1045858:BINT RS06630
gene id: 1045858:BINT_RS06630
uniprot id: G0EP86
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

1045858:BINT RS13055
gene id: 1045858:BINT_RS13055
uniprot id: G0EPI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

1045858:BINT RS04305
gene id: 1045858:BINT_RS04305
uniprot id: G0ELB4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1045858:BINT RS09930
gene id: 1045858:BINT_RS09930
uniprot id: G0EKN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

1045858:BINT RS00215
gene id: 1045858:BINT_RS00215
uniprot id: G0EP06
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10335
gene id: 1045858:BINT_RS10335
uniprot id: G0EL53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1045858:BINT RS01430
gene id: 1045858:BINT_RS01430
uniprot id: G0EHW4
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS12740
gene id: 1045858:BINT_RS12740
uniprot id: G0ENV9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1045858:BINT RS11870
gene id: 1045858:BINT_RS11870
uniprot id: G0EMX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

1045858:BINT RS02560
gene id: 1045858:BINT_RS02560
uniprot id: G0EJF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

1045858:BINT RS01350
gene id: 1045858:BINT_RS01350
uniprot id: G0EHU8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1045858:BINT RS09335
gene id: 1045858:BINT_RS09335
uniprot id: G0EK39
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1045858:BINT RS05770
gene id: 1045858:BINT_RS05770
uniprot id: G0EN20
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1045858:BINT RS01575
gene id: 1045858:BINT_RS01575
uniprot id: G0EHZ2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1045858:BINT RS08140
gene id: 1045858:BINT_RS08140
uniprot id: G0EIR5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1045858:BINT RS08215
gene id: 1045858:BINT_RS08215
uniprot id: G0EIT2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1045858:BINT RS11615
gene id: 1045858:BINT_RS11615
uniprot id: G0EMS3
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS13885
gene id: 1045858:BINT_RS13885
uniprot id: G0EQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1045858:BINT RS04930
gene id: 1045858:BINT_RS04930
uniprot id: G0EM45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1045858:BINT RS08245
gene id: 1045858:BINT_RS08245
uniprot id: G0EIT8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1045858:BINT RS10185
gene id: 1045858:BINT_RS10185
uniprot id: G0EL23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

1045858:BINT RS01885
gene id: 1045858:BINT_RS01885
uniprot id: G0EIL0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1045858:BINT RS08490
gene id: 1045858:BINT_RS08490
uniprot id: G0EJ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1045858:BINT RS04315
gene id: 1045858:BINT_RS04315
uniprot id: G0ELB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1045858:BINT RS06175
gene id: 1045858:BINT_RS06175
uniprot id: G0ENI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

1045858:BINT RS03510
gene id: 1045858:BINT_RS03510
uniprot id: G0EKE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1045858:BINT RS12960
gene id: 1045858:BINT_RS12960
uniprot id: G0EPF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1045858:BINT RS10665
gene id: 1045858:BINT_RS10665
uniprot id: G0ELJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS02155
gene id: 1045858:BINT_RS02155
uniprot id: G0EIZ3
names: Similarity
messages: Belongs to the MotB family.

1045858:BINT RS12450
gene id: 1045858:BINT_RS12450
uniprot id: G0ENQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1045858:BINT RS00225
gene id: 1045858:BINT_RS00225
uniprot id: G0EP08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1045858:BINT RS02050
gene id: 1045858:BINT_RS02050
uniprot id: G0EIX2
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS08310
gene id: 1045858:BINT_RS08310
uniprot id: G0EIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1045858:BINT RS05900
gene id: 1045858:BINT_RS05900
uniprot id: G0EN48
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS12105
gene id: 1045858:BINT_RS12105
uniprot id: G0ENA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

1045858:BINT RS03400
gene id: 1045858:BINT_RS03400
uniprot id: G0EKC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1045858:BINT RS09100
gene id: 1045858:BINT_RS09100
uniprot id: G0EJR1
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10790
gene id: 1045858:BINT_RS10790
uniprot id: G0ELU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1045858:BINT RS09920
gene id: 1045858:BINT_RS09920
uniprot id: G0EKN7
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS07945
gene id: 1045858:BINT_RS07945
uniprot id: G0EI69
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1045858:BINT RS11855
gene id: 1045858:BINT_RS11855
uniprot id: G0EMX0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1045858:BINT RS13760
gene id: 1045858:BINT_RS13760
uniprot id: G0EQU3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.

1045858:BINT RS06185
gene id: 1045858:BINT_RS06185
uniprot id: G0ENI6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1045858:BINT RS13950
gene id: 1045858:BINT_RS13950
uniprot id: G0EQY1
names: Similarity
messages: Belongs to the peptidase S41A family.

1045858:BINT RS06135
gene id: 1045858:BINT_RS06135
uniprot id: G0ENH5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1045858:BINT RS08420
gene id: 1045858:BINT_RS08420
uniprot id: G0EJ51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1045858:BINT RS12535
gene id: 1045858:BINT_RS12535
uniprot id: G0ENR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1045858:BINT RS01985
gene id: 1045858:BINT_RS01985
uniprot id: G0EIN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1045858:BINT RS11370
gene id: 1045858:BINT_RS11370
uniprot id: G0EME2
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS04595
gene id: 1045858:BINT_RS04595
uniprot id: G0ELP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1045858:BINT RS09130
gene id: 1045858:BINT_RS09130
uniprot id: G0EJR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1045858:BINT RS06855
gene id: 1045858:BINT_RS06855
uniprot id: G0EPU2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1045858:BINT RS10895
gene id: 1045858:BINT_RS10895
uniprot id: G0ELX1
names: Similarity
messages: Belongs to the peptidase S33 family.

1045858:BINT RS05310
gene id: 1045858:BINT_RS05310
uniprot id: G0EMK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Periplasm
messages: Periplasmic flagellum
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.

1045858:BINT RS13770
gene id: 1045858:BINT_RS13770
uniprot id: G0EQU5
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1045858:BINT RS10370
gene id: 1045858:BINT_RS10370
uniprot id: G0ELE0
names: Similarity
messages: Belongs to the ParB family.

1045858:BINT RS02980
gene id: 1045858:BINT_RS02980
uniprot id: G0EJW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

1045858:BINT RS03290
gene id: 1045858:BINT_RS03290
uniprot id: G0EKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1045858:BINT RS09850
gene id: 1045858:BINT_RS09850
uniprot id: G0EKM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1045858:BINT RS06285
gene id: 1045858:BINT_RS06285
uniprot id: G0ENK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemerythrin family.
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1045858:BINT RS02480
gene id: 1045858:BINT_RS02480
uniprot id: G0EJD5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS04995
gene id: 1045858:BINT_RS04995
uniprot id: G0EM58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1045858:BINT RS00830
gene id: 1045858:BINT_RS00830
uniprot id: G0EQA0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1045858:BINT RS12990
gene id: 1045858:BINT_RS12990
uniprot id: G0EPG5
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS09965
gene id: 1045858:BINT_RS09965
uniprot id: G0EKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1045858:BINT RS07390
gene id: 1045858:BINT_RS07390
uniprot id: G0EQL3
names: Similarity
messages: Belongs to the glutamine synthetase family.

1045858:BINT RS05385
gene id: 1045858:BINT_RS05385
uniprot id: G0EML5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS06225
gene id: 1045858:BINT_RS06225
uniprot id: G0ENJ6
names: Similarity
messages: Belongs to the citrate synthase family.

1045858:BINT RS03860
gene id: 1045858:BINT_RS03860
uniprot id: G0EKV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

1045858:BINT RS05745
gene id: 1045858:BINT_RS05745
uniprot id: G0EN15
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1045858:BINT RS11580
gene id: 1045858:BINT_RS11580
uniprot id: G0EMR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1045858:BINT RS12010
gene id: 1045858:BINT_RS12010
uniprot id: G0EN86
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1045858:BINT RS07265
gene id: 1045858:BINT_RS07265
uniprot id: G0EQI8
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS12100
gene id: 1045858:BINT_RS12100
uniprot id: G0ENA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1045858:BINT RS02130
gene id: 1045858:BINT_RS02130
uniprot id: G0EIY8
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1045858:BINT RS06980
gene id: 1045858:BINT_RS06980
uniprot id: G0EPW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS12570
gene id: 1045858:BINT_RS12570
uniprot id: G0ENS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1045858:BINT RS02775
gene id: 1045858:BINT_RS02775
uniprot id: G0EJI9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS14265
gene id: 1045858:BINT_RS14265
uniprot id: G0EID0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1045858:BINT RS13325
gene id: 1045858:BINT_RS13325
uniprot id: G0EQ45
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS08980
gene id: 1045858:BINT_RS08980
uniprot id: G0EJN7
names: Similarity
messages: Belongs to the FGGY kinase family.

1045858:BINT RS04510
gene id: 1045858:BINT_RS04510
uniprot id: G0ELN1
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1045858:BINT RS12980
gene id: 1045858:BINT_RS12980
uniprot id: G0EPG3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1045858:BINT RS04680
gene id: 1045858:BINT_RS04680
uniprot id: G0ELR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1045858:BINT RS05305
gene id: 1045858:BINT_RS05305
uniprot id: G0EMJ9
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS08795
gene id: 1045858:BINT_RS08795
uniprot id: G0EJK1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1045858:BINT RS01280
gene id: 1045858:BINT_RS01280
uniprot id: G0EHT4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS07075
gene id: 1045858:BINT_RS07075
uniprot id: G0EPZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1045858:BINT RS04900
gene id: 1045858:BINT_RS04900
uniprot id: G0EM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS03575
gene id: 1045858:BINT_RS03575
uniprot id: G0EKG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1045858:BINT RS00895
gene id: 1045858:BINT_RS00895
uniprot id: G0EQB4
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS05315
gene id: 1045858:BINT_RS05315
uniprot id: G0EMK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS08465
gene id: 1045858:BINT_RS08465
uniprot id: G0EJ60
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1045858:BINT RS11290
gene id: 1045858:BINT_RS11290
uniprot id: G0EMC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS13845
gene id: 1045858:BINT_RS13845
uniprot id: G0EQW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1045858:BINT RS09125
gene id: 1045858:BINT_RS09125
uniprot id: G0EJR6
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10060
gene id: 1045858:BINT_RS10060
uniprot id: G0EKZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1045858:BINT RS13235
gene id: 1045858:BINT_RS13235
uniprot id: G0EQ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

1045858:BINT RS11325
gene id: 1045858:BINT_RS11325
uniprot id: G0EMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS00200
gene id: 1045858:BINT_RS00200
uniprot id: G0EP03
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1045858:BINT RS09670
gene id: 1045858:BINT_RS09670
uniprot id: G0EKI6
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1045858:BINT RS06470
gene id: 1045858:BINT_RS06470
uniprot id: G0EP54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1045858:BINT RS12060
gene id: 1045858:BINT_RS12060
uniprot id: G0EN96
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

1045858:BINT RS07710
gene id: 1045858:BINT_RS07710
uniprot id: G0EI24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1045858:BINT RS08910
gene id: 1045858:BINT_RS08910
uniprot id: G0EJM3
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1045858:BINT RS00580
gene id: 1045858:BINT_RS00580
uniprot id: G0EPP3
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS03025
gene id: 1045858:BINT_RS03025
uniprot id: G0EJX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1045858:BINT RS01345
gene id: 1045858:BINT_RS01345
uniprot id: G0EHU7
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1045858:BINT RS03300
gene id: 1045858:BINT_RS03300
uniprot id: G0EKA7
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1045858:BINT RS05415
gene id: 1045858:BINT_RS05415
uniprot id: G0EMM1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1045858:BINT RS11955
gene id: 1045858:BINT_RS11955
uniprot id: G0EN74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS03985
gene id: 1045858:BINT_RS03985
uniprot id: G0EKX3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1045858:BINT RS09290
gene id: 1045858:BINT_RS09290
uniprot id: G0EK30
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1045858:BINT RS08275
gene id: 1045858:BINT_RS08275
uniprot id: G0EIU4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS04540
gene id: 1045858:BINT_RS04540
uniprot id: G0ELN7
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1045858:BINT RS05775
gene id: 1045858:BINT_RS05775
uniprot id: G0EN21
names: Similarity
messages: Belongs to the UPF0234 family.

1045858:BINT RS09905
gene id: 1045858:BINT_RS09905
uniprot id: G0EKN4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1045858:BINT RS11590
gene id: 1045858:BINT_RS11590
uniprot id: G0EMR9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1045858:BINT RS02655
gene id: 1045858:BINT_RS02655
uniprot id: G0EJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1045858:BINT RS13005
gene id: 1045858:BINT_RS13005
uniprot id: G0EPG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1045858:BINT RS04755
gene id: 1045858:BINT_RS04755
uniprot id: G0ELT1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1045858:BINT RS12455
gene id: 1045858:BINT_RS12455
uniprot id: G0ENQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1045858:BINT RS02500
gene id: 1045858:BINT_RS02500
uniprot id: G0EJD9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1045858:BINT RS13420
gene id: 1045858:BINT_RS13420
uniprot id: G0EQ64
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1045858:BINT RS00700
gene id: 1045858:BINT_RS00700
uniprot id: G0EPR6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS07380
gene id: 1045858:BINT_RS07380
uniprot id: G0EQL1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1045858:BINT RS12970
gene id: 1045858:BINT_RS12970
uniprot id: G0EPG0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1045858:BINT RS12460
gene id: 1045858:BINT_RS12460
uniprot id: G0ENQ4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1045858:BINT RS04075
gene id: 1045858:BINT_RS04075
uniprot id: G0EL70
names: Function
names: Similarity
messages: Belongs to the chloramphenicol acetyltransferase family.
messages: This enzyme is an effector of chloramphenicol resistance in bacteria.

1045858:BINT RS09915
gene id: 1045858:BINT_RS09915
uniprot id: G0EKN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1045858:BINT RS06680
gene id: 1045858:BINT_RS06680
uniprot id: G0EP97
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1045858:BINT RS11180
gene id: 1045858:BINT_RS11180
uniprot id: G0EMA4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1045858:BINT RS01930
gene id: 1045858:BINT_RS01930
uniprot id: G0EIL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum

1045858:BINT RS01540
gene id: 1045858:BINT_RS01540
uniprot id: G0EHY5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

1045858:BINT RS01085
gene id: 1045858:BINT_RS01085
uniprot id: G0EQF3
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1045858:BINT RS04000
gene id: 1045858:BINT_RS04000
uniprot id: G0EKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1045858:BINT RS03035
gene id: 1045858:BINT_RS03035
uniprot id: G0EJX2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1045858:BINT RS05455
gene id: 1045858:BINT_RS05455
uniprot id: G0EMM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

1045858:BINT RS13195
gene id: 1045858:BINT_RS13195
uniprot id: G0EQ19
names: Function
names: Similarity
messages: Belongs to the vsr family.
messages: May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.

1045858:BINT RS01165
gene id: 1045858:BINT_RS01165
uniprot id: G0EQG9
names: Similarity
messages: Belongs to the RecJ family.

1045858:BINT RS00850
gene id: 1045858:BINT_RS00850
uniprot id: G0EQA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1045858:BINT RS02335
gene id: 1045858:BINT_RS02335
uniprot id: G0EJ27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1045858:BINT RS13245
gene id: 1045858:BINT_RS13245
uniprot id: G0EQ29
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1045858:BINT RS01370
gene id: 1045858:BINT_RS01370
uniprot id: G0EHV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS11225
gene id: 1045858:BINT_RS11225
uniprot id: G0EMB3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1045858:BINT RS00135
gene id: 1045858:BINT_RS00135
uniprot id: G0ENZ0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1045858:BINT RS11705
gene id: 1045858:BINT_RS11705
uniprot id: G0EMU1
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1045858:BINT RS04830
gene id: 1045858:BINT_RS04830
uniprot id: G0EM27
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1045858:BINT RS05620
gene id: 1045858:BINT_RS05620
uniprot id: G0EMR1
names: Similarity
messages: Belongs to the peptidase M24B family.

1045858:BINT RS06280
gene id: 1045858:BINT_RS06280
uniprot id: G0ENK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemerythrin family.
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1045858:BINT RS04470
gene id: 1045858:BINT_RS04470
uniprot id: G0ELM6
names: Similarity
messages: Belongs to the pyruvate kinase family.

1045858:BINT RS12365
gene id: 1045858:BINT_RS12365
uniprot id: G0ENN6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1045858:BINT RS14220
gene id: 1045858:BINT_RS14220
uniprot id: G0EIC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1045858:BINT RS11040
gene id: 1045858:BINT_RS11040
uniprot id: G0ELZ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1045858:BINT RS02815
gene id: 1045858:BINT_RS02815
uniprot id: G0EJS7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS08385
gene id: 1045858:BINT_RS08385
uniprot id: G0EJ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS12360
gene id: 1045858:BINT_RS12360
uniprot id: G0ENN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1045858:BINT RS09835
gene id: 1045858:BINT_RS09835
uniprot id: G0EKM0
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS09275
gene id: 1045858:BINT_RS09275
uniprot id: G0EK27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1045858:BINT RS06170
gene id: 1045858:BINT_RS06170
uniprot id: G0ENI3
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10240
gene id: 1045858:BINT_RS10240
uniprot id: G0EL35
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1045858:BINT RS02165
gene id: 1045858:BINT_RS02165
uniprot id: G0EIZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1045858:BINT RS12250
gene id: 1045858:BINT_RS12250
uniprot id: G0END3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1045858:BINT RS01660
gene id: 1045858:BINT_RS01660
uniprot id: G0EIG5
names: Similarity
messages: Belongs to the UPF0164 family.

1045858:BINT RS01825
gene id: 1045858:BINT_RS01825
uniprot id: G0EIJ8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1045858:BINT RS01845
gene id: 1045858:BINT_RS01845
uniprot id: G0EIK2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1045858:BINT RS02760
gene id: 1045858:BINT_RS02760
uniprot id: G0EJI5
names: Similarity
messages: Belongs to the GARS family.

1045858:BINT RS03465
gene id: 1045858:BINT_RS03465
uniprot id: G0EKE0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1045858:BINT RS13910
gene id: 1045858:BINT_RS13910
uniprot id: G0EQX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1045858:BINT RS08540
gene id: 1045858:BINT_RS08540
uniprot id: G0EJ74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS00995
gene id: 1045858:BINT_RS00995
uniprot id: G0EQD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1045858:BINT RS12645
gene id: 1045858:BINT_RS12645
uniprot id: G0ENU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS10190
gene id: 1045858:BINT_RS10190
uniprot id: G0EL24
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS03615
gene id: 1045858:BINT_RS03615
uniprot id: G0EKP9
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1045858:BINT RS05100
gene id: 1045858:BINT_RS05100
uniprot id: G0EM77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

1045858:BINT RS09285
gene id: 1045858:BINT_RS09285
uniprot id: G0EK29
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1045858:BINT RS10535
gene id: 1045858:BINT_RS10535
uniprot id: G0ELH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

1045858:BINT RS08415
gene id: 1045858:BINT_RS08415
uniprot id: G0EJ50
names: Similarity
messages: Belongs to the fabD family.

1045858:BINT RS07905
gene id: 1045858:BINT_RS07905
uniprot id: G0EI61
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1045858:BINT RS05805
gene id: 1045858:BINT_RS05805
uniprot id: G0EN27
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

1045858:BINT RS02175
gene id: 1045858:BINT_RS02175
uniprot id: G0EIZ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS09735
gene id: 1045858:BINT_RS09735
uniprot id: G0EKJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS11770
gene id: 1045858:BINT_RS11770
uniprot id: G0EMV4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1045858:BINT RS06710
gene id: 1045858:BINT_RS06710
uniprot id: G0EPA3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1045858:BINT RS03125
gene id: 1045858:BINT_RS03125
uniprot id: G0EJZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1045858:BINT RS12550
gene id: 1045858:BINT_RS12550
uniprot id: G0ENS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1045858:BINT RS08280
gene id: 1045858:BINT_RS08280
uniprot id: G0EIU5
names: Similarity
messages: Belongs to the peptidase M24B family.

1045858:BINT RS05755
gene id: 1045858:BINT_RS05755
uniprot id: G0EN17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

1045858:BINT RS01470
gene id: 1045858:BINT_RS01470
uniprot id: G0EHX2
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1045858:BINT RS11045
gene id: 1045858:BINT_RS11045
uniprot id: G0EM00
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1045858:BINT RS12710
gene id: 1045858:BINT_RS12710
uniprot id: G0ENV3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1045858:BINT RS03555
gene id: 1045858:BINT_RS03555
uniprot id: G0EKF8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1045858:BINT RS13485
gene id: 1045858:BINT_RS13485
uniprot id: G0EQ76
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS07050
gene id: 1045858:BINT_RS07050
uniprot id: G0EPY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1045858:BINT RS11710
gene id: 1045858:BINT_RS11710
uniprot id: G0EMU2
names: Similarity
messages: Belongs to the Fur family.

1045858:BINT RS12095
gene id: 1045858:BINT_RS12095
uniprot id: G0ENA3
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1045858:BINT RS05170
gene id: 1045858:BINT_RS05170
uniprot id: G0EM91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

1045858:BINT RS13445
gene id: 1045858:BINT_RS13445
uniprot id: G0EQ68
names: Similarity
messages: Belongs to the peptidase C56 family.

1045858:BINT RS01595
gene id: 1045858:BINT_RS01595
uniprot id: G0EIF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1045858:BINT RS11875
gene id: 1045858:BINT_RS11875
uniprot id: G0EMX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1045858:BINT RS10695
gene id: 1045858:BINT_RS10695
uniprot id: G0ELK3
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS06800
gene id: 1045858:BINT_RS06800
uniprot id: G0EPC1
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10430
gene id: 1045858:BINT_RS10430
uniprot id: G0ELF2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1045858:BINT RS09410
gene id: 1045858:BINT_RS09410
uniprot id: G0EK54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1045858:BINT RS07825
gene id: 1045858:BINT_RS07825
uniprot id: G0EI47
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10255
gene id: 1045858:BINT_RS10255
uniprot id: G0EL38
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS01860
gene id: 1045858:BINT_RS01860
uniprot id: G0EIK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1045858:BINT RS10800
gene id: 1045858:BINT_RS10800
uniprot id: G0ELV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

1045858:BINT RS05905
gene id: 1045858:BINT_RS05905
uniprot id: G0EN49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1045858:BINT RS10760
gene id: 1045858:BINT_RS10760
uniprot id: G0ELL4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1045858:BINT RS13730
gene id: 1045858:BINT_RS13730
uniprot id: G0EQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1045858:BINT RS06190
gene id: 1045858:BINT_RS06190
uniprot id: G0ENI7
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1045858:BINT RS02505
gene id: 1045858:BINT_RS02505
uniprot id: G0EJE0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1045858:BINT RS13120
gene id: 1045858:BINT_RS13120
uniprot id: G0EPJ2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1045858:BINT RS02330
gene id: 1045858:BINT_RS02330
uniprot id: G0EJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1045858:BINT RS04045
gene id: 1045858:BINT_RS04045
uniprot id: G0EL65
names: Similarity
messages: Belongs to the DprA/Smf family.

1045858:BINT RS03350
gene id: 1045858:BINT_RS03350
uniprot id: G0EKB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

1045858:BINT RS06010
gene id: 1045858:BINT_RS06010
uniprot id: G0EN70
names: Similarity
messages: Belongs to the TlyA family.

1045858:BINT RS06785
gene id: 1045858:BINT_RS06785
uniprot id: G0EPB8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1045858:BINT RS08815
gene id: 1045858:BINT_RS08815
uniprot id: G0EJK5
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1045858:BINT RS04210
gene id: 1045858:BINT_RS04210
uniprot id: G0EL97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1045858:BINT RS10835
gene id: 1045858:BINT_RS10835
uniprot id: G0ELV7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1045858:BINT RS13305
gene id: 1045858:BINT_RS13305
uniprot id: G0EQ41
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

1045858:BINT RS02000
gene id: 1045858:BINT_RS02000
uniprot id: G0EIW4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1045858:BINT RS09545
gene id: 1045858:BINT_RS09545
uniprot id: G0EK81
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

1045858:BINT RS09690
gene id: 1045858:BINT_RS09690
uniprot id: G0EKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS10035
gene id: 1045858:BINT_RS10035
uniprot id: G0EKZ0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1045858:BINT RS08670
gene id: 1045858:BINT_RS08670
uniprot id: G0EJ97
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS12375
gene id: 1045858:BINT_RS12375
uniprot id: G0ENN8
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1045858:BINT RS06445
gene id: 1045858:BINT_RS06445
uniprot id: G0EP49
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1045858:BINT RS07070
gene id: 1045858:BINT_RS07070
uniprot id: G0EPY9
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1045858:BINT RS06690
gene id: 1045858:BINT_RS06690
uniprot id: G0EP99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1045858:BINT RS12555
gene id: 1045858:BINT_RS12555
uniprot id: G0ENS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1045858:BINT RS05075
gene id: 1045858:BINT_RS05075
uniprot id: G0EM72
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1045858:BINT RS06110
gene id: 1045858:BINT_RS06110
uniprot id: G0ENH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1045858:BINT RS14190
gene id: 1045858:BINT_RS14190
uniprot id: G0EIB5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1045858:BINT RS03940
gene id: 1045858:BINT_RS03940
uniprot id: G0EKW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS09790
gene id: 1045858:BINT_RS09790
uniprot id: G0EKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

1045858:BINT RS12525
gene id: 1045858:BINT_RS12525
uniprot id: G0ENR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1045858:BINT RS04460
gene id: 1045858:BINT_RS04460
uniprot id: G0ELM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1045858:BINT RS05795
gene id: 1045858:BINT_RS05795
uniprot id: G0EN25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1045858:BINT RS10220
gene id: 1045858:BINT_RS10220
uniprot id: G0EL31
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1045858:BINT RS04620
gene id: 1045858:BINT_RS04620
uniprot id: G0ELQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

1045858:BINT RS01900
gene id: 1045858:BINT_RS01900
uniprot id: G0EIL3
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1045858:BINT RS08325
gene id: 1045858:BINT_RS08325
uniprot id: G0EIV4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS05220
gene id: 1045858:BINT_RS05220
uniprot id: G0EMA1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1045858:BINT RS10260
gene id: 1045858:BINT_RS10260
uniprot id: G0EL39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1045858:BINT RS05200
gene id: 1045858:BINT_RS05200
uniprot id: G0EM97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1045858:BINT RS02945
gene id: 1045858:BINT_RS02945
uniprot id: G0EJV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1045858:BINT RS05490
gene id: 1045858:BINT_RS05490
uniprot id: G0EMN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1045858:BINT RS09610
gene id: 1045858:BINT_RS09610
uniprot id: G0EKH4
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS04845
gene id: 1045858:BINT_RS04845
uniprot id: G0EM30
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS13530
gene id: 1045858:BINT_RS13530
uniprot id: G0EQ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1045858:BINT RS12240
gene id: 1045858:BINT_RS12240
uniprot id: G0END1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1045858:BINT RS09795
gene id: 1045858:BINT_RS09795
uniprot id: G0EKL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1045858:BINT RS06050
gene id: 1045858:BINT_RS06050
uniprot id: G0ENF8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1045858:BINT RS10230
gene id: 1045858:BINT_RS10230
uniprot id: G0EL33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1045858:BINT RS10715
gene id: 1045858:BINT_RS10715
uniprot id: G0ELK7
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1045858:BINT RS03670
gene id: 1045858:BINT_RS03670
uniprot id: G0EKR0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1045858:BINT RS08365
gene id: 1045858:BINT_RS08365
uniprot id: G0EJ40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1045858:BINT RS12410
gene id: 1045858:BINT_RS12410
uniprot id: G0ENP5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS05015
gene id: 1045858:BINT_RS05015
uniprot id: G0EM62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1045858:BINT RS09910
gene id: 1045858:BINT_RS09910
uniprot id: G0EKN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1045858:BINT RS08695
gene id: 1045858:BINT_RS08695
uniprot id: G0EJA2
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1045858:BINT RS10330
gene id: 1045858:BINT_RS10330
uniprot id: G0EL52
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS02360
gene id: 1045858:BINT_RS02360
uniprot id: G0EJ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1045858:BINT RS03840
gene id: 1045858:BINT_RS03840
uniprot id: G0EKU6
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10325
gene id: 1045858:BINT_RS10325
uniprot id: G0EL51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1045858:BINT RS01465
gene id: 1045858:BINT_RS01465
uniprot id: G0EHX1
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1045858:BINT RS07145
gene id: 1045858:BINT_RS07145
uniprot id: G0EQ04
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1045858:BINT RS10690
gene id: 1045858:BINT_RS10690
uniprot id: G0ELK2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1045858:BINT RS00220
gene id: 1045858:BINT_RS00220
uniprot id: G0EP07
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS01905
gene id: 1045858:BINT_RS01905
uniprot id: G0EIL4
names: Similarity
messages: Belongs to the CdaR family.

1045858:BINT RS10455
gene id: 1045858:BINT_RS10455
uniprot id: G0ELF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1045858:BINT RS08840
gene id: 1045858:BINT_RS08840
uniprot id: G0EJL0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1045858:BINT RS00235
gene id: 1045858:BINT_RS00235
uniprot id: G0EP10
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1045858:BINT RS13020
gene id: 1045858:BINT_RS13020
uniprot id: G0EPH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1045858:BINT RS00920
gene id: 1045858:BINT_RS00920
uniprot id: G0EQB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

1045858:BINT RS10515
gene id: 1045858:BINT_RS10515
uniprot id: G0ELG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS06220
gene id: 1045858:BINT_RS06220
uniprot id: G0ENJ5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1045858:BINT RS04115
gene id: 1045858:BINT_RS04115
uniprot id: G0EL78
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS06915
gene id: 1045858:BINT_RS06915
uniprot id: G0EPV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1045858:BINT RS13810
gene id: 1045858:BINT_RS13810
uniprot id: G0EQV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1045858:BINT RS13070
gene id: 1045858:BINT_RS13070
uniprot id: G0EPI3
names: Similarity
messages: Belongs to the peptidase M16 family.

1045858:BINT RS08505
gene id: 1045858:BINT_RS08505
uniprot id: G0EJ67
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1045858:BINT RS03855
gene id: 1045858:BINT_RS03855
uniprot id: G0EKU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

1045858:BINT RS13065
gene id: 1045858:BINT_RS13065
uniprot id: G0EPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm

1045858:BINT RS07000
gene id: 1045858:BINT_RS07000
uniprot id: G0EPX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS12470
gene id: 1045858:BINT_RS12470
uniprot id: G0ENQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1045858:BINT RS01645
gene id: 1045858:BINT_RS01645
uniprot id: G0EIG2
names: Similarity
messages: Belongs to the peptidase S66 family.

1045858:BINT RS14180
gene id: 1045858:BINT_RS14180
uniprot id: G0EIB3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1045858:BINT RS12345
gene id: 1045858:BINT_RS12345
uniprot id: G0ENF2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS09385
gene id: 1045858:BINT_RS09385
uniprot id: G0EK49
names: Similarity
messages: Belongs to the sigma-54 factor family.

1045858:BINT RS02190
gene id: 1045858:BINT_RS02190
uniprot id: G0EJ00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1045858:BINT RS07940
gene id: 1045858:BINT_RS07940
uniprot id: G0EI68
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1045858:BINT RS11925
gene id: 1045858:BINT_RS11925
uniprot id: G0EMY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1045858:BINT RS02280
gene id: 1045858:BINT_RS02280
uniprot id: G0EJ16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1045858:BINT RS02075
gene id: 1045858:BINT_RS02075
uniprot id: G0EIX7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1045858:BINT RS13640
gene id: 1045858:BINT_RS13640
uniprot id: G0EQR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1045858:BINT RS11550
gene id: 1045858:BINT_RS11550
uniprot id: G0EMI1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1045858:BINT RS04775
gene id: 1045858:BINT_RS04775
uniprot id: G0ELT5
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS02895
gene id: 1045858:BINT_RS02895
uniprot id: G0EJU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS11015
gene id: 1045858:BINT_RS11015
uniprot id: G0ELZ4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

1045858:BINT RS13590
gene id: 1045858:BINT_RS13590
uniprot id: G0EQR0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

1045858:BINT RS03550
gene id: 1045858:BINT_RS03550
uniprot id: G0EKF7
names: Similarity
names: Subunit
messages: Belongs to the methylthioribose kinase family.
messages: Homodimer.

1045858:BINT RS06835
gene id: 1045858:BINT_RS06835
uniprot id: G0EPT8
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1045858:BINT RS13210
gene id: 1045858:BINT_RS13210
uniprot id: G0EQ22
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1045858:BINT RS10480
gene id: 1045858:BINT_RS10480
uniprot id: G0ELG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1045858:BINT RS06620
gene id: 1045858:BINT_RS06620
uniprot id: G0EP83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1045858:BINT RS13465
gene id: 1045858:BINT_RS13465
uniprot id: G0EQ72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1045858:BINT RS10425
gene id: 1045858:BINT_RS10425
uniprot id: G0ELF1
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS07515
gene id: 1045858:BINT_RS07515
uniprot id: G0EQP3
names: Similarity
messages: Belongs to the peptidase S14 family.

1045858:BINT RS10120
gene id: 1045858:BINT_RS10120
uniprot id: G0EL08
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1045858:BINT RS08110
gene id: 1045858:BINT_RS08110
uniprot id: G0EIQ9
names: Similarity
messages: Belongs to the UPF0047 family.

1045858:BINT RS08330
gene id: 1045858:BINT_RS08330
uniprot id: G0EIV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1045858:BINT RS05510
gene id: 1045858:BINT_RS05510
uniprot id: G0EMP0
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1045858:BINT RS11605
gene id: 1045858:BINT_RS11605
uniprot id: G0EMS1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1045858:BINT RS06430
gene id: 1045858:BINT_RS06430
uniprot id: G0EP46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1045858:BINT RS09785
gene id: 1045858:BINT_RS09785
uniprot id: G0EKK9
names: Function
names: Subcellular Location Annotation
messages: Component of the core of the flagella.
messages: Periplasmic flagellum

1045858:BINT RS05460
gene id: 1045858:BINT_RS05460
uniprot id: G0EMN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1045858:BINT RS00210
gene id: 1045858:BINT_RS00210
uniprot id: G0EP05
names: Subcellular Location Annotation
messages: Cytoplasm

1045858:BINT RS09085
gene id: 1045858:BINT_RS09085
uniprot id: G0EJQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1045858:BINT RS02185
gene id: 1045858:BINT_RS02185
uniprot id: G0EIZ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1045858:BINT RS11250
gene id: 1045858:BINT_RS11250
uniprot id: G0EMB8
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1045858:BINT RS03760
gene id: 1045858:BINT_RS03760
uniprot id: G0EKS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS12070
gene id: 1045858:BINT_RS12070
uniprot id: G0EN98
names: Function
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family. Butyryl-CoA CoA-transferase subfamily.
messages: Coenzyme A-transferase that converts butyryl-CoA to butyrate.

1045858:BINT RS00855
gene id: 1045858:BINT_RS00855
uniprot id: G0EQA5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS02300
gene id: 1045858:BINT_RS02300
uniprot id: G0EJ20
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1045858:BINT RS01235
gene id: 1045858:BINT_RS01235
uniprot id: G0EHS5
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1045858:BINT RS02310
gene id: 1045858:BINT_RS02310
uniprot id: G0EJ22
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1045858:BINT RS12380
gene id: 1045858:BINT_RS12380
uniprot id: G0ENN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1045858:BINT RS03185
gene id: 1045858:BINT_RS03185
uniprot id: G0EK03
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1045858:BINT RS08750
gene id: 1045858:BINT_RS08750
uniprot id: G0EJB3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1045858:BINT RS08745
gene id: 1045858:BINT_RS08745
uniprot id: G0EJB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1045858:BINT RS11495
gene id: 1045858:BINT_RS11495
uniprot id: G0EMG8
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1045858:BINT RS02785
gene id: 1045858:BINT_RS02785
uniprot id: G0EJJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

1045858:BINT RS03395
gene id: 1045858:BINT_RS03395
uniprot id: G0EKC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1045858:BINT RS04800
gene id: 1045858:BINT_RS04800
uniprot id: G0ELU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS05705
gene id: 1045858:BINT_RS05705
uniprot id: G0EN07
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1045858:BINT RS11890
gene id: 1045858:BINT_RS11890
uniprot id: G0EMX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1045858:BINT RS00115
gene id: 1045858:BINT_RS00115
uniprot id: G0ENY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1045858:BINT RS05665
gene id: 1045858:BINT_RS05665
uniprot id: G0EMZ9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1045858:BINT RS09975
gene id: 1045858:BINT_RS09975
uniprot id: G0EKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1045858:BINT RS12775
gene id: 1045858:BINT_RS12775
uniprot id: G0EPC7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1045858:BINT RS12485
gene id: 1045858:BINT_RS12485
uniprot id: G0ENQ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1045858:BINT RS09895
gene id: 1045858:BINT_RS09895
uniprot id: G0EKN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1045858:BINT RS03415
gene id: 1045858:BINT_RS03415
uniprot id: G0EKD0
names: Similarity
messages: Belongs to the UPF0145 family.

1045858:BINT RS02140
gene id: 1045858:BINT_RS02140
uniprot id: G0EIZ0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1045858:BINT RS13220
gene id: 1045858:BINT_RS13220
uniprot id: G0EQ23
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1045858:BINT RS00820
gene id: 1045858:BINT_RS00820
uniprot id: G0EQ98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

1045858:BINT RS06210
gene id: 1045858:BINT_RS06210
uniprot id: G0ENJ2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1045858:BINT RS08430
gene id: 1045858:BINT_RS08430
uniprot id: G0EJ53
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

1045858:BINT RS13275
gene id: 1045858:BINT_RS13275
uniprot id: G0EQ34
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1045858:BINT RS10765
gene id: 1045858:BINT_RS10765
uniprot id: G0ELL5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1045858:BINT RS08095
gene id: 1045858:BINT_RS08095
uniprot id: G0EIQ6
names: Similarity
messages: Belongs to the peptidase U62 family.

1045858:BINT RS05425
gene id: 1045858:BINT_RS05425
uniprot id: G0EMM3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1045858:BINT RS11120
gene id: 1045858:BINT_RS11120
uniprot id: G0EM14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1045858:BINT RS13705
gene id: 1045858:BINT_RS13705
uniprot id: G0EQT2
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

1045858:BINT RS06985
gene id: 1045858:BINT_RS06985
uniprot id: G0EPX0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1045858:BINT RS12870
gene id: 1045858:BINT_RS12870
uniprot id: G0EPE1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1045858:BINT RS07375
gene id: 1045858:BINT_RS07375
uniprot id: G0EQL0
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1045858:BINT RS09340
gene id: 1045858:BINT_RS09340
uniprot id: G0EK40
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1045858:BINT RS04245
gene id: 1045858:BINT_RS04245
uniprot id: G0ELA3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.

1045858:BINT RS05940
gene id: 1045858:BINT_RS05940
uniprot id: G0EN56
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1045858:BINT RS11795
gene id: 1045858:BINT_RS11795
uniprot id: G0EMV9
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1045858:BINT RS12580
gene id: 1045858:BINT_RS12580
uniprot id: G0ENS8
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1045858:BINT RS03015
gene id: 1045858:BINT_RS03015
uniprot id: G0EJW8
names: Subcellular Location Annotation
messages: Periplasmic flagellum

1045858:BINT RS12480
gene id: 1045858:BINT_RS12480
uniprot id: G0ENQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1045858:BINT RS00705
gene id: 1045858:BINT_RS00705
uniprot id: G0EPR7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS03120
gene id: 1045858:BINT_RS03120
uniprot id: G0EJZ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1045858:BINT RS10250
gene id: 1045858:BINT_RS10250
uniprot id: G0EL37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

1045858:BINT RS06505
gene id: 1045858:BINT_RS06505
uniprot id: G0EP61
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1045858:BINT RS09205
gene id: 1045858:BINT_RS09205
uniprot id: G0EK13
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1045858:BINT RS11455
gene id: 1045858:BINT_RS11455
uniprot id: G0EMG0
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1045858:BINT RS04535
gene id: 1045858:BINT_RS04535
uniprot id: G0ELN6
names: Similarity
names: Subunit
messages: Belongs to the methylthioribose kinase family.
messages: Homodimer.

1045858:BINT RS05115
gene id: 1045858:BINT_RS05115
uniprot id: G0EM80
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.

1045858:BINT RS04690
gene id: 1045858:BINT_RS04690
uniprot id: G0ELR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS11545
gene id: 1045858:BINT_RS11545
uniprot id: G0EMI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1045858:BINT RS01880
gene id: 1045858:BINT_RS01880
uniprot id: G0EIK9
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1045858:BINT RS00915
gene id: 1045858:BINT_RS00915
uniprot id: G0EQB8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1045858:BINT RS03875
gene id: 1045858:BINT_RS03875
uniprot id: G0EKV3
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1045858:BINT RS11110
gene id: 1045858:BINT_RS11110
uniprot id: G0EM12
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS06565
gene id: 1045858:BINT_RS06565
uniprot id: G0EP72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1045858:BINT RS05120
gene id: 1045858:BINT_RS05120
uniprot id: G0EM81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.
messages: Homodimer.

1045858:BINT RS03390
gene id: 1045858:BINT_RS03390
uniprot id: G0EKC5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS14080
gene id: 1045858:BINT_RS14080
uniprot id: G0EI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1045858:BINT RS05260
gene id: 1045858:BINT_RS05260
uniprot id: G0EMJ0
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS12720
gene id: 1045858:BINT_RS12720
uniprot id: G0ENV5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1045858:BINT RS06120
gene id: 1045858:BINT_RS06120
uniprot id: G0ENH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS12520
gene id: 1045858:BINT_RS12520
uniprot id: G0ENR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1045858:BINT RS04160
gene id: 1045858:BINT_RS04160
uniprot id: G0EL87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS02370
gene id: 1045858:BINT_RS02370
uniprot id: G0EJ33
names: Similarity
messages: Belongs to the Skp family.

1045858:BINT RS06875
gene id: 1045858:BINT_RS06875
uniprot id: G0EPU6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS11090
gene id: 1045858:BINT_RS11090
uniprot id: G0EM08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1045858:BINT RS01910
gene id: 1045858:BINT_RS01910
uniprot id: G0EIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1045858:BINT RS00805
gene id: 1045858:BINT_RS00805
uniprot id: G0EQ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

1045858:BINT RS10540
gene id: 1045858:BINT_RS10540
uniprot id: G0ELH1
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1045858:BINT RS12500
gene id: 1045858:BINT_RS12500
uniprot id: G0ENR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1045858:BINT RS12390
gene id: 1045858:BINT_RS12390
uniprot id: G0ENP1
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1045858:BINT RS05815
gene id: 1045858:BINT_RS05815
uniprot id: G0EN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS07235
gene id: 1045858:BINT_RS07235
uniprot id: G0EQI2
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1045858:BINT RS10175
gene id: 1045858:BINT_RS10175
uniprot id: G0EL21
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

1045858:BINT RS03990
gene id: 1045858:BINT_RS03990
uniprot id: G0EKX4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1045858:BINT RS09675
gene id: 1045858:BINT_RS09675
uniprot id: G0EKI7
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1045858:BINT RS08450
gene id: 1045858:BINT_RS08450
uniprot id: G0EJ57
names: Similarity
messages: Belongs to the peptidase M29 family.

1045858:BINT RS04515
gene id: 1045858:BINT_RS04515
uniprot id: G0ELN2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1045858:BINT RS04310
gene id: 1045858:BINT_RS04310
uniprot id: G0ELB5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1045858:BINT RS03795
gene id: 1045858:BINT_RS03795
uniprot id: G0EKT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GmhB family.
messages: Cytoplasm

1045858:BINT RS03225
gene id: 1045858:BINT_RS03225
uniprot id: G0EK92
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1045858:BINT RS00145
gene id: 1045858:BINT_RS00145
uniprot id: G0ENZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1045858:BINT RS08675
gene id: 1045858:BINT_RS08675
uniprot id: G0EJ98
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1045858:BINT RS07155
gene id: 1045858:BINT_RS07155
uniprot id: G0EQ06
names: Similarity
messages: Belongs to the TPP enzyme family.

1045858:BINT RS08010
gene id: 1045858:BINT_RS08010
uniprot id: G0EIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1045858:BINT RS12465
gene id: 1045858:BINT_RS12465
uniprot id: G0ENQ5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1045858:BINT RS11565
gene id: 1045858:BINT_RS11565
uniprot id: G0EMR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1045858:BINT RS08615
gene id: 1045858:BINT_RS08615
uniprot id: G0EJ86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1045858:BINT RS05380
gene id: 1045858:BINT_RS05380
uniprot id: G0EML4
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1045858:BINT RS13025
gene id: 1045858:BINT_RS13025
uniprot id: G0EPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1045858:BINT RS09505
gene id: 1045858:BINT_RS09505
uniprot id: G0EK73
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1045858:BINT RS13790
gene id: 1045858:BINT_RS13790
uniprot id: G0EQU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1045858:BINT RS04650
gene id: 1045858:BINT_RS04650
uniprot id: G0ELQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS08820
gene id: 1045858:BINT_RS08820
uniprot id: G0EJK6
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1045858:BINT RS03610
gene id: 1045858:BINT_RS03610
uniprot id: G0EKP8
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1045858:BINT RS14295
gene id: 1045858:BINT_RS14295
uniprot id: G0EID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1045858:BINT RS09170
gene id: 1045858:BINT_RS09170
uniprot id: G0EJS6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1045858:BINT RS11570
gene id: 1045858:BINT_RS11570
uniprot id: G0EMR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1045858:BINT RS00105
gene id: 1045858:BINT_RS00105
uniprot id: G0ENY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS12295
gene id: 1045858:BINT_RS12295
uniprot id: G0ENE2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1045858:BINT RS14120
gene id: 1045858:BINT_RS14120
uniprot id: G0EIA2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1045858:BINT RS10265
gene id: 1045858:BINT_RS10265
uniprot id: G0EL40
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1045858:BINT RS09515
gene id: 1045858:BINT_RS09515
uniprot id: G0EK75
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS07695
gene id: 1045858:BINT_RS07695
uniprot id: G0EI21
names: Similarity
messages: Belongs to the threonine aldolase family.

1045858:BINT RS01800
gene id: 1045858:BINT_RS01800
uniprot id: G0EIJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1045858:BINT RS13015
gene id: 1045858:BINT_RS13015
uniprot id: G0EPH1
names: Similarity
messages: Belongs to the FGGY kinase family.

1045858:BINT RS10180
gene id: 1045858:BINT_RS10180
uniprot id: G0EL22
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS08255
gene id: 1045858:BINT_RS08255
uniprot id: G0EIU0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

1045858:BINT RS09945
gene id: 1045858:BINT_RS09945
uniprot id: G0EKP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1045858:BINT RS03730
gene id: 1045858:BINT_RS03730
uniprot id: G0EKS2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1045858:BINT RS09700
gene id: 1045858:BINT_RS09700
uniprot id: G0EKJ2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1045858:BINT RS01120
gene id: 1045858:BINT_RS01120
uniprot id: G0EQG0
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1045858:BINT RS07990
gene id: 1045858:BINT_RS07990
uniprot id: G0EIN5
names: Subcellular Location Annotation
messages: Bacterial microcompartment

1045858:BINT RS01425
gene id: 1045858:BINT_RS01425
uniprot id: G0EHW3
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS01090
gene id: 1045858:BINT_RS01090
uniprot id: G0EQF4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1045858:BINT RS00175
gene id: 1045858:BINT_RS00175
uniprot id: G0ENZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1045858:BINT RS06685
gene id: 1045858:BINT_RS06685
uniprot id: G0EP98
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1045858:BINT RS02915
gene id: 1045858:BINT_RS02915
uniprot id: G0EJU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1045858:BINT RS14200
gene id: 1045858:BINT_RS14200
uniprot id: G0EIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1045858:BINT RS09255
gene id: 1045858:BINT_RS09255
uniprot id: G0EK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS08535
gene id: 1045858:BINT_RS08535
uniprot id: G0EJ73
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1045858:BINT RS02750
gene id: 1045858:BINT_RS02750
uniprot id: G0EJI3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1045858:BINT RS13515
gene id: 1045858:BINT_RS13515
uniprot id: G0EQ82
names: Similarity
messages: Belongs to the arginase family.

1045858:BINT RS02515
gene id: 1045858:BINT_RS02515
uniprot id: G0EJE2
names: Similarity
messages: Belongs to the peptidase S58 family.

1045858:BINT RS08435
gene id: 1045858:BINT_RS08435
uniprot id: G0EJ54
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS13915
gene id: 1045858:BINT_RS13915
uniprot id: G0EQX4
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10825
gene id: 1045858:BINT_RS10825
uniprot id: G0ELV5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1045858:BINT RS12475
gene id: 1045858:BINT_RS12475
uniprot id: G0ENQ7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1045858:BINT RS08635
gene id: 1045858:BINT_RS08635
uniprot id: G0EJ90
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1045858:BINT RS13865
gene id: 1045858:BINT_RS13865
uniprot id: G0EQW4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1045858:BINT RS10280
gene id: 1045858:BINT_RS10280
uniprot id: G0EL43
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1045858:BINT RS13860
gene id: 1045858:BINT_RS13860
uniprot id: G0EQW3
names: Similarity
messages: Belongs to the hemerythrin family.

1045858:BINT RS09235
gene id: 1045858:BINT_RS09235
uniprot id: G0EK19
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1045858:BINT RS08790
gene id: 1045858:BINT_RS08790
uniprot id: G0EJK0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1045858:BINT RS14075
gene id: 1045858:BINT_RS14075
uniprot id: G0EI93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1045858:BINT RS12885
gene id: 1045858:BINT_RS12885
uniprot id: G0EPE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1045858:BINT RS00230
gene id: 1045858:BINT_RS00230
uniprot id: G0EP09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1045858:BINT RS09665
gene id: 1045858:BINT_RS09665
uniprot id: G0EKI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1045858:BINT RS05750
gene id: 1045858:BINT_RS05750
uniprot id: G0EN16
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1045858:BINT RS06960
gene id: 1045858:BINT_RS06960
uniprot id: G0EPW5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1045858:BINT RS04600
gene id: 1045858:BINT_RS04600
uniprot id: G0ELP8
names: Similarity
messages: Belongs to the DtxR/MntR family.

1045858:BINT RS08250
gene id: 1045858:BINT_RS08250
uniprot id: G0EIT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

1045858:BINT RS09525
gene id: 1045858:BINT_RS09525
uniprot id: G0EK77
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

1045858:BINT RS08115
gene id: 1045858:BINT_RS08115
uniprot id: G0EIR0
names: Similarity
messages: Belongs to the aldose epimerase family.

1045858:BINT RS09400
gene id: 1045858:BINT_RS09400
uniprot id: G0EK52
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

1045858:BINT RS07950
gene id: 1045858:BINT_RS07950
uniprot id: G0EI70
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1045858:BINT RS04085
gene id: 1045858:BINT_RS04085
uniprot id: G0EL72
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1045858:BINT RS09155
gene id: 1045858:BINT_RS09155
uniprot id: G0EJS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1045858:BINT RS12635
gene id: 1045858:BINT_RS12635
uniprot id: G0ENT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1045858:BINT RS07935
gene id: 1045858:BINT_RS07935
uniprot id: G0EI67
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1045858:BINT RS01515
gene id: 1045858:BINT_RS01515
uniprot id: G0EHY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1045858:BINT RS10945
gene id: 1045858:BINT_RS10945
uniprot id: G0ELY1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

1045858:BINT RS01115
gene id: 1045858:BINT_RS01115
uniprot id: G0EQF9
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1045858:BINT RS01990
gene id: 1045858:BINT_RS01990
uniprot id: G0EIN1
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS03090
gene id: 1045858:BINT_RS03090
uniprot id: G0EJY5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1045858:BINT RS12420
gene id: 1045858:BINT_RS12420
uniprot id: G0ENP7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1045858:BINT RS11930
gene id: 1045858:BINT_RS11930
uniprot id: G0EMY8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1045858:BINT RS02490
gene id: 1045858:BINT_RS02490
uniprot id: G0EJD7
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1045858:BINT RS05525
gene id: 1045858:BINT_RS05525
uniprot id: G0EMP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1045858:BINT RS09980
gene id: 1045858:BINT_RS09980
uniprot id: G0EKX9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

1045858:BINT RS09200
gene id: 1045858:BINT_RS09200
uniprot id: G0EK12
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS01480
gene id: 1045858:BINT_RS01480
uniprot id: G0EHX4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1045858:BINT RS07685
gene id: 1045858:BINT_RS07685
uniprot id: G0EI19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1045858:BINT RS04125
gene id: 1045858:BINT_RS04125
uniprot id: G0EL80
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1045858:BINT RS12510
gene id: 1045858:BINT_RS12510
uniprot id: G0ENR4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1045858:BINT RS02800
gene id: 1045858:BINT_RS02800
uniprot id: G0EJJ4
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS02265
gene id: 1045858:BINT_RS02265
uniprot id: G0EJ13
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1045858:BINT RS08000
gene id: 1045858:BINT_RS08000
uniprot id: G0EIN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1045858:BINT RS01100
gene id: 1045858:BINT_RS01100
uniprot id: G0EQF6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS08660
gene id: 1045858:BINT_RS08660
uniprot id: G0EJ95
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1045858:BINT RS07790
gene id: 1045858:BINT_RS07790
uniprot id: G0EI40
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

1045858:BINT RS13185
gene id: 1045858:BINT_RS13185
uniprot id: G0EQ17
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1045858:BINT RS05500
gene id: 1045858:BINT_RS05500
uniprot id: G0EMN8
names: Subcellular Location Annotation
messages: Cytoplasm

1045858:BINT RS05505
gene id: 1045858:BINT_RS05505
uniprot id: G0EMN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS01630
gene id: 1045858:BINT_RS01630
uniprot id: G0EIF9
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1045858:BINT RS09450
gene id: 1045858:BINT_RS09450
uniprot id: G0EK62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1045858:BINT RS14105
gene id: 1045858:BINT_RS14105
uniprot id: G0EI99
names: Similarity
messages: Belongs to the aspartokinase family.

1045858:BINT RS10140
gene id: 1045858:BINT_RS10140
uniprot id: G0EL12
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

1045858:BINT RS04895
gene id: 1045858:BINT_RS04895
uniprot id: G0EM38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1045858:BINT RS09475
gene id: 1045858:BINT_RS09475
uniprot id: G0EK67
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1045858:BINT RS09190
gene id: 1045858:BINT_RS09190
uniprot id: G0EK10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1045858:BINT RS02510
gene id: 1045858:BINT_RS02510
uniprot id: G0EJE1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1045858:BINT RS04060
gene id: 1045858:BINT_RS04060
uniprot id: G0EL68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1045858:BINT RS02180
gene id: 1045858:BINT_RS02180
uniprot id: G0EIZ8
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1045858:BINT RS05090
gene id: 1045858:BINT_RS05090
uniprot id: G0EM75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1045858:BINT RS02005
gene id: 1045858:BINT_RS02005
uniprot id: G0EIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1045858:BINT RS10155
gene id: 1045858:BINT_RS10155
uniprot id: G0EL16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

1045858:BINT RS09345
gene id: 1045858:BINT_RS09345
uniprot id: G0EK41
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1045858:BINT RS09270
gene id: 1045858:BINT_RS09270
uniprot id: G0EK26
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1045858:BINT RS09320
gene id: 1045858:BINT_RS09320
uniprot id: G0EK36
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.

1045858:BINT RS08965
gene id: 1045858:BINT_RS08965
uniprot id: G0EJN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1045858:BINT RS10580
gene id: 1045858:BINT_RS10580
uniprot id: G0ELI0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1045858:BINT RS04475
gene id: 1045858:BINT_RS04475
uniprot id: G0ELM7
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1045858:BINT RS08025
gene id: 1045858:BINT_RS08025
uniprot id: G0EIP2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1045858:BINT RS03360
gene id: 1045858:BINT_RS03360
uniprot id: G0EKB9
names: Similarity
messages: Belongs to the RutC family.

1045858:BINT RS11785
gene id: 1045858:BINT_RS11785
uniprot id: G0EMV7
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS13970
gene id: 1045858:BINT_RS13970
uniprot id: G0EI76
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1045858:BINT RS02270
gene id: 1045858:BINT_RS02270
uniprot id: G0EJ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1045858:BINT RS01325
gene id: 1045858:BINT_RS01325
uniprot id: G0EHU4
names: Caution
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS05780
gene id: 1045858:BINT_RS05780
uniprot id: G0EN22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1045858:BINT RS12415
gene id: 1045858:BINT_RS12415
uniprot id: G0ENP6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

1045858:BINT RS09730
gene id: 1045858:BINT_RS09730
uniprot id: G0EKJ8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1045858:BINT RS11555
gene id: 1045858:BINT_RS11555
uniprot id: G0EMI2
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS12430
gene id: 1045858:BINT_RS12430
uniprot id: G0ENP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1045858:BINT RS12285
gene id: 1045858:BINT_RS12285
uniprot id: G0ENE0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1045858:BINT RS09465
gene id: 1045858:BINT_RS09465
uniprot id: G0EK65
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1045858:BINT RS08360
gene id: 1045858:BINT_RS08360
uniprot id: G0EIW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1045858:BINT RS01870
gene id: 1045858:BINT_RS01870
uniprot id: G0EIK7
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1045858:BINT RS00055
gene id: 1045858:BINT_RS00055
uniprot id: G0ENX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1045858:BINT RS10075
gene id: 1045858:BINT_RS10075
uniprot id: G0EKZ8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1045858:BINT RS05910
gene id: 1045858:BINT_RS05910
uniprot id: G0EN50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1045858:BINT RS08605
gene id: 1045858:BINT_RS08605
uniprot id: G0EJ84
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS01570
gene id: 1045858:BINT_RS01570
uniprot id: G0EHZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1045858:BINT RS12865
gene id: 1045858:BINT_RS12865
uniprot id: G0EPE0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1045858:BINT RS04525
gene id: 1045858:BINT_RS04525
uniprot id: G0ELN4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1045858:BINT RS04280
gene id: 1045858:BINT_RS04280
uniprot id: G0ELA9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

1045858:BINT RS07240
gene id: 1045858:BINT_RS07240
uniprot id: G0EQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1045858:BINT RS08020
gene id: 1045858:BINT_RS08020
uniprot id: G0EIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1045858:BINT RS02770
gene id: 1045858:BINT_RS02770
uniprot id: G0EJI8
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS00710
gene id: 1045858:BINT_RS00710
uniprot id: G0EPR8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS11185
gene id: 1045858:BINT_RS11185
uniprot id: G0EMA5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS01940
gene id: 1045858:BINT_RS01940
uniprot id: G0EIM1
names: Similarity
messages: Belongs to the class-I fumarase family.

1045858:BINT RS12245
gene id: 1045858:BINT_RS12245
uniprot id: G0END2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1045858:BINT RS08575
gene id: 1045858:BINT_RS08575
uniprot id: G0EJ80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1045858:BINT RS03190
gene id: 1045858:BINT_RS03190
uniprot id: G0EK04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1045858:BINT RS02150
gene id: 1045858:BINT_RS02150
uniprot id: G0EIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1045858:BINT RS09580
gene id: 1045858:BINT_RS09580
uniprot id: G0EKG8
names: Similarity
messages: Belongs to the carbamate kinase family.

1045858:BINT RS14225
gene id: 1045858:BINT_RS14225
uniprot id: G0EIC2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1045858:BINT RS09820
gene id: 1045858:BINT_RS09820
uniprot id: G0EKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1045858:BINT RS14930
gene id: 1045858:BINT_RS14930
uniprot id: G0EKX1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1045858:BINT RS00720
gene id: 1045858:BINT_RS00720
uniprot id: G0EPS0
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS00280
gene id: 1045858:BINT_RS00280
uniprot id: G0EP18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1045858:BINT RS14320
gene id: 1045858:BINT_RS14320
uniprot id: G0EIE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS03160
gene id: 1045858:BINT_RS03160
uniprot id: G0EJZ8
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS01545
gene id: 1045858:BINT_RS01545
uniprot id: G0EHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1045858:BINT RS12235
gene id: 1045858:BINT_RS12235
uniprot id: G0END0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1045858:BINT RS03640
gene id: 1045858:BINT_RS03640
uniprot id: G0EKQ4
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1045858:BINT RS13675
gene id: 1045858:BINT_RS13675
uniprot id: G0EQS6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1045858:BINT RS07860
gene id: 1045858:BINT_RS07860
uniprot id: G0EI54
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus membrane

1045858:BINT RS03175
gene id: 1045858:BINT_RS03175
uniprot id: G0EK01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1045858:BINT RS03115
gene id: 1045858:BINT_RS03115
uniprot id: G0EJZ0
names: Similarity
messages: Belongs to the DapA family.

1045858:BINT RS09015
gene id: 1045858:BINT_RS09015
uniprot id: G0EJP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L-fucose isomerase family.
messages: Converts the aldose L-fucose into the corresponding ketose L-fuculose.
messages: Cytoplasm

1045858:BINT RS03890
gene id: 1045858:BINT_RS03890
uniprot id: G0EKV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1045858:BINT RS02520
gene id: 1045858:BINT_RS02520
uniprot id: G0EJE3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1045858:BINT RS09365
gene id: 1045858:BINT_RS09365
uniprot id: G0EK45
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1045858:BINT RS11155
gene id: 1045858:BINT_RS11155
uniprot id: G0EM21
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1045858:BINT RS14150
gene id: 1045858:BINT_RS14150
uniprot id: G0EIA6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1045858:BINT RS08805
gene id: 1045858:BINT_RS08805
uniprot id: G0EJK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1045858:BINT RS01245
gene id: 1045858:BINT_RS01245
uniprot id: G0EHS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1045858:BINT RS06830
gene id: 1045858:BINT_RS06830
uniprot id: G0EPT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1045858:BINT RS07795
gene id: 1045858:BINT_RS07795
uniprot id: G0EI41
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1045858:BINT RS06575
gene id: 1045858:BINT_RS06575
uniprot id: G0EP74
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS03515
gene id: 1045858:BINT_RS03515
uniprot id: G0EKF0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

1045858:BINT RS08145
gene id: 1045858:BINT_RS08145
uniprot id: G0EIR6
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS12225
gene id: 1045858:BINT_RS12225
uniprot id: G0ENC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1045858:BINT RS01525
gene id: 1045858:BINT_RS01525
uniprot id: G0EHY2
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1045858:BINT RS12545
gene id: 1045858:BINT_RS12545
uniprot id: G0ENS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1045858:BINT RS05020
gene id: 1045858:BINT_RS05020
uniprot id: G0EM63
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1045858:BINT RS07295
gene id: 1045858:BINT_RS07295
uniprot id: G0EQJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

1045858:BINT RS12560
gene id: 1045858:BINT_RS12560
uniprot id: G0ENS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1045858:BINT RS08335
gene id: 1045858:BINT_RS08335
uniprot id: G0EIV6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1045858:BINT RS13040
gene id: 1045858:BINT_RS13040
uniprot id: G0EPH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1045858:BINT RS00170
gene id: 1045858:BINT_RS00170
uniprot id: G0ENZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1045858:BINT RS12185
gene id: 1045858:BINT_RS12185
uniprot id: G0ENC0
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

1045858:BINT RS08055
gene id: 1045858:BINT_RS08055
uniprot id: G0EIP8
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1045858:BINT RS01360
gene id: 1045858:BINT_RS01360
uniprot id: G0EHV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1045858:BINT RS12305
gene id: 1045858:BINT_RS12305
uniprot id: G0ENE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1045858:BINT RS06770
gene id: 1045858:BINT_RS06770
uniprot id: G0EPB5
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1045858:BINT RS06460
gene id: 1045858:BINT_RS06460
uniprot id: G0EP52
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS05035
gene id: 1045858:BINT_RS05035
uniprot id: G0EM66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1045858:BINT RS08100
gene id: 1045858:BINT_RS08100
uniprot id: G0EIQ7
names: Similarity
messages: Belongs to the peptidase U62 family.

1045858:BINT RS02465
gene id: 1045858:BINT_RS02465
uniprot id: G0EJD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS11780
gene id: 1045858:BINT_RS11780
uniprot id: G0EMV6
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

1045858:BINT RS11585
gene id: 1045858:BINT_RS11585
uniprot id: G0EMR8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1045858:BINT RS03340
gene id: 1045858:BINT_RS03340
uniprot id: G0EKB5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1045858:BINT RS10450
gene id: 1045858:BINT_RS10450
uniprot id: G0ELF6
names: Similarity
messages: Belongs to the ribF family.

1045858:BINT RS08350
gene id: 1045858:BINT_RS08350
uniprot id: G0EIV9
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1045858:BINT RS06370
gene id: 1045858:BINT_RS06370
uniprot id: G0ENM5
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1045858:BINT RS03475
gene id: 1045858:BINT_RS03475
uniprot id: G0EKE2
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS00725
gene id: 1045858:BINT_RS00725
uniprot id: G0EPS1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1045858:BINT RS04815
gene id: 1045858:BINT_RS04815
uniprot id: G0EM24
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1045858:BINT RS14195
gene id: 1045858:BINT_RS14195
uniprot id: G0EIB6
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1045858:BINT RS03420
gene id: 1045858:BINT_RS03420
uniprot id: G0EKD1
names: Similarity
messages: Belongs to the UPF0145 family.

1045858:BINT RS06995
gene id: 1045858:BINT_RS06995
uniprot id: G0EPX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS13680
gene id: 1045858:BINT_RS13680
uniprot id: G0EQS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1045858:BINT RS07340
gene id: 1045858:BINT_RS07340
uniprot id: G0EQK3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS03805
gene id: 1045858:BINT_RS03805
uniprot id: G0EKT8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1045858:BINT RS13255
gene id: 1045858:BINT_RS13255
uniprot id: G0EQ30
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1045858:BINT RS05725
gene id: 1045858:BINT_RS05725
uniprot id: G0EN11
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS04320
gene id: 1045858:BINT_RS04320
uniprot id: G0ELB7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1045858:BINT RS12445
gene id: 1045858:BINT_RS12445
uniprot id: G0ENQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1045858:BINT RS07690
gene id: 1045858:BINT_RS07690
uniprot id: G0EI20
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1045858:BINT RS06215
gene id: 1045858:BINT_RS06215
uniprot id: G0ENJ4
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1045858:BINT RS03470
gene id: 1045858:BINT_RS03470
uniprot id: G0EKE1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1045858:BINT RS08775
gene id: 1045858:BINT_RS08775
uniprot id: G0EJJ7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1045858:BINT RS11675
gene id: 1045858:BINT_RS11675
uniprot id: G0EMT5
names: Similarity
messages: Belongs to the acylphosphatase family.

1045858:BINT RS13280
gene id: 1045858:BINT_RS13280
uniprot id: G0EQ36
names: Similarity
messages: Belongs to the UPF0102 family.

1045858:BINT RS10500
gene id: 1045858:BINT_RS10500
uniprot id: G0ELG5
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

1045858:BINT RS01935
gene id: 1045858:BINT_RS01935
uniprot id: G0EIM0
names: Similarity
messages: Belongs to the class-I fumarase family.

1045858:BINT RS11610
gene id: 1045858:BINT_RS11610
uniprot id: G0EMS2
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10115
gene id: 1045858:BINT_RS10115
uniprot id: G0EL07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1045858:BINT RS05010
gene id: 1045858:BINT_RS05010
uniprot id: G0EM61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1045858:BINT RS04700
gene id: 1045858:BINT_RS04700
uniprot id: G0ELR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1045858:BINT RS01450
gene id: 1045858:BINT_RS01450
uniprot id: G0EHW8
names: Similarity
messages: Belongs to the BMP lipoprotein family.

1045858:BINT RS02670
gene id: 1045858:BINT_RS02670
uniprot id: G0EJG9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1045858:BINT RS08400
gene id: 1045858:BINT_RS08400
uniprot id: G0EJ47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1045858:BINT RS07290
gene id: 1045858:BINT_RS07290
uniprot id: G0EQJ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS13985
gene id: 1045858:BINT_RS13985
uniprot id: G0EI79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS02060
gene id: 1045858:BINT_RS02060
uniprot id: G0EIX4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS13980
gene id: 1045858:BINT_RS13980
uniprot id: G0EI78
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1045858:BINT RS10070
gene id: 1045858:BINT_RS10070
uniprot id: G0EKZ7
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

1045858:BINT RS04790
gene id: 1045858:BINT_RS04790
uniprot id: G0ELT8
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS11805
gene id: 1045858:BINT_RS11805
uniprot id: G0EMW1
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS02920
gene id: 1045858:BINT_RS02920
uniprot id: G0EJU9
names: Function
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1045858:BINT RS14235
gene id: 1045858:BINT_RS14235
uniprot id: G0EIC4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS03520
gene id: 1045858:BINT_RS03520
uniprot id: G0EKF1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

1045858:BINT RS04360
gene id: 1045858:BINT_RS04360
uniprot id: G0ELC5
names: Similarity
messages: Belongs to the UPF0597 family.

1045858:BINT RS02925
gene id: 1045858:BINT_RS02925
uniprot id: G0EJV0
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1045858:BINT RS01650
gene id: 1045858:BINT_RS01650
uniprot id: G0EIG3
names: Similarity
messages: Belongs to the UPF0047 family.

1045858:BINT RS08030
gene id: 1045858:BINT_RS08030
uniprot id: G0EIP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1045858:BINT RS12495
gene id: 1045858:BINT_RS12495
uniprot id: G0ENR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1045858:BINT RS03165
gene id: 1045858:BINT_RS03165
uniprot id: G0EJZ9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1045858:BINT RS00780
gene id: 1045858:BINT_RS00780
uniprot id: G0EPT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1045858:BINT RS13660
gene id: 1045858:BINT_RS13660
uniprot id: G0EQS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1045858:BINT RS12330
gene id: 1045858:BINT_RS12330
uniprot id: G0ENE9
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1045858:BINT RS11320
gene id: 1045858:BINT_RS11320
uniprot id: G0EMD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1045858:BINT RS13695
gene id: 1045858:BINT_RS13695
uniprot id: G0EQT0
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS13500
gene id: 1045858:BINT_RS13500
uniprot id: G0EQ79
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1045858:BINT RS05470
gene id: 1045858:BINT_RS05470
uniprot id: G0EMN2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1045858:BINT RS00185
gene id: 1045858:BINT_RS00185
uniprot id: G0EP00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1045858:BINT RS14155
gene id: 1045858:BINT_RS14155
uniprot id: G0EIA7
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1045858:BINT RS14270
gene id: 1045858:BINT_RS14270
uniprot id: G0EID2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1045858:BINT RS13735
gene id: 1045858:BINT_RS13735
uniprot id: G0EQT8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1045858:BINT RS00180
gene id: 1045858:BINT_RS00180
uniprot id: G0ENZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1045858:BINT RS10355
gene id: 1045858:BINT_RS10355
uniprot id: G0EL57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1045858:BINT RS09500
gene id: 1045858:BINT_RS09500
uniprot id: G0EK72
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1045858:BINT RS07225
gene id: 1045858:BINT_RS07225
uniprot id: G0EQI0
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

1045858:BINT RS03500
gene id: 1045858:BINT_RS03500
uniprot id: G0EKE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1045858:BINT RS09115
gene id: 1045858:BINT_RS09115
uniprot id: G0EJR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1045858:BINT RS10350
gene id: 1045858:BINT_RS10350
uniprot id: G0EL56
names: Similarity
messages: Belongs to the methyltransferase superfamily. PrmA family.

1045858:BINT RS08680
gene id: 1045858:BINT_RS08680
uniprot id: G0EJ99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1045858:BINT RS03660
gene id: 1045858:BINT_RS03660
uniprot id: G0EKQ8
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1045858:BINT RS02275
gene id: 1045858:BINT_RS02275
uniprot id: G0EJ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1045858:BINT RS03655
gene id: 1045858:BINT_RS03655
uniprot id: G0EKQ7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1045858:BINT RS04290
gene id: 1045858:BINT_RS04290
uniprot id: G0ELB1
names: Similarity
messages: Belongs to the thioredoxin family.

1045858:BINT RS08960
gene id: 1045858:BINT_RS08960
uniprot id: G0EJN3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1045858:BINT RS05485
gene id: 1045858:BINT_RS05485
uniprot id: G0EMN5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane

1045858:BINT RS12015
gene id: 1045858:BINT_RS12015
uniprot id: G0EN87
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1045858:BINT RS05265
gene id: 1045858:BINT_RS05265
uniprot id: G0EMJ1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1045858:BINT RS12255
gene id: 1045858:BINT_RS12255
uniprot id: G0END4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1045858:BINT RS05330
gene id: 1045858:BINT_RS05330
uniprot id: G0EMK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1045858:BINT RS11195
gene id: 1045858:BINT_RS11195
uniprot id: G0EMA7
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1045858:BINT RS05370
gene id: 1045858:BINT_RS05370
uniprot id: G0EML2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1045858:BINT RS11560
gene id: 1045858:BINT_RS11560
uniprot id: G0EMR3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1045858:BINT RS07440
gene id: 1045858:BINT_RS07440
uniprot id: G0EQM4
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS10100
gene id: 1045858:BINT_RS10100
uniprot id: G0EL03
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS06235
gene id: 1045858:BINT_RS06235
uniprot id: G0ENJ8
names: Subcellular Location Annotation
messages: Mitochondrion

1045858:BINT RS14210
gene id: 1045858:BINT_RS14210
uniprot id: G0EIB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1045858:BINT RS02795
gene id: 1045858:BINT_RS02795
uniprot id: G0EJJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1045858:BINT RS08180
gene id: 1045858:BINT_RS08180
uniprot id: G0EIS4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1045858:BINT RS08800
gene id: 1045858:BINT_RS08800
uniprot id: G0EJK2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1045858:BINT RS07805
gene id: 1045858:BINT_RS07805
uniprot id: G0EI43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

1045858:BINT RS10650
gene id: 1045858:BINT_RS10650
uniprot id: G0ELJ4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1045858:BINT RS01740
gene id: 1045858:BINT_RS01740
uniprot id: G0EII1
names: Similarity
messages: Belongs to the thymidylate kinase family.

1045858:BINT RS01380
gene id: 1045858:BINT_RS01380
uniprot id: G0EHV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1045858:BINT RS12090
gene id: 1045858:BINT_RS12090
uniprot id: G0ENA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1045858:BINT RS03410
gene id: 1045858:BINT_RS03410
uniprot id: G0EKC9
names: Similarity
messages: Belongs to the LOG family.

1045858:BINT RS00165
gene id: 1045858:BINT_RS00165
uniprot id: G0ENZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1045858:BINT RS01045
gene id: 1045858:BINT_RS01045
uniprot id: G0EQE4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1045858:BINT RS11520
gene id: 1045858:BINT_RS11520
uniprot id: G0EMH4
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1045858:BINT RS08205
gene id: 1045858:BINT_RS08205
uniprot id: G0EIS9
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

1045858:BINT RS11630
gene id: 1045858:BINT_RS11630
uniprot id: G0EMS6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1045858:BINT RS04530
gene id: 1045858:BINT_RS04530
uniprot id: G0ELN5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1045858:BINT RS13855
gene id: 1045858:BINT_RS13855
uniprot id: G0EQW2
names: Similarity
messages: Belongs to the hemerythrin family.

1045858:BINT RS13745
gene id: 1045858:BINT_RS13745
uniprot id: G0EQU0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1045858:BINT RS03570
gene id: 1045858:BINT_RS03570
uniprot id: G0EKG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1045858:BINT RS12905
gene id: 1045858:BINT_RS12905
uniprot id: G0EPE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

1045858:BINT RS11305
gene id: 1045858:BINT_RS11305
uniprot id: G0EMC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

1045858:BINT RS14280
gene id: 1045858:BINT_RS14280
uniprot id: G0EID4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1045858:BINT RS08035
gene id: 1045858:BINT_RS08035
uniprot id: G0EIP4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1045858:BINT RS04415
gene id: 1045858:BINT_RS04415
uniprot id: G0ELD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1045858:BINT RS01265
gene id: 1045858:BINT_RS01265
uniprot id: G0EHT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1045858:BINT RS13710
gene id: 1045858:BINT_RS13710
uniprot id: G0EQT3
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

1045858:BINT RS04765
gene id: 1045858:BINT_RS04765
uniprot id: G0ELT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

1045858:BINT RS08235
gene id: 1045858:BINT_RS08235
uniprot id: G0EIT6
names: Subcellular Location Annotation
messages: Membrane

1045858:BINT RS02430
gene id: 1045858:BINT_RS02430
uniprot id: G0EJC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1045858:BINT RS13715
gene id: 1045858:BINT_RS13715
uniprot id: G0EQT4
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

1045858:BINT RS13075
gene id: 1045858:BINT_RS13075
uniprot id: G0EPI4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1045858:BINT RS01475
gene id: 1045858:BINT_RS01475
uniprot id: G0EHX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1045858:BINT RS03070
gene id: 1045858:BINT_RS03070
uniprot id: G0EJY1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

1045858:BINT RS07895
gene id: 1045858:BINT_RS07895
uniprot id: G0EI59
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1045858:BINT RS12230
gene id: 1045858:BINT_RS12230
uniprot id: G0ENC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.