1200352:A606 RS10075
gene id: 1200352:A606_RS10075
uniprot id: S4XEP1
names: Similarity
messages: Belongs to the asp23 family.

1200352:A606 RS04120
gene id: 1200352:A606_RS04120
uniprot id: S4XIP2
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04795
gene id: 1200352:A606_RS04795
uniprot id: S4XFZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1200352:A606 RS00655
gene id: 1200352:A606_RS00655
uniprot id: S4XAY7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1200352:A606 RS02060
gene id: 1200352:A606_RS02060
uniprot id: S4XC61
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS11810
gene id: 1200352:A606_RS11810
uniprot id: S4XMR0
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04365
gene id: 1200352:A606_RS04365
uniprot id: S4XFT8
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1200352:A606 RS10245
gene id: 1200352:A606_RS10245
uniprot id: S4XES0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1200352:A606 RS03325
gene id: 1200352:A606_RS03325
uniprot id: S4XAZ4
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1200352:A606 RS06075
gene id: 1200352:A606_RS06075
uniprot id: S4XE49
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS09325
gene id: 1200352:A606_RS09325
uniprot id: S4XIF5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1200352:A606 RS09220
gene id: 1200352:A606_RS09220
uniprot id: S4XFU6
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1200352:A606 RS04415
gene id: 1200352:A606_RS04415
uniprot id: S4XDB5
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1200352:A606 RS00820
gene id: 1200352:A606_RS00820
uniprot id: S4XBG3
names: Similarity
messages: Belongs to the universal stress protein A family.

1200352:A606 RS06715
gene id: 1200352:A606_RS06715
uniprot id: S4XEH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1200352:A606 RS08060
gene id: 1200352:A606_RS08060
uniprot id: S4XDJ1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS01290
gene id: 1200352:A606_RS01290
uniprot id: S4XGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1200352:A606 RS11465
gene id: 1200352:A606_RS11465
uniprot id: S4XH12
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

1200352:A606 RS06010
gene id: 1200352:A606_RS06010
uniprot id: S4XCH1
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.

1200352:A606 RS03650
gene id: 1200352:A606_RS03650
uniprot id: S4XB63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1200352:A606 RS09565
gene id: 1200352:A606_RS09565
uniprot id: S4XII0
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1200352:A606 RS05755
gene id: 1200352:A606_RS05755
uniprot id: S4XCC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1200352:A606 RS01940
gene id: 1200352:A606_RS01940
uniprot id: S4XEK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1200352:A606 RS04880
gene id: 1200352:A606_RS04880
uniprot id: S4XBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1200352:A606 RS03465
gene id: 1200352:A606_RS03465
uniprot id: S4XFD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1200352:A606 RS10830
gene id: 1200352:A606_RS10830
uniprot id: S4XM91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS00285
gene id: 1200352:A606_RS00285
uniprot id: S4XB72
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS08755
gene id: 1200352:A606_RS08755
uniprot id: S4XL85
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1200352:A606 RS01785
gene id: 1200352:A606_RS01785
uniprot id: S4XC20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS02575
gene id: 1200352:A606_RS02575
uniprot id: S4XHP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1200352:A606 RS05000
gene id: 1200352:A606_RS05000
uniprot id: S4XDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1200352:A606 RS01520
gene id: 1200352:A606_RS01520
uniprot id: S4XBK2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS05525
gene id: 1200352:A606_RS05525
uniprot id: S4XDU7
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

1200352:A606 RS06215
gene id: 1200352:A606_RS06215
uniprot id: S4XGT0
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1200352:A606 RS04290
gene id: 1200352:A606_RS04290
uniprot id: S4XBK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS06445
gene id: 1200352:A606_RS06445
uniprot id: S4XEA9
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1200352:A606 RS10055
gene id: 1200352:A606_RS10055
uniprot id: S4XLW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1200352:A606 RS08035
gene id: 1200352:A606_RS08035
uniprot id: S4XDI6
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01220
gene id: 1200352:A606_RS01220
uniprot id: S4XBQ3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1200352:A606 RS11370
gene id: 1200352:A606_RS11370
uniprot id: S4XH33
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

1200352:A606 RS07235
gene id: 1200352:A606_RS07235
uniprot id: S4XKF7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1200352:A606 RS11560
gene id: 1200352:A606_RS11560
uniprot id: S4XH28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1200352:A606 RS02070
gene id: 1200352:A606_RS02070
uniprot id: S4XBV2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS11985
gene id: 1200352:A606_RS11985
uniprot id: S4XHI6
names: Similarity
messages: Belongs to the thioredoxin family.

1200352:A606 RS10325
gene id: 1200352:A606_RS10325
uniprot id: S4XM02
names: Subcellular Location Annotation
messages: Cell membrane

1200352:A606 RS04065
gene id: 1200352:A606_RS04065
uniprot id: S4XBG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS06290
gene id: 1200352:A606_RS06290
uniprot id: S4XGU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1200352:A606 RS10035
gene id: 1200352:A606_RS10035
uniprot id: S4XG97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1200352:A606 RS11340
gene id: 1200352:A606_RS11340
uniprot id: S4XJC7
names: Similarity
messages: Belongs to the allantoicase family.

1200352:A606 RS04635
gene id: 1200352:A606_RS04635
uniprot id: S4XIY2
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

1200352:A606 RS10490
gene id: 1200352:A606_RS10490
uniprot id: S4XEX5
names: Cofactor
messages: Can also use Mn(2+) ion.

1200352:A606 RS08940
gene id: 1200352:A606_RS08940
uniprot id: S4XFM9
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1200352:A606 RS05965
gene id: 1200352:A606_RS05965
uniprot id: S4XJR6
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

1200352:A606 RS10780
gene id: 1200352:A606_RS10780
uniprot id: S4XM82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1200352:A606 RS09930
gene id: 1200352:A606_RS09930
uniprot id: S4XEK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1200352:A606 RS07025
gene id: 1200352:A606_RS07025
uniprot id: S4XER0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1200352:A606 RS04790
gene id: 1200352:A606_RS04790
uniprot id: S4XDH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS01820
gene id: 1200352:A606_RS01820
uniprot id: S4XBQ8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS03405
gene id: 1200352:A606_RS03405
uniprot id: S4XI70
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

1200352:A606 RS08350
gene id: 1200352:A606_RS08350
uniprot id: S4XL15
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01485
gene id: 1200352:A606_RS01485
uniprot id: S4XBX0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1200352:A606 RS08775
gene id: 1200352:A606_RS08775
uniprot id: S4XFL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

1200352:A606 RS09710
gene id: 1200352:A606_RS09710
uniprot id: S4XLR8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1200352:A606 RS05995
gene id: 1200352:A606_RS05995
uniprot id: S4XE35
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1200352:A606 RS03060
gene id: 1200352:A606_RS03060
uniprot id: S4XCC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

1200352:A606 RS02540
gene id: 1200352:A606_RS02540
uniprot id: S4XC34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS07010
gene id: 1200352:A606_RS07010
uniprot id: S4XKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1200352:A606 RS06150
gene id: 1200352:A606_RS06150
uniprot id: S4XE65
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1200352:A606 RS08585
gene id: 1200352:A606_RS08585
uniprot id: S4XFG3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1200352:A606 RS07240
gene id: 1200352:A606_RS07240
uniprot id: S4XER9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1200352:A606 RS10540
gene id: 1200352:A606_RS10540
uniprot id: S4XGN6
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

1200352:A606 RS04255
gene id: 1200352:A606_RS04255
uniprot id: S4XFS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1200352:A606 RS04090
gene id: 1200352:A606_RS04090
uniprot id: S4XBH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS07790
gene id: 1200352:A606_RS07790
uniprot id: S4XF14
names: Similarity
messages: Belongs to the peptidase M17 family.

1200352:A606 RS07835
gene id: 1200352:A606_RS07835
uniprot id: S4XKQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MshB deacetylase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.

1200352:A606 RS05855
gene id: 1200352:A606_RS05855
uniprot id: S4XE09
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1200352:A606 RS05075
gene id: 1200352:A606_RS05075
uniprot id: S4XDL2
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1200352:A606 RS07165
gene id: 1200352:A606_RS07165
uniprot id: S4XEQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1200352:A606 RS05980
gene id: 1200352:A606_RS05980
uniprot id: S4XE32
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1200352:A606 RS03505
gene id: 1200352:A606_RS03505
uniprot id: S4XCL5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1200352:A606 RS06635
gene id: 1200352:A606_RS06635
uniprot id: S4XK59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS05275
gene id: 1200352:A606_RS05275
uniprot id: S4XDR6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS10295
gene id: 1200352:A606_RS10295
uniprot id: S4XET1
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS02550
gene id: 1200352:A606_RS02550
uniprot id: S4XHP1
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1200352:A606 RS00005
gene id: 1200352:A606_RS00005
uniprot id: S4XB20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1200352:A606 RS08525
gene id: 1200352:A606_RS08525
uniprot id: S4XL35
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1200352:A606 RS04330
gene id: 1200352:A606_RS04330
uniprot id: S4XFT4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS08210
gene id: 1200352:A606_RS08210
uniprot id: S4XDL8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04455
gene id: 1200352:A606_RS04455
uniprot id: S4XBN0
names: Similarity
messages: Belongs to the glutamine synthetase family.

1200352:A606 RS01150
gene id: 1200352:A606_RS01150
uniprot id: S4XE52
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

1200352:A606 RS08015
gene id: 1200352:A606_RS08015
uniprot id: S4XKT5
names: Similarity
messages: Belongs to the FBPase class 2 family.

1200352:A606 RS03640
gene id: 1200352:A606_RS03640
uniprot id: S4XFG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS11775
gene id: 1200352:A606_RS11775
uniprot id: S4XHD4
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS03695
gene id: 1200352:A606_RS03695
uniprot id: S4XCQ6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1200352:A606 RS07455
gene id: 1200352:A606_RS07455
uniprot id: S4XD70
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04235
gene id: 1200352:A606_RS04235
uniprot id: S4XD57
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1200352:A606 RS00260
gene id: 1200352:A606_RS00260
uniprot id: S4XGC4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1200352:A606 RS06030
gene id: 1200352:A606_RS06030
uniprot id: S4XGP3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1200352:A606 RS08615
gene id: 1200352:A606_RS08615
uniprot id: S4XI08
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS05355
gene id: 1200352:A606_RS05355
uniprot id: S4XJD4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1200352:A606 RS05480
gene id: 1200352:A606_RS05480
uniprot id: S4XC71
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS10410
gene id: 1200352:A606_RS10410
uniprot id: S4XGL1
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1200352:A606 RS01420
gene id: 1200352:A606_RS01420
uniprot id: S4XBG1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS03235
gene id: 1200352:A606_RS03235
uniprot id: S4XCP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

1200352:A606 RS03255
gene id: 1200352:A606_RS03255
uniprot id: S4XI40
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1200352:A606 RS05950
gene id: 1200352:A606_RS05950
uniprot id: S4XGN1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1200352:A606 RS04575
gene id: 1200352:A606_RS04575
uniprot id: S4XDB6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1200352:A606 RS04750
gene id: 1200352:A606_RS04750
uniprot id: S4XDF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1200352:A606 RS08870
gene id: 1200352:A606_RS08870
uniprot id: S4XI58
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1200352:A606 RS01610
gene id: 1200352:A606_RS01610
uniprot id: S4XBZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1200352:A606 RS11885
gene id: 1200352:A606_RS11885
uniprot id: S4XMS1
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS03775
gene id: 1200352:A606_RS03775
uniprot id: S4XB95
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS01405
gene id: 1200352:A606_RS01405
uniprot id: S4XH03
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1200352:A606 RS01840
gene id: 1200352:A606_RS01840
uniprot id: S4XEI6
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1200352:A606 RS11045
gene id: 1200352:A606_RS11045
uniprot id: S4XJ69
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS11390
gene id: 1200352:A606_RS11390
uniprot id: S4XJD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

1200352:A606 RS08140
gene id: 1200352:A606_RS08140
uniprot id: S4XKW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1200352:A606 RS10365
gene id: 1200352:A606_RS10365
uniprot id: S4XGJ9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1200352:A606 RS10045
gene id: 1200352:A606_RS10045
uniprot id: S4XGE0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1200352:A606 RS02175
gene id: 1200352:A606_RS02175
uniprot id: S4XHG0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1200352:A606 RS09430
gene id: 1200352:A606_RS09430
uniprot id: S4XIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1200352:A606 RS06210
gene id: 1200352:A606_RS06210
uniprot id: S4XE73
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01300
gene id: 1200352:A606_RS01300
uniprot id: S4XE82
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1200352:A606 RS00220
gene id: 1200352:A606_RS00220
uniprot id: S4XDN4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS09655
gene id: 1200352:A606_RS09655
uniprot id: S4XEF9
names: Similarity
messages: Belongs to the WXG100 family.

1200352:A606 RS07600
gene id: 1200352:A606_RS07600
uniprot id: S4XD99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1200352:A606 RS09405
gene id: 1200352:A606_RS09405
uniprot id: S4XIG6
names: Similarity
messages: Belongs to the peptidase C1 family.

1200352:A606 RS08270
gene id: 1200352:A606_RS08270
uniprot id: S4XKZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1200352:A606 RS08135
gene id: 1200352:A606_RS08135
uniprot id: S4XDK6
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1200352:A606 RS05770
gene id: 1200352:A606_RS05770
uniprot id: S4XDZ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1200352:A606 RS09775
gene id: 1200352:A606_RS09775
uniprot id: S4XG90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1200352:A606 RS10300
gene id: 1200352:A606_RS10300
uniprot id: S4XLZ9
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS10680
gene id: 1200352:A606_RS10680
uniprot id: S4XM59
names: Similarity
messages: Belongs to the GSP E family.

1200352:A606 RS11980
gene id: 1200352:A606_RS11980
uniprot id: S4XJQ8
names: Similarity
messages: Belongs to the PspA/IM30 family.

1200352:A606 RS08555
gene id: 1200352:A606_RS08555
uniprot id: S4XFF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS11930
gene id: 1200352:A606_RS11930
uniprot id: S4XJQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1200352:A606 RS06700
gene id: 1200352:A606_RS06700
uniprot id: S4XEJ7
names: Function
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.

1200352:A606 RS06510
gene id: 1200352:A606_RS06510
uniprot id: S4XCQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS10945
gene id: 1200352:A606_RS10945
uniprot id: S4XGW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1200352:A606 RS06560
gene id: 1200352:A606_RS06560
uniprot id: S4XK41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1200352:A606 RS08560
gene id: 1200352:A606_RS08560
uniprot id: S4XHZ8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS00980
gene id: 1200352:A606_RS00980
uniprot id: S4XB61
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

1200352:A606 RS07365
gene id: 1200352:A606_RS07365
uniprot id: S4XET9
names: Similarity
messages: Belongs to the EfeM/EfeO family.

1200352:A606 RS05420
gene id: 1200352:A606_RS05420
uniprot id: S4XGC6
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS11160
gene id: 1200352:A606_RS11160
uniprot id: S4XGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1200352:A606 RS05220
gene id: 1200352:A606_RS05220
uniprot id: S4XG89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1200352:A606 RS09410
gene id: 1200352:A606_RS09410
uniprot id: S4XG20
names: Subcellular Location Annotation
messages: Secreted

1200352:A606 RS12010
gene id: 1200352:A606_RS12010
uniprot id: S4XHJ0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1200352:A606 RS09765
gene id: 1200352:A606_RS09765
uniprot id: S4XG47
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1200352:A606 RS12005
gene id: 1200352:A606_RS12005
uniprot id: S4XJR1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1200352:A606 RS05650
gene id: 1200352:A606_RS05650
uniprot id: S4XDX2
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

1200352:A606 RS07045
gene id: 1200352:A606_RS07045
uniprot id: S4XH75
names: Similarity
messages: Belongs to the DprA/Smf family.

1200352:A606 RS11615
gene id: 1200352:A606_RS11615
uniprot id: S4XJI3
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1200352:A606 RS02915
gene id: 1200352:A606_RS02915
uniprot id: S4XHX0
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1200352:A606 RS07445
gene id: 1200352:A606_RS07445
uniprot id: S4XHD8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1200352:A606 RS03965
gene id: 1200352:A606_RS03965
uniprot id: S4XFM0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS03040
gene id: 1200352:A606_RS03040
uniprot id: S4XAT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1200352:A606 RS07115
gene id: 1200352:A606_RS07115
uniprot id: S4XEP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1200352:A606 RS00195
gene id: 1200352:A606_RS00195
uniprot id: S4XDN0
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1200352:A606 RS04835
gene id: 1200352:A606_RS04835
uniprot id: S4XJ23
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1200352:A606 RS10070
gene id: 1200352:A606_RS10070
uniprot id: S4XGE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1200352:A606 RS01740
gene id: 1200352:A606_RS01740
uniprot id: S4XEH1
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1200352:A606 RS07380
gene id: 1200352:A606_RS07380
uniprot id: S4XD56
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS05190
gene id: 1200352:A606_RS05190
uniprot id: S4XDQ2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

1200352:A606 RS09780
gene id: 1200352:A606_RS09780
uniprot id: S4XEI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1200352:A606 RS10630
gene id: 1200352:A606_RS10630
uniprot id: S4XM50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1200352:A606 RS01500
gene id: 1200352:A606_RS01500
uniprot id: S4XA16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1200352:A606 RS07860
gene id: 1200352:A606_RS07860
uniprot id: S4XKR2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS04610
gene id: 1200352:A606_RS04610
uniprot id: S4XIX6
names: Similarity
messages: Belongs to the asparagine synthetase family.

1200352:A606 RS03280
gene id: 1200352:A606_RS03280
uniprot id: S4XI46
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1200352:A606 RS02920
gene id: 1200352:A606_RS02920
uniprot id: S4XCI8
names: Subcellular Location Annotation
messages: Cell membrane

1200352:A606 RS01525
gene id: 1200352:A606_RS01525
uniprot id: S4XA19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1200352:A606 RS02515
gene id: 1200352:A606_RS02515
uniprot id: S4XEW1
names: Similarity
messages: Belongs to the citrate synthase family.

1200352:A606 RS07825
gene id: 1200352:A606_RS07825
uniprot id: S4XF51
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1200352:A606 RS01795
gene id: 1200352:A606_RS01795
uniprot id: S4XBQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1200352:A606 RS09925
gene id: 1200352:A606_RS09925
uniprot id: S4XGB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1200352:A606 RS00595
gene id: 1200352:A606_RS00595
uniprot id: S4XBD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1200352:A606 RS04405
gene id: 1200352:A606_RS04405
uniprot id: S4XBM1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS10870
gene id: 1200352:A606_RS10870
uniprot id: S4XGU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

1200352:A606 RS08220
gene id: 1200352:A606_RS08220
uniprot id: S4XF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS05465
gene id: 1200352:A606_RS05465
uniprot id: S4XDU8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1200352:A606 RS12370
gene id: 1200352:A606_RS12370
uniprot id: S4XH59
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS02490
gene id: 1200352:A606_RS02490
uniprot id: S4XEV7
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1200352:A606 RS02945
gene id: 1200352:A606_RS02945
uniprot id: S4XHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1200352:A606 RS10020
gene id: 1200352:A606_RS10020
uniprot id: S4XGD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1200352:A606 RS07015
gene id: 1200352:A606_RS07015
uniprot id: S4XEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1200352:A606 RS06545
gene id: 1200352:A606_RS06545
uniprot id: S4XGY7
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

1200352:A606 RS08530
gene id: 1200352:A606_RS08530
uniprot id: S4XFF2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1200352:A606 RS02740
gene id: 1200352:A606_RS02740
uniprot id: S4XC68
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1200352:A606 RS09745
gene id: 1200352:A606_RS09745
uniprot id: S4XIK2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1200352:A606 RS07700
gene id: 1200352:A606_RS07700
uniprot id: S4XF30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

1200352:A606 RS06155
gene id: 1200352:A606_RS06155
uniprot id: S4XGS0
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1200352:A606 RS11050
gene id: 1200352:A606_RS11050
uniprot id: S4XGY3
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04840
gene id: 1200352:A606_RS04840
uniprot id: S4XDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1200352:A606 RS07750
gene id: 1200352:A606_RS07750
uniprot id: S4XF38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1200352:A606 RS11735
gene id: 1200352:A606_RS11735
uniprot id: S4XMP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1200352:A606 RS00830
gene id: 1200352:A606_RS00830
uniprot id: S4XB22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1200352:A606 RS08960
gene id: 1200352:A606_RS08960
uniprot id: S4XLB7
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1200352:A606 RS06025
gene id: 1200352:A606_RS06025
uniprot id: S4XE40
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1200352:A606 RS03415
gene id: 1200352:A606_RS03415
uniprot id: S4XFC2
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1200352:A606 RS09380
gene id: 1200352:A606_RS09380
uniprot id: S4XIG1
names: Similarity
messages: Belongs to the peptidase M18 family.

1200352:A606 RS08495
gene id: 1200352:A606_RS08495
uniprot id: S4XDS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1200352:A606 RS05090
gene id: 1200352:A606_RS05090
uniprot id: S4XJ78
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1200352:A606 RS09955
gene id: 1200352:A606_RS09955
uniprot id: S4XLV6
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1200352:A606 RS05185
gene id: 1200352:A606_RS05185
uniprot id: S4XJ98
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1200352:A606 RS00900
gene id: 1200352:A606_RS00900
uniprot id: S4XE06
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1200352:A606 RS06775
gene id: 1200352:A606_RS06775
uniprot id: S4XEL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1200352:A606 RS02135
gene id: 1200352:A606_RS02135
uniprot id: S4XEP2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1200352:A606 RS06850
gene id: 1200352:A606_RS06850
uniprot id: S4XEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Mediates magnesium influx to the cytosol.

1200352:A606 RS05205
gene id: 1200352:A606_RS05205
uniprot id: S4XC17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1200352:A606 RS02845
gene id: 1200352:A606_RS02845
uniprot id: S4XCH7
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1200352:A606 RS01985
gene id: 1200352:A606_RS01985
uniprot id: S4XC49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1200352:A606 RS05425
gene id: 1200352:A606_RS05425
uniprot id: S4XDS8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS03050
gene id: 1200352:A606_RS03050
uniprot id: S4XCK9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1200352:A606 RS08675
gene id: 1200352:A606_RS08675
uniprot id: S4XDW0
names: Similarity
messages: Belongs to the CdaR family.

1200352:A606 RS03075
gene id: 1200352:A606_RS03075
uniprot id: S4XCL2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1200352:A606 RS09725
gene id: 1200352:A606_RS09725
uniprot id: S4XG80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1200352:A606 RS11215
gene id: 1200352:A606_RS11215
uniprot id: S4XJA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1200352:A606 RS08440
gene id: 1200352:A606_RS08440
uniprot id: S4XFG1
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).

1200352:A606 RS01765
gene id: 1200352:A606_RS01765
uniprot id: S4XEH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1200352:A606 RS05720
gene id: 1200352:A606_RS05720
uniprot id: S4XGI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1200352:A606 RS04975
gene id: 1200352:A606_RS04975
uniprot id: S4XDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1200352:A606 RS04805
gene id: 1200352:A606_RS04805
uniprot id: S4XBT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1200352:A606 RS04550
gene id: 1200352:A606_RS04550
uniprot id: S4XDB1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS07485
gene id: 1200352:A606_RS07485
uniprot id: S4XKJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1200352:A606 RS01980
gene id: 1200352:A606_RS01980
uniprot id: S4XHC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1200352:A606 RS08520
gene id: 1200352:A606_RS08520
uniprot id: S4XDT0
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1200352:A606 RS11720
gene id: 1200352:A606_RS11720
uniprot id: S4XJK3
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS00400
gene id: 1200352:A606_RS00400
uniprot id: S4X9E8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS05845
gene id: 1200352:A606_RS05845
uniprot id: S4XE10
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1200352:A606 RS07655
gene id: 1200352:A606_RS07655
uniprot id: S4XKM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1200352:A606 RS01390
gene id: 1200352:A606_RS01390
uniprot id: S4XE97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1200352:A606 RS07120
gene id: 1200352:A606_RS07120
uniprot id: S4XH89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS07390
gene id: 1200352:A606_RS07390
uniprot id: S4XEU2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS11490
gene id: 1200352:A606_RS11490
uniprot id: S4XH16
names: Similarity
messages: Belongs to the group II decarboxylase family.

1200352:A606 RS02560
gene id: 1200352:A606_RS02560
uniprot id: S4XEX1
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS10750
gene id: 1200352:A606_RS10750
uniprot id: S4XM79
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1200352:A606 RS10040
gene id: 1200352:A606_RS10040
uniprot id: S4XIN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1200352:A606 RS01415
gene id: 1200352:A606_RS01415
uniprot id: S4XEA2
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS08320
gene id: 1200352:A606_RS08320
uniprot id: S4XDN9
names: Similarity
messages: Belongs to the isochorismate synthase family.

1200352:A606 RS02410
gene id: 1200352:A606_RS02410
uniprot id: S4XCB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1200352:A606 RS02025
gene id: 1200352:A606_RS02025
uniprot id: S4XA98
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1200352:A606 RS01035
gene id: 1200352:A606_RS01035
uniprot id: S4X9R3
names: Similarity
messages: Belongs to the mycobacterial A85 antigen family.

1200352:A606 RS00075
gene id: 1200352:A606_RS00075
uniprot id: S4XG88
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1200352:A606 RS03705
gene id: 1200352:A606_RS03705
uniprot id: S4XIC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1200352:A606 RS01100
gene id: 1200352:A606_RS01100
uniprot id: S4XE41
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1200352:A606 RS07585
gene id: 1200352:A606_RS07585
uniprot id: S4XEX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1200352:A606 RS02705
gene id: 1200352:A606_RS02705
uniprot id: S4XHS9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1200352:A606 RS08910
gene id: 1200352:A606_RS08910
uniprot id: S4XLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1200352:A606 RS10165
gene id: 1200352:A606_RS10165
uniprot id: S4XIQ6
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1200352:A606 RS10955
gene id: 1200352:A606_RS10955
uniprot id: S4XMB9
names: Similarity
messages: Belongs to the AccD/PCCB family.

1200352:A606 RS03110
gene id: 1200352:A606_RS03110
uniprot id: S4XCD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1200352:A606 RS05175
gene id: 1200352:A606_RS05175
uniprot id: S4XDN3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1200352:A606 RS03115
gene id: 1200352:A606_RS03115
uniprot id: S4XAU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1200352:A606 RS10110
gene id: 1200352:A606_RS10110
uniprot id: S4XGB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1200352:A606 RS10910
gene id: 1200352:A606_RS10910
uniprot id: S4XGR3
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1200352:A606 RS07810
gene id: 1200352:A606_RS07810
uniprot id: S4XKQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1200352:A606 RS08550
gene id: 1200352:A606_RS08550
uniprot id: S4XL40
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS06650
gene id: 1200352:A606_RS06650
uniprot id: S4XEH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1200352:A606 RS08105
gene id: 1200352:A606_RS08105
uniprot id: S4XFA2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1200352:A606 RS08480
gene id: 1200352:A606_RS08480
uniprot id: S4XFE4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1200352:A606 RS04260
gene id: 1200352:A606_RS04260
uniprot id: S4XD59
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04590
gene id: 1200352:A606_RS04590
uniprot id: S4XDE3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1200352:A606 RS00785
gene id: 1200352:A606_RS00785
uniprot id: S4XB15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 85 family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS10815
gene id: 1200352:A606_RS10815
uniprot id: S4XJ24
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1200352:A606 RS08250
gene id: 1200352:A606_RS08250
uniprot id: S4XFA0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1200352:A606 RS10200
gene id: 1200352:A606_RS10200
uniprot id: S4XLY5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1200352:A606 RS05440
gene id: 1200352:A606_RS05440
uniprot id: S4XDU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1200352:A606 RS03210
gene id: 1200352:A606_RS03210
uniprot id: S4XCN5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS12140
gene id: 1200352:A606_RS12140
uniprot id: S4XFW6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1200352:A606 RS10460
gene id: 1200352:A606_RS10460
uniprot id: S4XGL9
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1200352:A606 RS05385
gene id: 1200352:A606_RS05385
uniprot id: S4XJE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1200352:A606 RS06930
gene id: 1200352:A606_RS06930
uniprot id: S4XCZ7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1200352:A606 RS01355
gene id: 1200352:A606_RS01355
uniprot id: S4XGZ3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1200352:A606 RS06745
gene id: 1200352:A606_RS06745
uniprot id: S4XH34
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1200352:A606 RS05285
gene id: 1200352:A606_RS05285
uniprot id: S4XDQ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1200352:A606 RS08075
gene id: 1200352:A606_RS08075
uniprot id: S4XHR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS09145
gene id: 1200352:A606_RS09145
uniprot id: S4XFR9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1200352:A606 RS04475
gene id: 1200352:A606_RS04475
uniprot id: S4XD97
names: Similarity
messages: Belongs to the heme oxygenase family.

1200352:A606 RS08505
gene id: 1200352:A606_RS08505
uniprot id: S4XFE8
names: Similarity
messages: Belongs to the peptidase S1C family.

1200352:A606 RS01935
gene id: 1200352:A606_RS01935
uniprot id: S4XC41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1200352:A606 RS06695
gene id: 1200352:A606_RS06695
uniprot id: S4XH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1200352:A606 RS10115
gene id: 1200352:A606_RS10115
uniprot id: S4XIQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1200352:A606 RS06710
gene id: 1200352:A606_RS06710
uniprot id: S4XK80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1200352:A606 RS10240
gene id: 1200352:A606_RS10240
uniprot id: S4XGH7
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS00895
gene id: 1200352:A606_RS00895
uniprot id: S4XBH7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1200352:A606 RS03315
gene id: 1200352:A606_RS03315
uniprot id: S4XFA4
names: Similarity
messages: Belongs to the peptidase S58 family.

1200352:A606 RS04700
gene id: 1200352:A606_RS04700
uniprot id: S4XDD9
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

1200352:A606 RS09770
gene id: 1200352:A606_RS09770
uniprot id: S4XIK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1200352:A606 RS02495
gene id: 1200352:A606_RS02495
uniprot id: S4XC25
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS03530
gene id: 1200352:A606_RS03530
uniprot id: S4XCM0
names: Similarity
messages: Belongs to the peptidase M1 family.

1200352:A606 RS06540
gene id: 1200352:A606_RS06540
uniprot id: S4XEC9
names: Subcellular Location Annotation
messages: Cytoplasm

1200352:A606 RS09715
gene id: 1200352:A606_RS09715
uniprot id: S4XG35
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1200352:A606 RS05030
gene id: 1200352:A606_RS05030
uniprot id: S4XBY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1200352:A606 RS03320
gene id: 1200352:A606_RS03320
uniprot id: S4XCI0
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS07660
gene id: 1200352:A606_RS07660
uniprot id: S4XEZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1200352:A606 RS11830
gene id: 1200352:A606_RS11830
uniprot id: S4XFQ8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS08165
gene id: 1200352:A606_RS08165
uniprot id: S4XKW8
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1200352:A606 RS04535
gene id: 1200352:A606_RS04535
uniprot id: S4XIV9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS08345
gene id: 1200352:A606_RS08345
uniprot id: S4XDP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1200352:A606 RS10495
gene id: 1200352:A606_RS10495
uniprot id: S4XM33
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1200352:A606 RS00330
gene id: 1200352:A606_RS00330
uniprot id: S4XDQ1
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01870
gene id: 1200352:A606_RS01870
uniprot id: S4XBR5
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1200352:A606 RS01140
gene id: 1200352:A606_RS01140
uniprot id: S4XGU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1200352:A606 RS06240
gene id: 1200352:A606_RS06240
uniprot id: S4XGT5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1200352:A606 RS05655
gene id: 1200352:A606_RS05655
uniprot id: S4XCA3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

1200352:A606 RS05795
gene id: 1200352:A606_RS05795
uniprot id: S4XE04
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1200352:A606 RS02595
gene id: 1200352:A606_RS02595
uniprot id: S4XAJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1200352:A606 RS03070
gene id: 1200352:A606_RS03070
uniprot id: S4XI05
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1200352:A606 RS11650
gene id: 1200352:A606_RS11650
uniprot id: S4XH90
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1200352:A606 RS06430
gene id: 1200352:A606_RS06430
uniprot id: S4XEB3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1200352:A606 RS08025
gene id: 1200352:A606_RS08025
uniprot id: S4XHQ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1200352:A606 RS11575
gene id: 1200352:A606_RS11575
uniprot id: S4XFJ5
names: Similarity
messages: Belongs to the CsoR family.

1200352:A606 RS11265
gene id: 1200352:A606_RS11265
uniprot id: S4XJB2
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS02520
gene id: 1200352:A606_RS02520
uniprot id: S4XC30
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

1200352:A606 RS09370
gene id: 1200352:A606_RS09370
uniprot id: S4XLM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1200352:A606 RS08760
gene id: 1200352:A606_RS08760
uniprot id: S4XFJ8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1200352:A606 RS04540
gene id: 1200352:A606_RS04540
uniprot id: S4XDD6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS06250
gene id: 1200352:A606_RS06250
uniprot id: S4XCL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS02200
gene id: 1200352:A606_RS02200
uniprot id: S4XHG4
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1200352:A606 RS03710
gene id: 1200352:A606_RS03710
uniprot id: S4XCW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS04695
gene id: 1200352:A606_RS04695
uniprot id: S4XFY1
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

1200352:A606 RS04005
gene id: 1200352:A606_RS04005
uniprot id: S4XIJ9
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1200352:A606 RS07645
gene id: 1200352:A606_RS07645
uniprot id: S4XF21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1200352:A606 RS03250
gene id: 1200352:A606_RS03250
uniprot id: S4XAX8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS02615
gene id: 1200352:A606_RS02615
uniprot id: S4XC50
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

1200352:A606 RS08875
gene id: 1200352:A606_RS08875
uniprot id: S4XFN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1200352:A606 RS03085
gene id: 1200352:A606_RS03085
uniprot id: S4XCD4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1200352:A606 RS10005
gene id: 1200352:A606_RS10005
uniprot id: S4XLW0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.

1200352:A606 RS05940
gene id: 1200352:A606_RS05940
uniprot id: S4XJR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1200352:A606 RS10285
gene id: 1200352:A606_RS10285
uniprot id: S4XIS4
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.

1200352:A606 RS08965
gene id: 1200352:A606_RS08965
uniprot id: S4XFN2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1200352:A606 RS07815
gene id: 1200352:A606_RS07815
uniprot id: S4XF20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

1200352:A606 RS08290
gene id: 1200352:A606_RS08290
uniprot id: S4XFD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1200352:A606 RS04655
gene id: 1200352:A606_RS04655
uniprot id: S4XBR3
names: Similarity
messages: Belongs to the peptidase C40 family.

1200352:A606 RS07530
gene id: 1200352:A606_RS07530
uniprot id: S4XD84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1200352:A606 RS05155
gene id: 1200352:A606_RS05155
uniprot id: S4XC08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1200352:A606 RS12035
gene id: 1200352:A606_RS12035
uniprot id: S4XHJ5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1200352:A606 RS06245
gene id: 1200352:A606_RS06245
uniprot id: S4XE84
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1200352:A606 RS00015
gene id: 1200352:A606_RS00015
uniprot id: S4XAK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1200352:A606 RS07845
gene id: 1200352:A606_RS07845
uniprot id: S4XHL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1200352:A606 RS04380
gene id: 1200352:A606_RS04380
uniprot id: S4XIT3
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1200352:A606 RS04745
gene id: 1200352:A606_RS04745
uniprot id: S4XFY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1200352:A606 RS08260
gene id: 1200352:A606_RS08260
uniprot id: S4XFC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS02785
gene id: 1200352:A606_RS02785
uniprot id: S4XAM8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS10975
gene id: 1200352:A606_RS10975
uniprot id: S4XF74
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1200352:A606 RS10065
gene id: 1200352:A606_RS10065
uniprot id: S4XIP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1200352:A606 RS05970
gene id: 1200352:A606_RS05970
uniprot id: S4XE30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1200352:A606 RS09485
gene id: 1200352:A606_RS09485
uniprot id: S4XG34
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1200352:A606 RS04965
gene id: 1200352:A606_RS04965
uniprot id: S4XDK9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1200352:A606 RS09990
gene id: 1200352:A606_RS09990
uniprot id: S4XIN3
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

1200352:A606 RS03270
gene id: 1200352:A606_RS03270
uniprot id: S4XCH0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

1200352:A606 RS04660
gene id: 1200352:A606_RS04660
uniprot id: S4XIY7
names: Similarity
messages: Belongs to the peptidase C40 family.

1200352:A606 RS07345
gene id: 1200352:A606_RS07345
uniprot id: S4XHC2
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

1200352:A606 RS11580
gene id: 1200352:A606_RS11580
uniprot id: S4XML4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1200352:A606 RS07535
gene id: 1200352:A606_RS07535
uniprot id: S4XKK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1200352:A606 RS05195
gene id: 1200352:A606_RS05195
uniprot id: S4XG83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1200352:A606 RS10720
gene id: 1200352:A606_RS10720
uniprot id: S4XGR8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1200352:A606 RS07180
gene id: 1200352:A606_RS07180
uniprot id: S4XD29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1200352:A606 RS12015
gene id: 1200352:A606_RS12015
uniprot id: S4XFU0
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS00965
gene id: 1200352:A606_RS00965
uniprot id: S4XGR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1200352:A606 RS09755
gene id: 1200352:A606_RS09755
uniprot id: S4XEH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1200352:A606 RS07475
gene id: 1200352:A606_RS07475
uniprot id: S4XEY8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1200352:A606 RS05505
gene id: 1200352:A606_RS05505
uniprot id: S4XC76
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1200352:A606 RS06730
gene id: 1200352:A606_RS06730
uniprot id: S4XCX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1200352:A606 RS08160
gene id: 1200352:A606_RS08160
uniprot id: S4XDL1
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1200352:A606 RS11710
gene id: 1200352:A606_RS11710
uniprot id: S4XMN6
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS02735
gene id: 1200352:A606_RS02735
uniprot id: S4XF01
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1200352:A606 RS06965
gene id: 1200352:A606_RS06965
uniprot id: S4XEL7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS00870
gene id: 1200352:A606_RS00870
uniprot id: S4XBH3
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

1200352:A606 RS12170
gene id: 1200352:A606_RS12170
uniprot id: S4XMX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1200352:A606 RS04980
gene id: 1200352:A606_RS04980
uniprot id: S4XBX3
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01655
gene id: 1200352:A606_RS01655
uniprot id: S4XH64
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS05715
gene id: 1200352:A606_RS05715
uniprot id: S4XDY9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1200352:A606 RS03615
gene id: 1200352:A606_RS03615
uniprot id: S4XFF5
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1200352:A606 RS03690
gene id: 1200352:A606_RS03690
uniprot id: S4XFG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1200352:A606 RS12145
gene id: 1200352:A606_RS12145
uniprot id: S4XMX2
names: Similarity
messages: Belongs to the thioredoxin family.

1200352:A606 RS07370
gene id: 1200352:A606_RS07370
uniprot id: S4XHC6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

1200352:A606 RS02065
gene id: 1200352:A606_RS02065
uniprot id: S4XEM7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS06770
gene id: 1200352:A606_RS06770
uniprot id: S4XH36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1200352:A606 RS09005
gene id: 1200352:A606_RS09005
uniprot id: S4XE28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

1200352:A606 RS05515
gene id: 1200352:A606_RS05515
uniprot id: S4XDV6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1200352:A606 RS07595
gene id: 1200352:A606_RS07595
uniprot id: S4XF10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1200352:A606 RS08715
gene id: 1200352:A606_RS08715
uniprot id: S4XI28
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1200352:A606 RS01265
gene id: 1200352:A606_RS01265
uniprot id: S4XGX7
names: Similarity
messages: Belongs to the universal stress protein A family.

1200352:A606 RS05200
gene id: 1200352:A606_RS05200
uniprot id: S4XDP0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1200352:A606 RS09865
gene id: 1200352:A606_RS09865
uniprot id: S4XG65
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1200352:A606 RS06310
gene id: 1200352:A606_RS06310
uniprot id: S4XE90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1200352:A606 RS09515
gene id: 1200352:A606_RS09515
uniprot id: S4XED8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1200352:A606 RS07570
gene id: 1200352:A606_RS07570
uniprot id: S4XF04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1200352:A606 RS09750
gene id: 1200352:A606_RS09750
uniprot id: S4XG85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1200352:A606 RS08915
gene id: 1200352:A606_RS08915
uniprot id: S4XFM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1200352:A606 RS01095
gene id: 1200352:A606_RS01095
uniprot id: S4XBM3
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01910
gene id: 1200352:A606_RS01910
uniprot id: S4XC39
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS10890
gene id: 1200352:A606_RS10890
uniprot id: S4XJ38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1200352:A606 RS04570
gene id: 1200352:A606_RS04570
uniprot id: S4XFW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1200352:A606 RS10795
gene id: 1200352:A606_RS10795
uniprot id: S4XGT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS08430
gene id: 1200352:A606_RS08430
uniprot id: S4XFD4
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1200352:A606 RS05915
gene id: 1200352:A606_RS05915
uniprot id: S4XJQ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS06230
gene id: 1200352:A606_RS06230
uniprot id: S4XJX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS04770
gene id: 1200352:A606_RS04770
uniprot id: S4XFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1200352:A606 RS05215
gene id: 1200352:A606_RS05215
uniprot id: S4XDQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1200352:A606 RS01530
gene id: 1200352:A606_RS01530
uniprot id: S4XH43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1200352:A606 RS08925
gene id: 1200352:A606_RS08925
uniprot id: S4XFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

1200352:A606 RS00735
gene id: 1200352:A606_RS00735
uniprot id: S4XB06
names: Similarity
messages: Belongs to the glutamate synthase family.

1200352:A606 RS08455
gene id: 1200352:A606_RS08455
uniprot id: S4XFD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

1200352:A606 RS09785
gene id: 1200352:A606_RS09785
uniprot id: S4XLT3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS06600
gene id: 1200352:A606_RS06600
uniprot id: S4XEF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS02460
gene id: 1200352:A606_RS02460
uniprot id: S4XCC1
names: Similarity
messages: Belongs to the GARS family.

1200352:A606 RS06300
gene id: 1200352:A606_RS06300
uniprot id: S4XCL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1200352:A606 RS11535
gene id: 1200352:A606_RS11535
uniprot id: S4XEN2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1200352:A606 RS11335
gene id: 1200352:A606_RS11335
uniprot id: S4XGZ0
names: Subunit
messages: Homotetramer.

1200352:A606 RS01055
gene id: 1200352:A606_RS01055
uniprot id: S4XB80
names: Similarity
messages: Belongs to the AccD/PCCB family.

1200352:A606 RS08515
gene id: 1200352:A606_RS08515
uniprot id: S4XFH5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1200352:A606 RS11400
gene id: 1200352:A606_RS11400
uniprot id: S4XFF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

1200352:A606 RS09310
gene id: 1200352:A606_RS09310
uniprot id: S4XEA7
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1200352:A606 RS08945
gene id: 1200352:A606_RS08945
uniprot id: S4XI74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1200352:A606 RS08540
gene id: 1200352:A606_RS08540
uniprot id: S4XFI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1200352:A606 RS00135
gene id: 1200352:A606_RS00135
uniprot id: S4XG98
names: Similarity
messages: Belongs to the TfdA dioxygenase family.

1200352:A606 RS05670
gene id: 1200352:A606_RS05670
uniprot id: S4XGH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1200352:A606 RS07415
gene id: 1200352:A606_RS07415
uniprot id: S4XEU7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS09540
gene id: 1200352:A606_RS09540
uniprot id: S4XIH9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS07755
gene id: 1200352:A606_RS07755
uniprot id: S4XDC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1200352:A606 RS00115
gene id: 1200352:A606_RS00115
uniprot id: S4XB42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1200352:A606 RS03020
gene id: 1200352:A606_RS03020
uniprot id: S4XHZ5
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS02690
gene id: 1200352:A606_RS02690
uniprot id: S4XEZ7
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

1200352:A606 RS04580
gene id: 1200352:A606_RS04580
uniprot id: S4XBQ0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1200352:A606 RS02120
gene id: 1200352:A606_RS02120
uniprot id: S4XAB2
names: Similarity
messages: Belongs to the Nth/MutY family.

1200352:A606 RS09845
gene id: 1200352:A606_RS09845
uniprot id: S4XIL4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1200352:A606 RS09415
gene id: 1200352:A606_RS09415
uniprot id: S4XEC1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1200352:A606 RS03595
gene id: 1200352:A606_RS03595
uniprot id: S4XCN2
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1200352:A606 RS02485
gene id: 1200352:A606_RS02485
uniprot id: S4XCC5
names: Subcellular Location Annotation
messages: Cell membrane

1200352:A606 RS05740
gene id: 1200352:A606_RS05740
uniprot id: S4XDZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1200352:A606 RS01705
gene id: 1200352:A606_RS01705
uniprot id: S4XH72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1200352:A606 RS08365
gene id: 1200352:A606_RS08365
uniprot id: S4XFE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1200352:A606 RS11470
gene id: 1200352:A606_RS11470
uniprot id: S4XJF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1200352:A606 RS06535
gene id: 1200352:A606_RS06535
uniprot id: S4XK35
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1200352:A606 RS05240
gene id: 1200352:A606_RS05240
uniprot id: S4XDR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS06670
gene id: 1200352:A606_RS06670
uniprot id: S4XH22
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS05925
gene id: 1200352:A606_RS05925
uniprot id: S4XGM7
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1200352:A606 RS00490
gene id: 1200352:A606_RS00490
uniprot id: S4XGH0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1200352:A606 RS02965
gene id: 1200352:A606_RS02965
uniprot id: S4XAR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS07560
gene id: 1200352:A606_RS07560
uniprot id: S4XEX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1200352:A606 RS03845
gene id: 1200352:A606_RS03845
uniprot id: S4XCT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1200352:A606 RS09510
gene id: 1200352:A606_RS09510
uniprot id: S4XG39
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1200352:A606 RS07800
gene id: 1200352:A606_RS07800
uniprot id: S4XF48
names: Similarity
messages: Belongs to the LOG family.

1200352:A606 RS06330
gene id: 1200352:A606_RS06330
uniprot id: S4XJZ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1200352:A606 RS12055
gene id: 1200352:A606_RS12055
uniprot id: S4XJR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS02405
gene id: 1200352:A606_RS02405
uniprot id: S4XHK7
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1200352:A606 RS10025
gene id: 1200352:A606_RS10025
uniprot id: S4XEM9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1200352:A606 RS03450
gene id: 1200352:A606_RS03450
uniprot id: S4XB23
names: Subcellular Location Annotation
messages: Cell membrane

1200352:A606 RS07160
gene id: 1200352:A606_RS07160
uniprot id: S4XKE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1200352:A606 RS04990
gene id: 1200352:A606_RS04990
uniprot id: S4XDL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1200352:A606 RS09575
gene id: 1200352:A606_RS09575
uniprot id: S4XEE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1200352:A606 RS11460
gene id: 1200352:A606_RS11460
uniprot id: S4XMJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS10060
gene id: 1200352:A606_RS10060
uniprot id: S4XGA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1200352:A606 RS03335
gene id: 1200352:A606_RS03335
uniprot id: S4XCQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1200352:A606 RS00985
gene id: 1200352:A606_RS00985
uniprot id: S4X9Q6
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1200352:A606 RS10840
gene id: 1200352:A606_RS10840
uniprot id: S4XJ28
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1200352:A606 RS06295
gene id: 1200352:A606_RS06295
uniprot id: S4XE94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1200352:A606 RS07425
gene id: 1200352:A606_RS07425
uniprot id: S4XEX8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04420
gene id: 1200352:A606_RS04420
uniprot id: S4XFU5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1200352:A606 RS01685
gene id: 1200352:A606_RS01685
uniprot id: S4XC05
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1200352:A606 RS07400
gene id: 1200352:A606_RS07400
uniprot id: S4XEX4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1200352:A606 RS07775
gene id: 1200352:A606_RS07775
uniprot id: S4XF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS11480
gene id: 1200352:A606_RS11480
uniprot id: S4XFH2
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1200352:A606 RS04720
gene id: 1200352:A606_RS04720
uniprot id: S4XFY6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1200352:A606 RS09440
gene id: 1200352:A606_RS09440
uniprot id: S4XEC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1200352:A606 RS07155
gene id: 1200352:A606_RS07155
uniprot id: S4XD26
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS05635
gene id: 1200352:A606_RS05635
uniprot id: S4XJJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1200352:A606 RS08535
gene id: 1200352:A606_RS08535
uniprot id: S4XHZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1200352:A606 RS06195
gene id: 1200352:A606_RS06195
uniprot id: S4XE75
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1200352:A606 RS05930
gene id: 1200352:A606_RS05930
uniprot id: S4XE21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1200352:A606 RS07000
gene id: 1200352:A606_RS07000
uniprot id: S4XEQ4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1200352:A606 RS01075
gene id: 1200352:A606_RS01075
uniprot id: S4XE36
names: Similarity
messages: Belongs to the oxoprolinase family.

1200352:A606 RS08005
gene id: 1200352:A606_RS08005
uniprot id: S4XF83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1200352:A606 RS07305
gene id: 1200352:A606_RS07305
uniprot id: S4XD45
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS05105
gene id: 1200352:A606_RS05105
uniprot id: S4XBZ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS06425
gene id: 1200352:A606_RS06425
uniprot id: S4XGW3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1200352:A606 RS02640
gene id: 1200352:A606_RS02640
uniprot id: S4XC54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1200352:A606 RS02170
gene id: 1200352:A606_RS02170
uniprot id: S4XAB9
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS06265
gene id: 1200352:A606_RS06265
uniprot id: S4XGU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1200352:A606 RS10340
gene id: 1200352:A606_RS10340
uniprot id: S4XGJ4
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1200352:A606 RS02570
gene id: 1200352:A606_RS02570
uniprot id: S4XAJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1200352:A606 RS02695
gene id: 1200352:A606_RS02695
uniprot id: S4XC63
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1200352:A606 RS06085
gene id: 1200352:A606_RS06085
uniprot id: S4XE54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1200352:A606 RS03275
gene id: 1200352:A606_RS03275
uniprot id: S4XAY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1200352:A606 RS09570
gene id: 1200352:A606_RS09570
uniprot id: S4XG49
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1200352:A606 RS05280
gene id: 1200352:A606_RS05280
uniprot id: S4XG99
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1200352:A606 RS10705
gene id: 1200352:A606_RS10705
uniprot id: S4XM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Membrane

1200352:A606 RS03750
gene id: 1200352:A606_RS03750
uniprot id: S4XB89
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS00280
gene id: 1200352:A606_RS00280
uniprot id: S4XGC9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1200352:A606 RS00880
gene id: 1200352:A606_RS00880
uniprot id: S4XB34
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS05315
gene id: 1200352:A606_RS05315
uniprot id: S4XC37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1200352:A606 RS04785
gene id: 1200352:A606_RS04785
uniprot id: S4XJ12
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS07990
gene id: 1200352:A606_RS07990
uniprot id: S4XKS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1200352:A606 RS07965
gene id: 1200352:A606_RS07965
uniprot id: S4XEN2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1200352:A606 RS02630
gene id: 1200352:A606_RS02630
uniprot id: S4XCE9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1200352:A606 RS07980
gene id: 1200352:A606_RS07980
uniprot id: S4XF80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1200352:A606 RS04555
gene id: 1200352:A606_RS04555
uniprot id: S4XBP6
names: Similarity
messages: Belongs to the glutamine synthetase family.

1200352:A606 RS01535
gene id: 1200352:A606_RS01535
uniprot id: S4XBY5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1200352:A606 RS06735
gene id: 1200352:A606_RS06735
uniprot id: S4XK82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1200352:A606 RS02675
gene id: 1200352:A606_RS02675
uniprot id: S4XHS3
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1200352:A606 RS03030
gene id: 1200352:A606_RS03030
uniprot id: S4XF52
names: Similarity
messages: Belongs to the FPG family.

1200352:A606 RS06515
gene id: 1200352:A606_RS06515
uniprot id: S4XK27
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

1200352:A606 RS06645
gene id: 1200352:A606_RS06645
uniprot id: S4XH13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1200352:A606 RS06305
gene id: 1200352:A606_RS06305
uniprot id: S4XJY4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1200352:A606 RS02090
gene id: 1200352:A606_RS02090
uniprot id: S4XEN2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1200352:A606 RS09730
gene id: 1200352:A606_RS09730
uniprot id: S4XEH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1200352:A606 RS06275
gene id: 1200352:A606_RS06275
uniprot id: S4XCL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1200352:A606 RS09910
gene id: 1200352:A606_RS09910
uniprot id: S4XLV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1200352:A606 RS07710
gene id: 1200352:A606_RS07710
uniprot id: S4XKN4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1200352:A606 RS03730
gene id: 1200352:A606_RS03730
uniprot id: S4XID4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1200352:A606 RS08450
gene id: 1200352:A606_RS08450
uniprot id: S4XL23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1200352:A606 RS02125
gene id: 1200352:A606_RS02125
uniprot id: S4XHF0
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
messages: Reversible hydration of carbon dioxide.

1200352:A606 RS10160
gene id: 1200352:A606_RS10160
uniprot id: S4XGC1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1200352:A606 RS05905
gene id: 1200352:A606_RS05905
uniprot id: S4XE17
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1200352:A606 RS07580
gene id: 1200352:A606_RS07580
uniprot id: S4XKL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1200352:A606 RS08840
gene id: 1200352:A606_RS08840
uniprot id: S4XFL0
names: Similarity
messages: Belongs to the DEAD box helicase family.

1200352:A606 RS09735
gene id: 1200352:A606_RS09735
uniprot id: S4XLS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1200352:A606 RS07110
gene id: 1200352:A606_RS07110
uniprot id: S4XKD8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1200352:A606 RS09155
gene id: 1200352:A606_RS09155
uniprot id: S4XFV1
names: Similarity
messages: Belongs to the peptidase C40 family.

1200352:A606 RS10735
gene id: 1200352:A606_RS10735
uniprot id: S4XGM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1200352:A606 RS10645
gene id: 1200352:A606_RS10645
uniprot id: S4XGQ3
names: Subcellular Location Annotation
messages: Cytoplasm

1200352:A606 RS12110
gene id: 1200352:A606_RS12110
uniprot id: S4XHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1200352:A606 RS11325
gene id: 1200352:A606_RS11325
uniprot id: S4XFE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1200352:A606 RS06785
gene id: 1200352:A606_RS06785
uniprot id: S4XK88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1200352:A606 RS09330
gene id: 1200352:A606_RS09330
uniprot id: S4XG06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1200352:A606 RS06035
gene id: 1200352:A606_RS06035
uniprot id: S4XE43
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1200352:A606 RS09355
gene id: 1200352:A606_RS09355
uniprot id: S4XIF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

1200352:A606 RS03480
gene id: 1200352:A606_RS03480
uniprot id: S4XB28
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01915
gene id: 1200352:A606_RS01915
uniprot id: S4XEK0
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS01385
gene id: 1200352:A606_RS01385
uniprot id: S4XBU0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1200352:A606 RS05460
gene id: 1200352:A606_RS05460
uniprot id: S4XJF6
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1200352:A606 RS02040
gene id: 1200352:A606_RS02040
uniprot id: S4XEM3
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS04450
gene id: 1200352:A606_RS04450
uniprot id: S4XD90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1200352:A606 RS10280
gene id: 1200352:A606_RS10280
uniprot id: S4XGE2
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1200352:A606 RS08335
gene id: 1200352:A606_RS08335
uniprot id: S4XHV7
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS09315
gene id: 1200352:A606_RS09315
uniprot id: S4XLM2
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1200352:A606 RS11510
gene id: 1200352:A606_RS11510
uniprot id: S4XMK2
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS03880
gene id: 1200352:A606_RS03880
uniprot id: S4XIH1
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS10550
gene id: 1200352:A606_RS10550
uniprot id: S4XM41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1200352:A606 RS05305
gene id: 1200352:A606_RS05305
uniprot id: S4XGA4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS10050
gene id: 1200352:A606_RS10050
uniprot id: S4XEN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1200352:A606 RS06990
gene id: 1200352:A606_RS06990
uniprot id: S4XEM2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS11740
gene id: 1200352:A606_RS11740
uniprot id: S4XH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

1200352:A606 RS01565
gene id: 1200352:A606_RS01565
uniprot id: S4XEE6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1200352:A606 RS05900
gene id: 1200352:A606_RS05900
uniprot id: S4XGM2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1200352:A606 RS08310
gene id: 1200352:A606_RS08310
uniprot id: S4XHV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS00125
gene id: 1200352:A606_RS00125
uniprot id: S4XAM4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1200352:A606 RS05360
gene id: 1200352:A606_RS05360
uniprot id: S4XDT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1200352:A606 RS11040
gene id: 1200352:A606_RS11040
uniprot id: S4XGT9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1200352:A606 RS07100
gene id: 1200352:A606_RS07100
uniprot id: S4XES2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1200352:A606 RS07440
gene id: 1200352:A606_RS07440
uniprot id: S4XEV1
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1200352:A606 RS08575
gene id: 1200352:A606_RS08575
uniprot id: S4XL46
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1200352:A606 RS08300
gene id: 1200352:A606_RS08300
uniprot id: S4XKZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1200352:A606 RS04630
gene id: 1200352:A606_RS04630
uniprot id: S4XBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS07470
gene id: 1200352:A606_RS07470
uniprot id: S4XHE3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1200352:A606 RS04825
gene id: 1200352:A606_RS04825
uniprot id: S4XDG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1200352:A606 RS02660
gene id: 1200352:A606_RS02660
uniprot id: S4XEZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1200352:A606 RS04280
gene id: 1200352:A606_RS04280
uniprot id: S4XFS6
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04620
gene id: 1200352:A606_RS04620
uniprot id: S4XFX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1200352:A606 RS07285
gene id: 1200352:A606_RS07285
uniprot id: S4XKG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1200352:A606 RS10140
gene id: 1200352:A606_RS10140
uniprot id: S4XIQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1200352:A606 RS06220
gene id: 1200352:A606_RS06220
uniprot id: S4XE79
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1200352:A606 RS00480
gene id: 1200352:A606_RS00480
uniprot id: S4XAU9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS05395
gene id: 1200352:A606_RS05395
uniprot id: S4XGC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1200352:A606 RS04240
gene id: 1200352:A606_RS04240
uniprot id: S4XBJ8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1200352:A606 RS05840
gene id: 1200352:A606_RS05840
uniprot id: S4XJN5
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1200352:A606 RS01495
gene id: 1200352:A606_RS01495
uniprot id: S4XBJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1200352:A606 RS06280
gene id: 1200352:A606_RS06280
uniprot id: S4XJY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1200352:A606 RS05225
gene id: 1200352:A606_RS05225
uniprot id: S4XDP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS09720
gene id: 1200352:A606_RS09720
uniprot id: S4XIJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1200352:A606 RS10145
gene id: 1200352:A606_RS10145
uniprot id: S4XGG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1200352:A606 RS08425
gene id: 1200352:A606_RS08425
uniprot id: S4XL22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1200352:A606 RS04640
gene id: 1200352:A606_RS04640
uniprot id: S4XDF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
messages: Membrane

1200352:A606 RS10290
gene id: 1200352:A606_RS10290
uniprot id: S4XGI4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1200352:A606 RS06470
gene id: 1200352:A606_RS06470
uniprot id: S4XEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1200352:A606 RS02645
gene id: 1200352:A606_RS02645
uniprot id: S4XAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1200352:A606 RS07650
gene id: 1200352:A606_RS07650
uniprot id: S4XDA9
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1200352:A606 RS02670
gene id: 1200352:A606_RS02670
uniprot id: S4XAL1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1200352:A606 RS01195
gene id: 1200352:A606_RS01195
uniprot id: S4XBP8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS08020
gene id: 1200352:A606_RS08020
uniprot id: S4XF58
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1200352:A606 RS03915
gene id: 1200352:A606_RS03915
uniprot id: S4XFK9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1200352:A606 RS04985
gene id: 1200352:A606_RS04985
uniprot id: S4XJ57
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1200352:A606 RS06100
gene id: 1200352:A606_RS06100
uniprot id: S4XE55
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1200352:A606 RS08690
gene id: 1200352:A606_RS08690
uniprot id: S4XI23
names: Similarity
messages: Belongs to the AccD/PCCB family.

1200352:A606 RS00460
gene id: 1200352:A606_RS00460
uniprot id: S4XDS5
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS09300
gene id: 1200352:A606_RS09300
uniprot id: S4XIF1
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1200352:A606 RS09100
gene id: 1200352:A606_RS09100
uniprot id: S4XIA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1200352:A606 RS02900
gene id: 1200352:A606_RS02900
uniprot id: S4XF28
names: Similarity
messages: Belongs to the citrate synthase family.

1200352:A606 RS10790
gene id: 1200352:A606_RS10790
uniprot id: S4XJ19
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS05135
gene id: 1200352:A606_RS05135
uniprot id: S4XJ88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1200352:A606 RS07490
gene id: 1200352:A606_RS07490
uniprot id: S4XEW0
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

1200352:A606 RS00445
gene id: 1200352:A606_RS00445
uniprot id: S4X9F8
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS00440
gene id: 1200352:A606_RS00440
uniprot id: S4XAT8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1200352:A606 RS02905
gene id: 1200352:A606_RS02905
uniprot id: S4XC99
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1200352:A606 RS04500
gene id: 1200352:A606_RS04500
uniprot id: S4XDA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1200352:A606 RS09810
gene id: 1200352:A606_RS09810
uniprot id: S4XLT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1200352:A606 RS05130
gene id: 1200352:A606_RS05130
uniprot id: S4XC02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1200352:A606 RS07405
gene id: 1200352:A606_RS07405
uniprot id: S4XD61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1200352:A606 RS07030
gene id: 1200352:A606_RS07030
uniprot id: S4XD11
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1200352:A606 RS11420
gene id: 1200352:A606_RS11420
uniprot id: S4XH44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1200352:A606 RS03960
gene id: 1200352:A606_RS03960
uniprot id: S4XCZ9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1200352:A606 RS00860
gene id: 1200352:A606_RS00860
uniprot id: S4X9N2
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1200352:A606 RS10440
gene id: 1200352:A606_RS10440
uniprot id: S4XEW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1200352:A606 RS08195
gene id: 1200352:A606_RS08195
uniprot id: S4XF90
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1200352:A606 RS11235
gene id: 1200352:A606_RS11235
uniprot id: S4XGX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1200352:A606 RS11585
gene id: 1200352:A606_RS11585
uniprot id: S4XH32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1200352:A606 RS02960
gene id: 1200352:A606_RS02960
uniprot id: S4XCA9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1200352:A606 RS08465
gene id: 1200352:A606_RS08465
uniprot id: S4XFG6
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS08085
gene id: 1200352:A606_RS08085
uniprot id: S4XDJ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS10210
gene id: 1200352:A606_RS10210
uniprot id: S4XIR1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1200352:A606 RS11155
gene id: 1200352:A606_RS11155
uniprot id: S4XMF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1200352:A606 RS04775
gene id: 1200352:A606_RS04775
uniprot id: S4XDF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1200352:A606 RS08490
gene id: 1200352:A606_RS08490
uniprot id: S4XFH0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1200352:A606 RS07040
gene id: 1200352:A606_RS07040
uniprot id: S4XEN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1200352:A606 RS01340
gene id: 1200352:A606_RS01340
uniprot id: S4X9X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1200352:A606 RS11750
gene id: 1200352:A606_RS11750
uniprot id: S4XHB7
names: Function
messages: Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.

1200352:A606 RS11600
gene id: 1200352:A606_RS11600
uniprot id: S4XFK0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS06555
gene id: 1200352:A606_RS06555
uniprot id: S4XCR4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1200352:A606 RS02565
gene id: 1200352:A606_RS02565
uniprot id: S4XC40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1200352:A606 RS10485
gene id: 1200352:A606_RS10485
uniprot id: S4XGM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1200352:A606 RS10355
gene id: 1200352:A606_RS10355
uniprot id: S4XGF6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1200352:A606 RS06985
gene id: 1200352:A606_RS06985
uniprot id: S4XKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1200352:A606 RS05945
gene id: 1200352:A606_RS05945
uniprot id: S4XE25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1200352:A606 RS02895
gene id: 1200352:A606_RS02895
uniprot id: S4XCI4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS08865
gene id: 1200352:A606_RS08865
uniprot id: S4XFL4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1200352:A606 RS04465
gene id: 1200352:A606_RS04465
uniprot id: S4XDC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1200352:A606 RS08510
gene id: 1200352:A606_RS08510
uniprot id: S4XHZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS01450
gene id: 1200352:A606_RS01450
uniprot id: S4X9Z2
names: Similarity
messages: Belongs to the peptidase S33 family.

1200352:A606 RS04435
gene id: 1200352:A606_RS04435
uniprot id: S4XIU2
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS06090
gene id: 1200352:A606_RS06090
uniprot id: S4XCI5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1200352:A606 RS07080
gene id: 1200352:A606_RS07080
uniprot id: S4XD17
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1200352:A606 RS07135
gene id: 1200352:A606_RS07135
uniprot id: S4XKE1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1200352:A606 RS08545
gene id: 1200352:A606_RS08545
uniprot id: S4XDT6
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01160
gene id: 1200352:A606_RS01160
uniprot id: S4X9T6
names: Caution
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1200352:A606 RS03895
gene id: 1200352:A606_RS03895
uniprot id: S4XCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1200352:A606 RS10800
gene id: 1200352:A606_RS10800
uniprot id: S4XF36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS06390
gene id: 1200352:A606_RS06390
uniprot id: S4XJZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1200352:A606 RS06060
gene id: 1200352:A606_RS06060
uniprot id: S4XE48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1200352:A606 RS09985
gene id: 1200352:A606_RS09985
uniprot id: S4XG87
names: Function
messages: Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.

1200352:A606 RS10030
gene id: 1200352:A606_RS10030
uniprot id: S4XLW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1200352:A606 RS07105
gene id: 1200352:A606_RS07105
uniprot id: S4XD20
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1200352:A606 RS06145
gene id: 1200352:A606_RS06145
uniprot id: S4XJV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1200352:A606 RS06675
gene id: 1200352:A606_RS06675
uniprot id: S4XEJ2
names: Similarity
messages: Belongs to the PspA/IM30 family.

1200352:A606 RS06260
gene id: 1200352:A606_RS06260
uniprot id: S4XE81
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS07395
gene id: 1200352:A606_RS07395
uniprot id: S4XHC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1200352:A606 RS06640
gene id: 1200352:A606_RS06640
uniprot id: S4XEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS11770
gene id: 1200352:A606_RS11770
uniprot id: S4XJL9
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

1200352:A606 RS07355
gene id: 1200352:A606_RS07355
uniprot id: S4XD52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS11820
gene id: 1200352:A606_RS11820
uniprot id: S4XJN3
names: Similarity
messages: Belongs to the peptidase C56 family.

1200352:A606 RS04245
gene id: 1200352:A606_RS04245
uniprot id: S4XIR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1200352:A606 RS12135
gene id: 1200352:A606_RS12135
uniprot id: S4XHL5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1200352:A606 RS01230
gene id: 1200352:A606_RS01230
uniprot id: S4XBC2
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS06140
gene id: 1200352:A606_RS06140
uniprot id: S4XCJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1200352:A606 RS09740
gene id: 1200352:A606_RS09740
uniprot id: S4XG40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1200352:A606 RS04850
gene id: 1200352:A606_RS04850
uniprot id: S4XDG8
names: Similarity
messages: Belongs to the asparaginase 1 family.

1200352:A606 RS01335
gene id: 1200352:A606_RS01335
uniprot id: S4XBE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1200352:A606 RS11270
gene id: 1200352:A606_RS11270
uniprot id: S4XH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1200352:A606 RS08445
gene id: 1200352:A606_RS08445
uniprot id: S4XDR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

1200352:A606 RS03245
gene id: 1200352:A606_RS03245
uniprot id: S4XCG6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1200352:A606 RS06720
gene id: 1200352:A606_RS06720
uniprot id: S4XH31
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

1200352:A606 RS02760
gene id: 1200352:A606_RS02760
uniprot id: S4XF06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS00530
gene id: 1200352:A606_RS00530
uniprot id: S4XAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1200352:A606 RS09090
gene id: 1200352:A606_RS09090
uniprot id: S4XLE0
names: Similarity
messages: Belongs to the AccD/PCCB family.

1200352:A606 RS09880
gene id: 1200352:A606_RS09880
uniprot id: S4XEJ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1200352:A606 RS04585
gene id: 1200352:A606_RS04585
uniprot id: S4XIW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1200352:A606 RS05910
gene id: 1200352:A606_RS05910
uniprot id: S4XCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1200352:A606 RS06925
gene id: 1200352:A606_RS06925
uniprot id: S4XEP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1200352:A606 RS08065
gene id: 1200352:A606_RS08065
uniprot id: S4XKU7
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1200352:A606 RS00775
gene id: 1200352:A606_RS00775
uniprot id: S4XBF9
names: Similarity
messages: Belongs to the peptidase M13 family.

1200352:A606 RS05065
gene id: 1200352:A606_RS05065
uniprot id: S4XDM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1200352:A606 RS08175
gene id: 1200352:A606_RS08175
uniprot id: S4XHS8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1200352:A606 RS07295
gene id: 1200352:A606_RS07295
uniprot id: S4XHB3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS07735
gene id: 1200352:A606_RS07735
uniprot id: S4XKN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1200352:A606 RS05760
gene id: 1200352:A606_RS05760
uniprot id: S4XJM1
names: Similarity
messages: Belongs to the UPF0098 family.

1200352:A606 RS00875
gene id: 1200352:A606_RS00875
uniprot id: S4XE02
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

1200352:A606 RS01545
gene id: 1200352:A606_RS01545
uniprot id: S4XBK7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS03350
gene id: 1200352:A606_RS03350
uniprot id: S4XB01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1200352:A606 RS09070
gene id: 1200352:A606_RS09070
uniprot id: S4XFQ0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1200352:A606 RS06165
gene id: 1200352:A606_RS06165
uniprot id: S4XCJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS07225
gene id: 1200352:A606_RS07225
uniprot id: S4XEU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1200352:A606 RS09425
gene id: 1200352:A606_RS09425
uniprot id: S4XFY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

1200352:A606 RS09075
gene id: 1200352:A606_RS09075
uniprot id: S4XI98
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS10125
gene id: 1200352:A606_RS10125
uniprot id: S4XEQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1200352:A606 RS10655
gene id: 1200352:A606_RS10655
uniprot id: S4XM54
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1200352:A606 RS09760
gene id: 1200352:A606_RS09760
uniprot id: S4XLS9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1200352:A606 RS01115
gene id: 1200352:A606_RS01115
uniprot id: S4XGU4
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS03980
gene id: 1200352:A606_RS03980
uniprot id: S4XIJ4
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS02000
gene id: 1200352:A606_RS02000
uniprot id: S4XA94
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1200352:A606 RS05170
gene id: 1200352:A606_RS05170
uniprot id: S4XG78
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1200352:A606 RS07150
gene id: 1200352:A606_RS07150
uniprot id: S4XET0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS09520
gene id: 1200352:A606_RS09520
uniprot id: S4XLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1200352:A606 RS07375
gene id: 1200352:A606_RS07375
uniprot id: S4XEW8
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1200352:A606 RS10785
gene id: 1200352:A606_RS10785
uniprot id: S4XGP1
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS01695
gene id: 1200352:A606_RS01695
uniprot id: S4XBN6
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS09905
gene id: 1200352:A606_RS09905
uniprot id: S4XEK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1200352:A606 RS09115
gene id: 1200352:A606_RS09115
uniprot id: S4XLE4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS03580
gene id: 1200352:A606_RS03580
uniprot id: S4XIA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1200352:A606 RS08405
gene id: 1200352:A606_RS08405
uniprot id: S4XFD0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1200352:A606 RS03630
gene id: 1200352:A606_RS03630
uniprot id: S4XIB5
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1200352:A606 RS08705
gene id: 1200352:A606_RS08705
uniprot id: S4XL75
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1200352:A606 RS02525
gene id: 1200352:A606_RS02525
uniprot id: S4XAI4
names: Similarity
messages: Belongs to the PrpD family.

1200352:A606 RS03240
gene id: 1200352:A606_RS03240
uniprot id: S4XF89
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1200352:A606 RS05110
gene id: 1200352:A606_RS05110
uniprot id: S4XJ84
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS10155
gene id: 1200352:A606_RS10155
uniprot id: S4XLY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1200352:A606 RS09970
gene id: 1200352:A606_RS09970
uniprot id: S4XGC7
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

1200352:A606 RS09400
gene id: 1200352:A606_RS09400
uniprot id: S4XFY3
names: Similarity
messages: Belongs to the peptidase C1 family.

1200352:A606 RS04685
gene id: 1200352:A606_RS04685
uniprot id: S4XIZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1200352:A606 RS01960
gene id: 1200352:A606_RS01960
uniprot id: S4XC46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1200352:A606 RS04625
gene id: 1200352:A606_RS04625
uniprot id: S4XDC4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS08295
gene id: 1200352:A606_RS08295
uniprot id: S4XDN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1200352:A606 RS12185
gene id: 1200352:A606_RS12185
uniprot id: S4XFX3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1200352:A606 RS06910
gene id: 1200352:A606_RS06910
uniprot id: S4XKA7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS03825
gene id: 1200352:A606_RS03825
uniprot id: S4XBA7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1200352:A606 RS03680
gene id: 1200352:A606_RS03680
uniprot id: S4XIC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1200352:A606 RS07690
gene id: 1200352:A606_RS07690
uniprot id: S4XEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

1200352:A606 RS02700
gene id: 1200352:A606_RS02700
uniprot id: S4XAL6
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

1200352:A606 RS11795
gene id: 1200352:A606_RS11795
uniprot id: S4XJN1
names: Similarity
messages: Belongs to the Dps family.

1200352:A606 RS07360
gene id: 1200352:A606_RS07360
uniprot id: S4XKH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1200352:A606 RS08115
gene id: 1200352:A606_RS08115
uniprot id: S4XKV9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1200352:A606 RS04270
gene id: 1200352:A606_RS04270
uniprot id: S4XIR7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1200352:A606 RS09050
gene id: 1200352:A606_RS09050
uniprot id: S4XI93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1200352:A606 RS09055
gene id: 1200352:A606_RS09055
uniprot id: S4XFS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1200352:A606 RS05235
gene id: 1200352:A606_RS05235
uniprot id: S4XJB1
names: Similarity
messages: Belongs to the UPF0434 family.

1200352:A606 RS03550
gene id: 1200352:A606_RS03550
uniprot id: S4XCU1
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1200352:A606 RS11545
gene id: 1200352:A606_RS11545
uniprot id: S4XH70
names: Similarity
messages: Belongs to the UPF0145 family.

1200352:A606 RS05125
gene id: 1200352:A606_RS05125
uniprot id: S4XDM2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1200352:A606 RS07140
gene id: 1200352:A606_RS07140
uniprot id: S4XEP8
names: Similarity
messages: Belongs to the acylphosphatase family.

1200352:A606 RS09915
gene id: 1200352:A606_RS09915
uniprot id: S4XG74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1200352:A606 RS11790
gene id: 1200352:A606_RS11790
uniprot id: S4XH84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1200352:A606 RS11440
gene id: 1200352:A606_RS11440
uniprot id: S4XH09
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1200352:A606 RS10380
gene id: 1200352:A606_RS10380
uniprot id: S4XIT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1200352:A606 RS05660
gene id: 1200352:A606_RS05660
uniprot id: S4XJK0
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

1200352:A606 RS04820
gene id: 1200352:A606_RS04820
uniprot id: S4XG07
names: Similarity
messages: Belongs to the YggT family.

1200352:A606 RS11965
gene id: 1200352:A606_RS11965
uniprot id: S4XFT3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1200352:A606 RS10170
gene id: 1200352:A606_RS10170
uniprot id: S4XGG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1200352:A606 RS00065
gene id: 1200352:A606_RS00065
uniprot id: S4XAL2
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

1200352:A606 RS12375
gene id: 1200352:A606_RS12375
uniprot id: S4XD01
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS07435
gene id: 1200352:A606_RS07435
uniprot id: S4XKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1200352:A606 RS03660
gene id: 1200352:A606_RS03660
uniprot id: S4XCV7
names: Similarity
messages: Belongs to the LOG family.

1200352:A606 RS00290
gene id: 1200352:A606_RS00290
uniprot id: S4XDP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1200352:A606 RS02830
gene id: 1200352:A606_RS02830
uniprot id: S4XC83
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1200352:A606 RS04970
gene id: 1200352:A606_RS04970
uniprot id: S4XG36
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1200352:A606 RS08855
gene id: 1200352:A606_RS08855
uniprot id: S4XDZ8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1200352:A606 RS06725
gene id: 1200352:A606_RS06725
uniprot id: S4XEK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1200352:A606 RS10835
gene id: 1200352:A606_RS10835
uniprot id: S4XGQ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS08095
gene id: 1200352:A606_RS08095
uniprot id: S4XF72
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

1200352:A606 RS11220
gene id: 1200352:A606_RS11220
uniprot id: S4XH08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1200352:A606 RS02160
gene id: 1200352:A606_RS02160
uniprot id: S4XEP7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1200352:A606 RS02510
gene id: 1200352:A606_RS02510
uniprot id: S4XCC9
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1200352:A606 RS02425
gene id: 1200352:A606_RS02425
uniprot id: S4XAG0
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1200352:A606 RS07975
gene id: 1200352:A606_RS07975
uniprot id: S4XHP2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1200352:A606 RS10985
gene id: 1200352:A606_RS10985
uniprot id: S4XGS9
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

1200352:A606 RS03865
gene id: 1200352:A606_RS03865
uniprot id: S4XFK3
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS08080
gene id: 1200352:A606_RS08080
uniprot id: S4XF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

1200352:A606 RS11230
gene id: 1200352:A606_RS11230
uniprot id: S4XMG3
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1200352:A606 RS00110
gene id: 1200352:A606_RS00110
uniprot id: S4XG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1200352:A606 RS10105
gene id: 1200352:A606_RS10105
uniprot id: S4XLX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1200352:A606 RS03045
gene id: 1200352:A606_RS03045
uniprot id: S4XI00
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1200352:A606 RS12175
gene id: 1200352:A606_RS12175
uniprot id: S4XHH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1200352:A606 RS02030
gene id: 1200352:A606_RS02030
uniprot id: S4XHD0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1200352:A606 RS11825
gene id: 1200352:A606_RS11825
uniprot id: S4XHF3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1200352:A606 RS07450
gene id: 1200352:A606_RS07450
uniprot id: S4XEY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS09345
gene id: 1200352:A606_RS09345
uniprot id: S4XLM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1200352:A606 RS01550
gene id: 1200352:A606_RS01550
uniprot id: S4XA25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

1200352:A606 RS10120
gene id: 1200352:A606_RS10120
uniprot id: S4XGF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1200352:A606 RS11245
gene id: 1200352:A606_RS11245
uniprot id: S4XH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm

1200352:A606 RS04765
gene id: 1200352:A606_RS04765
uniprot id: S4XDH3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS03470
gene id: 1200352:A606_RS03470
uniprot id: S4XCL1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1200352:A606 RS06115
gene id: 1200352:A606_RS06115
uniprot id: S4XCJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1200352:A606 RS09295
gene id: 1200352:A606_RS09295
uniprot id: S4XFW1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1200352:A606 RS07125
gene id: 1200352:A606_RS07125
uniprot id: S4XES7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1200352:A606 RS06800
gene id: 1200352:A606_RS06800
uniprot id: S4XEL6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1200352:A606 RS07215
gene id: 1200352:A606_RS07215
uniprot id: S4XER2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1200352:A606 RS11565
gene id: 1200352:A606_RS11565
uniprot id: S4XJH1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1200352:A606 RS01875
gene id: 1200352:A606_RS01875
uniprot id: S4XA74
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1200352:A606 RS08380
gene id: 1200352:A606_RS08380
uniprot id: S4XFC5
names: Similarity
messages: Belongs to the GcvT family.

1200352:A606 RS01720
gene id: 1200352:A606_RS01720
uniprot id: S4XBN8
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1200352:A606 RS09350
gene id: 1200352:A606_RS09350
uniprot id: S4XFW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1200352:A606 RS09980
gene id: 1200352:A606_RS09980
uniprot id: S4XLV8
names: Similarity
messages: Belongs to the DszC flavin monooxygenase family.

1200352:A606 RS09700
gene id: 1200352:A606_RS09700
uniprot id: S4XG75
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS05985
gene id: 1200352:A606_RS05985
uniprot id: S4XCG5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1200352:A606 RS07510
gene id: 1200352:A606_RS07510
uniprot id: S4XKJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1200352:A606 RS09210
gene id: 1200352:A606_RS09210
uniprot id: S4XE83
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS04925
gene id: 1200352:A606_RS04925
uniprot id: S4XDI2
names: Similarity
messages: Belongs to the HSP15 family.

1200352:A606 RS04345
gene id: 1200352:A606_RS04345
uniprot id: S4XIT0
names: Similarity
messages: Belongs to the neutral ceramidase family.

1200352:A606 RS06105
gene id: 1200352:A606_RS06105
uniprot id: S4XGR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1200352:A606 RS01855
gene id: 1200352:A606_RS01855
uniprot id: S4XH96
names: Subcellular Location Annotation
messages: Membrane

1200352:A606 RS06070
gene id: 1200352:A606_RS06070
uniprot id: S4XJT9
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1200352:A606 RS03410
gene id: 1200352:A606_RS03410
uniprot id: S4XCS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

1200352:A606 RS12075
gene id: 1200352:A606_RS12075
uniprot id: S4XHE9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1200352:A606 RS10015
gene id: 1200352:A606_RS10015
uniprot id: S4XIN5
names: Similarity
messages: Belongs to the glutamate synthase family.

1200352:A606 RS07460
gene id: 1200352:A606_RS07460
uniprot id: S4XKI8
names: Similarity
messages: Belongs to the Nudix hydrolase family.