1201294:BN140 RS10160
gene id: 1201294:BN140_RS10160
uniprot id: I7JA57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1201294:BN140 RS02925
gene id: 1201294:BN140_RS02925
uniprot id: I7KBM6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1201294:BN140 RS04450
gene id: 1201294:BN140_RS04450
uniprot id: I7J805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1201294:BN140 RS11635
gene id: 1201294:BN140_RS11635
uniprot id: I7KDX0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1201294:BN140 RS02275
gene id: 1201294:BN140_RS02275
uniprot id: I7KBE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS03670
gene id: 1201294:BN140_RS03670
uniprot id: I7KYC8
names: Similarity
messages: Belongs to the glutaredoxin family.

1201294:BN140 RS08610
gene id: 1201294:BN140_RS08610
uniprot id: I7KDA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

1201294:BN140 RS02315
gene id: 1201294:BN140_RS02315
uniprot id: I7LLI1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1201294:BN140 RS01500
gene id: 1201294:BN140_RS01500
uniprot id: I7J7A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1201294:BN140 RS02530
gene id: 1201294:BN140_RS02530
uniprot id: I7KBH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1201294:BN140 RS04010
gene id: 1201294:BN140_RS04010
uniprot id: I7KBX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1201294:BN140 RS11285
gene id: 1201294:BN140_RS11285
uniprot id: I7L114
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1201294:BN140 RS03950
gene id: 1201294:BN140_RS03950
uniprot id: I7LLW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1201294:BN140 RS02720
gene id: 1201294:BN140_RS02720
uniprot id: I7LLM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1201294:BN140 RS04360
gene id: 1201294:BN140_RS04360
uniprot id: I7KC16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS02910
gene id: 1201294:BN140_RS02910
uniprot id: I7J7L7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1201294:BN140 RS09360
gene id: 1201294:BN140_RS09360
uniprot id: I7KDG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1201294:BN140 RS03930
gene id: 1201294:BN140_RS03930
uniprot id: I7KYF2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1201294:BN140 RS05800
gene id: 1201294:BN140_RS05800
uniprot id: I7LJL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1201294:BN140 RS07215
gene id: 1201294:BN140_RS07215
uniprot id: I7LJV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1201294:BN140 RS11810
gene id: 1201294:BN140_RS11810
uniprot id: I7LKT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1201294:BN140 RS01020
gene id: 1201294:BN140_RS01020
uniprot id: I7J768
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1201294:BN140 RS02950
gene id: 1201294:BN140_RS02950
uniprot id: I7KY54
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1201294:BN140 RS12745
gene id: 1201294:BN140_RS12745
uniprot id: I7LNY1
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1201294:BN140 RS06750
gene id: 1201294:BN140_RS06750
uniprot id: I7J8R7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS05745
gene id: 1201294:BN140_RS05745
uniprot id: I7KCK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1201294:BN140 RS07545
gene id: 1201294:BN140_RS07545
uniprot id: I7LMP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1201294:BN140 RS05975
gene id: 1201294:BN140_RS05975
uniprot id: I7J8J2
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08445
gene id: 1201294:BN140_RS08445
uniprot id: I7LMX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1201294:BN140 RS08705
gene id: 1201294:BN140_RS08705
uniprot id: I7L047
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1201294:BN140 RS06055
gene id: 1201294:BN140_RS06055
uniprot id: I7KZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1201294:BN140 RS05925
gene id: 1201294:BN140_RS05925
uniprot id: I7J8I8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1201294:BN140 RS00600
gene id: 1201294:BN140_RS00600
uniprot id: I7J740
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS01325
gene id: 1201294:BN140_RS01325
uniprot id: I7KB24
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS02670
gene id: 1201294:BN140_RS02670
uniprot id: I7LLL5
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

1201294:BN140 RS01900
gene id: 1201294:BN140_RS01900
uniprot id: I7KB90
names: Similarity
messages: Belongs to the peptidase C56 family.

1201294:BN140 RS03600
gene id: 1201294:BN140_RS03600
uniprot id: I7KYC2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1201294:BN140 RS01540
gene id: 1201294:BN140_RS01540
uniprot id: I7KB50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1201294:BN140 RS00330
gene id: 1201294:BN140_RS00330
uniprot id: I7J721
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS10295
gene id: 1201294:BN140_RS10295
uniprot id: I7KDL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1201294:BN140 RS08490
gene id: 1201294:BN140_RS08490
uniprot id: I7J9G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1201294:BN140 RS07065
gene id: 1201294:BN140_RS07065
uniprot id: I7J8W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1201294:BN140 RS01760
gene id: 1201294:BN140_RS01760
uniprot id: I7KXN9
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1201294:BN140 RS05990
gene id: 1201294:BN140_RS05990
uniprot id: I7LJM5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1201294:BN140 RS07090
gene id: 1201294:BN140_RS07090
uniprot id: I7J8W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1201294:BN140 RS05635
gene id: 1201294:BN140_RS05635
uniprot id: I7J8F4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

1201294:BN140 RS12165
gene id: 1201294:BN140_RS12165
uniprot id: I7KE12
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS04515
gene id: 1201294:BN140_RS04515
uniprot id: I7KC34
names: Similarity
messages: Belongs to the class-I fumarase family.

1201294:BN140 RS04915
gene id: 1201294:BN140_RS04915
uniprot id: I7J849
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1201294:BN140 RS11350
gene id: 1201294:BN140_RS11350
uniprot id: I7JAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1201294:BN140 RS05840
gene id: 1201294:BN140_RS05840
uniprot id: I7LJL6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1201294:BN140 RS01445
gene id: 1201294:BN140_RS01445
uniprot id: I7LIQ8
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS01940
gene id: 1201294:BN140_RS01940
uniprot id: I7KXR6
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS01805
gene id: 1201294:BN140_RS01805
uniprot id: I7LLE0
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS13005
gene id: 1201294:BN140_RS13005
uniprot id: I7LP00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1201294:BN140 RS12330
gene id: 1201294:BN140_RS12330
uniprot id: I7L1F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1201294:BN140 RS09745
gene id: 1201294:BN140_RS09745
uniprot id: I7L0H9
names: Similarity
messages: Belongs to the archease family.

1201294:BN140 RS07660
gene id: 1201294:BN140_RS07660
uniprot id: I7J967
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS02325
gene id: 1201294:BN140_RS02325
uniprot id: I7KBE7
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1201294:BN140 RS00425
gene id: 1201294:BN140_RS00425
uniprot id: I7LL28
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1201294:BN140 RS06870
gene id: 1201294:BN140_RS06870
uniprot id: I7J8T2
names: Similarity
messages: Belongs to the FrhG family.

1201294:BN140 RS03785
gene id: 1201294:BN140_RS03785
uniprot id: I7KYD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1201294:BN140 RS08455
gene id: 1201294:BN140_RS08455
uniprot id: I7KD96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS07470
gene id: 1201294:BN140_RS07470
uniprot id: I7LMN8
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS01455
gene id: 1201294:BN140_RS01455
uniprot id: I7LLB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1201294:BN140 RS01575
gene id: 1201294:BN140_RS01575
uniprot id: I7LIR6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1201294:BN140 RS00830
gene id: 1201294:BN140_RS00830
uniprot id: I7LL61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

1201294:BN140 RS08855
gene id: 1201294:BN140_RS08855
uniprot id: I7L066
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

1201294:BN140 RS07025
gene id: 1201294:BN140_RS07025
uniprot id: I7KZK4
names: Similarity
messages: Belongs to the HAM1 NTPase family.

1201294:BN140 RS07825
gene id: 1201294:BN140_RS07825
uniprot id: I7LK08
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1201294:BN140 RS04180
gene id: 1201294:BN140_RS04180
uniprot id: I7KYI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

1201294:BN140 RS08230
gene id: 1201294:BN140_RS08230
uniprot id: I7LMW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1201294:BN140 RS00690
gene id: 1201294:BN140_RS00690
uniprot id: I7J746
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1201294:BN140 RS01520
gene id: 1201294:BN140_RS01520
uniprot id: I7LIR3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1201294:BN140 RS12390
gene id: 1201294:BN140_RS12390
uniprot id: I7JAX4
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1201294:BN140 RS04370
gene id: 1201294:BN140_RS04370
uniprot id: I7J7Z6
names: Similarity
messages: Belongs to the DtxR/MntR family.

1201294:BN140 RS01735
gene id: 1201294:BN140_RS01735
uniprot id: I7KXN4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS01885
gene id: 1201294:BN140_RS01885
uniprot id: I7J7D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1201294:BN140 RS11600
gene id: 1201294:BN140_RS11600
uniprot id: I7LNN8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS11575
gene id: 1201294:BN140_RS11575
uniprot id: I7LNN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1201294:BN140 RS01835
gene id: 1201294:BN140_RS01835
uniprot id: I7KXQ0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1201294:BN140 RS08520
gene id: 1201294:BN140_RS08520
uniprot id: I7LMY5
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1201294:BN140 RS10180
gene id: 1201294:BN140_RS10180
uniprot id: I7JA62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1201294:BN140 RS04460
gene id: 1201294:BN140_RS04460
uniprot id: I7KYM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1201294:BN140 RS05760
gene id: 1201294:BN140_RS05760
uniprot id: I7LMA7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS00060
gene id: 1201294:BN140_RS00060
uniprot id: I7KAM9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1201294:BN140 RS05750
gene id: 1201294:BN140_RS05750
uniprot id: I7LJL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

1201294:BN140 RS03955
gene id: 1201294:BN140_RS03955
uniprot id: I7KYF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1201294:BN140 RS03430
gene id: 1201294:BN140_RS03430
uniprot id: I7KBS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1201294:BN140 RS09145
gene id: 1201294:BN140_RS09145
uniprot id: I7LN33
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

1201294:BN140 RS08985
gene id: 1201294:BN140_RS08985
uniprot id: I7LK83
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1201294:BN140 RS11540
gene id: 1201294:BN140_RS11540
uniprot id: I7JAN2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1201294:BN140 RS04215
gene id: 1201294:BN140_RS04215
uniprot id: I7LJ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

1201294:BN140 RS03865
gene id: 1201294:BN140_RS03865
uniprot id: I7J7U1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1201294:BN140 RS12275
gene id: 1201294:BN140_RS12275
uniprot id: I7LNT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS06790
gene id: 1201294:BN140_RS06790
uniprot id: I7KCV5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

1201294:BN140 RS08760
gene id: 1201294:BN140_RS08760
uniprot id: I7KDB8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS08495
gene id: 1201294:BN140_RS08495
uniprot id: I7LMY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1201294:BN140 RS05570
gene id: 1201294:BN140_RS05570
uniprot id: I7LM91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1201294:BN140 RS06835
gene id: 1201294:BN140_RS06835
uniprot id: I7LJS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1201294:BN140 RS02700
gene id: 1201294:BN140_RS02700
uniprot id: I7KY33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

1201294:BN140 RS12055
gene id: 1201294:BN140_RS12055
uniprot id: I7JAT9
names: Similarity
messages: Belongs to the UPF0237 family.

