115561:HHSLTHF2 RS14180
gene id: 115561:HHSLTHF2_RS14180
uniprot id: A0A6F8U723
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MerT family.
messages: Cell inner membrane
messages: Membrane

115561:HHSLTHF2 RS12340
gene id: 115561:HHSLTHF2_RS12340
uniprot id: A0A6F8U5X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

115561:HHSLTHF2 RS08795
gene id: 115561:HHSLTHF2_RS08795
uniprot id: A0A291JX30
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

115561:HHSLTHF2 RS02705
gene id: 115561:HHSLTHF2_RS02705
uniprot id: A0A6F8TZ16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

115561:HHSLTHF2 RS01920
gene id: 115561:HHSLTHF2_RS01920
uniprot id: A0A6F8U025
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

115561:HHSLTHF2 RS10965
gene id: 115561:HHSLTHF2_RS10965
uniprot id: A0A291JY40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

115561:HHSLTHF2 RS11565
gene id: 115561:HHSLTHF2_RS11565
uniprot id: A0A6F8U639
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

115561:HHSLTHF2 RS01005
gene id: 115561:HHSLTHF2_RS01005
uniprot id: A0A6F8TZC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

115561:HHSLTHF2 RS03255
gene id: 115561:HHSLTHF2_RS03255
uniprot id: A0A6F8U1G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

115561:HHSLTHF2 RS17985
gene id: 115561:HHSLTHF2_RS17985
uniprot id: A0A291JPU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

115561:HHSLTHF2 RS12815
gene id: 115561:HHSLTHF2_RS12815
uniprot id: A0A6F8U510
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

115561:HHSLTHF2 RS15765
gene id: 115561:HHSLTHF2_RS15765
uniprot id: A0A6F8U6E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

115561:HHSLTHF2 RS08740
gene id: 115561:HHSLTHF2_RS08740
uniprot id: A0A291JX23
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

115561:HHSLTHF2 RS04125
gene id: 115561:HHSLTHF2_RS04125
uniprot id: A0A6F8U201
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

115561:HHSLTHF2 RS02355
gene id: 115561:HHSLTHF2_RS02355
uniprot id: A0A6F8TYV0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

115561:HHSLTHF2 RS08735
gene id: 115561:HHSLTHF2_RS08735
uniprot id: A0A6F8U2E3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

115561:HHSLTHF2 RS00925
gene id: 115561:HHSLTHF2_RS00925
uniprot id: A0A291JRN7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

115561:HHSLTHF2 RS01000
gene id: 115561:HHSLTHF2_RS01000
uniprot id: A0A6F8U032
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

115561:HHSLTHF2 RS10880
gene id: 115561:HHSLTHF2_RS10880
uniprot id: A0A6F8U5S4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

115561:HHSLTHF2 RS00390
gene id: 115561:HHSLTHF2_RS00390
uniprot id: A0A6F8TZR0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

115561:HHSLTHF2 RS17900
gene id: 115561:HHSLTHF2_RS17900
uniprot id: A0A291JSQ1
names: Similarity
messages: Belongs to the P(II) protein family.

115561:HHSLTHF2 RS00245
gene id: 115561:HHSLTHF2_RS00245
uniprot id: A0A6F8TXP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

115561:HHSLTHF2 RS11315
gene id: 115561:HHSLTHF2_RS11315
uniprot id: A0A6F8U5Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

115561:HHSLTHF2 RS00930
gene id: 115561:HHSLTHF2_RS00930
uniprot id: A0A6F8U0A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

115561:HHSLTHF2 RS06925
gene id: 115561:HHSLTHF2_RS06925
uniprot id: A0A6F8U3Q9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

115561:HHSLTHF2 RS18575
gene id: 115561:HHSLTHF2_RS18575
uniprot id: A0A6F8UAH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

115561:HHSLTHF2 RS17970
gene id: 115561:HHSLTHF2_RS17970
uniprot id: A0A291JPT8
names: Subcellular Location Annotation
messages: Membrane

115561:HHSLTHF2 RS00700
gene id: 115561:HHSLTHF2_RS00700
uniprot id: A0A6F8U048
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

115561:HHSLTHF2 RS00955
gene id: 115561:HHSLTHF2_RS00955
uniprot id: A0A291JRV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

115561:HHSLTHF2 RS18835
gene id: 115561:HHSLTHF2_RS18835
uniprot id: A0A291JS34
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

115561:HHSLTHF2 RS12800
gene id: 115561:HHSLTHF2_RS12800
uniprot id: A0A6F8U6V9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

115561:HHSLTHF2 RS08090
gene id: 115561:HHSLTHF2_RS08090
uniprot id: A0A6F8U224
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

115561:HHSLTHF2 RS01800
gene id: 115561:HHSLTHF2_RS01800
uniprot id: A0A6F8U0N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

115561:HHSLTHF2 RS01665
gene id: 115561:HHSLTHF2_RS01665
uniprot id: A0A6F8U0N8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

115561:HHSLTHF2 RS08085
gene id: 115561:HHSLTHF2_RS08085
uniprot id: A0A6F8U3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

115561:HHSLTHF2 RS00850
gene id: 115561:HHSLTHF2_RS00850
uniprot id: A0A6F8TYL2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

115561:HHSLTHF2 RS01825
gene id: 115561:HHSLTHF2_RS01825
uniprot id: A0A6F8U0R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

115561:HHSLTHF2 RS12335
gene id: 115561:HHSLTHF2_RS12335
uniprot id: A0A6F8U6J6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

115561:HHSLTHF2 RS07130
gene id: 115561:HHSLTHF2_RS07130
uniprot id: A0A6F8U2X4
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

115561:HHSLTHF2 RS14210
gene id: 115561:HHSLTHF2_RS14210
uniprot id: A0A6F8U7P6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

115561:HHSLTHF2 RS00865
gene id: 115561:HHSLTHF2_RS00865
uniprot id: A0A6F8U078
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

115561:HHSLTHF2 RS04050
gene id: 115561:HHSLTHF2_RS04050
uniprot id: A0A6F8U1W2
names: Similarity
messages: Belongs to the YciI family.

115561:HHSLTHF2 RS08420
gene id: 115561:HHSLTHF2_RS08420
uniprot id: A0A6F8U3N9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

115561:HHSLTHF2 RS00960
gene id: 115561:HHSLTHF2_RS00960
uniprot id: A0A291JRV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

115561:HHSLTHF2 RS02375
gene id: 115561:HHSLTHF2_RS02375
uniprot id: A0A6F8U076
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

115561:HHSLTHF2 RS18680
gene id: 115561:HHSLTHF2_RS18680
uniprot id: A0A6F8UA70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

115561:HHSLTHF2 RS18685
gene id: 115561:HHSLTHF2_RS18685
uniprot id: A0A6F8U9K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

115561:HHSLTHF2 RS10985
gene id: 115561:HHSLTHF2_RS10985
uniprot id: A0A291JY81
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

115561:HHSLTHF2 RS15750
gene id: 115561:HHSLTHF2_RS15750
uniprot id: A0A291JR49
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

115561:HHSLTHF2 RS00965
gene id: 115561:HHSLTHF2_RS00965
uniprot id: A0A6F8TZI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

115561:HHSLTHF2 RS02630
gene id: 115561:HHSLTHF2_RS02630
uniprot id: A0A291JTY1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

115561:HHSLTHF2 RS18750
gene id: 115561:HHSLTHF2_RS18750
uniprot id: A0A6F8U9M0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

115561:HHSLTHF2 RS00910
gene id: 115561:HHSLTHF2_RS00910
uniprot id: A0A6F8U090
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

115561:HHSLTHF2 RS15625
gene id: 115561:HHSLTHF2_RS15625
uniprot id: A0A6F8U6P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

115561:HHSLTHF2 RS07355
gene id: 115561:HHSLTHF2_RS07355
uniprot id: A0A6F8U1M4
names: Similarity
messages: Belongs to the YoeB family.

115561:HHSLTHF2 RS09365
gene id: 115561:HHSLTHF2_RS09365
uniprot id: A0A6F8U441
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

115561:HHSLTHF2 RS02515
gene id: 115561:HHSLTHF2_RS02515
uniprot id: A0A6F8U178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

115561:HHSLTHF2 RS11505
gene id: 115561:HHSLTHF2_RS11505
uniprot id: A0A6F8U492
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

115561:HHSLTHF2 RS13730
gene id: 115561:HHSLTHF2_RS13730
uniprot id: A0A6F8U7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

115561:HHSLTHF2 RS05260
gene id: 115561:HHSLTHF2_RS05260
uniprot id: A0A6F8U2N2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

115561:HHSLTHF2 RS06655
gene id: 115561:HHSLTHF2_RS06655
uniprot id: A0A6F8U3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

115561:HHSLTHF2 RS18330
gene id: 115561:HHSLTHF2_RS18330
uniprot id: A0A6F8U7W4
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

115561:HHSLTHF2 RS06405
gene id: 115561:HHSLTHF2_RS06405
uniprot id: A0A6F8U1E2
names: Similarity
messages: Belongs to the UPF0260 family.

115561:HHSLTHF2 RS15260
gene id: 115561:HHSLTHF2_RS15260
uniprot id: A0A6F8U7J9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

115561:HHSLTHF2 RS00980
gene id: 115561:HHSLTHF2_RS00980
uniprot id: A0A6F8U0B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

115561:HHSLTHF2 RS00915
gene id: 115561:HHSLTHF2_RS00915
uniprot id: A0A6F8TZH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

115561:HHSLTHF2 RS01400
gene id: 115561:HHSLTHF2_RS01400
uniprot id: A0A6F8TZN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

115561:HHSLTHF2 RS13640
gene id: 115561:HHSLTHF2_RS13640
uniprot id: A0A291JPY2
names: Subcellular Location Annotation
messages: Cytoplasm

115561:HHSLTHF2 RS03885
gene id: 115561:HHSLTHF2_RS03885
uniprot id: A0A6F8U1T2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

115561:HHSLTHF2 RS05230
gene id: 115561:HHSLTHF2_RS05230
uniprot id: A0A6F8U2S9
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

115561:HHSLTHF2 RS14175
gene id: 115561:HHSLTHF2_RS14175
uniprot id: A0A6F8U7P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MerP family.
messages: Involved in mercury resistance. Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT.
messages: Monomer.
messages: Periplasm

115561:HHSLTHF2 RS09675
gene id: 115561:HHSLTHF2_RS09675
uniprot id: A0A6F8U3H5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

115561:HHSLTHF2 RS07030
gene id: 115561:HHSLTHF2_RS07030
uniprot id: A0A6F8U3J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

115561:HHSLTHF2 RS05445
gene id: 115561:HHSLTHF2_RS05445
uniprot id: A0A291JVG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

115561:HHSLTHF2 RS00985
gene id: 115561:HHSLTHF2_RS00985
uniprot id: A0A6F8U064
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

115561:HHSLTHF2 RS08755
gene id: 115561:HHSLTHF2_RS08755
uniprot id: A0A6F8U3U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

115561:HHSLTHF2 RS11400
gene id: 115561:HHSLTHF2_RS11400
uniprot id: A0A6F8U3W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

115561:HHSLTHF2 RS08385
gene id: 115561:HHSLTHF2_RS08385
uniprot id: A0A6F8U3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

115561:HHSLTHF2 RS07930
gene id: 115561:HHSLTHF2_RS07930
uniprot id: A0A291JSI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

115561:HHSLTHF2 RS13120
gene id: 115561:HHSLTHF2_RS13120
uniprot id: A0A6F8U701
names: Similarity
messages: Belongs to the YjdM family.

115561:HHSLTHF2 RS14185
gene id: 115561:HHSLTHF2_RS14185
uniprot id: A0A6F8U5I1
names: Function
messages: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

115561:HHSLTHF2 RS07845
gene id: 115561:HHSLTHF2_RS07845
uniprot id: A0A6F8U1X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

115561:HHSLTHF2 RS01030
gene id: 115561:HHSLTHF2_RS01030
uniprot id: A0A6F8TYD5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

115561:HHSLTHF2 RS03845
gene id: 115561:HHSLTHF2_RS03845
uniprot id: A0A6F8U1Q7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

115561:HHSLTHF2 RS00975
gene id: 115561:HHSLTHF2_RS00975
uniprot id: A0A6F8TYC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

115561:HHSLTHF2 RS10780
gene id: 115561:HHSLTHF2_RS10780
uniprot id: A0A6F8U5Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

115561:HHSLTHF2 RS01645
gene id: 115561:HHSLTHF2_RS01645
uniprot id: A0A6F8TZT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

115561:HHSLTHF2 RS02625
gene id: 115561:HHSLTHF2_RS02625
uniprot id: A0A6F8U0C9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

115561:HHSLTHF2 RS10895
gene id: 115561:HHSLTHF2_RS10895
uniprot id: A0A6F8U553
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

115561:HHSLTHF2 RS00880
gene id: 115561:HHSLTHF2_RS00880
uniprot id: A0A291JRQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

115561:HHSLTHF2 RS02420
gene id: 115561:HHSLTHF2_RS02420
uniprot id: A0A6F8U109
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

115561:HHSLTHF2 RS15485
gene id: 115561:HHSLTHF2_RS15485
uniprot id: A0A6F8U6T8
names: Similarity
messages: Belongs to the Dps family.

115561:HHSLTHF2 RS15375
gene id: 115561:HHSLTHF2_RS15375
uniprot id: A0A6F8U8M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

115561:HHSLTHF2 RS02700
gene id: 115561:HHSLTHF2_RS02700
uniprot id: A0A6F8U0H2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

115561:HHSLTHF2 RS09385
gene id: 115561:HHSLTHF2_RS09385
uniprot id: A0A6F8U325
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

115561:HHSLTHF2 RS08325
gene id: 115561:HHSLTHF2_RS08325
uniprot id: A0A6F8U3J1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

115561:HHSLTHF2 RS00995
gene id: 115561:HHSLTHF2_RS00995
uniprot id: A0A291JRN0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

115561:HHSLTHF2 RS18660
gene id: 115561:HHSLTHF2_RS18660
uniprot id: A0A6F8U9N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

115561:HHSLTHF2 RS17895
gene id: 115561:HHSLTHF2_RS17895
uniprot id: A0A6F8U7M2
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

115561:HHSLTHF2 RS00885
gene id: 115561:HHSLTHF2_RS00885
uniprot id: A0A6F8U092
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

115561:HHSLTHF2 RS08210
gene id: 115561:HHSLTHF2_RS08210
uniprot id: A0A6F8U3J9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

115561:HHSLTHF2 RS08075
gene id: 115561:HHSLTHF2_RS08075
uniprot id: A0A6F8U3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

115561:HHSLTHF2 RS00935
gene id: 115561:HHSLTHF2_RS00935
uniprot id: A0A6F8U054
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

115561:HHSLTHF2 RS15240
gene id: 115561:HHSLTHF2_RS15240
uniprot id: A0A6F8U878
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

115561:HHSLTHF2 RS03930
gene id: 115561:HHSLTHF2_RS03930
uniprot id: A0A6F8U217
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

115561:HHSLTHF2 RS12795
gene id: 115561:HHSLTHF2_RS12795
uniprot id: A0A6F8U636
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

115561:HHSLTHF2 RS01015
gene id: 115561:HHSLTHF2_RS01015
uniprot id: A0A6F8U0A9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

115561:HHSLTHF2 RS01025
gene id: 115561:HHSLTHF2_RS01025
uniprot id: A0A6F8TY42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

115561:HHSLTHF2 RS03795
gene id: 115561:HHSLTHF2_RS03795
uniprot id: A0A6F8U1P8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

115561:HHSLTHF2 RS12810
gene id: 115561:HHSLTHF2_RS12810
uniprot id: A0A291JPN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

115561:HHSLTHF2 RS02795
gene id: 115561:HHSLTHF2_RS02795
uniprot id: A0A6F8U198
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

115561:HHSLTHF2 RS07105
gene id: 115561:HHSLTHF2_RS07105
uniprot id: A0A6F8U2Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

115561:HHSLTHF2 RS17955
gene id: 115561:HHSLTHF2_RS17955
uniprot id: A0A6F8U9S2
names: Subcellular Location Annotation
messages: Membrane

115561:HHSLTHF2 RS08810
gene id: 115561:HHSLTHF2_RS08810
uniprot id: A0A6F8U306
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

115561:HHSLTHF2 RS06380
gene id: 115561:HHSLTHF2_RS06380
uniprot id: A0A6F8U362
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

115561:HHSLTHF2 RS18350
gene id: 115561:HHSLTHF2_RS18350
uniprot id: A0A6F8U9D7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

115561:HHSLTHF2 RS00900
gene id: 115561:HHSLTHF2_RS00900
uniprot id: A0A291JRM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

115561:HHSLTHF2 RS00940
gene id: 115561:HHSLTHF2_RS00940
uniprot id: A0A291JRK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

115561:HHSLTHF2 RS01405
gene id: 115561:HHSLTHF2_RS01405
uniprot id: A0A6F8TYX0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

115561:HHSLTHF2 RS11240
gene id: 115561:HHSLTHF2_RS11240
uniprot id: A0A6F8U5Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

115561:HHSLTHF2 RS06310
gene id: 115561:HHSLTHF2_RS06310
uniprot id: A0A6F8U352
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

115561:HHSLTHF2 RS06370
gene id: 115561:HHSLTHF2_RS06370
uniprot id: A0A6F8U2H1
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.