1006006:MCUP RS07785
gene id: 1006006:MCUP_RS07785
uniprot id: F4FZZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS00815
gene id: 1006006:MCUP_RS00815
uniprot id: F4FYE8
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1006006:MCUP RS00180
gene id: 1006006:MCUP_RS00180
uniprot id: F4FXU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1006006:MCUP RS02985
gene id: 1006006:MCUP_RS02985
uniprot id: F4G0Z8
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1006006:MCUP RS02475
gene id: 1006006:MCUP_RS02475
uniprot id: F4G093
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1006006:MCUP RS07625
gene id: 1006006:MCUP_RS07625
uniprot id: F4FZW3
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS09215
gene id: 1006006:MCUP_RS09215
uniprot id: F4G1N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

1006006:MCUP RS00035
gene id: 1006006:MCUP_RS00035
uniprot id: F4G3C0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1006006:MCUP RS05260
gene id: 1006006:MCUP_RS05260
uniprot id: F4G309
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1006006:MCUP RS01225
gene id: 1006006:MCUP_RS01225
uniprot id: F4FYV8
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

1006006:MCUP RS06740
gene id: 1006006:MCUP_RS06740
uniprot id: F4FYP1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1006006:MCUP RS03995
gene id: 1006006:MCUP_RS03995
uniprot id: F4G203
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS01995
gene id: 1006006:MCUP_RS01995
uniprot id: F4FZR8
names: Similarity
messages: Belongs to the complex I subunit 3 family.

1006006:MCUP RS09305
gene id: 1006006:MCUP_RS09305
uniprot id: F4G1Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1006006:MCUP RS07730
gene id: 1006006:MCUP_RS07730
uniprot id: F4FZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1006006:MCUP RS09290
gene id: 1006006:MCUP_RS09290
uniprot id: F4G1Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1006006:MCUP RS04795
gene id: 1006006:MCUP_RS04795
uniprot id: F4G2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1006006:MCUP RS00740
gene id: 1006006:MCUP_RS00740
uniprot id: F4FYD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1006006:MCUP RS02955
gene id: 1006006:MCUP_RS02955
uniprot id: F4G0Z2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1006006:MCUP RS03065
gene id: 1006006:MCUP_RS03065
uniprot id: F4G113
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1006006:MCUP RS05885
gene id: 1006006:MCUP_RS05885
uniprot id: F4G3I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1006006:MCUP RS01410
gene id: 1006006:MCUP_RS01410
uniprot id: F4FZ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1006006:MCUP RS00440
gene id: 1006006:MCUP_RS00440
uniprot id: F4FXZ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

1006006:MCUP RS01240
gene id: 1006006:MCUP_RS01240
uniprot id: F4FYW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1006006:MCUP RS00700
gene id: 1006006:MCUP_RS00700
uniprot id: F4FYC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1006006:MCUP RS04345
gene id: 1006006:MCUP_RS04345
uniprot id: F4G2B8
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS08805
gene id: 1006006:MCUP_RS08805
uniprot id: F4G182
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

1006006:MCUP RS06815
gene id: 1006006:MCUP_RS06815
uniprot id: F4FYY5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

1006006:MCUP RS04160
gene id: 1006006:MCUP_RS04160
uniprot id: F4G280
names: Similarity
messages: Belongs to the pyruvate kinase family.

1006006:MCUP RS02750
gene id: 1006006:MCUP_RS02750
uniprot id: F4G0M6
names: Function
names: Similarity
messages: Belongs to the TrpA family.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1006006:MCUP RS00315
gene id: 1006006:MCUP_RS00315
uniprot id: F4FXX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1006006:MCUP RS00655
gene id: 1006006:MCUP_RS00655
uniprot id: F4FYB8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1006006:MCUP RS00330
gene id: 1006006:MCUP_RS00330
uniprot id: F4FXX4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS03215
gene id: 1006006:MCUP_RS03215
uniprot id: F4G143
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS09360
gene id: 1006006:MCUP_RS09360
uniprot id: F4G1R8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1006006:MCUP RS00185
gene id: 1006006:MCUP_RS00185
uniprot id: F4FXU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1006006:MCUP RS05255
gene id: 1006006:MCUP_RS05255
uniprot id: F4G2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

1006006:MCUP RS08645
gene id: 1006006:MCUP_RS08645
uniprot id: F4G0X7
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1006006:MCUP RS00285
gene id: 1006006:MCUP_RS00285
uniprot id: F4FXW7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

1006006:MCUP RS08840
gene id: 1006006:MCUP_RS08840
uniprot id: F4G189
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1006006:MCUP RS04205
gene id: 1006006:MCUP_RS04205
uniprot id: F4G289
names: Similarity
messages: Belongs to the RutC family.

1006006:MCUP RS00790
gene id: 1006006:MCUP_RS00790
uniprot id: F4FYE5
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS06010
gene id: 1006006:MCUP_RS06010
uniprot id: F4G3L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

1006006:MCUP RS03500
gene id: 1006006:MCUP_RS03500
uniprot id: F4G1H2
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

1006006:MCUP RS08165
gene id: 1006006:MCUP_RS08165
uniprot id: F4G0E6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

1006006:MCUP RS05105
gene id: 1006006:MCUP_RS05105
uniprot id: F4G2U5
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS03610
gene id: 1006006:MCUP_RS03610
uniprot id: F4G1K2
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS09550
gene id: 1006006:MCUP_RS09550
uniprot id: F4G229
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1006006:MCUP RS00190
gene id: 1006006:MCUP_RS00190
uniprot id: F4FXU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

1006006:MCUP RS09280
gene id: 1006006:MCUP_RS09280
uniprot id: F4G1Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1006006:MCUP RS02590
gene id: 1006006:MCUP_RS02590
uniprot id: F4G0J6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1006006:MCUP RS01845
gene id: 1006006:MCUP_RS01845
uniprot id: F4FZN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1006006:MCUP RS01860
gene id: 1006006:MCUP_RS01860
uniprot id: F4FZP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1006006:MCUP RS05670
gene id: 1006006:MCUP_RS05670
uniprot id: F4G3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1006006:MCUP RS09330
gene id: 1006006:MCUP_RS09330
uniprot id: F4G1R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1006006:MCUP RS09695
gene id: 1006006:MCUP_RS09695
uniprot id: F4G258
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1006006:MCUP RS02430
gene id: 1006006:MCUP_RS02430
uniprot id: F4G084
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1006006:MCUP RS09235
gene id: 1006006:MCUP_RS09235
uniprot id: F4G1P2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1006006:MCUP RS07470
gene id: 1006006:MCUP_RS07470
uniprot id: F4FZK1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1006006:MCUP RS05685
gene id: 1006006:MCUP_RS05685
uniprot id: F4G3E8
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1006006:MCUP RS09540
gene id: 1006006:MCUP_RS09540
uniprot id: F4G228
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1006006:MCUP RS04630
gene id: 1006006:MCUP_RS04630
uniprot id: F4G2H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1006006:MCUP RS04870
gene id: 1006006:MCUP_RS04870
uniprot id: F4G2N5
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS09455
gene id: 1006006:MCUP_RS09455
uniprot id: F4G1T5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1006006:MCUP RS09560
gene id: 1006006:MCUP_RS09560
uniprot id: F4G231
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

1006006:MCUP RS02885
gene id: 1006006:MCUP_RS02885
uniprot id: F4G0Q4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1006006:MCUP RS09480
gene id: 1006006:MCUP_RS09480
uniprot id: F4G1U0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1006006:MCUP RS00780
gene id: 1006006:MCUP_RS00780
uniprot id: F4FYE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

1006006:MCUP RS02265
gene id: 1006006:MCUP_RS02265
uniprot id: F4G051
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1006006:MCUP RS00730
gene id: 1006006:MCUP_RS00730
uniprot id: F4FYD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS09660
gene id: 1006006:MCUP_RS09660
uniprot id: F4G251
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1006006:MCUP RS00990
gene id: 1006006:MCUP_RS00990
uniprot id: F4FYR4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1006006:MCUP RS03410
gene id: 1006006:MCUP_RS03410
uniprot id: F4G1F4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1006006:MCUP RS02855
gene id: 1006006:MCUP_RS02855
uniprot id: F4G0P8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1006006:MCUP RS00200
gene id: 1006006:MCUP_RS00200
uniprot id: F4FXV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1006006:MCUP RS00375
gene id: 1006006:MCUP_RS00375
uniprot id: F4FXY3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1006006:MCUP RS06865
gene id: 1006006:MCUP_RS06865
uniprot id: F4FYZ6
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS07565
gene id: 1006006:MCUP_RS07565
uniprot id: F4FZV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1006006:MCUP RS03380
gene id: 1006006:MCUP_RS03380
uniprot id: F4G1E8
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1006006:MCUP RS01510
gene id: 1006006:MCUP_RS01510
uniprot id: F4FZ94
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

1006006:MCUP RS07075
gene id: 1006006:MCUP_RS07075
uniprot id: F4FZ40
names: Similarity
messages: Belongs to the RuvB family.

1006006:MCUP RS09375
gene id: 1006006:MCUP_RS09375
uniprot id: F4G1S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1006006:MCUP RS07130
gene id: 1006006:MCUP_RS07130
uniprot id: F4FZ50
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1006006:MCUP RS09495
gene id: 1006006:MCUP_RS09495
uniprot id: F4G1U1
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1006006:MCUP RS07675
gene id: 1006006:MCUP_RS07675
uniprot id: F4FZX3
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

1006006:MCUP RS03095
gene id: 1006006:MCUP_RS03095
uniprot id: F4G119
names: Similarity
messages: Belongs to the PDCD5 family.

1006006:MCUP RS09390
gene id: 1006006:MCUP_RS09390
uniprot id: F4G1S3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

1006006:MCUP RS02000
gene id: 1006006:MCUP_RS02000
uniprot id: F4FZR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

1006006:MCUP RS03645
gene id: 1006006:MCUP_RS03645
uniprot id: F4G1K9
names: Similarity
messages: Belongs to the UPF0111 family.

1006006:MCUP RS01285
gene id: 1006006:MCUP_RS01285
uniprot id: F4FYX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1006006:MCUP RS07460
gene id: 1006006:MCUP_RS07460
uniprot id: F4FZJ9
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS02880
gene id: 1006006:MCUP_RS02880
uniprot id: F4G0Q3
names: Similarity
messages: Belongs to the GcvT family.

1006006:MCUP RS04385
gene id: 1006006:MCUP_RS04385
uniprot id: F4G2C6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1006006:MCUP RS02990
gene id: 1006006:MCUP_RS02990
uniprot id: F4G0Z9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

1006006:MCUP RS02820
gene id: 1006006:MCUP_RS02820
uniprot id: F4G0P1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1006006:MCUP RS00640
gene id: 1006006:MCUP_RS00640
uniprot id: F4FYB7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

1006006:MCUP RS06270
gene id: 1006006:MCUP_RS06270
uniprot id: F4FY70
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS08055
gene id: 1006006:MCUP_RS08055
uniprot id: F4G0C4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1006006:MCUP RS01735
gene id: 1006006:MCUP_RS01735
uniprot id: F4FZD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1006006:MCUP RS09200
gene id: 1006006:MCUP_RS09200
uniprot id: F4G1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1006006:MCUP RS03085
gene id: 1006006:MCUP_RS03085
uniprot id: F4G117
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

1006006:MCUP RS01520
gene id: 1006006:MCUP_RS01520
uniprot id: F4FZ96
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1006006:MCUP RS03060
gene id: 1006006:MCUP_RS03060
uniprot id: F4G112
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1006006:MCUP RS01280
gene id: 1006006:MCUP_RS01280
uniprot id: F4FYW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1006006:MCUP RS00230
gene id: 1006006:MCUP_RS00230
uniprot id: F4FXV6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1006006:MCUP RS02875
gene id: 1006006:MCUP_RS02875
uniprot id: F4G0Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1006006:MCUP RS03100
gene id: 1006006:MCUP_RS03100
uniprot id: F4G120
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS09025
gene id: 1006006:MCUP_RS09025
uniprot id: F4G1C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS08535
gene id: 1006006:MCUP_RS08535
uniprot id: F4G0V3
names: Similarity
messages: Belongs to the pirin family.

1006006:MCUP RS05015
gene id: 1006006:MCUP_RS05015
uniprot id: F4G2S5
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS00840
gene id: 1006006:MCUP_RS00840
uniprot id: F4FYF2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1006006:MCUP RS09125
gene id: 1006006:MCUP_RS09125
uniprot id: F4G1M3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS02685
gene id: 1006006:MCUP_RS02685
uniprot id: F4G0L3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS00735
gene id: 1006006:MCUP_RS00735
uniprot id: F4FYD4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1006006:MCUP RS08475
gene id: 1006006:MCUP_RS08475
uniprot id: F4G0T9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1006006:MCUP RS01640
gene id: 1006006:MCUP_RS01640
uniprot id: F4FZB8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS09225
gene id: 1006006:MCUP_RS09225
uniprot id: F4G1P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1006006:MCUP RS03965
gene id: 1006006:MCUP_RS03965
uniprot id: F4G1Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1006006:MCUP RS02075
gene id: 1006006:MCUP_RS02075
uniprot id: F4FZT3
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS09245
gene id: 1006006:MCUP_RS09245
uniprot id: F4G1P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1006006:MCUP RS02835
gene id: 1006006:MCUP_RS02835
uniprot id: F4G0P4
names: Similarity
messages: Belongs to the AAA ATPase family.

1006006:MCUP RS09000
gene id: 1006006:MCUP_RS09000
uniprot id: F4G1B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

1006006:MCUP RS05965
gene id: 1006006:MCUP_RS05965
uniprot id: F4G3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1006006:MCUP RS03640
gene id: 1006006:MCUP_RS03640
uniprot id: F4G1K8
names: Similarity
messages: Belongs to the citrate synthase family.

1006006:MCUP RS08835
gene id: 1006006:MCUP_RS08835
uniprot id: F4G188
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

1006006:MCUP RS08250
gene id: 1006006:MCUP_RS08250
uniprot id: F4G0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1006006:MCUP RS04815
gene id: 1006006:MCUP_RS04815
uniprot id: F4G2M2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1006006:MCUP RS07980
gene id: 1006006:MCUP_RS07980
uniprot id: F4G0A9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1006006:MCUP RS00775
gene id: 1006006:MCUP_RS00775
uniprot id: F4FYE2
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

1006006:MCUP RS02285
gene id: 1006006:MCUP_RS02285
uniprot id: F4G055
names: Similarity
messages: Belongs to the UPF0201 family.

1006006:MCUP RS09270
gene id: 1006006:MCUP_RS09270
uniprot id: F4G1Q0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1006006:MCUP RS03050
gene id: 1006006:MCUP_RS03050
uniprot id: F4G110
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1006006:MCUP RS00605
gene id: 1006006:MCUP_RS00605
uniprot id: F4FYA9
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS01895
gene id: 1006006:MCUP_RS01895
uniprot id: F4FZP9
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

1006006:MCUP RS01965
gene id: 1006006:MCUP_RS01965
uniprot id: F4FZR2
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS06745
gene id: 1006006:MCUP_RS06745
uniprot id: F4FYP2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1006006:MCUP RS08940
gene id: 1006006:MCUP_RS08940
uniprot id: F4G1B0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1006006:MCUP RS07640
gene id: 1006006:MCUP_RS07640
uniprot id: F4FZW7
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS09080
gene id: 1006006:MCUP_RS09080
uniprot id: F4G1D5
names: Similarity
messages: Belongs to the glutaredoxin family.

1006006:MCUP RS06320
gene id: 1006006:MCUP_RS06320
uniprot id: F4FY82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1006006:MCUP RS02965
gene id: 1006006:MCUP_RS02965
uniprot id: F4G0Z4
names: Similarity
messages: Belongs to the SHMT family.

1006006:MCUP RS02420
gene id: 1006006:MCUP_RS02420
uniprot id: F4G082
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1006006:MCUP RS05455
gene id: 1006006:MCUP_RS05455
uniprot id: F4G370
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

1006006:MCUP RS01255
gene id: 1006006:MCUP_RS01255
uniprot id: F4FYW4
names: Similarity
messages: Belongs to the MCM family.

1006006:MCUP RS07805
gene id: 1006006:MCUP_RS07805
uniprot id: F4FZZ9
names: Similarity
messages: Belongs to the WrbA family.

1006006:MCUP RS02295
gene id: 1006006:MCUP_RS02295
uniprot id: F4G057
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1006006:MCUP RS02065
gene id: 1006006:MCUP_RS02065
uniprot id: F4FZT1
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS08555
gene id: 1006006:MCUP_RS08555
uniprot id: F4G0V8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1006006:MCUP RS01405
gene id: 1006006:MCUP_RS01405
uniprot id: F4FZ74
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1006006:MCUP RS08395
gene id: 1006006:MCUP_RS08395
uniprot id: F4G0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1006006:MCUP RS07190
gene id: 1006006:MCUP_RS07190
uniprot id: F4FZE2
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS07175
gene id: 1006006:MCUP_RS07175
uniprot id: F4FZ59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1006006:MCUP RS09635
gene id: 1006006:MCUP_RS09635
uniprot id: F4G246
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1006006:MCUP RS00755
gene id: 1006006:MCUP_RS00755
uniprot id: F4FYD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1006006:MCUP RS07055
gene id: 1006006:MCUP_RS07055
uniprot id: F4FZ36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS01875
gene id: 1006006:MCUP_RS01875
uniprot id: F4FZP5
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1006006:MCUP RS01725
gene id: 1006006:MCUP_RS01725
uniprot id: F4FZD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1006006:MCUP RS02490
gene id: 1006006:MCUP_RS02490
uniprot id: F4G096
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1006006:MCUP RS07755
gene id: 1006006:MCUP_RS07755
uniprot id: F4FZY9
names: Similarity
messages: Belongs to the DNA photolyase family.

1006006:MCUP RS07135
gene id: 1006006:MCUP_RS07135
uniprot id: F4FZ51
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1006006:MCUP RS01740
gene id: 1006006:MCUP_RS01740
uniprot id: F4FZD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1006006:MCUP RS00600
gene id: 1006006:MCUP_RS00600
uniprot id: F4FYA7
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

1006006:MCUP RS02260
gene id: 1006006:MCUP_RS02260
uniprot id: F4G050
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1006006:MCUP RS02385
gene id: 1006006:MCUP_RS02385
uniprot id: F4G074
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

1006006:MCUP RS06510
gene id: 1006006:MCUP_RS06510
uniprot id: F4FYJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1006006:MCUP RS08270
gene id: 1006006:MCUP_RS08270
uniprot id: F4G0G7
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 2 family.

1006006:MCUP RS04280
gene id: 1006006:MCUP_RS04280
uniprot id: F4G2A4
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1006006:MCUP RS07390
gene id: 1006006:MCUP_RS07390
uniprot id: F4FZI5
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS00170
gene id: 1006006:MCUP_RS00170
uniprot id: F4FXU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1006006:MCUP RS09450
gene id: 1006006:MCUP_RS09450
uniprot id: F4G1T4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1006006:MCUP RS04550
gene id: 1006006:MCUP_RS04550
uniprot id: F4G2F9
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS09365
gene id: 1006006:MCUP_RS09365
uniprot id: F4G1R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1006006:MCUP RS03045
gene id: 1006006:MCUP_RS03045
uniprot id: F4G109
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1006006:MCUP RS08450
gene id: 1006006:MCUP_RS08450
uniprot id: F4G0T3
names: Similarity
messages: Belongs to the PrpD family.

1006006:MCUP RS02300
gene id: 1006006:MCUP_RS02300
uniprot id: F4G058
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

1006006:MCUP RS00345
gene id: 1006006:MCUP_RS00345
uniprot id: F4FXX7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1006006:MCUP RS02170
gene id: 1006006:MCUP_RS02170
uniprot id: F4G032
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1006006:MCUP RS00090
gene id: 1006006:MCUP_RS00090
uniprot id: F4G3D0
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

1006006:MCUP RS01850
gene id: 1006006:MCUP_RS01850
uniprot id: F4FZP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1006006:MCUP RS05490
gene id: 1006006:MCUP_RS05490
uniprot id: F4G377
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

1006006:MCUP RS08460
gene id: 1006006:MCUP_RS08460
uniprot id: F4G0T5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1006006:MCUP RS00680
gene id: 1006006:MCUP_RS00680
uniprot id: F4FYC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1006006:MCUP RS01575
gene id: 1006006:MCUP_RS01575
uniprot id: F4FZA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1006006:MCUP RS09500
gene id: 1006006:MCUP_RS09500
uniprot id: F4G223
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS00255
gene id: 1006006:MCUP_RS00255
uniprot id: F4FXW1
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

1006006:MCUP RS01915
gene id: 1006006:MCUP_RS01915
uniprot id: F4FZQ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS02225
gene id: 1006006:MCUP_RS02225
uniprot id: F4G042
names: Similarity
messages: Belongs to the eIF-2-alpha family.

1006006:MCUP RS00745
gene id: 1006006:MCUP_RS00745
uniprot id: F4FYD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1006006:MCUP RS09325
gene id: 1006006:MCUP_RS09325
uniprot id: F4G1R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1006006:MCUP RS01525
gene id: 1006006:MCUP_RS01525
uniprot id: F4FZ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1006006:MCUP RS01270
gene id: 1006006:MCUP_RS01270
uniprot id: F4FYW7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1006006:MCUP RS02515
gene id: 1006006:MCUP_RS02515
uniprot id: F4G0A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1006006:MCUP RS09410
gene id: 1006006:MCUP_RS09410
uniprot id: F4G1S7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1006006:MCUP RS01025
gene id: 1006006:MCUP_RS01025
uniprot id: F4FYS1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1006006:MCUP RS05500
gene id: 1006006:MCUP_RS05500
uniprot id: F4G379
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1006006:MCUP RS01555
gene id: 1006006:MCUP_RS01555
uniprot id: F4FZA2
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1006006:MCUP RS02140
gene id: 1006006:MCUP_RS02140
uniprot id: F4FZU6
names: Similarity
messages: Belongs to the glutaredoxin family.

1006006:MCUP RS09585
gene id: 1006006:MCUP_RS09585
uniprot id: F4G236
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1006006:MCUP RS00960
gene id: 1006006:MCUP_RS00960
uniprot id: F4FYQ6
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1006006:MCUP RS02220
gene id: 1006006:MCUP_RS02220
uniprot id: F4G041
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1006006:MCUP RS00140
gene id: 1006006:MCUP_RS00140
uniprot id: F4G3D9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1006006:MCUP RS02270
gene id: 1006006:MCUP_RS02270
uniprot id: F4G052
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1006006:MCUP RS04090
gene id: 1006006:MCUP_RS04090
uniprot id: F4G266
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1006006:MCUP RS07275
gene id: 1006006:MCUP_RS07275
uniprot id: F4FZG1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1006006:MCUP RS08755
gene id: 1006006:MCUP_RS08755
uniprot id: F4G171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1006006:MCUP RS07170
gene id: 1006006:MCUP_RS07170
uniprot id: F4FZ58
names: Subunit
messages: Homodimer.

1006006:MCUP RS09020
gene id: 1006006:MCUP_RS09020
uniprot id: F4G1C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

1006006:MCUP RS01470
gene id: 1006006:MCUP_RS01470
uniprot id: F4FZ87
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1006006:MCUP RS01905
gene id: 1006006:MCUP_RS01905
uniprot id: F4FZQ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1006006:MCUP RS09255
gene id: 1006006:MCUP_RS09255
uniprot id: F4G1P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1006006:MCUP RS06145
gene id: 1006006:MCUP_RS06145
uniprot id: F4FY38
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1006006:MCUP RS06935
gene id: 1006006:MCUP_RS06935
uniprot id: F4FZ13
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1006006:MCUP RS08910
gene id: 1006006:MCUP_RS08910
uniprot id: F4G1A3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1006006:MCUP RS01460
gene id: 1006006:MCUP_RS01460
uniprot id: F4FZ85
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1006006:MCUP RS06720
gene id: 1006006:MCUP_RS06720
uniprot id: F4FYN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1006006:MCUP RS08470
gene id: 1006006:MCUP_RS08470
uniprot id: F4G0T8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1006006:MCUP RS06820
gene id: 1006006:MCUP_RS06820
uniprot id: F4FYY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.
messages: Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.
messages: Cytoplasm
messages: Monomer.

1006006:MCUP RS09535
gene id: 1006006:MCUP_RS09535
uniprot id: F4G227
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

1006006:MCUP RS07045
gene id: 1006006:MCUP_RS07045
uniprot id: F4FZ34
names: Similarity
messages: Belongs to the glutamine synthetase family.

1006006:MCUP RS01090
gene id: 1006006:MCUP_RS01090
uniprot id: F4FYT4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

1006006:MCUP RS06275
gene id: 1006006:MCUP_RS06275
uniprot id: F4FY71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1006006:MCUP RS03125
gene id: 1006006:MCUP_RS03125
uniprot id: F4G125
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1006006:MCUP RS04610
gene id: 1006006:MCUP_RS04610
uniprot id: F4G2H5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.
messages: In the C-terminal section; belongs to the urease beta subunit family.
messages: In the N-terminal section; belongs to the urease gamma subunit family.

1006006:MCUP RS02755
gene id: 1006006:MCUP_RS02755
uniprot id: F4G0M7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS02460
gene id: 1006006:MCUP_RS02460
uniprot id: F4G090
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1006006:MCUP RS00220
gene id: 1006006:MCUP_RS00220
uniprot id: F4FXV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS01885
gene id: 1006006:MCUP_RS01885
uniprot id: F4FZP7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1006006:MCUP RS08435
gene id: 1006006:MCUP_RS08435
uniprot id: F4G0T0
names: Similarity
messages: Belongs to the citrate synthase family.

1006006:MCUP RS06985
gene id: 1006006:MCUP_RS06985
uniprot id: F4FZ23
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1006006:MCUP RS06315
gene id: 1006006:MCUP_RS06315
uniprot id: F4FY81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

1006006:MCUP RS06760
gene id: 1006006:MCUP_RS06760
uniprot id: F4FYP5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1006006:MCUP RS00595
gene id: 1006006:MCUP_RS00595
uniprot id: F4FYA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1006006:MCUP RS04895
gene id: 1006006:MCUP_RS04895
uniprot id: F4G2P2
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

1006006:MCUP RS08480
gene id: 1006006:MCUP_RS08480
uniprot id: F4G0U0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1006006:MCUP RS00470
gene id: 1006006:MCUP_RS00470
uniprot id: F4FY01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

1006006:MCUP RS00095
gene id: 1006006:MCUP_RS00095
uniprot id: F4G3D1
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

1006006:MCUP RS01455
gene id: 1006006:MCUP_RS01455
uniprot id: F4FZ84
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

1006006:MCUP RS05830
gene id: 1006006:MCUP_RS05830
uniprot id: F4G3H7
names: Similarity
messages: Belongs to the HerA family.

1006006:MCUP RS07335
gene id: 1006006:MCUP_RS07335
uniprot id: F4FZH4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS07945
gene id: 1006006:MCUP_RS07945
uniprot id: F4G027
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS01515
gene id: 1006006:MCUP_RS01515
uniprot id: F4FZ95
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS02645
gene id: 1006006:MCUP_RS02645
uniprot id: F4G0K6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1006006:MCUP RS09310
gene id: 1006006:MCUP_RS09310
uniprot id: F4G1Q8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1006006:MCUP RS02745
gene id: 1006006:MCUP_RS02745
uniprot id: F4G0M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1006006:MCUP RS06370
gene id: 1006006:MCUP_RS06370
uniprot id: F4FY93
names: Similarity
messages: Belongs to the UPF0284 family.

1006006:MCUP RS04490
gene id: 1006006:MCUP_RS04490
uniprot id: F4G2E6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1006006:MCUP RS06595
gene id: 1006006:MCUP_RS06595
uniprot id: F4FYL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

1006006:MCUP RS00710
gene id: 1006006:MCUP_RS00710
uniprot id: F4FYC9
names: Similarity
messages: Belongs to the UPF0047 family.

1006006:MCUP RS06775
gene id: 1006006:MCUP_RS06775
uniprot id: F4FYP8
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS02775
gene id: 1006006:MCUP_RS02775
uniprot id: F4G0N1
names: Similarity
messages: Belongs to the TrpC family.

1006006:MCUP RS05155
gene id: 1006006:MCUP_RS05155
uniprot id: F4G2V7
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1006006:MCUP RS02115
gene id: 1006006:MCUP_RS02115
uniprot id: F4FZU1
names: Similarity
messages: Belongs to the EPSP synthase family.

1006006:MCUP RS07140
gene id: 1006006:MCUP_RS07140
uniprot id: F4FZ52
names: Similarity
messages: Belongs to the ZPR1 family.

1006006:MCUP RS01745
gene id: 1006006:MCUP_RS01745
uniprot id: F4FZD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1006006:MCUP RS00555
gene id: 1006006:MCUP_RS00555
uniprot id: F4FY97
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1006006:MCUP RS06140
gene id: 1006006:MCUP_RS06140
uniprot id: F4FY37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1006006:MCUP RS00725
gene id: 1006006:MCUP_RS00725
uniprot id: F4FYD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1006006:MCUP RS03735
gene id: 1006006:MCUP_RS03735
uniprot id: F4G1V1
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS00115
gene id: 1006006:MCUP_RS00115
uniprot id: F4G3D4
names: Similarity
messages: Belongs to the HTP reductase family.

1006006:MCUP RS09090
gene id: 1006006:MCUP_RS09090
uniprot id: F4G1D7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS06845
gene id: 1006006:MCUP_RS06845
uniprot id: F4FYZ2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1006006:MCUP RS01565
gene id: 1006006:MCUP_RS01565
uniprot id: F4FZA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1006006:MCUP RS01935
gene id: 1006006:MCUP_RS01935
uniprot id: F4FZQ7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1006006:MCUP RS00370
gene id: 1006006:MCUP_RS00370
uniprot id: F4FXY2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1006006:MCUP RS00080
gene id: 1006006:MCUP_RS00080
uniprot id: F4G3C8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1006006:MCUP RS01865
gene id: 1006006:MCUP_RS01865
uniprot id: F4FZP3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1006006:MCUP RS09435
gene id: 1006006:MCUP_RS09435
uniprot id: F4G1T1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1006006:MCUP RS00165
gene id: 1006006:MCUP_RS00165
uniprot id: F4FXU4
names: Similarity
messages: Belongs to the malic enzymes family.

1006006:MCUP RS05495
gene id: 1006006:MCUP_RS05495
uniprot id: F4G378
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

1006006:MCUP RS09405
gene id: 1006006:MCUP_RS09405
uniprot id: F4G1S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1006006:MCUP RS06805
gene id: 1006006:MCUP_RS06805
uniprot id: F4FYY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1006006:MCUP RS03130
gene id: 1006006:MCUP_RS03130
uniprot id: F4G126
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1006006:MCUP RS00760
gene id: 1006006:MCUP_RS00760
uniprot id: F4FYD9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1006006:MCUP RS00505
gene id: 1006006:MCUP_RS00505
uniprot id: F4FY09
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1006006:MCUP RS05850
gene id: 1006006:MCUP_RS05850
uniprot id: F4G3I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1006006:MCUP RS02080
gene id: 1006006:MCUP_RS02080
uniprot id: F4FZT4
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS00250
gene id: 1006006:MCUP_RS00250
uniprot id: F4FXW0
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1006006:MCUP RS08720
gene id: 1006006:MCUP_RS08720
uniprot id: F4G164
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1006006:MCUP RS06535
gene id: 1006006:MCUP_RS06535
uniprot id: F4FYK0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1006006:MCUP RS08990
gene id: 1006006:MCUP_RS08990
uniprot id: F4G1B7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS00340
gene id: 1006006:MCUP_RS00340
uniprot id: F4FXX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
messages: Homotetramer; dimer of dimers.

1006006:MCUP RS03090
gene id: 1006006:MCUP_RS03090
uniprot id: F4G118
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1006006:MCUP RS01275
gene id: 1006006:MCUP_RS01275
uniprot id: F4FYW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1006006:MCUP RS08035
gene id: 1006006:MCUP_RS08035
uniprot id: F4G0C0
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS05660
gene id: 1006006:MCUP_RS05660
uniprot id: F4G3E3
names: Similarity
messages: Belongs to the HypE family.

1006006:MCUP RS02760
gene id: 1006006:MCUP_RS02760
uniprot id: F4G0M8
names: Similarity
messages: Belongs to the TrpF family.

1006006:MCUP RS08175
gene id: 1006006:MCUP_RS08175
uniprot id: F4G0E8
names: Similarity
messages: Belongs to the UPF0237 family.

1006006:MCUP RS06335
gene id: 1006006:MCUP_RS06335
uniprot id: F4FY85
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS01610
gene id: 1006006:MCUP_RS01610
uniprot id: F4FZB2
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

1006006:MCUP RS08465
gene id: 1006006:MCUP_RS08465
uniprot id: F4G0T6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1006006:MCUP RS00570
gene id: 1006006:MCUP_RS00570
uniprot id: F4FYA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1006006:MCUP RS02025
gene id: 1006006:MCUP_RS02025
uniprot id: F4FZS4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1006006:MCUP RS01260
gene id: 1006006:MCUP_RS01260
uniprot id: F4FYW5
names: Subcellular Location Annotation
messages: Nucleus

1006006:MCUP RS03160
gene id: 1006006:MCUP_RS03160
uniprot id: F4G132
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1006006:MCUP RS02280
gene id: 1006006:MCUP_RS02280
uniprot id: F4G054
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1006006:MCUP RS00210
gene id: 1006006:MCUP_RS00210
uniprot id: F4FXV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS00135
gene id: 1006006:MCUP_RS00135
uniprot id: F4G3D8
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1006006:MCUP RS05875
gene id: 1006006:MCUP_RS05875
uniprot id: F4G3I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1006006:MCUP RS00145
gene id: 1006006:MCUP_RS00145
uniprot id: F4G3E0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1006006:MCUP RS08600
gene id: 1006006:MCUP_RS08600
uniprot id: F4G0W8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1006006:MCUP RS07465
gene id: 1006006:MCUP_RS07465
uniprot id: F4FZK0
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS06305
gene id: 1006006:MCUP_RS06305
uniprot id: F4FY78
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS08785
gene id: 1006006:MCUP_RS08785
uniprot id: F4G178
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1006006:MCUP RS03175
gene id: 1006006:MCUP_RS03175
uniprot id: F4G135
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS00855
gene id: 1006006:MCUP_RS00855
uniprot id: F4FYF5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1006006:MCUP RS00500
gene id: 1006006:MCUP_RS00500
uniprot id: F4FY08
names: Similarity
messages: Belongs to the SUI1 family.

1006006:MCUP RS00695
gene id: 1006006:MCUP_RS00695
uniprot id: F4FYC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

1006006:MCUP RS02155
gene id: 1006006:MCUP_RS02155
uniprot id: F4G029
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

1006006:MCUP RS09415
gene id: 1006006:MCUP_RS09415
uniprot id: F4G1S8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1006006:MCUP RS01880
gene id: 1006006:MCUP_RS01880
uniprot id: F4FZP6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1006006:MCUP RS01890
gene id: 1006006:MCUP_RS01890
uniprot id: F4FZP8
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1006006:MCUP RS08935
gene id: 1006006:MCUP_RS08935
uniprot id: F4G1A9
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS05265
gene id: 1006006:MCUP_RS05265
uniprot id: F4G310
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1006006:MCUP RS01140
gene id: 1006006:MCUP_RS01140
uniprot id: F4FYU5
names: Similarity
messages: Belongs to the DtxR/MntR family.

1006006:MCUP RS09260
gene id: 1006006:MCUP_RS09260
uniprot id: F4G1P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS09475
gene id: 1006006:MCUP_RS09475
uniprot id: F4G1T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1006006:MCUP RS02105
gene id: 1006006:MCUP_RS02105
uniprot id: F4FZT9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1006006:MCUP RS01560
gene id: 1006006:MCUP_RS01560
uniprot id: F4FZA3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1006006:MCUP RS00785
gene id: 1006006:MCUP_RS00785
uniprot id: F4FYE4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1006006:MCUP RS02485
gene id: 1006006:MCUP_RS02485
uniprot id: F4G095
names: Similarity
messages: Belongs to the CutA family.

1006006:MCUP RS07435
gene id: 1006006:MCUP_RS07435
uniprot id: F4FZJ4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

1006006:MCUP RS03900
gene id: 1006006:MCUP_RS03900
uniprot id: F4G1Y4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1006006:MCUP RS02110
gene id: 1006006:MCUP_RS02110
uniprot id: F4FZU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

1006006:MCUP RS02575
gene id: 1006006:MCUP_RS02575
uniprot id: F4G0J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1006006:MCUP RS09605
gene id: 1006006:MCUP_RS09605
uniprot id: F4G240
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1006006:MCUP RS03560
gene id: 1006006:MCUP_RS03560
uniprot id: F4G1I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1006006:MCUP RS03775
gene id: 1006006:MCUP_RS03775
uniprot id: F4G1V9
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS01595
gene id: 1006006:MCUP_RS01595
uniprot id: F4FZB0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS00390
gene id: 1006006:MCUP_RS00390
uniprot id: F4FXY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

1006006:MCUP RS01730
gene id: 1006006:MCUP_RS01730
uniprot id: F4FZD6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1006006:MCUP RS03625
gene id: 1006006:MCUP_RS03625
uniprot id: F4G1K5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1006006:MCUP RS00455
gene id: 1006006:MCUP_RS00455
uniprot id: F4FXZ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS01820
gene id: 1006006:MCUP_RS01820
uniprot id: F4FZN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS03230
gene id: 1006006:MCUP_RS03230
uniprot id: F4G146
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1006006:MCUP RS07010
gene id: 1006006:MCUP_RS07010
uniprot id: F4FZ27
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1006006:MCUP RS08650
gene id: 1006006:MCUP_RS08650
uniprot id: F4G0X9
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1006006:MCUP RS08790
gene id: 1006006:MCUP_RS08790
uniprot id: F4G179
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1006006:MCUP RS07380
gene id: 1006006:MCUP_RS07380
uniprot id: F4FZI3
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS05115
gene id: 1006006:MCUP_RS05115
uniprot id: F4G2U7
names: Similarity
messages: Belongs to the sterol desaturase family.

1006006:MCUP RS03035
gene id: 1006006:MCUP_RS03035
uniprot id: F4G107
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1006006:MCUP RS02730
gene id: 1006006:MCUP_RS02730
uniprot id: F4G0M2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1006006:MCUP RS04800
gene id: 1006006:MCUP_RS04800
uniprot id: F4G2L7
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS02580
gene id: 1006006:MCUP_RS02580
uniprot id: F4G0J4
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

1006006:MCUP RS09600
gene id: 1006006:MCUP_RS09600
uniprot id: F4G239
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1006006:MCUP RS01130
gene id: 1006006:MCUP_RS01130
uniprot id: F4FYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1006006:MCUP RS02700
gene id: 1006006:MCUP_RS02700
uniprot id: F4G0L6
names: Similarity
messages: Belongs to the aspartokinase family.

1006006:MCUP RS01440
gene id: 1006006:MCUP_RS01440
uniprot id: F4FZ81
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

1006006:MCUP RS01210
gene id: 1006006:MCUP_RS01210
uniprot id: F4FYV6
names: Similarity
messages: Belongs to the UPF0147 family.

1006006:MCUP RS08750
gene id: 1006006:MCUP_RS08750
uniprot id: F4G170
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1006006:MCUP RS06635
gene id: 1006006:MCUP_RS06635
uniprot id: F4FYM0
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS00350
gene id: 1006006:MCUP_RS00350
uniprot id: F4FXX8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

1006006:MCUP RS03030
gene id: 1006006:MCUP_RS03030
uniprot id: F4G106
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1006006:MCUP RS02210
gene id: 1006006:MCUP_RS02210
uniprot id: F4G039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1006006:MCUP RS02160
gene id: 1006006:MCUP_RS02160
uniprot id: F4G030
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1006006:MCUP RS02150
gene id: 1006006:MCUP_RS02150
uniprot id: F4G028
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1006006:MCUP RS00810
gene id: 1006006:MCUP_RS00810
uniprot id: F4FYE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1006006:MCUP RS02380
gene id: 1006006:MCUP_RS02380
uniprot id: F4G073
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS08765
gene id: 1006006:MCUP_RS08765
uniprot id: F4G173
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1006006:MCUP RS08575
gene id: 1006006:MCUP_RS08575
uniprot id: F4G0W3
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS02950
gene id: 1006006:MCUP_RS02950
uniprot id: F4G0Z1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1006006:MCUP RS08670
gene id: 1006006:MCUP_RS08670
uniprot id: F4G0Y2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1006006:MCUP RS00430
gene id: 1006006:MCUP_RS00430
uniprot id: F4FXZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1006006:MCUP RS02455
gene id: 1006006:MCUP_RS02455
uniprot id: F4G089
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

1006006:MCUP RS05510
gene id: 1006006:MCUP_RS05510
uniprot id: F4G381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1006006:MCUP RS03665
gene id: 1006006:MCUP_RS03665
uniprot id: F4G1L3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

1006006:MCUP RS02425
gene id: 1006006:MCUP_RS02425
uniprot id: F4G083
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1006006:MCUP RS04590
gene id: 1006006:MCUP_RS04590
uniprot id: F4G2H0
names: Similarity
messages: Belongs to the UreD family.

1006006:MCUP RS00175
gene id: 1006006:MCUP_RS00175
uniprot id: F4FXU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

1006006:MCUP RS01435
gene id: 1006006:MCUP_RS01435
uniprot id: F4FZ80
names: Similarity
messages: Belongs to the peptidase U62 family.

1006006:MCUP RS09565
gene id: 1006006:MCUP_RS09565
uniprot id: F4G232
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1006006:MCUP RS05840
gene id: 1006006:MCUP_RS05840
uniprot id: F4G3H9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS08445
gene id: 1006006:MCUP_RS08445
uniprot id: F4G0T2
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

1006006:MCUP RS08930
gene id: 1006006:MCUP_RS08930
uniprot id: F4G1A8
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1006006:MCUP RS00720
gene id: 1006006:MCUP_RS00720
uniprot id: F4FYD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1006006:MCUP RS02495
gene id: 1006006:MCUP_RS02495
uniprot id: F4G097
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1006006:MCUP RS05395
gene id: 1006006:MCUP_RS05395
uniprot id: F4G358
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1006006:MCUP RS03690
gene id: 1006006:MCUP_RS03690
uniprot id: F4G1L8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1006006:MCUP RS00275
gene id: 1006006:MCUP_RS00275
uniprot id: F4FXW5
names: Similarity
messages: Belongs to the HerA family.

1006006:MCUP RS09700
gene id: 1006006:MCUP_RS09700
uniprot id: F4G259
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1006006:MCUP RS06650
gene id: 1006006:MCUP_RS06650
uniprot id: F4FYM3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1006006:MCUP RS00045
gene id: 1006006:MCUP_RS00045
uniprot id: F4G3C2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1006006:MCUP RS00160
gene id: 1006006:MCUP_RS00160
uniprot id: F4FXU3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1006006:MCUP RS00360
gene id: 1006006:MCUP_RS00360
uniprot id: F4FXY0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1006006:MCUP RS00325
gene id: 1006006:MCUP_RS00325
uniprot id: F4FXX3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS06440
gene id: 1006006:MCUP_RS06440
uniprot id: F4FYI2
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

1006006:MCUP RS09400
gene id: 1006006:MCUP_RS09400
uniprot id: F4G1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1006006:MCUP RS08120
gene id: 1006006:MCUP_RS08120
uniprot id: F4G0D7
names: Similarity
messages: Belongs to the HerA family.

1006006:MCUP RS00215
gene id: 1006006:MCUP_RS00215
uniprot id: F4FXV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1006006:MCUP RS05620
gene id: 1006006:MCUP_RS05620
uniprot id: F4G3A5
names: Similarity
messages: Belongs to the thymidylate kinase family.

1006006:MCUP RS08995
gene id: 1006006:MCUP_RS08995
uniprot id: F4G1B8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

1006006:MCUP RS02415
gene id: 1006006:MCUP_RS02415
uniprot id: F4G080
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1006006:MCUP RS02610
gene id: 1006006:MCUP_RS02610
uniprot id: F4G0K0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1006006:MCUP RS04330
gene id: 1006006:MCUP_RS04330
uniprot id: F4G2B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1006006:MCUP RS07520
gene id: 1006006:MCUP_RS07520
uniprot id: F4FZL1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1006006:MCUP RS01810
gene id: 1006006:MCUP_RS01810
uniprot id: F4FZN2
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

1006006:MCUP RS01635
gene id: 1006006:MCUP_RS01635
uniprot id: F4FZB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1006006:MCUP RS06645
gene id: 1006006:MCUP_RS06645
uniprot id: F4FYM2
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

1006006:MCUP RS03070
gene id: 1006006:MCUP_RS03070
uniprot id: F4G114
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1006006:MCUP RS01030
gene id: 1006006:MCUP_RS01030
uniprot id: F4FYS2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1006006:MCUP RS04510
gene id: 1006006:MCUP_RS04510
uniprot id: F4G2F0
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS00805
gene id: 1006006:MCUP_RS00805
uniprot id: F4FYE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1006006:MCUP RS08550
gene id: 1006006:MCUP_RS08550
uniprot id: F4G0V7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1006006:MCUP RS09300
gene id: 1006006:MCUP_RS09300
uniprot id: F4G1Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS03165
gene id: 1006006:MCUP_RS03165
uniprot id: F4G133
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1006006:MCUP RS05440
gene id: 1006006:MCUP_RS05440
uniprot id: F4G367
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS05675
gene id: 1006006:MCUP_RS05675
uniprot id: F4G3E6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1006006:MCUP RS08305
gene id: 1006006:MCUP_RS08305
uniprot id: F4G0H4
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS09220
gene id: 1006006:MCUP_RS09220
uniprot id: F4G1N9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1006006:MCUP RS06860
gene id: 1006006:MCUP_RS06860
uniprot id: F4FYZ5
names: Similarity
messages: Belongs to the UPF0282 family.

1006006:MCUP RS09345
gene id: 1006006:MCUP_RS09345
uniprot id: F4G1R5
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1006006:MCUP RS08150
gene id: 1006006:MCUP_RS08150
uniprot id: F4G0E3
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS02145
gene id: 1006006:MCUP_RS02145
uniprot id: F4FZU7
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1006006:MCUP RS06215
gene id: 1006006:MCUP_RS06215
uniprot id: F4FY56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

1006006:MCUP RS03700
gene id: 1006006:MCUP_RS03700
uniprot id: F4G1U4
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1006006:MCUP RS06705
gene id: 1006006:MCUP_RS06705
uniprot id: F4FYN4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS08810
gene id: 1006006:MCUP_RS08810
uniprot id: F4G183
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS01420
gene id: 1006006:MCUP_RS01420
uniprot id: F4FZ77
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

1006006:MCUP RS09395
gene id: 1006006:MCUP_RS09395
uniprot id: F4G1S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

1006006:MCUP RS05185
gene id: 1006006:MCUP_RS05185
uniprot id: F4G2W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1006006:MCUP RS00450
gene id: 1006006:MCUP_RS00450
uniprot id: F4FXZ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1006006:MCUP RS00195
gene id: 1006006:MCUP_RS00195
uniprot id: F4FXV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1006006:MCUP RS09315
gene id: 1006006:MCUP_RS09315
uniprot id: F4G1Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1006006:MCUP RS02215
gene id: 1006006:MCUP_RS02215
uniprot id: F4G040
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1006006:MCUP RS09285
gene id: 1006006:MCUP_RS09285
uniprot id: F4G1Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS03055
gene id: 1006006:MCUP_RS03055
uniprot id: F4G111
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1006006:MCUP RS02050
gene id: 1006006:MCUP_RS02050
uniprot id: F4FZS8
names: Similarity
messages: Belongs to the glutamate synthase family.

1006006:MCUP RS05400
gene id: 1006006:MCUP_RS05400
uniprot id: F4G359
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1006006:MCUP RS07705
gene id: 1006006:MCUP_RS07705
uniprot id: F4FZX9
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1006006:MCUP RS06605
gene id: 1006006:MCUP_RS06605
uniprot id: F4FYL4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1006006:MCUP RS01500
gene id: 1006006:MCUP_RS01500
uniprot id: F4FZ92
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1006006:MCUP RS04060
gene id: 1006006:MCUP_RS04060
uniprot id: F4G219
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS03820
gene id: 1006006:MCUP_RS03820
uniprot id: F4G1W8
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1006006:MCUP RS02370
gene id: 1006006:MCUP_RS02370
uniprot id: F4G070
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
messages: Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.

1006006:MCUP RS00005
gene id: 1006006:MCUP_RS00005
uniprot id: F4G3B4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1006006:MCUP RS09460
gene id: 1006006:MCUP_RS09460
uniprot id: F4G1T6
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1006006:MCUP RS06625
gene id: 1006006:MCUP_RS06625
uniprot id: F4FYL8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1006006:MCUP RS06655
gene id: 1006006:MCUP_RS06655
uniprot id: F4FYM4
names: Caution
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS04065
gene id: 1006006:MCUP_RS04065
uniprot id: F4G220
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS01645
gene id: 1006006:MCUP_RS01645
uniprot id: F4FZB9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

1006006:MCUP RS09690
gene id: 1006006:MCUP_RS09690
uniprot id: F4G257
names: Subcellular Location Annotation
messages: Nucleus

1006006:MCUP RS04045
gene id: 1006006:MCUP_RS04045
uniprot id: F4G213
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1006006:MCUP RS09320
gene id: 1006006:MCUP_RS09320
uniprot id: F4G1R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1006006:MCUP RS00130
gene id: 1006006:MCUP_RS00130
uniprot id: F4G3D7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1006006:MCUP RS04025
gene id: 1006006:MCUP_RS04025
uniprot id: F4G210
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1006006:MCUP RS02595
gene id: 1006006:MCUP_RS02595
uniprot id: F4G0J7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1006006:MCUP RS01910
gene id: 1006006:MCUP_RS01910
uniprot id: F4FZQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1006006:MCUP RS05150
gene id: 1006006:MCUP_RS05150
uniprot id: F4G2V6
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS04100
gene id: 1006006:MCUP_RS04100
uniprot id: F4G268
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1006006:MCUP RS07910
gene id: 1006006:MCUP_RS07910
uniprot id: F4G020
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1006006:MCUP RS06980
gene id: 1006006:MCUP_RS06980
uniprot id: F4FZ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

1006006:MCUP RS01075
gene id: 1006006:MCUP_RS01075
uniprot id: F4FYT1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

1006006:MCUP RS09230
gene id: 1006006:MCUP_RS09230
uniprot id: F4G1P1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1006006:MCUP RS05820
gene id: 1006006:MCUP_RS05820
uniprot id: F4G3H5
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1006006:MCUP RS06735
gene id: 1006006:MCUP_RS06735
uniprot id: F4FYP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1006006:MCUP RS03975
gene id: 1006006:MCUP_RS03975
uniprot id: F4G1Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1006006:MCUP RS01295
gene id: 1006006:MCUP_RS01295
uniprot id: F4FYX2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1006006:MCUP RS08985
gene id: 1006006:MCUP_RS08985
uniprot id: F4G1B6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1006006:MCUP RS05280
gene id: 1006006:MCUP_RS05280
uniprot id: F4G313
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1006006:MCUP RS07375
gene id: 1006006:MCUP_RS07375
uniprot id: F4FZI2
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS09720
gene id: 1006006:MCUP_RS09720
uniprot id: F4G263
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1006006:MCUP RS09095
gene id: 1006006:MCUP_RS09095
uniprot id: F4G1D8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1006006:MCUP RS01985
gene id: 1006006:MCUP_RS01985
uniprot id: F4FZR6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

1006006:MCUP RS06380
gene id: 1006006:MCUP_RS06380
uniprot id: F4FY95
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1006006:MCUP RS06165
gene id: 1006006:MCUP_RS06165
uniprot id: F4FY43
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1006006:MCUP RS01665
gene id: 1006006:MCUP_RS01665
uniprot id: F4FZC3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS01750
gene id: 1006006:MCUP_RS01750
uniprot id: F4FZM0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1006006:MCUP RS04755
gene id: 1006006:MCUP_RS04755
uniprot id: F4G2K8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1006006:MCUP RS02410
gene id: 1006006:MCUP_RS02410
uniprot id: F4G079
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1006006:MCUP RS01390
gene id: 1006006:MCUP_RS01390
uniprot id: F4FZ71
names: Similarity
messages: Belongs to the DtxR/MntR family.

1006006:MCUP RS00460
gene id: 1006006:MCUP_RS00460
uniprot id: F4FXZ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1006006:MCUP RS09265
gene id: 1006006:MCUP_RS09265
uniprot id: F4G1P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1006006:MCUP RS07485
gene id: 1006006:MCUP_RS07485
uniprot id: F4FZK4
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

1006006:MCUP RS05825
gene id: 1006006:MCUP_RS05825
uniprot id: F4G3H6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1006006:MCUP RS08265
gene id: 1006006:MCUP_RS08265
uniprot id: F4G0G6
names: Subcellular Location Annotation
messages: Membrane

1006006:MCUP RS00750
gene id: 1006006:MCUP_RS00750
uniprot id: F4FYD7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1006006:MCUP RS00380
gene id: 1006006:MCUP_RS00380
uniprot id: F4FXY4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

1006006:MCUP RS09240
gene id: 1006006:MCUP_RS09240
uniprot id: F4G1P3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1006006:MCUP RS03080
gene id: 1006006:MCUP_RS03080
uniprot id: F4G116
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1006006:MCUP RS08830
gene id: 1006006:MCUP_RS08830
uniprot id: F4G187
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

1006006:MCUP RS08820
gene id: 1006006:MCUP_RS08820
uniprot id: F4G185
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1006006:MCUP RS08845
gene id: 1006006:MCUP_RS08845
uniprot id: F4G190
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1006006:MCUP RS02780
gene id: 1006006:MCUP_RS02780
uniprot id: F4G0N2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1006006:MCUP RS08200
gene id: 1006006:MCUP_RS08200
uniprot id: F4G0F3
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.