1201294:BN140 RS08585
gene id: 1201294:BN140_RS08585
uniprot id: I7KDA5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1201294:BN140 RS05710
gene id: 1201294:BN140_RS05710
uniprot id: I7J8G2
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

1201294:BN140 RS03435
gene id: 1201294:BN140_RS03435
uniprot id: I7LJ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS08035
gene id: 1201294:BN140_RS08035
uniprot id: I7J9B4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05335
gene id: 1201294:BN140_RS05335
uniprot id: I7KCF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1201294:BN140 RS00945
gene id: 1201294:BN140_RS00945
uniprot id: I7LL69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1201294:BN140 RS09630
gene id: 1201294:BN140_RS09630
uniprot id: I7J9V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS00920
gene id: 1201294:BN140_RS00920
uniprot id: I7LL67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1201294:BN140 RS07535
gene id: 1201294:BN140_RS07535
uniprot id: I7LJX9
names: Similarity
messages: Belongs to the TrpC family.

1201294:BN140 RS07420
gene id: 1201294:BN140_RS07420
uniprot id: I7LMN6
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05030
gene id: 1201294:BN140_RS05030
uniprot id: I7KYV2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS11985
gene id: 1201294:BN140_RS11985
uniprot id: I7LNR7
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS04355
gene id: 1201294:BN140_RS04355
uniprot id: I7KYL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

1201294:BN140 RS12785
gene id: 1201294:BN140_RS12785
uniprot id: I7LL04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

1201294:BN140 RS08175
gene id: 1201294:BN140_RS08175
uniprot id: I7LMV7
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08395
gene id: 1201294:BN140_RS08395
uniprot id: I7LMX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1201294:BN140 RS05960
gene id: 1201294:BN140_RS05960
uniprot id: I7KZ71
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS07210
gene id: 1201294:BN140_RS07210
uniprot id: W6Q8R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1201294:BN140 RS11150
gene id: 1201294:BN140_RS11150
uniprot id: I7KDT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS02885
gene id: 1201294:BN140_RS02885
uniprot id: I7KY49
names: Similarity
messages: Belongs to the MEMO1 family.

1201294:BN140 RS12885
gene id: 1201294:BN140_RS12885
uniprot id: I7LL09
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1201294:BN140 RS01705
gene id: 1201294:BN140_RS01705
uniprot id: I7KXN1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1201294:BN140 RS10885
gene id: 1201294:BN140_RS10885
uniprot id: I7LNI2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1201294:BN140 RS10695
gene id: 1201294:BN140_RS10695
uniprot id: I7L0V5
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS03860
gene id: 1201294:BN140_RS03860
uniprot id: I7LJ70
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1201294:BN140 RS02625
gene id: 1201294:BN140_RS02625
uniprot id: I7KY19
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1201294:BN140 RS09380
gene id: 1201294:BN140_RS09380
uniprot id: I7L0D4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS08310
gene id: 1201294:BN140_RS08310
uniprot id: I7J9E7
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

1201294:BN140 RS04840
gene id: 1201294:BN140_RS04840
uniprot id: I7LM30
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1201294:BN140 RS04135
gene id: 1201294:BN140_RS04135
uniprot id: I7KBZ3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1201294:BN140 RS05050
gene id: 1201294:BN140_RS05050
uniprot id: I7KYV5
names: Similarity
messages: Belongs to the serpin family.

1201294:BN140 RS01395
gene id: 1201294:BN140_RS01395
uniprot id: I7LIQ4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1201294:BN140 RS01380
gene id: 1201294:BN140_RS01380
uniprot id: I7LLA6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1201294:BN140 RS01680
gene id: 1201294:BN140_RS01680
uniprot id: W6PPJ9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1201294:BN140 RS09660
gene id: 1201294:BN140_RS09660
uniprot id: I7LN73
names: Similarity
messages: Belongs to the GARS family.

1201294:BN140 RS09535
gene id: 1201294:BN140_RS09535
uniprot id: I7L0F3
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS12705
gene id: 1201294:BN140_RS12705
uniprot id: I7KE57
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS04965
gene id: 1201294:BN140_RS04965
uniprot id: I7LJE8
names: Similarity
messages: Belongs to the MCM family.

1201294:BN140 RS07585
gene id: 1201294:BN140_RS07585
uniprot id: I7J933
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

1201294:BN140 RS04480
gene id: 1201294:BN140_RS04480
uniprot id: I7LM03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1201294:BN140 RS10830
gene id: 1201294:BN140_RS10830
uniprot id: I7LKL7
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1201294:BN140 RS03510
gene id: 1201294:BN140_RS03510
uniprot id: I7LJ45
names: Similarity
messages: Belongs to the UPF0285 family.

1201294:BN140 RS01130
gene id: 1201294:BN140_RS01130
uniprot id: I7KXG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1201294:BN140 RS12145
gene id: 1201294:BN140_RS12145
uniprot id: I7LKW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1201294:BN140 RS00975
gene id: 1201294:BN140_RS00975
uniprot id: I7KXF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1201294:BN140 RS02515
gene id: 1201294:BN140_RS02515
uniprot id: I7J7I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS03550
gene id: 1201294:BN140_RS03550
uniprot id: I7KYB7
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

1201294:BN140 RS08880
gene id: 1201294:BN140_RS08880
uniprot id: I7L069
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08380
gene id: 1201294:BN140_RS08380
uniprot id: I7KD91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1201294:BN140 RS07270
gene id: 1201294:BN140_RS07270
uniprot id: I7J8Z3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS04585
gene id: 1201294:BN140_RS04585
uniprot id: I7LM11
names: Similarity
messages: Belongs to the UPF0212 family.

1201294:BN140 RS09390
gene id: 1201294:BN140_RS09390
uniprot id: I7LKA9
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1201294:BN140 RS01340
gene id: 1201294:BN140_RS01340
uniprot id: I7J790
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1201294:BN140 RS02150
gene id: 1201294:BN140_RS02150
uniprot id: I7KXU2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS01650
gene id: 1201294:BN140_RS01650
uniprot id: I7J7B7
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS03420
gene id: 1201294:BN140_RS03420
uniprot id: I7LLS3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1201294:BN140 RS04330
gene id: 1201294:BN140_RS04330
uniprot id: I7KYK8
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS04510
gene id: 1201294:BN140_RS04510
uniprot id: I7KYN2
names: Similarity
messages: Belongs to the class-I fumarase family.

1201294:BN140 RS11115
gene id: 1201294:BN140_RS11115
uniprot id: I7LNK0
names: Similarity
messages: Belongs to the peptidase S1C family.

1201294:BN140 RS02415
gene id: 1201294:BN140_RS02415
uniprot id: I7KXX9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1201294:BN140 RS04745
gene id: 1201294:BN140_RS04745
uniprot id: I7KYR4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS11485
gene id: 1201294:BN140_RS11485
uniprot id: I7KDV8
names: Similarity
messages: Belongs to the HupF/HypC family.

1201294:BN140 RS03780
gene id: 1201294:BN140_RS03780
uniprot id: I7LLU9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1201294:BN140 RS13320
gene id: 1201294:BN140_RS13320
uniprot id: I7LLV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1201294:BN140 RS04390
gene id: 1201294:BN140_RS04390
uniprot id: I7LJA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1201294:BN140 RS08505
gene id: 1201294:BN140_RS08505
uniprot id: I7KD99
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05860
gene id: 1201294:BN140_RS05860
uniprot id: I7KCL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS04090
gene id: 1201294:BN140_RS04090
uniprot id: I7LJ86
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1201294:BN140 RS08540
gene id: 1201294:BN140_RS08540
uniprot id: I7J9H3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1201294:BN140 RS07595
gene id: 1201294:BN140_RS07595
uniprot id: I7KZS5
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1201294:BN140 RS07035
gene id: 1201294:BN140_RS07035
uniprot id: I7LJU1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS08695
gene id: 1201294:BN140_RS08695
uniprot id: I7J9J2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1201294:BN140 RS08820
gene id: 1201294:BN140_RS08820
uniprot id: I7LK71
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

1201294:BN140 RS02705
gene id: 1201294:BN140_RS02705
uniprot id: I7KBK8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1201294:BN140 RS00775
gene id: 1201294:BN140_RS00775
uniprot id: I7J752
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1201294:BN140 RS06310
gene id: 1201294:BN140_RS06310
uniprot id: I7LMF1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1201294:BN140 RS07070
gene id: 1201294:BN140_RS07070
uniprot id: I7LML2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1201294:BN140 RS11015
gene id: 1201294:BN140_RS11015
uniprot id: I7L0Y1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1201294:BN140 RS02125
gene id: 1201294:BN140_RS02125
uniprot id: I7KXT9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1201294:BN140 RS06795
gene id: 1201294:BN140_RS06795
uniprot id: I7LJS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS00855
gene id: 1201294:BN140_RS00855
uniprot id: I7LL63
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1201294:BN140 RS09315
gene id: 1201294:BN140_RS09315
uniprot id: I7J9R5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1201294:BN140 RS05595
gene id: 1201294:BN140_RS05595
uniprot id: I7KZ34
names: Similarity
messages: Belongs to the acylphosphatase family.

1201294:BN140 RS10145
gene id: 1201294:BN140_RS10145
uniprot id: I7L0Q4
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1201294:BN140 RS07430
gene id: 1201294:BN140_RS07430
uniprot id: I7KD08
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1201294:BN140 RS08000
gene id: 1201294:BN140_RS08000
uniprot id: I7KZY4
names: Similarity
messages: Belongs to the AAA ATPase family.

