005
uniprot id: S5TG78
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1224163:B841 RS09735
gene id: 1224163:B841_RS09735
uniprot id: S5T418
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1224163:B841 RS10060
gene id: 1224163:B841_RS10060
uniprot id: S5TKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1224163:B841 RS01480
gene id: 1224163:B841_RS01480
uniprot id: S5TGG6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS07090
gene id: 1224163:B841_RS07090
uniprot id: S5SUK5
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1224163:B841 RS02715
gene id: 1224163:B841_RS02715
uniprot id: S5SSM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1224163:B841 RS02700
gene id: 1224163:B841_RS02700
uniprot id: S5SSD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1224163:B841 RS10930
gene id: 1224163:B841_RS10930
uniprot id: S5SX09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1224163:B841 RS07295
gene id: 1224163:B841_RS07295
uniprot id: S5T2R8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1224163:B841 RS08265
gene id: 1224163:B841_RS08265
uniprot id: S5TK42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1224163:B841 RS02735
gene id: 1224163:B841_RS02735
uniprot id: S5TGK5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1224163:B841 RS11195
gene id: 1224163:B841_RS11195
uniprot id: S5SX39
names: Similarity
messages: Belongs to the GARS family.

1224163:B841 RS09830
gene id: 1224163:B841_RS09830
uniprot id: S5SW14
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11510
gene id: 1224163:B841_RS11510
uniprot id: S5SWW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS11770
gene id: 1224163:B841_RS11770
uniprot id: S5TLN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1224163:B841 RS00410
gene id: 1224163:B841_RS00410
uniprot id: S5SRF1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1224163:B841 RS00915
gene id: 1224163:B841_RS00915
uniprot id: S5SZG3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1224163:B841 RS09285
gene id: 1224163:B841_RS09285
uniprot id: S5TKS6
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1224163:B841 RS01435
gene id: 1224163:B841_RS01435
uniprot id: S5SRL9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

1224163:B841 RS10345
gene id: 1224163:B841_RS10345
uniprot id: S5SWE2
names: Similarity
names: Subunit
messages: Belongs to the muconolactone Delta-isomerase family.
messages: Homodecamer.

1224163:B841 RS12010
gene id: 1224163:B841_RS12010
uniprot id: S5SX64
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

1224163:B841 RS12985
gene id: 1224163:B841_RS12985
uniprot id: S5TMJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1224163:B841 RS08075
gene id: 1224163:B841_RS08075
uniprot id: S5T367
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1224163:B841 RS04975
gene id: 1224163:B841_RS04975
uniprot id: S5STI3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224163:B841 RS13430
gene id: 1224163:B841_RS13430
uniprot id: S5SVW6
names: Similarity
messages: Belongs to the PrpD family.

1224163:B841 RS06275
gene id: 1224163:B841_RS06275
uniprot id: S5SU62
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS01030
gene id: 1224163:B841_RS01030
uniprot id: S5TG83
names: Similarity
messages: Belongs to the peptidase M13 family.

1224163:B841 RS12980
gene id: 1224163:B841_RS12980
uniprot id: S5T5Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1224163:B841 RS04610
gene id: 1224163:B841_RS04610
uniprot id: S5THI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1224163:B841 RS01955
gene id: 1224163:B841_RS01955
uniprot id: S5SS57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

1224163:B841 RS10340
gene id: 1224163:B841_RS10340
uniprot id: S5TLG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1224163:B841 RS08310
gene id: 1224163:B841_RS08310
uniprot id: S5SVP0
names: Similarity
messages: Belongs to the UPF0102 family.

1224163:B841 RS12525
gene id: 1224163:B841_RS12525
uniprot id: S5SXG0
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS07135
gene id: 1224163:B841_RS07135
uniprot id: S5TJG8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1224163:B841 RS03040
gene id: 1224163:B841_RS03040
uniprot id: S5SSS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS01385
gene id: 1224163:B841_RS01385
uniprot id: S5SRL0
names: Similarity
messages: Belongs to the cytochrome P450 family.

1224163:B841 RS11245
gene id: 1224163:B841_RS11245
uniprot id: S5TLB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

1224163:B841 RS04005
gene id: 1224163:B841_RS04005
uniprot id: S5ST80
names: Similarity
messages: Belongs to the FPG family.

1224163:B841 RS00945
gene id: 1224163:B841_RS00945
uniprot id: S5TFH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

1224163:B841 RS01110
gene id: 1224163:B841_RS01110
uniprot id: S5SRH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1224163:B841 RS02730
gene id: 1224163:B841_RS02730
uniprot id: S5T0G6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1224163:B841 RS01275
gene id: 1224163:B841_RS01275
uniprot id: S5SZN7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS05315
gene id: 1224163:B841_RS05315
uniprot id: S5T1U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1224163:B841 RS04765
gene id: 1224163:B841_RS04765
uniprot id: S5STP4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS00005
gene id: 1224163:B841_RS00005
uniprot id: S5SQZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1224163:B841 RS09875
gene id: 1224163:B841_RS09875
uniprot id: S5TL48
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1224163:B841 RS09950
gene id: 1224163:B841_RS09950
uniprot id: S5TL65
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

1224163:B841 RS11970
gene id: 1224163:B841_RS11970
uniprot id: S5TLT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1224163:B841 RS08030
gene id: 1224163:B841_RS08030
uniprot id: S5TJM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1224163:B841 RS02765
gene id: 1224163:B841_RS02765
uniprot id: S5SSN1
names: Similarity
messages: Belongs to the CFA/CMAS family.

1224163:B841 RS09120
gene id: 1224163:B841_RS09120
uniprot id: S5T3Q2
names: Similarity
messages: Belongs to the glutamine synthetase family.

1224163:B841 RS06265
gene id: 1224163:B841_RS06265
uniprot id: S5SUI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1224163:B841 RS01430
gene id: 1224163:B841_RS01430
uniprot id: S5TGF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1224163:B841 RS02840
gene id: 1224163:B841_RS02840
uniprot id: S5SSP0
names: Similarity
messages: Belongs to the WXG100 family.

1224163:B841 RS12560
gene id: 1224163:B841_RS12560
uniprot id: S5TM91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1224163:B841 RS01350
gene id: 1224163:B841_RS01350
uniprot id: S5TGE6
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

1224163:B841 RS12870
gene id: 1224163:B841_RS12870
uniprot id: S5TMX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1224163:B841 RS10780
gene id: 1224163:B841_RS10780
uniprot id: S5SWK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224163:B841 RS02960
gene id: 1224163:B841_RS02960
uniprot id: S5TGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1224163:B841 RS06345
gene id: 1224163:B841_RS06345
uniprot id: S5SUJ9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224163:B841 RS13495
gene id: 1224163:B841_RS13495
uniprot id: S5T5Z5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1224163:B841 RS08280
gene id: 1224163:B841_RS08280
uniprot id: S5TJQ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1224163:B841 RS07720
gene id: 1224163:B841_RS07720
uniprot id: S5SUZ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS07025
gene id: 1224163:B841_RS07025
uniprot id: S5TJ07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS03755
gene id: 1224163:B841_RS03755
uniprot id: S5SSU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1224163:B841 RS03015
gene id: 1224163:B841_RS03015
uniprot id: S5SSR8
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS09855
gene id: 1224163:B841_RS09855
uniprot id: S5SW21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1224163:B841 RS03880
gene id: 1224163:B841_RS03880
uniprot id: S5TH42
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1224163:B841 RS07255
gene id: 1224163:B841_RS07255
uniprot id: S5SV37
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS02365
gene id: 1224163:B841_RS02365
uniprot id: S5SSE7
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1224163:B841 RS03255
gene id: 1224163:B841_RS03255
uniprot id: S5SSK3
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1224163:B841 RS06475
gene id: 1224163:B841_RS06475
uniprot id: S5TJ36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1224163:B841 RS00955
gene id: 1224163:B841_RS00955
uniprot id: S5TG70
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1224163:B841 RS07815
gene id: 1224163:B841_RS07815
uniprot id: S5TJY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1224163:B841 RS03890
gene id: 1224163:B841_RS03890
uniprot id: S5THR4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1224163:B841 RS07200
gene id: 1224163:B841_RS07200
uniprot id: S5TJ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1224163:B841 RS03540
gene id: 1224163:B841_RS03540
uniprot id: S5ST05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1224163:B841 RS07245
gene id: 1224163:B841_RS07245
uniprot id: S5T2Q8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1224163:B841 RS01880
gene id: 1224163:B841_RS01880
uniprot id: S5SS41
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1224163:B841 RS08465
gene id: 1224163:B841_RS08465
uniprot id: S5TK81
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1224163:B841 RS08440
gene id: 1224163:B841_RS08440
uniprot id: S5TK75
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS12145
gene id: 1224163:B841_RS12145
uniprot id: S5TLY8
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224163:B841 RS02630
gene id: 1224163:B841_RS02630
uniprot id: S5T0F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1224163:B841 RS07310
gene id: 1224163:B841_RS07310
uniprot id: S5TJL3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1224163:B841 RS11300
gene id: 1224163:B841_RS11300
uniprot id: S5SX57
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224163:B841 RS13780
gene id: 1224163:B841_RS13780
uniprot id: S5TG95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
messages: Belongs to the emb family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS02725
gene id: 1224163:B841_RS02725
uniprot id: S5SSD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1224163:B841 RS08850
gene id: 1224163:B841_RS08850
uniprot id: S5TK01
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1224163:B841 RS00415
gene id: 1224163:B841_RS00415
uniprot id: S5TFY0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224163:B841 RS00095
gene id: 1224163:B841_RS00095
uniprot id: S5SZ30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1224163:B841 RS09840
gene id: 1224163:B841_RS09840
uniprot id: S5TKK6
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1224163:B841 RS05690
gene id: 1224163:B841_RS05690
uniprot id: S5SU84
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1224163:B841 RS07225
gene id: 1224163:B841_RS07225
uniprot id: S5TJ57
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1224163:B841 RS11520
gene id: 1224163:B841_RS11520
uniprot id: S5TLI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1224163:B841 RS10450
gene id: 1224163:B841_RS10450
uniprot id: S5TLI8
names: Similarity
messages: Belongs to the peptidase M1 family.

