1056495:CALAG RS02680
gene id: 1056495:CALAG_RS02680
uniprot id: L0A8V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1056495:CALAG RS05660
gene id: 1056495:CALAG_RS05660
uniprot id: L0ACU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS06845
gene id: 1056495:CALAG_RS06845
uniprot id: L0AB41
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS02040
gene id: 1056495:CALAG_RS02040
uniprot id: L0A8M5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1056495:CALAG RS03275
gene id: 1056495:CALAG_RS03275
uniprot id: L0A951
names: Subcellular Location Annotation
messages: Cytoplasm

1056495:CALAG RS06350
gene id: 1056495:CALAG_RS06350
uniprot id: L0AD87
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1056495:CALAG RS06295
gene id: 1056495:CALAG_RS06295
uniprot id: L0AAQ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

1056495:CALAG RS05730
gene id: 1056495:CALAG_RS05730
uniprot id: L0ABT8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1056495:CALAG RS02375
gene id: 1056495:CALAG_RS02375
uniprot id: L0A8S8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1056495:CALAG RS05315
gene id: 1056495:CALAG_RS05315
uniprot id: L0ACE9
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS03550
gene id: 1056495:CALAG_RS03550
uniprot id: L0ABQ3
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

1056495:CALAG RS06525
gene id: 1056495:CALAG_RS06525
uniprot id: L0ADB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1056495:CALAG RS03545
gene id: 1056495:CALAG_RS03545
uniprot id: L0AAM2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS05605
gene id: 1056495:CALAG_RS05605
uniprot id: L0ACT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1056495:CALAG RS00800
gene id: 1056495:CALAG_RS00800
uniprot id: L0A7V3
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1056495:CALAG RS06475
gene id: 1056495:CALAG_RS06475
uniprot id: L0AD20
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1056495:CALAG RS05690
gene id: 1056495:CALAG_RS05690
uniprot id: L0AAH8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1056495:CALAG RS01150
gene id: 1056495:CALAG_RS01150
uniprot id: L0A9B9
names: Similarity
messages: Belongs to the RuvB family.

1056495:CALAG RS03715
gene id: 1056495:CALAG_RS03715
uniprot id: L0ABK1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1056495:CALAG RS05720
gene id: 1056495:CALAG_RS05720
uniprot id: L0ACL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1056495:CALAG RS06570
gene id: 1056495:CALAG_RS06570
uniprot id: L0ACA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1056495:CALAG RS05310
gene id: 1056495:CALAG_RS05310
uniprot id: L0AAB5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1056495:CALAG RS00765
gene id: 1056495:CALAG_RS00765
uniprot id: L0A7Y7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1056495:CALAG RS00220
gene id: 1056495:CALAG_RS00220
uniprot id: L0A7J0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1056495:CALAG RS01625
gene id: 1056495:CALAG_RS01625
uniprot id: L0A8G5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1056495:CALAG RS06545
gene id: 1056495:CALAG_RS06545
uniprot id: L0AC95
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

1056495:CALAG RS00565
gene id: 1056495:CALAG_RS00565
uniprot id: L0A9T7
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1056495:CALAG RS06705
gene id: 1056495:CALAG_RS06705
uniprot id: L0AB23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1056495:CALAG RS05950
gene id: 1056495:CALAG_RS05950
uniprot id: L0AAM6
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1056495:CALAG RS06915
gene id: 1056495:CALAG_RS06915
uniprot id: L0ADD4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1056495:CALAG RS07570
gene id: 1056495:CALAG_RS07570
uniprot id: L0ABK7
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1056495:CALAG RS01400
gene id: 1056495:CALAG_RS01400
uniprot id: L0A873
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1056495:CALAG RS00270
gene id: 1056495:CALAG_RS00270
uniprot id: L0A7J9
names: Similarity
messages: Belongs to the Ahb/Nir family.

1056495:CALAG RS00365
gene id: 1056495:CALAG_RS00365
uniprot id: L0A7R2
names: Similarity
messages: Belongs to the arginase family.

1056495:CALAG RS02780
gene id: 1056495:CALAG_RS02780
uniprot id: L0A8W8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1056495:CALAG RS03080
gene id: 1056495:CALAG_RS03080
uniprot id: L0A942
names: Similarity
messages: Belongs to the pyruvate kinase family.

1056495:CALAG RS00910
gene id: 1056495:CALAG_RS00910
uniprot id: L0AA13
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS00010
gene id: 1056495:CALAG_RS00010
uniprot id: L0A7F3
names: Similarity
messages: Belongs to the UPF0215 family.

1056495:CALAG RS06145
gene id: 1056495:CALAG_RS06145
uniprot id: L0AAN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

1056495:CALAG RS01350
gene id: 1056495:CALAG_RS01350
uniprot id: L0A863
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS06745
gene id: 1056495:CALAG_RS06745
uniprot id: L0ACE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1056495:CALAG RS00165
gene id: 1056495:CALAG_RS00165
uniprot id: L0A8T3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1056495:CALAG RS07190
gene id: 1056495:CALAG_RS07190
uniprot id: L0ABA4
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS07555
gene id: 1056495:CALAG_RS07555
uniprot id: L0ABG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1056495:CALAG RS07130
gene id: 1056495:CALAG_RS07130
uniprot id: L0AB93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1056495:CALAG RS05640
gene id: 1056495:CALAG_RS05640
uniprot id: L0ACK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1056495:CALAG RS05355
gene id: 1056495:CALAG_RS05355
uniprot id: L0ACN5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1056495:CALAG RS01070
gene id: 1056495:CALAG_RS01070
uniprot id: L0A807
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1056495:CALAG RS05710
gene id: 1056495:CALAG_RS05710
uniprot id: L0ACV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1056495:CALAG RS02675
gene id: 1056495:CALAG_RS02675
uniprot id: L0AAZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1056495:CALAG RS05910
gene id: 1056495:CALAG_RS05910
uniprot id: L0AAI5
names: Similarity
messages: Belongs to the diphthine synthase family.

1056495:CALAG RS05770
gene id: 1056495:CALAG_RS05770
uniprot id: L0ACM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS06795
gene id: 1056495:CALAG_RS06795
uniprot id: L0ACG5
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1056495:CALAG RS02720
gene id: 1056495:CALAG_RS02720
uniprot id: L0A8X9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1056495:CALAG RS03710
gene id: 1056495:CALAG_RS03710
uniprot id: L0A9F8
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS05615
gene id: 1056495:CALAG_RS05615
uniprot id: L0ACJ9
names: Similarity
messages: Belongs to the PGI/PMI family.

1056495:CALAG RS02695
gene id: 1056495:CALAG_RS02695
uniprot id: L0A8X7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS04350
gene id: 1056495:CALAG_RS04350
uniprot id: L0A9R6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1056495:CALAG RS05945
gene id: 1056495:CALAG_RS05945
uniprot id: L0AD05
names: Subcellular Location Annotation
messages: Nucleus

1056495:CALAG RS03595
gene id: 1056495:CALAG_RS03595
uniprot id: L0A9A6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1056495:CALAG RS01595
gene id: 1056495:CALAG_RS01595
uniprot id: L0AAR1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1056495:CALAG RS04765
gene id: 1056495:CALAG_RS04765
uniprot id: L0ABA8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1056495:CALAG RS02430
gene id: 1056495:CALAG_RS02430
uniprot id: L0AAW0
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1056495:CALAG RS02125
gene id: 1056495:CALAG_RS02125
uniprot id: L0A8K8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1056495:CALAG RS02515
gene id: 1056495:CALAG_RS02515
uniprot id: L0AAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1056495:CALAG RS00155
gene id: 1056495:CALAG_RS00155
uniprot id: L0A9L1
names: Similarity
messages: Belongs to the UPF0282 family.

1056495:CALAG RS02685
gene id: 1056495:CALAG_RS02685
uniprot id: L0AA59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1056495:CALAG RS05360
gene id: 1056495:CALAG_RS05360
uniprot id: L0AAC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1056495:CALAG RS06855
gene id: 1056495:CALAG_RS06855
uniprot id: L0ADK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS00500
gene id: 1056495:CALAG_RS00500
uniprot id: L0A8Z3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS06515
gene id: 1056495:CALAG_RS06515
uniprot id: L0AAV1
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS05215
gene id: 1056495:CALAG_RS05215
uniprot id: L0ACD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1056495:CALAG RS01130
gene id: 1056495:CALAG_RS01130
uniprot id: L0AAE8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1056495:CALAG RS00900
gene id: 1056495:CALAG_RS00900
uniprot id: L0A813
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1056495:CALAG RS02055
gene id: 1056495:CALAG_RS02055
uniprot id: L0AAY6
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1056495:CALAG RS00960
gene id: 1056495:CALAG_RS00960
uniprot id: L0A824
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS01960
gene id: 1056495:CALAG_RS01960
uniprot id: L0A8L4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1056495:CALAG RS02360
gene id: 1056495:CALAG_RS02360
uniprot id: L0A8Q0
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1056495:CALAG RS05365
gene id: 1056495:CALAG_RS05365
uniprot id: L0ACF5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1056495:CALAG RS04110
gene id: 1056495:CALAG_RS04110
uniprot id: L0A9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

1056495:CALAG RS06730
gene id: 1056495:CALAG_RS06730
uniprot id: L0AB42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1056495:CALAG RS06800
gene id: 1056495:CALAG_RS06800
uniprot id: L0ADJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1056495:CALAG RS01590
gene id: 1056495:CALAG_RS01590
uniprot id: L0A9M8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS07380
gene id: 1056495:CALAG_RS07380
uniprot id: L0ADT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS05705
gene id: 1056495:CALAG_RS05705
uniprot id: L0ABT5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

1056495:CALAG RS05320
gene id: 1056495:CALAG_RS05320
uniprot id: L0AA81
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS06595
gene id: 1056495:CALAG_RS06595
uniprot id: L0ACA5
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS02280
gene id: 1056495:CALAG_RS02280
uniprot id: L0AAT2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1056495:CALAG RS03235
gene id: 1056495:CALAG_RS03235
uniprot id: L0A969
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1056495:CALAG RS01565
gene id: 1056495:CALAG_RS01565
uniprot id: L0A9M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1056495:CALAG RS03395
gene id: 1056495:CALAG_RS03395
uniprot id: L0AAI8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1056495:CALAG RS04850
gene id: 1056495:CALAG_RS04850
uniprot id: L0AA36
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1056495:CALAG RS05865
gene id: 1056495:CALAG_RS05865
uniprot id: L0ABW0
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1056495:CALAG RS06910
gene id: 1056495:CALAG_RS06910
uniprot id: L0AB86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

1056495:CALAG RS01105
gene id: 1056495:CALAG_RS01105
uniprot id: L0AAE4
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

1056495:CALAG RS07045
gene id: 1056495:CALAG_RS07045
uniprot id: L0ADF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1056495:CALAG RS00130
gene id: 1056495:CALAG_RS00130
uniprot id: L0A7M4
names: Similarity
messages: Belongs to the UPF0145 family.

1056495:CALAG RS07145
gene id: 1056495:CALAG_RS07145
uniprot id: L0ABD3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1056495:CALAG RS05815
gene id: 1056495:CALAG_RS05815
uniprot id: L0ACX9
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

1056495:CALAG RS04705
gene id: 1056495:CALAG_RS04705
uniprot id: L0AA10
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1056495:CALAG RS02495
gene id: 1056495:CALAG_RS02495
uniprot id: L0A8S1
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

1056495:CALAG RS01075
gene id: 1056495:CALAG_RS01075
uniprot id: L0A9A4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS04625
gene id: 1056495:CALAG_RS04625
uniprot id: L0AB85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1056495:CALAG RS01800
gene id: 1056495:CALAG_RS01800
uniprot id: L0A9Q6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1056495:CALAG RS01615
gene id: 1056495:CALAG_RS01615
uniprot id: L0A9N2
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS07590
gene id: 1056495:CALAG_RS07590
uniprot id: L0ADX1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS06980
gene id: 1056495:CALAG_RS06980
uniprot id: L0ADM4
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1056495:CALAG RS06260
gene id: 1056495:CALAG_RS06260
uniprot id: L0AAT5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1056495:CALAG RS06540
gene id: 1056495:CALAG_RS06540
uniprot id: L0AAV6
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS00475
gene id: 1056495:CALAG_RS00475
uniprot id: L0A8Z0
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

1056495:CALAG RS03705
gene id: 1056495:CALAG_RS03705
uniprot id: L0ABT1
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS02775
gene id: 1056495:CALAG_RS02775
uniprot id: L0AB11
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS00030
gene id: 1056495:CALAG_RS00030
uniprot id: L0A7F5
names: Caution
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS07160
gene id: 1056495:CALAG_RS07160
uniprot id: L0ABA0
names: Similarity
messages: Belongs to the UPF0047 family.

1056495:CALAG RS04845
gene id: 1056495:CALAG_RS04845
uniprot id: L0ACE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1056495:CALAG RS02245
gene id: 1056495:CALAG_RS02245
uniprot id: L0A8Q9
names: Subunit
messages: Homodimer.

1056495:CALAG RS01630
gene id: 1056495:CALAG_RS01630
uniprot id: L0AAJ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS06710
gene id: 1056495:CALAG_RS06710
uniprot id: L0AD69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS07620
gene id: 1056495:CALAG_RS07620
uniprot id: L0ABL5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1056495:CALAG RS02700
gene id: 1056495:CALAG_RS02700
uniprot id: L0AB02
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1056495:CALAG RS05630
gene id: 1056495:CALAG_RS05630
uniprot id: L0ACU3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1056495:CALAG RS06840
gene id: 1056495:CALAG_RS06840
uniprot id: L0ADC0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS04980
gene id: 1056495:CALAG_RS04980
uniprot id: L0ACG6
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1056495:CALAG RS02690
gene id: 1056495:CALAG_RS02690
uniprot id: L0AB82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS01995
gene id: 1056495:CALAG_RS01995
uniprot id: L0AAP2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

1056495:CALAG RS00420
gene id: 1056495:CALAG_RS00420
uniprot id: L0A9Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1056495:CALAG RS07185
gene id: 1056495:CALAG_RS07185
uniprot id: L0ADH2
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS01165
gene id: 1056495:CALAG_RS01165
uniprot id: L0AA71
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS07020
gene id: 1056495:CALAG_RS07020
uniprot id: L0AB76
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS03105
gene id: 1056495:CALAG_RS03105
uniprot id: L0A948
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS01860
gene id: 1056495:CALAG_RS01860
uniprot id: L0A9R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1056495:CALAG RS03375
gene id: 1056495:CALAG_RS03375
uniprot id: L0AAI2
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS06370
gene id: 1056495:CALAG_RS06370
uniprot id: L0AAS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1056495:CALAG RS02600
gene id: 1056495:CALAG_RS02600
uniprot id: L0AAY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

1056495:CALAG RS01750
gene id: 1056495:CALAG_RS01750
uniprot id: L0AAU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1056495:CALAG RS06685
gene id: 1056495:CALAG_RS06685
uniprot id: L0AD63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1056495:CALAG RS01650
gene id: 1056495:CALAG_RS01650
uniprot id: L0A8G9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1056495:CALAG RS05875
gene id: 1056495:CALAG_RS05875
uniprot id: L0AAL3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS01855
gene id: 1056495:CALAG_RS01855
uniprot id: L0A8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1056495:CALAG RS05135
gene id: 1056495:CALAG_RS05135
uniprot id: L0AA86
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

1056495:CALAG RS00840
gene id: 1056495:CALAG_RS00840
uniprot id: L0A802
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS01090
gene id: 1056495:CALAG_RS01090
uniprot id: L0AA55
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1056495:CALAG RS03615
gene id: 1056495:CALAG_RS03615
uniprot id: L0ABH7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1056495:CALAG RS02145
gene id: 1056495:CALAG_RS02145
uniprot id: L0AAR3
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS04860
gene id: 1056495:CALAG_RS04860
uniprot id: L0A9Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1056495:CALAG RS04235
gene id: 1056495:CALAG_RS04235
uniprot id: L0AC57
names: Similarity
messages: Belongs to the class-I fumarase family.

1056495:CALAG RS01815
gene id: 1056495:CALAG_RS01815
uniprot id: L0AAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

1056495:CALAG RS06720
gene id: 1056495:CALAG_RS06720
uniprot id: L0ACD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1056495:CALAG RS07390
gene id: 1056495:CALAG_RS07390
uniprot id: L0ABH5
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1056495:CALAG RS06070
gene id: 1056495:CALAG_RS06070
uniprot id: L0AD31
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1056495:CALAG RS04935
gene id: 1056495:CALAG_RS04935
uniprot id: L0AA50
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

1056495:CALAG RS00645
gene id: 1056495:CALAG_RS00645
uniprot id: L0A7S4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1056495:CALAG RS07090
gene id: 1056495:CALAG_RS07090
uniprot id: L0ADP1
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1056495:CALAG RS07625
gene id: 1056495:CALAG_RS07625
uniprot id: L0ADP6
names: Similarity
messages: Belongs to the GcvT family.

1056495:CALAG RS05065
gene id: 1056495:CALAG_RS05065
uniprot id: L0ACA3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1056495:CALAG RS06975
gene id: 1056495:CALAG_RS06975
uniprot id: L0ACJ3
names: Similarity
messages: Belongs to the complex I subunit 3 family.

1056495:CALAG RS05485
gene id: 1056495:CALAG_RS05485
uniprot id: L0AAE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1056495:CALAG RS00150
gene id: 1056495:CALAG_RS00150
uniprot id: L0A7M8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

1056495:CALAG RS04265
gene id: 1056495:CALAG_RS04265
uniprot id: L0A9U0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1056495:CALAG RS00385
gene id: 1056495:CALAG_RS00385
uniprot id: L0A9Y9
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS02530
gene id: 1056495:CALAG_RS02530
uniprot id: L0AB53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1056495:CALAG RS03210
gene id: 1056495:CALAG_RS03210
uniprot id: L0A965
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1056495:CALAG RS05400
gene id: 1056495:CALAG_RS05400
uniprot id: L0ABM8
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS01545
gene id: 1056495:CALAG_RS01545
uniprot id: L0AAQ0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1056495:CALAG RS00200
gene id: 1056495:CALAG_RS00200
uniprot id: L0A8T8
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS04760
gene id: 1056495:CALAG_RS04760
uniprot id: L0A9Y0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1056495:CALAG RS02790
gene id: 1056495:CALAG_RS02790
uniprot id: L0ABA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1056495:CALAG RS07650
gene id: 1056495:CALAG_RS07650
uniprot id: L0ADQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1056495:CALAG RS03495
gene id: 1056495:CALAG_RS03495
uniprot id: L0AAL0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1056495:CALAG RS05445
gene id: 1056495:CALAG_RS05445
uniprot id: L0AAA4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1056495:CALAG RS00260
gene id: 1056495:CALAG_RS00260
uniprot id: L0A7P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1056495:CALAG RS01560
gene id: 1056495:CALAG_RS01560
uniprot id: L0A8C2
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

1056495:CALAG RS05590
gene id: 1056495:CALAG_RS05590
uniprot id: L0ACJ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

1056495:CALAG RS05735
gene id: 1056495:CALAG_RS05735
uniprot id: L0ACW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1056495:CALAG RS01720
gene id: 1056495:CALAG_RS01720
uniprot id: L0A9P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1056495:CALAG RS03910
gene id: 1056495:CALAG_RS03910
uniprot id: L0ABX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1056495:CALAG RS00225
gene id: 1056495:CALAG_RS00225
uniprot id: L0A8U3
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1056495:CALAG RS01880
gene id: 1056495:CALAG_RS01880
uniprot id: L0A8H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1056495:CALAG RS05900
gene id: 1056495:CALAG_RS05900
uniprot id: L0AAL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1056495:CALAG RS00295
gene id: 1056495:CALAG_RS00295
uniprot id: L0A9N1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS07410
gene id: 1056495:CALAG_RS07410
uniprot id: L0ADU2
names: Similarity
messages: Belongs to the peptidase S45 family.

1056495:CALAG RS02445
gene id: 1056495:CALAG_RS02445
uniprot id: L0AB39
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1056495:CALAG RS02110
gene id: 1056495:CALAG_RS02110
uniprot id: L0AAZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

1056495:CALAG RS03010
gene id: 1056495:CALAG_RS03010
uniprot id: L0AB50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

1056495:CALAG RS00145
gene id: 1056495:CALAG_RS00145
uniprot id: L0A9U3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1056495:CALAG RS02970
gene id: 1056495:CALAG_RS02970
uniprot id: L0AAB3
names: Similarity
messages: Belongs to the HerA family.

1056495:CALAG RS02100
gene id: 1056495:CALAG_RS02100
uniprot id: L0A8K4
names: Function
messages: Probably involved in the biogenesis of the ribosome.

1056495:CALAG RS06765
gene id: 1056495:CALAG_RS06765
uniprot id: L0AB25
names: Similarity
messages: Belongs to the glutaredoxin family.

1056495:CALAG RS04015
gene id: 1056495:CALAG_RS04015
uniprot id: L0ABQ9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

1056495:CALAG RS00480
gene id: 1056495:CALAG_RS00480
uniprot id: L0AA12
names: Similarity
messages: Belongs to the TrpF family.

1056495:CALAG RS02590
gene id: 1056495:CALAG_RS02590
uniprot id: L0AB64
names: Subcellular Location Annotation
messages: Nucleus

1056495:CALAG RS01490
gene id: 1056495:CALAG_RS01490
uniprot id: L0AAM1
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS04620
gene id: 1056495:CALAG_RS04620
uniprot id: L0A9V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1056495:CALAG RS02130
gene id: 1056495:CALAG_RS02130
uniprot id: L0A9V6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1056495:CALAG RS03315
gene id: 1056495:CALAG_RS03315
uniprot id: L0AAH2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1056495:CALAG RS05635
gene id: 1056495:CALAG_RS05635
uniprot id: L0AAG9
names: Similarity
messages: Belongs to the HMBS family.

1056495:CALAG RS03260
gene id: 1056495:CALAG_RS03260
uniprot id: L0ABJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1056495:CALAG RS05890
gene id: 1056495:CALAG_RS05890
uniprot id: L0ABW4
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1056495:CALAG RS06375
gene id: 1056495:CALAG_RS06375
uniprot id: L0AC58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1056495:CALAG RS05480
gene id: 1056495:CALAG_RS05480
uniprot id: L0ACR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1056495:CALAG RS06735
gene id: 1056495:CALAG_RS06735
uniprot id: L0AD86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1056495:CALAG RS00490
gene id: 1056495:CALAG_RS00490
uniprot id: L0A9S0
names: Function
names: Similarity
messages: Belongs to the TrpA family.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1056495:CALAG RS06270
gene id: 1056495:CALAG_RS06270
uniprot id: L0AAQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1056495:CALAG RS06395
gene id: 1056495:CALAG_RS06395
uniprot id: L0AAT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1056495:CALAG RS02845
gene id: 1056495:CALAG_RS02845
uniprot id: L0ABB1
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

1056495:CALAG RS01085
gene id: 1056495:CALAG_RS01085
uniprot id: L0A847
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

1056495:CALAG RS05455
gene id: 1056495:CALAG_RS05455
uniprot id: L0ACQ5
names: Similarity
messages: Belongs to the SUI1 family.

1056495:CALAG RS06750
gene id: 1056495:CALAG_RS06750
uniprot id: L0ADH6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS05940
gene id: 1056495:CALAG_RS05940
uniprot id: L0ABX3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1056495:CALAG RS00810
gene id: 1056495:CALAG_RS00810
uniprot id: L0AA84
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS02635
gene id: 1056495:CALAG_RS02635
uniprot id: L0AA48
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS06345
gene id: 1056495:CALAG_RS06345
uniprot id: L0AC53
names: Similarity
messages: Belongs to the AOR/FOR family.

1056495:CALAG RS02350
gene id: 1056495:CALAG_RS02350
uniprot id: L0A8S5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1056495:CALAG RS01470
gene id: 1056495:CALAG_RS01470
uniprot id: L0A8B6
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1056495:CALAG RS04645
gene id: 1056495:CALAG_RS04645
uniprot id: L0A9W3
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS05680
gene id: 1056495:CALAG_RS05680
uniprot id: L0ABT2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1056495:CALAG RS02645
gene id: 1056495:CALAG_RS02645
uniprot id: L0A8W9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

1056495:CALAG RS01440
gene id: 1056495:CALAG_RS01440
uniprot id: L0A8B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1056495:CALAG RS03030
gene id: 1056495:CALAG_RS03030
uniprot id: L0A932
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1056495:CALAG RS04050
gene id: 1056495:CALAG_RS04050
uniprot id: L0AAY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1056495:CALAG RS02355
gene id: 1056495:CALAG_RS02355
uniprot id: L0AAU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1056495:CALAG RS07010
gene id: 1056495:CALAG_RS07010
uniprot id: L0ABA5
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS07330
gene id: 1056495:CALAG_RS07330
uniprot id: L0ACP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS03620
gene id: 1056495:CALAG_RS03620
uniprot id: L0A9B2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1056495:CALAG RS06315
gene id: 1056495:CALAG_RS06315
uniprot id: L0ACZ1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1056495:CALAG RS02240
gene id: 1056495:CALAG_RS02240
uniprot id: L0AB07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1056495:CALAG RS01575
gene id: 1056495:CALAG_RS01575
uniprot id: L0A8F8
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

1056495:CALAG RS04210
gene id: 1056495:CALAG_RS04210
uniprot id: L0AC52
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS01820
gene id: 1056495:CALAG_RS01820
uniprot id: L0A8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

1056495:CALAG RS05880
gene id: 1056495:CALAG_RS05880
uniprot id: L0ACP9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1056495:CALAG RS00570
gene id: 1056495:CALAG_RS00570
uniprot id: L0A7R1
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS00495
gene id: 1056495:CALAG_RS00495
uniprot id: L0A7P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1056495:CALAG RS00845
gene id: 1056495:CALAG_RS00845
uniprot id: L0AA02
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1056495:CALAG RS03790
gene id: 1056495:CALAG_RS03790
uniprot id: L0A9H5
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1056495:CALAG RS04960
gene id: 1056495:CALAG_RS04960
uniprot id: L0AA53
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1056495:CALAG RS02135
gene id: 1056495:CALAG_RS02135
uniprot id: L0AAZ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1056495:CALAG RS06660
gene id: 1056495:CALAG_RS06660
uniprot id: L0AD57
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1056495:CALAG RS07075
gene id: 1056495:CALAG_RS07075
uniprot id: L0ADF9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1056495:CALAG RS00660
gene id: 1056495:CALAG_RS00660
uniprot id: L0A7W6
names: Similarity
messages: Belongs to the peptidase C15 family.

1056495:CALAG RS02705
gene id: 1056495:CALAG_RS02705
uniprot id: L0A8V5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1056495:CALAG RS06220
gene id: 1056495:CALAG_RS06220
uniprot id: L0AC30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1056495:CALAG RS03150
gene id: 1056495:CALAG_RS03150
uniprot id: L0A929
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1056495:CALAG RS05345
gene id: 1056495:CALAG_RS05345
uniprot id: L0AA85
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1056495:CALAG RS05745
gene id: 1056495:CALAG_RS05745
uniprot id: L0ACM3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1056495:CALAG RS05460
gene id: 1056495:CALAG_RS05460
uniprot id: L0AAE3
names: Similarity
messages: Belongs to the UPF0284 family.

1056495:CALAG RS06875
gene id: 1056495:CALAG_RS06875
uniprot id: L0ACH9
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS01515
gene id: 1056495:CALAG_RS01515
uniprot id: L0AAN9
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1056495:CALAG RS01825
gene id: 1056495:CALAG_RS01825
uniprot id: L0AAM0
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

1056495:CALAG RS01270
gene id: 1056495:CALAG_RS01270
uniprot id: L0A846
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS06290
gene id: 1056495:CALAG_RS06290
uniprot id: L0ACY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1056495:CALAG RS01080
gene id: 1056495:CALAG_RS01080
uniprot id: L0AAD8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

1056495:CALAG RS04240
gene id: 1056495:CALAG_RS04240
uniprot id: L0A9T5
names: Similarity
messages: Belongs to the class-I fumarase family.

1056495:CALAG RS06740
gene id: 1056495:CALAG_RS06740
uniprot id: L0AB13
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1056495:CALAG RS01765
gene id: 1056495:CALAG_RS01765
uniprot id: L0A8F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS05580
gene id: 1056495:CALAG_RS05580
uniprot id: L0ACT2
names: Similarity
messages: Belongs to the AOR/FOR family.

1056495:CALAG RS02395
gene id: 1056495:CALAG_RS02395
uniprot id: L0AB33
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1056495:CALAG RS04415
gene id: 1056495:CALAG_RS04415
uniprot id: L0AB52
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1056495:CALAG RS06445
gene id: 1056495:CALAG_RS06445
uniprot id: L0AD16
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1056495:CALAG RS00020
gene id: 1056495:CALAG_RS00020
uniprot id: L0A9R5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

1056495:CALAG RS01975
gene id: 1056495:CALAG_RS01975
uniprot id: L0A9T0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS03255
gene id: 1056495:CALAG_RS03255
uniprot id: L0AAG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1056495:CALAG RS03445
gene id: 1056495:CALAG_RS03445
uniprot id: L0AAJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1056495:CALAG RS04810
gene id: 1056495:CALAG_RS04810
uniprot id: L0A9Y8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1056495:CALAG RS07205
gene id: 1056495:CALAG_RS07205
uniprot id: L0ABE3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1056495:CALAG RS07340
gene id: 1056495:CALAG_RS07340
uniprot id: L0ABG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS02830
gene id: 1056495:CALAG_RS02830
uniprot id: L0AB21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1056495:CALAG RS02325
gene id: 1056495:CALAG_RS02325
uniprot id: L0A8S0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1056495:CALAG RS00060
gene id: 1056495:CALAG_RS00060
uniprot id: L0A8R4
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1056495:CALAG RS04180
gene id: 1056495:CALAG_RS04180
uniprot id: L0AB19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1056495:CALAG RS02205
gene id: 1056495:CALAG_RS02205
uniprot id: L0AAM2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1056495:CALAG RS03460
gene id: 1056495:CALAG_RS03460
uniprot id: L0ABE4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1056495:CALAG RS07580
gene id: 1056495:CALAG_RS07580
uniprot id: L0ABH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1056495:CALAG RS04030
gene id: 1056495:CALAG_RS04030
uniprot id: L0ABZ6
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1056495:CALAG RS02215
gene id: 1056495:CALAG_RS02215
uniprot id: L0AB05
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1056495:CALAG RS05955
gene id: 1056495:CALAG_RS05955
uniprot id: L0ACR4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1056495:CALAG RS04250
gene id: 1056495:CALAG_RS04250
uniprot id: L0A9Q1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1056495:CALAG RS01585
gene id: 1056495:CALAG_RS01585
uniprot id: L0A8C5
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS03920
gene id: 1056495:CALAG_RS03920
uniprot id: L0ABP5
names: Similarity
messages: Belongs to the DtxR/MntR family.

1056495:CALAG RS00855
gene id: 1056495:CALAG_RS00855
uniprot id: L0A963
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS05740
gene id: 1056495:CALAG_RS05740
uniprot id: L0AAI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1056495:CALAG RS06495
gene id: 1056495:CALAG_RS06495
uniprot id: L0AC83
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS01755
gene id: 1056495:CALAG_RS01755
uniprot id: L0A8I5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1056495:CALAG RS02000
gene id: 1056495:CALAG_RS02000
uniprot id: L0A8I7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1056495:CALAG RS01840
gene id: 1056495:CALAG_RS01840
uniprot id: L0AAV5
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1056495:CALAG RS02255
gene id: 1056495:CALAG_RS02255
uniprot id: L0A8N1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1056495:CALAG RS06560
gene id: 1056495:CALAG_RS06560
uniprot id: L0AD37
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1056495:CALAG RS06755
gene id: 1056495:CALAG_RS06755
uniprot id: L0AB56
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

1056495:CALAG RS03610
gene id: 1056495:CALAG_RS03610
uniprot id: L0A9D7
names: Subcellular Location Annotation
messages: nucleolus

1056495:CALAG RS02190
gene id: 1056495:CALAG_RS02190
uniprot id: L0AB03
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1056495:CALAG RS05885
gene id: 1056495:CALAG_RS05885
uniprot id: L0AAI0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1056495:CALAG RS06890
gene id: 1056495:CALAG_RS06890
uniprot id: L0ADD0
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1056495:CALAG RS05095
gene id: 1056495:CALAG_RS05095
uniprot id: L0AA37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1056495:CALAG RS07350
gene id: 1056495:CALAG_RS07350
uniprot id: L0ABD0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

1056495:CALAG RS00460
gene id: 1056495:CALAG_RS00460
uniprot id: L0A7T0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1056495:CALAG RS06610
gene id: 1056495:CALAG_RS06610
uniprot id: L0AD48
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1056495:CALAG RS05625
gene id: 1056495:CALAG_RS05625
uniprot id: L0ABS0
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1056495:CALAG RS03230
gene id: 1056495:CALAG_RS03230
uniprot id: L0ABJ0
names: Similarity
messages: Belongs to the MCM family.

1056495:CALAG RS05670
gene id: 1056495:CALAG_RS05670
uniprot id: L0ACK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

1056495:CALAG RS05100
gene id: 1056495:CALAG_RS05100
uniprot id: L0ABH2
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1056495:CALAG RS00485
gene id: 1056495:CALAG_RS00485
uniprot id: L0A7T4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS02105
gene id: 1056495:CALAG_RS02105
uniprot id: L0A9V1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

1056495:CALAG RS06530
gene id: 1056495:CALAG_RS06530
uniprot id: L0AAZ2
names: Similarity
messages: Belongs to the carbamate kinase family.

1056495:CALAG RS01645
gene id: 1056495:CALAG_RS01645
uniprot id: L0AAS6
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

1056495:CALAG RS01795
gene id: 1056495:CALAG_RS01795
uniprot id: L0A8F9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1056495:CALAG RS06215
gene id: 1056495:CALAG_RS06215
uniprot id: L0AAP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1056495:CALAG RS07560
gene id: 1056495:CALAG_RS07560
uniprot id: L0ACU0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1056495:CALAG RS07395
gene id: 1056495:CALAG_RS07395
uniprot id: L0ADK6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS01735
gene id: 1056495:CALAG_RS01735
uniprot id: L0AAK8
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

1056495:CALAG RS05960
gene id: 1056495:CALAG_RS05960
uniprot id: L0AAJ5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1056495:CALAG RS00080
gene id: 1056495:CALAG_RS00080
uniprot id: L0A7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1056495:CALAG RS01355
gene id: 1056495:CALAG_RS01355
uniprot id: L0A9G2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1056495:CALAG RS02520
gene id: 1056495:CALAG_RS02520
uniprot id: L0A8S6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1056495:CALAG RS06810
gene id: 1056495:CALAG_RS06810
uniprot id: L0ADB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

1056495:CALAG RS03880
gene id: 1056495:CALAG_RS03880
uniprot id: L0AAU2
names: Similarity
messages: Belongs to the acylphosphatase family.

1056495:CALAG RS01005
gene id: 1056495:CALAG_RS01005
uniprot id: L0AAC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1056495:CALAG RS06075
gene id: 1056495:CALAG_RS06075
uniprot id: L0AAP9
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

1056495:CALAG RS01610
gene id: 1056495:CALAG_RS01610
uniprot id: L0A8C8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS02410
gene id: 1056495:CALAG_RS02410
uniprot id: U3GLC7
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.

1056495:CALAG RS06150
gene id: 1056495:CALAG_RS06150
uniprot id: L0AC17
names: Similarity
messages: Belongs to the HypE family.

1056495:CALAG RS01360
gene id: 1056495:CALAG_RS01360
uniprot id: L0AAJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1056495:CALAG RS06425
gene id: 1056495:CALAG_RS06425
uniprot id: L0AAT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

1056495:CALAG RS06355
gene id: 1056495:CALAG_RS06355
uniprot id: L0AAV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1056495:CALAG RS04115
gene id: 1056495:CALAG_RS04115
uniprot id: L0ABU7
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

1056495:CALAG RS07280
gene id: 1056495:CALAG_RS07280
uniprot id: L0ADS1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1056495:CALAG RS05405
gene id: 1056495:CALAG_RS05405
uniprot id: L0ACP6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1056495:CALAG RS03830
gene id: 1056495:CALAG_RS03830
uniprot id: L0AAT1
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1056495:CALAG RS00005
gene id: 1056495:CALAG_RS00005
uniprot id: L0A9I8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1056495:CALAG RS02770
gene id: 1056495:CALAG_RS02770
uniprot id: L0A8Y7
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS06805
gene id: 1056495:CALAG_RS06805
uniprot id: L0AB62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1056495:CALAG RS01375
gene id: 1056495:CALAG_RS01375
uniprot id: L0A868
names: Similarity
messages: Belongs to the pirin family.

1056495:CALAG RS07115
gene id: 1056495:CALAG_RS07115
uniprot id: L0ADP5
names: Similarity
messages: Belongs to the UPF0201 family.

1056495:CALAG RS05440
gene id: 1056495:CALAG_RS05440
uniprot id: L0ACG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

1056495:CALAG RS02230
gene id: 1056495:CALAG_RS02230
uniprot id: L0A8M6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1056495:CALAG RS07360
gene id: 1056495:CALAG_RS07360
uniprot id: L0ABH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1056495:CALAG RS03995
gene id: 1056495:CALAG_RS03995
uniprot id: L0A9I9
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1056495:CALAG RS07615
gene id: 1056495:CALAG_RS07615
uniprot id: L0ADX6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1056495:CALAG RS02525
gene id: 1056495:CALAG_RS02525
uniprot id: L0AA30
names: Similarity
messages: Belongs to the SPT5 family.

1056495:CALAG RS04065
gene id: 1056495:CALAG_RS04065
uniprot id: L0ABS2
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS04900
gene id: 1056495:CALAG_RS04900
uniprot id: L0ACF6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

1056495:CALAG RS06565
gene id: 1056495:CALAG_RS06565
uniprot id: L0AAW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

1056495:CALAG RS03175
gene id: 1056495:CALAG_RS03175
uniprot id: L0A933
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

1056495:CALAG RS00465
gene id: 1056495:CALAG_RS00465
uniprot id: L0A9R4
names: Similarity
messages: Belongs to the TrpC family.

1056495:CALAG RS07375
gene id: 1056495:CALAG_RS07375
uniprot id: L0ACQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1056495:CALAG RS05935
gene id: 1056495:CALAG_RS05935
uniprot id: L0AAJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS00535
gene id: 1056495:CALAG_RS00535
uniprot id: L0A7U5
names: Similarity
messages: Belongs to the EPSP synthase family.

1056495:CALAG RS01930
gene id: 1056495:CALAG_RS01930
uniprot id: L0A8K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1056495:CALAG RS03365
gene id: 1056495:CALAG_RS03365
uniprot id: L0ABC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1056495:CALAG RS06135
gene id: 1056495:CALAG_RS06135
uniprot id: L0AAQ8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1056495:CALAG RS02390
gene id: 1056495:CALAG_RS02390
uniprot id: L0AA04
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

1056495:CALAG RS07085
gene id: 1056495:CALAG_RS07085
uniprot id: L0ACK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1056495:CALAG RS06970
gene id: 1056495:CALAG_RS06970
uniprot id: L0AB66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1056495:CALAG RS04970
gene id: 1056495:CALAG_RS04970
uniprot id: L0AA16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1056495:CALAG RS03930
gene id: 1056495:CALAG_RS03930
uniprot id: L0AAV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1056495:CALAG RS02710
gene id: 1056495:CALAG_RS02710
uniprot id: L0AA64
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1056495:CALAG RS02825
gene id: 1056495:CALAG_RS02825
uniprot id: L0A8Z6
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

1056495:CALAG RS02595
gene id: 1056495:CALAG_RS02595
uniprot id: L0A8W1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1056495:CALAG RS06015
gene id: 1056495:CALAG_RS06015
uniprot id: L0AAK3
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS05330
gene id: 1056495:CALAG_RS05330
uniprot id: L0ACN0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1056495:CALAG RS03505
gene id: 1056495:CALAG_RS03505
uniprot id: L0A9B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1056495:CALAG RS04205
gene id: 1056495:CALAG_RS04205
uniprot id: L0AB22
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS05395
gene id: 1056495:CALAG_RS05395
uniprot id: L0AA95
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1056495:CALAG RS05150
gene id: 1056495:CALAG_RS05150
uniprot id: L0ABI1
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

1056495:CALAG RS05450
gene id: 1056495:CALAG_RS05450
uniprot id: L0ABN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS06335
gene id: 1056495:CALAG_RS06335
uniprot id: L0AAV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1056495:CALAG RS05210
gene id: 1056495:CALAG_RS05210
uniprot id: L0AA98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1056495:CALAG RS00720
gene id: 1056495:CALAG_RS00720
uniprot id: L0A9X2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS04995
gene id: 1056495:CALAG_RS04995
uniprot id: L0AA21
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1056495:CALAG RS03895
gene id: 1056495:CALAG_RS03895
uniprot id: L0ABP0
names: Similarity
messages: Belongs to the UPF0248 family.

1056495:CALAG RS01040
gene id: 1056495:CALAG_RS01040
uniprot id: L0AA44
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1056495:CALAG RS07225
gene id: 1056495:CALAG_RS07225
uniprot id: L0ADR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1056495:CALAG RS06265
gene id: 1056495:CALAG_RS06265
uniprot id: L0ACX8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1056495:CALAG RS06500
gene id: 1056495:CALAG_RS06500
uniprot id: L0ADB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1056495:CALAG RS03660
gene id: 1056495:CALAG_RS03660
uniprot id: L0A9E8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1056495:CALAG RS05025
gene id: 1056495:CALAG_RS05025
uniprot id: L0ABF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1056495:CALAG RS04045
gene id: 1056495:CALAG_RS04045
uniprot id: L0A9J8
names: Similarity
messages: Belongs to the AOR/FOR family.

1056495:CALAG RS00740
gene id: 1056495:CALAG_RS00740
uniprot id: L0A7Y1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS03695
gene id: 1056495:CALAG_RS03695
uniprot id: L0A9C8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1056495:CALAG RS05830
gene id: 1056495:CALAG_RS05830
uniprot id: L0AAH1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS06940
gene id: 1056495:CALAG_RS06940
uniprot id: L0ADE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1056495:CALAG RS01940
gene id: 1056495:CALAG_RS01940
uniprot id: L0A8H8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1056495:CALAG RS06935
gene id: 1056495:CALAG_RS06935
uniprot id: L0AB91
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1056495:CALAG RS04305
gene id: 1056495:CALAG_RS04305
uniprot id: L0AB38
names: Similarity
messages: Belongs to the citrate synthase family.

1056495:CALAG RS01990
gene id: 1056495:CALAG_RS01990
uniprot id: L0A8L8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1056495:CALAG RS05915
gene id: 1056495:CALAG_RS05915
uniprot id: L0ABW9
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS07460
gene id: 1056495:CALAG_RS07460
uniprot id: L0ADV2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1056495:CALAG RS02715
gene id: 1056495:CALAG_RS02715
uniprot id: L0AB87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1056495:CALAG RS04280
gene id: 1056495:CALAG_RS04280
uniprot id: L0AB34
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

1056495:CALAG RS02115
gene id: 1056495:CALAG_RS02115
uniprot id: L0A8N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1056495:CALAG RS06995
gene id: 1056495:CALAG_RS06995
uniprot id: L0AB71
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS04575
gene id: 1056495:CALAG_RS04575
uniprot id: L0AC23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1056495:CALAG RS03430
gene id: 1056495:CALAG_RS03430
uniprot id: L0A9A3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1056495:CALAG RS05010
gene id: 1056495:CALAG_RS05010
uniprot id: L0AA62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

1056495:CALAG RS06465
gene id: 1056495:CALAG_RS06465
uniprot id: L0AAY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1056495:CALAG RS02120
gene id: 1056495:CALAG_RS02120
uniprot id: L0AAR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1056495:CALAG RS02750
gene id: 1056495:CALAG_RS02750
uniprot id: L0A8Y4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1056495:CALAG RS02140
gene id: 1056495:CALAG_RS02140
uniprot id: L0A8P3
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS02085
gene id: 1056495:CALAG_RS02085
uniprot id: L0AAY9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1056495:CALAG RS05510
gene id: 1056495:CALAG_RS05510
uniprot id: L0AAF0
names: Subcellular Location Annotation
messages: Membrane

1056495:CALAG RS00730
gene id: 1056495:CALAG_RS00730
uniprot id: U3GK32
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Heterodimer composed of an alpha and a beta subunit.

1056495:CALAG RS02175
gene id: 1056495:CALAG_RS02175
uniprot id: L0A8L7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1056495:CALAG RS00105
gene id: 1056495:CALAG_RS00105
uniprot id: L0A7H0
names: Cofactor
messages: Binds 1 copper ion per subunit.

1056495:CALAG RS05515
gene id: 1056495:CALAG_RS05515
uniprot id: L0ACI0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1056495:CALAG RS05070
gene id: 1056495:CALAG_RS05070
uniprot id: L0AA33
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1056495:CALAG RS01945
gene id: 1056495:CALAG_RS01945
uniprot id: L0A9S4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1056495:CALAG RS05810
gene id: 1056495:CALAG_RS05810
uniprot id: L0ABV0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

1056495:CALAG RS02480
gene id: 1056495:CALAG_RS02480
uniprot id: L0AB45
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1056495:CALAG RS01900
gene id: 1056495:CALAG_RS01900
uniprot id: L0AAN2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

1056495:CALAG RS06645
gene id: 1056495:CALAG_RS06645
uniprot id: L0ACB5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1056495:CALAG RS04640
gene id: 1056495:CALAG_RS04640
uniprot id: L0AC32
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

1056495:CALAG RS02895
gene id: 1056495:CALAG_RS02895
uniprot id: L0AA97
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

1056495:CALAG RS02080
gene id: 1056495:CALAG_RS02080
uniprot id: L0A9U6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

1056495:CALAG RS07240
gene id: 1056495:CALAG_RS07240
uniprot id: L0ADI1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

1056495:CALAG RS02300
gene id: 1056495:CALAG_RS02300
uniprot id: L0A8R5
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1056495:CALAG RS04990
gene id: 1056495:CALAG_RS04990
uniprot id: L0AC87
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1056495:CALAG RS05230
gene id: 1056495:CALAG_RS05230
uniprot id: L0ACL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1056495:CALAG RS05685
gene id: 1056495:CALAG_RS05685
uniprot id: L0ACV3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1056495:CALAG RS05990
gene id: 1056495:CALAG_RS05990
uniprot id: L0AAK0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1056495:CALAG RS01175
gene id: 1056495:CALAG_RS01175
uniprot id: L0A9C5
names: Similarity
messages: Belongs to the UPF0147 family.