1201294:BN140 RS00275
gene id: 1201294:BN140_RS00275
uniprot id: I7J717
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

1201294:BN140 RS04310
gene id: 1201294:BN140_RS04310
uniprot id: I7LJA3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1201294:BN140 RS00935
gene id: 1201294:BN140_RS00935
uniprot id: I7LIM2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

1201294:BN140 RS07690
gene id: 1201294:BN140_RS07690
uniprot id: I7LMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1201294:BN140 RS09670
gene id: 1201294:BN140_RS09670
uniprot id: I7KDI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1201294:BN140 RS07605
gene id: 1201294:BN140_RS07605
uniprot id: I7LJY5
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1201294:BN140 RS09275
gene id: 1201294:BN140_RS09275
uniprot id: W6PPN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1201294:BN140 RS08465
gene id: 1201294:BN140_RS08465
uniprot id: I7J9G5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1201294:BN140 RS06575
gene id: 1201294:BN140_RS06575
uniprot id: I7KCT1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1201294:BN140 RS00750
gene id: 1201294:BN140_RS00750
uniprot id: I7J750
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1201294:BN140 RS12225
gene id: 1201294:BN140_RS12225
uniprot id: I7JAV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1201294:BN140 RS04075
gene id: 1201294:BN140_RS04075
uniprot id: I7LLX2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1201294:BN140 RS07895
gene id: 1201294:BN140_RS07895
uniprot id: I7KZX3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1201294:BN140 RS00575
gene id: 1201294:BN140_RS00575
uniprot id: I7J738
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1201294:BN140 RS02825
gene id: 1201294:BN140_RS02825
uniprot id: I7J7L1
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05305
gene id: 1201294:BN140_RS05305
uniprot id: I7LM71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS04430
gene id: 1201294:BN140_RS04430
uniprot id: I7LM00
names: Similarity
messages: Belongs to the UPF0146 family.

1201294:BN140 RS09655
gene id: 1201294:BN140_RS09655
uniprot id: I7J9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1201294:BN140 RS10925
gene id: 1201294:BN140_RS10925
uniprot id: I7JAG0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1201294:BN140 RS06785
gene id: 1201294:BN140_RS06785
uniprot id: I7KZH4
names: Similarity
messages: Belongs to the LarC family.

1201294:BN140 RS06595
gene id: 1201294:BN140_RS06595
uniprot id: I7KZE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1201294:BN140 RS04230
gene id: 1201294:BN140_RS04230
uniprot id: I7LJ98
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

1201294:BN140 RS08390
gene id: 1201294:BN140_RS08390
uniprot id: I7J9F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1201294:BN140 RS07010
gene id: 1201294:BN140_RS07010
uniprot id: I7LJT9
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS04145
gene id: 1201294:BN140_RS04145
uniprot id: I7J7X0
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08800
gene id: 1201294:BN140_RS08800
uniprot id: W6PQI2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1201294:BN140 RS02300
gene id: 1201294:BN140_RS02300
uniprot id: I7KBE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS01295
gene id: 1201294:BN140_RS01295
uniprot id: I7KXI5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS12725
gene id: 1201294:BN140_RS12725
uniprot id: I7L1L4
names: Similarity
messages: Belongs to the LOR family.

1201294:BN140 RS10770
gene id: 1201294:BN140_RS10770
uniprot id: I7LNH2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS07590
gene id: 1201294:BN140_RS07590
uniprot id: I7LMP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1201294:BN140 RS00925
gene id: 1201294:BN140_RS00925
uniprot id: I7KXE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1201294:BN140 RS05035
gene id: 1201294:BN140_RS05035
uniprot id: I7KCA3
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

1201294:BN140 RS07780
gene id: 1201294:BN140_RS07780
uniprot id: I7J983
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1201294:BN140 RS08060
gene id: 1201294:BN140_RS08060
uniprot id: I7LK23
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS01010
gene id: 1201294:BN140_RS01010
uniprot id: I7LIM7
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

1201294:BN140 RS01335
gene id: 1201294:BN140_RS01335
uniprot id: I7LLA2
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1201294:BN140 RS02400
gene id: 1201294:BN140_RS02400
uniprot id: I7LIX6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1201294:BN140 RS00695
gene id: 1201294:BN140_RS00695
uniprot id: I7LL50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

1201294:BN140 RS01655
gene id: 1201294:BN140_RS01655
uniprot id: I7LLC9
names: Similarity
messages: Belongs to the phosphoribulokinase family.

1201294:BN140 RS08535
gene id: 1201294:BN140_RS08535
uniprot id: I7LK53
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1201294:BN140 RS00625
gene id: 1201294:BN140_RS00625
uniprot id: I7LL44
names: Similarity
messages: Belongs to the carbamate kinase family.

1201294:BN140 RS02915
gene id: 1201294:BN140_RS02915
uniprot id: I7LLN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1201294:BN140 RS02440
gene id: 1201294:BN140_RS02440
uniprot id: I7KXY2
names: Similarity
messages: Belongs to the peptidase C56 family.

1201294:BN140 RS09965
gene id: 1201294:BN140_RS09965
uniprot id: I7KDJ8
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1201294:BN140 RS05890
gene id: 1201294:BN140_RS05890
uniprot id: I7J8I5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1201294:BN140 RS00685
gene id: 1201294:BN140_RS00685
uniprot id: I7LIK7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1201294:BN140 RS12620
gene id: 1201294:BN140_RS12620
uniprot id: I7KE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

1201294:BN140 RS01820
gene id: 1201294:BN140_RS01820
uniprot id: I7LIT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1201294:BN140 RS00660
gene id: 1201294:BN140_RS00660
uniprot id: I7LIK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS02860
gene id: 1201294:BN140_RS02860
uniprot id: I7KY46
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1201294:BN140 RS03595
gene id: 1201294:BN140_RS03595
uniprot id: I7LLT7
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1201294:BN140 RS09710
gene id: 1201294:BN140_RS09710
uniprot id: I7J9W4
names: Subunit
messages: Homotetramer.

1201294:BN140 RS12050
gene id: 1201294:BN140_RS12050
uniprot id: I7LKV4
names: Similarity
messages: Belongs to the UPF0210 family.

1201294:BN140 RS11760
gene id: 1201294:BN140_RS11760
uniprot id: I7LKT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1201294:BN140 RS12545
gene id: 1201294:BN140_RS12545
uniprot id: W6Q8V3
names: Subcellular Location Annotation
messages: Cell membrane

1201294:BN140 RS07480
gene id: 1201294:BN140_RS07480
uniprot id: I7KD12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS00555
gene id: 1201294:BN140_RS00555
uniprot id: I7LL38
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1201294:BN140 RS10810
gene id: 1201294:BN140_RS10810
uniprot id: I7LKL5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1201294:BN140 RS04015
gene id: 1201294:BN140_RS04015
uniprot id: I7LJ81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1201294:BN140 RS10845
gene id: 1201294:BN140_RS10845
uniprot id: I7L0W7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS08675
gene id: 1201294:BN140_RS08675
uniprot id: I7LMZ7
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

1201294:BN140 RS09085
gene id: 1201294:BN140_RS09085
uniprot id: I7J9P1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1201294:BN140 RS00230
gene id: 1201294:BN140_RS00230
uniprot id: I7LL12
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

1201294:BN140 RS02210
gene id: 1201294:BN140_RS02210
uniprot id: I7LIW1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1201294:BN140 RS09590
gene id: 1201294:BN140_RS09590
uniprot id: I7L0F9
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1201294:BN140 RS01305
gene id: 1201294:BN140_RS01305
uniprot id: I7LIP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS02280
gene id: 1201294:BN140_RS02280
uniprot id: I7LIW7
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS02520
gene id: 1201294:BN140_RS02520
uniprot id: I7LLJ3
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08460
gene id: 1201294:BN140_RS08460
uniprot id: I7LK48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1201294:BN140 RS06255
gene id: 1201294:BN140_RS06255
uniprot id: I7J8M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

1201294:BN140 RS00645
gene id: 1201294:BN140_RS00645
uniprot id: I7J743
names: Similarity
messages: Belongs to the HerA family.

1201294:BN140 RS00095
gene id: 1201294:BN140_RS00095
uniprot id: I7LKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1201294:BN140 RS12030
gene id: 1201294:BN140_RS12030
uniprot id: I7JAT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS11665
gene id: 1201294:BN140_RS11665
uniprot id: I7LKS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS12375
gene id: 1201294:BN140_RS12375
uniprot id: I7L1G0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1201294:BN140 RS05725
gene id: 1201294:BN140_RS05725
uniprot id: I7LJK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1201294:BN140 RS02220
gene id: 1201294:BN140_RS02220
uniprot id: I7LLH3
names: Similarity
messages: Belongs to the archaeal-type GPI family.

1201294:BN140 RS04020
gene id: 1201294:BN140_RS04020
uniprot id: I7J7V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1201294:BN140 RS09680
gene id: 1201294:BN140_RS09680
uniprot id: I7J9V9
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS08635
gene id: 1201294:BN140_RS08635
uniprot id: I7KDA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1201294:BN140 RS07915
gene id: 1201294:BN140_RS07915
uniprot id: I7LMT7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1201294:BN140 RS04520
gene id: 1201294:BN140_RS04520
uniprot id: I7LJB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1201294:BN140 RS10170
gene id: 1201294:BN140_RS10170
uniprot id: I7L0Q7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1201294:BN140 RS05780
gene id: 1201294:BN140_RS05780
uniprot id: I7J8H1
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08920
gene id: 1201294:BN140_RS08920
uniprot id: I7J9L9
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS10050
gene id: 1201294:BN140_RS10050
uniprot id: I7JA21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1201294:BN140 RS11465
gene id: 1201294:BN140_RS11465
uniprot id: I7LKR3
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS06010
gene id: 1201294:BN140_RS06010
uniprot id: I7KZ75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS04375
gene id: 1201294:BN140_RS04375
uniprot id: I7LLZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1201294:BN140 RS00665
gene id: 1201294:BN140_RS00665
uniprot id: I7J745
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS04380
gene id: 1201294:BN140_RS04380
uniprot id: I7KYL4
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

1201294:BN140 RS12945
gene id: 1201294:BN140_RS12945
uniprot id: I7LL13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS09495
gene id: 1201294:BN140_RS09495
uniprot id: I7LKB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS04590
gene id: 1201294:BN140_RS04590
uniprot id: I7KYP3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1201294:BN140 RS02285
gene id: 1201294:BN140_RS02285
uniprot id: I7J7G1
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08865
gene id: 1201294:BN140_RS08865
uniprot id: I7J9L3
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05545
gene id: 1201294:BN140_RS05545
uniprot id: I7KZ29
names: Similarity
messages: Belongs to the AHA1 family.

1201294:BN140 RS08435
gene id: 1201294:BN140_RS08435
uniprot id: I7LK46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1201294:BN140 RS06685
gene id: 1201294:BN140_RS06685
uniprot id: I7LMH9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1201294:BN140 RS00035
gene id: 1201294:BN140_RS00035
uniprot id: I7KAM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1201294:BN140 RS07445
gene id: 1201294:BN140_RS07445
uniprot id: I7LMN7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1201294:BN140 RS04455
gene id: 1201294:BN140_RS04455
uniprot id: I7LM01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1201294:BN140 RS08840
gene id: 1201294:BN140_RS08840
uniprot id: I7LK73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS11355
gene id: 1201294:BN140_RS11355
uniprot id: I7LNL9
names: Similarity
messages: Belongs to the PurH family.

1201294:BN140 RS08700
gene id: 1201294:BN140_RS08700
uniprot id: I7LMZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1201294:BN140 RS07325
gene id: 1201294:BN140_RS07325
uniprot id: I7KCZ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1201294:BN140 RS07440
gene id: 1201294:BN140_RS07440
uniprot id: I7J913
names: Similarity
messages: Belongs to the DMRL synthase family.

1201294:BN140 RS03835
gene id: 1201294:BN140_RS03835
uniprot id: I7LJ68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1201294:BN140 RS01545
gene id: 1201294:BN140_RS01545
uniprot id: I7LIR5
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1201294:BN140 RS01815
gene id: 1201294:BN140_RS01815
uniprot id: I7KB76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS07045
gene id: 1201294:BN140_RS07045
uniprot id: I7LML0
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1201294:BN140 RS04870
gene id: 1201294:BN140_RS04870
uniprot id: I7KYT2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1201294:BN140 RS08400
gene id: 1201294:BN140_RS08400
uniprot id: I7L016
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1201294:BN140 RS05345
gene id: 1201294:BN140_RS05345
uniprot id: I7J8C2
names: Similarity
messages: Belongs to the UPF0284 family.

1201294:BN140 RS02940
gene id: 1201294:BN140_RS02940
uniprot id: I7LLN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1201294:BN140 RS08470
gene id: 1201294:BN140_RS08470
uniprot id: I7LMY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1201294:BN140 RS07115
gene id: 1201294:BN140_RS07115
uniprot id: I7J8X1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1201294:BN140 RS04445
gene id: 1201294:BN140_RS04445
uniprot id: I7LJB2
names: Similarity
messages: Belongs to the MtxX family.

1201294:BN140 RS07055
gene id: 1201294:BN140_RS07055
uniprot id: I7KCX9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1201294:BN140 RS01485
gene id: 1201294:BN140_RS01485
uniprot id: I7KXK5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

1201294:BN140 RS08160
gene id: 1201294:BN140_RS08160
uniprot id: I7KD75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1201294:BN140 RS08385
gene id: 1201294:BN140_RS08385
uniprot id: I7LK43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1201294:BN140 RS10175
gene id: 1201294:BN140_RS10175
uniprot id: I7LKH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

1201294:BN140 RS01470
gene id: 1201294:BN140_RS01470
uniprot id: I7LIR0
names: Similarity
messages: Belongs to the PDCD5 family.

1201294:BN140 RS05600
gene id: 1201294:BN140_RS05600
uniprot id: I7KCI7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS02075
gene id: 1201294:BN140_RS02075
uniprot id: I7LIV3
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS06745
gene id: 1201294:BN140_RS06745
uniprot id: I7LJR8
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1201294:BN140 RS07910
gene id: 1201294:BN140_RS07910
uniprot id: I7J997
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1201294:BN140 RS05300
gene id: 1201294:BN140_RS05300
uniprot id: I7J8B6
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS06070
gene id: 1201294:BN140_RS06070
uniprot id: I7J8K2
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1201294:BN140 RS05370
gene id: 1201294:BN140_RS05370
uniprot id: I7J8C5
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

1201294:BN140 RS11545
gene id: 1201294:BN140_RS11545
uniprot id: I7LNN4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS03405
gene id: 1201294:BN140_RS03405
uniprot id: I7KBS4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS01565
gene id: 1201294:BN140_RS01565
uniprot id: I7KXL2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1201294:BN140 RS01530
gene id: 1201294:BN140_RS01530
uniprot id: I7LLB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1201294:BN140 RS08090
gene id: 1201294:BN140_RS08090
uniprot id: I7LK24
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

1201294:BN140 RS03815
gene id: 1201294:BN140_RS03815
uniprot id: I7J7T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1201294:BN140 RS00415
gene id: 1201294:BN140_RS00415
uniprot id: I7LII8
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05585
gene id: 1201294:BN140_RS05585
uniprot id: I7LJJ8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1201294:BN140 RS00215
gene id: 1201294:BN140_RS00215
uniprot id: I7LIH4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS07125
gene id: 1201294:BN140_RS07125
uniprot id: I7KZL7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1201294:BN140 RS03085
gene id: 1201294:BN140_RS03085
uniprot id: I7KBP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1201294:BN140 RS01800
gene id: 1201294:BN140_RS01800
uniprot id: I7J7C9
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1201294:BN140 RS07710
gene id: 1201294:BN140_RS07710
uniprot id: I7J974
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS00780
gene id: 1201294:BN140_RS00780
uniprot id: I7LL57
names: Similarity
messages: Belongs to the peptidase U62 family.

1201294:BN140 RS09770
gene id: 1201294:BN140_RS09770
uniprot id: I7L0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1201294:BN140 RS07515
gene id: 1201294:BN140_RS07515
uniprot id: I7J922
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1201294:BN140 RS08500
gene id: 1201294:BN140_RS08500
uniprot id: I7L024
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

1201294:BN140 RS04205
gene id: 1201294:BN140_RS04205
uniprot id: I7KYJ1
names: Similarity
messages: Belongs to the HerA family.

1201294:BN140 RS01750
gene id: 1201294:BN140_RS01750
uniprot id: I7J7C6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1201294:BN140 RS07390
gene id: 1201294:BN140_RS07390
uniprot id: I7LMN5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1201294:BN140 RS05720
gene id: 1201294:BN140_RS05720
uniprot id: I7KCJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1201294:BN140 RS01200
gene id: 1201294:BN140_RS01200
uniprot id: I7KB11
names: Similarity
messages: Belongs to the glutamate synthase family.

1201294:BN140 RS04560
gene id: 1201294:BN140_RS04560
uniprot id: I7LM09
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1201294:BN140 RS00725
gene id: 1201294:BN140_RS00725
uniprot id: I7LL53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1201294:BN140 RS06940
gene id: 1201294:BN140_RS06940
uniprot id: I7LJT3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1201294:BN140 RS09575
gene id: 1201294:BN140_RS09575
uniprot id: I7LKC1
names: Similarity
messages: Belongs to the HMBS family.

1201294:BN140 RS01505
gene id: 1201294:BN140_RS01505
uniprot id: I7LLB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1201294:BN140 RS04050
gene id: 1201294:BN140_RS04050
uniprot id: I7LLX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1201294:BN140 RS03390
gene id: 1201294:BN140_RS03390
uniprot id: I7J7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1201294:BN140 RS05350
gene id: 1201294:BN140_RS05350
uniprot id: I7LM75
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1201294:BN140 RS09950
gene id: 1201294:BN140_RS09950
uniprot id: I7JA06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1201294:BN140 RS02345
gene id: 1201294:BN140_RS02345
uniprot id: I7KXW9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1201294:BN140 RS12730
gene id: 1201294:BN140_RS12730
uniprot id: I7KE58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1201294:BN140 RS12270
gene id: 1201294:BN140_RS12270
uniprot id: I7JAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1201294:BN140 RS09230
gene id: 1201294:BN140_RS09230
uniprot id: I7J9Q7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1201294:BN140 RS07990
gene id: 1201294:BN140_RS07990
uniprot id: I7J9A8
names: Similarity
messages: Belongs to the peptidase M24B family.

1201294:BN140 RS06175
gene id: 1201294:BN140_RS06175
uniprot id: I7J8L4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08530
gene id: 1201294:BN140_RS08530
uniprot id: I7KDA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1201294:BN140 RS13095
gene id: 1201294:BN140_RS13095
uniprot id: I7LMB7
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1201294:BN140 RS03050
gene id: 1201294:BN140_RS03050
uniprot id: I7KY65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1201294:BN140 RS12810
gene id: 1201294:BN140_RS12810
uniprot id: I7KE63
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS04175
gene id: 1201294:BN140_RS04175
uniprot id: I7LLY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS08895
gene id: 1201294:BN140_RS08895
uniprot id: I7LK76
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1201294:BN140 RS03850
gene id: 1201294:BN140_RS03850
uniprot id: I7KYE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1201294:BN140 RS04565
gene id: 1201294:BN140_RS04565
uniprot id: I7KYN9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1201294:BN140 RS02875
gene id: 1201294:BN140_RS02875
uniprot id: I7J7L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

1201294:BN140 RS05825
gene id: 1201294:BN140_RS05825
uniprot id: I7KCK9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1201294:BN140 RS00670
gene id: 1201294:BN140_RS00670
uniprot id: I7LL48
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1201294:BN140 RS11045
gene id: 1201294:BN140_RS11045
uniprot id: I7KDS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1201294:BN140 RS05715
gene id: 1201294:BN140_RS05715
uniprot id: I7KZ48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1201294:BN140 RS07355
gene id: 1201294:BN140_RS07355
uniprot id: I7LJW5
names: Similarity
messages: Belongs to the UPF0179 family.

1201294:BN140 RS04270
gene id: 1201294:BN140_RS04270
uniprot id: I7LLY8
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1201294:BN140 RS02855
gene id: 1201294:BN140_RS02855
uniprot id: I7LLM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1201294:BN140 RS00385
gene id: 1201294:BN140_RS00385
uniprot id: I7KAT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1201294:BN140 RS12625
gene id: 1201294:BN140_RS12625
uniprot id: I7LKZ7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1201294:BN140 RS00860
gene id: 1201294:BN140_RS00860
uniprot id: I7KXE1
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1201294:BN140 RS06425
gene id: 1201294:BN140_RS06425
uniprot id: I7LJP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1201294:BN140 RS03560
gene id: 1201294:BN140_RS03560
uniprot id: I7LJ48
names: Similarity
messages: Belongs to the LOR family.

1201294:BN140 RS02935
gene id: 1201294:BN140_RS02935
uniprot id: I7J7L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1201294:BN140 RS01045
gene id: 1201294:BN140_RS01045
uniprot id: I7J770
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS05025
gene id: 1201294:BN140_RS05025
uniprot id: I7LM39
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1201294:BN140 RS02605
gene id: 1201294:BN140_RS02605
uniprot id: I7KBI6
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

1201294:BN140 RS00835
gene id: 1201294:BN140_RS00835
uniprot id: I7KXD7
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1201294:BN140 RS02570
gene id: 1201294:BN140_RS02570
uniprot id: I7LLJ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS04740
gene id: 1201294:BN140_RS04740
uniprot id: I7LM23
names: Similarity
messages: Belongs to the UPF0310 family.

1201294:BN140 RS00930
gene id: 1201294:BN140_RS00930
uniprot id: I7KAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1201294:BN140 RS01245
gene id: 1201294:BN140_RS01245
uniprot id: I7KB15
names: Similarity
messages: Belongs to the TrpF family.

1201294:BN140 RS09635
gene id: 1201294:BN140_RS09635
uniprot id: I7LN71
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS05845
gene id: 1201294:BN140_RS05845
uniprot id: I7J8H9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1201294:BN140 RS07890
gene id: 1201294:BN140_RS07890
uniprot id: W6PW20
names: Function
messages: Part of a potassium transport system.

1201294:BN140 RS11170
gene id: 1201294:BN140_RS11170
uniprot id: I7L0Z7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1201294:BN140 RS05310
gene id: 1201294:BN140_RS05310
uniprot id: I7KZ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1201294:BN140 RS06780
gene id: 1201294:BN140_RS06780
uniprot id: I7LMI8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1201294:BN140 RS04235
gene id: 1201294:BN140_RS04235
uniprot id: I7J7Y1
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

1201294:BN140 RS10800
gene id: 1201294:BN140_RS10800
uniprot id: I7L0W5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1201294:BN140 RS02160
gene id: 1201294:BN140_RS02160
uniprot id: W6PVZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1201294:BN140 RS00770
gene id: 1201294:BN140_RS00770
uniprot id: I7LIL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1201294:BN140 RS03060
gene id: 1201294:BN140_RS03060
uniprot id: I7LJ13
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS06510
gene id: 1201294:BN140_RS06510
uniprot id: I7LMG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS08475
gene id: 1201294:BN140_RS08475
uniprot id: I7L021
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1201294:BN140 RS03880
gene id: 1201294:BN140_RS03880
uniprot id: I7LJ72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1201294:BN140 RS06890
gene id: 1201294:BN140_RS06890
uniprot id: I7LJS9
names: Similarity
messages: Belongs to the HerA family.

1201294:BN140 RS00960
gene id: 1201294:BN140_RS00960
uniprot id: I7LIM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1201294:BN140 RS06715
gene id: 1201294:BN140_RS06715
uniprot id: I7KCU6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS02260
gene id: 1201294:BN140_RS02260
uniprot id: I7LIW5
names: Subcellular Location Annotation
messages: Cytoplasm

1201294:BN140 RS04530
gene id: 1201294:BN140_RS04530
uniprot id: I7LM07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1201294:BN140 RS02930
gene id: 1201294:BN140_RS02930
uniprot id: I7LJ06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS10210
gene id: 1201294:BN140_RS10210
uniprot id: I7LNC6
names: Similarity
messages: Belongs to the UPF0107 family.

1201294:BN140 RS07800
gene id: 1201294:BN140_RS07800
uniprot id: I7LK06
names: Similarity
messages: Belongs to the glutamate synthase family.

1201294:BN140 RS12905
gene id: 1201294:BN140_RS12905
uniprot id: W6PR20
names: Similarity
messages: Belongs to the IMPACT family.

1201294:BN140 RS10715
gene id: 1201294:BN140_RS10715
uniprot id: I7LNG6
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS06505
gene id: 1201294:BN140_RS06505
uniprot id: I7J8P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1201294:BN140 RS03485
gene id: 1201294:BN140_RS03485
uniprot id: I7KBT2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1201294:BN140 RS02500
gene id: 1201294:BN140_RS02500
uniprot id: I7KXZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS00040
gene id: 1201294:BN140_RS00040
uniprot id: I7LIF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1201294:BN140 RS14510
gene id: 1201294:BN140_RS14510
uniprot id: I7J9R3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1201294:BN140 RS03580
gene id: 1201294:BN140_RS03580
uniprot id: I7LJ50
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1201294:BN140 RS06340
gene id: 1201294:BN140_RS06340
uniprot id: I7KZB3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1201294:BN140 RS06930
gene id: 1201294:BN140_RS06930
uniprot id: I7KZJ1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1201294:BN140 RS06465
gene id: 1201294:BN140_RS06465
uniprot id: I7KCS3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1201294:BN140 RS05805
gene id: 1201294:BN140_RS05805
uniprot id: I7J8H3
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS10795
gene id: 1201294:BN140_RS10795
uniprot id: I7LNH4
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

1201294:BN140 RS00825
gene id: 1201294:BN140_RS00825
uniprot id: I7J756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1201294:BN140 RS09665
gene id: 1201294:BN140_RS09665
uniprot id: I7L0H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1201294:BN140 RS02675
gene id: 1201294:BN140_RS02675
uniprot id: I7KY30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS03855
gene id: 1201294:BN140_RS03855
uniprot id: I7KBW5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1201294:BN140 RS00810
gene id: 1201294:BN140_RS00810
uniprot id: I7KXD4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS11750
gene id: 1201294:BN140_RS11750
uniprot id: I7L178
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1201294:BN140 RS02880
gene id: 1201294:BN140_RS02880
uniprot id: I7LLN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS12680
gene id: 1201294:BN140_RS12680
uniprot id: I7KE55
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS06265
gene id: 1201294:BN140_RS06265
uniprot id: I7KZA3
names: Similarity
messages: Belongs to the FwdC/FmdC family.

1201294:BN140 RS07835
gene id: 1201294:BN140_RS07835
uniprot id: I7LMT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1201294:BN140 RS10990
gene id: 1201294:BN140_RS10990
uniprot id: I7L0X9
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS12155
gene id: 1201294:BN140_RS12155
uniprot id: I7LNS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1201294:BN140 RS11455
gene id: 1201294:BN140_RS11455
uniprot id: I7L137
names: Similarity
messages: Belongs to the UPF0235 family.

1201294:BN140 RS04320
gene id: 1201294:BN140_RS04320
uniprot id: I7J7Z0
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS10420
gene id: 1201294:BN140_RS10420
uniprot id: I7KDM5
names: Similarity
messages: Belongs to the acylphosphatase family.

1201294:BN140 RS10435
gene id: 1201294:BN140_RS10435
uniprot id: I7LNE6
names: Similarity
messages: Belongs to the archaeal-type GPI family.

1201294:BN140 RS10840
gene id: 1201294:BN140_RS10840
uniprot id: I7LNH8
names: Subcellular Location Annotation
messages: Cytoplasm

1201294:BN140 RS12995
gene id: 1201294:BN140_RS12995
uniprot id: I7LL17
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1201294:BN140 RS03400
gene id: 1201294:BN140_RS03400
uniprot id: I7KYA4
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

1201294:BN140 RS11460
gene id: 1201294:BN140_RS11460
uniprot id: I7KDV6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS08680
gene id: 1201294:BN140_RS08680
uniprot id: I7L043
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1201294:BN140 RS04415
gene id: 1201294:BN140_RS04415
uniprot id: I7KC21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS10115
gene id: 1201294:BN140_RS10115
uniprot id: I7LNB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1201294:BN140 RS08660
gene id: 1201294:BN140_RS08660
uniprot id: I7KDB1
names: Similarity
messages: Belongs to the FwdC/FmdC family.

1201294:BN140 RS09560
gene id: 1201294:BN140_RS09560
uniprot id: I7LN65
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1201294:BN140 RS09165
gene id: 1201294:BN140_RS09165
uniprot id: I7J9P8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1201294:BN140 RS11605
gene id: 1201294:BN140_RS11605
uniprot id: I7L157
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1201294:BN140 RS01910
gene id: 1201294:BN140_RS01910
uniprot id: I7J7D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS02445
gene id: 1201294:BN140_RS02445
uniprot id: I7KBG5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

1201294:BN140 RS00370
gene id: 1201294:BN140_RS00370
uniprot id: I7J724
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1201294:BN140 RS08270
gene id: 1201294:BN140_RS08270
uniprot id: I7KD82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1201294:BN140 RS11155
gene id: 1201294:BN140_RS11155
uniprot id: I7LKP0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS11295
gene id: 1201294:BN140_RS11295
uniprot id: I7JAK2
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1201294:BN140 RS00940
gene id: 1201294:BN140_RS00940
uniprot id: I7J763
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1201294:BN140 RS07230
gene id: 1201294:BN140_RS07230
uniprot id: I7KZN1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS08440
gene id: 1201294:BN140_RS08440
uniprot id: I7J9G2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1201294:BN140 RS02870
gene id: 1201294:BN140_RS02870
uniprot id: I7LJ03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS11685
gene id: 1201294:BN140_RS11685
uniprot id: I7KDX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS05755
gene id: 1201294:BN140_RS05755
uniprot id: I7J8G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1201294:BN140 RS03540
gene id: 1201294:BN140_RS03540
uniprot id: I7J7R2
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS02715
gene id: 1201294:BN140_RS02715
uniprot id: I7J7K6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1201294:BN140 RS11450
gene id: 1201294:BN140_RS11450
uniprot id: I7LNM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1201294:BN140 RS14560
gene id: 1201294:BN140_RS14560
uniprot id: I7JAE3
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1201294:BN140 RS03150
gene id: 1201294:BN140_RS03150
uniprot id: I7LLQ2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

1201294:BN140 RS02120
gene id: 1201294:BN140_RS02120
uniprot id: I7LLG5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1201294:BN140 RS06015
gene id: 1201294:BN140_RS06015
uniprot id: I7KCN0
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS09610
gene id: 1201294:BN140_RS09610
uniprot id: I7LN69
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS02480
gene id: 1201294:BN140_RS02480
uniprot id: I7KBH1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1201294:BN140 RS02495
gene id: 1201294:BN140_RS02495
uniprot id: I7LLJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1201294:BN140 RS12405
gene id: 1201294:BN140_RS12405
uniprot id: I7KE31
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1201294:BN140 RS07195
gene id: 1201294:BN140_RS07195
uniprot id: I7LMM2
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

1201294:BN140 RS08650
gene id: 1201294:BN140_RS08650
uniprot id: I7LMZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

1201294:BN140 RS00185
gene id: 1201294:BN140_RS00185
uniprot id: I7KX62
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS09525
gene id: 1201294:BN140_RS09525
uniprot id: I7J9T8
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1201294:BN140 RS11970
gene id: 1201294:BN140_RS11970
uniprot id: I7L1A6
names: Similarity
messages: Belongs to the glutamine synthetase family.

1201294:BN140 RS02310
gene id: 1201294:BN140_RS02310
uniprot id: I7J7G3
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS09855
gene id: 1201294:BN140_RS09855
uniprot id: I7LN83
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1201294:BN140 RS11280
gene id: 1201294:BN140_RS11280
uniprot id: I7LNL3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

1201294:BN140 RS08450
gene id: 1201294:BN140_RS08450
uniprot id: I7L019
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS08425
gene id: 1201294:BN140_RS08425
uniprot id: I7L017
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS00605
gene id: 1201294:BN140_RS00605
uniprot id: I7LL42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS08030
gene id: 1201294:BN140_RS08030
uniprot id: I7LK21
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS11735
gene id: 1201294:BN140_RS11735
uniprot id: I7LKT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS02200
gene id: 1201294:BN140_RS02200
uniprot id: I7KXU8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1201294:BN140 RS00515
gene id: 1201294:BN140_RS00515
uniprot id: I7LIJ5
names: Similarity
messages: Belongs to the aspartokinase family.

1201294:BN140 RS11630
gene id: 1201294:BN140_RS11630
uniprot id: I7L161
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1201294:BN140 RS03035
gene id: 1201294:BN140_RS03035
uniprot id: I7LJ11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS02390
gene id: 1201294:BN140_RS02390
uniprot id: I7KXX5
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS11165
gene id: 1201294:BN140_RS11165
uniprot id: I7LNK3
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1201294:BN140 RS11195
gene id: 1201294:BN140_RS11195
uniprot id: I7KDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

1201294:BN140 RS08210
gene id: 1201294:BN140_RS08210
uniprot id: I7L004
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1201294:BN140 RS00680
gene id: 1201294:BN140_RS00680
uniprot id: I7KAW8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1201294:BN140 RS12140
gene id: 1201294:BN140_RS12140
uniprot id: I7KE10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1201294:BN140 RS00560
gene id: 1201294:BN140_RS00560
uniprot id: I7KAV5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1201294:BN140 RS04265
gene id: 1201294:BN140_RS04265
uniprot id: I7J7Y5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS01230
gene id: 1201294:BN140_RS01230
uniprot id: I7J783
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1201294:BN140 RS10400
gene id: 1201294:BN140_RS10400
uniprot id: I7JA95
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1201294:BN140 RS11175
gene id: 1201294:BN140_RS11175
uniprot id: I7LKP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS11385
gene id: 1201294:BN140_RS11385
uniprot id: I7KDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1201294:BN140 RS12990
gene id: 1201294:BN140_RS12990
uniprot id: I7KE71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS07375
gene id: 1201294:BN140_RS07375
uniprot id: I7KD03
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS03765
gene id: 1201294:BN140_RS03765
uniprot id: I7KBV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1201294:BN140 RS03145
gene id: 1201294:BN140_RS03145
uniprot id: I7J7N3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1201294:BN140 RS00865
gene id: 1201294:BN140_RS00865
uniprot id: I7KAY5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1201294:BN140 RS02340
gene id: 1201294:BN140_RS02340
uniprot id: I7LLI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1201294:BN140 RS08890
gene id: 1201294:BN140_RS08890
uniprot id: I7KDC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

1201294:BN140 RS12135
gene id: 1201294:BN140_RS12135
uniprot id: I7L1C8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1201294:BN140 RS09485
gene id: 1201294:BN140_RS09485
uniprot id: I7KDG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1201294:BN140 RS00015
gene id: 1201294:BN140_RS00015
uniprot id: I7KAM1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1201294:BN140 RS01030
gene id: 1201294:BN140_RS01030
uniprot id: I7KAZ6
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1201294:BN140 RS04995
gene id: 1201294:BN140_RS04995
uniprot id: I7J859
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1201294:BN140 RS07360
gene id: 1201294:BN140_RS07360
uniprot id: I7J903
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

1201294:BN140 RS01935
gene id: 1201294:BN140_RS01935
uniprot id: I7LLF2
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

1201294:BN140 RS09570
gene id: 1201294:BN140_RS09570
uniprot id: I7KDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1201294:BN140 RS01580
gene id: 1201294:BN140_RS01580
uniprot id: I7J7A9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS09220
gene id: 1201294:BN140_RS09220
uniprot id: I7KDF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS02895
gene id: 1201294:BN140_RS02895
uniprot id: I7LJ04
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1201294:BN140 RS01125
gene id: 1201294:BN140_RS01125
uniprot id: I7LL84
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

1201294:BN140 RS07200
gene id: 1201294:BN140_RS07200
uniprot id: I7KZM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

1201294:BN140 RS09545
gene id: 1201294:BN140_RS09545
uniprot id: I7KDH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS03020
gene id: 1201294:BN140_RS03020
uniprot id: I7LLP2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS00130
gene id: 1201294:BN140_RS00130
uniprot id: I7KAP0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS05390
gene id: 1201294:BN140_RS05390
uniprot id: I7LJI6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

1201294:BN140 RS01665
gene id: 1201294:BN140_RS01665
uniprot id: I7KB63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1201294:BN140 RS05970
gene id: 1201294:BN140_RS05970
uniprot id: I7LJM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1201294:BN140 RS05705
gene id: 1201294:BN140_RS05705
uniprot id: I7LJK6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1201294:BN140 RS11340
gene id: 1201294:BN140_RS11340
uniprot id: I7KDU6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1201294:BN140 RS09625
gene id: 1201294:BN140_RS09625
uniprot id: I7LKC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1201294:BN140 RS03840
gene id: 1201294:BN140_RS03840
uniprot id: I7J7T9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1201294:BN140 RS02510
gene id: 1201294:BN140_RS02510
uniprot id: I7LIY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1201294:BN140 RS07450
gene id: 1201294:BN140_RS07450
uniprot id: I7KZQ6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1201294:BN140 RS07425
gene id: 1201294:BN140_RS07425
uniprot id: I7KZQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS06450
gene id: 1201294:BN140_RS06450
uniprot id: I7LJP8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS01115
gene id: 1201294:BN140_RS01115
uniprot id: I7LIN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1201294:BN140 RS01675
gene id: 1201294:BN140_RS01675
uniprot id: I7KXM7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

1201294:BN140 RS07030
gene id: 1201294:BN140_RS07030
uniprot id: I7KCX7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

1201294:BN140 RS04275
gene id: 1201294:BN140_RS04275
uniprot id: I7KYK0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1201294:BN140 RS01210
gene id: 1201294:BN140_RS01210
uniprot id: I7LL92
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1201294:BN140 RS07205
gene id: 1201294:BN140_RS07205
uniprot id: I7KCZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1201294:BN140 RS08795
gene id: 1201294:BN140_RS08795
uniprot id: I7J9K5
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS07730
gene id: 1201294:BN140_RS07730
uniprot id: I7LK01
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1201294:BN140 RS07875
gene id: 1201294:BN140_RS07875
uniprot id: I7LK11
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS02755
gene id: 1201294:BN140_RS02755
uniprot id: I7KY38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1201294:BN140 RS05935
gene id: 1201294:BN140_RS05935
uniprot id: I7KZ69
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1201294:BN140 RS04465
gene id: 1201294:BN140_RS04465
uniprot id: I7KC26
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1201294:BN140 RS02865
gene id: 1201294:BN140_RS02865
uniprot id: I7KBM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS07335
gene id: 1201294:BN140_RS07335
uniprot id: I7J901
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1201294:BN140 RS03455
gene id: 1201294:BN140_RS03455
uniprot id: I7KYA9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1201294:BN140 RS07775
gene id: 1201294:BN140_RS07775
uniprot id: I7LK05
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1201294:BN140 RS09305
gene id: 1201294:BN140_RS09305
uniprot id: I7KDF7
names: Similarity
messages: Belongs to the HsdR family.

1201294:BN140 RS03805
gene id: 1201294:BN140_RS03805
uniprot id: I7LLV1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1201294:BN140 RS04260
gene id: 1201294:BN140_RS04260
uniprot id: I7LJ99
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

1201294:BN140 RS09700
gene id: 1201294:BN140_RS09700
uniprot id: I7LKC6
names: Similarity
messages: Belongs to the UPF0215 family.

1201294:BN140 RS05980
gene id: 1201294:BN140_RS05980
uniprot id: I7LMC4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS01150
gene id: 1201294:BN140_RS01150
uniprot id: I7LL86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

1201294:BN140 RS01490
gene id: 1201294:BN140_RS01490
uniprot id: I7KB44
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1201294:BN140 RS02740
gene id: 1201294:BN140_RS02740
uniprot id: I7LIZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1201294:BN140 RS08845
gene id: 1201294:BN140_RS08845
uniprot id: I7J9L1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS10090
gene id: 1201294:BN140_RS10090
uniprot id: I7LNA3
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1201294:BN140 RS01405
gene id: 1201294:BN140_RS01405
uniprot id: I7LLA8
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS07120
gene id: 1201294:BN140_RS07120
uniprot id: I7LML6
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1201294:BN140 RS03830
gene id: 1201294:BN140_RS03830
uniprot id: I7KBW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS08510
gene id: 1201294:BN140_RS08510
uniprot id: I7LK51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1201294:BN140 RS07520
gene id: 1201294:BN140_RS07520
uniprot id: I7LMP0
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

1201294:BN140 RS06660
gene id: 1201294:BN140_RS06660
uniprot id: I7J8Q7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1201294:BN140 RS02050
gene id: 1201294:BN140_RS02050
uniprot id: I7LIV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS03375
gene id: 1201294:BN140_RS03375
uniprot id: I7KYA1
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS12685
gene id: 1201294:BN140_RS12685
uniprot id: I7LKZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1201294:BN140 RS07050
gene id: 1201294:BN140_RS07050
uniprot id: I7KZK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1201294:BN140 RS07550
gene id: 1201294:BN140_RS07550
uniprot id: I7KZR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1201294:BN140 RS02745
gene id: 1201294:BN140_RS02745
uniprot id: I7J7K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS12485
gene id: 1201294:BN140_RS12485
uniprot id: I7LKY5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1201294:BN140 RS06525
gene id: 1201294:BN140_RS06525
uniprot id: I7LJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS09365
gene id: 1201294:BN140_RS09365
uniprot id: I7LKA8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1201294:BN140 RS06855
gene id: 1201294:BN140_RS06855
uniprot id: I7KZI3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1201294:BN140 RS07250
gene id: 1201294:BN140_RS07250
uniprot id: I7LMM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1201294:BN140 RS09260
gene id: 1201294:BN140_RS09260
uniprot id: I7LN43
names: Similarity
messages: Belongs to the UPF0280 family.

1201294:BN140 RS03155
gene id: 1201294:BN140_RS03155
uniprot id: I7KY77
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1201294:BN140 RS02405
gene id: 1201294:BN140_RS02405
uniprot id: I7J7H1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1201294:BN140 RS11420
gene id: 1201294:BN140_RS11420
uniprot id: I7JAL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS09960
gene id: 1201294:BN140_RS09960
uniprot id: I7L0L2
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05855
gene id: 1201294:BN140_RS05855
uniprot id: I7KZ63
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1201294:BN140 RS11345
gene id: 1201294:BN140_RS11345
uniprot id: I7LKQ4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1201294:BN140 RS07315
gene id: 1201294:BN140_RS07315
uniprot id: I7LMN0
names: Similarity
messages: Belongs to the eIF-2-alpha family.

1201294:BN140 RS11380
gene id: 1201294:BN140_RS11380
uniprot id: I7LNM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1201294:BN140 RS09875
gene id: 1201294:BN140_RS09875
uniprot id: I7LN85
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1201294:BN140 RS03935
gene id: 1201294:BN140_RS03935
uniprot id: I7KBX2
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

1201294:BN140 RS08690
gene id: 1201294:BN140_RS08690
uniprot id: I7LK63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1201294:BN140 RS08525
gene id: 1201294:BN140_RS08525
uniprot id: I7L027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1201294:BN140 RS06220
gene id: 1201294:BN140_RS06220
uniprot id: I7KCQ0
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08295
gene id: 1201294:BN140_RS08295
uniprot id: I7J9E4
names: Similarity
messages: Belongs to the acylphosphatase family.

1201294:BN140 RS01330
gene id: 1201294:BN140_RS01330
uniprot id: I7LIP9
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS05915
gene id: 1201294:BN140_RS05915
uniprot id: I7LJM0
names: Similarity
messages: Belongs to the HypD family.

1201294:BN140 RS12150
gene id: 1201294:BN140_RS12150
uniprot id: I7JAU9
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS12645
gene id: 1201294:BN140_RS12645
uniprot id: I7L1K6
names: Similarity
messages: Belongs to the UPF0251 family.

1201294:BN140 RS00540
gene id: 1201294:BN140_RS00540
uniprot id: I7KAV2
names: Similarity
messages: Belongs to the ZPR1 family.

1201294:BN140 RS08410
gene id: 1201294:BN140_RS08410
uniprot id: I7LK45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS08480
gene id: 1201294:BN140_RS08480
uniprot id: I7KD98
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1201294:BN140 RS00885
gene id: 1201294:BN140_RS00885
uniprot id: I7LL65
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

1201294:BN140 RS04555
gene id: 1201294:BN140_RS04555
uniprot id: I7J816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1201294:BN140 RS00485
gene id: 1201294:BN140_RS00485
uniprot id: I7KAU6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1201294:BN140 RS07485
gene id: 1201294:BN140_RS07485
uniprot id: I7LJX5
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS11615
gene id: 1201294:BN140_RS11615
uniprot id: I7LKS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1201294:BN140 RS00650
gene id: 1201294:BN140_RS00650
uniprot id: I7LL46
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1201294:BN140 RS08665
gene id: 1201294:BN140_RS08665
uniprot id: I7LK61
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1201294:BN140 RS07260
gene id: 1201294:BN140_RS07260
uniprot id: I7KCZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1201294:BN140 RS06035
gene id: 1201294:BN140_RS06035
uniprot id: I7KCN3
names: Similarity
messages: Belongs to the UPF0047 family.

1201294:BN140 RS08100
gene id: 1201294:BN140_RS08100
uniprot id: I7LMV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS05470
gene id: 1201294:BN140_RS05470
uniprot id: I7J8D6
names: Similarity
messages: Belongs to the HerA family.

1201294:BN140 RS01570
gene id: 1201294:BN140_RS01570
uniprot id: I7KB53
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1201294:BN140 RS11160
gene id: 1201294:BN140_RS11160
uniprot id: I7JAI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS11670
gene id: 1201294:BN140_RS11670
uniprot id: I7JAP6
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS12295
gene id: 1201294:BN140_RS12295
uniprot id: I7JAW1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS08515
gene id: 1201294:BN140_RS08515
uniprot id: I7J9H1
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1201294:BN140 RS07790
gene id: 1201294:BN140_RS07790
uniprot id: I7KZW3
names: Similarity
messages: Belongs to the glutamine synthetase family.

1201294:BN140 RS07935
gene id: 1201294:BN140_RS07935
uniprot id: I7LK15
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1201294:BN140 RS11290
gene id: 1201294:BN140_RS11290
uniprot id: I7KDU2
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1201294:BN140 RS01510
gene id: 1201294:BN140_RS01510
uniprot id: I7KXK8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1201294:BN140 RS04255
gene id: 1201294:BN140_RS04255
uniprot id: I7KC06
names: Subcellular Location Annotation
messages: cilium

1201294:BN140 RS06860
gene id: 1201294:BN140_RS06860
uniprot id: I7KCW2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1201294:BN140 RS02725
gene id: 1201294:BN140_RS02725
uniprot id: I7KY36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

1201294:BN140 RS00755
gene id: 1201294:BN140_RS00755
uniprot id: I7LL55
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1201294:BN140 RS08710
gene id: 1201294:BN140_RS08710
uniprot id: I7KDB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1201294:BN140 RS11390
gene id: 1201294:BN140_RS11390
uniprot id: I7LKQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1201294:BN140 RS01480
gene id: 1201294:BN140_RS01480
uniprot id: I7LLB4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1201294:BN140 RS06530
gene id: 1201294:BN140_RS06530
uniprot id: I7J8P6
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

1201294:BN140 RS00955
gene id: 1201294:BN140_RS00955
uniprot id: I7KAZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1201294:BN140 RS00915
gene id: 1201294:BN140_RS00915
uniprot id: I7J761
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

1201294:BN140 RS07175
gene id: 1201294:BN140_RS07175
uniprot id: I7KZM4
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

1201294:BN140 RS07615
gene id: 1201294:BN140_RS07615
uniprot id: I7LMP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

1201294:BN140 RS07245
gene id: 1201294:BN140_RS07245
uniprot id: I7J8Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS11885
gene id: 1201294:BN140_RS11885
uniprot id: I7LKU2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1201294:BN140 RS04475
gene id: 1201294:BN140_RS04475
uniprot id: I7J807
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

1201294:BN140 RS13230
gene id: 1201294:BN140_RS13230
uniprot id: I7KXA4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1201294:BN140 RS07240
gene id: 1201294:BN140_RS07240
uniprot id: I7LJV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1201294:BN140 RS13185
gene id: 1201294:BN140_RS13185
uniprot id: I7KDV2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1201294:BN140 RS09405
gene id: 1201294:BN140_RS09405
uniprot id: I7L0D7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1201294:BN140 RS08720
gene id: 1201294:BN140_RS08720
uniprot id: I7J9J6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1201294:BN140 RS10365
gene id: 1201294:BN140_RS10365
uniprot id: I7KDM1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1201294:BN140 RS03175
gene id: 1201294:BN140_RS03175
uniprot id: I7LLQ4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1201294:BN140 RS02710
gene id: 1201294:BN140_RS02710
uniprot id: I7LIZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1201294:BN140 RS02565
gene id: 1201294:BN140_RS02565
uniprot id: I7J7I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1201294:BN140 RS06475
gene id: 1201294:BN140_RS06475
uniprot id: I7J8P3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

1201294:BN140 RS10165
gene id: 1201294:BN140_RS10165
uniprot id: I7LNC1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS00090
gene id: 1201294:BN140_RS00090
uniprot id: I7J6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS07110
gene id: 1201294:BN140_RS07110
uniprot id: I7LJU7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1201294:BN140 RS09750
gene id: 1201294:BN140_RS09750
uniprot id: I7KDI8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1201294:BN140 RS10900
gene id: 1201294:BN140_RS10900
uniprot id: I7LNI4
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1201294:BN140 RS03755
gene id: 1201294:BN140_RS03755
uniprot id: I7KYD4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

1201294:BN140 RS10850
gene id: 1201294:BN140_RS10850
uniprot id: I7KDQ9
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS03495
gene id: 1201294:BN140_RS03495
uniprot id: I7J7Q8
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1201294:BN140 RS07040
gene id: 1201294:BN140_RS07040
uniprot id: I7J8W0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1201294:BN140 RS07170
gene id: 1201294:BN140_RS07170
uniprot id: I7LMM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

1201294:BN140 RS10125
gene id: 1201294:BN140_RS10125
uniprot id: I7KDK5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1201294:BN140 RS06730
gene id: 1201294:BN140_RS06730
uniprot id: I7LMI3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS08420
gene id: 1201294:BN140_RS08420
uniprot id: I7LMX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1201294:BN140 RS02395
gene id: 1201294:BN140_RS02395
uniprot id: I7KBF7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

1201294:BN140 RS07005
gene id: 1201294:BN140_RS07005
uniprot id: I7KCX5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS02330
gene id: 1201294:BN140_RS02330
uniprot id: I7LIX1
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1201294:BN140 RS09565
gene id: 1201294:BN140_RS09565
uniprot id: I7L0F6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1201294:BN140 RS01095
gene id: 1201294:BN140_RS01095
uniprot id: I7J773
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1201294:BN140 RS01515
gene id: 1201294:BN140_RS01515
uniprot id: I7KB48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1201294:BN140 RS03425
gene id: 1201294:BN140_RS03425
uniprot id: I7KYA6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1201294:BN140 RS11620
gene id: 1201294:BN140_RS11620
uniprot id: I7JAP0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1201294:BN140 RS08685
gene id: 1201294:BN140_RS08685
uniprot id: I7KDB2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1201294:BN140 RS05490
gene id: 1201294:BN140_RS05490
uniprot id: I7J8D8
names: Similarity
messages: Belongs to the HsdR family.

1201294:BN140 RS11680
gene id: 1201294:BN140_RS11680
uniprot id: I7L167
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

1201294:BN140 RS01640
gene id: 1201294:BN140_RS01640
uniprot id: I7KB61
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

1201294:BN140 RS00900
gene id: 1201294:BN140_RS00900
uniprot id: I7LIM1
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS08415
gene id: 1201294:BN140_RS08415
uniprot id: I7J9F9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1201294:BN140 RS01345
gene id: 1201294:BN140_RS01345
uniprot id: I7KXJ2
names: Similarity
messages: Belongs to the SUI1 family.

1201294:BN140 RS07860
gene id: 1201294:BN140_RS07860
uniprot id: I7LMT3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1201294:BN140 RS00050
gene id: 1201294:BN140_RS00050
uniprot id: I7LKZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1201294:BN140 RS08105
gene id: 1201294:BN140_RS08105
uniprot id: I7KZZ3
names: Similarity
messages: Belongs to the UPF0288 family.

1201294:BN140 RS08370
gene id: 1201294:BN140_RS08370
uniprot id: I7LMX2
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

1201294:BN140 RS05695
gene id: 1201294:BN140_RS05695
uniprot id: I7KZ45
names: Similarity
messages: Belongs to the UPF0305 family.

1201294:BN140 RS08430
gene id: 1201294:BN140_RS08430
uniprot id: I7KD94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1201294:BN140 RS12425
gene id: 1201294:BN140_RS12425
uniprot id: I7L1G6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1201294:BN140 RS12520
gene id: 1201294:BN140_RS12520
uniprot id: I7KE40
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS01465
gene id: 1201294:BN140_RS01465
uniprot id: I7KB41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1201294:BN140 RS12320
gene id: 1201294:BN140_RS12320
uniprot id: I7JAW5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1201294:BN140 RS08485
gene id: 1201294:BN140_RS08485
uniprot id: I7LK50
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1201294:BN140 RS11475
gene id: 1201294:BN140_RS11475
uniprot id: I7LNM8
names: Similarity
messages: Belongs to the HypE family.

1201294:BN140 RS03845
gene id: 1201294:BN140_RS03845
uniprot id: I7LLV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1201294:BN140 RS10315
gene id: 1201294:BN140_RS10315
uniprot id: I7LND5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1201294:BN140 RS02385
gene id: 1201294:BN140_RS02385
uniprot id: I7LLI5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1201294:BN140 RS03415
gene id: 1201294:BN140_RS03415
uniprot id: I7J7Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1201294:BN140 RS03885
gene id: 1201294:BN140_RS03885
uniprot id: I7J7U3
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1201294:BN140 RS00950
gene id: 1201294:BN140_RS00950
uniprot id: I7KXF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1201294:BN140 RS06600
gene id: 1201294:BN140_RS06600
uniprot id: I7KCT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1201294:BN140 RS03945
gene id: 1201294:BN140_RS03945
uniprot id: I7J7U7
names: Similarity
messages: Belongs to the thymidylate kinase family.

1201294:BN140 RS00845
gene id: 1201294:BN140_RS00845
uniprot id: I7LIL7
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1201294:BN140 RS12930
gene id: 1201294:BN140_RS12930
uniprot id: I7LNZ4
names: Similarity
messages: Belongs to the DtxR/MntR family.

1201294:BN140 RS11405
gene id: 1201294:BN140_RS11405
uniprot id: I7L129
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS06355
gene id: 1201294:BN140_RS06355
uniprot id: I7J8N2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1201294:BN140 RS12675
gene id: 1201294:BN140_RS12675
uniprot id: I7L1K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1201294:BN140 RS03040
gene id: 1201294:BN140_RS03040
uniprot id: I7J7M6
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS09725
gene id: 1201294:BN140_RS09725
uniprot id: I7KDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1201294:BN140 RS12540
gene id: 1201294:BN140_RS12540
uniprot id: I7LKY9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1201294:BN140 RS06040
gene id: 1201294:BN140_RS06040
uniprot id: I7LJM8
names: Similarity
messages: Belongs to the UPF0147 family.

1201294:BN140 RS10220
gene id: 1201294:BN140_RS10220
uniprot id: I7KDL1
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1201294:BN140 RS04435
gene id: 1201294:BN140_RS04435
uniprot id: I7KYM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1201294:BN140 RS00005
gene id: 1201294:BN140_RS00005
uniprot id: I7LKY8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1201294:BN140 RS03995
gene id: 1201294:BN140_RS03995
uniprot id: I7J7V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1201294:BN140 RS00380
gene id: 1201294:BN140_RS00380
uniprot id: I7KX84
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1201294:BN140 RS06670
gene id: 1201294:BN140_RS06670
uniprot id: I7KZF8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1201294:BN140 RS11625
gene id: 1201294:BN140_RS11625
uniprot id: I7LNP0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1201294:BN140 RS08580
gene id: 1201294:BN140_RS08580
uniprot id: I7L032
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1201294:BN140 RS02920
gene id: 1201294:BN140_RS02920
uniprot id: I7KY52
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1201294:BN140 RS08575
gene id: 1201294:BN140_RS08575
uniprot id: I7LMY9
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

1201294:BN140 RS12630
gene id: 1201294:BN140_RS12630
uniprot id: I7JB17
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1201294:BN140 RS02170
gene id: 1201294:BN140_RS02170
uniprot id: I7J7F1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1201294:BN140 RS08355
gene id: 1201294:BN140_RS08355
uniprot id: I7KD89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS08165
gene id: 1201294:BN140_RS08165
uniprot id: I7LK29
names: Similarity
messages: Belongs to the GroES chaperonin family.

1201294:BN140 RS05400
gene id: 1201294:BN140_RS05400
uniprot id: I7LM79
names: Similarity
messages: Belongs to the NadC/ModD family.

1201294:BN140 RS07530
gene id: 1201294:BN140_RS07530
uniprot id: I7KD17
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS02380
gene id: 1201294:BN140_RS02380
uniprot id: I7J7G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1201294:BN140 RS10225
gene id: 1201294:BN140_RS10225
uniprot id: I7LKH4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1201294:BN140 RS10875
gene id: 1201294:BN140_RS10875
uniprot id: I7LKM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1201294:BN140 RS10305
gene id: 1201294:BN140_RS10305
uniprot id: I7JA82
names: Similarity
messages: Belongs to the RuvC family.

1201294:BN140 RS11370
gene id: 1201294:BN140_RS11370
uniprot id: I7LKQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

1201294:BN140 RS07665
gene id: 1201294:BN140_RS07665
uniprot id: I7LMR4
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS00480
gene id: 1201294:BN140_RS00480
uniprot id: I7LL32
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1201294:BN140 RS09605
gene id: 1201294:BN140_RS09605
uniprot id: I7J9U7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1201294:BN140 RS01265
gene id: 1201294:BN140_RS01265
uniprot id: I7LL96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1201294:BN140 RS11610
gene id: 1201294:BN140_RS11610
uniprot id: I7KDW8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1201294:BN140 RS00495
gene id: 1201294:BN140_RS00495
uniprot id: I7J733
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1201294:BN140 RS13475
gene id: 1201294:BN140_RS13475
uniprot id: I7KZP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

1201294:BN140 RS07830
gene id: 1201294:BN140_RS07830
uniprot id: I7J989
names: Similarity
messages: Belongs to the TPP enzyme family.

1201294:BN140 RS11505
gene id: 1201294:BN140_RS11505
uniprot id: I7L144
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1201294:BN140 RS00970
gene id: 1201294:BN140_RS00970
uniprot id: I7LL71
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS03800
gene id: 1201294:BN140_RS03800
uniprot id: I7J7T5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1201294:BN140 RS11480
gene id: 1201294:BN140_RS11480
uniprot id: I7L139
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1201294:BN140 RS00460
gene id: 1201294:BN140_RS00460
uniprot id: I7KX93
names: Subcellular Location Annotation
messages: Cytoplasm

1201294:BN140 RS10835
gene id: 1201294:BN140_RS10835
uniprot id: I7JAE8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1201294:BN140 RS06495
gene id: 1201294:BN140_RS06495
uniprot id: I7KCS5
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS02355
gene id: 1201294:BN140_RS02355
uniprot id: I7J7G7
names: Similarity
messages: Belongs to the CutA family.

1201294:BN140 RS11375
gene id: 1201294:BN140_RS11375
uniprot id: I7JAL1
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1201294:BN140 RS12035
gene id: 1201294:BN140_RS12035
uniprot id: I7LNS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1201294:BN140 RS10035
gene id: 1201294:BN140_RS10035
uniprot id: I7L0M2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1201294:BN140 RS01525
gene id: 1201294:BN140_RS01525
uniprot id: I7J7A5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1201294:BN140 RS02595
gene id: 1201294:BN140_RS02595
uniprot id: I7LLJ8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1201294:BN140 RS09350
gene id: 1201294:BN140_RS09350
uniprot id: I7LN48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1201294:BN140 RS12340
gene id: 1201294:BN140_RS12340
uniprot id: I7LKX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1201294:BN140 RS06555
gene id: 1201294:BN140_RS06555
uniprot id: I7LJQ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS11995
gene id: 1201294:BN140_RS11995
uniprot id: I7KDZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1201294:BN140 RS10560
gene id: 1201294:BN140_RS10560
uniprot id: I7LKJ7
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1201294:BN140 RS03795
gene id: 1201294:BN140_RS03795
uniprot id: I7LJ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1201294:BN140 RS10135
gene id: 1201294:BN140_RS10135
uniprot id: I7JA54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1201294:BN140 RS10805
gene id: 1201294:BN140_RS10805
uniprot id: I7KDQ5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1201294:BN140 RS07320
gene id: 1201294:BN140_RS07320
uniprot id: I7KZP0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1201294:BN140 RS09730
gene id: 1201294:BN140_RS09730
uniprot id: I7LKC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1201294:BN140 RS00840
gene id: 1201294:BN140_RS00840
uniprot id: I7KAY2
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1201294:BN140 RS03080
gene id: 1201294:BN140_RS03080
uniprot id: I7KY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1201294:BN140 RS06065
gene id: 1201294:BN140_RS06065
uniprot id: I7LJN0
names: Similarity
messages: Belongs to the UPF0173 family.

1201294:BN140 RS00210
gene id: 1201294:BN140_RS00210
uniprot id: I7KAR8
names: Subcellular Location Annotation
messages: Membrane

1201294:BN140 RS12985
gene id: 1201294:BN140_RS12985
uniprot id: I7L1N5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1201294:BN140 RS11900
gene id: 1201294:BN140_RS11900
uniprot id: I7L197
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS10075
gene id: 1201294:BN140_RS10075
uniprot id: I7LNA1
names: Subcellular Location Annotation
messages: Cytoplasm

1201294:BN140 RS05020
gene id: 1201294:BN140_RS05020
uniprot id: I7J863
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1201294:BN140 RS00980
gene id: 1201294:BN140_RS00980
uniprot id: I7KAZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1201294:BN140 RS10095
gene id: 1201294:BN140_RS10095
uniprot id: I7L0N2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1201294:BN140 RS08625
gene id: 1201294:BN140_RS08625
uniprot id: I7LMZ3
names: Similarity
messages: Belongs to the HdrC family.

1201294:BN140 RS08360
gene id: 1201294:BN140_RS08360
uniprot id: I7LK41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

1201294:BN140 RS01495
gene id: 1201294:BN140_RS01495
uniprot id: I7LIR1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

1201294:BN140 RS06135
gene id: 1201294:BN140_RS06135
uniprot id: I7J8L1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1201294:BN140 RS04525
gene id: 1201294:BN140_RS04525
uniprot id: I7J813
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1201294:BN140 RS05660
gene id: 1201294:BN140_RS05660
uniprot id: I7J8F7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1201294:BN140 RS08560
gene id: 1201294:BN140_RS08560
uniprot id: I7LK54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1201294:BN140 RS02095
gene id: 1201294:BN140_RS02095
uniprot id: I7KBB7
names: Similarity
messages: Belongs to the serpin family.

1201294:BN140 RS06440
gene id: 1201294:BN140_RS06440
uniprot id: I7KZC6
names: Similarity
messages: Belongs to the UPF0200 family.

1201294:BN140 RS07435
gene id: 1201294:BN140_RS07435
uniprot id: I7LJX0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1201294:BN140 RS12880
gene id: 1201294:BN140_RS12880
uniprot id: I7KE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane