Mycobacterium tuberculosis H37Rv, complete genome.
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Submitted (06-FEB-2013) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (18-DEC-2012) Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND
REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence is identical to AL123456.\nOn Feb 6, 2013 this sequence version replaced NC_000962.2.\nRefSeq Category: Reference Genome\n FGS: First Genome sequenced\n MOD: Model Organism\n TYS: Designated Type Strain\n UPR: UniProt Genome\nNote:\nThis annotation is from the TubercuList website, Release 26, Dec\n2012 (URL: http://tuberculist.epfl.ch) (email:\ntuberculist@epfl.ch).\nCOMPLETENESS: full length.
DESCRIPTION:Mutation analysis, gene expression[PMID: 10375628]
EXISTENCE:Mass spectrometry[PMID:15525680]
EXISTENCE:Mass spectrometry[PMID:21085642]
EXISTENCE:Mass spectrometry[PMID:21920479]
chromosomal replication initiator protein DnaA
EXISTENCE:Mass spectrometry[PMID:20429878]
DESCRIPTION:Mutation analysis[PMID:8031045]
Belongs to the type II topoisomerase family.
COORDINATES:Mass spectrometry[PMID:21969609]
DESCRIPTION:Mass spectrometry[PMID:21920479]
A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004 PMID:14766927).
ileT, tRNA-Ile, anticodon gat, length = 74
alaT, tRNA-Ala, anticodon tgc, length = 73
DESCRIPTION:Gene expression, protein purification and characterization[PMID:23002219]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:15479239]
alternate gene name: cfp22; belongs to the cyclophilin-type PPIase family.
iron-regulated peptidyl-prolyl cis-trans isomerase PpiA
A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
DESCRIPTION:Gene expression, mutation analysis, protein localization[PMID:21531798]
EXISTENCE:Mass spectrometry[PMID:17443846]
glutamine amidotransferase; note that previously known as pabA.
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:21423706]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:10531215]
DESCRIPTION:Protein purification and characterization[PMID:21829358]
Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation on serine/threonine residues. PknB has been shown to be a substrate for PstP and its kinase activity is affected by PstP-mediated dephosphorylation. PknB and PstP (Rv0018c) may act as a functional pair in vivo to control mycobacterial cell growth.
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11856348]
Belongs to the Ser/Thr family of protein kinases. It has been shown that sodium orthovanadate inhibits the activity of the enzyme in vitro.
DESCRIPTION:Gene expression, protein purification and characterization[PMID:16436437]
DESCRIPTION:Mutation analysis, gene expression, protein purification and characterization[PMID:12950916]
Experimental studies have shown that PstP specifically dephosporylates model phospho-Ser/Thr substrates and it is likely that PknB (Rv0014c) and PstP may act as a functional pair in vivo to control mycobacterial cell growth.
phosphoserine/threonine phosphatase PstP
101 bp Mycobacterial Interspersed Repetitive Unit,Class I. See Supply et al. (1997) Molecular Microbiology 26, 991-1003
DESCRIPTION:Gene expression, mutation analysis, protein localization[PMID:20066037]
leuT, tRNA-Leu, anticodon cag, length = 83
DESCRIPTION:Gene expression, mutation analysis[PMID:22733573]
alternate gene name: whmG, WhiB-like regulatory protein.
member of major facilitator superfamily (MFS) possibly involved in transport of macrolide; integral membrane protein
A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927); secreted antigen
leucyl-tRNA synthetase LeuS; Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family.
DESCRIPTION:Gene expression[PMID:10448034]
Myo-inositol 1-phosphate synthase (MI-1-P synthase) (MIP synthase)
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11802794]
DESCRIPTION:Protein expression and characterization[PMID:20686708]
penicillin-binding protein 1A/1B; penicillin-binding protein (class A), bienzymatic protein with transglycosylase and transpeptidase activities
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase
DESCRIPTION:Protein purification and characterization[PMID:10491108]
Contains an intein (position 61630..62838). This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. In the intein section; belongs to the homing endonuclease family.
belongs to cellulase family B (family 6 of glycosyl hydrolases)
part of toxin-antitoxin (TA) operon with Rv0065
DESCRIPTION:Protein purification and characterization[PMID:22539524]
toxin, part of toxin-antitoxin (TA) operon with Rv0064A
Belongs to the monomeric-type family of IDH. Note that in H37Rv
Belongs to the iron-sulfur dependent L-serine dehydratase family.
DESCRIPTION:Protein purification and characterization[PMID:12913008]
Belongs to the ShmT family. Cofactor: pyridoxal phosphate.
group II intron maturase family. Contains 5 VDP repeats at N-terminus.
(MTV030.15), len: 315 nt. Probable REP'-1 pseudogene fragment
EXISTENCE:Mass spectrometry[PMID:21969609]
glutamine ABC transporter ATP-binding protein
class-II pyridoxal-phosphate-dependent aminotransferases (MALY/PATB subfamily)
This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
possible vaccine candidate (See Zvi et al.,2008 PMID:8505592).
alternate gene name: hevD, formate hydrogenlyase,integral membrane protein, belongs to the complex I subunit 1 family.
belongs to NADH-ubiquinone/plastoquinone oxidoreductase chain 4L superfamily
belongs to the NADH-Ubiquinone/plastoquinone (complex I) superfamily
alternate gene name: hevE, formate hydrogenlyase, belongs to the complex I 49 kDa subunit family.
belongs to the SRPBCC ligand-binding domain superfamily
Belongs to the methyltransferase superfamily.
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Belongs to the cation transport ATPases family (E1-E2 ATPases), subfamily IB.
REP-2, len: 1503 nt. REP251, member of REP13E12 family.
EXISTENCE:Mass spectrometry[PMID:11271494]
DESCRIPTION:Protein purification and characterization[PMID:17524985]
type III, conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
Belongs to the ATP-dependent AMP-binding enzyme family.
Belongs to the L28P family of ribosomal proteins.
Belongs to the cation transport ATPases family (E1-E2 ATPases).
Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins
sedoheptulose-7-phosphate isomerase GmhA. Belongs to the sis family, LPCA subfamily. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
D-alpha,beta-D-heptose-1,7-biphosphate phosphatase GmhB. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase
D-alpha-D-heptose-7-phosphate kinase HddA
DESCRIPTION:Gene expression[PMID:1489419]
LysR family, involved in the resistance to organic hydroperoxides
oxidative stress response regulatory protein OxyS
Belongs to the GTP-binding elongation factor family, EF-G/EF-2 subfamily.
Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins
DESCRIPTION:Protein characterization[PMID:10658666]
DESCRIPTION:Protein purification and characterization[PMID:18505459]
53 bp Mycobacterial Interspersed Repetitive Unit,Class III (see Supply et al., 1997)
53 bp Mycobacterial Interspersed Repetitive Unit,Class II
DESCRIPTION:Gene expression and protein characterization[PMID:11940150]
DESCRIPTION:Mutation analysis[PMID:10200974]
DESCRIPTION:Mutation analysis[PMID:12010501]
fibronectin-binding protein C, secreted antigen 85c,mycolyl transferase 85C
diacylglycerol acyltransferase/mycolyltransferase Ag85C
DESCRIPTION:Protein purification and characterization[PMID:16963641]
F420-dependent glucose-6-phosphate dehydrogenase
peptide methionine sulfoxide reductase MsrA
S-adenosylmethionine-dependent methyltransferase
(NAD+) dependent; Belongs to the aldehyde dehydrogenases family
belongs to the short-chain dehydrogenases/reductases (SDR) family
short-chain type dehydrogenase/reductase
belongs to the zinc-containing alcohol dehydrogenase family, quinone oxidoreductase subfamily
Member of the Mycobacterium tuberculosis PE family
DESCRIPTION:Gene expression, protein purification and characterization[PMID:10986245]
DESCRIPTION:Protein purification and characterization[PMID:17584180]
MPtpB, potent and selective inhibitor is an isoxazole compound
catalytic part; Probable pntAa,first part of NAD(P) transhydrogenase subunit alpha
NAD(P) transhydrogenase subunit alpha PntAa
NAD(P) transhydrogenase subunit alpha PntAb
NAD(P) transhydrogenase subunit beta PntB
Belongs to the zinc-containing alcohol dehydrogenase family,class-I subfamily. Cofactor: zinc.
zinc-type alcohol dehydrogenase subunit E
belongs to the GntR family of transcriptional regulators.
39 bp direct repeat 1,AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG
39 bp direct repeat 2,AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG
EXISTENCE:Gene expression[PMID:16483748]
EXISTENCE:Gene expression[PMID:21169493]
DESCRIPTION:Mutation analysis, protein purification and characterization[PMID:18724363]
Belongs to the ATP-binding transport protein family (ABC transporters).
multidrug ABC transporter ATPase/permease
belongs to peptidase family M13 (zinc metalloprotease); also known as the neprilysin subfamily.
EXISTENCE:Mass spectrometry[PMID:14532352]
iron-regulated, alternate gene names: pckG and pck1
Double hotdog R-specific hydratase of unknown function
DESCRIPTION:Gene expression[PMID:15262939]
101 bp Mycobacterial Interspersed Repetitive Unit,class III
COORDINATES:Mass spectrometry[PMID:21030493]
Belongs to the TetR/AcrR family of transcriptional regulators.
Belongs to the ribonucleoside diphosphate reductase small chain family. Cofactor: iron, manganese
ribonucleoside-diphosphate reductase subunit beta NrdB
DESCRIPTION:Gene expression[PMID:16027371]
arabinofuranosyltransferase AftD. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
3-hydroxyacyl-thioester dehydratase HtdX
F6, putative small regulatory RNA (See Arnvig and Young, 2009; DiChiara et al., 2010). Alternate 3'-ends at positions 293641 and 293661.
Note that succinate dehydrogenase forms generally part of an enzyme complex containing four subunits: a flavoprotein (Rv0248c), an iron-sulfur (Rv0247c), and two hydrophobic anchor proteins (Rv0249c).
succinate dehydrogenase iron-sulfur subunit
succinate dehydrogenase flavoprotein subunit
succinate dehydrogenase membrane anchor subunit
Hsp (alternate gene name: hsp20, hrpA, acr2), heat-stress-induced ribosome-binding protein A. Belongs to the small heat shock protein (HSP20) family.
nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit, flavoprotein containing siroheme and a 2FE-2S iron-sulfur center. Cofactors: FAD; Iron; Siroheme.
nirD,nitrite reductase [NAD(P)H] small subunit
cobU,cobalamin biosynthesis protein including a cobinamide kinase and cobinamide phosphate guanylyltransferase.
bifunctional cobinamide kinase/cobinamide phosphate guanylyltransferase
Belongs to the COBB/COBQ family, COBQ subfamily.
Belongs to the nark/NASA family of transporters.
DESCRIPTION:Gene expression[PMID:9159528]
iron ABC transporter substrate-binding lipoprotein
part of toxin-antitoxin (TA) operon with Rv0277c
DESCRIPTION:Gene expression[PMID:10603390]
A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927). Predicted possible vaccine candidate (See Zvi et al.,2008).
ESX-3 secretion-associated protein EspG3
DESCRIPTION:Gene expression[PMID:10974545]
DESCRIPTION:Protein purification and characterization[PMID:23011806]
part of toxin-antitoxin (TA) operon with Rv0301. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv0300, contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
glycerophosphoryl diester phosphodiesterase GlpQ
glyU, tRNA-Gly, anticodon ccc, length = 71
Belongs to peptidase family C15 (thiol protease).
Belongs to the UDP-glucose/GDP-mannose dehydrogenases family.
DESCRIPTION:Gene expression[PMID:9084178]
alpha-D-glucose-1-phosphate thymidylyltransferase RmlA
glucose-1-phosphate thymidylyltransferase
Belongs to class-I of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.
DESCRIPTION:Gene expression, mutation analysis[PMID:15752203]
Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.
heat shock protein 70 (heat shock 70 kDa protein) (HSP70)
Cofactor: binds two zinc ions per monomer.
Belongs to the MerR family of transcriptional regulators.
heat shock protein transcriptional repressor HspR
Mg2+ transport transmembrane protein MgtE
Belongs to class II fructose-bisphosphate aldolase family. Cofactor: zinc.
carbon monoxyde dehydrogenase large subunit
carbon monoxyde dehydrogenase small subunit
carbon monoxyde dehydrogenase medium subunit
Could be a part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c, SECD|Rv2587c,SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 and SECY|Rv0732.
heat shock protein F84.1; endopeptidase ATP binding protein ClpB
Belongs to the LuxR/UhpA family of transcriptional regulators.
gar transformylase 2 (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase). Belongs to the PurK / PurT family. Cofactor: magnesium.
phosphoribosylglycinamide formyltransferase PurT
OSH sulfhydrylase. Belongs to the trans-sulfuration enzymes family.
EXISTENCE:Gene expression[PMID:15042094]
long-chain-fatty-acid--AMP ligase FadD30
DESCRIPTION:Gene expression, protein purification and characterization[PMID:17376702]
Belongs to the phosphate acetyltransferase and butyryltransferase family.
DESCRIPTION:Gene expression and protein characterization[PMID:11496007]
DESCRIPTION:Gene expression, mutation analysis[PMID:15186418]
DESCRIPTION:Gene expression, mutation analysis[PMID:19528288]
Belongs to the bacterial extracellular solute-binding protein family 3
mutator protein MutT, 7,8-dihydro-8-oxoguanine-triphosphatase (8-oxo-dGTPase) (dGTP pyrophosphohydrolase
thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase (TMP-PPASE) (thiamine-phosphate synthase)
thiamine biosynthesis oxidoreductase ThiO
phosphomethylpyrimidine kinase ThiD, HMP-phosphate kinase (HMP-P kinase)
hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
exonuclease III (EXO III) (AP endonuclease VI) Belongs to the AP/EXOA family of DNA repair enzymes.
DESCRIPTION:Protein purification and characterization[PMID:15155722]
PS synthase (phosphatidylserine synthase). Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
CDP-diacylglycerol--serine O-phosphatidyltransferase
EXISTENCE:Protein crystalography[PMID:15547284]
60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (antigen A). Purified 65 kDa antigen can elicit a strong delayed-type hypersensitivity reaction in experimental animals infected with M. tuberculosis. This protein is one of the major immunoreactive proteins of the mycobacteria. This antigen contains epitopes that are common to various species of mycobacteria.
DESCRIPTION:Gene expression, mutation analysis[PMID:17064366]
cyclopropane-fatty-acyl-phospholipid synthase UfaA
part of toxin-antitoxin (TA) operon with Rv0456B
part of toxin-antitoxin (TA) operon with Rv0456A
3 copies of a 10 bp near-perfect direct repeat,ATTACTACCTATTACTACGTATTACTATCT
DESCRIPTION:Gene expression, mutation analysis[PMID:21238944]
DESCRIPTION:Gene expression, protein characterization[PMID:11560483]
DESCRIPTION:Mutation analysis, protein characterization[PMID:16093239]
Belongs to the pyridine nucleotide-disulfide oxidoreductases class-I
DESCRIPTION:Gene expression, protein purification and characterization[PMID:10932251]
DESCRIPTION:Mutation analysis[PMID:15895072]
DESCRIPTION:Protein purification and characterization[PMID:20378648]
beta-hydroxybutyryl-CoA dehydrogenase (BHBD)
DESCRIPTION:Gene expression[PMID:7604045]
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:22621931]
DESCRIPTION:Gene expression, mutation analysis[PMID:10882107]
DESCRIPTION:Gene expression, protein characterization[PMID:9770536]
iron-regulated adhesin A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
phosphodeoxyriboaldolase (deoxyriboaldolase) Belongs to the DEOC/FBAB family of aldolases, DEOC subfamily.
UDP-N-acetylmuramate dehydrogenase Cofactor: FAD.
UDP-N-acetylenolpyruvoylglucosamine reductase
mcr19, fragment of putative small regulatory RNA (See DiChiara et al., 2010), cloned from M. bovis BCG~Pasteur; ends not mapped, 66-82 nt band detected by Northern blot in M. bovis BCG Pasteur.
DESCRIPTION:Mutation analysis[PMID:12754249]
D-inositol 3-phosphate glycosyltransferase
phosphoglyceromutase (PGAM) (BPG-dependent PGAM)
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
DESCRIPTION:Gene expression[PMID:11101667]
two component sensor histidine kinase SenX3
77 bp Mycobacterial Interspersed Repetitive Unit,Class I (see Supply et al., 1997)
response regulator protein (sensory transduction protein)
two component sensory transduction protein RegX
galactowaldenase (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) Cofactor: NAD
DESCRIPTION:Mutation analysis[PMID:11092877]
cyclopropane fatty acid synthase (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase)
PSP (O-phosphoserine phosphohydrolase) (pspase)
PBG (hydroxymethylbilane synthase) (HMBS) (pre-uroporphyrinogen synthase) Cofactor: covalently binds a dipyrromethane cofactor to which the porphobilinogen subunits are added.
alternate gene name: cysG, uroporphyrinogen III methylase (urogen III methylase) (SUMT) (urogen III methylase) (UROM)
porphobilinogen synthase (ALAD) (ALADH) Belongs to the ALADH family. Cofactor: zinc.
4-amino butyrate transport carrier (GAMA-aminobutyrate permease) Belongs to the amino acid permease family (APC family).
GSA (glutamate-1-semialdehyde aminotransferase) (GSA-at). Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.
glutamate-1-semialdehyde 2,1-aminomutase
51 bp Mycobacterial Interspersed Repetitive Unit,Class II
cytochrome C-type biogenesis protein CcdA
cytochrome C-type biogenesis protein CcsA
DESCRIPTION:Gene expression, protein characterization[PMID:10840036]
beta-ketoacyl-ACP synthase III (KAS III)
1,4-dihydroxy-2-naphthoate octaprenyltransferase
DESCRIPTION:Protein purification and characterization[PMID:22225784]
MTA phosphorylase. Belongs to the PNP/MTAP family 2 of phosphorylases
galactowaldenase (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
dolichol-phosphate sugar synthetase (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase)
OSB-CoA synthetase (O-succinylbenzoate-CoA synthase)
low-affinity inorganic phosphate transporter
DESCRIPTION:Protein purification and characterization[PMID:10840036]
naphthoate synthase MenB; dihydroxynaphthoic acid synthetase (DHNA synthetase)
toxin, part of toxin-antitoxin (TA) operon with Rv0550c, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv0549c
58 bp Mycobacterial Interspersed Repetitive Unit,Class III
cis,cis-muconate lactonizing enzyme (MLE)
menaquinone biosynthesis protein, including 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase and 2-oxoglutarate decarboxylase activities. Cofactor: thiamine pyrophosphate.
bifunctional 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase
DESCRIPTION:Gene expression, mutation analysis[PMID:19395496]
DESCRIPTION:Gene expression, protein characterization[PMID:10531370]
GDP-mannose-dependent alpha-mannosyltransferase
alternate gene name: menG, ubiquinone/menaquinone (2-heptaprenyl-1,4-naphthoquinone methyltransferase)
polyprenyl pyrophosphate synthetase Belongs to the FPP/GGPP synthetases family.
transmembrane protein heat shock protein
alternate gene names: gpsA, glyC, [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase)
tyrT, tRNA-Tyr, anticodon gta, length = 81
ribonucleoside-diphosphate reductase large subunit NrdZ
vitamin B12-dependent ribonucleoside-diphosphate reductase
DESCRIPTION:Gene expression, mutation analysis[PMID:18490451]
nicotinic acid phosphoribosyltransferase PncB2
Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of ala-, gly-rich proteins
part of toxin-antitoxin (TA) operon with Rv0582
toxin, part of toxin-antitoxin (TA) operon with Rv0581,contains PIN domain
DESCRIPTION:Gene expression[PMID:19027363]
HTH-type transcriptional regulator Mce2R
DESCRIPTION:Gene expression[PMID:22354968]
toxin, part of toxin-antitoxin (TA) operon with Rv0596c, contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
part of toxin-antitoxin (TA) operon with Rv0595c. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv00599c, contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
part of toxin-antitoxin (TA) operon with Rv0598c. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
DESCRIPTION:Protein purification and characterization[PMID:17434492]
two component DNA binding transcriptional regulator TcrA
123 bp imperfect direct repeat 2, 92/103 bp identical to first copy at 709425..709548, AGCCCCGGCTCGACGCGGCATAGGGTGGCCACCGTGGCCGAAGCGTTCCATGCGACCG TGCCGTGGCGAGGATCCCGGCCGAACATGGCCCATTGAACGAGGACGTCATCGCACGA CGCCTGC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
IS1536, len: 1384 nt. Partial copy of insertion sequence IS_1536. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
part of toxin-antitoxin (TA) operon with Rv0609. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv0608, contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
74 bp imperfect direct repeat 2, 64/73 bp identical to first copy at 706790..706863, CACAGCGGACACCACAAAGCCCGCCGCTGCCACCGGATCGTCGGAACGAAAATAGTCG TACCCGTGAGCCTCGC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
B55, putative small regulatory RNA (See Arnvig and Young, 2009). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
74 bp imperfect direct repeat 1, 64/73 bp identical to second copy at 703912..703985, CACATCGGACACGACGAAACCCGCCGCTGCCACCGGATCGTCGGAGCGGAAGTAGTCG TACCCGTCGGCCTCGC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
123 bp imperfect direct repeat 1, 92/103 bp identical to second copy at 701247..701369, AGCCTCGGCTGGCCGCGGCATAAGGTGGCCACCGTGGCCGAAGCGTTCGATGCGACCC AAGCCGTGGCGAGAATCCTGGCCGAACATGGCCCATTGAGCGAGGACGACATCGCACG ACGCCTGC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
79 bp imperfect direct repeat 1, 73/78 bp identical to second copy at 711624..711702, TAGGGTTCGGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGACGGACGTGAGCT GCTGTTCTTTTCGCTGCCCGG. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
part of toxin-antitoxin (TA) operon with Rv0617
DESCRIPTION:Gene expression[PMID:22539524]
toxin, part of toxin-antitoxin (TA) operon with Rv0616A, contains PIN domain
79 bp imperfect direct repeat 2, 73/78 bp identical to first copy at 709585..709663, TAGGGTTCTGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGATGGCCGTGACCT GCTGTTCTTTTCGCTGCCCGG
part of toxin-antitoxin (TA) operon with Rv0624
toxin, part of toxin-antitoxin (TA) operon with Rv0623, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv0627 Cofactor: Mg2+
toxin, part of toxin-antitoxin (TA) operon with Rv0626,contains PIN domain
exodeoxyribonuclease V alpha chain (exodeoxyribonuclease V polypeptide) Consists of three subunits; RECB|Rv0630c, RECC|Rv0631c and RECD.
exodeoxyribonuclease V beta chain(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease). Consists of three subunits; RECB, RECC|Rv0631c and recd|Rv0629c.
exodeoxyribonuclease V gamma chain(exodeoxyribonuclease V polypeptide). Consists of three subunits; RECB|Rv0630c,RECC and recd|Rv0629c.
enoyl hydrase (unsaturated acyl-CoA hydratase) (crotonase)
hydroxyacylglutathione hydrolase (GLX II). Cofactor: binds two zinc ions.
thrT, tRNA-Thr, anticodon ggt, length = 73
metT, tRNA-Met, anticodon cat, length = 74
rpmG2. Note that Mycobacterium tuberculosis has a second rpmG gene
(3R)-hydroxyacyl-ACP dehydratase subunit HadA
(3R)-hydroxyacyl-ACP dehydratase subunit HadB
(3R)-hydroxyacyl-ACP dehydratase subunit HadC
trpT, tRNA-Trp, anticodon cca, length = 73
transcription termination/antitermination protein NusG
DESCRIPTION:Gene expression, mutation analysis[PMID:18535659]
DESCRIPTION:Gene expression[PMID:8917504]
methyl mycolic acid synthase 4 (MMA4) (hydroxy mycolic acid synthase)
DESCRIPTION:Gene expression, mutation analysis[PMID:10852869]
methyl mycolic acid synthase 3 (MMA3) (hydroxy mycolic acid synthase)
DESCRIPTION:Gene expression, mutation analysis[PMID:12502719]
methyl mycolic acid synthase 2 (MMA2) (hydroxy mycolic acid synthase)
DESCRIPTION:Gene expression, protein purification and characterization[PMID:9092547]
methyl mycolic acid synthase 1 (MMA1) (hydroxy mycolic acid synthase)
malonyl CoA-acyl carrier protein transacylase
DESCRIPTION:Protein purification and characterization[PMID:20929460]
toxin, part of toxin-antitoxin (TA) operon with Rv0657c,contains PIN domain . This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
part of toxin-antitoxin (TA) operon with Rv0656c . This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
part of toxin-antitoxin (TA) operon with Rv0660c. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
part of toxin-antitoxin (TA) operon with Rv0659c. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv0662c,contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
part of toxin-antitoxin (TA) operon with Rv0661c . This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
aryl-sulfate sulphohydrolase (arylsulphatase) Belongs to the sulfatase family. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv0664,contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
DESCRIPTION: Mutation analysis[PMID:11146248]
DESCRIPTION:Gene expression, mutation analysis[PMID:8031050]
transcriptase beta chain (RNA polymerase beta subunit)
DNA-directed RNA polymerase subunit beta
RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit)
DNA-directed RNA polymerase subunit beta'
DESCRIPTION:Gene expression[PMID:10593963]
DESCRIPTION:Protein purification and characterization[PMID:20139604]
End (endodeoxyribonuclease IV) (apurinase). Belongs to the AP endonucleases family 2. Cofactor: binds 3 zinc ions.
DESCRIPTION:Mutation analysis[PMID:7928982]
EXISTENCE:Mass spectrometry[PMID:18629250]
mycofactocin biosynthesis transcriptional regulator MftR
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenases family.
mycofactocin system heme/flavin oxidoreductase MftD
mycofactocin system creatinine amidohydrolase family protein MftE
52 bp Mycobacterial Interspersed Repetitive Unit,Class II
mycofactocin biosynthesis glycosyltransferase MftF
49 bp Mycobacterial Interspersed Repetitive Unit,Class II
87 bp Mycobacterial Interspersed Repetitive Unit,Class III
54 bp Mycobacterial Interspersed Repetitive Unit,Class II
endopeptidase IV (signal peptide peptidase)
Belongs to the aldolase class II family, ARAD/FUCA subfamily. Cofactor: binds one zinc ion per molecule.
xylulokinase) (xylulose kinase) Belongs to the fucokinase / gluconokinase / glycerokinase / xylulokinase family.
Belongs to the SECE/SEC61-alpha family. Part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c,SECG|Rv1440 and SECY.
DESCRIPTION:Protein purification and characterization[PMID:10398370]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:19688379]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:20363127]
DESCRIPTION:Gene expression, mutation analysis[PMID:16199577]
Belongs to the sigma-70 factor family, ECF subfamily.
DESCRIPTION:Gene expression, mutation analysis[PMID:16552079]
DESCRIPTION:Protein purification and characterization[PMID:20184899]
IS1557'-1, len: 517 nt. Region similar to Insertion sequence IS1557 on MTCY373- (IS1557- 1st copy). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
part of toxin-antitoxin (TA) operon with Rv0749. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv0748,contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
Belongs to the aldehyde dehydrogenases family.
methylmalonate-semialdehyde dehydrogenase
Member of the Mycobacterium tuberculosis PPE protein family
thrV, tRNA-Thr, anticodon tgt, length = 72
DESCRIPTION:Mutation analysis[PMID:11454210]
two component system response transcriptional positive regulator PhoP
two component system response sensor kinase PhoR
DESCRIPTION:Gene expression, protein purification and characterization[PMID:10430874]
DESCRIPTION:Protein purification and characterization[PMID:11160374]
Cytochrome P450 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)
101 bp Mycobacterial Interspersed Repetitive Unit,Class I
GARS (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) (5'-phosphoribosylglycinamide synthetase)
bifunctional cephalosporin acylase/gamma-glutamyltranspeptidase
phosphoribosylaminoimidazole-succinocarboxamide synthase
FGAM synthase I. Belongs to type-1 glutamine amidotransferases.
phosphoribosylformylglycinamidine synthase
4 bp direct repeat: GAGG, at the right end of IS6110
IS6110-1, len: 1355 nt. Insertion sequence IS6110.
28 bp inverted repeat at the left end of IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC
similar to insertion sequence element IS986/IS6110 transposase; Putative transposase for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation, the sequence UUUUAAAG maybe responsible for such a frameshifting event (see McAdam et al., 1990).
28 bp inverted repeat at the right end of IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC
4 bp direct repeat: GAGG, at the left end of IS6110
insertion sequence element IS1547 transposase
IS1547-1, len: 1092 nt. Insertion sequence IS1547.
EXISTENCE:Protein crystalography[PMID:18997321]
GNAT (GCN5-like N-acetyltransferase) family
phosphoribosylformylglycinamidine synthase 2
DESCRIPTION:Gene expression, mutation analysis[PMID:16313172]
DESCRIPTION:Mutation analysis, protein purification and characterization[PMID:17059828]
Class III Cyclic nucleotide phosphodiesterase (cNMP PDE)
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
galactowaldenase (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase)
exopolysaccharide phosphotransferase CpsY
glutamine phosphoribosylpyrophosphate amidotransferase (ATASE) (gpatase)
AIRS (phosphoribosyl-aminoimidazole synthetase) (air synthase)
phosphoribosylformylglycinamidine cyclo-ligase PurM
EXISTENCE:Protein crystalography[PMID:17172346]
rhodanese-like protein (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
DESCRIPTION:Gene expression[PMID:12375100]
acetyltransferase involved in mycothiol synthesis
phosphate ABC transporter ATP-binding protein PhoT
phosphate-transport system transcriptional regulator PhoY2
acyl-[ACP] desaturase (stearoyl-ACP desaturase) (protein Des). Belongs to the fatty acid desaturase family. Cofactor: ferredoxin, ferredoxin NADPH reductase,and NADPH.
ASdes, putative small regulatory RNA (See Arnvig and Young, 2009). Alternate 5'-ends at positions 918350 and 918365. Alternate 3'-ends at positions 918432 and 918412.
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:17726022]
IS1605', len: 288 nt. Insertion sequence IS1605'.
lysT, tRNA-Lys, anticodon ttt, length = 73
gluT, tRNA-Glu, anticodon ttc, length = 74
aspT, tRNA-Asp, anticodon gtc, length = 74
pheU, tRNA-Phe, anticodon gaa, length = 74
Pip (prolyl aminopeptidase) (pap). Belongs to peptidase family S33.
nitrate/nitrite response transcriptional regulator NarL
O-acetylserine sulfhydrylase (O-acetylserine (thiol)-lyase) (CSASE). Belongs to the cysteine synthase/cystathionine beta-synthase family. Cofactor: pyridoxal phosphate.
IS1606', len: 331 nt. Insertion sequence IS1606'
DESCRIPTION:Gene expression, protein purification and characterization[PMID:18086676]
EXISTENCE:Protein crystalography[PMID:17292400]
N-succinyldiaminopimelate aminotransferase DapC
55 bp Mycobacterial Interspersed Repetitive Unit,Class II
EXISTENCE:Protein crystalography[PMID:22684071]
molybdenum cofactor biosynthesis protein MoaC
cyclic pyranopterin monophosphate synthase accessory protein
molybdenum cofactor biosynthesis protein MoaE; molybdopterin converting factor large subunit (molybdopterin [MPT] converting factor, subunit 2)
molybdopterin synthase catalytic subunit 2
DESCRIPTION:Gene expression, mutation analysis[PMID:15207486]
DESCRIPTION:Mutation analysis[PMID:18186793]
molybdenum cofactor biosynthesis protein MoaD; molybdopterin converting factor small subunit (molybdopterin [MPT] converting factor, subunit 1)
cyclic pyranopterin monophosphate synthase
molybdenum cofactor biosynthesis protein MoaA
DESCRIPTION:Gene expression, protein purification and characterization[PMID:22525753]
Belongs to class-V of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.
adrenodoxin reductase (AR) (ferredoxin-NADP(+) reductase)
triacylglycerol synthase, diacylglycerol acyltransferase This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
DESCRIPTION:Gene expression[PMID:9657995]
DESCRIPTION:Protein purification and characterization[PMID:22108166]
outer membrane protein OmpA; Pore-forming activity is pH-dependent.
DESCRIPTION:Gene expression[PMID:11953357]
two component sensor histidine kinase PrrB
two component transcriptional regulator PrrA
acetyl-CoAcarboxylase carboxyl transferase subunit beta
lipid carrier protein or keto acyl-CoA thiolase
glycine betaine transport integral membrane protein BetP
argT, tRNA-Arg, anticodon cct, length = 73
IS1554, len: 1436 nt. Putative Insertion sequence element bounded by 15 bp inverted repeats.
15 bp inverted repeat, ATTCGGTGTAAGTGG, at the left end of IS1554 element
15 bp inverted repeat, ATTCGGTGTAAGTGG, at the right end of IS1554 element
IS1535, len: 2300 nt. Putative Insertion sequence element bounded by 16 bp inverted repeats.
16 bp inverted repeat, TTGAGTGTGTTTTAGT, at the left end of IS element IS1535
16 bp inverted repeat, TTGAGTGTGTTTTAGT, at the right end of IS element IS1535
DESCRIPTION:Gene expression[PMID:10477555]
integral membrane protein, alternative gene name: Nramp, Mramp, H+-dependent divalent cation-transport integral membrane protein
previously known as phoS2, phosphate-binding lipoprotein component of inorganic phosphate transport system
phosphate ABC transporter substrate-binding lipoprotein PstS
DESCRIPTION:Gene expression, mutation analysis[PMID:17411339]
DESCRIPTION:Protein purification and characterization[PMID:9119030]
alternate gene name: mbk (protein kinase D) (STPK D). Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2.
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11567022]
phosphate ABC transporter ATP-binding protein PstB
DESCRIPTION:Protein purification and characterization[PMID:15499016]
ATP dependent polydeoxyribonucleotide synthase (thermostable DNA ligase) (ATP dependent polynucleotide ligase) (sealase) (DNA repair enzyme) (DNA joinase)
multifunctional non-homologous end joining DNA repair protein/ATP dependent DNA ligase LigD
bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase/cyclase/dehydrase
DESCRIPTION:Protein purification and characterization[PMID:20031487]
GPI (phosphoglucose isomerase) (phosphohexose isomerase) (phi)
DESCRIPTION:Gene expression[PMID:17965159]
DESCRIPTION:Protein purification and characterization[PMID:18727669]
DESCRIPTION:Protein purification and characterization[PMID:17158674]
EXISTENCE:Protein crystalography[PMID:19394344]
GART (gar transformylase) (5'-phosphoribosylglycinamide transformylase)
phosphoribosylglycinamide formyltransferase PurN
PurH, bifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase and inosine-monophosphate (imp) cyclohydrolase
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosinemonophosphate cyclohydrolase
part of toxin-antitoxin (TA) operon with Rv0960
toxin, part of toxin-antitoxin (TA) operon with Rv0959A,contains PIN domain
DESCRIPTION:Gene expression, protein purification and characterization[PMID:17143269]
copper-sensing transcriptional repressor CsoR
DESCRIPTION:Gene expression, mutation analysis[PMID:20624225]
DESCRIPTION:Gene expression[PMID:9535763]
alternate gene name: bccA AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
acetyl/propionyl-CoA carboxylase subuit alpha
acetyl-/propionyl-CoA carboxylase subunit beta
DESCRIPTION:Gene expression, protein purification and characterization[PMID:14638785]
DESCRIPTION:Mutation analysis[PMID:11675502]
mycobacterial persistence regulator whose expression is required for entrance into and maintenance of persistent infection. MprAB is involved in the regulation of genes in response to environmental stress
MprAB is involved in the regulation of genes in response to environmental stress
two component histidine-protein kinase/phosphatase MprB
PHS (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD)
pterin-4-alpha-carbinolamine dehydratase
large-conductance ion mechanosensitive channel
adhesion component ABC transporter ATP-binding protein
adhesion component ABC transporter permease
UDP-glucose pyrophosphorylase (UDPGP) (alpha-D-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase)
UTP--glucose-1-phosphate uridylyltransferase
acetylating enzyme for N-terminal of ribosomal protein S5
ribosomal-protein-alanine acetyltransferase RimJ
alaV, tRNA-Ala, anticodon cgc, length = 73
dolichyl-phosphate-mannose--protein mannosyltransferase
DESCRIPTION:Protein purification and characterization[PMID:9607323]
MetRS (methionyl-tRNA synthetase MetS) metS (MetG)
DESCRIPTION:Mutation analysis[PMID:14688133]
dimethyladenosine transferase KsgA; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
CMK (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase). Belongs to the ISPE family.
4-diphosphocytidyl-2C-methyl-D-erythritol kinase
50S ribosomal protein L25/general stress protein Ctc
phosphoribosyl pyrophosphate synthetase (PRPP synthetase). Belongs to the ribose-phosphate pyrophosphokinase family. Cofactor: both inorganic phosphate and magnesium ion are required for enzyme stability and activity (by similarity).
EXISTENCE:Protein crystalography[PMID:19237750]
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase
glnT, tRNA-Gln, anticodon ttg, length = 72
DESCRIPTION:Protein purification and characterization[PMID:20529853]
nucleoside triphosphate pyrophosphohydrolase
Belongs to universal stress protein family.
potassium-translocating ATPase a chain (ATP phosphohydrolase [potassium-transporting] a chain) (potassium binding and translocating subunit A)
potassium-translocating ATPase B chain (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B)
potassium-translocating ATPase C chain (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C)
DESCRIPTION:Gene expression[PMID:10089160]
Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+ or Ca2+ as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.
two component sensor histidine kinase TrcS
Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.
two component transcriptional regulator TrcR
IS1560-1, len: 1513 nt. Insertion sequence IS1560.
IS-LIKE-1, len: 978 nt. Insertion sequence, ISLIKE,region. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
18 bp inverted repeat at the left end of IS-LIKE element, CTAGGGCGTGTCTCCCAA. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
18 bp inverted repeat at the right end of a IS-LIKE element, CTAGGGCGTGTCTCCCAA. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
IS1081-1, len: 1435 nt. Insertion sequence IS1081. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
mpr5, fragment of putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, 100 nt band detected by Northern blot.
leuX, tRNA-Leu, anticodon taa, length = 74. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
fatty-acid-CoA synthetase (fatty-acid-CoA synthase)
Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450)
DESCRIPTION:Protein purification and characterization[PMID:19428471]
CGS (O-succinylhomoserine [thiol]-lyase). Belongs to the trans-sulfuration enzymes family.
DESCRIPTION:Gene expression, protein characterization[PMID:10978158]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:10816587]
Short (C15) chain Z-FPP synthase (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase)
MTS0858, putative small regulatory RNA (See Arnvig et al., 2011), ends not mapped, ~100 bp band detected by Northern blot.
EXISTENCE:Protein crystalography[PMID:15929999]
acyl-[ACP] desaturase (stearoyl-ACP desaturase)
phosphate starvation-inducible protein PsiH
DESCRIPTION:Gene expression[PMID:15470127]
DESCRIPTION:Gene expression and protein characterization[20705052]
toxin, part of toxin-antitoxin (TA) operon with Rv1103c
DESCRIPTION:Gene expression and protein characterization[19016878]
part of toxin-antitoxin (TA) operon with Rv1102c
DESCRIPTION:Gene expression, protein purification and characterization[PMID:17630785]
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
part of toxin-antitoxin (TA) operon with Rv1114
toxin, part of toxin-antitoxin (TA) operon with Rv1113,contains PIN domain
6-phosphogluconate dehydrogenase (decarboxylating)
REP-3, len: 1325 nt. REP22G8, member of REP13E12 family.
methionine synthase, vitamin-B12 independent isozyme
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase
Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase)
REP-4, len: 1348 nt. REP165, member of REP13E12 family.
IS-LIKE-2, len: 984 nt. Insertion sequence element IS-LIKE.
4 bp direct repeat, CTAG, generated by IS element on insertion. Proposed by Mariani et al. 1993. J. Gen. Microbiol., 139: 1767-1772. Note that as motif palindromic could be part of inverted repeat itself.
17 bp Inverted repeat at the left end of putative IS-LIKE-2 element : GGCGTGTCTCCCAAATT. Proposed by Mariani et al. 1993. J. Gen. Microbiol. 139: 1767-1772.
Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of putative Mycobacterium tuberculosis is element. The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08.
17 bp Inverted repeat at the right end of putative IS-LIKE-2 element :GGCGTGTCTCCCAATTT. Proposed by Mariani et al. 1993. J. Gen. Microbiol. 139: 1767-1772
4 bp direct repeat, CTAG generated by IS element on insertion. Proposed by Mariani et al. 1993. J. Gen. Microbiol. 139: 1767-1772. Note that as motif palindromic could be part of inverted repeat itself.
DESCRIPTION:Protein purification and characterization[PMID:19747094]
DESCRIPTION:Protein crystallograph[PMID:15620716]
DESCRIPTION:Protein crystallography and characterization[PMID:16239726]
pyridoxine/pyridoxamine 5'-phosphate oxidase
mcr10, putative small regulatory RNA (See DiChiara et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur, 3'-end not mapped, ~118 nt band detected by Northern blot.
Belongs to the GT-C superfamily of glycosyltransferases
polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase
4a-hydroxytetrahydrobiopterin dehydratase
DESCRIPTION:Gene expression, mutation analysis[PMID:16585780]
mutator protein MutT; 7,8-dihydro-8-oxoguanine-triphosphatase (8-oxo-dGTPase)
DESCRIPTION:Gene expression, mutation analysis[PMID:14645286]
tyrosine phosphorylated protein A (GTP-binding protein)
GTP-binding translation elongation factor
monoacyl phosphatidylinositol tetramannoside-binding protein LpqW
DESCRIPTION:Gene expression[PMID:11092856]
N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase MshB; GlcNAc-Ins deacetylase
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
62 bp direct repeat copy 1, GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCA ATCT
62 bp direct repeat copy 2, GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCA ATCT
62 bp direct repeat partial copy 3 (43/62 bp),GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGGGGCCCG
NADPH dependent 2,4-dienoyl-CoA reductase FadH
Rv1180/Rv1181 fusion has been called msl3. The two CDS's may represent separate modules of the polyketide synthase.
DESCRIPTION:Protein purification and characterization[PMID:19276083]
polyketide synthase associated protein PapA
fatty-acid-AMP synthetase (fatty-acid-AMP synthase)
pyrroline-5-carboxylate dehydrogenase RocA
ncrMT1234, fragment of putative small regulatory RNA (See Pelly et al., 2012), cloned from M. tuberculosis CDC1551; supported by RNA-seq in H37Rv (unpublished data).; Fragment of putative small regulatory RNA
insertion sequence element IS1081 transposase
IS1081-2, len: 1429 nt. Insertion sequence IS1081.
EXISTENCE:Protein crystalography[PMID:18765924]
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
succinyl-diaminopimelate desuccinylase DapE
DHPS 2 (dihydropteroate pyrophosphorylase 2)
EXISTENCE:Protein crystalography[PMID:19015727]
tag I (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I)
DESCRIPTION:Gene expression, mutation analysis[PMID:18808383]
ADP-glucose synthase (ADP-glucose pyrophosphorylase)
tetronasin ABC transporter integral membrane protein
tetronasin ABC transporter ATP-binding protein
DESCRIPTION:Gene expression[PMID:11373121]
DESCRIPTION:Mutation analysis[PMID:11489128]
alternative sigma factor of extracytoplasmic function (ECF) family
mpr6, fragment of putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, ~118 nt band detected by Northern blot in M. bovis BCG Pasteur.
DESCRIPTION:Protein purification and characterization[PMID:20025669]
Sec-independent protein translocase protein TatB
multiple resistance/pH adaptation protein
DESCRIPTION:Gene expression, mutation analysis[PMID:21118978]
trehalose ABC transporter substrate-binding lipoprotein LpqY
sugar ABC transporter ATP-binding protein SugC
magnesium and cobalt transport transmembrane protein CorA
part of toxin-antitoxin (TA) operon with Rv1242
toxin, part of toxin-antitoxin (TA) operon with Rv1241, contains PIN domain
EXISTENCE:Gene expression[PMID:19114484]
part of toxin-antitoxin (TA) operon with Rv1247c
part of toxin-antitoxin (TA) operon with Rv1246c
DESCRIPTION:Protein purification and characterization[PMID:16045627]
Multifunctional alpha-ketoglutarate metabolic enzyme. Cofactor: thiamine diphosphate.
multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase
cold-shock DeaD-box protein; DeaD (ATP-dependent RNA helicase dead homolog)
EXISTENCE:Protein crystalography[PMID:18089574]
DESCRIPTION:Gene expression[PMID:17005450]
DESCRIPTION:Mutation analysis[PMID:11839758]
DESCRIPTION:Mutation analysis[PMID:15890882]
ATP pyrophosphate-lyase (adenylate cyclase)The N terminus seems to be a potential novel regulator of adenylyl cyclase activity (autoinhibitory domain). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
mcr11, putative small regulatory RNA (See DiChiara et al., 2010). 5'-end mapped by RLM-RACE in M. tuberculosis H37Rv, 3'-end not mapped (See Arnvig et al., 2011).
DESCRIPTION:Gene expression, mutation analysis[PMID:14690440]
DESCRIPTION:Gene expression[PMID:15043876]
EXISTENCE:Gene expression[PMID:16585755]
EXISTENCE:Gene expression[PMID:16817899]
drug ABC transporter ATP-binding protein
oligopeptide ABC transporter substrate-binding lipoprotein OppA
oligopeptide ABC transporter ATP-binding protein OppD
oligopeptide ABC transporter permease OppC
oligopeptide ABC transporter permease OppB
DESCRIPTION:Protein purification and characterization[PMID:15753099]
DESCRIPTION:Protein purification and characterization[PMID:15184554]
Belongs to the PAPS reductase family. CYSD subfamily.
argV, tRNA-Arg, anticodon ccg, length = 73
DESCRIPTION:Gene expression[PMID:8440471]
DESCRIPTION:Protein crystallography[PMID:12637582]
DESCRIPTION:Protein purification and characterization[PMID:18621388]
release factor glutamine methyltransferase
43 bp Mycobacterial Interspersed Repetitive Unit,Class III
52 bp Mycobacterial Interspersed Repetitive Unit,Class III
DESCRIPTION:Gene expression[PMID:20637039]
decaprenyl-phosphate N-acetylglucosaminephosphotransferase
AtpB, F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein), F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
AtpF, F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
AtpH, F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
AtpA, F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
AtpG, F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
AtpD, F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
AtpC, F-type ATPases have 2 components, cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0) has three main subunits: A, B and C.
IS1557-2, len: 1509 nt. Insertion sequence IS1557.
19 bp inverted repeat, GCAGACGCAAAAGCCCCCA, at the left end of IS1557
insertion sequence element IS1557 transposase
19 bp inverted repeat, GCAGACGCGAAAGCCCCCA, at the right end of IS1557. Single base difference at 3-end.
cob(I)yrinic acid a,c-diamide adenosyltransferase
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
mcr3, putative small regulatory RNA (See DiChiara et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur, 3'-end not mapped.
rrs, 16s rRNA gene (alternate gene name: rrnS).
rrl, 23S rRNA gene (approximate coordinates).
rrf, 5S rRNA gene. Identical to Em_ba:MT5SRR, D10035 M.tuberculosis 5S rRNA, len: 116.
DESCRIPTION:Gene expression, mutation analysis[PMID:21570366]
Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase)
methylated-DNA--protein-cysteine methyltransferase
regulatory protein of adaptative response (methylphosphotriester-DNA--protein-cysteine S-methyltransferase)
bifunctional regulatory protein/DNA repair enzyme AlkA
ATP pyrophosphate-lyase (adenylyl cyclase)
DESCRIPTION:Protein purification and characterization[PMID:17005418]
alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
nicotinic acid phosphoribosyltransferase PncB1
ATP-dependent Clp protease adapter protein ClpS
DESCRIPTION:Protein purification and characterization[PMID:16104727]
DESCRIPTION:Gene expression, protein characterization[PMID:16104727]
DESCRIPTION:Gene expression, protein characterization[PMID:18842002]
cysteine synthase B, (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B)
non-canonical purine NTP pyrophosphatase
acyl-[acyl-carrier-protein] dehydrogenase MbtN
EXISTENCE:Protein crystalography[PMID:15695811]
leuW, tRNA-Leu, anticodon tag, length = 84
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:19948799]
DESCRIPTION:Gene expression, mutation analysis[PMID:16385031]
iron ABC transporter ATP-binding protein/permease IrtA
iron ABC transporter ATP-binding protein/permease IrtB
3-ketoacyl-acyl carrier protein reductase
EXISTENCE:Mass spectrometry[PMID:14595687]
Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
mcr15, putative small regulatory RNA (See DiChiara et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur, 3'-end not mapped.
DESCRIPTION:Gene expression, protein purification and characterization[PMID:12354223]
anti-sigma factor antagonist (regulator of sigma F A)
3 bp direct repeat, CGG, at 3' end of IS6110 target sequence
IS6110-2, len: 1355 nt. Almost identical to Insertion sequence IS986 element.
similar to insertion sequence element IS986/IS6110 transposase; Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation, the sequence UUUUAAAG maybe responsible for such a frameshifting event (see McAdam et al., 1990)
3 bp direct repeat, CGG, at 5' end of IS6110 target sequence
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:15286723]
alpha-pyrone synthesis polyketide synthase-like protein
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11882713]
MTS1082, putative small regulatory RNA (See Arnvig et al., 2011), ends not mapped, ~150 bp band detected by Northern blot.
bifunctional pyrimidine operon regulatory protein/uracil phosphoribosyltransferase
carbamoyl-phosphate synthetase glutamine chain
carbamoyl-phosphate synthase small subunit
carbamoyl-phosphate synthetase ammonia chain
carbamoyl-phosphate synthase large subunit
EXISTENCE: similar to sequence:UniProt:P96802
RpoZ (transcriptase omega chain) (RNA polymerase omega subunit)
DNA-directed RNA polymerase subunit omega
DNA/pantothenate metabolism flavoprotein; Coenzyme A biosynthesis
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
mat (AdoMet synthetase) (methionine adenosyltransferase)
DESCRIPTION:Gene expression, protein purification and characterization[PMID:12826660]
toxin, part of toxin-antitoxin (TA) operon with Rv1398c, contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
part of toxin-antitoxin (TA) operon with Rv1397c. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
DESCRIPTION:Protein purification and characterization[PMID:15373841]
Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase)
ribG (alternate gene name: ribD), bifunctional riboflavin biosynthesis protein, including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase
bifunctional riboflavin biosynthesis diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase
DESCRIPTION:Gene expression, mutation analysis[PMID:18156250]
aminoglycosides/tetracycline-transport integral membrane protein
bifunctional riboflavin biosynthesis GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase)
Member of the Mycobacterium tuberculosis PE family of proteins
21 bp imperfect direct repeat 5,GGCGCACCGGTACCGGTACCC
21 bp imperfect direct repeat 4,GGCGGACCGGTACCGATACCG
21 bp imperfect direct repeat 3,GGCGCACCGGTACCAATCCCC
21 bp imperfect direct repeat 2,GGCGCACCGGTACCGATACCG
21 bp imperfect direct repeat 1,GGCGCACCGGTACCAATCCCT
glyceraldehyde 3-phosphate dehydrogenase
1260 bp imperfect direct repeat 2, first copy at 1637133..1638392
1260 bp imperfect direct repeat 1, second copy at 1633531..1634790
NADPH:quinone reductase (zeta-crystallin homolog protein)
antibiotic ABC transporter ATP-binding protein
EXISTENCE:Gene expression[PMID:18452585]
macrolide ABC transporter ATP-binding protein
DESCRIPTION:Gene expression, protein purification and characterization[PMID:17919286]
DESCRIPTION:Mutation analysis, protein purification and characterization[PMID:20826344]
DESCRIPTION:Protein purification and characterization[PMID:21864539]
DESCRIPTION:Gene expression, mutation analysis[PMID:19685079]
DESCRIPTION:Protein purification and characterization[PMID:11932442]
3-ketoacyl-acyl carrier protein reductase (mycolic acid biosynthesis a protein)
DESCRIPTION:Gene expression, mutation analysis[PMID:18552191]
DESCRIPTION:Protein purification and characterization[PMID:7599116]
Probable mutA,Methylmalonyl-CoA mutase small-subunit
part of toxin-antitoxin (TA) operon with Rv1495
DESCRIPTION:Gene expression, protein purification and characterization[PMID:20724443]
toxin, part of toxin-antitoxin (TA) operon with Rv1494
DESCRIPTION:Gene expression, mutation analysis[PMID:18585090]
pol IV 1 (DNA nucleotidyltransferase (DNA-directed))
DESCRIPTION:Protein purification and characterization[PMID:10636862]
fumarate dehydrogenase (fumaric hydrogenase)
fumarate reductase membrane anchor subunit
part of toxin-antitoxin (TA) operon with Rv1561
toxin, part of toxin-antitoxin (TA) operon with Rv1560, contains PIN domain
DESCRIPTION:Gene expression, protein purification and characterization[PMID:10658666]
malto-oligosyltrehalose trehalohydrolase
adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA
AONS (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase)
ATP-dependent dethiobiotin synthetase BioD
12 bp direct repeat 1, ccacggccaacc, flanking phage-like element, second site at 1788514..1788525. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
89 bp direct repeat 2, first copy at 1780485..1780573, GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCCGGCGGAGATGCCGAGGGC TG CGCCGATAGCAGTGTCTGTTTTCGTCGAA. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
89 bp direct repeat 1, second copy at 1779959..1780047, GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCCGGCGGAGATGCCGAGGGC TG CGCCGATAGCAGTGTCTGTTTTCGTCGAA. Many repeats, both direct and inverted, in this region. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
REP-5, len: 1298 nt. REP336, member of REP13E12 family. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
12 bp direct repeat 2, ccacggccaacc, flanking phage-like element, first site at 1779266..1779277. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
imidazole glycerol-phosphate dehydratase
imidazole glycerol phosphate synthase subunit HisH
DESCRIPTION:Gene expression, mutation analysis[PMID:12634849]
phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase
DESCRIPTION:Gene expression, mutation analysis[PMID:20167072]
imidazole glycerol phosphate synthase subunit HisF
ionic transporter integral membrane protein ChaA
prolipoprotein diacylglyceryl transferase
DESCRIPTION:Protein purification and characterization[PMID:20520732]
transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome
cytochrome biosyntheisis ABC transporter ATP-binding protein/permease CydC
cytochrome biosyntheisis ABC transporter ATP-binding protein/permease CydD
cytochrome D ubiquinol oxidase subunit II CydB
cytochrome D ubiquinol oxidase subunit I CydA
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11447108]
DESCRIPTION:Protein purification and characterization[PMID:11431477]
Cya (ATP pyrophosphate-lyase) (adenylate cyclase)
leuV, tRNA-Leu, anticodon caa, length = 74
two-component system transcriptional regulator
DESCRIPTION:Gene expression, protein purification and characterization[PMID:9016652]
DESCRIPTION:Protein purification and characterization[PMID:20455546]
DESCRIPTION:Gene expression, mutation analysis[PMID:19649276]
Includes: Lysine--tRNA ligase (Lysyl-tRNA synthetase) (LysRS); Phosphatidylglycerol lysyltransferase (Lysylphosphatidylglycerol synthetase) (LPG synthetase)]
bifunctional lysine--tRNA ligase/phosphatidylglycerol lysyltransferase
EXISTENCE:Mass spectrometry[PMID:15952732]
phenylalanine--tRNA ligase subunit alpha
N-acetyl-gamma-glutamyl-phoshate reductase
DESCRIPTION:Protein purification and characterization[PMID:20184895]
Arginine biosynthesis bifunctional protein ArgJ [Includes: Glutamate N-acetyltransferase (Ornithine acetyltransferase) (OATase) (Ornithine transacetylase); Amino-acid acetyltransferase ~(N-acetylglutamate synthase) (AGSase)]
bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase
DESCRIPTION:Gene expression, mutation analysis[PMID:12730158]
56 bp direct repeat 1, AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT
56 bp direct repeat 2, AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT
bifunctional long-chain acyl-CoA synthase/lipase
G2, putative small regulatory RNA (See Arnvig and Young, 2009). Alternate 5'-end at position 1915028. Alternate 3'-end at position 1914977.
DESCRIPTION:Gene expression, mutation analysis[PMID:15673735]
DESCRIPTION:Gene expression, mutation analysis[PMID:16857584]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:20854656]
16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11006082]
DESCRIPTION:Mutation analysis[PMID:21205886]
mycobacterial copper transport protein B essential for Cu resistance and maintenance of low intracellular Cu levels A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
REP-6, len: 1372 nt. REPI125, member of REP13E12 family.
Probable cycA,D-serine/D-alanine/glycine transporte
D-serine/alanine/glycine transporter protein CycA
Probable transmembrane protein, possibly involved in transport of sulfate
Putative initiation inhibitor protein, a soj-related protein probably involved in cell process
Possible scpA,segregation and condensation protein
segregation and condensation protein ScpA
Possible scpB,segregation and condensation protein
segregation and condensation protein ScpB
DESCRIPTION:Protein purification and characterization[PMID:19181797]
Cmk (CMP kinase) (cytidine monophosphate kinase) (ck). Belongs to the cytidylate kinase family,subfamily 1.
Belongs to the era/TRME family of GTP-binding proteins.
3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
proT, tRNA-Pro, anticodon ggg, length = 74
toxin, part of toxin-antitoxin (TA) operon with Rv1721c, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv1720c
AS1726, putative small regulatory RNA (See Arnvig and Young, 2009). Alternate 5'-ends at positions 1952400,1952375, 1952367, and 1952351.
DESCRIPTION:Gene expression, mutation analysis[PMID:16027371]
NADP+ dependent. Belongs to the aldehyde dehydrogenases family.
MTS1338, putative small regulatory RNA (See Arnvig et al., 2011), 5'-end mapped by RLM-RACE, alternate 5'-end at position 1960601, ~100 bp band detected by Northern blot.
Contains three domains: N-terminus respiratory nitrate reductase 1 alpha chain. Central region respiratory nitrate reductase (delta chain), C-terminus respiratory nitrate reductase (gamma chain)
nitrate/nitrite-transport integral membrane protein
EXISTENCE:Gene expression[PMID:18255326]
part of toxin-antitoxin (TA) operon with Rv1741
toxin, part of toxin-antitoxin (TA) operon with Rv1740, contains PIN domain
DESCRIPTION:Gene expression, protein purification and characterization[PMID:12927792]
DESCRIPTION:Protein purification and characterization[PMID:15967413]
Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
DESCRIPTION:Protein purification and characterization[PMID:11496007]
protein kinase F (STPK F); Experimental studies show evidence of auto-phosphorylation. Start site chosen by homology, may extend further upstream.
ABC transporter ATP-binding protein/permease
78 bp imperfect direct repeat 6, CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCCGCCAACATCACCGT
78 bp imperfect direct repeat 5, CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT
78 bp imperfect direct repeat 4, CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT
78 bp imperfect direct repeat 3, GGGTGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT
78 bp imperfect direct repeat 2, CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT
78 bp imperfect direct repeat 1, TCCCGCCTTCAGTCTGCCGGCAATAACGCTGCCGTCGCTGAACATCCCGGCCGCCACC ACACCGGCCAACATCACCGT
IS6110-3, len: 1355 nt. Insertion sequence IS6110.
28 bp inverted repeat at the left end of IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC.
28 bp inverted repeat at the right end of IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC
Probable cut1,serine esterase, cutinase family
Wag22,antigen member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins
IS6110-4, len: 1355 nt. Insertion sequence IS6110.
ISB9', len: 1230 nt. Insertion sequence ISB9, nearly identical to EM_BA:MTU78639. Note that this sequence shows several differences to EM_BA: MTU78639, and the transposase ORFs are extensively frameshifted. Our sequence has been checked and is thought to be correct; the sequence in EM_BA:MTU78639 is from a different isolate of Mycobacterium tuberculosis.
14 bp Inverted repeat at the left end of ISB9',ATCACCCCGCAAAG
14 bp Inverted repeat at the right end of ISB9,ATCACCCCGGCAAG
DESCRIPTION:Protein purification and characterization[PMID:16956367]
Probable transcriptional regulator belonging to IclR family
DESCRIPTION:Protein purification and characterization[PMID:20621636]
amylomaltase (disproportionating enzyme) (D-enzyme)
ESX-5 type VII secretion system protein EccB5
ESX-5 type VII secretion system protein EccC5
ESX-5 type VII secretion system protein EccD
serine protease (subtilisin-like protease) (subtilase-like) (mycosin-5)
ESX-5 type VII secretion system protein EccE
ESX-5 type VII secretion system protein EccA
This region is a possible MT-complex-specific genomic island (See Becq et al.,2007 PMID:17545187).
Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of ala-, gly-rich proteins. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007 PMID:17545187).
DESCRIPTION:Gene expression, mutation analysis[PMID:23407640]
vitamin B12 transport ATP-binding protein BacA
DESCRIPTION:Gene expression, protein purification and characterization[PMID:20884690]
acetolactate synthase large subunit IlvG
DESCRIPTION:Mutation analysis[PMID:11713254]
DESCRIPTION:Gene expression[PMID:10889206]
2 (PGP synthase) (phosphatidylglycerophosphate synthase) (3-phosphatidyl-1'-glycerol-3'phosphate synthase)
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
DESCRIPTION:Gene expression, mutation analysis[PMID:19019160]
GarA, conserved protein with forkhead-associated domain at C-terminus
glycine decarboxylase (glycine cleavage system P-protein),glycine dehydrogenase [decarboxylating]. The glycine cleavage system is composed of four proteins: P, T, L, and H
toxin, part of toxin-antitoxin (TA) operon with Rv1839c, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv1838c
DESCRIPTION:Protein purification and characterization[PMID:19154333]
DESCRIPTION:Protein purification and characterization[PMID:7559354]
DESCRIPTION:Protein purification and characterization[PMID:17309280]
molybdate ABC transporter substrate-binding lipoprotein ModA
molybdenum ABC transporter permease ModB
molybdenum ABC transporter ATP-binding protein ModC
DESCRIPTION:Gene expression[PMID:11282194]
DESCRIPTION:Gene expression[PMID:12654810]
fibronectin attachment protein (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) Known to be glycosylated fibronectin-binding protein (see some citations). Changes in the mannosylation pattern of this protein affect its ability to stimulate T-lymphocyte response. Major immunodominant antigen that has potential as a vaccine against tuberculosis. APA-ELISA could be used in diagnosis.
EXISTENCE:Mass spectrometry[PMID:16000731]
EXISTENCE:Protein crystalography[PMID:18453710]
DESCRIPTION:Gene expression, mutation analysis[PMID:18186793]
DESCRIPTION:Protein purification and characterization[PMID:15654876]
DESCRIPTION:Protein purification and characterization[PMID:16752890]
DESCRIPTION:Protein purification and characterization[PMID:17146044]
chorismate mutase, AroQ class; secreted, possible role in host-pathogen interactions
DESCRIPTION:Gene expression, mutation analysis[PMID:12010501]
DESCRIPTION:Protein binding analysis[PMID:3141278]
DESCRIPTION:Protein purification and characterization[PMID:9162010]
FbpB Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen); binds fibronectin facilitating attachment to host cells; also involved in maintaining cell wall integrity through the transfer of mycolyic acids
diacylglycerol acyltransferase/mycolyltransferase Ag85B
AS1890, putative small regulatory RNA (See Arnvig and Young, 2009). Alternate 5'-ends at positions 2139466,2139548, 2139594.
S-adenosyl-L-methionine-dependent methyltransferase
competence damage-inducible protein CinA
sialic acid-transport integral membrane protein NanT
DESCRIPTION:Gene expression, mutation analysis[PMID:10463167]
DESCRIPTION:Mutation analysis, protein purification and characterization[PMID:10051449]
KatG,catalase-peroxidase-peroxynitritase T. Belongs to the peroxidase family. Bacterial peroxidase/catalase subfamily. KATG transcription seems to be regulated by FURA|Rv1909c product. The catalase-peroxidase activity is associated with the amino-terminal domain but no definite function has been assigned to the carboxy-terminal domain.
69 bp imperfect direct repeat 3, TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCC CGGCTTCACCAT
69 bp imperfect direct repeat 2, TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCC TGGTTTCGCGA
69 bp imperfect direct repeat 1, TTAATCCGTTCGGTTTGAATATTCCGCTGAGCGGTGCTACCAACGCTGTCACGATCCC TGGTTTCGCGA
69 bp imperfect direct repeat 5, TCGGTCCGATTGTGGTGCCTGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG
69 bp imperfect direct repeat 4, TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG
69 bp imperfect direct repeat 3, TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG
69 bp imperfect direct repeat 2, TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG
69 bp imperfect direct repeat 1, TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG
antigen Mpt63/MPB63 (16 kDa immunoprotective extracellular protein)
DESCRIPTION:Protein purification and characterization[PMID:18585390]
part of toxin-antitoxin (TA) operon with Rv1943c
part of toxin-antitoxin (TA) operon with Rv1942
Member of Mycobacterium tuberculosis REP13E12 repeat family.
REP-7, len: 1362 nt. REP09F9, member of the REP13E12 family. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
part of toxin-antitoxin (TA) operon with Rv1953
toxin, part of toxin-antitoxin (TA) operon with Rv1952, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv1956. Upon expression in E. coli has been shown to function as an antitoxin against Rv1956 (PubMed: 19016878); It is not clear if these conflicting results are due to expression in a heterologous system; In various publications, both gene names higA and higB have been assigned to both Rv1955 and Rv1956; we have chosen to call Rv1955 higB after consulting the authors.
part of toxin-antitoxin (TA) operon with Rv1955. Upon expression in E.coli Rv1956 has been shown to function as a toxin inhibiting cell growth and colony formation that is neutralized by coexpression with Rv1955 (PubMed: 19016878); It is not clear if these conflicting results are due to expression in a heterologous system. The gene names higA and higB have been assigned to both Rv1955 and Rv1956; we have chosen to call Rv1956 higA after consulting the authors.
EXISTENCE:Gene expression[PMID:21536872]
part of toxin-antitoxin (TA) operon with Rv1960c
part of toxin-antitoxin (TA) operon with Rv1959c
toxin, part of toxin-antitoxin (TA) operon with Rv1962A, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv1962c
DESCRIPTION:Gene expression, mutation analysis[PMID:18304349]
DESCRIPTION:Gene expression[PMID:12368433]
part of mce3 operon and member of YrbE family
belongs to 24-membered Mycobacterium tuberculosis Mce protein family
APC family possibly involved in transport of amino acid
ribonucleotide reductase small subunit (R2F protein)
ribonucleoside-diphosphate reductase subunit beta NrdF1
toxin, part of toxin-antitoxin (TA) operon with Rv1982A,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv1982c
23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)
DESCRIPTION:Gene expression[PMID:1762303]
DESCRIPTION:Gene expression[PMID:18258191]
toxin, part of toxin-antitoxin (TA) operon with Rv1991A. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
MazE6, antitoxin, part of toxin-antitoxin (TA) operon with Rv1991c.
DESCRIPTION:Protein purification and characterization[PMID:12939264]
DESCRIPTION:Protein purification and characterization[PMID:12524453]
cortisone reductase ((R)-20-hydroxysteroid dehydrogenase)
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase
VapB15, antitoxin,part of toxin-antitoxin (TA) operon with Rv2010
toxin, part of toxin-antitoxin (TA) operon with Rv2009, contains PIN domain
IS1607, len: 1228 nt. Vestigial Insertion sequence element, IS1607.
Hypothetical unknown protein (pseudogene), Note that a deletion of DNA (RvD1 region) in Mycobacterium tuberculosis strain H37Rv resulted in a truncated CDS comparatively to Mycobacterium bovis or Mycobacterium tuberculosis strain CDC1551 genomes (see citations below).
DESCRIPTION:Gene expression[PMID:17726022]
DESCRIPTION:Gene expression, mutation analysis[PMID:15033981]
two component sensor histidine kinase DosT
heat shock protein HspX; alpha-crystallin homolog (14 kDa antigen) (HSP16.3)
EXISTENCE:Gene expression[PMID:11854240]
ArsR family HTH-type transcriptional repressor
Probable sugar-transport ATP-binding protein ABC transporter. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop).
sugar ABC transporter ATP-binding protein
sugar ABC transporter substrate-binding lipoprotein
DESCRIPTION:Mutation analysis[PMID:11171040]
involved in susceptibility or resistance to antituberculous drug pyrazinamide.
ASpks, putative small regulatory RNA (See Arnvig and Young, 2009). Alternate 5'-ends at positions 2299785 and 2299796. Alternate 3'-end at position 2299873. This sequence is repeated in pks12|Rv2048c at position 2305814-2305955.
DESCRIPTION:Protein purification and characterization[PMID:22570422]
DESCRIPTION:Protein purification and characterization[PMID:23548911]
DESCRIPTION:Gene expression[PMID:11931640]
Transfers mannose from GDP-Mannose to all endogenous polyprenol-phosphates in Mycobacterium tuberculosis
MazE7, antitoxin, part of toxin-antitoxin (TA) operon with Rv2063A
toxin, part of toxin-antitoxin (TA) operon with Rv2063
bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase
DESCRIPTION:Gene expression[PMID:18217931]
DESCRIPTION:Protein purification and characterization[PMID:16870770]
DESCRIPTION:Gene expression, mutation analysis[PMID:16735723]
EXISTENCE:Protein crystalography[PMID:17145760]
79 bp Mycobacterial Interspersed Repetitive Unit,Class I
PNP/PMP oxidase (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase)
IS1556, len: 1469 nt. Possible Insertion sequence-like region. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
DESCRIPTION:Protein purification and characterization[PMID:20185505]
This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187). Cofactor: requires divalent cations for activity.
transmembrane serine/threonine-protein kinase PknJ
Belongs to the SKI2 subfamily of helicases.
Sec-independent protein translocase transmembrane protein TatC
Sec-independent protein translocase membrane-bound protein TatA
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:17277063]
Belongs to the carboxylate amine/ammonia ligase family.
toxin, part of toxin-antitoxin (TA) operon with Rv2104c,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv2103c
IS6110-5, len: 1355 nt. Insertion sequence IS6110.
28bp inverted repeat at the left end of IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC
28bp inverted repeat at the right end of IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC
Member of mycobacterial PE family. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
DESCRIPTION:Gene expression[PMID:16468985]
DESCRIPTION:Gene expression, mutation analysis[PMID:18832610]
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:20705495]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:19448618]
56 bp direct repeat 1, GCCCGCCGACGATGCGGGCCGCGCAGCGGGCCGCTGAGGAGGCGGGCATCAAGCAA
56 bp direct repeat 2, GCCCGCCGACGATGCGGGCCGCGCAGCGGGCCGCTGAGGAGGCGGGCATCAAGCAA
DESCRIPTION:Gene expression, mutation analysis[PMID:15659170]
DESCRIPTION:Protein purification and characterization[PMID:14960715]
S-adenosyl-l-methionine-dependent RNA methyltransferase. The larger catalytic C-terminal domain binds the cofactor S-adenosyl-l-methionine (AdoMet) and is involved in the transfer of methyl group from AdoMet to the substrate.
tRNA (adenine(58)-N(1))-methyltransferase
DESCRIPTION:Protein purification and characterization[PMID:12511575]
DESCRIPTION:Protein purification and characterization[PMID:18560150]
MetH, 5-methyltetrahydrofolate--homocysteine methyltransferase MetH
DESCRIPTION:Protein purification and characterization[PMID:12033919]
cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:18454554]
3'(2'),5'-bisphosphate nucleotidase CysQ
leuU, tRNA-Leu, anticodon gag, length = 86
part of toxin-antitoxin (TA) operon with Rv2142A
part of toxin-antitoxin (TA) operon with Rv2142c
DESCRIPTION:Gene expression, mutation analysis, protein localization[PMID:18310019]
DESCRIPTION:Gene expression, mutation analysis[PMID:20066037]
DESCRIPTION:Gene expression, protein localization[PMID:11932443]
UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase
UDP-N-acetylmuramoylalanine--D-glutamate ligase
phospho-N-acetylmuramoyl- pentappeptidetransferase
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase
UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
Member of M. tuberculosis PE_PGRS family. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
penicillin-binding membrane protein PbpB
IS6110-6, len: 1355 nt. Insertion sequence IS6110.
28 bp Inverted repeat at the left end of IS6110; GAGTCTCCGGACTCACCGGGGCGGTTCA
ggppsase (GGPP synthetase) (geranylgeranyl diphosphate synthase)
geranylgeranyl pyrophosphate synthetase IdsA
DESCRIPTION:Gene expression, mutation analysis[PMID:17714444]
DESCRIPTION:Protein purification and characterization[PMID:19457863]
mcr5, fragment of putative small regulatory RNA (See DiChiara et al., 2010), cloned from M. bovis BCG Pasteur; ends not mapped, ~82 nt band detected by Northern blot.; Fragment of putative small regulatory RNA
DESCRIPTION:Protein purification and characterization[PMID:18175374]
IS1558-1, len: 804 nt. Insertion sequence IS1558,nearly identical to complement of region 24105 24908 in EM_BA:MTCY428 Z81451 Mycobacterium tuberculosis cosmid Y428.
DESCRIPTION:Protein purification and characterization[PMID:16288916]
DAHP synthetase, phenylalanine-repressible
phospho-2-dehydro-3-deoxyheptonate aldolase AroG
DESCRIPTION:Protein purification and characterization[PMID:24311791]
DESCRIPTION:Gene expression[PMID:16945913]
alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase
1-acylglycerol-3-phosphate O-acyltransferase
long-chain-fatty-acid--CoA ligase FadD15
alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase
DESCRIPTION:Gene expression, protein crystalization[PMID:16337227]
Ubiquinol-cytochrome C reductase cytochrome C subunit
ubiquinol-cytochrome C reductase cytochrome subunit C
ubiquinol-cytochrome C reductase rieske iron-sulfur subunit
58 bp Mycobacterial Interspersed Repetitive Unit,Class II I. Overlaps Rv2195 suggesting alternative GTG start at 2458 468 may be used
ubiquinol-cytochrome C reductase cytochrome subunit B
DESCRIPTION:Protein purification and characterization[PMID:14594827]
nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase
adenosylcobinamide-GDP ribazoletransferase
DESCRIPTION:Protein purification and characterization[PMID:19923721]
branched-chain amino acid aminotransferase
DESCRIPTION:Protein purification and characterization[PMID:16925585]
ATP pyrophosphate-lyase, adenylate cyclase
DESCRIPTION:Gene expression, mutation analysis[PMID:16045627]
pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase
DESCRIPTION:Protein purification and characterization[PMID:16735476]
DESCRIPTION:Gene expression, mutation analysis[PMID:9278431]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:12146952]
DESCRIPTION:Mutation analysis[PMID:12819079]
glutamine-synthetase adenylyltransferase
[glutamate--ammonia-ligase] adenylyltransferase
18 bp inverted repeat between 3' end of MTCY427.04c and 5' end of MTCY427.03c
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:17428787]
DESCRIPTION:Protein purification and characterization[PMID:12515554]
3-methyl-2-oxobutanoate hydroxymethyltransferase
Multifunctional protein with RNase H, alpha-ribazole phosphatase, and acid phosphatase activities.
multifunctional RNASE H/alpha-ribazole phosphatase/acid phosphatase
toxin, part of toxin-antitoxin (TA) operon with Rv2231B
antitoxin, part of toxin-antitoxin (TA) operon with Rv2231A
protein tyrosine kinase transcriptional regulator PtkA
DESCRIPTION:Gene expression, protein purification and characterization[PMID:12066895]
phosphotyrosine protein phosphatase (PTPase) (LMW phosphatase), low molecular weight protein-tyrosine-phosphatase
cobalamin biosynthesis transmembrane protein CobD
valV, tRNA-Val, anticodon tac, length = 72
pyruvate decarboxylase (pyruvate dehydrogenase) (pyruvic dehydrogenase)
DESCRIPTION:Gene expression, mutation analysis[PMID:11373295]
mcr16, putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, ~100 nt band detected by Northern blot.
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11420175]
meromycolate extension acyl carrier protein
DESCRIPTION:Protein purification and characterization[PMID:11600501]
beta-ketoacyl-ACP synthase (KAS I); belongs to the fas-II system, which utilizes primarily palmitoyl-ACP rather than short-chain acyl-ACP primers.
58 bp inverted repeat near 3'end of MTCY427.28
53 bp inverted repeat between 3' ends of MTCY427.29 and MT CY427.31c
DESCRIPTION:Gene expression, protein purification and characterization[PMID:16689792]
50 bp Mycobacterial Interspersed Repetitive Unit,Class II
part of toxin-antitoxin (TA) operon with Rv2274c
DESCRIPTION:Protein purification and characterization[PMID:20852636]
DESCRIPTION:Protein purification and characterization[PMID:19416919]
EXISTENCE:Protein crystalography[PMID:11914502]
mycocyclosin synthase; catalyzes the formation of mycocyclosin from cyclotyrosine
3 bp direct repeat, ccg, flanking IS6110
IS6110-7, len: 1355 nt. Insertion sequence IS6110.
similar to insertion sequence element IS986/IS6110 transposase; Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation, the sequence UUUUAAAG maybe responsible for such a frameshifting event (see McAdam et al., 1990)
28 bp inverted repeat at the right end of IS6110,GAGTCTCCGGACTCACCGGGGCGGTTCA
LysR family HTH-type transcriptional regulator
Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase)
heat shock protein (HSP90 family protein) (high temperature protein G)
This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
sugar ABC transporter substrate-binding lipoprotein UspC
cationic amino acid transporter permease RocE
[NAD] dependent; Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarboxylating)) (pyruvic-malic carboxylase) (NAD-me)
DESCRIPTION:Gene expression, mutation analysis[PMID:17242035]
DESCRIPTION:Protein purification and characterization[PMID:17567578]
cysteine synthase CysK (O-acetylserine (thiol)-lyase A) (CSASE A)
asnT, tRNA-Asn, anticodon gtt, length = 73
Dgt (dGTPase) (dGTP triphosphohydrolase)
deoxyguanosine triphosphate triphosphohydrolase
DESCRIPTION:Gene expression[PMID:8757862]
IS6110-8, len: 1355 nt. Insertion sequence IS6110 element that appears to have inserted in 5'-end of MTCY98.031c but is not flanked by expected 3 bp direct repeats of target sequence.
28 bp Inverted repeat, TGAACCGCCCCGGCATGTCCGGAGACTC,at the left end of IS6110
28 bp Inverted repeat, TGAACCGCCCCGGTGAGTCCGGAGACTC,at the right end of IS6110
glycyl-tRNA synthetase. Belongs to class-II aminoacyl-tRNA synthetase family.
DESCRIPTION:Gene expression, mutation analysis[PMID:17098899]
DESCRIPTION:Gene expression[PMID:10816587]
DESCRIPTION:Protein purification and characterization[PMID:15516568]
Long (C50) chain (Z-decaprenyl diphosphate synthase)
phosphate starvation-inducible protein PhoH
heat-inducible transcription repressor HrcA
DESCRIPTION:Protein purification and characterization[PMID:16461464]
L-lysine 6-monooxygenase (lysine N6-hydroxylase)
DESCRIPTION:Protein purification and characterization[PMID:16923875]
coproporphyrinogenase (coprogen oxidase)
oxygen-independent coproporphyrinogen III oxidase
DESCRIPTION:Gene expression[PMID:15207486]
DESCRIPTION:Protein purification and characterization[PMID:17576074]
DESCRIPTION:Protein purification and characterization[PMID:15917234]
PAPS reductase, thioredoxin DEP, (padops reductase) (3'-phosphoadenylylsulfate reductase) (PAPS sulfotransferase)
phosphoadenosine phosphosulfate reductase
78 bp Mycobacterial Interspersed Repetitive Unit,Class I
gamma-glutamyltransferase (glutamyl transpeptidase)
gamma-glutamyltranspeptidase precursor GgtB
mcr7, putative small regulatory RNA (See DiChiara et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur, 3'-end not mapped.
DESCRIPTION: similar to sequence:INSD:AAK46761.1
restricted to M. tuberculosis complex. Note completely overlapped by sRNA mcr7.
acid and phagosome regulated protein AprA
DESCRIPTION: similar to AA sequence:INSD:AAK46762.1
acid and phagosome regulated protein AprB
member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, restricted to M. tuberculosis complex
acid and phagosome regulated protein AprC
DESCRIPTION:Gene expression, mutation analysis[PMID:11929522]
sulfate ABC transporter ATP-binding protein CysA
sulfate ABC transporter substrate-binding lipoprotein SubI
DESCRIPTION:Gene expression, mutation analysis[PMID:17259625]
DESCRIPTION:Gene expression[PMID:10629183]
77 bp Mycobacterial Interspersed Repetitive Unit,Class I
DESCRIPTION:Gene expression, protein purification and characterization[PMID:22355692]
gpgP, glucosyl-3-phosphoglycerate phosphatase. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. Belongs to the phosphoglycerate mutase family. Enzyme activity inhibited by Co2+ and Cu2+.
deamido-NAD(+) pyrophosphorylase (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase)
nicotinate-nucleotide adenylyltransferase
13 bp inverted repeat, GCAGTCG(C)AAAAG, at the left end of IS1558
IS1558-2, len: 999 nt. Insertion sequence IS1558.
13 bp inverted repeat, GCAGTCG(T)AAAAG, at the right end of IS1558
GPR (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase)
Rv2427A, Pseudogene oxyR', inactivated by multiple mutations; identical to sequence in u16243 (see Deretic et al., 1995).
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:10766746]
DESCRIPTION:Gene expression, mutation analysis[PMID:15886207]
DESCRIPTION:Protein purification and characterization[PMID:11171096]
alkyl hydroperoxide reductase subunit AhpC
DESCRIPTION:Mutation analysis, protein purification and characterization[PMID:12761216]
Belongs to the PFKB family of carbohydrate kinases.
C4-dicarboxylate-transport transmembrane protein DctA
NDK (NDP kinase) (nucleoside-2-P kinase)
folylpoly-gamma-glutamate synthetase (FPGS)
valyl-tRNA synthase protein ValS (valyl-tRNA synthetase)
molybdopterin-guanine dinucleotide biosynthesis protein MobA
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:19936047]
2-oxoglutarate oxidoreductase subunit KorB
2-oxoglutarate oxidoreductase subunit KorA
ATP-dependent CLP protease ATP-binding subunit ClpX
S-methylmethionine:homocysteine methyltransferase (cysteine methyltransferase)
ATP-dependent CLP protease proteolytic subunit 2
ATP-dependent CLP protease proteolytic subunit 1
proU, tRNA-Pro; anticodon tgg, length = 74
glyV, tRNA-Gly; anticodon tcc, length = 71
DESCRIPTION:Gene expression, protein purification and characterization[PMID:14687575]
DESCRIPTION:Protein purification and characterization[PMID:15590681]
Lysyl aminopeptidase (LYS-AP) (alanine aminopeptidase)
DESCRIPTION:Protein purification and characterization[PMID:11796724]
maltase (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidase) (acid maltase)
Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
IS6110-9, len: 1357 nt. Insertion sequence IS6110.
29 bp Inverted repeat at the left end of IS6110,GTGAACCGCCCCGGTGAGTCCGGAGACTC
similar to insertion sequence element IS986/IS6110 transposase; Probable transposase for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation, the sequence UUUUAAAG maybe responsible for such a frameshifting event (see McAdam et al., 1990).
29 bp Inverted repeat at the right end of IS6110,GTGAACCGCCCCGGCATGTCCGGAGACTC
bifunctional L-3-phosphoserine phosphatase/1-acyl-sn-glycerol-3-phosphate acyltransferase
triacylglycerol synthase; A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).
argW, tRNA-Arg; anticodon tct, length = 74
258 bp direct repeat 2. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
part of toxin-antitoxin (TA) operon with Rv2494. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv2493,contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
branched-chain keto acid dehydrogenase E2 component
3-methyl-2-oxobutanoate dehydrogenase subunit beta
3-methyl-2-oxobutanoate dehydrogenase subunit alpha
citrase (citratase) (citritase) (citridesmolase) (citrase aldolase)
AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase)
succinyl-CoA:3-ketoacid-CoA transferase subunit B
ScoA (3-oxo acid:CoA transferase) (OXCT A) (succinyl-CoA:3-oxoacid-CoAtransferase)
succinyl-CoA:3-ketoacid-CoA transferase subunit A
hisT, tRNA-His, anticodon gtg, length = 73
IS1081-3, len: 1450 nt. Insertion sequence IS1081.
lysU, tRNA-Lys, anticodon ctt, length = 73
PE26, Member of the M. tuberculosis PE family
holo-ACP synthase (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-ACPpantetheinephosphotransferase)
part of toxin-antitoxin (TA) operon with Rv2527
toxin, part of toxin-antitoxin (TA) operon with Rv2526,contains PIN domain
toxin, part of toxin-antitoxin (TA) operon with Rv2530A,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv2530c
EXISTENCE:Protein crystalography[PMID:10881194]
AROQ (3-dehydroquinase) (type II dhqase)
DESCRIPTION:Gene expression, protein purification and characterization[PMID:17586643]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:11483005]
5-enolpyruvylshikimate-3-phosphate phospholyase
part of toxin-antitoxin (TA) operon with Rv2546
toxin, part of toxin-antitoxin (TA) operon with Rv2545,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv2548
toxin, part of toxin-antitoxin (TA) operon with Rv2547
toxin, part of toxin-antitoxin (TA) operon with Rv2550c,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv2549c
Probable alaS, alanyl-tRNA synthetase, (alanine translase) (ALARS)
mpr11, fragment of putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, 82-100 nt band detected by Northern blot in M. bovis BCG Pasteur.; Fragment of putative small regulatory RNA
mpr12, fragment of putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, ~118 nt band detected by Northern blot in M. bovis BCG Pasteur.; Fragment of putative small regulatory RNA
Probable aspS, aspartyl-tRNA synthetase (ASPRS) (aspartic acid translase)
Probable hisS, histidyl-tRNA synthetase (HISRS) (histidine--translase)
hydroxyacylglutathione hydrolase (GLX II) Cofactor: binds two zinc ions.
cyclophilin (PPIase) (rotamase) (peptidylprolyl isomerase)
DESCRIPTION:Protein purification and characterization[PMID:10375643]
ATP:GTP 3'-pyrophosphotransferase (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
bifunctional (p)ppGpp synthase/hydrolase RelA
Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)
gamma-amino-N-butyrate transaminase (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at)
Holliday junction ATP-dependent DNA helicase RuvB
Holliday junction ATP-dependent DNA helicase RuvA
holliday junction nuclease (holliday junction resolvase)
crossover junction endodeoxyribonuclease RuvC
part of toxin-antitoxin (TA) operon with Rv2596
toxin, part of toxin-antitoxin (TA) operon with Rv2595,contains PIN domain
putrescine aminopropyltransferase (aminopropyltransferase) (SPDSY)
part of toxin-antitoxin (TA) operon with Rv2602
toxin, part of toxin-antitoxin (TA) operon with Rv2601A, contains PIN domain
EXISTENCE:Protein crystalography[PMID:16374842]
DESCRIPTION:Gene expression, mutation analysis[PMID:12068013]
alpha-(1-2)-phosphatidylinositol mannosyltransferase
DESCRIPTION:Gene expression, mutation analysis[PMID:12851411]
phosphatidylinositol mannoside acyltransferase
DESCRIPTION:Gene expression, mutation analysis[PMID:10889206]
PI synthase/CDP-diacylglyceride--inositol phosphatidyltransferase (CDP-diacylglycerol--inositol-3-phosphatidyltransferase)
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
DESCRIPTION:Protein purification and characterization[PMID:19778616]
threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS)
EXISTENCE:Gene expression[PMID:11425467]
EXISTENCE:Mass spectrometry[PMID:10510226]
arsenic-transport integral membrane protein ArsC
valT, tRNA-Val, anticodon cac, length = 72
glyT, tRNA-Gly, anticodon gcc, length = 73
cysU, tRNA-Cys, anticodon gca, length = 71
valU, tRNA-Val, anticodon gac, length = 72
3 bp direct repeat: TCG at 5'-end of IS6110
IS6110-10, len: 1355 nt. Insertion sequence IS6110.
28 bp inverted repeat: TGAACCGCCCCGGCATGTCCGGAGACTC at the left end of IS6110
3 bp direct repeat: TCG at 3'-end of IS6110
IS1081'-4, len: 909 nt. Defective Insertion sequence IS1081 element; truncated at 3'-end.
15 bp Inverted repeat at the left end of IS1081:TCGCGTGATCCTTCG, right end copy is missing
ATP-dependent protease ATP-binding subunit ClpC
ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein
bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase
DESCRIPTION:Gene expression, mutation analysis[PMID:18627460]
DESCRIPTION:Gene expression, mutation analysis[PMID:19040639]
protein-methionine-R-oxide reductase (peptide met(O) reductase)
peptide methionine sulfoxide reductase MsrB
protoporphyrinogen-IX oxidase (protoporphyrinogenase) (PPO)
uroporphyrinogen III decarboxylase (URO-D) (UPD)
Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
arsenic-transport integral membrane protein ArsA
arsenic-transport integral membrane protein ArsB
DESCRIPTION:Gene expression[PMID:15273144]
TRK system potassium uptake protein CeoB
TRK system potassium uptake protein CeoC
51 bp Mycobacterial Interspersed Repetitive Unit,Class I
EXISTENCE:Protein crystalography[PMID:15276840]
Dut (dUTPase) (dUTP pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dUTP diphosphatase) (deoxyuridine-triphosphatase)
deoxyuridine 5'-triphosphate nucleotidohydrolase
DESCRIPTION:Protein purification and characterization[PMID:11914086]
DESCRIPTION:Protein purification and characterization[PMID:8617763]
polyphosphate-glucose phosphotransferase
DESCRIPTION:Gene expression[PMID.9882660]
DESCRIPTION:Gene expression[PMID:7644534]
DESCRIPTION:Gene expression, mutation analysis[PMID:19592585]
DESCRIPTION:Gene expression, mutation analysis[PMID:12065475]
DESCRIPTION:Gene expression[PMID:11722747]
iron-dependent repressor and activator IdeR
STH (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleotide transhydrogenase)
DESCRIPTION:Protein purification and characterization[PMID:18269631]
IPP transferase (isopentenyl-diphosphate:tRNA isopentenyltransferase) (iptase) (IPPT)
tRNA delta(2)-isopentenylpyrophosphate transferase
(dimethylallyl)adenosine tRNA methylthiotransferase
DESCRIPTION:Protein purification and characterization[PMID:12218174]
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:8639660]
contains: endonuclease PI-MTUI (MTU RecA intein)
DESCRIPTION:Protein purification and characterization[PMID:16051262]
Member of the M. tuberculosis PE family. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
ClgR,transcriptional regulatory protein, controls protease systems and chaperones.
PGP synthase PgsA (phosphatidylglycerophosphate synthase)
DESCRIPTION:Protein purification and characterization[PMID:15838060]
DESCRIPTION:Protein purification and characterization[PMID:18062777]
4-hydroxy-tetrahydrodipicolinate synthase
type I restriction/modification system DNA methylase HsdM
toxin, part of toxin-antitoxin (TA) operon with Rv2758c,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv2757c
toxin, part of toxin-antitoxin (TA) operon with Rv2760c,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv2759c
type I restriction/modification system specificity determinant HsdS
51 bp Mycobacterial Interspersed Repetitive Unit,Class III
DESCRIPTION:Protein purification and characterization[PMID:16648861]
DESCRIPTION:Gene expression[PMID:9098082]
4-hydroxy-tetrahydrodipicolinate reductase
Lrp/AsnC family transcriptional regulator
EXISTENCE:Protein crystalography[PMID:18491387]
bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase
bifunctional riboflavin kinase /FMN adenylyltransferase
IS1602, len: 2032 nt. Insertion sequence IS1602.
EXISTENCE:Protein crystalography[PMID:15028724]
tRNA pseudouridine 55 synthase (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase)
CoA:APO-[ACP]pantetheinephosphotransferase (CoA:APO-ACPpantetheinephosphotransferase)
toxin, part of toxin-antitoxin (TA) operon with Rv2801A
part of toxin-antitoxin (TA) operon with Rv2801c. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187)
IS1555', len: 399 nt. Probable defective Insertion sequence element, IS1555. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
IS1604, len: 1409 nt. Insertion sequence IS1604. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
4392 bp direct repeat region. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
36 bp direct repeat, 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
36 bp direct repeat, 35 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
20 bp partial direct repeat, CCCCGAGAGGGGACGGAAAC,of sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
IS6110-11, len: 1375 nt. Insertion sequence IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
similar to insertion sequence element IS6110 transposase(fragment); Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation, the sequence UUUUAAAG maybe responsible for such a frameshifting event (see McAdam et al., 1990). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
16 bp partial direct repeat, GTCGTCAGACCCAAAA, of sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
36 bp direct repeat, 32 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
CRISPR type III-associated RAMP protein Csm5
CRISPR type III-associated RAMP protein Csm4
CRISPR type III-associated RAMP protein Csm3
toxin, part of toxin-antitoxin (TA) operon with Rv2830c, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv2829c
sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC
sn-glycerol-3-phosphate ABC transporter substrate-binding lipoprotein UgpB
sn-glycerol-3-phosphate ABC transporter permease UgpE
sn-glycerol-3-phosphate ABC transporter permease UgpA
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:22114320]
3'(2'),5'-bisphosphate nucleotidase, (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (nanoRNase); degrades RNAs of less than 2 bases and dephosphorylates 3?-phosphoadenosine 5?-phosphate
bifunctional oligoribonuclease/PAP phosphatase NrnA
DESCRIPTION:Mutation analysis, protein purification and characterization[PMID:11743725]
transcription termination/antitermination protein NusA
prolyl-tRNA synthetase (PRORS) (global RNA synthesis factor) (proline translase)
Possible cysG urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM)/precorrin-2 oxidase/ferrochelatase
multifunctional uroporphyrin-III C-methyltransferase/precorrin-2 oxidase/ferrochelatase
54 bp direct repeat 4,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTAGGCTTGGC
54 bp direct repeat 3,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT
54 bp direct repeat 2,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT
54 bp direct repeat 1,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT
corrinoid adenosyltransferase (corrinoid adotransferase activity)
62 bp Mycobacterial Interspersed Repetitive Unit,Class III
DESCRIPTION:Protein purification and characterization[PMID:10512639]
DESCRIPTION:Protein purification and characterization[PMID:11318633]
nickel-transport integral membrane protein NicT
51 bp direct repeat 1,GTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC
51 bp direct repeat 2,GTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC
(41 bp) part of 51 bp direct repeat 3,GGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC
DESCRIPTION:Protein purification and characterization[PMID:19688379]
part of toxin-antitoxin (TA) operon with Rv2863
toxin, part of toxin-antitoxin (TA) operon with Rv2862A,contains PIN domain
DESCRIPTION:Gene expression[PMID:19114484]
RelF, antitoxin,part of toxin-antitoxin (TA) operon with Rv2866
RelG, toxin, part of toxin-antitoxin (TA) operon with Rv2865
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
DESCRIPTION:Gene expression, mutation analysis[PMID:19496931]
Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase)
1-deoxy-D-xylulose 5-phosphate reductoisomerase
(43 bp) part of 51 bp direct repeat,GTGTCGACCCGCTGCGCCCGGCTTCGCCGTGCTTGCGATCGCC. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
part of toxin-antitoxin (TA) operon with Rv2872. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
toxin, part of toxin-antitoxin (TA) operon with Rv2871,contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
integral membrane C-type cytochrome biogenesis protein DipZ
major secreted immunogenic protein Mpt70
DESCRIPTION:Protein purification and characterization[PMID:10089161]
CDP-diglyceride synthetase (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase)
UK (uridine monophosphate kinase) (UMP kinase)
IS1539, len: 2267 nt. Insertion sequence IS1539.
formate dehydrogenase accessory protein FdhD
formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide (formate dehydrogenase-H alpha subunit) (FDH-H)
formate dehydrogenase subunit alpha FdhF
DESCRIPTION:Gene expression[PMID:22427625]
M1G-methyltransferase (tRNA [GM37] methyltransferase)
D-alanyl-D-alanine carboxypeptidase (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase)
TetR family HTH-type transcriptional regulator
DESCRIPTION:Gene expression, mutation analysis[PMID:19341393]
DESCRIPTION:Protein purification and characterization[PMID:15177288]
protein kinase I (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase)
DESCRIPTION:Gene expression[PMID:22534010]
signal recognition particle (SRP) protein (ala-, gly-,leu-rich protein)
DESCRIPTION:Gene expression, mutation analysis[PMID:17303474]
PII uridylyl-transferase (uridylyl removing enzyme) (UTASE)
bifunctional uridylyltransferase/uridylyl-removing enzyme
ammonium transporter integral membrane protein
cell division protein; SRP receptor (signal recognition particle receptor)
signal recognition particle receptor FtsY
DESCRIPTION:Protein purification and characterization[PMID:19496823]
EXISTENCE:Protein crystalography[PMID:16155207]
phthiocerol synthesis polyketide synthase type I PpsA
phthiocerol synthesis polyketide synthase type I PpsB
phthiocerol synthesis polyketide synthase type I PpsC
phthiocerol synthesis polyketide synthase type I PpsD
phthiocerol synthesis polyketide synthase type I PpsE
DESCRIPTION:Gene expression, mutation analysis[PMID:12057006]
daunorubicin ABC transporter ATP-binding protein DrrA
daunorubicin ABC transporter permease DrrB
daunorubicin ABC transporter permease DrrC
DESCRIPTION:Gene expression, mutation analysis[PMID:15070765]
DESCRIPTION:Protein purification and characterization[PMID:15123643]
phthiocerol/phthiodiolone dimycocerosyl transferase
multifunctional mycocerosic acid synthase
long-chain-fatty-acid--AMP ligase FadD28
IS1533, len: 2042 nt. Minimum region corresponding to Insertion sequence IS1533.
insertion sequence element IS1533 transposase
DESCRIPTION:Protein purification and characterization[PMID:20553505]
DESCRIPTION:Mutation analysis, protein purification and characterization[PMID:16210318]
DESCRIPTION:Gene expression, mutation analysis[PMID:20553505]
long-chain-fatty-acid--AMP ligase FadD29
DESCRIPTION:Gene expression, mutation analysis[PMID:17371506]
phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase
DESCRIPTION:Gene expression, mutation analysis[PMID:15292265]
phthiotriol/phenolphthiotriol dimycocerosates methyltransferase
DESCRIPTION:Gene expression, mutation analysis[PMID:17468241]
DESCRIPTION:Gene expression, mutation analysis[PMID:15292272]
PGL/p-HBAD biosynthesis glycosyltransferase
PGL/p-HBAD biosynthesis rhamnosyltransferase
pantetheine-phosphate adenylyltransferase (PPAT) (dephospho-CoA pyrophosphorylase)
55 bp Mycobacterial Interspersed Repetitive Unit,Class III
98 bp Mycobacterial Interspersed Repetitive Unit,Class III
IS1538, len: 2025 nt. Similar to other Insertion sequence elements in M. tuberculosis e.g. IS1535, IS1536,IS1537, & IS1539 (EM_NEW:MTCY274 Z74024 Mycobacterium tuberculosis cosmid Y274)
6 bp inverted repeat at the left end of IS1538,TGAGTG
6 bp inverted repeat at the right end of IS1538,TGAGTG.
D-alanylalanine synthetase (D-ala-D-ala ligase)
[NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
DESCRIPTION:Gene expression, mutation analysis[PMID:17630969]
PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase)
homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein)
isopropylmalate isomerase (alpha-IPM isomerase) (IPMI)
3-isopropylmalate dehydratase small subunit
3-isopropylmalate dehydratase large subunit
gluU, tRNA-Glu; anticodon ctc, length = 73
glnU, tRNA-Gln; anticodon ctg, length = 72
Glutamyl-tRNA synthetase GltS (glutamyl-tRNA synthase) (GLURS)
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
DESCRIPTION:Gene expression, mutation analysis[PMID:9111927]
beta-IPM dehydrogenase (IMDH) (3-IPM-DH)
acetohydroxy-acid isomeroreductase (alpha-keto-beta-hydroxylacil reductoisomerase)
EXISTENCE:Gene expression[PMID:20884690]
DESCRIPTION:Gene expression[PMID:20884690]
acetolactate synthase large subunit IlvB
aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
glutamyl-tRNA(GLN) amidotransferase subunit A
glutamyl-tRNA(GLN) amidotransferase subunit C
DESCRIPTION:Protein purification and characterization[PMID:14985346]
Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of ala-, gly-rich proteins. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
PPE47, Member of Mycobacterium tuberculosis PPE family. Should be continuation of upstream ORF MTV012.36c but is frameshifted due to missing base at 36448 in v012. Sequence has been checked but no error apparent.
PPE48, Member of M. tuberculosis PPE family with frameshift due to missing bp in codon 82. The ORF continues in downstream MTV012.35c. The sequence has been checked and no errors were detected.
IS1081-5, len: 1324 nt. Insertion sequence IS1081.
15 bp Inverted repeat at left end of IS1081:TCGCGTGATCCTTCG
15 bp Inverted repeat at the right end of IS1081:TCGCGTGATCCTTCG
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU
DESCRIPTION:Protein purification and characterization[PMID:17609286]
NIFS protein homolog (nitrogenase metalloclusters biosynthesis protein NIFS)
alpha-ETF (electron transfer flavoprotein large subunit) (ETFLS)
electron transfer flavoprotein subunit alpha
beta-ETF (electron transfer flavoprotein small subunit) (ETFSS)
electron transfer flavoprotein subunit beta
DESCRIPTION:Gene expression, mutation analysis[PMID:17640872]
DESCRIPTION:Gene expression, mutation analysis[PMID:20305657]
Alpha-1,4-glucosyltransferase (UDP-glucose--glycogen glucosyltransferase)
FeIII-dicitrate-binding periplasmic lipoprotein
DESCRIPTION:Gene expression, mutation analysis[PMID:9335290]
ribonucleoside-diphosphate reductase subunit beta NrdF2
DESCRIPTION:Protein purification and characterization[PMID:7961427]
ribonucleotide reductase small subunit (R1F protein)
ribonucleoside-diphosphate reductase subunit alpha
glutaredoxin electron transport protein NrdH
DNA-damage-inducible protein DinP; DNA polymerase V (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))
short chain alcohol dehydrogenase/reductase
ATP-dependent; polydeoxyribonucleotide synthase [ATP] (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase)
DESCRIPTION:Gene expression[PMID:9811672]
multidrugs-transport integral membrane protein
alaU, tRNA-Ala, anticodon ggc, length = 73
DESCRIPTION:Gene expression, mutation analysis[PMID:20522497]
DESCRIPTION:Protein purification and characterization[PMID:19251699]
DESCRIPTION:Gene expression, mutation analysis[PMID:14568148]
DESCRIPTION:Gene expression[PMID:10188241]
DESCRIPTION:Gene expression, mutation analysis[PMID:20027301]
long chain-fatty-acid--CoA ligase FadD13
PE-PGRS family protein Y (esterase/lipase) (triglyceride lipase) (tributyrase) This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
ssr, match to EM_BA:MT10SARNA X60301 M.tuberculosis gene for 10Sa RNA. Ends changed since first submission (-239 nt).
septation component-transport ATP-binding protein ABC transporter
DESCRIPTION:Protein purification and characterization[PMID:12071965]
DESCRIPTION:Protein purification and characterization[PMID:12614197]
alkyl-DHAP synthase (alkylglycerone-phosphate synthase)
moaA1,molybdenum cofactor biosynthesis protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
PHS (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
molybdenum cofactor biosynthesis protein MoaC; This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
molybdopterin converting factor small subunit (molybdopterin [MPT] converting factor, subunit 1) This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
molybdenum cofactor biosynthesis protein MoaD
IS1081-6, len: 1324 nt. Insertion sequence IS1081. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
15 bp inverted repeat at left end of IS1081: TCGCGTGATCCTTCG. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
15 bp inverted repeat at right end of IS1081: TCGCGTGATCCTTCG. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
MPT-synthase sulfurylase (molybdopterin synthase) This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
molybdenum cofactor biosynthesis protein MoeB
rhodanese-like protein (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
molybdopterin converting factor large subunit (molybdopterin [MPT] converting factor, subunit 2) This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
molybdopterin synthase catalytic subunit 1
DESCRIPTION:Gene expression[PMID:20378651]
Member of the Mycobacterium tuberculosis PPE family. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon
DESCRIPTION:Gene expression, mutation analysis[PMID:16946266]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:15073296]
two component sensor histidine kinase DevS
two component transcriptional regulator DevR
formate acetyltransferase activating enzyme ([pyruvate formate-lyase] activating enzyme)
pyruvate formate lyase activating protein PflA
NADPH:quinone reductase (zeta-crystallin)
NuoG (NADH dehydrogenase I subunit G) Contains respiratory-chain NADH dehydrogenase 75 kDa subunit signature 2 (PS00642). Belongs to the complex I 75 KDA subunit family. Cofactor: may bind two 4FE-4S cluster and one 2FE-2S cluster.
NuoH (NADH dehydrogenase I subunit H) Contains respiratory-chain NADH dehydrogenase subunit 1 signature 2 (PS00668). Belongs to the complex I subunit 1 family.
NuoI (NADH dehydrogenase I subunit I) Contains two 4Fe-4S ferredoxins, iron-sulfur binding region signatures (PS00198). Belongs to the complex I 23 KDA subunit family. The iron-sulfur centers are similar to those of 'bacterial-type' 4FE-4S ferredoxins. Cofactor: binds two 4FE-4S clusters.
NuoN (NADH dehydrogenase I subunit N) Belongs to the complex I subunit 2 family.
methanol dehydrogenase transcriptional regulator MoxR
EXISTENCE:Protein crystalography[PMID:21543877]
TetR/Acr family transcriptional regulator
aminohydrolase. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
epoxide hydratase (arene-oxide hydratase) This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
non-haem peroxidase, this region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
3 bp direct repeat, cga, at 5'-end of IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
IS6110-12, len: 1355 nt. Insertion sequence IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
28 bp inverted repeat at left end of IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
similar to insertion sequence element IS986/IS6110 transposase; Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation, the sequence UUUUAAAG maybe responsible for such a frameshifting event (see McAdam et al., 1990). Start changed since first submission (+ 16 aa). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).
28 bp inverted repeat at right end of IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
3 bp direct repeat, cga, at 3'-end of IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
3 bp direct repeat, att, at 5'-end of IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
IS6110-13, len: 1355 nt. Insertion sequence IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
IS1603, len: 1032 nt. Insertion sequence IS1603. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
metU, tRNA-fMet, anticodon cat, length = 74. Described in EM_BA: MTMETA Y08623 M.tuberculosis as metA gene. Name changed to metU as metA encodes homoserine transsuccinylase. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
DESCRIPTION:Gene expression[PMID:22069311]
Probable UvrD2,ATP dependent DNA helicase II
NAD+ diphosphatase (NAD+ pyrophosphatase) (NADP pyrophosphatase)
molybdenum cofactor biosynthesis protein MoeB; MPT-synthase sulfurylase (molybdopterin synthase sulphurylase)
adenylyltransferase/sulfurtransferase MoeZ
Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
isochorismate hydroxymutase (enterochelin biosynthesis)
acetyltransferase (2.3.1.-), contains GNAT domain (GCN5-like N-acetyltransferase. See Vetting et al. 2005), probably pseudogene as appears frameshifted due to 1bp insertion at position 3593438. Frameshift present in all sequenced tubercle bacilli. Start changed since first submission, extended by 50aa.
DESCRIPTION:Gene expression[PMID:20929442]
DESCRIPTION:Gene expression[PMID:22464736]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:16026786]
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
DESCRIPTION:Gene expression, protein purification and characterization[PMID:14617153]
DESCRIPTION:Gene expression, mutation analysis[PMID:11567012]
DESCRIPTION:Gene expression, mutation analysis[PMID:12123450]
iron-regulated short-chain dehydrogenase/reductase
DESCRIPTION:Gene expression, mutation analysis[PMID:2123856]
DESCRIPTION:Gene expression[PMID:11483005]
5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase) (EPSPS)
3-phosphoshikimate 1-carboxyvinyltransferase
DESCRIPTION:Gene expression, mutation analysis[PMID:14559907]
DESCRIPTION:Gene expression, mutation analysis[PMID:17087501]
stearoyl-CoA 9-desaturase electron transfer protein
DESCRIPTION:Gene expression, mutation analysis[PMID:22610443]
two component sensory histidine kinase MtrB
DESCRIPTION:Gene expression, protein purification and characterization[PMID:8655513]
DESCRIPTION:Gene expression[PMID:16629667]
two component DNA-binding response regulator MtrA
DESCRIPTION:Protein purification and characterization[PMID:11369858]
Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)
DESCRIPTION:Protein purification and characterization[PMID:18815415]
S-adenosyl-L-homocysteine hydrolase (adohcyase)
alkane 1-hydroxylase (lauric acid omega-hydroxylase) (omega-hydroxylase) (fatty acid omega-hydroxylase) (alkane hydroxylase-rubredoxin)
transmembrane alkane 1-monooxygenase AlkB
cationic amino acid transport integral membrane protein
phosphomannose isomerase (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (phosphohexomutase)
DESCRIPTION:Protein purification and characterization[PMID:22686939]
EXISTENCE:Protein crystalography[PMID:22102046]
modification methylase (methyltransferase)
D-alpha-D-heptose-1-phosphate guanylyltransferase
D-alpha-D-mannose-1-phosphate guanylyltransferase ManB
DESCRIPTION:Gene expression, mutation analysis[PMID:15294902]
dTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol,a-3-L-rhamnosyl transferase WbbL1 (alpha-L-rhamnose-(1->3)-alpha-D-GlcNAc(1->P)-P- decaprenyl)
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD; dTDP-rhamnose modification protein (dTDP-rhamnose biosynthesis protein) (dTDP-rhamnose synthase)
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:23482562]
carbonate dehydratase (carbonic dehydratase)
5-(carboxyamino)imidazole ribonucleotide mutase
5-(carboxyamino)imidazole ribonucleotide synthase
bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase
pccase (propanoyl-CoA:carbon dioxide ligase)
bifunctional protein acetyl-/propionyl-CoAcarboxylase subunit epsilon AccE
rhodanese (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
biotin carboxylase + biotin carboxyl carrier protein (BCCP)
bifunctional protein acetyl-/propionyl-CoA carboxylase subunit alpha AccA
DESCRIPTION:Gene expression[PMID:22307756]
DESCRIPTION:Gene expression[PMID:8610119]
Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)
Pcd (piperideine-6-carboxylate dehydrogenase)
piperideine-6-carboxylic acid dehydrogenase
aryl-sulfate sulphohydrolase (sulfatase)
phosphate transport system transcriptional regulator PhoY
DESCRIPTION:Gene expression[PMID:17097323]
DESCRIPTION:Protein purification and characterization[PMID:15456792]
DESCRIPTION:Protein purification and characterization[PMID:11444966]
Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
acid phosphomonoesterase (phosphomonoesterase) (glycerophosphatase)
DESCRIPTION:Gene expression, mutation analysis[PMID:17360408]
DESCRIPTION:Protein purification and characterization[PMID:20035876]
Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase)
SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
succinate dehydrogenase cytochrome B-556 subunit
SdhD (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
succinate dehydrogenase hydrophobic membrane anchor subunit
110 bp Mycobacterial Interspersed Repetitive Unit,Class III
SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
succinate dehydrogenase iron-sulphur protein subunit
toxin, part of toxin-antitoxin (TA) operon with Rv0300,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv0299
molybdenum cofactor biosynthesis protein MoaC3
Probable pseudogene moaB3,fragment of pterin-4-alpha-carbinolamine dehydratase,equivalent to C-terminus of MT3426|Q8VJ32 pterin-4-alpha-carbinolamine dehydratase from Mycobacterium tuberculosis strain CDC1551
IS6110-14, len: 1355 nt. Insertion sequence IS6110.
28 bp inverted repeat at left end of IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC
similar to insertion sequence element IS986/IS6110 transposase; Probable transposase for insertion element IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation,the sequence UUUUAAAG maybe responsible for such a frameshifting event (see McAdam et al., 1990).
28 bp inverted repeat at right end of IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC
IS1547-2, len: 1086 nt. Region corresponding to Insertion sequence IS1547, positions 1982 3067 in EM_NEW:MTY13470.
DESCRIPTION:Gene expression, mutation analysis[PMID:15321691]
DESCRIPTION:Gene expression[PMID:11506908]
Cofactor: pyridoxal phosphate. Could belong to class-III of pyridoxal-phosphate-dependent aminotransferases.
D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase)
sugar-transport integral membrane protein SugI
N-acetylglucosamine-6-phosphate deacetylase NagA
tryptophanyl-tRNA synthetase TrpS (TRPRS) (tryptophan translase)
NADP Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
homocysteine synthase (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase)
(homoserine O-trans-acetylase) (homoserine transacetylase) (HTA)
Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins
207 bp imperfect direct repeat 1, 199/207 bp identical to second copy at 3769514..3769720
109 bp imperfect direct repeat 1, 95/109 bp identical to second copy at 3769754..3769862
98 bp imperfect direct repeat 1, 82/98 bp identical to the second copy at 3770994..3771091
IS1608', len: 489 nt. Insertion sequence IS1608'.
IS1561', len: 738 nt. Insertion sequence IS1561'.
207 bp imperfect direct repeat 2, 199/207 bp identical to first copy at 3743198..3743404
109 bp imperfect direct repeat 2, 95/109 bp identical to first copy at 3743402..3743510
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
part of toxin-antitoxin (TA) operon with Rv3358
98 bp imperfect direct repeat 2, 82/98 bp identical to the first copy at 3743508..3743605
part of toxin-antitoxin (TA) operon with Rv3357
EXISTENCE:Gene expression[PMID:12705867]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:15158675]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:15719101]
DESCRIPTION:Protein purification and characterization[PMID:18618417]
This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187). Cofactor: Mg2+.
DESCRIPTION:Protein purification and characterization[PMID:21228491]
Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
IS6110-15, len: 1355 nt. Insertion sequence IS6110.
polyprenyl transferase (polyprenyl diphosphate synthase)
toxin, part of toxin-antitoxin (TA) operon with Rv3385c,contains PIN domain
part of toxin-antitoxin (TA) operon with Rv3386c
IS1560-2, len: 1568 nt. Possible Insertion sequence element IS_1560. Second copy in MTCY10G2 from 11273 to 12919.
25 bp inverted repeat at the right end of putative IS1560, TAATTACTAGGACCTGAAAAAGTCG
25 bp inverted repeat at the right end of putative IS1560, TAATTACTAAGACCTGAAAAAGTCG
3-hydroxyacyl-thioester dehydratase HtdY
Possible acrA1,multi functional protein with fatty acyl-CoA reductase activity in C-terminal part.
DESCRIPTION:Gene expression[PMID:7592990]
cyclopropane fatty acid synthase (CFA synthase) (cyclopropane mycolic acid synthase 1)
DESCRIPTION:Protein purification and characterization[PMID:22119138]
glutamine-hydrolyzing (glutamine amidotransferase) (GMP synthetase)
DESCRIPTION:Protein purification and characterization[PMID:15060088]
multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase)
multifunctional dimethylallyltransferase/geranyltranstransferase/farnesylt ranstransferase
part of toxin-antitoxin (TA) operon with Rv3408
toxin, part of toxin-antitoxin (TA) operon with Rv3407,contains PIN domain
DESCRIPTION:Gene expression, mutation analysis[PMID:17651430]
imp dehydrogenase (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD)
DESCRIPTION:Gene expression, mutation analysis[PMID:15375142]
DESCRIPTION:Gene expression, mutation analysis[PMID:19680450]
DESCRIPTION:Protein purification and characterization[PMID:18550384]
redox-responsive transcriptional regulator WhiB3
acetylating enzyme for N-terminal of ribosomal protein S18
ribosomal-protein-alanine acetyltransferase RimI
tRNA threonylcarbamoyladenosine biosynthesis protein
DESCRIPTION:Protein purification and characterization[PMID:11267762]
IS1532, len: 2083 nt. Insertion sequence IS1532.
IS1540, len: 1163 nt. Insertion sequence IS1540.
IS1552, len: 845 nt. Insertion sequence IS1552.
bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase
isomerizing GlmS (hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (glucosamine-6-phosphate synthase)
glucosamine--fructose-6-phosphate aminotransferase
serine proteas (subtilisin-like protease) (subtilase-like) (mycosin-4)
pseudouridylate synthase I (pseudouridine synthase I) (uracil hydrolyase)
RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed RNA nucleotidyltransferase)
DNA-directed RNA polymerase subunit alpha
dTDP-4-keto-6-deoxyglucose 3,5-epimerase (dTDP-L-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase)
AHAS (acetohydroxy-acid synthase large subunit) (ALS)
IS6110-16, len: 1355 nt. Insertion sequence IS6110.
28 bp inverted repeat at left end of IS6110 :TGAACCGCCCCGGCATGTCCGGAGACTC
28 bp inverted repeat at right end of IS6110 :TGAACCGCCCCGGTGAGTCCGGAGACTC
DESCRIPTION:Gene expression, protein purification and characterization[PMID:15939293]
DESCRIPTION:Protein purification and characterization[PMID:12473104]
UDP-forming OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase)
fatty-acid-CoA synthase (fatty-acid-CoA ligase)
long-chain-fatty-acid--CoA ligase FadD17
500 bp perfect direct repeat 2; second copy at 3950830..3951329.
500 bp perfect direct repeat 1; second copy at 3945098..3945597.
DESCRIPTION:Protein purification and characterization[PMID:19234303]
3-ketosteroid-9-alpha-monooxygenase oxygenase subunit
acetaldehyde dehydrogenase [acetylating]
hydratase, 2-oxo-hepta-3-ene-1,7-dioate hydratase or 2-keto-4-pentenoate hydratase
DESCRIPTION:Gene expression[PMID:18031290]
DESCRIPTION:Gene expression, protein purification and characterization[PMID:19846551]
DESCRIPTION:Protein purification and characterization[PMID:19039139]
HTH-type transcriptional regulator KstR2
transaminase A (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase)
DESCRIPTION:Protein purification and characterization[PMID:20448045]
flavin-dependent monooxygenase reductase subunit HsaB
DESCRIPTION:Gene expression, mutation analysis[PMID:19300498]
DESCRIPTION:Protein purification and characterization[PMID:19875455]
4,5-9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
flavin-dependent monooxygenase oxygenase subunit HsaA
3-ketosteroid-9-alpha-hydroxylase reductase subunit
arsenic transport integral membrane protein ArsB
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB
Cysteinyl-tRNA synthetase 1 CysS1 (CYSRS 1) (cysteine translase)
DESCRIPTION:Protein purification and characterization[PMID:20189102]
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD; MEP cytidylyltransferase (MCT)
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
DESCRIPTION:Gene expression, mutation analysis[PMID:19596241]
DESCRIPTION:Gene expression, mutation analysis[PMID:22904282]
RNA polymerase-binding transcription factor CarD
DESCRIPTION:Protein purification and characterization[PMID:22529992]
DESCRIPTION:Protein purification and characterization[PMID:19778963]
DESCRIPTION:Protein purification and characterization[PMID:19917297]
Probable clpC1, ATP-dependent protease ATP-binding subunit
mpr17, fragment of putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, 82-118 nt bands detected by Northern blot in M. bovis BCG Pasteur.; Fragment of putative small regulatory RNA
Lysyl-tRNA synthetase 1 LysS (LysRS 1) (lysine translase)
DESCRIPTION:Protein purification and characterization[PMID:11669627]
pantoate--beta-alanine ligase PanC; pantothenate synthetase (pantoate activating enzyme)
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphok
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
DESCRIPTION:Protein purification and characterization[PMID:10542185]
DHPS 1 (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1)
DESCRIPTION:Gene expression, mutation analysis[PMID:16884108]
ATP-dependentFtsH, cell division protein, membrane-bound protease
18 bp direct repeat 2, GGGTTTGCGATCGCCACG
(24 bp) part of 111 bp direct repeat unit 6,GTGGCGACCCGCTGCACCCGGCTC
111 bp direct repeat unit 5, GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG
18 bp direct repeat 1, GGGTTTGCGATCGCCACG
111 bp direct repeat unit 4, GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG
111 bp direct repeat unit 3, GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG
111 bp direct repeat unit 2, GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG
111 bp direct repeat unit 1, GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG
epoxide hydratase (arene-oxide hydratase)
Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphorylase) (imp diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase)
hypoxanthine-guanine phosphoribosyltransferase
IS1534, len: 2136 nt. Putative Insertion sequence element, IS1534 (IS15C10.2), that resembles IS21; possibly defective.
16 bp inverted repeat at the left end of putative IS element IS1534; GAAAATTGACCAGCTT.
16 bp inverted repeat at the right end of putative IS element IS1534; GAAAATTGACCAGCTT.
IS1553, len: 1293 nt. Putative Insertion sequence element, IS1553.
13 bp inverted repeat at the right end of putative IS element IS1553; GAGTTCGTCGGTG.
13 bp inverted repeat at the left end of putative IS element IS1553; GAGATCGTCGGTG.
thrU, tRNA-Thr, anticodon cgt, length = 73
omega-protein (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (TOPO I)
mpr18, fragment of putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, 82 and 100 nt bands detected by Northern blot in M. bovis BCG Pasteur.; Fragment of putative small regulatory RNA
PE-PGRS family-related protein PE_PGRS60
PE-PGRS family-related protein PE_PGRS61
B11, putative small regulatory RNA (See Arnvig and Young, 2009; DiChiara et al., 2010).
MTS2823, putative small regulatory RNA (See Arnvig et al., 2011), 5'-end mapped by RLM-RACE, 3'-end not mapped, ~300 bp and ~250 bp bands detected by Northern blot.
dipeptide ABC transporter ATP-binding protein DppD
dipeptide ABC transporter substrate-binding lipoprotein DppA
DESCRIPTION:Protein purification and characterization[PMID:21896569]
Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--CoAligase) (acetyl-CoAsynthase)
DESCRIPTION:Protein purification and characterization[PMID:20947023]
thiol-disulfide interchange related protein
membrane-anchored thioredoxin-like protein
Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic))
DESCRIPTION:Protein purification and characterization[PMID:16267303]
DESCRIPTION:Protein purification and characterization[PMID:17302817]
membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase)
proY, tRNA-Pro, anticodon cgg, length = 74
anti-sigma factor antagonist (regulator of sigma F B)
125 bp Mycobacterial Interspersed Repetitive Unit,Class III.
ATP:glycerol 3-phosphotransferase (glycerokinase) (GK)
toxin, part of toxin-antitoxin (TA) operon with Rv3697A, contains PIN domain
part of toxin-antitoxin (TA) operon with Rv3697c
pyridoxal-phosphate-dependent protein EgtE
histidine-specific methyltransferase EtgD
GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase)
DESCRIPTION:Protein purification and characterization[PMID:15752328]
Asd (ASA dehydrogenase) (ASADH) (aspartic semialdehyde dehydrogenase) (L-aspartate-beta-semialdehyde dehydrogenase)
EXISTENCE:Protein crystalography[PMID:21393848]
Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha); and aspartokinase beta subunit (Ask-beta)]
DESCRIPTION:Protein purification and characterization[PMID:11914056]
alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS)
Possible 4.5S RNA in signal recognition particle (small cytoplasmic RNA) (SC-RNA)
C8, possible 4.5S RNA (See Arnvig and Young, 2009; DiChiara et al., 2010), part of signal recognition particle with protein Ffh. Alternate 3'-ends at positions 4168212 and 4168224.
serV, tRNA-Ser, anticodon gga, length = 86
AraC/XylS family transcriptional regulator
serX, tRNA-Ser, anticodon cga, length = 87. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
glycine betaine/carnitine/choline/L-proline ABC transporter permease ProZ
glycine betaine/carnitine/choline/L-proline ABC transporter permease ProW
glycine betaine/carnitine/choline/L-proline ABC transporter ATP-binding protein ProV
glycine betaine/carnitine/choline/L-proline ABC transporter substrate-binding lipoprotein ProX
DESCRIPTION:Gene expression[PMID:12595424]
DESCRIPTION:Protein purification and characterization[PMID:19962420]
two component transcriptional regulator TcrX
argU, tRNA-Arg, anticodon acg, length = 73
serT, tRNA-Ser, anticodon gct, length = 89
imidazole acetol-phosphate transaminase (imidazolylacetolphosphate aminotransferase)
serU, tRNA-Ser, anticodon tga, length = 87
O-antigen/lipopolysaccharide ABC transporter ATP-binding protein RfbE
DESCRIPTION:Gene expression, protein purification and characterization[PMID:16952951]
DESCRIPTION:Protein purification and characterization[PMID:18248822]
O-antigen/lipopolysaccharide ABC transporter permease RfbD
DESCRIPTION:Protein purification and characterization[PMID:16291675]
decaprenylphosphoryl-beta-D-ribose oxidase
decaprenylphosphoryl-D-2-keto erythropentose reductase
DESCRIPTION:Protein purification and characterization[PMID:16595677]
DESCRIPTION:Gene expression, mutation analysis[PMID:9142129]
EmbC (arabinosylindolylacetylinositol synthase)
EmbA (arabinosylindolylacetylinositol synthase)
EmbB (arabinosylindolylacetylinositol synthase)
IS1557-3, len: 1332 nt. Insertion sequence IS1557.
propionyl-CoA carboxylase subunit beta AccD
long-chain-fatty-acid--AMP ligase FadD32
MPT51/MPB51 antigen 85 complex C (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C)
DESCRIPTION:Gene expression, protein purification and characterization[PMID:21819455]
secreted antigen 85-a FbpA; mycolyl transferase 85A (fibronectin-binding protein A) (antigen 85 complex A)
diacylglycerol acyltransferase/mycolyltransferase Ag85A
DESCRIPTION:Gene expression, mutation analysis[PMID:17387176]
terminal beta-(1->2)-arabinofuranosyltransferase
DESCRIPTION:Gene expression, protein purification and characterization[PMID:15878857]
DPPR synthase (decaprenyl-phosphate 5-phosphoribosyltransferase)
decaprenyl-phosphate phosphoribosyltransferase
decaprenylphosphoryl-5-phosphoribose phosphatase
DESCRIPTION:Gene expression[PMID:11304545]
DESCRIPTION:Protein purification and characterization[PMID:16704275]
DESCRIPTION:Gene expression[PMID:9692181]
Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme)
Exported repetitive protein precursor PirG
DESCRIPTION:Gene expression, protein purification and characterization[PMID:17592143]
integral membrane transport protein MmpL8
DESCRIPTION:Gene expression, mutation analysis[PMID:17259623]
Polyketide synthase-associated protein A1
DESCRIPTION:Gene expression, mutation analysis[PMID:11278910]
phthioceranic/hydroxyphthioceranic acid synthase
DESCRIPTION:Gene expression, mutation analysis[PMID:17768256]
long-chain-fatty-acid--CoA ligase FadD23
IS1537, len: 1873 nt. Insertion sequence IS1537.
SERYL-tRNA synthetase SerS (SERRS) (serine translase)
phosphoglyceromutase (phosphoglycerate phosphomutase)
DESCRIPTION:Protein purification and characterization[PMID:15753077]
EXISTENCE:Protein crystalography[PMID:21139218]
glycerophosphoryl diester phosphodiesterase
ncrMT3949, fragment of putative small regulatory RNA (See Pelly et al., 2012), cloned from M. tuberculosis CDC1551; supported by RNA-seq in H37Rv (unpublished data).; Fragment of putative small regulatory RNA
MTS2975, putative small regulatory RNA (See Arnvig et al., 2011), ends not mapped, ~100 bp band detected by Northern blot.
DESCRIPTION:Gene expression[PMID:1904126]
DESCRIPTION:Gene expression, mutation analysis[PMID:10944230]
DESCRIPTION:Protein purification and characterization[PMID:11823459]
NADH-dependent L-glutamate synthase (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH)) (GLTS beta chain) (NADPH-GOGAT)
ferredoxin-dependent L-glutamate synthase (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH))(NADPH-GOGAT)
DESCRIPTION:Gene expression, mutation analysis[PMID:16368961]
Member of the Mycobacterium tuberculosis PPE family. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927). Predicted possible vaccine candidate (See Zvi et al., 2008).
51 bp imperfect direct repeat 1,GAACCGGCCGCATCTAAACCACCCACACCCCCCATGCCCATCGCCGGACCC
51 bp imperfect direct repeat 2,GAACCGGCCCCACCCAAACCACCCACACCCCCCATGCCCATCGCCGGACCC
51 bp imperfect direct repeat 3,GAACCGGCCCCACCCAAACCACCCACACCTCCGATGCCCATCGCCGGACCT
MycP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1)
MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2)
ESX-2 secretion-associated protein EspG2
ESX-2 type VII secretion system protein EccC
DESCRIPTION:Gene expression, mutation analysis[PMID:17028284]
DESCRIPTION:Protein purification and characterization[PMID:7591163]
DESCRIPTION:Gene expression, mutation analysis, protein purification and characterization[PMID:17238915]
16S rRNA (guanine(527)-N(7))-methyltransferase RsmG
membrane protein insertion efficiency factor
RnpA (RNaseP protein) (RNase P protein) (protein C5)