1224163:B841 RS02920
gene id: 1224163:B841_RS02920
uniprot id: S5TH97
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1224163:B841 RS08460
gene id: 1224163:B841_RS08460
uniprot id: S5SVR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1224163:B841 RS02950
gene id: 1224163:B841_RS02950
uniprot id: S5SSG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1224163:B841 RS01330
gene id: 1224163:B841_RS01330
uniprot id: S5SRK2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS11025
gene id: 1224163:B841_RS11025
uniprot id: S5TLR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1224163:B841 RS12745
gene id: 1224163:B841_RS12745
uniprot id: S5SXX7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS10015
gene id: 1224163:B841_RS10015
uniprot id: S5TKP8
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

1224163:B841 RS03725
gene id: 1224163:B841_RS03725
uniprot id: S5THN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1224163:B841 RS10230
gene id: 1224163:B841_RS10230
uniprot id: S5T4H0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1224163:B841 RS02520
gene id: 1224163:B841_RS02520
uniprot id: S5TH40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1224163:B841 RS02600
gene id: 1224163:B841_RS02600
uniprot id: S5SSB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1224163:B841 RS05460
gene id: 1224163:B841_RS05460
uniprot id: S5T1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS09265
gene id: 1224163:B841_RS09265
uniprot id: S5T3T4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS06905
gene id: 1224163:B841_RS06905
uniprot id: S5TJC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1224163:B841 RS07735
gene id: 1224163:B841_RS07735
uniprot id: S5SVF6
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1224163:B841 RS06490
gene id: 1224163:B841_RS06490
uniprot id: S5TIM9
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1224163:B841 RS08645
gene id: 1224163:B841_RS08645
uniprot id: S5SVD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1224163:B841 RS12625
gene id: 1224163:B841_RS12625
uniprot id: S5SXI4
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1224163:B841 RS11905
gene id: 1224163:B841_RS11905
uniprot id: S5TM96
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1224163:B841 RS04085
gene id: 1224163:B841_RS04085
uniprot id: S5THV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1224163:B841 RS05505
gene id: 1224163:B841_RS05505
uniprot id: S5T1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1224163:B841 RS02420
gene id: 1224163:B841_RS02420
uniprot id: S5SS66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1224163:B841 RS01640
gene id: 1224163:B841_RS01640
uniprot id: S5SZV7
names: Subcellular Location Annotation
messages: Cytoplasm

1224163:B841 RS06440
gene id: 1224163:B841_RS06440
uniprot id: S5TIL8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1224163:B841 RS10455
gene id: 1224163:B841_RS10455
uniprot id: S5SWF8
names: Similarity
messages: Belongs to the DszC flavin monooxygenase family.

1224163:B841 RS04230
gene id: 1224163:B841_RS04230
uniprot id: S5THA0
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1224163:B841 RS02505
gene id: 1224163:B841_RS02505
uniprot id: S5T0C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1224163:B841 RS05650
gene id: 1224163:B841_RS05650
uniprot id: S5TIP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1224163:B841 RS06580
gene id: 1224163:B841_RS06580
uniprot id: S5SUN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1224163:B841 RS01705
gene id: 1224163:B841_RS01705
uniprot id: S5SS08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS10815
gene id: 1224163:B841_RS10815
uniprot id: S5TL56
names: Similarity
messages: Belongs to the peptidase S58 family.

1224163:B841 RS08425
gene id: 1224163:B841_RS08425
uniprot id: S5T3C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS01765
gene id: 1224163:B841_RS01765
uniprot id: S5SRS9
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1224163:B841 RS07840
gene id: 1224163:B841_RS07840
uniprot id: S5TJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1224163:B841 RS10325
gene id: 1224163:B841_RS10325
uniprot id: S5T4I7
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1224163:B841 RS07345
gene id: 1224163:B841_RS07345
uniprot id: S5T2T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1224163:B841 RS10625
gene id: 1224163:B841_RS10625
uniprot id: S5SWX5
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

1224163:B841 RS02425
gene id: 1224163:B841_RS02425
uniprot id: S5T0A3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1224163:B841 RS03545
gene id: 1224163:B841_RS03545
uniprot id: S5THJ8
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1224163:B841 RS08035
gene id: 1224163:B841_RS08035
uniprot id: S5SVJ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS00025
gene id: 1224163:B841_RS00025
uniprot id: S5TFR9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1224163:B841 RS08575
gene id: 1224163:B841_RS08575
uniprot id: S5T3E3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS11565
gene id: 1224163:B841_RS11565
uniprot id: S5T534
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS07440
gene id: 1224163:B841_RS07440
uniprot id: S5SUS5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1224163:B841 RS11710
gene id: 1224163:B841_RS11710
uniprot id: S5SX10
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1224163:B841 RS05950
gene id: 1224163:B841_RS05950
uniprot id: S5SU15
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1224163:B841 RS10540
gene id: 1224163:B841_RS10540
uniprot id: S5TL12
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1224163:B841 RS03710
gene id: 1224163:B841_RS03710
uniprot id: S5T0Y3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1224163:B841 RS12440
gene id: 1224163:B841_RS12440
uniprot id: S5T5L6
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02370
gene id: 1224163:B841_RS02370
uniprot id: S5TH02
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1224163:B841 RS04675
gene id: 1224163:B841_RS04675
uniprot id: S5STC2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1224163:B841 RS10365
gene id: 1224163:B841_RS10365
uniprot id: S5TLH6
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

1224163:B841 RS02375
gene id: 1224163:B841_RS02375
uniprot id: S5SS54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1224163:B841 RS04785
gene id: 1224163:B841_RS04785
uniprot id: S5THN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1224163:B841 RS09195
gene id: 1224163:B841_RS09195
uniprot id: S5TK56
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1224163:B841 RS07165
gene id: 1224163:B841_RS07165
uniprot id: S5SUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1224163:B841 RS04155
gene id: 1224163:B841_RS04155
uniprot id: S5STB8
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1224163:B841 RS10965
gene id: 1224163:B841_RS10965
uniprot id: S5TL78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS03585
gene id: 1224163:B841_RS03585
uniprot id: S5TGZ8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224163:B841 RS02235
gene id: 1224163:B841_RS02235
uniprot id: S5T072
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS11040
gene id: 1224163:B841_RS11040
uniprot id: S5TL86
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1224163:B841 RS03485
gene id: 1224163:B841_RS03485
uniprot id: S5TGY2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1224163:B841 RS09170
gene id: 1224163:B841_RS09170
uniprot id: S5TK54
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1224163:B841 RS05735
gene id: 1224163:B841_RS05735
uniprot id: S5TI99
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

1224163:B841 RS12860
gene id: 1224163:B841_RS12860
uniprot id: S5TMH4
names: Function
names: Similarity
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

1224163:B841 RS02925
gene id: 1224163:B841_RS02925
uniprot id: S5SSG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

1224163:B841 RS11010
gene id: 1224163:B841_RS11010
uniprot id: S5TL82
names: Similarity
messages: Belongs to the CsoR family.

1224163:B841 RS04980
gene id: 1224163:B841_RS04980
uniprot id: S5T1M3
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS12605
gene id: 1224163:B841_RS12605
uniprot id: S5T5Q3
names: Similarity
messages: Belongs to the UPF0371 family.

1224163:B841 RS07280
gene id: 1224163:B841_RS07280
uniprot id: S5SV42
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1224163:B841 RS10600
gene id: 1224163:B841_RS10600
uniprot id: S5SWX2
names: Function
names: Similarity
messages: Belongs to the LarC family.
messages: Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.

1224163:B841 RS12600
gene id: 1224163:B841_RS12600
uniprot id: S5SXH6
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1224163:B841 RS05110
gene id: 1224163:B841_RS05110
uniprot id: S5THZ5
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

1224163:B841 RS08250
gene id: 1224163:B841_RS08250
uniprot id: S5T391
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1224163:B841 RS10030
gene id: 1224163:B841_RS10030
uniprot id: S5SW62
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1224163:B841 RS07330
gene id: 1224163:B841_RS07330
uniprot id: S5SV55
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1224163:B841 RS08230
gene id: 1224163:B841_RS08230
uniprot id: S5TJQ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1224163:B841 RS10090
gene id: 1224163:B841_RS10090
uniprot id: S5SWM4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS07175
gene id: 1224163:B841_RS07175
uniprot id: S5TJ44
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224163:B841 RS11475
gene id: 1224163:B841_RS11475
uniprot id: S5SX83
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1224163:B841 RS10875
gene id: 1224163:B841_RS10875
uniprot id: S5TLP9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1224163:B841 RS07555
gene id: 1224163:B841_RS07555
uniprot id: S5SVB1
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

1224163:B841 RS12355
gene id: 1224163:B841_RS12355
uniprot id: S5TMJ2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

1224163:B841 RS06470
gene id: 1224163:B841_RS06470
uniprot id: S5SUM0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1224163:B841 RS09175
gene id: 1224163:B841_RS09175
uniprot id: S5SW29
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03125
gene id: 1224163:B841_RS03125
uniprot id: S5SSI6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1224163:B841 RS07140
gene id: 1224163:B841_RS07140
uniprot id: S5SUL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1224163:B841 RS06685
gene id: 1224163:B841_RS06685
uniprot id: S5SUQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1224163:B841 RS10585
gene id: 1224163:B841_RS10585
uniprot id: S5SWH5
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS07130
gene id: 1224163:B841_RS07130
uniprot id: S5SV05
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS09310
gene id: 1224163:B841_RS09310
uniprot id: S5TKS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS02685
gene id: 1224163:B841_RS02685
uniprot id: S5TGJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1224163:B841 RS07465
gene id: 1224163:B841_RS07465
uniprot id: S5SUT1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1224163:B841 RS07230
gene id: 1224163:B841_RS07230
uniprot id: S5SV30
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1224163:B841 RS09985
gene id: 1224163:B841_RS09985
uniprot id: S5T488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS08640
gene id: 1224163:B841_RS08640
uniprot id: S5TKD1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1224163:B841 RS03140
gene id: 1224163:B841_RS03140
uniprot id: S5SST9
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1224163:B841 RS08485
gene id: 1224163:B841_RS08485
uniprot id: S5SVR6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224163:B841 RS11050
gene id: 1224163:B841_RS11050
uniprot id: S5TLS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1224163:B841 RS08125
gene id: 1224163:B841_RS08125
uniprot id: S5T374
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1224163:B841 RS13315
gene id: 1224163:B841_RS13315
uniprot id: S5STJ6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1224163:B841 RS05795
gene id: 1224163:B841_RS05795
uniprot id: S5TIR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1224163:B841 RS12060
gene id: 1224163:B841_RS12060
uniprot id: S5SX74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1224163:B841 RS10130
gene id: 1224163:B841_RS10130
uniprot id: S5T4E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1224163:B841 RS10195
gene id: 1224163:B841_RS10195
uniprot id: S5TLD8
names: Similarity
messages: Belongs to the pirin family.

1224163:B841 RS07930
gene id: 1224163:B841_RS07930
uniprot id: S5TJK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS00715
gene id: 1224163:B841_RS00715
uniprot id: S5SZC3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1224163:B841 RS05170
gene id: 1224163:B841_RS05170
uniprot id: S5TI03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

1224163:B841 RS00345
gene id: 1224163:B841_RS00345
uniprot id: S5SR45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS03495
gene id: 1224163:B841_RS03495
uniprot id: S5THI9
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1224163:B841 RS02310
gene id: 1224163:B841_RS02310
uniprot id: S5T085
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1224163:B841 RS05800
gene id: 1224163:B841_RS05800
uniprot id: S5STY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1224163:B841 RS06740
gene id: 1224163:B841_RS06740
uniprot id: S5TJ89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1224163:B841 RS03550
gene id: 1224163:B841_RS03550
uniprot id: S5SSQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1224163:B841 RS09925
gene id: 1224163:B841_RS09925
uniprot id: S5TL58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

1224163:B841 RS11730
gene id: 1224163:B841_RS11730
uniprot id: S5TM53
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS05510
gene id: 1224163:B841_RS05510
uniprot id: S5TI60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

1224163:B841 RS10150
gene id: 1224163:B841_RS10150
uniprot id: S5SW96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1224163:B841 RS07960
gene id: 1224163:B841_RS07960
uniprot id: S5SVI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1224163:B841 RS11145
gene id: 1224163:B841_RS11145
uniprot id: S5SX32
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1224163:B841 RS01950
gene id: 1224163:B841_RS01950
uniprot id: S5TG00
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1224163:B841 RS00615
gene id: 1224163:B841_RS00615
uniprot id: S5TG10
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1224163:B841 RS09685
gene id: 1224163:B841_RS09685
uniprot id: S5TKH2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

1224163:B841 RS05860
gene id: 1224163:B841_RS05860
uniprot id: S5TIC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

1224163:B841 RS10565
gene id: 1224163:B841_RS10565
uniprot id: S5T4M5
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03175
gene id: 1224163:B841_RS03175
uniprot id: S5THD4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

1224163:B841 RS02665
gene id: 1224163:B841_RS02665
uniprot id: S5SSM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1224163:B841 RS06930
gene id: 1224163:B841_RS06930
uniprot id: S5TJD3
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1224163:B841 RS11470
gene id: 1224163:B841_RS11470
uniprot id: S5TLG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1224163:B841 RS05580
gene id: 1224163:B841_RS05580
uniprot id: S5T1X4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02265
gene id: 1224163:B841_RS02265
uniprot id: S5TG85
names: Similarity
messages: Belongs to the YjdM family.

1224163:B841 RS06420
gene id: 1224163:B841_RS06420
uniprot id: S5SUL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1224163:B841 RS00420
gene id: 1224163:B841_RS00420
uniprot id: S5SR58
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224163:B841 RS03215
gene id: 1224163:B841_RS03215
uniprot id: S5TGU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224163:B841 RS06975
gene id: 1224163:B841_RS06975
uniprot id: S5SUX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1224163:B841 RS11965
gene id: 1224163:B841_RS11965
uniprot id: S5T5B3
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1224163:B841 RS04720
gene id: 1224163:B841_RS04720
uniprot id: S5TI67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1224163:B841 RS07055
gene id: 1224163:B841_RS07055
uniprot id: S5SUY6
names: Similarity
messages: Belongs to the UPF0237 family.

1224163:B841 RS01645
gene id: 1224163:B841_RS01645
uniprot id: S5TFT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS02905
gene id: 1224163:B841_RS02905
uniprot id: S5T0I8
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11665
gene id: 1224163:B841_RS11665
uniprot id: S5T555
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02390
gene id: 1224163:B841_RS02390
uniprot id: S5SSF3
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02930
gene id: 1224163:B841_RS02930
uniprot id: S5T0J2
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1224163:B841 RS06900
gene id: 1224163:B841_RS06900
uniprot id: S5SUV7
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

1224163:B841 RS11320
gene id: 1224163:B841_RS11320
uniprot id: S5TLD3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1224163:B841 RS08620
gene id: 1224163:B841_RS08620
uniprot id: S5SVD4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1224163:B841 RS12760
gene id: 1224163:B841_RS12760
uniprot id: S5T5V5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS00790
gene id: 1224163:B841_RS00790
uniprot id: S5SZD8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1224163:B841 RS11455
gene id: 1224163:B841_RS11455
uniprot id: S5TLZ8
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1224163:B841 RS05275
gene id: 1224163:B841_RS05275
uniprot id: S5SU10
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MshB deacetylase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.

1224163:B841 RS04840
gene id: 1224163:B841_RS04840
uniprot id: S5STR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS11425
gene id: 1224163:B841_RS11425
uniprot id: S5SX77
names: Similarity
messages: Belongs to the pantothenate synthetase family.

1224163:B841 RS00010
gene id: 1224163:B841_RS00010
uniprot id: S5SZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1224163:B841 RS00460
gene id: 1224163:B841_RS00460
uniprot id: S5SRG0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224163:B841 RS13815
gene id: 1224163:B841_RS13815
uniprot id: S5SS30
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS05750
gene id: 1224163:B841_RS05750
uniprot id: S5STY0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1224163:B841 RS10415
gene id: 1224163:B841_RS10415
uniprot id: S5TLI5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1224163:B841 RS01115
gene id: 1224163:B841_RS01115
uniprot id: S5SZK6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1224163:B841 RS08025
gene id: 1224163:B841_RS08025
uniprot id: S5T360
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1224163:B841 RS03130
gene id: 1224163:B841_RS03130
uniprot id: S5T0N0
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1224163:B841 RS00695
gene id: 1224163:B841_RS00695
uniprot id: S5TFC7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1224163:B841 RS05085
gene id: 1224163:B841_RS05085
uniprot id: S5THY9
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.

1224163:B841 RS06000
gene id: 1224163:B841_RS06000
uniprot id: S5SU24
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02745
gene id: 1224163:B841_RS02745
uniprot id: S5TH74
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS10400
gene id: 1224163:B841_RS10400
uniprot id: S5T4K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224163:B841 RS08165
gene id: 1224163:B841_RS08165
uniprot id: S5TK28
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS06920
gene id: 1224163:B841_RS06920
uniprot id: S5TIY1
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1224163:B841 RS10295
gene id: 1224163:B841_RS10295
uniprot id: S5SWD6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224163:B841 RS02860
gene id: 1224163:B841_RS02860
uniprot id: S5TGM4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1224163:B841 RS09815
gene id: 1224163:B841_RS09815
uniprot id: S5TKK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS03670
gene id: 1224163:B841_RS03670
uniprot id: S5THM2
names: Similarity
messages: Belongs to the peptidase S16 family.

1224163:B841 RS00260
gene id: 1224163:B841_RS00260
uniprot id: S5SRC8
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS08190
gene id: 1224163:B841_RS08190
uniprot id: S5TK32
names: Similarity
messages: Belongs to the MQO family.

1224163:B841 RS00675
gene id: 1224163:B841_RS00675
uniprot id: S5SRJ3
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03220
gene id: 1224163:B841_RS03220
uniprot id: S5SSV1
names: Cofactor
messages: Can also use Mn(2+) ion.

1224163:B841 RS12910
gene id: 1224163:B841_RS12910
uniprot id: S5TMI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1224163:B841 RS12855
gene id: 1224163:B841_RS12855
uniprot id: S5T5X1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS05775
gene id: 1224163:B841_RS05775
uniprot id: S5STY4
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1224163:B841 RS01180
gene id: 1224163:B841_RS01180
uniprot id: S5SRI3
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02690
gene id: 1224163:B841_RS02690
uniprot id: S5SSM3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224163:B841 RS00480
gene id: 1224163:B841_RS00480
uniprot id: S5TF87
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224163:B841 RS01825
gene id: 1224163:B841_RS01825
uniprot id: S5TFX1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1224163:B841 RS01340
gene id: 1224163:B841_RS01340
uniprot id: S5TFN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS10790
gene id: 1224163:B841_RS10790
uniprot id: S5TL51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1224163:B841 RS02845
gene id: 1224163:B841_RS02845
uniprot id: S5TH85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1224163:B841 RS06955
gene id: 1224163:B841_RS06955
uniprot id: S5TJD7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1224163:B841 RS00125
gene id: 1224163:B841_RS00125
uniprot id: S5TF27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1224163:B841 RS04070
gene id: 1224163:B841_RS04070
uniprot id: S5T147
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1224163:B841 RS02335
gene id: 1224163:B841_RS02335
uniprot id: S5T089
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1224163:B841 RS08300
gene id: 1224163:B841_RS08300
uniprot id: S5T397
names: Similarity
messages: Belongs to the DprA/Smf family.

1224163:B841 RS01570
gene id: 1224163:B841_RS01570
uniprot id: S5TFS0
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

1224163:B841 RS03310
gene id: 1224163:B841_RS03310
uniprot id: S5T0R1
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03865
gene id: 1224163:B841_RS03865
uniprot id: S5THQ9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224163:B841 RS01510
gene id: 1224163:B841_RS01510
uniprot id: S5SRM9
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1224163:B841 RS12790
gene id: 1224163:B841_RS12790
uniprot id: S5TMF7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224163:B841 RS02945
gene id: 1224163:B841_RS02945
uniprot id: S5THA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

1224163:B841 RS01980
gene id: 1224163:B841_RS01980
uniprot id: S5SS63
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS05785
gene id: 1224163:B841_RS05785
uniprot id: S5TIA7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS01560
gene id: 1224163:B841_RS01560
uniprot id: S5SRN8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1224163:B841 RS00725
gene id: 1224163:B841_RS00725
uniprot id: S5SRK1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224163:B841 RS05005
gene id: 1224163:B841_RS05005
uniprot id: S5T1M8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1224163:B841 RS00665
gene id: 1224163:B841_RS00665
uniprot id: S5SZB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224163:B841 RS02680
gene id: 1224163:B841_RS02680
uniprot id: S5T0G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1224163:B841 RS05840
gene id: 1224163:B841_RS05840
uniprot id: S5SUB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1224163:B841 RS01820
gene id: 1224163:B841_RS01820
uniprot id: S5SZZ3
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1224163:B841 RS05885
gene id: 1224163:B841_RS05885
uniprot id: S5TIC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224163:B841 RS12400
gene id: 1224163:B841_RS12400
uniprot id: S5SXP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1224163:B841 RS03160
gene id: 1224163:B841_RS03160
uniprot id: S5T0N4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS11485
gene id: 1224163:B841_RS11485
uniprot id: S5SWW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1224163:B841 RS11785
gene id: 1224163:B841_RS11785
uniprot id: S5SX27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

1224163:B841 RS08510
gene id: 1224163:B841_RS08510
uniprot id: S5SVR9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1224163:B841 RS04100
gene id: 1224163:B841_RS04100
uniprot id: S5TH75
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1224163:B841 RS00890
gene id: 1224163:B841_RS00890
uniprot id: S5SZF8
names: Similarity
messages: Belongs to the YciI family.

1224163:B841 RS03250
gene id: 1224163:B841_RS03250
uniprot id: S5THE8
names: Similarity
messages: Belongs to the citrate synthase family.

1224163:B841 RS00115
gene id: 1224163:B841_RS00115
uniprot id: S5SR12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1224163:B841 RS07145
gene id: 1224163:B841_RS07145
uniprot id: S5T2N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1224163:B841 RS05855
gene id: 1224163:B841_RS05855
uniprot id: S5T219
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1224163:B841 RS03195
gene id: 1224163:B841_RS03195
uniprot id: S5SSU6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1224163:B841 RS00400
gene id: 1224163:B841_RS00400
uniprot id: S5SZ69
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224163:B841 RS02570
gene id: 1224163:B841_RS02570
uniprot id: S5TH51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1224163:B841 RS04550
gene id: 1224163:B841_RS04550
uniprot id: S5THH3
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

1224163:B841 RS11185
gene id: 1224163:B841_RS11185
uniprot id: S5T4W8
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1224163:B841 RS02560
gene id: 1224163:B841_RS02560
uniprot id: S5TGH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1224163:B841 RS03395
gene id: 1224163:B841_RS03395
uniprot id: S5THH4
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224163:B841 RS00450
gene id: 1224163:B841_RS00450
uniprot id: S5SZ76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS10550
gene id: 1224163:B841_RS10550
uniprot id: S5TLK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224163:B841 RS08275
gene id: 1224163:B841_RS08275
uniprot id: S5T394
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1224163:B841 RS10185
gene id: 1224163:B841_RS10185
uniprot id: S5TKV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1224163:B841 RS06395
gene id: 1224163:B841_RS06395
uniprot id: S5SUK8
names: Similarity
messages: Belongs to the universal stress protein A family.

1224163:B841 RS09395
gene id: 1224163:B841_RS09395
uniprot id: S5T3V7
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1224163:B841 RS00750
gene id: 1224163:B841_RS00750
uniprot id: S5SRK4
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1224163:B841 RS12995
gene id: 1224163:B841_RS12995
uniprot id: S5TMZ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1224163:B841 RS03240
gene id: 1224163:B841_RS03240
uniprot id: S5TGU5
names: Similarity
messages: Belongs to the PrpD family.

1224163:B841 RS08685
gene id: 1224163:B841_RS08685
uniprot id: S5SVU5
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03225
gene id: 1224163:B841_RS03225
uniprot id: S5THE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1224163:B841 RS09655
gene id: 1224163:B841_RS09655
uniprot id: S5T403
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1224163:B841 RS08110
gene id: 1224163:B841_RS08110
uniprot id: S5SVK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1224163:B841 RS01605
gene id: 1224163:B841_RS01605
uniprot id: S5TGJ2
names: Similarity
messages: Belongs to the GSP E family.

1224163:B841 RS03050
gene id: 1224163:B841_RS03050
uniprot id: S5SSH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1224163:B841 RS01540
gene id: 1224163:B841_RS01540
uniprot id: S5SRN4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224163:B841 RS02275
gene id: 1224163:B841_RS02275
uniprot id: S5TGY5
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS07845
gene id: 1224163:B841_RS07845
uniprot id: S5SV18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1224163:B841 RS08880
gene id: 1224163:B841_RS08880
uniprot id: S5SVY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1224163:B841 RS07380
gene id: 1224163:B841_RS07380
uniprot id: S5SV68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1224163:B841 RS08055
gene id: 1224163:B841_RS08055
uniprot id: S5TJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1224163:B841 RS11855
gene id: 1224163:B841_RS11855
uniprot id: S5TM84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1224163:B841 RS09550
gene id: 1224163:B841_RS09550
uniprot id: S5T3Y5
names: Similarity
messages: Belongs to the cytochrome P450 family.

1224163:B841 RS02595
gene id: 1224163:B841_RS02595
uniprot id: S5TH57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1224163:B841 RS08555
gene id: 1224163:B841_RS08555
uniprot id: S5TJU7
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

1224163:B841 RS05900
gene id: 1224163:B841_RS05900
uniprot id: S5SU07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS02060
gene id: 1224163:B841_RS02060
uniprot id: S5SRY9
names: Similarity
messages: Belongs to the CsoR family.

1224163:B841 RS06480
gene id: 1224163:B841_RS06480
uniprot id: S5SU94
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1224163:B841 RS02580
gene id: 1224163:B841_RS02580
uniprot id: S5T0E6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1224163:B841 RS03315
gene id: 1224163:B841_RS03315
uniprot id: S5TGV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224163:B841 RS12620
gene id: 1224163:B841_RS12620
uniprot id: S5TMQ2
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS09085
gene id: 1224163:B841_RS09085
uniprot id: S5TKP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1224163:B841 RS06960
gene id: 1224163:B841_RS06960
uniprot id: S5SUI0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1224163:B841 RS07210
gene id: 1224163:B841_RS07210
uniprot id: S5TJI6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1224163:B841 RS06820
gene id: 1224163:B841_RS06820
uniprot id: S5TIV4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1224163:B841 RS12845
gene id: 1224163:B841_RS12845
uniprot id: S5TMW8
names: Cofactor
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.

1224163:B841 RS09520
gene id: 1224163:B841_RS09520
uniprot id: S5SVV6
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS12135
gene id: 1224163:B841_RS12135
uniprot id: S5SX89
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS12535
gene id: 1224163:B841_RS12535
uniprot id: S5TM85
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1224163:B841 RS03650
gene id: 1224163:B841_RS03650
uniprot id: S5SSS4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1224163:B841 RS04090
gene id: 1224163:B841_RS04090
uniprot id: S5ST07
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1224163:B841 RS03795
gene id: 1224163:B841_RS03795
uniprot id: S5SSU7
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1224163:B841 RS01375
gene id: 1224163:B841_RS01375
uniprot id: S5SRV2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1224163:B841 RS05130
gene id: 1224163:B841_RS05130
uniprot id: S5STM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

1224163:B841 RS13335
gene id: 1224163:B841_RS13335
uniprot id: S5T2C4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS08385
gene id: 1224163:B841_RS08385
uniprot id: S5SVQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1224163:B841 RS03165
gene id: 1224163:B841_RS03165
uniprot id: S5TGT4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS08905
gene id: 1224163:B841_RS08905
uniprot id: S5SVY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1224163:B841 RS02510
gene id: 1224163:B841_RS02510
uniprot id: S5TGF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1224163:B841 RS10655
gene id: 1224163:B841_RS10655
uniprot id: S5SWX9
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1224163:B841 RS07825
gene id: 1224163:B841_RS07825
uniprot id: S5T332
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1224163:B841 RS07385
gene id: 1224163:B841_RS07385
uniprot id: S5TJN4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1224163:B841 RS04625
gene id: 1224163:B841_RS04625
uniprot id: S5STB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS05285
gene id: 1224163:B841_RS05285
uniprot id: S5STQ2
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1224163:B841 RS08560
gene id: 1224163:B841_RS08560
uniprot id: S5SVS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1224163:B841 RS11615
gene id: 1224163:B841_RS11615
uniprot id: S5T542
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1224163:B841 RS07515
gene id: 1224163:B841_RS07515
uniprot id: S5SUU2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1224163:B841 RS00305
gene id: 1224163:B841_RS00305
uniprot id: S5TF56
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS07185
gene id: 1224163:B841_RS07185
uniprot id: S5TJI0
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1224163:B841 RS07060
gene id: 1224163:B841_RS07060
uniprot id: S5TJF6
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

1224163:B841 RS08180
gene id: 1224163:B841_RS08180
uniprot id: S5TJP3
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1224163:B841 RS06935
gene id: 1224163:B841_RS06935
uniprot id: S5SUH4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1224163:B841 RS10160
gene id: 1224163:B841_RS10160
uniprot id: S5TKV0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1224163:B841 RS09470
gene id: 1224163:B841_RS09470
uniprot id: S5T3W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1224163:B841 RS06980
gene id: 1224163:B841_RS06980
uniprot id: S5TJE2
names: Similarity
messages: Belongs to the UPF0098 family.

1224163:B841 RS12350
gene id: 1224163:B841_RS12350
uniprot id: S5SXN3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1224163:B841 RS02080
gene id: 1224163:B841_RS02080
uniprot id: S5SRZ3
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1224163:B841 RS05200
gene id: 1224163:B841_RS05200
uniprot id: S5SU00
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224163:B841 RS05670
gene id: 1224163:B841_RS05670
uniprot id: S5TIP4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1224163:B841 RS06870
gene id: 1224163:B841_RS06870
uniprot id: S5TIW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1224163:B841 RS02620
gene id: 1224163:B841_RS02620
uniprot id: S5TH60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1224163:B841 RS11640
gene id: 1224163:B841_RS11640
uniprot id: S5T550
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1224163:B841 RS10010
gene id: 1224163:B841_RS10010
uniprot id: S5T495
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS06940
gene id: 1224163:B841_RS06940
uniprot id: S5T2J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1224163:B841 RS10675
gene id: 1224163:B841_RS10675
uniprot id: S5T4P1
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1224163:B841 RS01335
gene id: 1224163:B841_RS01335
uniprot id: S5SZP7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1224163:B841 RS02140
gene id: 1224163:B841_RS02140
uniprot id: S5TG52
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1224163:B841 RS03410
gene id: 1224163:B841_RS03410
uniprot id: S5TGX1
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02565
gene id: 1224163:B841_RS02565
uniprot id: S5SSK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1224163:B841 RS07270
gene id: 1224163:B841_RS07270
uniprot id: S5T2R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1224163:B841 RS12120
gene id: 1224163:B841_RS12120
uniprot id: S5TLX9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

1224163:B841 RS05360
gene id: 1224163:B841_RS05360
uniprot id: S5T1U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

1224163:B841 RS10040
gene id: 1224163:B841_RS10040
uniprot id: S5TKQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1224163:B841 RS06205
gene id: 1224163:B841_RS06205
uniprot id: S5T276
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1224163:B841 RS10865
gene id: 1224163:B841_RS10865
uniprot id: S5TL67
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1224163:B841 RS08120
gene id: 1224163:B841_RS08120
uniprot id: S5SV59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1224163:B841 RS10720
gene id: 1224163:B841_RS10720
uniprot id: S5TLM4
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

1224163:B841 RS07335
gene id: 1224163:B841_RS07335
uniprot id: S5TJM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1224163:B841 RS01310
gene id: 1224163:B841_RS01310
uniprot id: S5TFM8
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1224163:B841 RS04725
gene id: 1224163:B841_RS04725
uniprot id: S5STD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1224163:B841 RS00860
gene id: 1224163:B841_RS00860
uniprot id: S5SRC6
names: Subcellular Location Annotation
messages: Cytoplasm

1224163:B841 RS02710
gene id: 1224163:B841_RS02710
uniprot id: S5TGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1224163:B841 RS09045
gene id: 1224163:B841_RS09045
uniprot id: S5T3N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1224163:B841 RS07180
gene id: 1224163:B841_RS07180
uniprot id: S5SV17
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1224163:B841 RS07160
gene id: 1224163:B841_RS07160
uniprot id: S5TJH3
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1224163:B841 RS01240
gene id: 1224163:B841_RS01240
uniprot id: S5SZN1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1224163:B841 RS09450
gene id: 1224163:B841_RS09450
uniprot id: S5TKB7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1224163:B841 RS12070
gene id: 1224163:B841_RS12070
uniprot id: S5T5D3
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

1224163:B841 RS02175
gene id: 1224163:B841_RS02175
uniprot id: S5TGW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1224163:B841 RS09825
gene id: 1224163:B841_RS09825
uniprot id: S5TL37
names: Similarity
messages: Belongs to the Fur family.

1224163:B841 RS04680
gene id: 1224163:B841_RS04680
uniprot id: S5T1G6
names: Similarity
messages: Belongs to the FBPase class 2 family.

1224163:B841 RS03120
gene id: 1224163:B841_RS03120
uniprot id: S5THC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1224163:B841 RS06400
gene id: 1224163:B841_RS06400
uniprot id: S5TJ20
names: Similarity
messages: Belongs to the universal stress protein A family.

1224163:B841 RS03420
gene id: 1224163:B841_RS03420
uniprot id: S5THH9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1224163:B841 RS02995
gene id: 1224163:B841_RS02995
uniprot id: S5THA7
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1224163:B841 RS00555
gene id: 1224163:B841_RS00555
uniprot id: S5TF99
names: Subcellular Location Annotation
messages: Secreted

1224163:B841 RS08340
gene id: 1224163:B841_RS08340
uniprot id: S5TK59
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1224163:B841 RS11240
gene id: 1224163:B841_RS11240
uniprot id: S5T4Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

1224163:B841 RS11080
gene id: 1224163:B841_RS11080
uniprot id: S5SWP0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224163:B841 RS02280
gene id: 1224163:B841_RS02280
uniprot id: S5SS34
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1224163:B841 RS10975
gene id: 1224163:B841_RS10975
uniprot id: S5TLR3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1224163:B841 RS06055
gene id: 1224163:B841_RS06055
uniprot id: S5T254
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS09200
gene id: 1224163:B841_RS09200
uniprot id: S5SW32
names: Similarity
messages: Belongs to the glutamine synthetase family.

1224163:B841 RS09095
gene id: 1224163:B841_RS09095
uniprot id: S5T3P8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1224163:B841 RS06615
gene id: 1224163:B841_RS06615
uniprot id: S5SUB6
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1224163:B841 RS01400
gene id: 1224163:B841_RS01400
uniprot id: S5SRV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1224163:B841 RS01370
gene id: 1224163:B841_RS01370
uniprot id: S5TFN6
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1224163:B841 RS06640
gene id: 1224163:B841_RS06640
uniprot id: S5SUB9
names: Subcellular Location Annotation
messages: Secreted

1224163:B841 RS07500
gene id: 1224163:B841_RS07500
uniprot id: S5TJC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1224163:B841 RS07495
gene id: 1224163:B841_RS07495
uniprot id: S5T2W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1224163:B841 RS04845
gene id: 1224163:B841_RS04845
uniprot id: S5TI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS02325
gene id: 1224163:B841_RS02325
uniprot id: S5TGZ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1224163:B841 RS02590
gene id: 1224163:B841_RS02590
uniprot id: S5SSL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1224163:B841 RS05825
gene id: 1224163:B841_RS05825
uniprot id: S5STZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1224163:B841 RS06220
gene id: 1224163:B841_RS06220
uniprot id: S5TIX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1224163:B841 RS04885
gene id: 1224163:B841_RS04885
uniprot id: S5THR0
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1224163:B841 RS08875
gene id: 1224163:B841_RS08875
uniprot id: S5TK06
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1224163:B841 RS00405
gene id: 1224163:B841_RS00405
uniprot id: S5TF72
names: Similarity
names: Subunit
messages: Belongs to the muconolactone Delta-isomerase family.
messages: Homodecamer.

1224163:B841 RS04150
gene id: 1224163:B841_RS04150
uniprot id: S5TH84
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1224163:B841 RS00940
gene id: 1224163:B841_RS00940
uniprot id: S5SZG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

1224163:B841 RS07460
gene id: 1224163:B841_RS07460
uniprot id: S5TJQ3
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1224163:B841 RS07950
gene id: 1224163:B841_RS07950
uniprot id: S5T347
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224163:B841 RS05655
gene id: 1224163:B841_RS05655
uniprot id: S5STW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1224163:B841 RS06515
gene id: 1224163:B841_RS06515
uniprot id: S5TIN6
names: Similarity
messages: Belongs to the UPF0434 family.

1224163:B841 RS00840
gene id: 1224163:B841_RS00840
uniprot id: S5SZE7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03110
gene id: 1224163:B841_RS03110
uniprot id: S5TGS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1224163:B841 RS12945
gene id: 1224163:B841_RS12945
uniprot id: S5TMY8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1224163:B841 RS00170
gene id: 1224163:B841_RS00170
uniprot id: S5SR20
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1224163:B841 RS08200
gene id: 1224163:B841_RS08200
uniprot id: S5T385
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1224163:B841 RS01150
gene id: 1224163:B841_RS01150
uniprot id: S5SRR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1224163:B841 RS06810
gene id: 1224163:B841_RS06810
uniprot id: S5SUF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1224163:B841 RS06925
gene id: 1224163:B841_RS06925
uniprot id: S5SUW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1224163:B841 RS02240
gene id: 1224163:B841_RS02240
uniprot id: S5TG79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1224163:B841 RS10945
gene id: 1224163:B841_RS10945
uniprot id: S5T4T1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS05245
gene id: 1224163:B841_RS05245
uniprot id: S5TI17
names: Similarity
messages: Belongs to the ArsC family.

1224163:B841 RS00430
gene id: 1224163:B841_RS00430
uniprot id: S5TF78
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1224163:B841 RS03905
gene id: 1224163:B841_RS03905
uniprot id: S5TH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1224163:B841 RS08060
gene id: 1224163:B841_RS08060
uniprot id: S5SVK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1224163:B841 RS10895
gene id: 1224163:B841_RS10895
uniprot id: S5SX05
names: Similarity
messages: Belongs to the fructosamine kinase family.

1224163:B841 RS06025
gene id: 1224163:B841_RS06025
uniprot id: S5SU28
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1224163:B841 RS06890
gene id: 1224163:B841_RS06890
uniprot id: S5T2J2
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

1224163:B841 RS12005
gene id: 1224163:B841_RS12005
uniprot id: S5TMB6
names: Subcellular Location Annotation
messages: Cytoplasm

1224163:B841 RS05845
gene id: 1224163:B841_RS05845
uniprot id: S5TIR4
names: Similarity
messages: Belongs to the UPF0045 family.

1224163:B841 RS13085
gene id: 1224163:B841_RS13085
uniprot id: S5T603
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

1224163:B841 RS14125
gene id: 1224163:B841_RS14125
uniprot id: S5T3K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS10490
gene id: 1224163:B841_RS10490
uniprot id: S5TL04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS12225
gene id: 1224163:B841_RS12225
uniprot id: S5SXL1
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1224163:B841 RS04715
gene id: 1224163:B841_RS04715
uniprot id: S5STM3
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1224163:B841 RS04600
gene id: 1224163:B841_RS04600
uniprot id: S5STA6
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1224163:B841 RS12115
gene id: 1224163:B841_RS12115
uniprot id: S5T5E2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1224163:B841 RS11700
gene id: 1224163:B841_RS11700
uniprot id: S5SXB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1224163:B841 RS07215
gene id: 1224163:B841_RS07215
uniprot id: S5SUM7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1224163:B841 RS13855
gene id: 1224163:B841_RS13855
uniprot id: S5SUS8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1224163:B841 RS08240
gene id: 1224163:B841_RS08240
uniprot id: S5TK40
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS07985
gene id: 1224163:B841_RS07985
uniprot id: S5SVI9
names: Similarity
messages: Belongs to the PspA/IM30 family.

1224163:B841 RS07980
gene id: 1224163:B841_RS07980
uniprot id: S5TJL6
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS00490
gene id: 1224163:B841_RS00490
uniprot id: S5TFZ3
names: Similarity
messages: Belongs to the cytochrome P450 family.

1224163:B841 RS07065
gene id: 1224163:B841_RS07065
uniprot id: S5SUK0
names: Subcellular Location Annotation
messages: Cell membrane

1224163:B841 RS03700
gene id: 1224163:B841_RS03700
uniprot id: S5THM7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1224163:B841 RS11090
gene id: 1224163:B841_RS11090
uniprot id: S5TL93
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

1224163:B841 RS01365
gene id: 1224163:B841_RS01365
uniprot id: S5SZQ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1224163:B841 RS05165
gene id: 1224163:B841_RS05165
uniprot id: S5T1S1
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS05370
gene id: 1224163:B841_RS05370
uniprot id: S5SU25
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224163:B841 RS11140
gene id: 1224163:B841_RS11140
uniprot id: S5TLA2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1224163:B841 RS05385
gene id: 1224163:B841_RS05385
uniprot id: S5T1V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1224163:B841 RS08360
gene id: 1224163:B841_RS08360
uniprot id: S5SVP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1224163:B841 RS02575
gene id: 1224163:B841_RS02575
uniprot id: S5SSB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1224163:B841 RS05230
gene id: 1224163:B841_RS05230
uniprot id: S5TII5
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11950
gene id: 1224163:B841_RS11950
uniprot id: S5SXF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS07150
gene id: 1224163:B841_RS07150
uniprot id: S5TJ39
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS03105
gene id: 1224163:B841_RS03105
uniprot id: S5T0M5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS01575
gene id: 1224163:B841_RS01575
uniprot id: S5SRY7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS12540
gene id: 1224163:B841_RS12540
uniprot id: S5SXS0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1224163:B841 RS00560
gene id: 1224163:B841_RS00560
uniprot id: S5SRH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224163:B841 RS07650
gene id: 1224163:B841_RS07650
uniprot id: S5SUX7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1224163:B841 RS02635
gene id: 1224163:B841_RS02635
uniprot id: S5TGI9
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02405
gene id: 1224163:B841_RS02405
uniprot id: S5T097
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1224163:B841 RS01505
gene id: 1224163:B841_RS01505
uniprot id: S5TGH1
names: Similarity
messages: Belongs to the catalase family.

1224163:B841 RS11360
gene id: 1224163:B841_RS11360
uniprot id: S5SWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS08380
gene id: 1224163:B841_RS08380
uniprot id: S5TJS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1224163:B841 RS06560
gene id: 1224163:B841_RS06560
uniprot id: S5TJ53
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1224163:B841 RS09325
gene id: 1224163:B841_RS09325
uniprot id: S5TK87
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1224163:B841 RS10045
gene id: 1224163:B841_RS10045
uniprot id: S5SWL3
names: Similarity
messages: Belongs to the FGGY kinase family.

1224163:B841 RS03005
gene id: 1224163:B841_RS03005
uniprot id: S5T0K6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1224163:B841 RS08490
gene id: 1224163:B841_RS08490
uniprot id: S5TK85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1224163:B841 RS11910
gene id: 1224163:B841_RS11910
uniprot id: S5SX49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1224163:B841 RS06045
gene id: 1224163:B841_RS06045
uniprot id: S5TIU7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11550
gene id: 1224163:B841_RS11550
uniprot id: S5SX95
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11865
gene id: 1224163:B841_RS11865
uniprot id: S5T593
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS06910
gene id: 1224163:B841_RS06910
uniprot id: S5SUH0
names: Similarity
messages: Belongs to the peptidase M18 family.

1224163:B841 RS04745
gene id: 1224163:B841_RS04745
uniprot id: S5TI75
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1224163:B841 RS12020
gene id: 1224163:B841_RS12020
uniprot id: S5TLU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1224163:B841 RS05190
gene id: 1224163:B841_RS05190
uniprot id: S5T1S4
names: Similarity
messages: Belongs to the TPP enzyme family.

1224163:B841 RS07285
gene id: 1224163:B841_RS07285
uniprot id: S5TJK5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS01595
gene id: 1224163:B841_RS01595
uniprot id: S5TFS5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1224163:B841 RS10335
gene id: 1224163:B841_RS10335
uniprot id: S5SWT7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1224163:B841 RS11780
gene id: 1224163:B841_RS11780
uniprot id: S5TM65
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1224163:B841 RS08670
gene id: 1224163:B841_RS08670
uniprot id: S5SVE3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1224163:B841 RS02660
gene id: 1224163:B841_RS02660
uniprot id: S5TGJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1224163:B841 RS05675
gene id: 1224163:B841_RS05675
uniprot id: S5STW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1224163:B841 RS07095
gene id: 1224163:B841_RS07095
uniprot id: S5T2M8
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1224163:B841 RS05070
gene id: 1224163:B841_RS05070
uniprot id: S5TIF5
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

1224163:B841 RS06080
gene id: 1224163:B841_RS06080
uniprot id: S5T258
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS10235
gene id: 1224163:B841_RS10235
uniprot id: S5TKW4
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1224163:B841 RS07300
gene id: 1224163:B841_RS07300
uniprot id: S5TJ73
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1224163:B841 RS04240
gene id: 1224163:B841_RS04240
uniprot id: S5THX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1224163:B841 RS12500
gene id: 1224163:B841_RS12500
uniprot id: S5SXF5
names: Similarity
messages: Belongs to the PspA/IM30 family.

1224163:B841 RS11795
gene id: 1224163:B841_RS11795
uniprot id: S5TLN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1224163:B841 RS07305
gene id: 1224163:B841_RS07305
uniprot id: S5SV49
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1224163:B841 RS03515
gene id: 1224163:B841_RS03515
uniprot id: S5ST00
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1224163:B841 RS11315
gene id: 1224163:B841_RS11315
uniprot id: S5T4Z2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS07540
gene id: 1224163:B841_RS07540
uniprot id: S5SUU9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1224163:B841 RS08605
gene id: 1224163:B841_RS08605
uniprot id: S5TJV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS12610
gene id: 1224163:B841_RS12610
uniprot id: S5TMA3
names: Similarity
messages: Belongs to the FPG family.

1224163:B841 RS10635
gene id: 1224163:B841_RS10635
uniprot id: S5SWI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1224163:B841 RS12670
gene id: 1224163:B841_RS12670
uniprot id: S5TMR4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224163:B841 RS00050
gene id: 1224163:B841_RS00050
uniprot id: S5TFS4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1224163:B841 RS10270
gene id: 1224163:B841_RS10270
uniprot id: S5TLF0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224163:B841 RS11465
gene id: 1224163:B841_RS11465
uniprot id: S5T515
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1224163:B841 RS08590
gene id: 1224163:B841_RS08590
uniprot id: S5TKB9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS09105
gene id: 1224163:B841_RS09105
uniprot id: S5SW15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1224163:B841 RS08860
gene id: 1224163:B841_RS08860
uniprot id: S5TKJ7
names: Similarity
messages: Belongs to the YggT family.

1224163:B841 RS09865
gene id: 1224163:B841_RS09865
uniprot id: S5TKL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1224163:B841 RS03380
gene id: 1224163:B841_RS03380
uniprot id: S5T0S3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1224163:B841 RS02605
gene id: 1224163:B841_RS02605
uniprot id: S5T0F1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1224163:B841 RS03595
gene id: 1224163:B841_RS03595
uniprot id: S5THK9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224163:B841 RS08600
gene id: 1224163:B841_RS08600
uniprot id: S5T3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS02295
gene id: 1224163:B841_RS02295
uniprot id: S5SSD5
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1224163:B841 RS07925
gene id: 1224163:B841_RS07925
uniprot id: S5T344
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1224163:B841 RS10830
gene id: 1224163:B841_RS10830
uniprot id: S5SWL2
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1224163:B841 RS02170
gene id: 1224163:B841_RS02170
uniprot id: S5SSA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS02900
gene id: 1224163:B841_RS02900
uniprot id: S5SSF8
names: Similarity
messages: Belongs to the cytochrome P450 family.

1224163:B841 RS06445
gene id: 1224163:B841_RS06445
uniprot id: S5SUL6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224163:B841 RS08445
gene id: 1224163:B841_RS08445
uniprot id: S5SVA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224163:B841 RS01995
gene id: 1224163:B841_RS01995
uniprot id: S5T027
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224163:B841 RS08405
gene id: 1224163:B841_RS08405
uniprot id: S5TJS7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1224163:B841 RS09515
gene id: 1224163:B841_RS09515
uniprot id: S5TKW8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1224163:B841 RS03185
gene id: 1224163:B841_RS03185
uniprot id: S5T0N9
names: Similarity
messages: Belongs to the peptidase C40 family.

1224163:B841 RS02720
gene id: 1224163:B841_RS02720
uniprot id: S5TH71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1224163:B841 RS04430
gene id: 1224163:B841_RS04430
uniprot id: S5ST78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1224163:B841 RS04640
gene id: 1224163:B841_RS04640
uniprot id: S5STK9
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS11400
gene id: 1224163:B841_RS11400
uniprot id: S5SX72
names: Similarity
messages: Belongs to the alkaline phosphatase family.

1224163:B841 RS10700
gene id: 1224163:B841_RS10700
uniprot id: S5T4P5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1224163:B841 RS07725
gene id: 1224163:B841_RS07725
uniprot id: S5T321
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1224163:B841 RS06140
gene id: 1224163:B841_RS06140
uniprot id: S5SUH1
names: Similarity
messages: Belongs to the isochorismate synthase family.

1224163:B841 RS03080
gene id: 1224163:B841_RS03080
uniprot id: S5T0M2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1224163:B841 RS12805
gene id: 1224163:B841_RS12805
uniprot id: S5SXN8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224163:B841 RS06005
gene id: 1224163:B841_RS06005
uniprot id: S5T244
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS09715
gene id: 1224163:B841_RS09715
uniprot id: S5TKH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1224163:B841 RS08800
gene id: 1224163:B841_RS08800
uniprot id: S5TJZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1224163:B841 RS08740
gene id: 1224163:B841_RS08740
uniprot id: S5SVF5
names: Similarity
messages: Belongs to the IMPACT family.

1224163:B841 RS02645
gene id: 1224163:B841_RS02645
uniprot id: S5TH61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1224163:B841 RS08910
gene id: 1224163:B841_RS08910
uniprot id: S5TKK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1224163:B841 RS04580
gene id: 1224163:B841_RS04580
uniprot id: S5T1E6
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1224163:B841 RS02835
gene id: 1224163:B841_RS02835
uniprot id: S5TGM1
names: Similarity
messages: Belongs to the WXG100 family.

1224163:B841 RS02410
gene id: 1224163:B841_RS02410
uniprot id: S5SSF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1224163:B841 RS10020
gene id: 1224163:B841_RS10020
uniprot id: S5SWK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Belongs to the sulfur carrier protein TusA family.
messages: Membrane

1224163:B841 RS11415
gene id: 1224163:B841_RS11415
uniprot id: S5T506
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS08730
gene id: 1224163:B841_RS08730
uniprot id: S5SVV3
names: Similarity
messages: Belongs to the HSP15 family.

1224163:B841 RS08745
gene id: 1224163:B841_RS08745
uniprot id: S5T3H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1224163:B841 RS04030
gene id: 1224163:B841_RS04030
uniprot id: S5ST88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1224163:B841 RS02210
gene id: 1224163:B841_RS02210
uniprot id: S5T067
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS12260
gene id: 1224163:B841_RS12260
uniprot id: S5SXB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1224163:B841 RS05350
gene id: 1224163:B841_RS05350
uniprot id: S5TIJ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1224163:B841 RS08940
gene id: 1224163:B841_RS08940
uniprot id: S5SVJ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1224163:B841 RS12215
gene id: 1224163:B841_RS12215
uniprot id: S5T5G0
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1224163:B841 RS11305
gene id: 1224163:B841_RS11305
uniprot id: S5TLX1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1224163:B841 RS02850
gene id: 1224163:B841_RS02850
uniprot id: S5SSF2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1224163:B841 RS06235
gene id: 1224163:B841_RS06235
uniprot id: S5TIH8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1224163:B841 RS01670
gene id: 1224163:B841_RS01670
uniprot id: S5TFT9
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS00495
gene id: 1224163:B841_RS00495
uniprot id: S5SR69
names: Similarity
messages: Belongs to the cytochrome P450 family.

1224163:B841 RS08290
gene id: 1224163:B841_RS08290
uniprot id: S5TK46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1224163:B841 RS13260
gene id: 1224163:B841_RS13260
uniprot id: S5TGT6
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS01015
gene id: 1224163:B841_RS01015
uniprot id: S5SZI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS01175
gene id: 1224163:B841_RS01175
uniprot id: S5TGB6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224163:B841 RS04500
gene id: 1224163:B841_RS04500
uniprot id: S5STI4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1224163:B841 RS00970
gene id: 1224163:B841_RS00970
uniprot id: S5TFH6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224163:B841 RS03990
gene id: 1224163:B841_RS03990
uniprot id: S5SSY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS10785
gene id: 1224163:B841_RS10785
uniprot id: S5T4Q8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1224163:B841 RS08140
gene id: 1224163:B841_RS08140
uniprot id: S5TK24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS01940
gene id: 1224163:B841_RS01940
uniprot id: S5SRW5
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS06505
gene id: 1224163:B841_RS06505
uniprot id: S5SU97
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS08915
gene id: 1224163:B841_RS08915
uniprot id: S5SVJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1224163:B841 RS01840
gene id: 1224163:B841_RS01840
uniprot id: S5SRU5
names: Similarity
messages: Belongs to the peptidase M1 family.

1224163:B841 RS06110
gene id: 1224163:B841_RS06110
uniprot id: S5TIG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS06365
gene id: 1224163:B841_RS06365
uniprot id: S5TIK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1224163:B841 RS12705
gene id: 1224163:B841_RS12705
uniprot id: S5T5S4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS12520
gene id: 1224163:B841_RS12520
uniprot id: S5TMM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224163:B841 RS05260
gene id: 1224163:B841_RS05260
uniprot id: S5STP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1224163:B841 RS11755
gene id: 1224163:B841_RS11755
uniprot id: S5TM59
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1224163:B841 RS00395
gene id: 1224163:B841_RS00395
uniprot id: S5SR54
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS05805
gene id: 1224163:B841_RS05805
uniprot id: S5T210
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1224163:B841 RS00315
gene id: 1224163:B841_RS00315
uniprot id: S5TFW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224163:B841 RS07340
gene id: 1224163:B841_RS07340
uniprot id: S5SUQ1
names: Similarity
messages: Belongs to the peptidase M24B family.

1224163:B841 RS04335
gene id: 1224163:B841_RS04335
uniprot id: S5STE8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS03085
gene id: 1224163:B841_RS03085
uniprot id: S5TGS3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1224163:B841 RS02655
gene id: 1224163:B841_RS02655
uniprot id: S5T0F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1224163:B841 RS10245
gene id: 1224163:B841_RS10245
uniprot id: S5TLE6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224163:B841 RS05890
gene id: 1224163:B841_RS05890
uniprot id: S5SUC5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1224163:B841 RS08750
gene id: 1224163:B841_RS08750
uniprot id: S5TJY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1224163:B841 RS01500
gene id: 1224163:B841_RS01500
uniprot id: S5SRX4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224163:B841 RS06450
gene id: 1224163:B841_RS06450
uniprot id: S5TJ30
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224163:B841 RS01255
gene id: 1224163:B841_RS01255
uniprot id: S5TGD1
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

1224163:B841 RS09020
gene id: 1224163:B841_RS09020
uniprot id: S5T3N2
names: Similarity
messages: Belongs to the peptidase C40 family.

1224163:B841 RS11775
gene id: 1224163:B841_RS11775
uniprot id: S5SXC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1224163:B841 RS07170
gene id: 1224163:B841_RS07170
uniprot id: S5T2P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1224163:B841 RS03510
gene id: 1224163:B841_RS03510
uniprot id: S5TGY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1224163:B841 RS00590
gene id: 1224163:B841_RS00590
uniprot id: S5TG07
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1224163:B841 RS07290
gene id: 1224163:B841_RS07290
uniprot id: S5SUP1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1224163:B841 RS07970
gene id: 1224163:B841_RS07970
uniprot id: S5SV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1224163:B841 RS08040
gene id: 1224163:B841_RS08040
uniprot id: S5TK13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1224163:B841 RS08005
gene id: 1224163:B841_RS08005
uniprot id: S5TJL9
names: Similarity
messages: Belongs to the YciI family.

1224163:B841 RS11860
gene id: 1224163:B841_RS11860
uniprot id: S5SX40
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS08480
gene id: 1224163:B841_RS08480
uniprot id: S5TJT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS03720
gene id: 1224163:B841_RS03720
uniprot id: S5ST35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1224163:B841 RS07810
gene id: 1224163:B841_RS07810
uniprot id: S5SVG5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1224163:B841 RS06410
gene id: 1224163:B841_RS06410
uniprot id: S5T2B4
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS03860
gene id: 1224163:B841_RS03860
uniprot id: S5ST52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1224163:B841 RS12410
gene id: 1224163:B841_RS12410
uniprot id: S5SXE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1224163:B841 RS12015
gene id: 1224163:B841_RS12015
uniprot id: S5T5C6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1224163:B841 RS12130
gene id: 1224163:B841_RS12130
uniprot id: S5TME1
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS10165
gene id: 1224163:B841_RS10165
uniprot id: S5SWQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1224163:B841 RS03985
gene id: 1224163:B841_RS03985
uniprot id: S5THT4
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1224163:B841 RS09710
gene id: 1224163:B841_RS09710
uniprot id: S5T413
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224163:B841 RS04180
gene id: 1224163:B841_RS04180
uniprot id: S5TH90
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS08430
gene id: 1224163:B841_RS08430
uniprot id: S5TJT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1224163:B841 RS08985
gene id: 1224163:B841_RS08985
uniprot id: S5TKM3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

1224163:B841 RS06510
gene id: 1224163:B841_RS06510
uniprot id: S5T2D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1224163:B841 RS08635
gene id: 1224163:B841_RS08635
uniprot id: S5SVT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1224163:B841 RS00015
gene id: 1224163:B841_RS00015
uniprot id: S5TF13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1224163:B841 RS08345
gene id: 1224163:B841_RS08345
uniprot id: S5SV93
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224163:B841 RS05695
gene id: 1224163:B841_RS05695
uniprot id: S5TIP7
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS09055
gene id: 1224163:B841_RS09055
uniprot id: S5SW06
names: Similarity
messages: Belongs to the asparagine synthetase family.

1224163:B841 RS09510
gene id: 1224163:B841_RS09510
uniprot id: S5SW88
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

1224163:B841 RS02150
gene id: 1224163:B841_RS02150
uniprot id: S5TGV6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1224163:B841 RS12415
gene id: 1224163:B841_RS12415
uniprot id: S5T5K7
names: Similarity
messages: Belongs to the universal stress protein A family.

1224163:B841 RS01615
gene id: 1224163:B841_RS01615
uniprot id: S5SZV1
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS09885
gene id: 1224163:B841_RS09885
uniprot id: S5T458
names: Subcellular Location Annotation
messages: Membrane

1224163:B841 RS02675
gene id: 1224163:B841_RS02675
uniprot id: S5SSD0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1224163:B841 RS11285
gene id: 1224163:B841_RS11285
uniprot id: S5SWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane