1193502:SHALO RS00765
gene id: 1193502:SHALO_RS00765
uniprot id: A0A1D7TG29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS12165
gene id: 1193502:SHALO_RS12165
uniprot id: A0A1D7TMH6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1193502:SHALO RS02800
gene id: 1193502:SHALO_RS02800
uniprot id: A0A1D7TH40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1193502:SHALO RS07250
gene id: 1193502:SHALO_RS07250
uniprot id: A0A1D7TJL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1193502:SHALO RS07440
gene id: 1193502:SHALO_RS07440
uniprot id: A0A1D7TJS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

1193502:SHALO RS06195
gene id: 1193502:SHALO_RS06195
uniprot id: A0A1D7TJ52
names: Similarity
messages: Belongs to the class-D beta-lactamase family.

1193502:SHALO RS08390
gene id: 1193502:SHALO_RS08390
uniprot id: A0A1D7TKA4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1193502:SHALO RS14150
gene id: 1193502:SHALO_RS14150
uniprot id: A0A1D7TNS4
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS01315
gene id: 1193502:SHALO_RS01315
uniprot id: A0A1D7TGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

1193502:SHALO RS04215
gene id: 1193502:SHALO_RS04215
uniprot id: A0A1D7TI53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

1193502:SHALO RS01670
gene id: 1193502:SHALO_RS01670
uniprot id: A0A1D7TGK4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1193502:SHALO RS13030
gene id: 1193502:SHALO_RS13030
uniprot id: A0A1D7TMY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS04515
gene id: 1193502:SHALO_RS04515
uniprot id: A0A1D7TI47
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1193502:SHALO RS01890
gene id: 1193502:SHALO_RS01890
uniprot id: A0A1D7TGQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1193502:SHALO RS11480
gene id: 1193502:SHALO_RS11480
uniprot id: A0A1D7TM20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1193502:SHALO RS00300
gene id: 1193502:SHALO_RS00300
uniprot id: A0A1D7TFT4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1193502:SHALO RS11405
gene id: 1193502:SHALO_RS11405
uniprot id: A0A1D7TM17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1193502:SHALO RS13395
gene id: 1193502:SHALO_RS13395
uniprot id: A0A1D7TN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1193502:SHALO RS10110
gene id: 1193502:SHALO_RS10110
uniprot id: A0A1D7TLB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1193502:SHALO RS06815
gene id: 1193502:SHALO_RS06815
uniprot id: A0A1D7TJC6
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1193502:SHALO RS05745
gene id: 1193502:SHALO_RS05745
uniprot id: A0A1D7TJ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1193502:SHALO RS01180
gene id: 1193502:SHALO_RS01180
uniprot id: A0A1D7TGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1193502:SHALO RS15145
gene id: 1193502:SHALO_RS15145
uniprot id: A0A1D7TP49
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

1193502:SHALO RS07385
gene id: 1193502:SHALO_RS07385
uniprot id: A0A1D7TJR7
names: Similarity
messages: Belongs to the ClpX chaperone family. HslU subfamily.

1193502:SHALO RS07515
gene id: 1193502:SHALO_RS07515
uniprot id: A0A1D7TJU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1193502:SHALO RS05625
gene id: 1193502:SHALO_RS05625
uniprot id: A0A1D7TIU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

1193502:SHALO RS15115
gene id: 1193502:SHALO_RS15115
uniprot id: A0A1D7TP46
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS01295
gene id: 1193502:SHALO_RS01295
uniprot id: A0A1D7TGB3
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS02610
gene id: 1193502:SHALO_RS02610
uniprot id: A0A1D7THI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS07265
gene id: 1193502:SHALO_RS07265
uniprot id: A0A1D7TJL5
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS09790
gene id: 1193502:SHALO_RS09790
uniprot id: A0A1D7TL82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1193502:SHALO RS00540
gene id: 1193502:SHALO_RS00540
uniprot id: A0A1D7TFW5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1193502:SHALO RS01740
gene id: 1193502:SHALO_RS01740
uniprot id: A0A1D7TGS7
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS03620
gene id: 1193502:SHALO_RS03620
uniprot id: A0A1D7THJ1
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS12810
gene id: 1193502:SHALO_RS12810
uniprot id: A0A1D7TMV4
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1193502:SHALO RS09080
gene id: 1193502:SHALO_RS09080
uniprot id: A0A1D7TKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

1193502:SHALO RS14545
gene id: 1193502:SHALO_RS14545
uniprot id: A0A1D7TNV8
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1193502:SHALO RS12425
gene id: 1193502:SHALO_RS12425
uniprot id: A0A1D7TMT9
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1193502:SHALO RS12320
gene id: 1193502:SHALO_RS12320
uniprot id: A0A1D7TMS2
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1193502:SHALO RS04555
gene id: 1193502:SHALO_RS04555
uniprot id: A0A1D7TI67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-552 family.
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 5 heme c groups covalently per monomer.
messages: Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
messages: Periplasm

1193502:SHALO RS08660
gene id: 1193502:SHALO_RS08660
uniprot id: A0A1D7TKP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

1193502:SHALO RS06250
gene id: 1193502:SHALO_RS06250
uniprot id: A0A1D7TJ48
names: Similarity
messages: Belongs to the PhzF family.

1193502:SHALO RS03530
gene id: 1193502:SHALO_RS03530
uniprot id: A0A1D7THM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1193502:SHALO RS02280
gene id: 1193502:SHALO_RS02280
uniprot id: A0A1D7THC4
names: Similarity
messages: Belongs to the thioredoxin family.

1193502:SHALO RS13425
gene id: 1193502:SHALO_RS13425
uniprot id: A0A1D7TN76
names: Similarity
messages: Belongs to the UPF0166 family.

1193502:SHALO RS02875
gene id: 1193502:SHALO_RS02875
uniprot id: A0A1D7TH91
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS06105
gene id: 1193502:SHALO_RS06105
uniprot id: A0A1D7TIY6
names: Similarity
messages: Belongs to the NifX/NifY family.

1193502:SHALO RS05350
gene id: 1193502:SHALO_RS05350
uniprot id: A0A1D7TIM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1193502:SHALO RS10060
gene id: 1193502:SHALO_RS10060
uniprot id: A0A1D7TLA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

1193502:SHALO RS01170
gene id: 1193502:SHALO_RS01170
uniprot id: A0A1D7TG76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1193502:SHALO RS11790
gene id: 1193502:SHALO_RS11790
uniprot id: A0A1D7TM97
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1193502:SHALO RS07160
gene id: 1193502:SHALO_RS07160
uniprot id: A0A1D7TJK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1193502:SHALO RS14250
gene id: 1193502:SHALO_RS14250
uniprot id: A0A1D7TNN1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1193502:SHALO RS12620
gene id: 1193502:SHALO_RS12620
uniprot id: A0A1D7TMX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1193502:SHALO RS10150
gene id: 1193502:SHALO_RS10150
uniprot id: A0A1D7TLD3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1193502:SHALO RS04250
gene id: 1193502:SHALO_RS04250
uniprot id: A0A1D7TI18
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00810
gene id: 1193502:SHALO_RS00810
uniprot id: A0A1D7TG34
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1193502:SHALO RS12005
gene id: 1193502:SHALO_RS12005
uniprot id: A0A1D7TMD2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1193502:SHALO RS03880
gene id: 1193502:SHALO_RS03880
uniprot id: A0A1D7THQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1193502:SHALO RS11025
gene id: 1193502:SHALO_RS11025
uniprot id: A0A1D7TLT6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1193502:SHALO RS08505
gene id: 1193502:SHALO_RS08505
uniprot id: A0A1D7TKD5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1193502:SHALO RS00470
gene id: 1193502:SHALO_RS00470
uniprot id: A0A1D7TFX2
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1193502:SHALO RS03750
gene id: 1193502:SHALO_RS03750
uniprot id: A0A1D7THL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS07675
gene id: 1193502:SHALO_RS07675
uniprot id: A0A1D7TJX2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1193502:SHALO RS01265
gene id: 1193502:SHALO_RS01265
uniprot id: A0A1D7TGB9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1193502:SHALO RS01350
gene id: 1193502:SHALO_RS01350
uniprot id: A0A1D7TGD4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS13350
gene id: 1193502:SHALO_RS13350
uniprot id: A0A1D7TN73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1193502:SHALO RS06555
gene id: 1193502:SHALO_RS06555
uniprot id: A0A1D7TJ75
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06400
gene id: 1193502:SHALO_RS06400
uniprot id: A0A1D7TJ88
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1193502:SHALO RS04610
gene id: 1193502:SHALO_RS04610
uniprot id: A0A1D7TI41
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1193502:SHALO RS01090
gene id: 1193502:SHALO_RS01090
uniprot id: A0A1D7TG65
names: Similarity
messages: Belongs to the UPF0102 family.

1193502:SHALO RS11175
gene id: 1193502:SHALO_RS11175
uniprot id: A0A1D7TLW4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1193502:SHALO RS03610
gene id: 1193502:SHALO_RS03610
uniprot id: A0A1D7THM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

1193502:SHALO RS13710
gene id: 1193502:SHALO_RS13710
uniprot id: A0A1D7TNE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MerT family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS10365
gene id: 1193502:SHALO_RS10365
uniprot id: A0A1D7TLF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1193502:SHALO RS08520
gene id: 1193502:SHALO_RS08520
uniprot id: A0A1D7TKE0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1193502:SHALO RS14350
gene id: 1193502:SHALO_RS14350
uniprot id: A0A1D7TNR0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1193502:SHALO RS04925
gene id: 1193502:SHALO_RS04925
uniprot id: A0A1D7TIE6
names: Similarity
messages: Belongs to the DEAD box helicase family.

1193502:SHALO RS03150
gene id: 1193502:SHALO_RS03150
uniprot id: A0A1D7THA5
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS12795
gene id: 1193502:SHALO_RS12795
uniprot id: A0A1D7TMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS11015
gene id: 1193502:SHALO_RS11015
uniprot id: A0A1D7TLT1
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1193502:SHALO RS02455
gene id: 1193502:SHALO_RS02455
uniprot id: A0A1D7THF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1193502:SHALO RS04060
gene id: 1193502:SHALO_RS04060
uniprot id: A0A1D7THS9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1193502:SHALO RS00085
gene id: 1193502:SHALO_RS00085
uniprot id: A0A1D7TFW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1193502:SHALO RS07650
gene id: 1193502:SHALO_RS07650
uniprot id: A0A1D7TK55
names: Similarity
messages: Belongs to the CobH/CbiC family.

1193502:SHALO RS04080
gene id: 1193502:SHALO_RS04080
uniprot id: A0A1D7THZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1193502:SHALO RS10455
gene id: 1193502:SHALO_RS10455
uniprot id: A0A1D7TLH4
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS03805
gene id: 1193502:SHALO_RS03805
uniprot id: A0A1D7THR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1193502:SHALO RS04450
gene id: 1193502:SHALO_RS04450
uniprot id: A0A1D7TI61
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1193502:SHALO RS09540
gene id: 1193502:SHALO_RS09540
uniprot id: A0A1D7TKZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

1193502:SHALO RS13920
gene id: 1193502:SHALO_RS13920
uniprot id: A0A1D7TNH6
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS13870
gene id: 1193502:SHALO_RS13870
uniprot id: A0A1D7TNG7
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS07900
gene id: 1193502:SHALO_RS07900
uniprot id: A0A1D7TK17
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

1193502:SHALO RS08765
gene id: 1193502:SHALO_RS08765
uniprot id: A0A1D7TKJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1193502:SHALO RS04750
gene id: 1193502:SHALO_RS04750
uniprot id: A0A1D7TIB6
names: Similarity
messages: Belongs to the SCO1/2 family.

1193502:SHALO RS08270
gene id: 1193502:SHALO_RS08270
uniprot id: A0A1D7TKB0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1193502:SHALO RS05845
gene id: 1193502:SHALO_RS05845
uniprot id: A0A1D7TJ30
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1193502:SHALO RS10880
gene id: 1193502:SHALO_RS10880
uniprot id: A0A1D7TLS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1193502:SHALO RS00650
gene id: 1193502:SHALO_RS00650
uniprot id: A0A1D7TGC5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1193502:SHALO RS13825
gene id: 1193502:SHALO_RS13825
uniprot id: A0A1D7TNF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1193502:SHALO RS00550
gene id: 1193502:SHALO_RS00550
uniprot id: A0A1D7TFY1
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1193502:SHALO RS03765
gene id: 1193502:SHALO_RS03765
uniprot id: A0A1D7THQ6
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS12565
gene id: 1193502:SHALO_RS12565
uniprot id: A0A1D7TMQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1193502:SHALO RS12685
gene id: 1193502:SHALO_RS12685
uniprot id: A0A1D7TMR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS12120
gene id: 1193502:SHALO_RS12120
uniprot id: A0A1D7TMN2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1193502:SHALO RS10230
gene id: 1193502:SHALO_RS10230
uniprot id: A0A1D7TLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1193502:SHALO RS14310
gene id: 1193502:SHALO_RS14310
uniprot id: A0A1D7TNU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1193502:SHALO RS03890
gene id: 1193502:SHALO_RS03890
uniprot id: A0A1D7THV7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1193502:SHALO RS00310
gene id: 1193502:SHALO_RS00310
uniprot id: A0A1D7TFR9
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1193502:SHALO RS09755
gene id: 1193502:SHALO_RS09755
uniprot id: A0A1D7TL53
names: Similarity
messages: Belongs to the PrpD family.

1193502:SHALO RS04240
gene id: 1193502:SHALO_RS04240
uniprot id: A0A1D7TID0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1193502:SHALO RS00440
gene id: 1193502:SHALO_RS00440
uniprot id: A0A1D7TFU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS07260
gene id: 1193502:SHALO_RS07260
uniprot id: A0A1D7TJQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane

1193502:SHALO RS13545
gene id: 1193502:SHALO_RS13545
uniprot id: A0A1D7TN91
names: Similarity
messages: Belongs to the pirin family.

1193502:SHALO RS08675
gene id: 1193502:SHALO_RS08675
uniprot id: A0A1D7TKH8
names: Similarity
messages: Belongs to the TlyA family.

1193502:SHALO RS12825
gene id: 1193502:SHALO_RS12825
uniprot id: A0A1D7TMU2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1193502:SHALO RS12995
gene id: 1193502:SHALO_RS12995
uniprot id: A0A1D7TMZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

1193502:SHALO RS02590
gene id: 1193502:SHALO_RS02590
uniprot id: A0A1D7TH71
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1193502:SHALO RS04645
gene id: 1193502:SHALO_RS04645
uniprot id: A0A1D7TI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS14865
gene id: 1193502:SHALO_RS14865
uniprot id: A0A1D7TP12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1193502:SHALO RS05950
gene id: 1193502:SHALO_RS05950
uniprot id: A0A1D7TIZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1193502:SHALO RS07980
gene id: 1193502:SHALO_RS07980
uniprot id: A0A1D7TK25
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1193502:SHALO RS11835
gene id: 1193502:SHALO_RS11835
uniprot id: A0A1D7TMA4
names: Similarity
messages: Belongs to the PhoU family.

1193502:SHALO RS11785
gene id: 1193502:SHALO_RS11785
uniprot id: A0A1D7TM90
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS06920
gene id: 1193502:SHALO_RS06920
uniprot id: A0A1D7TJP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1193502:SHALO RS02565
gene id: 1193502:SHALO_RS02565
uniprot id: A0A1D7TH01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS03185
gene id: 1193502:SHALO_RS03185
uniprot id: A0A1D7THD5
names: Similarity
messages: Belongs to the YoeB family.

1193502:SHALO RS03475
gene id: 1193502:SHALO_RS03475
uniprot id: A0A1D7THF9
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1193502:SHALO RS09045
gene id: 1193502:SHALO_RS09045
uniprot id: A0A1D7TKT7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS03035
gene id: 1193502:SHALO_RS03035
uniprot id: A0A1D7THH1
names: Similarity
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.

1193502:SHALO RS02820
gene id: 1193502:SHALO_RS02820
uniprot id: A0A1D7TH96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1193502:SHALO RS02675
gene id: 1193502:SHALO_RS02675
uniprot id: A0A1D7TH54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1193502:SHALO RS03370
gene id: 1193502:SHALO_RS03370
uniprot id: A0A1D7THI3
names: Similarity
messages: Belongs to the pyruvate kinase family.

1193502:SHALO RS02215
gene id: 1193502:SHALO_RS02215
uniprot id: A0A1D7TGV4
names: Similarity
messages: Belongs to the XFP family.

1193502:SHALO RS03755
gene id: 1193502:SHALO_RS03755
uniprot id: A0A1D7THQ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS14525
gene id: 1193502:SHALO_RS14525
uniprot id: A0A1D7TNS3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1193502:SHALO RS02790
gene id: 1193502:SHALO_RS02790
uniprot id: A0A1D7THB3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1193502:SHALO RS05405
gene id: 1193502:SHALO_RS05405
uniprot id: A0A1D7TIK8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1193502:SHALO RS05530
gene id: 1193502:SHALO_RS05530
uniprot id: A0A1D7TIR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1193502:SHALO RS13680
gene id: 1193502:SHALO_RS13680
uniprot id: A0A1D7TNI0
names: Similarity
messages: Belongs to the DEAD box helicase family.

1193502:SHALO RS01130
gene id: 1193502:SHALO_RS01130
uniprot id: A0A1D7TGF8
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1193502:SHALO RS04725
gene id: 1193502:SHALO_RS04725
uniprot id: A0A1D7TIB2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1193502:SHALO RS14770
gene id: 1193502:SHALO_RS14770
uniprot id: A0A1D7TNY0
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS11045
gene id: 1193502:SHALO_RS11045
uniprot id: A0A1D7TLT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1193502:SHALO RS02880
gene id: 1193502:SHALO_RS02880
uniprot id: A0A1D7TH47
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

1193502:SHALO RS12130
gene id: 1193502:SHALO_RS12130
uniprot id: A0A1D7TME7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1193502:SHALO RS07945
gene id: 1193502:SHALO_RS07945
uniprot id: A0A1D7TK23
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1193502:SHALO RS07920
gene id: 1193502:SHALO_RS07920
uniprot id: A0A1D7TK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS07295
gene id: 1193502:SHALO_RS07295
uniprot id: A0A1D7TJZ6
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1193502:SHALO RS10935
gene id: 1193502:SHALO_RS10935
uniprot id: A0A1D7TLT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

1193502:SHALO RS07110
gene id: 1193502:SHALO_RS07110
uniprot id: A0A1D7TJJ2
names: Similarity
messages: Belongs to the HypD family.

1193502:SHALO RS08060
gene id: 1193502:SHALO_RS08060
uniprot id: A0A1D7TKD6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1193502:SHALO RS05555
gene id: 1193502:SHALO_RS05555
uniprot id: A0A1D7TIN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1193502:SHALO RS08645
gene id: 1193502:SHALO_RS08645
uniprot id: A0A1D7TKH1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1193502:SHALO RS05780
gene id: 1193502:SHALO_RS05780
uniprot id: A0A1D7TIW1
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS10085
gene id: 1193502:SHALO_RS10085
uniprot id: A0A1D7TLA5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1193502:SHALO RS14850
gene id: 1193502:SHALO_RS14850
uniprot id: A0A1D7TNY6
names: Similarity
messages: Belongs to the catalase family.

1193502:SHALO RS08860
gene id: 1193502:SHALO_RS08860
uniprot id: A0A1D7TKK7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1193502:SHALO RS15435
gene id: 1193502:SHALO_RS15435
uniprot id: A0A1D7TIC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1193502:SHALO RS14455
gene id: 1193502:SHALO_RS14455
uniprot id: A0A1D7TNT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1193502:SHALO RS08120
gene id: 1193502:SHALO_RS08120
uniprot id: A0A1D7TK81
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1193502:SHALO RS14520
gene id: 1193502:SHALO_RS14520
uniprot id: A0A1D7TNS6
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

1193502:SHALO RS00090
gene id: 1193502:SHALO_RS00090
uniprot id: A0A1D7TFP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1193502:SHALO RS02555
gene id: 1193502:SHALO_RS02555
uniprot id: A0A1D7TH36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS04035
gene id: 1193502:SHALO_RS04035
uniprot id: A0A1D7THY4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1193502:SHALO RS03980
gene id: 1193502:SHALO_RS03980
uniprot id: A0A1D7THQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1193502:SHALO RS04345
gene id: 1193502:SHALO_RS04345
uniprot id: A0A1D7THZ9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

1193502:SHALO RS03285
gene id: 1193502:SHALO_RS03285
uniprot id: A0A1D7THW0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1193502:SHALO RS05490
gene id: 1193502:SHALO_RS05490
uniprot id: A0A1D7TIN4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS11430
gene id: 1193502:SHALO_RS11430
uniprot id: A0A1D7TM50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS03335
gene id: 1193502:SHALO_RS03335
uniprot id: A0A1D7THW9
names: Similarity
messages: Belongs to the RutC family.

1193502:SHALO RS11730
gene id: 1193502:SHALO_RS11730
uniprot id: A0A1D7TM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1193502:SHALO RS10570
gene id: 1193502:SHALO_RS10570
uniprot id: A0A1D7TLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS07240
gene id: 1193502:SHALO_RS07240
uniprot id: A0A1D7TJP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1193502:SHALO RS04130
gene id: 1193502:SHALO_RS04130
uniprot id: A0A1D7TI02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1193502:SHALO RS05735
gene id: 1193502:SHALO_RS05735
uniprot id: A0A1D7TIS2
names: Subcellular Location Annotation
messages: Mitochondrion

1193502:SHALO RS02745
gene id: 1193502:SHALO_RS02745
uniprot id: A0A1D7TH59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1193502:SHALO RS11275
gene id: 1193502:SHALO_RS11275
uniprot id: A0A1D7TLY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1193502:SHALO RS08315
gene id: 1193502:SHALO_RS08315
uniprot id: A0A1D7TKA1
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1193502:SHALO RS07510
gene id: 1193502:SHALO_RS07510
uniprot id: A0A1D7TJV8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1193502:SHALO RS02560
gene id: 1193502:SHALO_RS02560
uniprot id: A0A1D7THH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS07100
gene id: 1193502:SHALO_RS07100
uniprot id: A0A1D7TJM4
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

1193502:SHALO RS13145
gene id: 1193502:SHALO_RS13145
uniprot id: A0A1D7TN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1193502:SHALO RS05650
gene id: 1193502:SHALO_RS05650
uniprot id: A0A1D7TIT4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1193502:SHALO RS11565
gene id: 1193502:SHALO_RS11565
uniprot id: A0A1D7TM42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1193502:SHALO RS08670
gene id: 1193502:SHALO_RS08670
uniprot id: A0A1D7TKI2
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

1193502:SHALO RS06630
gene id: 1193502:SHALO_RS06630
uniprot id: A0A1D7TJD3
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1193502:SHALO RS12070
gene id: 1193502:SHALO_RS12070
uniprot id: A0A1D7TMM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1193502:SHALO RS00640
gene id: 1193502:SHALO_RS00640
uniprot id: A0A1D7TFX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1193502:SHALO RS14475
gene id: 1193502:SHALO_RS14475
uniprot id: A0A1D7TNR1
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1193502:SHALO RS12100
gene id: 1193502:SHALO_RS12100
uniprot id: A0A1D7TMG4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1193502:SHALO RS08135
gene id: 1193502:SHALO_RS08135
uniprot id: A0A1D7TK60
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1193502:SHALO RS01285
gene id: 1193502:SHALO_RS01285
uniprot id: A0A1D7TGI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1193502:SHALO RS10380
gene id: 1193502:SHALO_RS10380
uniprot id: A0A1D7TLG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1193502:SHALO RS11420
gene id: 1193502:SHALO_RS11420
uniprot id: A0A1D7TM16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1193502:SHALO RS09570
gene id: 1193502:SHALO_RS09570
uniprot id: A0A1D7TKZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1193502:SHALO RS10490
gene id: 1193502:SHALO_RS10490
uniprot id: A0A1D7TLK2
names: Similarity
messages: Belongs to the CitG/MdcB family.

1193502:SHALO RS05585
gene id: 1193502:SHALO_RS05585
uniprot id: A0A1D7TIP2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

1193502:SHALO RS13015
gene id: 1193502:SHALO_RS13015
uniprot id: A0A1D7TN57
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1193502:SHALO RS04260
gene id: 1193502:SHALO_RS04260
uniprot id: A0A1D7THW6
names: Subcellular Location Annotation
names: Subunit
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane

1193502:SHALO RS06965
gene id: 1193502:SHALO_RS06965
uniprot id: A0A1D7TJH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

1193502:SHALO RS13885
gene id: 1193502:SHALO_RS13885
uniprot id: A0A1D7TNF0
names: Similarity
messages: Belongs to the YkuD family.

1193502:SHALO RS02670
gene id: 1193502:SHALO_RS02670
uniprot id: A0A1D7TH63
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1193502:SHALO RS11030
gene id: 1193502:SHALO_RS11030
uniprot id: A0A1D7TLW3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS09625
gene id: 1193502:SHALO_RS09625
uniprot id: A0A1D7TL30
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS01380
gene id: 1193502:SHALO_RS01380
uniprot id: A0A1D7TGE9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1193502:SHALO RS13340
gene id: 1193502:SHALO_RS13340
uniprot id: A0A1D7TN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1193502:SHALO RS08585
gene id: 1193502:SHALO_RS08585
uniprot id: A0A1D7TKF3
names: Similarity
messages: Belongs to the threonine synthase family.

1193502:SHALO RS03385
gene id: 1193502:SHALO_RS03385
uniprot id: A0A1D7THX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1193502:SHALO RS03990
gene id: 1193502:SHALO_RS03990
uniprot id: A0A1D7TI84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane

1193502:SHALO RS03525
gene id: 1193502:SHALO_RS03525
uniprot id: A0A1D7THG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1193502:SHALO RS14745
gene id: 1193502:SHALO_RS14745
uniprot id: A0A1D7TNW1
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00975
gene id: 1193502:SHALO_RS00975
uniprot id: A0A1D7TG69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS08030
gene id: 1193502:SHALO_RS08030
uniprot id: A0A1D7TK43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1193502:SHALO RS05400
gene id: 1193502:SHALO_RS05400
uniprot id: A0A1D7TIP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1193502:SHALO RS03290
gene id: 1193502:SHALO_RS03290
uniprot id: A0A1D7THC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1193502:SHALO RS06780
gene id: 1193502:SHALO_RS06780
uniprot id: A0A1D7TJC1
names: Similarity
messages: Belongs to the nitroreductase family.

1193502:SHALO RS10950
gene id: 1193502:SHALO_RS10950
uniprot id: A0A1D7TM08
names: Similarity
messages: Belongs to the hemerythrin family.

1193502:SHALO RS08430
gene id: 1193502:SHALO_RS08430
uniprot id: A0A1D7TKC6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1193502:SHALO RS11665
gene id: 1193502:SHALO_RS11665
uniprot id: A0A1D7TMF3
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

1193502:SHALO RS14255
gene id: 1193502:SHALO_RS14255
uniprot id: A0A1D7TNU1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1193502:SHALO RS07395
gene id: 1193502:SHALO_RS07395
uniprot id: A0A1D7TK14
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1193502:SHALO RS09860
gene id: 1193502:SHALO_RS09860
uniprot id: A0A1D7TLE0
names: Similarity
messages: Belongs to the FeoA family.

1193502:SHALO RS06935
gene id: 1193502:SHALO_RS06935
uniprot id: A0A1D7TJJ0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1193502:SHALO RS10875
gene id: 1193502:SHALO_RS10875
uniprot id: A0A1D7TLT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1193502:SHALO RS07605
gene id: 1193502:SHALO_RS07605
uniprot id: A0A1D7TJU6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1193502:SHALO RS02905
gene id: 1193502:SHALO_RS02905
uniprot id: A0A1D7THA7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1193502:SHALO RS11260
gene id: 1193502:SHALO_RS11260
uniprot id: A0A1D7TLY6
names: Similarity
messages: Belongs to the glycosyltransferase 10 family.

1193502:SHALO RS09965
gene id: 1193502:SHALO_RS09965
uniprot id: A0A1D7TL76
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1193502:SHALO RS06855
gene id: 1193502:SHALO_RS06855
uniprot id: A0A1D7TJG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

1193502:SHALO RS15130
gene id: 1193502:SHALO_RS15130
uniprot id: A0A1D7TP62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1193502:SHALO RS04475
gene id: 1193502:SHALO_RS04475
uniprot id: A0A1D7TI56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

1193502:SHALO RS00525
gene id: 1193502:SHALO_RS00525
uniprot id: A0A1D7TG41
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1193502:SHALO RS10305
gene id: 1193502:SHALO_RS10305
uniprot id: A0A1D7TLF7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1193502:SHALO RS11600
gene id: 1193502:SHALO_RS11600
uniprot id: A0A1D7TM51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1193502:SHALO RS09925
gene id: 1193502:SHALO_RS09925
uniprot id: A0A1D7TL75
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1193502:SHALO RS01970
gene id: 1193502:SHALO_RS01970
uniprot id: A0A1D7TGQ4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1193502:SHALO RS04360
gene id: 1193502:SHALO_RS04360
uniprot id: A0A1D7THZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1193502:SHALO RS00700
gene id: 1193502:SHALO_RS00700
uniprot id: A0A1D7TGC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1193502:SHALO RS07955
gene id: 1193502:SHALO_RS07955
uniprot id: A0A1D7TK27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1193502:SHALO RS02890
gene id: 1193502:SHALO_RS02890
uniprot id: A0A1D7THD6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1193502:SHALO RS11485
gene id: 1193502:SHALO_RS11485
uniprot id: A0A1D7TM19
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1193502:SHALO RS02130
gene id: 1193502:SHALO_RS02130
uniprot id: A0A1D7TGS6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1193502:SHALO RS05155
gene id: 1193502:SHALO_RS05155
uniprot id: A0A1D7TIJ5
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1193502:SHALO RS10740
gene id: 1193502:SHALO_RS10740
uniprot id: A0A1D7TLM8
names: Similarity
messages: Belongs to the peptidase A31 family.

1193502:SHALO RS13925
gene id: 1193502:SHALO_RS13925
uniprot id: A0A1D7TNN0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1193502:SHALO RS10715
gene id: 1193502:SHALO_RS10715
uniprot id: A0A1D7TLM2
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS04810
gene id: 1193502:SHALO_RS04810
uniprot id: A0A1D7TI83
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1193502:SHALO RS00480
gene id: 1193502:SHALO_RS00480
uniprot id: A0A1D7TFW8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1193502:SHALO RS13810
gene id: 1193502:SHALO_RS13810
uniprot id: A0A1D7TNG6
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS10275
gene id: 1193502:SHALO_RS10275
uniprot id: A0A1D7TLF5
names: Similarity
messages: Belongs to the glutamine synthetase family.

1193502:SHALO RS10465
gene id: 1193502:SHALO_RS10465
uniprot id: A0A1D7TLJ7
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS00855
gene id: 1193502:SHALO_RS00855
uniprot id: A0A1D7TG42
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1193502:SHALO RS08870
gene id: 1193502:SHALO_RS08870
uniprot id: A0A1D7TKL3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1193502:SHALO RS06665
gene id: 1193502:SHALO_RS06665
uniprot id: A0A1D7TJB3
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS04550
gene id: 1193502:SHALO_RS04550
uniprot id: A0A1D7TI81
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

1193502:SHALO RS09210
gene id: 1193502:SHALO_RS09210
uniprot id: A0A1D7TKT1
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1193502:SHALO RS01895
gene id: 1193502:SHALO_RS01895
uniprot id: A0A1D7TGV7
names: Similarity
messages: Belongs to the peptidase S49 family.

1193502:SHALO RS10100
gene id: 1193502:SHALO_RS10100
uniprot id: A0A1D7TLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1193502:SHALO RS10270
gene id: 1193502:SHALO_RS10270
uniprot id: A0A1D7TLD5
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1193502:SHALO RS11410
gene id: 1193502:SHALO_RS11410
uniprot id: A0A1D7TM18
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1193502:SHALO RS08105
gene id: 1193502:SHALO_RS08105
uniprot id: A0A1D7TK58
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

1193502:SHALO RS13055
gene id: 1193502:SHALO_RS13055
uniprot id: A0A1D7TN02
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1193502:SHALO RS11085
gene id: 1193502:SHALO_RS11085
uniprot id: A0A1D7TLW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1193502:SHALO RS10865
gene id: 1193502:SHALO_RS10865
uniprot id: A0A1D7TLQ2
names: Similarity
messages: Belongs to the ModE family.

1193502:SHALO RS02990
gene id: 1193502:SHALO_RS02990
uniprot id: A0A1D7THA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1193502:SHALO RS11855
gene id: 1193502:SHALO_RS11855
uniprot id: A0A1D7TM95
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1193502:SHALO RS04030
gene id: 1193502:SHALO_RS04030
uniprot id: A0A1D7THS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1193502:SHALO RS11245
gene id: 1193502:SHALO_RS11245
uniprot id: A0A1D7TLX8
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS01040
gene id: 1193502:SHALO_RS01040
uniprot id: A0A1D7TG55
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1193502:SHALO RS01300
gene id: 1193502:SHALO_RS01300
uniprot id: A0A1D7TGC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1193502:SHALO RS13900
gene id: 1193502:SHALO_RS13900
uniprot id: A0A1D7TNF2
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1193502:SHALO RS00070
gene id: 1193502:SHALO_RS00070
uniprot id: A0A1D7TFP9
names: Similarity
messages: Belongs to the class-I fumarase family.

1193502:SHALO RS01680
gene id: 1193502:SHALO_RS01680
uniprot id: A0A1D7TGL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1193502:SHALO RS07600
gene id: 1193502:SHALO_RS07600
uniprot id: A0A1D7TK45
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1193502:SHALO RS10890
gene id: 1193502:SHALO_RS10890
uniprot id: A0A1D7TLQ6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1193502:SHALO RS10815
gene id: 1193502:SHALO_RS10815
uniprot id: A0A1D7TLP0
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

1193502:SHALO RS11205
gene id: 1193502:SHALO_RS11205
uniprot id: A0A1D7TLX6
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1193502:SHALO RS10080
gene id: 1193502:SHALO_RS10080
uniprot id: A0A1D7TLA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1193502:SHALO RS04365
gene id: 1193502:SHALO_RS04365
uniprot id: A0A1D7TI15
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1193502:SHALO RS12870
gene id: 1193502:SHALO_RS12870
uniprot id: A0A1D7TMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1193502:SHALO RS14530
gene id: 1193502:SHALO_RS14530
uniprot id: A0A1D7TNT5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1193502:SHALO RS01625
gene id: 1193502:SHALO_RS01625
uniprot id: A0A1D7TGH4
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1193502:SHALO RS07290
gene id: 1193502:SHALO_RS07290
uniprot id: A0A1D7TJP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Cell wall formation.
messages: Cytoplasm

1193502:SHALO RS14740
gene id: 1193502:SHALO_RS14740
uniprot id: A0A1D7TNX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1193502:SHALO RS12230
gene id: 1193502:SHALO_RS12230
uniprot id: A0A1D7TMH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1193502:SHALO RS02445
gene id: 1193502:SHALO_RS02445
uniprot id: A0A1D7TGX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1193502:SHALO RS08760
gene id: 1193502:SHALO_RS08760
uniprot id: A0A1D7TKR7
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS03910
gene id: 1193502:SHALO_RS03910
uniprot id: A0A1D7THT3
names: Function
names: Similarity
messages: Belongs to the phage GPA family.
messages: Possible endonuclease which induces a single-strand cut and initiates DNA replication.

1193502:SHALO RS04615
gene id: 1193502:SHALO_RS04615
uniprot id: A0A1D7TI65
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS09600
gene id: 1193502:SHALO_RS09600
uniprot id: A0A1D7TL20
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1193502:SHALO RS01490
gene id: 1193502:SHALO_RS01490
uniprot id: A0A1D7TGG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1193502:SHALO RS12520
gene id: 1193502:SHALO_RS12520
uniprot id: A0A1D7TMP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

1193502:SHALO RS11695
gene id: 1193502:SHALO_RS11695
uniprot id: A0A1D7TM82
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

1193502:SHALO RS01995
gene id: 1193502:SHALO_RS01995
uniprot id: A0A1D7TGX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1193502:SHALO RS00225
gene id: 1193502:SHALO_RS00225
uniprot id: A0A1D7TFT0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1193502:SHALO RS11645
gene id: 1193502:SHALO_RS11645
uniprot id: A0A1D7TM79
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1193502:SHALO RS00980
gene id: 1193502:SHALO_RS00980
uniprot id: A0A1D7TGD0
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS08740
gene id: 1193502:SHALO_RS08740
uniprot id: A0A1D7TKN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

1193502:SHALO RS00050
gene id: 1193502:SHALO_RS00050
uniprot id: A0A1D7TFM5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1193502:SHALO RS01190
gene id: 1193502:SHALO_RS01190
uniprot id: A0A1D7TG88
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS14505
gene id: 1193502:SHALO_RS14505
uniprot id: A0A1D7TNU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS10980
gene id: 1193502:SHALO_RS10980
uniprot id: A0A1D7TLV4
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1193502:SHALO RS03850
gene id: 1193502:SHALO_RS03850
uniprot id: A0A1D7THS4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1193502:SHALO RS02340
gene id: 1193502:SHALO_RS02340
uniprot id: A0A1D7TH14
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS03780
gene id: 1193502:SHALO_RS03780
uniprot id: A0A1D7TI46
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1193502:SHALO RS07915
gene id: 1193502:SHALO_RS07915
uniprot id: A0A1D7TK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS11150
gene id: 1193502:SHALO_RS11150
uniprot id: A0A1D7TM57
names: Caution
names: Similarity
messages: Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS03565
gene id: 1193502:SHALO_RS03565
uniprot id: A0A1D7THR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

1193502:SHALO RS13995
gene id: 1193502:SHALO_RS13995
uniprot id: A0A1D7TNI6
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS09275
gene id: 1193502:SHALO_RS09275
uniprot id: A0A1D7TKV2
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS10280
gene id: 1193502:SHALO_RS10280
uniprot id: A0A1D7TLD7
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

1193502:SHALO RS08510
gene id: 1193502:SHALO_RS08510
uniprot id: A0A1D7TKD9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS08350
gene id: 1193502:SHALO_RS08350
uniprot id: A0A1D7TKA8
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cell membrane
messages: Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.

1193502:SHALO RS12095
gene id: 1193502:SHALO_RS12095
uniprot id: A0A1D7TMD9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1193502:SHALO RS01105
gene id: 1193502:SHALO_RS01105
uniprot id: A0A1D7TG91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1193502:SHALO RS00755
gene id: 1193502:SHALO_RS00755
uniprot id: A0A1D7TG19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS04280
gene id: 1193502:SHALO_RS04280
uniprot id: A0A1D7THW4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1193502:SHALO RS12360
gene id: 1193502:SHALO_RS12360
uniprot id: A0A1D7TMK4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1193502:SHALO RS04845
gene id: 1193502:SHALO_RS04845
uniprot id: A0A1D7TIA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

1193502:SHALO RS10575
gene id: 1193502:SHALO_RS10575
uniprot id: A0A1D7TLK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

1193502:SHALO RS14315
gene id: 1193502:SHALO_RS14315
uniprot id: A0A1D7TNN7
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1193502:SHALO RS03275
gene id: 1193502:SHALO_RS03275
uniprot id: A0A1D7THG3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1193502:SHALO RS02430
gene id: 1193502:SHALO_RS02430
uniprot id: A0A1D7TGZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1193502:SHALO RS08550
gene id: 1193502:SHALO_RS08550
uniprot id: A0A1D7TKE7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS08515
gene id: 1193502:SHALO_RS08515
uniprot id: A0A1D7TKL7
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

1193502:SHALO RS09075
gene id: 1193502:SHALO_RS09075
uniprot id: A0A1D7TKR1
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1193502:SHALO RS10665
gene id: 1193502:SHALO_RS10665
uniprot id: A0A1D7TLQ1
names: Similarity
messages: Belongs to the SUI1 family.

1193502:SHALO RS05675
gene id: 1193502:SHALO_RS05675
uniprot id: A0A1D7TIV5
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

1193502:SHALO RS05990
gene id: 1193502:SHALO_RS05990
uniprot id: A0A1D7TIW6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1193502:SHALO RS04520
gene id: 1193502:SHALO_RS04520
uniprot id: A0A1D7TIA6
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1193502:SHALO RS04425
gene id: 1193502:SHALO_RS04425
uniprot id: A0A1D7TI44
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS01235
gene id: 1193502:SHALO_RS01235
uniprot id: A0A1D7TGH8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1193502:SHALO RS04735
gene id: 1193502:SHALO_RS04735
uniprot id: A0A1D7TIC0
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS03130
gene id: 1193502:SHALO_RS03130
uniprot id: A0A1D7THA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1193502:SHALO RS04980
gene id: 1193502:SHALO_RS04980
uniprot id: A0A1D7TIC2
names: Similarity
messages: Belongs to the MipA/OmpV family.

1193502:SHALO RS03230
gene id: 1193502:SHALO_RS03230
uniprot id: A0A1D7THC2
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS11935
gene id: 1193502:SHALO_RS11935
uniprot id: A0A1D7TMC7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1193502:SHALO RS11385
gene id: 1193502:SHALO_RS11385
uniprot id: A0A1D7TM23
names: Cofactor
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1193502:SHALO RS12170
gene id: 1193502:SHALO_RS12170
uniprot id: A0A1D7TMP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1193502:SHALO RS13520
gene id: 1193502:SHALO_RS13520
uniprot id: A0A1D7TN92
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1193502:SHALO RS15025
gene id: 1193502:SHALO_RS15025
uniprot id: A0A1D7TP21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1193502:SHALO RS07200
gene id: 1193502:SHALO_RS07200
uniprot id: A0A1D7TJL1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1193502:SHALO RS00460
gene id: 1193502:SHALO_RS00460
uniprot id: A0A1D7TFX4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00905
gene id: 1193502:SHALO_RS00905
uniprot id: A0A1D7TG51
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1193502:SHALO RS12755
gene id: 1193502:SHALO_RS12755
uniprot id: A0A1D7TMT8
names: Similarity
messages: Belongs to the UPF0751 family.

1193502:SHALO RS01345
gene id: 1193502:SHALO_RS01345
uniprot id: A0A1D7TGC3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1193502:SHALO RS03340
gene id: 1193502:SHALO_RS03340
uniprot id: A0A1D7THD9
names: Similarity
messages: Belongs to the MQO family.

1193502:SHALO RS11875
gene id: 1193502:SHALO_RS11875
uniprot id: A0A1D7TMC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS03325
gene id: 1193502:SHALO_RS03325
uniprot id: A0A1D7THC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1193502:SHALO RS06745
gene id: 1193502:SHALO_RS06745
uniprot id: A0A1D7TJB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS01835
gene id: 1193502:SHALO_RS01835
uniprot id: A0A1D7TGP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1193502:SHALO RS10050
gene id: 1193502:SHALO_RS10050
uniprot id: A0A1D7TLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1193502:SHALO RS03450
gene id: 1193502:SHALO_RS03450
uniprot id: A0A1D7THK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS13310
gene id: 1193502:SHALO_RS13310
uniprot id: A0A1D7TN59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

1193502:SHALO RS06190
gene id: 1193502:SHALO_RS06190
uniprot id: A0A1D7TJ10
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS11000
gene id: 1193502:SHALO_RS11000
uniprot id: A0A1D7TM25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1193502:SHALO RS08115
gene id: 1193502:SHALO_RS08115
uniprot id: A0A1D7TK62
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Hexamer of two alpha, two beta, and two delta chains.

1193502:SHALO RS08295
gene id: 1193502:SHALO_RS08295
uniprot id: A0A1D7TK93
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

1193502:SHALO RS00145
gene id: 1193502:SHALO_RS00145
uniprot id: A0A1D7TFX1
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS04135
gene id: 1193502:SHALO_RS04135
uniprot id: A0A1D7TIB3
names: Function
names: Similarity
messages: Belongs to the CowN family.
messages: Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.

1193502:SHALO RS13385
gene id: 1193502:SHALO_RS13385
uniprot id: A0A1D7TN62
names: Similarity
messages: Belongs to the ModE family.

1193502:SHALO RS10245
gene id: 1193502:SHALO_RS10245
uniprot id: A0A1D7TLG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1193502:SHALO RS08445
gene id: 1193502:SHALO_RS08445
uniprot id: A0A1D7TKH6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS10580
gene id: 1193502:SHALO_RS10580
uniprot id: A0A1D7TLT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1193502:SHALO RS12760
gene id: 1193502:SHALO_RS12760
uniprot id: A0A1D7TMU6
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1193502:SHALO RS14760
gene id: 1193502:SHALO_RS14760
uniprot id: A0A1D7TNW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1193502:SHALO RS08005
gene id: 1193502:SHALO_RS08005
uniprot id: A0A1D7TK40
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS00820
gene id: 1193502:SHALO_RS00820
uniprot id: A0A1D7TG09
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS04895
gene id: 1193502:SHALO_RS04895
uniprot id: A0A1D7TIA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1193502:SHALO RS03775
gene id: 1193502:SHALO_RS03775
uniprot id: A0A1D7THS8
names: Similarity
messages: Belongs to the GSP E family.

1193502:SHALO RS09325
gene id: 1193502:SHALO_RS09325
uniprot id: A0A1D7TKW1
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

1193502:SHALO RS03010
gene id: 1193502:SHALO_RS03010
uniprot id: A0A1D7TH84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1193502:SHALO RS02225
gene id: 1193502:SHALO_RS02225
uniprot id: A0A1D7TGW4
names: Similarity
messages: Belongs to the DDAH family.

1193502:SHALO RS02850
gene id: 1193502:SHALO_RS02850
uniprot id: A0A1D7TH50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1193502:SHALO RS10495
gene id: 1193502:SHALO_RS10495
uniprot id: A0A1D7TLH7
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS12155
gene id: 1193502:SHALO_RS12155
uniprot id: A0A1D7TMG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1193502:SHALO RS00025
gene id: 1193502:SHALO_RS00025
uniprot id: A0A1D7TFQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

1193502:SHALO RS08425
gene id: 1193502:SHALO_RS08425
uniprot id: A0A1D7TKD4
names: Similarity
messages: Belongs to the UbiD family.

1193502:SHALO RS09090
gene id: 1193502:SHALO_RS09090
uniprot id: A0A1D7TKQ4
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1193502:SHALO RS09475
gene id: 1193502:SHALO_RS09475
uniprot id: A0A1D7TKZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS12550
gene id: 1193502:SHALO_RS12550
uniprot id: A0A1D7TMN1
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

1193502:SHALO RS00685
gene id: 1193502:SHALO_RS00685
uniprot id: A0A1D7TG13
names: Similarity
messages: Belongs to the UPF0234 family.

1193502:SHALO RS12985
gene id: 1193502:SHALO_RS12985
uniprot id: A0A1D7TMX1
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1193502:SHALO RS02780
gene id: 1193502:SHALO_RS02780
uniprot id: A0A1D7TH25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1193502:SHALO RS08850
gene id: 1193502:SHALO_RS08850
uniprot id: A0A1D7TKK8
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1193502:SHALO RS02685
gene id: 1193502:SHALO_RS02685
uniprot id: A0A1D7TH31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
messages: Monomer.

1193502:SHALO RS08855
gene id: 1193502:SHALO_RS08855
uniprot id: A0A1D7TKK9
names: Similarity
messages: Belongs to the peptidase S41A family.

1193502:SHALO RS08210
gene id: 1193502:SHALO_RS08210
uniprot id: A0A1D7TKG5
names: Similarity
messages: Belongs to the LarC family.

1193502:SHALO RS08140
gene id: 1193502:SHALO_RS08140
uniprot id: A0A1D7TKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1193502:SHALO RS02665
gene id: 1193502:SHALO_RS02665
uniprot id: A0A1D7TH20
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1193502:SHALO RS05025
gene id: 1193502:SHALO_RS05025
uniprot id: A0A1D7TIG7
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1193502:SHALO RS05560
gene id: 1193502:SHALO_RS05560
uniprot id: A0A1D7TIT2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS12305
gene id: 1193502:SHALO_RS12305
uniprot id: A0A1D7TMI6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1193502:SHALO RS01000
gene id: 1193502:SHALO_RS01000
uniprot id: A0A1D7TGJ8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1193502:SHALO RS07330
gene id: 1193502:SHALO_RS07330
uniprot id: A0A1D7TJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1193502:SHALO RS02845
gene id: 1193502:SHALO_RS02845
uniprot id: A0A1D7TH79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1193502:SHALO RS14755
gene id: 1193502:SHALO_RS14755
uniprot id: A0A1D7TNZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1193502:SHALO RS13005
gene id: 1193502:SHALO_RS13005
uniprot id: A0A1D7TMY8
names: Subcellular Location Annotation
messages: Secreted

1193502:SHALO RS05010
gene id: 1193502:SHALO_RS05010
uniprot id: A0A1D7TIC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1193502:SHALO RS12110
gene id: 1193502:SHALO_RS12110
uniprot id: A0A1D7TMF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1193502:SHALO RS14555
gene id: 1193502:SHALO_RS14555
uniprot id: A0A1D7TNV4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS06115
gene id: 1193502:SHALO_RS06115
uniprot id: A0A1D7TJ89
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1193502:SHALO RS04655
gene id: 1193502:SHALO_RS04655
uniprot id: A0A1D7TI88
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS00850
gene id: 1193502:SHALO_RS00850
uniprot id: A0A1D7TGG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS10385
gene id: 1193502:SHALO_RS10385
uniprot id: A0A1D7TLG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1193502:SHALO RS13375
gene id: 1193502:SHALO_RS13375
uniprot id: A0A1D7TN63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1193502:SHALO RS04055
gene id: 1193502:SHALO_RS04055
uniprot id: A0A1D7THW5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1193502:SHALO RS08835
gene id: 1193502:SHALO_RS08835
uniprot id: A0A1D7TKK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1193502:SHALO RS05995
gene id: 1193502:SHALO_RS05995
uniprot id: A0A1D7TJ15
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1193502:SHALO RS01095
gene id: 1193502:SHALO_RS01095
uniprot id: A0A1D7TG77
names: Similarity
messages: Belongs to the thioredoxin family.

1193502:SHALO RS10910
gene id: 1193502:SHALO_RS10910
uniprot id: A0A1D7TLQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

1193502:SHALO RS12640
gene id: 1193502:SHALO_RS12640
uniprot id: A0A1D7TMQ0
names: Similarity
messages: Belongs to the FeoA family.

1193502:SHALO RS07700
gene id: 1193502:SHALO_RS07700
uniprot id: A0A1D7TK72
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS12260
gene id: 1193502:SHALO_RS12260
uniprot id: A0A1D7TMI2
names: Similarity
messages: Belongs to the UPF0423 family.

1193502:SHALO RS10790
gene id: 1193502:SHALO_RS10790
uniprot id: A0A1D7TLN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1193502:SHALO RS14535
gene id: 1193502:SHALO_RS14535
uniprot id: A0A1D7TNR9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1193502:SHALO RS03135
gene id: 1193502:SHALO_RS03135
uniprot id: A0A1D7THC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1193502:SHALO RS12250
gene id: 1193502:SHALO_RS12250
uniprot id: A0A1D7TMJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1193502:SHALO RS13945
gene id: 1193502:SHALO_RS13945
uniprot id: A0A1D7TNF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1193502:SHALO RS11010
gene id: 1193502:SHALO_RS11010
uniprot id: A0A1D7TLU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1193502:SHALO RS04755
gene id: 1193502:SHALO_RS04755
uniprot id: A0A1D7TIB0
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS12140
gene id: 1193502:SHALO_RS12140
uniprot id: A0A1D7TMF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1193502:SHALO RS09765
gene id: 1193502:SHALO_RS09765
uniprot id: A0A1D7TLC3
names: Similarity
messages: Belongs to the YjdM family.

1193502:SHALO RS07520
gene id: 1193502:SHALO_RS07520
uniprot id: A0A1D7TJS2
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1193502:SHALO RS08995
gene id: 1193502:SHALO_RS08995
uniprot id: A0A1D7TKS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1193502:SHALO RS08480
gene id: 1193502:SHALO_RS08480
uniprot id: A0A1D7TKD7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1193502:SHALO RS08685
gene id: 1193502:SHALO_RS08685
uniprot id: A0A1D7TKG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS11195
gene id: 1193502:SHALO_RS11195
uniprot id: A0A1D7TLW6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1193502:SHALO RS06095
gene id: 1193502:SHALO_RS06095
uniprot id: A0A1D7TJ32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterioferritin family.
messages: Cytoplasm
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

1193502:SHALO RS07025
gene id: 1193502:SHALO_RS07025
uniprot id: A0A1D7TJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1193502:SHALO RS11915
gene id: 1193502:SHALO_RS11915
uniprot id: A0A1D7TMB1
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1193502:SHALO RS07705
gene id: 1193502:SHALO_RS07705
uniprot id: A0A1D7TJX9
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.

1193502:SHALO RS11415
gene id: 1193502:SHALO_RS11415
uniprot id: A0A1D7TM14
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1193502:SHALO RS11605
gene id: 1193502:SHALO_RS11605
uniprot id: A0A1D7TM49
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS04025
gene id: 1193502:SHALO_RS04025
uniprot id: A0A1D7THW1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1193502:SHALO RS10220
gene id: 1193502:SHALO_RS10220
uniprot id: A0A1D7TLC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm

1193502:SHALO RS08800
gene id: 1193502:SHALO_RS08800
uniprot id: A0A1D7TKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1193502:SHALO RS01005
gene id: 1193502:SHALO_RS01005
uniprot id: A0A1D7TG73
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1193502:SHALO RS15100
gene id: 1193502:SHALO_RS15100
uniprot id: A0A1D7TP83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1193502:SHALO RS14705
gene id: 1193502:SHALO_RS14705
uniprot id: A0A1D7TNY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1193502:SHALO RS14225
gene id: 1193502:SHALO_RS14225
uniprot id: A0A1D7TNK8
names: Subcellular Location Annotation
messages: Cell inner membrane

1193502:SHALO RS03695
gene id: 1193502:SHALO_RS03695
uniprot id: A0A1D7THQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1193502:SHALO RS09545
gene id: 1193502:SHALO_RS09545
uniprot id: A0A1D7TL32
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1193502:SHALO RS03395
gene id: 1193502:SHALO_RS03395
uniprot id: A0A1D7THK8
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1193502:SHALO RS06755
gene id: 1193502:SHALO_RS06755
uniprot id: A0A1D7TJE7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1193502:SHALO RS03050
gene id: 1193502:SHALO_RS03050
uniprot id: A0A1D7THE0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1193502:SHALO RS10375
gene id: 1193502:SHALO_RS10375
uniprot id: A0A1D7TLG4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1193502:SHALO RS09400
gene id: 1193502:SHALO_RS09400
uniprot id: A0A1D7TKX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1193502:SHALO RS13910
gene id: 1193502:SHALO_RS13910
uniprot id: A0A1D7TNF3
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.

1193502:SHALO RS04415
gene id: 1193502:SHALO_RS04415
uniprot id: A0A1D7TI26
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS14205
gene id: 1193502:SHALO_RS14205
uniprot id: A0A1D7TNT0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1193502:SHALO RS09650
gene id: 1193502:SHALO_RS09650
uniprot id: A0A1D7TL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS10930
gene id: 1193502:SHALO_RS10930
uniprot id: A0A1D7TLU7
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

1193502:SHALO RS01705
gene id: 1193502:SHALO_RS01705
uniprot id: A0A1D7TGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1193502:SHALO RS11900
gene id: 1193502:SHALO_RS11900
uniprot id: A0A1D7TMC3
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS14345
gene id: 1193502:SHALO_RS14345
uniprot id: A0A1D7TNN6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1193502:SHALO RS12965
gene id: 1193502:SHALO_RS12965
uniprot id: A0A1D7TN47
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

1193502:SHALO RS14805
gene id: 1193502:SHALO_RS14805
uniprot id: A0A1D7TP08
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

1193502:SHALO RS13060
gene id: 1193502:SHALO_RS13060
uniprot id: A0A1D7TN08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

1193502:SHALO RS01290
gene id: 1193502:SHALO_RS01290
uniprot id: A0A1D7TGC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1193502:SHALO RS09825
gene id: 1193502:SHALO_RS09825
uniprot id: A0A1D7TL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1193502:SHALO RS02575
gene id: 1193502:SHALO_RS02575
uniprot id: A0A1D7TH32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1193502:SHALO RS08565
gene id: 1193502:SHALO_RS08565
uniprot id: A0A1D7TKM8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS06740
gene id: 1193502:SHALO_RS06740
uniprot id: A0A1D7TJP7
names: Similarity
messages: Belongs to the MotB family.

1193502:SHALO RS05690
gene id: 1193502:SHALO_RS05690
uniprot id: A0A1D7TIR7
names: Similarity
messages: Belongs to the DprA/Smf family.

1193502:SHALO RS01475
gene id: 1193502:SHALO_RS01475
uniprot id: A0A1D7TGE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1193502:SHALO RS06005
gene id: 1193502:SHALO_RS06005
uniprot id: A0A1D7TIW7
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1193502:SHALO RS13160
gene id: 1193502:SHALO_RS13160
uniprot id: A0A1D7TN24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multiheme cytochrome c family.
messages: Binds 8 heme c groups covalently per monomer.
messages: Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.
messages: Periplasm
messages: Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process.

1193502:SHALO RS07285
gene id: 1193502:SHALO_RS07285
uniprot id: A0A1D7TJP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1193502:SHALO RS13935
gene id: 1193502:SHALO_RS13935
uniprot id: A0A1D7TNG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1193502:SHALO RS12060
gene id: 1193502:SHALO_RS12060
uniprot id: A0A1D7TME5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1193502:SHALO RS10065
gene id: 1193502:SHALO_RS10065
uniprot id: A0A1D7TLH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Membrane

1193502:SHALO RS13305
gene id: 1193502:SHALO_RS13305
uniprot id: A0A1D7TN51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1193502:SHALO RS06395
gene id: 1193502:SHALO_RS06395
uniprot id: A0A1D7TJ51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1193502:SHALO RS02550
gene id: 1193502:SHALO_RS02550
uniprot id: A0A1D7TGZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1193502:SHALO RS13380
gene id: 1193502:SHALO_RS13380
uniprot id: A0A1D7TN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS15150
gene id: 1193502:SHALO_RS15150
uniprot id: A0A1D7TP93
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1193502:SHALO RS13280
gene id: 1193502:SHALO_RS13280
uniprot id: A0A1D7TN43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1193502:SHALO RS14595
gene id: 1193502:SHALO_RS14595
uniprot id: A0A1D7TNX1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1193502:SHALO RS07930
gene id: 1193502:SHALO_RS07930
uniprot id: A0A1D7TK16
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

1193502:SHALO RS13930
gene id: 1193502:SHALO_RS13930
uniprot id: A0A1D7TNH5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1193502:SHALO RS08070
gene id: 1193502:SHALO_RS08070
uniprot id: A0A1D7TK65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1193502:SHALO RS01355
gene id: 1193502:SHALO_RS01355
uniprot id: A0A1D7TGS3
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1193502:SHALO RS12045
gene id: 1193502:SHALO_RS12045
uniprot id: A0A1D7TMD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1193502:SHALO RS01275
gene id: 1193502:SHALO_RS01275
uniprot id: A0A1D7TGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1193502:SHALO RS13120
gene id: 1193502:SHALO_RS13120
uniprot id: A0A1D7TN19
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS05965
gene id: 1193502:SHALO_RS05965
uniprot id: A0A1D7TJ54
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1193502:SHALO RS08975
gene id: 1193502:SHALO_RS08975
uniprot id: A0A1D7TKP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1193502:SHALO RS01160
gene id: 1193502:SHALO_RS01160
uniprot id: A0A1D7TG97
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1193502:SHALO RS03190
gene id: 1193502:SHALO_RS03190
uniprot id: A0A1D7THJ5
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS11135
gene id: 1193502:SHALO_RS11135
uniprot id: A0A1D7TLX7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1193502:SHALO RS09405
gene id: 1193502:SHALO_RS09405
uniprot id: A0A1D7TKX8
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1193502:SHALO RS13290
gene id: 1193502:SHALO_RS13290
uniprot id: A0A1D7TN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1193502:SHALO RS14825
gene id: 1193502:SHALO_RS14825
uniprot id: A0A1D7TP47
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1193502:SHALO RS02960
gene id: 1193502:SHALO_RS02960
uniprot id: A0A1D7TH74
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1193502:SHALO RS11335
gene id: 1193502:SHALO_RS11335
uniprot id: A0A1D7TM12
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS02420
gene id: 1193502:SHALO_RS02420
uniprot id: A0A1D7TGZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1193502:SHALO RS07055
gene id: 1193502:SHALO_RS07055
uniprot id: A0A1D7TJK6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1193502:SHALO RS02320
gene id: 1193502:SHALO_RS02320
uniprot id: A0A1D7TGV9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1193502:SHALO RS00140
gene id: 1193502:SHALO_RS00140
uniprot id: A0A1D7TFR5
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1193502:SHALO RS10295
gene id: 1193502:SHALO_RS10295
uniprot id: A0A1D7TLH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1193502:SHALO RS07415
gene id: 1193502:SHALO_RS07415
uniprot id: A0A1D7TJR2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS02055
gene id: 1193502:SHALO_RS02055
uniprot id: A0A1D7TGR1
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1193502:SHALO RS05760
gene id: 1193502:SHALO_RS05760
uniprot id: A0A1D7TIX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1193502:SHALO RS08265
gene id: 1193502:SHALO_RS08265
uniprot id: A0A1D7TK90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerH subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1193502:SHALO RS08720
gene id: 1193502:SHALO_RS08720
uniprot id: A0A1D7TKJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1193502:SHALO RS02760
gene id: 1193502:SHALO_RS02760
uniprot id: A0A1D7THL8
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1193502:SHALO RS14585
gene id: 1193502:SHALO_RS14585
uniprot id: A0A1D7TNS8
names: Subcellular Location Annotation
messages: Secreted

1193502:SHALO RS11160
gene id: 1193502:SHALO_RS11160
uniprot id: A0A1D7TLX2
names: Similarity
messages: Belongs to the TPP enzyme family.

1193502:SHALO RS06120
gene id: 1193502:SHALO_RS06120
uniprot id: A0A1D7TJ21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifW family.
messages: Homotrimer; associates with NifD.
messages: May protect the nitrogenase Fe-Mo protein from oxidative damage.

1193502:SHALO RS14100
gene id: 1193502:SHALO_RS14100
uniprot id: A0A1D7TNR4
names: Similarity
messages: Belongs to the FrmR/RcnR family.

1193502:SHALO RS03425
gene id: 1193502:SHALO_RS03425
uniprot id: A0A1D7THF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1193502:SHALO RS03655
gene id: 1193502:SHALO_RS03655
uniprot id: A0A1D7THN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

1193502:SHALO RS11500
gene id: 1193502:SHALO_RS11500
uniprot id: A0A1D7TM27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1193502:SHALO RS04270
gene id: 1193502:SHALO_RS04270
uniprot id: A0A1D7TI63
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS02450
gene id: 1193502:SHALO_RS02450
uniprot id: A0A1D7TH07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1193502:SHALO RS08145
gene id: 1193502:SHALO_RS08145
uniprot id: A0A1D7TK56
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00075
gene id: 1193502:SHALO_RS00075
uniprot id: A0A1D7TFM7
names: Similarity
messages: Belongs to the class-I fumarase family.

1193502:SHALO RS09750
gene id: 1193502:SHALO_RS09750
uniprot id: A0A1D7TL48
names: Similarity
messages: Belongs to the citrate synthase family.

1193502:SHALO RS04800
gene id: 1193502:SHALO_RS04800
uniprot id: A0A1D7TIC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

1193502:SHALO RS01055
gene id: 1193502:SHALO_RS01055
uniprot id: A0A1D7TG83
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1193502:SHALO RS03845
gene id: 1193502:SHALO_RS03845
uniprot id: A0A1D7THN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

1193502:SHALO RS07430
gene id: 1193502:SHALO_RS07430
uniprot id: A0A1D7TJR1
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1193502:SHALO RS09935
gene id: 1193502:SHALO_RS09935
uniprot id: A0A1D7TL68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1193502:SHALO RS01390
gene id: 1193502:SHALO_RS01390
uniprot id: A0A1D7TGE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1193502:SHALO RS12435
gene id: 1193502:SHALO_RS12435
uniprot id: A0A1D7TML0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

1193502:SHALO RS09365
gene id: 1193502:SHALO_RS09365
uniprot id: A0A1D7TL34
names: Similarity
messages: Belongs to the FrmR/RcnR family.

1193502:SHALO RS13895
gene id: 1193502:SHALO_RS13895
uniprot id: A0A1D7TNE9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1193502:SHALO RS02570
gene id: 1193502:SHALO_RS02570
uniprot id: A0A1D7TH46
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS00185
gene id: 1193502:SHALO_RS00185
uniprot id: A0A1D7TFQ2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1193502:SHALO RS01910
gene id: 1193502:SHALO_RS01910
uniprot id: A0A1D7TGP6
names: Similarity
messages: Belongs to the peptidase M24B family.

1193502:SHALO RS14360
gene id: 1193502:SHALO_RS14360
uniprot id: A0A1D7TNQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS03415
gene id: 1193502:SHALO_RS03415
uniprot id: A0A1D7THN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

1193502:SHALO RS07015
gene id: 1193502:SHALO_RS07015
uniprot id: A0A1D7TJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1193502:SHALO RS09025
gene id: 1193502:SHALO_RS09025
uniprot id: A0A1D7TKQ2
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1193502:SHALO RS10070
gene id: 1193502:SHALO_RS10070
uniprot id: A0A1D7TL92
names: Similarity
messages: Belongs to the AdoMet synthase family.

1193502:SHALO RS07050
gene id: 1193502:SHALO_RS07050
uniprot id: A0A1D7TJM1
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1193502:SHALO RS06385
gene id: 1193502:SHALO_RS06385
uniprot id: A0A1D7TJ86
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Homodimer.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.

1193502:SHALO RS10045
gene id: 1193502:SHALO_RS10045
uniprot id: A0A1D7TLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1193502:SHALO RS10510
gene id: 1193502:SHALO_RS10510
uniprot id: A0A1D7TLM4
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

1193502:SHALO RS05045
gene id: 1193502:SHALO_RS05045
uniprot id: A0A1D7TID6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1193502:SHALO RS06090
gene id: 1193502:SHALO_RS06090
uniprot id: A0A1D7TIY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1193502:SHALO RS10800
gene id: 1193502:SHALO_RS10800
uniprot id: A0A1D7TLP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS07420
gene id: 1193502:SHALO_RS07420
uniprot id: A0A1D7TJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1193502:SHALO RS09125
gene id: 1193502:SHALO_RS09125
uniprot id: A0A1D7TKS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1193502:SHALO RS13725
gene id: 1193502:SHALO_RS13725
uniprot id: A0A1D7TND4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1193502:SHALO RS07235
gene id: 1193502:SHALO_RS07235
uniprot id: A0A1D7TJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1193502:SHALO RS12150
gene id: 1193502:SHALO_RS12150
uniprot id: A0A1D7TMI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1193502:SHALO RS10200
gene id: 1193502:SHALO_RS10200
uniprot id: A0A1D7TLF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1193502:SHALO RS11895
gene id: 1193502:SHALO_RS11895
uniprot id: A0A1D7TM99
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS12055
gene id: 1193502:SHALO_RS12055
uniprot id: A0A1D7TME1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1193502:SHALO RS13265
gene id: 1193502:SHALO_RS13265
uniprot id: A0A1D7TNA2
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS09000
gene id: 1193502:SHALO_RS09000
uniprot id: A0A1D7TKN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS05750
gene id: 1193502:SHALO_RS05750
uniprot id: A0A1D7TIV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1193502:SHALO RS12325
gene id: 1193502:SHALO_RS12325
uniprot id: A0A1D7TMK5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1193502:SHALO RS04730
gene id: 1193502:SHALO_RS04730
uniprot id: A0A1D7TI69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

1193502:SHALO RS01565
gene id: 1193502:SHALO_RS01565
uniprot id: A0A1D7TGI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1193502:SHALO RS07115
gene id: 1193502:SHALO_RS07115
uniprot id: A0A1D7TJK0
names: Similarity
messages: Belongs to the HypE family.

1193502:SHALO RS06340
gene id: 1193502:SHALO_RS06340
uniprot id: A0A1D7TJH9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS04325
gene id: 1193502:SHALO_RS04325
uniprot id: A0A1D7TI24
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS05715
gene id: 1193502:SHALO_RS05715
uniprot id: A0A1D7TJ74
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1193502:SHALO RS04175
gene id: 1193502:SHALO_RS04175
uniprot id: A0A1D7THU9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1193502:SHALO RS14590
gene id: 1193502:SHALO_RS14590
uniprot id: A0A1D7TNT4
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1193502:SHALO RS02655
gene id: 1193502:SHALO_RS02655
uniprot id: A0A1D7TH58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS11035
gene id: 1193502:SHALO_RS11035
uniprot id: A0A1D7TLV6
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1193502:SHALO RS12225
gene id: 1193502:SHALO_RS12225
uniprot id: A0A1D7TMI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1193502:SHALO RS13450
gene id: 1193502:SHALO_RS13450
uniprot id: A0A1D7TN90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

1193502:SHALO RS07215
gene id: 1193502:SHALO_RS07215
uniprot id: A0A1D7TJK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS11435
gene id: 1193502:SHALO_RS11435
uniprot id: A0A1D7TM33
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS05755
gene id: 1193502:SHALO_RS05755
uniprot id: A0A1D7TIR9
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1193502:SHALO RS10750
gene id: 1193502:SHALO_RS10750
uniprot id: A0A1D7TLN2
names: Similarity
messages: Belongs to the AOR/FOR family.

1193502:SHALO RS03330
gene id: 1193502:SHALO_RS03330
uniprot id: A0A1D7THI4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

1193502:SHALO RS03710
gene id: 1193502:SHALO_RS03710
uniprot id: A0A1D7THU5
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1193502:SHALO RS12125
gene id: 1193502:SHALO_RS12125
uniprot id: A0A1D7TMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1193502:SHALO RS09015
gene id: 1193502:SHALO_RS09015
uniprot id: A0A1D7TKW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1193502:SHALO RS00580
gene id: 1193502:SHALO_RS00580
uniprot id: A0A1D7TFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1193502:SHALO RS08530
gene id: 1193502:SHALO_RS08530
uniprot id: A0A1D7TKF0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1193502:SHALO RS02205
gene id: 1193502:SHALO_RS02205
uniprot id: A0A1D7TGW1
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

1193502:SHALO RS02140
gene id: 1193502:SHALO_RS02140
uniprot id: A0A1D7TGU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

1193502:SHALO RS07150
gene id: 1193502:SHALO_RS07150
uniprot id: A0A1D7TJP5
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1193502:SHALO RS01915
gene id: 1193502:SHALO_RS01915
uniprot id: A0A1D7TH51
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1193502:SHALO RS12955
gene id: 1193502:SHALO_RS12955
uniprot id: A0A1D7TMX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1193502:SHALO RS04540
gene id: 1193502:SHALO_RS04540
uniprot id: A0A1D7TII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS04485
gene id: 1193502:SHALO_RS04485
uniprot id: A0A1D7TI71
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS08590
gene id: 1193502:SHALO_RS08590
uniprot id: A0A1D7TKF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1193502:SHALO RS05680
gene id: 1193502:SHALO_RS05680
uniprot id: A0A1D7TIT8
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

1193502:SHALO RS12860
gene id: 1193502:SHALO_RS12860
uniprot id: A0A1D7TMW5
names: Similarity
messages: Belongs to the ArsC family.

1193502:SHALO RS12180
gene id: 1193502:SHALO_RS12180
uniprot id: A0A1D7TMF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1193502:SHALO RS07885
gene id: 1193502:SHALO_RS07885
uniprot id: A0A1D7TK07
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

1193502:SHALO RS02435
gene id: 1193502:SHALO_RS02435
uniprot id: A0A1D7TH44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1193502:SHALO RS13820
gene id: 1193502:SHALO_RS13820
uniprot id: A0A1D7TNF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1193502:SHALO RS09715
gene id: 1193502:SHALO_RS09715
uniprot id: A0A1D7TLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1193502:SHALO RS02910
gene id: 1193502:SHALO_RS02910
uniprot id: A0A1D7THQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS00960
gene id: 1193502:SHALO_RS00960
uniprot id: A0A1D7TG61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1193502:SHALO RS04910
gene id: 1193502:SHALO_RS04910
uniprot id: A0A1D7TIA4
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS04950
gene id: 1193502:SHALO_RS04950
uniprot id: A0A1D7TIG2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1193502:SHALO RS01085
gene id: 1193502:SHALO_RS01085
uniprot id: A0A1D7TG85
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1193502:SHALO RS08885
gene id: 1193502:SHALO_RS08885
uniprot id: A0A1D7TKL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1193502:SHALO RS05230
gene id: 1193502:SHALO_RS05230
uniprot id: A0A1D7TIJ9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1193502:SHALO RS00065
gene id: 1193502:SHALO_RS00065
uniprot id: A0A1D7TFP8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS02755
gene id: 1193502:SHALO_RS02755
uniprot id: A0A1D7TH78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS09140
gene id: 1193502:SHALO_RS09140
uniprot id: A0A1D7TKR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1193502:SHALO RS14735
gene id: 1193502:SHALO_RS14735
uniprot id: A0A1D7TNW5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1193502:SHALO RS11715
gene id: 1193502:SHALO_RS11715
uniprot id: A0A1D7TMG3
names: Similarity
messages: Belongs to the hemerythrin family.

1193502:SHALO RS12075
gene id: 1193502:SHALO_RS12075
uniprot id: A0A1D7TMG1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1193502:SHALO RS00005
gene id: 1193502:SHALO_RS00005
uniprot id: A0A1D7TFN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1193502:SHALO RS08220
gene id: 1193502:SHALO_RS08220
uniprot id: A0A1D7TKA0
names: Similarity
messages: Belongs to the class-I fumarase family.

1193502:SHALO RS12635
gene id: 1193502:SHALO_RS12635
uniprot id: A0A1D7TMQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1193502:SHALO RS13960
gene id: 1193502:SHALO_RS13960
uniprot id: A0A1D7TNG2
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS02615
gene id: 1193502:SHALO_RS02615
uniprot id: A0A1D7TH10
names: Similarity
messages: Belongs to the YkuD family.

1193502:SHALO RS11270
gene id: 1193502:SHALO_RS11270
uniprot id: A0A1D7TLY9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

1193502:SHALO RS11575
gene id: 1193502:SHALO_RS11575
uniprot id: A0A1D7TM39
names: Similarity
messages: Belongs to the UPF0178 family.

1193502:SHALO RS14085
gene id: 1193502:SHALO_RS14085
uniprot id: A0A1D7TNI3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1193502:SHALO RS10870
gene id: 1193502:SHALO_RS10870
uniprot id: A0A1D7TLQ4
names: Similarity
messages: Belongs to the peptidase S11 family.

1193502:SHALO RS11850
gene id: 1193502:SHALO_RS11850
uniprot id: A0A1D7TMB3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS10850
gene id: 1193502:SHALO_RS10850
uniprot id: A0A1D7TLP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1193502:SHALO RS09985
gene id: 1193502:SHALO_RS09985
uniprot id: A0A1D7TL78
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS08280
gene id: 1193502:SHALO_RS08280
uniprot id: A0A1D7TK97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

1193502:SHALO RS00830
gene id: 1193502:SHALO_RS00830
uniprot id: A0A1D7TG98
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS03760
gene id: 1193502:SHALO_RS03760
uniprot id: A0A1D7THV6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS13525
gene id: 1193502:SHALO_RS13525
uniprot id: A0A1D7TN98
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1193502:SHALO RS02015
gene id: 1193502:SHALO_RS02015
uniprot id: A0A1D7TH72
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1193502:SHALO RS10240
gene id: 1193502:SHALO_RS10240
uniprot id: A0A1D7TLD2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1193502:SHALO RS02395
gene id: 1193502:SHALO_RS02395
uniprot id: A0A1D7TH00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1193502:SHALO RS11985
gene id: 1193502:SHALO_RS11985
uniprot id: A0A1D7TMD7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

1193502:SHALO RS07090
gene id: 1193502:SHALO_RS07090
uniprot id: A0A1D7TJW0
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06650
gene id: 1193502:SHALO_RS06650
uniprot id: A0A1D7TJD0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1193502:SHALO RS01100
gene id: 1193502:SHALO_RS01100
uniprot id: A0A1D7TGL6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

1193502:SHALO RS09690
gene id: 1193502:SHALO_RS09690
uniprot id: A0A1D7TL21
names: Similarity
messages: Belongs to the DEAD box helicase family.

1193502:SHALO RS14720
gene id: 1193502:SHALO_RS14720
uniprot id: A0A1D7TNX0
names: Similarity
messages: Belongs to the citrate synthase family.

1193502:SHALO RS05695
gene id: 1193502:SHALO_RS05695
uniprot id: A0A1D7TIZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS14155
gene id: 1193502:SHALO_RS14155
uniprot id: A0A1D7TNK9
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS07655
gene id: 1193502:SHALO_RS07655
uniprot id: A0A1D7TJW7
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1193502:SHALO RS11770
gene id: 1193502:SHALO_RS11770
uniprot id: A0A1D7TMH0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS02290
gene id: 1193502:SHALO_RS02290
uniprot id: A0A1D7TGY0
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

1193502:SHALO RS10015
gene id: 1193502:SHALO_RS10015
uniprot id: A0A1D7TLG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1193502:SHALO RS00965
gene id: 1193502:SHALO_RS00965
uniprot id: A0A1D7TG74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS10600
gene id: 1193502:SHALO_RS10600
uniprot id: A0A1D7TLJ6
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

1193502:SHALO RS10120
gene id: 1193502:SHALO_RS10120
uniprot id: A0A1D7TLA4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1193502:SHALO RS08365
gene id: 1193502:SHALO_RS08365
uniprot id: A0A1D7TKJ3
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1193502:SHALO RS08715
gene id: 1193502:SHALO_RS08715
uniprot id: A0A1D7TKI3
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

1193502:SHALO RS08495
gene id: 1193502:SHALO_RS08495
uniprot id: A0A1D7TKI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

1193502:SHALO RS12315
gene id: 1193502:SHALO_RS12315
uniprot id: A0A1D7TMK1
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

1193502:SHALO RS09980
gene id: 1193502:SHALO_RS09980
uniprot id: A0A1D7TL83
names: Similarity
messages: Belongs to the TrpF family.

1193502:SHALO RS08260
gene id: 1193502:SHALO_RS08260
uniprot id: A0A1D7TKH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1193502:SHALO RS15185
gene id: 1193502:SHALO_RS15185
uniprot id: A0A1D7THE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1193502:SHALO RS11355
gene id: 1193502:SHALO_RS11355
uniprot id: A0A1D7TM07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1193502:SHALO RS01585
gene id: 1193502:SHALO_RS01585
uniprot id: A0A1D7TGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1193502:SHALO RS08150
gene id: 1193502:SHALO_RS08150
uniprot id: A0A1D7TK67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

1193502:SHALO RS10660
gene id: 1193502:SHALO_RS10660
uniprot id: A0A1D7TLL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS03435
gene id: 1193502:SHALO_RS03435
uniprot id: A0A1D7THY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1193502:SHALO RS02335
gene id: 1193502:SHALO_RS02335
uniprot id: A0A1D7TGW5
names: Similarity
messages: Belongs to the leucine-binding protein family.

1193502:SHALO RS12540
gene id: 1193502:SHALO_RS12540
uniprot id: A0A1D7TMP6
names: Similarity
messages: Belongs to the PspA/IM30 family.

1193502:SHALO RS12020
gene id: 1193502:SHALO_RS12020
uniprot id: A0A1D7TML9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS09785
gene id: 1193502:SHALO_RS09785
uniprot id: A0A1D7TL40
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1193502:SHALO RS03065
gene id: 1193502:SHALO_RS03065
uniprot id: A0A1D7THE6
names: Similarity
messages: Belongs to the DEAD box helicase family.

1193502:SHALO RS07890
gene id: 1193502:SHALO_RS07890
uniprot id: A0A1D7TK71
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS06235
gene id: 1193502:SHALO_RS06235
uniprot id: A0A1D7TJG2
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

1193502:SHALO RS04165
gene id: 1193502:SHALO_RS04165
uniprot id: A0A1D7TI43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1193502:SHALO RS12660
gene id: 1193502:SHALO_RS12660
uniprot id: A0A1D7TMS7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1193502:SHALO RS12080
gene id: 1193502:SHALO_RS12080
uniprot id: A0A1D7TME0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS10395
gene id: 1193502:SHALO_RS10395
uniprot id: A0A1D7TLI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS03875
gene id: 1193502:SHALO_RS03875
uniprot id: A0A1D7TI64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1193502:SHALO RS01110
gene id: 1193502:SHALO_RS01110
uniprot id: A0A1D7TG86
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00040
gene id: 1193502:SHALO_RS00040
uniprot id: A0A1D7TFP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1193502:SHALO RS00570
gene id: 1193502:SHALO_RS00570
uniprot id: A0A1D7TFY9
names: Similarity
messages: Belongs to the type III secretion exporter family.

1193502:SHALO RS06075
gene id: 1193502:SHALO_RS06075
uniprot id: A0A1D7TIX8
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

1193502:SHALO RS12785
gene id: 1193502:SHALO_RS12785
uniprot id: A0A1D7TMT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

1193502:SHALO RS02125
gene id: 1193502:SHALO_RS02125
uniprot id: A0A1D7TH92
names: Subcellular Location Annotation
messages: Secreted

1193502:SHALO RS13195
gene id: 1193502:SHALO_RS13195
uniprot id: A0A1D7TN39
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1193502:SHALO RS11295
gene id: 1193502:SHALO_RS11295
uniprot id: A0A1D7TLY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1193502:SHALO RS08865
gene id: 1193502:SHALO_RS08865
uniprot id: A0A1D7TKU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1193502:SHALO RS01440
gene id: 1193502:SHALO_RS01440
uniprot id: A0A1D7TGF1
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1193502:SHALO RS06055
gene id: 1193502:SHALO_RS06055
uniprot id: A0A1D7TIX6
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

1193502:SHALO RS13215
gene id: 1193502:SHALO_RS13215
uniprot id: A0A1D7TN97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1193502:SHALO RS12025
gene id: 1193502:SHALO_RS12025
uniprot id: A0A1D7TMF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1193502:SHALO RS01280
gene id: 1193502:SHALO_RS01280
uniprot id: A0A1D7TGD3
names: Similarity
messages: Belongs to the GSP E family.

1193502:SHALO RS04440
gene id: 1193502:SHALO_RS04440
uniprot id: A0A1D7TIG9
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1193502:SHALO RS14185
gene id: 1193502:SHALO_RS14185
uniprot id: A0A1D7TNN8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00940
gene id: 1193502:SHALO_RS00940
uniprot id: A0A1D7TG36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS02090
gene id: 1193502:SHALO_RS02090
uniprot id: A0A1D7TGR2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1193502:SHALO RS10195
gene id: 1193502:SHALO_RS10195
uniprot id: A0A1D7TLG0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1193502:SHALO RS09850
gene id: 1193502:SHALO_RS09850
uniprot id: A0A1D7TL71
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06025
gene id: 1193502:SHALO_RS06025
uniprot id: A0A1D7TIW9
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.
messages: Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.

1193502:SHALO RS02915
gene id: 1193502:SHALO_RS02915
uniprot id: A0A1D7THB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1193502:SHALO RS11185
gene id: 1193502:SHALO_RS11185
uniprot id: A0A1D7TLZ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS12495
gene id: 1193502:SHALO_RS12495
uniprot id: A0A1D7TMM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1193502:SHALO RS13140
gene id: 1193502:SHALO_RS13140
uniprot id: A0A1D7TN05
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06695
gene id: 1193502:SHALO_RS06695
uniprot id: A0A1D7TJB1
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1193502:SHALO RS01990
gene id: 1193502:SHALO_RS01990
uniprot id: A0A1D7TGR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1193502:SHALO RS10830
gene id: 1193502:SHALO_RS10830
uniprot id: A0A1D7TLR7
names: Similarity
messages: Belongs to the NadC/ModD family.

1193502:SHALO RS01430
gene id: 1193502:SHALO_RS01430
uniprot id: A0A1D7TGG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1193502:SHALO RS05800
gene id: 1193502:SHALO_RS05800
uniprot id: A0A1D7TIW4
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06980
gene id: 1193502:SHALO_RS06980
uniprot id: A0A1D7TJG1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS02955
gene id: 1193502:SHALO_RS02955
uniprot id: A0A1D7THR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

1193502:SHALO RS01060
gene id: 1193502:SHALO_RS01060
uniprot id: A0A1D7TG79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1193502:SHALO RS07985
gene id: 1193502:SHALO_RS07985
uniprot id: A0A1D7TK29
names: Similarity
messages: Belongs to the TrpC family.

1193502:SHALO RS10530
gene id: 1193502:SHALO_RS10530
uniprot id: A0A1D7TLS3
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS11465
gene id: 1193502:SHALO_RS11465
uniprot id: A0A1D7TM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS11380
gene id: 1193502:SHALO_RS11380
uniprot id: A0A1D7TM46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1193502:SHALO RS02750
gene id: 1193502:SHALO_RS02750
uniprot id: A0A1D7TH30
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.

1193502:SHALO RS05910
gene id: 1193502:SHALO_RS05910
uniprot id: A0A1D7TIV7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1193502:SHALO RS02815
gene id: 1193502:SHALO_RS02815
uniprot id: A0A1D7TH45
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1193502:SHALO RS03375
gene id: 1193502:SHALO_RS03375
uniprot id: A0A1D7THD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1193502:SHALO RS02710
gene id: 1193502:SHALO_RS02710
uniprot id: A0A1D7THK9
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1193502:SHALO RS05535
gene id: 1193502:SHALO_RS05535
uniprot id: A0A1D7TIN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS12210
gene id: 1193502:SHALO_RS12210
uniprot id: A0A1D7TMH3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1193502:SHALO RS08470
gene id: 1193502:SHALO_RS08470
uniprot id: A0A1D7TKC8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1193502:SHALO RS07850
gene id: 1193502:SHALO_RS07850
uniprot id: A0A1D7TK04
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

1193502:SHALO RS01165
gene id: 1193502:SHALO_RS01165
uniprot id: A0A1D7TGA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1193502:SHALO RS07380
gene id: 1193502:SHALO_RS07380
uniprot id: A0A1D7TJQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1193502:SHALO RS02650
gene id: 1193502:SHALO_RS02650
uniprot id: A0A1D7TH19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

1193502:SHALO RS09995
gene id: 1193502:SHALO_RS09995
uniprot id: A0A1D7TLC1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1193502:SHALO RS10390
gene id: 1193502:SHALO_RS10390
uniprot id: A0A1D7TLK5
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS09655
gene id: 1193502:SHALO_RS09655
uniprot id: A0A1D7TL28
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1193502:SHALO RS14245
gene id: 1193502:SHALO_RS14245
uniprot id: A0A1D7TNP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1193502:SHALO RS14125
gene id: 1193502:SHALO_RS14125
uniprot id: A0A1D7TNJ3
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1193502:SHALO RS08450
gene id: 1193502:SHALO_RS08450
uniprot id: A0A1D7TKC4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1193502:SHALO RS01495
gene id: 1193502:SHALO_RS01495
uniprot id: A0A1D7TGF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1193502:SHALO RS00500
gene id: 1193502:SHALO_RS00500
uniprot id: A0A1D7TFW9
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

1193502:SHALO RS07305
gene id: 1193502:SHALO_RS07305
uniprot id: A0A1D7TJS0
names: Similarity
messages: Belongs to the acylphosphatase family.

1193502:SHALO RS07315
gene id: 1193502:SHALO_RS07315
uniprot id: A0A1D7TJN1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1193502:SHALO RS05915
gene id: 1193502:SHALO_RS05915
uniprot id: A0A1D7TJ40
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

1193502:SHALO RS05545
gene id: 1193502:SHALO_RS05545
uniprot id: A0A1D7TIW8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1193502:SHALO RS04575
gene id: 1193502:SHALO_RS04575
uniprot id: A0A1D7TI77
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS01905
gene id: 1193502:SHALO_RS01905
uniprot id: A0A1D7TGN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1193502:SHALO RS09780
gene id: 1193502:SHALO_RS09780
uniprot id: A0A1D7TL43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1193502:SHALO RS01810
gene id: 1193502:SHALO_RS01810
uniprot id: A0A1D7TH34
names: Subcellular Location Annotation
messages: Periplasm

1193502:SHALO RS02785
gene id: 1193502:SHALO_RS02785
uniprot id: A0A1D7TH53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1193502:SHALO RS01050
gene id: 1193502:SHALO_RS01050
uniprot id: A0A1D7TGK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1193502:SHALO RS02895
gene id: 1193502:SHALO_RS02895
uniprot id: A0A1D7TH88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1193502:SHALO RS00165
gene id: 1193502:SHALO_RS00165
uniprot id: A0A1D7TG35
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS12190
gene id: 1193502:SHALO_RS12190
uniprot id: A0A1D7TMG2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1193502:SHALO RS10505
gene id: 1193502:SHALO_RS10505
uniprot id: A0A1D7TLI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CitD family.
messages: Covalent carrier of the coenzyme of citrate lyase.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.

1193502:SHALO RS02410
gene id: 1193502:SHALO_RS02410
uniprot id: A0A1D7TGX9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1193502:SHALO RS00585
gene id: 1193502:SHALO_RS00585
uniprot id: A0A1D7TFX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1193502:SHALO RS11055
gene id: 1193502:SHALO_RS11055
uniprot id: A0A1D7TLU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1193502:SHALO RS12220
gene id: 1193502:SHALO_RS12220
uniprot id: A0A1D7TMQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1193502:SHALO RS15035
gene id: 1193502:SHALO_RS15035
uniprot id: A0A1D7TP18
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1193502:SHALO RS02600
gene id: 1193502:SHALO_RS02600
uniprot id: A0A1D7TH13
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS12695
gene id: 1193502:SHALO_RS12695
uniprot id: A0A1D7TMT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

1193502:SHALO RS11700
gene id: 1193502:SHALO_RS11700
uniprot id: A0A1D7TM67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Membrane

1193502:SHALO RS01720
gene id: 1193502:SHALO_RS01720
uniprot id: A0A1D7TGM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1193502:SHALO RS06480
gene id: 1193502:SHALO_RS06480
uniprot id: A0A1D7TJA4
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

1193502:SHALO RS01225
gene id: 1193502:SHALO_RS01225
uniprot id: A0A1D7TG87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1193502:SHALO RS03730
gene id: 1193502:SHALO_RS03730
uniprot id: A0A1D7TI35
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS07590
gene id: 1193502:SHALO_RS07590
uniprot id: A0A1D7TJU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1193502:SHALO RS14135
gene id: 1193502:SHALO_RS14135
uniprot id: A0A1D7TNJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

1193502:SHALO RS01655
gene id: 1193502:SHALO_RS01655
uniprot id: A0A1D7TGY1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

1193502:SHALO RS15175
gene id: 1193502:SHALO_RS15175
uniprot id: A0A1D7TP51
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

1193502:SHALO RS11475
gene id: 1193502:SHALO_RS11475
uniprot id: A0A1D7TM21
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1193502:SHALO RS08570
gene id: 1193502:SHALO_RS08570
uniprot id: A0A1D7TKE8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1193502:SHALO RS02035
gene id: 1193502:SHALO_RS02035
uniprot id: A0A1D7TGQ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS14905
gene id: 1193502:SHALO_RS14905
uniprot id: A0A1D7TP26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1193502:SHALO RS03315
gene id: 1193502:SHALO_RS03315
uniprot id: A0A1D7THL9
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS00220
gene id: 1193502:SHALO_RS00220
uniprot id: A0A1D7TFR7
names: Similarity
messages: Belongs to the MEMO1 family.

1193502:SHALO RS09370
gene id: 1193502:SHALO_RS09370
uniprot id: A0A1D7TKW4
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS05550
gene id: 1193502:SHALO_RS05550
uniprot id: A0A1D7TIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS00010
gene id: 1193502:SHALO_RS00010
uniprot id: A0A1D7TFN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1193502:SHALO RS04010
gene id: 1193502:SHALO_RS04010
uniprot id: A0A1D7THR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1193502:SHALO RS02345
gene id: 1193502:SHALO_RS02345
uniprot id: A0A1D7TGY3
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS09930
gene id: 1193502:SHALO_RS09930
uniprot id: A0A1D7TL73
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1193502:SHALO RS10205
gene id: 1193502:SHALO_RS10205
uniprot id: A0A1D7TLD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

1193502:SHALO RS08340
gene id: 1193502:SHALO_RS08340
uniprot id: A0A1D7TKF5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1193502:SHALO RS13845
gene id: 1193502:SHALO_RS13845
uniprot id: A0A1D7TNF1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1193502:SHALO RS10605
gene id: 1193502:SHALO_RS10605
uniprot id: A0A1D7TLJ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS05480
gene id: 1193502:SHALO_RS05480
uniprot id: A0A1D7TIQ1
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1193502:SHALO RS12775
gene id: 1193502:SHALO_RS12775
uniprot id: A0A1D7TMT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1193502:SHALO RS11360
gene id: 1193502:SHALO_RS11360
uniprot id: A0A1D7TM06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1193502:SHALO RS03180
gene id: 1193502:SHALO_RS03180
uniprot id: A0A1D7THA9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1193502:SHALO RS12595
gene id: 1193502:SHALO_RS12595
uniprot id: A0A1D7TMP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS04005
gene id: 1193502:SHALO_RS04005
uniprot id: A0A1D7THV8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS01310
gene id: 1193502:SHALO_RS01310
uniprot id: A0A1D7TGC6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1193502:SHALO RS04305
gene id: 1193502:SHALO_RS04305
uniprot id: A0A1D7TI22
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1193502:SHALO RS05570
gene id: 1193502:SHALO_RS05570
uniprot id: A0A1D7TIN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS09550
gene id: 1193502:SHALO_RS09550
uniprot id: A0A1D7TL06
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1193502:SHALO RS03410
gene id: 1193502:SHALO_RS03410
uniprot id: A0A1D7THH7
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

1193502:SHALO RS09010
gene id: 1193502:SHALO_RS09010
uniprot id: A0A1D7TKP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1193502:SHALO RS08945
gene id: 1193502:SHALO_RS08945
uniprot id: A0A1D7TKR9
names: Similarity
messages: Belongs to the peptidase C40 family.

1193502:SHALO RS07145
gene id: 1193502:SHALO_RS07145
uniprot id: A0A1D7TJJ9
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1193502:SHALO RS02645
gene id: 1193502:SHALO_RS02645
uniprot id: A0A1D7TH39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

1193502:SHALO RS01635
gene id: 1193502:SHALO_RS01635
uniprot id: A0A1D7TGR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1193502:SHALO RS11570
gene id: 1193502:SHALO_RS11570
uniprot id: A0A1D7TM53
names: Similarity
messages: Belongs to the DEAD box helicase family.

1193502:SHALO RS00560
gene id: 1193502:SHALO_RS00560
uniprot id: A0A1D7TFZ3
names: Function
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

1193502:SHALO RS06300
gene id: 1193502:SHALO_RS06300
uniprot id: A0A1D7TJ59
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1193502:SHALO RS14515
gene id: 1193502:SHALO_RS14515
uniprot id: A0A1D7TNZ0
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

1193502:SHALO RS00695
gene id: 1193502:SHALO_RS00695
uniprot id: A0A1D7TFZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS09155
gene id: 1193502:SHALO_RS09155
uniprot id: A0A1D7TKS4
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS07155
gene id: 1193502:SHALO_RS07155
uniprot id: A0A1D7TJM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1193502:SHALO RS14635
gene id: 1193502:SHALO_RS14635
uniprot id: A0A1D7TNT8
names: Similarity
messages: Belongs to the asparagine synthetase family.

1193502:SHALO RS03155
gene id: 1193502:SHALO_RS03155
uniprot id: A0A1D7THF4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1193502:SHALO RS02725
gene id: 1193502:SHALO_RS02725
uniprot id: A0A1D7TH66
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS02605
gene id: 1193502:SHALO_RS02605
uniprot id: A0A1D7TH48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS12215
gene id: 1193502:SHALO_RS12215
uniprot id: A0A1D7TMI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1193502:SHALO RS14830
gene id: 1193502:SHALO_RS14830
uniprot id: A0A1D7TNY3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1193502:SHALO RS15120
gene id: 1193502:SHALO_RS15120
uniprot id: A0A1D7TP23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1193502:SHALO RS11545
gene id: 1193502:SHALO_RS11545
uniprot id: A0A1D7TM45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1193502:SHALO RS12310
gene id: 1193502:SHALO_RS12310
uniprot id: A0A1D7TMJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1193502:SHALO RS11425
gene id: 1193502:SHALO_RS11425
uniprot id: A0A1D7TM13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1193502:SHALO RS02415
gene id: 1193502:SHALO_RS02415
uniprot id: A0A1D7TH18
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1193502:SHALO RS03390
gene id: 1193502:SHALO_RS03390
uniprot id: A0A1D7THE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1193502:SHALO RS02810
gene id: 1193502:SHALO_RS02810
uniprot id: A0A1D7THN0
names: Similarity
messages: Belongs to the MlaA family.

1193502:SHALO RS09855
gene id: 1193502:SHALO_RS09855
uniprot id: A0A1D7TL69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1193502:SHALO RS06645
gene id: 1193502:SHALO_RS06645
uniprot id: A0A1D7TJE1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1193502:SHALO RS10215
gene id: 1193502:SHALO_RS10215
uniprot id: A0A1D7TLK3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1193502:SHALO RS06975
gene id: 1193502:SHALO_RS06975
uniprot id: A0A1D7TJI8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00625
gene id: 1193502:SHALO_RS00625
uniprot id: A0A1D7TG62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1193502:SHALO RS13420
gene id: 1193502:SHALO_RS13420
uniprot id: A0A1D7TND7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1193502:SHALO RS13840
gene id: 1193502:SHALO_RS13840
uniprot id: A0A1D7TNE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1193502:SHALO RS05645
gene id: 1193502:SHALO_RS05645
uniprot id: A0A1D7TIZ0
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1193502:SHALO RS12105
gene id: 1193502:SHALO_RS12105
uniprot id: A0A1D7TMF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1193502:SHALO RS05725
gene id: 1193502:SHALO_RS05725
uniprot id: A0A1D7TIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1193502:SHALO RS00505
gene id: 1193502:SHALO_RS00505
uniprot id: A0A1D7TFX8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1193502:SHALO RS06140
gene id: 1193502:SHALO_RS06140
uniprot id: A0A1D7TJ00
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1193502:SHALO RS14550
gene id: 1193502:SHALO_RS14550
uniprot id: A0A1D7TNS7
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1193502:SHALO RS09585
gene id: 1193502:SHALO_RS09585
uniprot id: A0A1D7TL01
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS12235
gene id: 1193502:SHALO_RS12235
uniprot id: A0A1D7TMI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1193502:SHALO RS12275
gene id: 1193502:SHALO_RS12275
uniprot id: A0A1D7TMJ0
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS11210
gene id: 1193502:SHALO_RS11210
uniprot id: A0A1D7TLY0
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1193502:SHALO RS12680
gene id: 1193502:SHALO_RS12680
uniprot id: A0A1D7TMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1193502:SHALO RS04335
gene id: 1193502:SHALO_RS04335
uniprot id: A0A1D7TI38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1193502:SHALO RS14340
gene id: 1193502:SHALO_RS14340
uniprot id: A0A1D7TNR8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1193502:SHALO RS02135
gene id: 1193502:SHALO_RS02135
uniprot id: A0A1D7TGV2
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06955
gene id: 1193502:SHALO_RS06955
uniprot id: A0A1D7TJI1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS05805
gene id: 1193502:SHALO_RS05805
uniprot id: A0A1D7TIS9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1193502:SHALO RS03440
gene id: 1193502:SHALO_RS03440
uniprot id: A0A1D7THG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1193502:SHALO RS11490
gene id: 1193502:SHALO_RS11490
uniprot id: A0A1D7TM62
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1193502:SHALO RS02885
gene id: 1193502:SHALO_RS02885
uniprot id: A0A1D7TH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1193502:SHALO RS07120
gene id: 1193502:SHALO_RS07120
uniprot id: A0A1D7TJT3
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1193502:SHALO RS13670
gene id: 1193502:SHALO_RS13670
uniprot id: A0A1D7TNC7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1193502:SHALO RS01230
gene id: 1193502:SHALO_RS01230
uniprot id: A0A1D7TGB8
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1193502:SHALO RS07275
gene id: 1193502:SHALO_RS07275
uniprot id: A0A1D7TJW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1193502:SHALO RS00600
gene id: 1193502:SHALO_RS00600
uniprot id: A0A1D7TFZ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1193502:SHALO RS12935
gene id: 1193502:SHALO_RS12935
uniprot id: A0A1D7TMW1
names: Similarity
messages: Belongs to the UPF0251 family.

1193502:SHALO RS02580
gene id: 1193502:SHALO_RS02580
uniprot id: A0A1D7TGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS14710
gene id: 1193502:SHALO_RS14710
uniprot id: A0A1D7TNV6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1193502:SHALO RS09665
gene id: 1193502:SHALO_RS09665
uniprot id: A0A1D7TL97
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1193502:SHALO RS15045
gene id: 1193502:SHALO_RS15045
uniprot id: A0A1D7TP29
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1193502:SHALO RS00970
gene id: 1193502:SHALO_RS00970
uniprot id: A0A1D7TG37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS08455
gene id: 1193502:SHALO_RS08455
uniprot id: A0A1D7TKC9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1193502:SHALO RS08225
gene id: 1193502:SHALO_RS08225
uniprot id: A0A1D7TK84
names: Similarity
messages: Belongs to the class-I fumarase family.

1193502:SHALO RS12195
gene id: 1193502:SHALO_RS12195
uniprot id: A0A1D7TMF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1193502:SHALO RS15170
gene id: 1193502:SHALO_RS15170
uniprot id: A0A1D7TP33
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS07065
gene id: 1193502:SHALO_RS07065
uniprot id: A0A1D7TJI9
names: Similarity
messages: Belongs to the peptidase A31 family.

1193502:SHALO RS12300
gene id: 1193502:SHALO_RS12300
uniprot id: A0A1D7TMK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1193502:SHALO RS11780
gene id: 1193502:SHALO_RS11780
uniprot id: A0A1D7TM80
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1193502:SHALO RS08710
gene id: 1193502:SHALO_RS08710
uniprot id: A0A1D7TKQ8
names: Similarity
messages: Belongs to the aspartokinase family.

1193502:SHALO RS07060
gene id: 1193502:SHALO_RS07060
uniprot id: A0A1D7TJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

1193502:SHALO RS04000
gene id: 1193502:SHALO_RS04000
uniprot id: A0A1D7THX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1193502:SHALO RS15135
gene id: 1193502:SHALO_RS15135
uniprot id: A0A1D7TP36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1193502:SHALO RS13965
gene id: 1193502:SHALO_RS13965
uniprot id: A0A1D7TNI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1193502:SHALO RS00665
gene id: 1193502:SHALO_RS00665
uniprot id: A0A1D7TG11
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1193502:SHALO RS05050
gene id: 1193502:SHALO_RS05050
uniprot id: A0A1D7TII3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1193502:SHALO RS09480
gene id: 1193502:SHALO_RS09480
uniprot id: A0A1D7TKY9
names: Similarity
messages: Belongs to the P(II) protein family.

1193502:SHALO RS14870
gene id: 1193502:SHALO_RS14870
uniprot id: A0A1D7TNZ8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1193502:SHALO RS08125
gene id: 1193502:SHALO_RS08125
uniprot id: A0A1D7TK64
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

1193502:SHALO RS03445
gene id: 1193502:SHALO_RS03445
uniprot id: A0A1D7THM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1193502:SHALO RS10705
gene id: 1193502:SHALO_RS10705
uniprot id: A0A1D7TLP3
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS10090
gene id: 1193502:SHALO_RS10090
uniprot id: A0A1D7TLA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1193502:SHALO RS09110
gene id: 1193502:SHALO_RS09110
uniprot id: A0A1D7TKR0
names: Similarity
messages: Belongs to the peptidase C40 family.

1193502:SHALO RS04275
gene id: 1193502:SHALO_RS04275
uniprot id: A0A1D7TI08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1193502:SHALO RS10840
gene id: 1193502:SHALO_RS10840
uniprot id: A0A1D7TLP8
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1193502:SHALO RS12375
gene id: 1193502:SHALO_RS12375
uniprot id: A0A1D7TML3
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

1193502:SHALO RS11075
gene id: 1193502:SHALO_RS11075
uniprot id: A0A1D7TLU6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1193502:SHALO RS00815
gene id: 1193502:SHALO_RS00815
uniprot id: A0A1D7TG40
names: Similarity
messages: Belongs to the P(II) protein family.

1193502:SHALO RS13175
gene id: 1193502:SHALO_RS13175
uniprot id: A0A1D7TN12
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS05250
gene id: 1193502:SHALO_RS05250
uniprot id: A0A1D7TIJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

1193502:SHALO RS08160
gene id: 1193502:SHALO_RS08160
uniprot id: A0A1D7TK69
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS10520
gene id: 1193502:SHALO_RS10520
uniprot id: A0A1D7TLK4
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS02965
gene id: 1193502:SHALO_RS02965
uniprot id: A0A1D7THC8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1193502:SHALO RS03490
gene id: 1193502:SHALO_RS03490
uniprot id: A0A1D7THH2
names: Similarity
messages: Belongs to the fabD family.

1193502:SHALO RS11315
gene id: 1193502:SHALO_RS11315
uniprot id: A0A1D7TLZ4
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1193502:SHALO RS03380
gene id: 1193502:SHALO_RS03380
uniprot id: A0A1D7THJ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1193502:SHALO RS00985
gene id: 1193502:SHALO_RS00985
uniprot id: A0A1D7TG68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1193502:SHALO RS00880
gene id: 1193502:SHALO_RS00880
uniprot id: A0A1D7TGA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS03420
gene id: 1193502:SHALO_RS03420
uniprot id: A0A1D7THJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1193502:SHALO RS02440
gene id: 1193502:SHALO_RS02440
uniprot id: A0A1D7TGZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1193502:SHALO RS07320
gene id: 1193502:SHALO_RS07320
uniprot id: A0A1D7TJN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1193502:SHALO RS12950
gene id: 1193502:SHALO_RS12950
uniprot id: A0A1D7TMX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1193502:SHALO RS03280
gene id: 1193502:SHALO_RS03280
uniprot id: A0A1D7THH5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1193502:SHALO RS08615
gene id: 1193502:SHALO_RS08615
uniprot id: A0A1D7TKN7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1193502:SHALO RS14800
gene id: 1193502:SHALO_RS14800
uniprot id: A0A1D7TNX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1193502:SHALO RS03470
gene id: 1193502:SHALO_RS03470
uniprot id: A0A1D7THJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1193502:SHALO RS00770
gene id: 1193502:SHALO_RS00770
uniprot id: A0A1D7TFZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1193502:SHALO RS10105
gene id: 1193502:SHALO_RS10105
uniprot id: A0A1D7TLB8
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1193502:SHALO RS10825
gene id: 1193502:SHALO_RS10825
uniprot id: A0A1D7TLS7
names: Similarity
messages: Belongs to the IMPACT family.

1193502:SHALO RS07230
gene id: 1193502:SHALO_RS07230
uniprot id: A0A1D7TJN7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1193502:SHALO RS06800
gene id: 1193502:SHALO_RS06800
uniprot id: A0A1D7TJC8
names: Similarity
messages: Belongs to the DNA photolyase family.

1193502:SHALO RS13370
gene id: 1193502:SHALO_RS13370
uniprot id: A0A1D7TNC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1193502:SHALO RS00590
gene id: 1193502:SHALO_RS00590
uniprot id: A0A1D7TFX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS03545
gene id: 1193502:SHALO_RS03545
uniprot id: A0A1D7THN9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1193502:SHALO RS07685
gene id: 1193502:SHALO_RS07685
uniprot id: A0A1D7TJX5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1193502:SHALO RS10975
gene id: 1193502:SHALO_RS10975
uniprot id: A0A1D7TLS6
names: Function
names: Similarity
messages: Belongs to the OMP decarboxylase family.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

1193502:SHALO RS03830
gene id: 1193502:SHALO_RS03830
uniprot id: A0A1D7TI59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1193502:SHALO RS09135
gene id: 1193502:SHALO_RS09135
uniprot id: A0A1D7TKR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1193502:SHALO RS13455
gene id: 1193502:SHALO_RS13455
uniprot id: A0A1D7TN66
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1193502:SHALO RS07390
gene id: 1193502:SHALO_RS07390
uniprot id: A0A1D7TJR0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1193502:SHALO RS07670
gene id: 1193502:SHALO_RS07670
uniprot id: A0A1D7TJW6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1193502:SHALO RS04770
gene id: 1193502:SHALO_RS04770
uniprot id: A0A1D7TIG1
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1193502:SHALO RS09250
gene id: 1193502:SHALO_RS09250
uniprot id: A0A1D7TKU9
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS13835
gene id: 1193502:SHALO_RS13835
uniprot id: A0A1D7TNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS01140
gene id: 1193502:SHALO_RS01140
uniprot id: A0A1D7TG75
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1193502:SHALO RS03455
gene id: 1193502:SHALO_RS03455
uniprot id: A0A1D7THF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1193502:SHALO RS13230
gene id: 1193502:SHALO_RS13230
uniprot id: A0A1D7TN25
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

1193502:SHALO RS05345
gene id: 1193502:SHALO_RS05345
uniprot id: A0A1D7TIS5
names: Similarity
messages: Belongs to the hemerythrin family.

1193502:SHALO RS08780
gene id: 1193502:SHALO_RS08780
uniprot id: A0A1D7TKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1193502:SHALO RS11060
gene id: 1193502:SHALO_RS11060
uniprot id: A0A1D7TLV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1193502:SHALO RS12145
gene id: 1193502:SHALO_RS12145
uniprot id: A0A1D7TME8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1193502:SHALO RS10125
gene id: 1193502:SHALO_RS10125
uniprot id: A0A1D7TLC6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1193502:SHALO RS02870
gene id: 1193502:SHALO_RS02870
uniprot id: A0A1D7THB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1193502:SHALO RS06515
gene id: 1193502:SHALO_RS06515
uniprot id: A0A1D7TJG7
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1193502:SHALO RS13815
gene id: 1193502:SHALO_RS13815
uniprot id: A0A1D7TND5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1193502:SHALO RS05520
gene id: 1193502:SHALO_RS05520
uniprot id: A0A1D7TIM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1193502:SHALO RS13505
gene id: 1193502:SHALO_RS13505
uniprot id: A0A1D7TN72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1193502:SHALO RS13800
gene id: 1193502:SHALO_RS13800
uniprot id: A0A1D7TNC9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1193502:SHALO RS12035
gene id: 1193502:SHALO_RS12035
uniprot id: A0A1D7TME9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1193502:SHALO RS03690
gene id: 1193502:SHALO_RS03690
uniprot id: A0A1D7THR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS00055
gene id: 1193502:SHALO_RS00055
uniprot id: A0A1D7TG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1193502:SHALO RS01465
gene id: 1193502:SHALO_RS01465
uniprot id: A0A1D7TGG7
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1193502:SHALO RS04050
gene id: 1193502:SHALO_RS04050
uniprot id: A0A1D7THY3
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1193502:SHALO RS00990
gene id: 1193502:SHALO_RS00990
uniprot id: A0A1D7TG46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS05640
gene id: 1193502:SHALO_RS05640
uniprot id: A0A1D7TIQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1193502:SHALO RS00645
gene id: 1193502:SHALO_RS00645
uniprot id: A0A1D7TFY8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1193502:SHALO RS01270
gene id: 1193502:SHALO_RS01270
uniprot id: A0A1D7TGC7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1193502:SHALO RS02360
gene id: 1193502:SHALO_RS02360
uniprot id: A0A1D7TH33
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

1193502:SHALO RS01305
gene id: 1193502:SHALO_RS01305
uniprot id: A0A1D7TGQ9
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1193502:SHALO RS12800
gene id: 1193502:SHALO_RS12800
uniprot id: A0A1D7TMU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS12365
gene id: 1193502:SHALO_RS12365
uniprot id: A0A1D7TML2
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1193502:SHALO RS14070
gene id: 1193502:SHALO_RS14070
uniprot id: A0A1D7TNH7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1193502:SHALO RS11070
gene id: 1193502:SHALO_RS11070
uniprot id: A0A1D7TLU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1193502:SHALO RS12135
gene id: 1193502:SHALO_RS12135
uniprot id: A0A1D7TMH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1193502:SHALO RS04620
gene id: 1193502:SHALO_RS04620
uniprot id: A0A1D7TIC8
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06760
gene id: 1193502:SHALO_RS06760
uniprot id: A0A1D7TJB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS00930
gene id: 1193502:SHALO_RS00930
uniprot id: A0A1D7TGC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1193502:SHALO RS08025
gene id: 1193502:SHALO_RS08025
uniprot id: A0A1D7TK44
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

1193502:SHALO RS00535
gene id: 1193502:SHALO_RS00535
uniprot id: A0A1D7TFV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1193502:SHALO RS05370
gene id: 1193502:SHALO_RS05370
uniprot id: A0A1D7TIK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS07080
gene id: 1193502:SHALO_RS07080
uniprot id: A0A1D7TJI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1193502:SHALO RS01485
gene id: 1193502:SHALO_RS01485
uniprot id: A0A1D7TGM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1193502:SHALO RS04235
gene id: 1193502:SHALO_RS04235
uniprot id: A0A1D7TI17
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS00910
gene id: 1193502:SHALO_RS00910
uniprot id: A0A1D7TG52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1193502:SHALO RS14955
gene id: 1193502:SHALO_RS14955
uniprot id: A0A1D7TP37
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1193502:SHALO RS02425
gene id: 1193502:SHALO_RS02425
uniprot id: A0A1D7TGW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1193502:SHALO RS14810
gene id: 1193502:SHALO_RS14810
uniprot id: A0A1D7TNX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1193502:SHALO RS01975
gene id: 1193502:SHALO_RS01975
uniprot id: A0A1D7TGS1
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS10710
gene id: 1193502:SHALO_RS10710
uniprot id: A0A1D7TLL6
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS09070
gene id: 1193502:SHALO_RS09070
uniprot id: A0A1D7TKQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Membrane

1193502:SHALO RS11375
gene id: 1193502:SHALO_RS11375
uniprot id: A0A1D7TM10
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS07010
gene id: 1193502:SHALO_RS07010
uniprot id: A0A1D7TJH4
names: Similarity
messages: Belongs to the UPF0045 family.

1193502:SHALO RS08905
gene id: 1193502:SHALO_RS08905
uniprot id: A0A1D7TKM0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1193502:SHALO RS03840
gene id: 1193502:SHALO_RS03840
uniprot id: A0A1D7THT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1193502:SHALO RS01145
gene id: 1193502:SHALO_RS01145
uniprot id: A0A1D7TG90
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1193502:SHALO RS10330
gene id: 1193502:SHALO_RS10330
uniprot id: A0A1D7TLE9
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

1193502:SHALO RS01675
gene id: 1193502:SHALO_RS01675
uniprot id: A0A1D7TGI4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1193502:SHALO RS15090
gene id: 1193502:SHALO_RS15090
uniprot id: A0A1D7TP48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS01370
gene id: 1193502:SHALO_RS01370
uniprot id: A0A1D7TGE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1193502:SHALO RS06700
gene id: 1193502:SHALO_RS06700
uniprot id: A0A1D7TJE9
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS01360
gene id: 1193502:SHALO_RS01360
uniprot id: A0A1D7TGD6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1193502:SHALO RS00605
gene id: 1193502:SHALO_RS00605
uniprot id: A0A1D7TFZ6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1193502:SHALO RS10160
gene id: 1193502:SHALO_RS10160
uniprot id: A0A1D7TLD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS00175
gene id: 1193502:SHALO_RS00175
uniprot id: A0A1D7TFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

1193502:SHALO RS08130
gene id: 1193502:SHALO_RS08130
uniprot id: A0A1D7TK66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS12770
gene id: 1193502:SHALO_RS12770
uniprot id: A0A1D7TMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1193502:SHALO RS05670
gene id: 1193502:SHALO_RS05670
uniprot id: A0A1D7TIQ9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS06850
gene id: 1193502:SHALO_RS06850
uniprot id: A0A1D7TJH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

1193502:SHALO RS10895
gene id: 1193502:SHALO_RS10895
uniprot id: A0A1D7TM03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).

1193502:SHALO RS10055
gene id: 1193502:SHALO_RS10055
uniprot id: A0A1D7TLB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1193502:SHALO RS00635
gene id: 1193502:SHALO_RS00635
uniprot id: A0A1D7TG02
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS01515
gene id: 1193502:SHALO_RS01515
uniprot id: A0A1D7TGH7
names: Subcellular Location Annotation
messages: Cytoplasm

1193502:SHALO RS08490
gene id: 1193502:SHALO_RS08490
uniprot id: A0A1D7TKC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1193502:SHALO RS09260
gene id: 1193502:SHALO_RS09260
uniprot id: A0A1D7TKU2
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS04105
gene id: 1193502:SHALO_RS04105
uniprot id: A0A1D7THU0
names: Similarity
messages: Belongs to the CvfB family.

1193502:SHALO RS02900
gene id: 1193502:SHALO_RS02900
uniprot id: A0A1D7TH60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS02045
gene id: 1193502:SHALO_RS02045
uniprot id: A0A1D7TGY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS10955
gene id: 1193502:SHALO_RS10955
uniprot id: A0A1D7TLR8
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS05035
gene id: 1193502:SHALO_RS05035
uniprot id: A0A1D7TIH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1193502:SHALO RS13050
gene id: 1193502:SHALO_RS13050
uniprot id: A0A1D7TMZ2
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1193502:SHALO RS00435
gene id: 1193502:SHALO_RS00435
uniprot id: A0A1D7TFT8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS06085
gene id: 1193502:SHALO_RS06085
uniprot id: A0A1D7TJD5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1193502:SHALO RS03115
gene id: 1193502:SHALO_RS03115
uniprot id: A0A1D7THA2
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS04840
gene id: 1193502:SHALO_RS04840
uniprot id: A0A1D7TIN7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1193502:SHALO RS03100
gene id: 1193502:SHALO_RS03100
uniprot id: A0A1D7THE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

1193502:SHALO RS11215
gene id: 1193502:SHALO_RS11215
uniprot id: A0A1D7TLX0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1193502:SHALO RS13235
gene id: 1193502:SHALO_RS13235
uniprot id: A0A1D7TN20
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1193502:SHALO RS04310
gene id: 1193502:SHALO_RS04310
uniprot id: A0A1D7THX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1193502:SHALO RS12115
gene id: 1193502:SHALO_RS12115
uniprot id: A0A1D7TMF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1193502:SHALO RS10785
gene id: 1193502:SHALO_RS10785
uniprot id: A0A1D7TLP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS11970
gene id: 1193502:SHALO_RS11970
uniprot id: A0A1D7TMK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

1193502:SHALO RS14750
gene id: 1193502:SHALO_RS14750
uniprot id: A0A1D7TNW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1193502:SHALO RS15105
gene id: 1193502:SHALO_RS15105
uniprot id: A0A1D7TP34
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS11040
gene id: 1193502:SHALO_RS11040
uniprot id: A0A1D7TLU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

1193502:SHALO RS11090
gene id: 1193502:SHALO_RS11090
uniprot id: A0A1D7TLV9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1193502:SHALO RS07045
gene id: 1193502:SHALO_RS07045
uniprot id: A0A1D7TJI6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1193502:SHALO RS08635
gene id: 1193502:SHALO_RS08635
uniprot id: A0A1D7TKG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1193502:SHALO RS07340
gene id: 1193502:SHALO_RS07340
uniprot id: A0A1D7TJQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1193502:SHALO RS09775
gene id: 1193502:SHALO_RS09775
uniprot id: A0A1D7TL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1193502:SHALO RS03295
gene id: 1193502:SHALO_RS03295
uniprot id: A0A1D7THI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1193502:SHALO RS09675
gene id: 1193502:SHALO_RS09675
uniprot id: A0A1D7TL41
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1193502:SHALO RS03670
gene id: 1193502:SHALO_RS03670
uniprot id: A0A1D7THJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1193502:SHALO RS05635
gene id: 1193502:SHALO_RS05635
uniprot id: A0A1D7TIQ2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1193502:SHALO RS06915
gene id: 1193502:SHALO_RS06915
uniprot id: A0A1D7TJG3
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

1193502:SHALO RS11820
gene id: 1193502:SHALO_RS11820
uniprot id: A0A1D7TMH7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1193502:SHALO RS11615
gene id: 1193502:SHALO_RS11615
uniprot id: A0A1D7TME2
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1193502:SHALO RS04455
gene id: 1193502:SHALO_RS04455
uniprot id: A0A1D7TI49
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1193502:SHALO RS04465
gene id: 1193502:SHALO_RS04465
uniprot id: A0A1D7TI37
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1193502:SHALO RS09915
gene id: 1193502:SHALO_RS09915
uniprot id: A0A1D7TL65
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS13790
gene id: 1193502:SHALO_RS13790
uniprot id: A0A1D7TND1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1193502:SHALO RS09820
gene id: 1193502:SHALO_RS09820
uniprot id: A0A1D7TL67
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS13955
gene id: 1193502:SHALO_RS13955
uniprot id: A0A1D7TNK2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS12665
gene id: 1193502:SHALO_RS12665
uniprot id: A0A1D7TMY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fes family.
messages: Cytoplasm

1193502:SHALO RS13220
gene id: 1193502:SHALO_RS13220
uniprot id: A0A1D7TN35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1193502:SHALO RS01940
gene id: 1193502:SHALO_RS01940
uniprot id: A0A1D7TGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1193502:SHALO RS06960
gene id: 1193502:SHALO_RS06960
uniprot id: A0A1D7TJG5
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS10860
gene id: 1193502:SHALO_RS10860
uniprot id: A0A1D7TLP7
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1193502:SHALO RS00510
gene id: 1193502:SHALO_RS00510
uniprot id: A0A1D7TFY3
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1193502:SHALO RS07865
gene id: 1193502:SHALO_RS07865
uniprot id: A0A1D7TK31
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS00015
gene id: 1193502:SHALO_RS00015
uniprot id: A0A1D7TFP4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1193502:SHALO RS14425
gene id: 1193502:SHALO_RS14425
uniprot id: A0A1D7TNQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Cell membrane
messages: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1193502:SHALO RS06600
gene id: 1193502:SHALO_RS06600
uniprot id: A0A1D7TJC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

1193502:SHALO RS09615
gene id: 1193502:SHALO_RS09615
uniprot id: A0A1D7TL87
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1193502:SHALO RS11735
gene id: 1193502:SHALO_RS11735
uniprot id: A0A1D7TM87
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS08380
gene id: 1193502:SHALO_RS08380
uniprot id: A0A1D7TKB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS11155
gene id: 1193502:SHALO_RS11155
uniprot id: A0A1D7TLW9
names: Similarity
messages: Belongs to the acetaldehyde dehydrogenase family.

1193502:SHALO RS10985
gene id: 1193502:SHALO_RS10985
uniprot id: A0A1D7TLU5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1193502:SHALO RS01445
gene id: 1193502:SHALO_RS01445
uniprot id: A0A1D7TGE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1193502:SHALO RS07860
gene id: 1193502:SHALO_RS07860
uniprot id: A0A1D7TK06
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1193502:SHALO RS13915
gene id: 1193502:SHALO_RS13915
uniprot id: A0A1D7TNI1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1193502:SHALO RS14105
gene id: 1193502:SHALO_RS14105
uniprot id: A0A1D7TNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

1193502:SHALO RS09895
gene id: 1193502:SHALO_RS09895
uniprot id: A0A1D7TL81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Homopentamer. In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro.
messages: Mediates influx of magnesium ions.
messages: Membrane

1193502:SHALO RS07405
gene id: 1193502:SHALO_RS07405
uniprot id: A0A1D7TJU5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1193502:SHALO RS12185
gene id: 1193502:SHALO_RS12185
uniprot id: A0A1D7TMH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1193502:SHALO RS03860
gene id: 1193502:SHALO_RS03860
uniprot id: A0A1D7THS2
names: Similarity
messages: Belongs to the GARS family.

1193502:SHALO RS02470
gene id: 1193502:SHALO_RS02470
uniprot id: A0A1D7TH02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1193502:SHALO RS05245
gene id: 1193502:SHALO_RS05245
uniprot id: A0A1D7TIP5
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS08985
gene id: 1193502:SHALO_RS08985
uniprot id: A0A1D7TKN4
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1193502:SHALO RS02595
gene id: 1193502:SHALO_RS02595
uniprot id: A0A1D7TH27
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1193502:SHALO RS08680
gene id: 1193502:SHALO_RS08680
uniprot id: A0A1D7TKG9
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1193502:SHALO RS14140
gene id: 1193502:SHALO_RS14140
uniprot id: A0A1D7TNM1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1193502:SHALO RS01400
gene id: 1193502:SHALO_RS01400
uniprot id: A0A1D7TGF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1193502:SHALO RS01175
gene id: 1193502:SHALO_RS01175
uniprot id: A0A1D7TGB1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1193502:SHALO RS09520
gene id: 1193502:SHALO_RS09520
uniprot id: A0A1D7TKZ0
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

1193502:SHALO RS01945
gene id: 1193502:SHALO_RS01945
uniprot id: A0A1D7TGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1193502:SHALO RS01695
gene id: 1193502:SHALO_RS01695
uniprot id: A0A1D7TGK5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1193502:SHALO RS11760
gene id: 1193502:SHALO_RS11760
uniprot id: A0A1D7TM86
names: Similarity
messages: Belongs to the PhoH family.

1193502:SHALO RS10290
gene id: 1193502:SHALO_RS10290
uniprot id: A0A1D7TLE3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1193502:SHALO RS12200
gene id: 1193502:SHALO_RS12200
uniprot id: A0A1D7TMI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1193502:SHALO RS03510
gene id: 1193502:SHALO_RS03510
uniprot id: A0A1D7THK1
names: Similarity
messages: Belongs to the glutamate synthase family.

1193502:SHALO RS14795
gene id: 1193502:SHALO_RS14795
uniprot id: A0A1D7TNW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

1193502:SHALO RS01555
gene id: 1193502:SHALO_RS01555
uniprot id: A0A1D7TGW0
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1193502:SHALO RS06020
gene id: 1193502:SHALO_RS06020
uniprot id: A0A1D7TJ05
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

1193502:SHALO RS12295
gene id: 1193502:SHALO_RS12295
uniprot id: A0A1D7TMH5
names: Similarity
messages: Belongs to the FeoA family.

1193502:SHALO RS03360
gene id: 1193502:SHALO_RS03360
uniprot id: A0A1D7THG7
names: Similarity
messages: Belongs to the peptidase S41A family.

1193502:SHALO RS03480
gene id: 1193502:SHALO_RS03480
uniprot id: A0A1D7THL3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1193502:SHALO RS03865
gene id: 1193502:SHALO_RS03865
uniprot id: A0A1D7THN7
names: Subcellular Location Annotation
messages: Membrane

1193502:SHALO RS06785
gene id: 1193502:SHALO_RS06785
uniprot id: A0A1D7TJG6
names: Similarity
messages: Belongs to the nitroreductase family.

1193502:SHALO RS13210
gene id: 1193502:SHALO_RS13210
uniprot id: A0A1D7TN36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

1193502:SHALO RS07105
gene id: 1193502:SHALO_RS07105
uniprot id: A0A1D7TJL9
names: Similarity
messages: Belongs to the HupF/HypC family.

1193502:SHALO RS12675
gene id: 1193502:SHALO_RS12675
uniprot id: A0A1D7TMR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1193502:SHALO RS09500
gene id: 1193502:SHALO_RS09500
uniprot id: A0A1D7TKZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1193502:SHALO RS09960
gene id: 1193502:SHALO_RS09960
uniprot id: A0A1D7TLF8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1193502:SHALO RS14715
gene id: 1193502:SHALO_RS14715
uniprot id: A0A1D7TNY2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1193502:SHALO RS11940
gene id: 1193502:SHALO_RS11940
uniprot id: A0A1D7TMC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1193502:SHALO RS01575
gene id: 1193502:SHALO_RS01575
uniprot id: A0A1D7TGG4
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.