Sugiyamaella lignohabitans strain CBS 10342 chromosome B, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Trichomonascaceae; Sugiyamaella.
Complete genome sequence and transcriptome regulation of the pentose utilising yeast Sugiyamaella lignohabitans
Submitted (25-OCT-2016) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (18-FEB-2016) Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, Vienna 1190, Austria
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP014503.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
similar to AA sequence:KEGG_Orthology:K14574
similar to AA sequence:KEGG_Orthology:K11877
similar to AA sequence:KEGG_Orthology:K08968
1-phosphatidylinositol-4-phosphate 5-kinase
similar to AA sequence:KEGG_Orthology:K00889
Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01192
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 10072385]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IMP] [PMID 10072385]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0048026 - positive regulation of mRNA splicing, via spliceosome [Evidence IMP] [PMID 10983980]
similar to AA sequence:KEGG_Orthology:K11681
3',5'-cyclic-nucleotide phosphodiesterase PDE2
similar to AA sequence:KEGG_Orthology:K01120
High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IDA] [PMID 3025832]; GO_function: GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IMP] [PMID 8391474]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 18469165]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11445562]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20007605]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12858164]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16429156]; GO_function: GO:0070336 - flap-structured DNA binding [Evidence IDA] [PMID 20007605]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 12858164]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 16429156]; GO_process: GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP,IPI] [PMID 18469165]; GO_process: GO:0032079 - positive regulation of endodeoxyribonuclease activity [Evidence IDA,IPI] [PMID 20007605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1); GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA,IMP] [PMID 20007951]; GO_function: GO:0042393 - histone binding [Evidence IDA,IPI] [PMID 16157874]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 18662540]; GO_function: GO:0042393 - histone binding [Evidence IDA,IMP] [PMID 20007951]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IGI] [PMID 18662540]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IMP] [PMID 18708354]; GO_process: GO:0070869 - heterochromatin assembly involved in chromatin silencing [Evidence IGI,IMP] [PMID 17410207]; GO_process: GO:0070869 - heterochromatin assembly involved in chromatin silencing [Evidence IGI] [PMID 20007951]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 19683497]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 18708354]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]
type 1 serine/threonine-protein phosphatase catalytic subunit GLC7
similar to AA sequence:KEGG_Orthology:K06269
Type 1 serine/threonine protein phosphatase catalytic subunit; cleavage and polyadenylation factor (CPF) component; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11412094]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 19948764]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 10747092]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11412094]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23418575]; GO_component: GO:0000164 - protein phosphatase type 1 complex [Evidence IDA] [PMID 8289829]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 10747092]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 1660885]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 19884341]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IGI,IMP] [PMID 19884341]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 9584086]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007114 - cell budding [Evidence IMP] [PMID 10639337]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 11973298]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 10072383]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 24413056]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IMP] [PMID 1660885]; GO_process: GO:0016576 - histone dephosphorylation [Evidence IMP] [PMID 10975519]; GO_process: GO:0016576 - histone dephosphorylation [Evidence IDA,IMP] [PMID 19884341]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IPI] [PMID 8754819]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IMP] [PMID 10072380]; GO_process: GO:0035307 - positive regulation of protein dephosphorylation [Evidence IMP] [PMID 23418575]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 1660885]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19948764]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0006109 - regulation of carbohydrate metabolic process [Evidence IGI,IPI] [PMID 12167649]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 10072380]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 7891699]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 8164671]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 9584086]; GO_process: GO:0000903 - regulation of cell shape during vegetative growth phase [Evidence IGI] [PMID 12477789]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 23418575]; GO_process: GO:0031297 - replication fork processing [Evidence IMP] [PMID 19884341]; GO_process: GO:0009408 - response to heat [Evidence IMP,IPI] [PMID 10207049]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IPI] [PMID 12819204]; GO_process: GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled [Evidence IPI] [PMID 12819204]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16533810]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA] [PMID 16533810]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 21278159]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16533810]; GO_process: GO:0061420 - regulation of transcription from RNA polymerase II promoter in response to biotin starvation [Evidence IMP] [PMID 16533810]; GO_process: GO:0061420 - regulation of transcription from RNA polymerase II promoter in response to biotin starvation [Evidence IMP] [PMID 21278159]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K18170
Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 20404342]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0044183 - protein binding involved in protein folding [Evidence IMP,IPI] [PMID 22927643]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 21807901]
similar to AA sequence:KEGG_Orthology:K02355
Mitochondrial elongation factor involved in translational elongation; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 19716793]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 21414316]; GO_process: GO:0032543 - mitochondrial translation [Evidence ISS] [PMID 19716793]; GO_process: GO:0051881 - regulation of mitochondrial membrane potential [Evidence IMP] [PMID 21414316]; GO_process: GO:0032790 - ribosome disassembly [Evidence ISS] [PMID 19716793]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12819
similar to AA sequence:KEGG_Orthology:K11662
Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11011149]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16299513]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IMP] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06675
Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12719426]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11864994]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IMP] [PMID 24062159]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IC] [PMID 10811823]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IC] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 10811823]; GO_process: GO:0070550 - rDNA condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IC] [PMID 10811823]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
similar to AA sequence:KEGG_Orthology:K06127
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9083048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043334 - 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Evidence IMP,ISS] [PMID 9083049]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9083049]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9083048]
proteasome core particle subunit alpha 3
similar to AA sequence:KEGG_Orthology:K02728
Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0080129 - proteasome core complex assembly [Evidence IMP] [PMID 14739934]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12972564]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11854408]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12972564]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 12972564]; GO_process: GO:0007114 - cell budding [Evidence IGI,IMP] [PMID 11854408]; GO_process: GO:0000902 - cell morphogenesis [Evidence IGI,IMP] [PMID 11854408]
similar to AA sequence:KEGG_Orthology:K14563
Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11932453]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 2686980]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:1990259 - histone-glutamine methyltransferase activity [Evidence IMP] [PMID 24352239]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IDA,IMP] [PMID 12215523]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000494 - box C/D snoRNA 3'-end processing [Evidence IMP] [PMID 10733567]; GO_process: GO:0000494 - box C/D snoRNA 3'-end processing [Evidence IMP] [PMID 15167896]; GO_process: GO:1990258 - histone glutamine methylation [Evidence IDA,IMP] [PMID 24352239]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IDA,IMP] [PMID 12215523]; GO_process: GO:0031167 - rRNA methylation [Evidence IMP] [PMID 8431947]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 1825809]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0043144 - snoRNA processing [Evidence IMP] [PMID 1825809]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02880
Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09313
Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IGI] [PMID 12429822]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IGI] [PMID 12429822]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
nucleoside transmembrane transporter FUN26
similar to AA sequence:KEGG_Orthology:K15014
similar to AA sequence:KEGG_Orthology:K11405
Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23222640]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 11410665]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 11410665]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IDA] [PMID 11410665]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 11410665]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IPI] [PMID 11410665]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 8913743]; GO_process: GO:0007088 - regulation of mitosis [Evidence IMP] [PMID 8913743]
similar to AA sequence:KEGG_Orthology:K03448
Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IGI,ISS] [PMID 10373490]; GO_function: GO:0015233 - pantothenate transmembrane transporter activity [Evidence IGI,IMP] [PMID 10373490]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 15020461]; GO_process: GO:0015887 - pantothenate transmembrane transport [Evidence IGI,IMP] [PMID 10373490]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Specific translational activator for the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs); GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 18039654]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 9692914]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9692914]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0045182 - translation regulator activity [Evidence IGI] [PMID 7664742]; GO_process: GO:0016070 - RNA metabolic process [Evidence IMP] [PMID 7664742]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 7664742]; GO_process: GO:0097034 - mitochondrial respiratory chain complex IV biogenesis [Evidence IMP] [PMID 7664742]; GO_process: GO:0070134 - positive regulation of mitochondrial translational initiation [Evidence IMP] [PMID 18039654]; GO_process: GO:0070134 - positive regulation of mitochondrial translational initiation [Evidence IMP] [PMID 7664742]
similar to AA sequence:KEGG_Orthology:K12948
Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 1846444]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 8910564]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IMP] [PMID 9148930]; GO_function: GO:0008233 - peptidase activity [Evidence IMP] [PMID 9148931]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 9148931]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 9148930]; GO_process: GO:0006465 - signal peptide processing [Evidence IDA,IMP] [PMID 9148931]
succinate-semialdehyde dehydrogenase (NAD(P)(+))
similar to AA sequence:KEGG_Orthology:K00135
Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IEA,IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP,ISS] [PMID 11031268]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 3888627]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEA,IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEP,IMP,ISS] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0006540 - glutamate decarboxylation to succinate [Evidence IGI,IMP,ISS] [PMID 11031268]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11979
similar to AA sequence:KEGG_Orthology:K10958
similar to AA sequence:KEGG_Orthology:K02540
Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10783164]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 22564307]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:1902450 - negative regulation of ATP-dependent DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
RNA polymerase III-inhibiting protein MAF1
phosphoprotein phosphatase PP4 catalytic subunit PPH3
Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 20951350]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA,IMP] [PMID 16299494]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA] [PMID 17517611]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,IMP] [PMID 16299494]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 7941742]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IGI] [PMID 21135129]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 16299494]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 17517611]; GO_process: GO:1902660 - negative regulation of glucose mediated signaling pathway [Evidence IMP] [PMID 24277933]; GO_process: GO:0051173 - positive regulation of nitrogen compound metabolic process [Evidence IMP] [PMID 10940301]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA,IMP] [PMID 16299494]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 7941742]; GO_process: GO:0072462 - signal transduction involved in meiotic recombination checkpoint [Evidence IMP] [PMID 20951350]
Membrane hypothetical protein; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 17005914]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI] [PMID 17005914]
similar to AA sequence:KEGG_Orthology:K01507
Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IDA] [PMID 8224193]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IC] [PMID 8224193]
phosphoribosylanthranilate isomerase TRP1
similar to AA sequence:KEGG_Orthology:K01817
Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004640 - phosphoribosylanthranilate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004640 - phosphoribosylanthranilate isomerase activity [Evidence IDA] [PMID 3286643]; GO_function: GO:0004640 - phosphoribosylanthranilate isomerase activity [Evidence IMP] [PMID 348687]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IDA] [PMID 3286643]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 348687]; GO_process: GO:0006568 - tryptophan metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07566
Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003725 - double-stranded RNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0043047 - single-stranded telomeric DNA binding [Evidence IDA] [PMID 19369944]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 19884342]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 19369944]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IDA] [PMID 23620299]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 19287007]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 21183954]
Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1
similar to AA sequence:KEGG_Orthology:K01537
High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen appears to be required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 24124599]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 9092527]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IDA,IMP] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IMP] [PMID 1379856]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0015410 - manganese-transporting ATPase activity [Evidence IDA] [PMID 10801856]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA,IMP] [PMID 10545175]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI] [PMID 23569283]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 1379856]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006828 - manganese ion transport [Evidence IDA] [PMID 10801856]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00380
Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide; GO_component: GO:0009337 - sulfite reductase complex (NADPH) [Evidence IDA] [PMID 6751400]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016903 - oxidoreductase activity, acting on the aldehyde or oxo group of donors [Evidence IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IDA] [PMID 6751400]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 19236486]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 7928966]
glucose-induced degradation complex subunit VID28
GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 12586695]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12586695]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 15358789]
Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation of conserved residues leads to defects in endocytic recycling and a block in sporulation/meiosis; mutations in the human homolog cause the spondyloepiphyseal dysplasia; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 9564032]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11560
Mitochondrial distribution and morphology protein 34
similar to AA sequence:KEGG_Orthology:K17775
similar to AA sequence:KEGG_Orthology:K10661
Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11641273]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11641273]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 17051211]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11641273]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11641273]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15331
tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IEA]; GO_function: GO:0030697 - S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0051908 - double-stranded DNA 5'-3' exodeoxyribonuclease activity [Evidence IDA] [PMID 17205207]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0000014 - single-stranded DNA endodeoxyribonuclease activity [Evidence IDA] [PMID 17205207]; GO_function: GO:0030696 - tRNA (m5U54) methyltransferase activity [Evidence IDA,IMP] [PMID 10864043]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI,IMP] [PMID 17205207]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI,IMP] [PMID 17534700]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 10864043]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
Bifunctional purine biosynthesis protein purH
similar to AA sequence:KEGG_Orthology:K01127
similar to AA sequence:KEGG_Orthology:K14708
High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 7616962]; GO_function: GO:0008271 - secondary active sulfate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015116 - sulfate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015116 - sulfate transmembrane transporter activity [Evidence IGI,IMP] [PMID 7616962]; GO_process: GO:1902358 - sulfate transmembrane transport [Evidence IEA]; GO_process: GO:0008272 - sulfate transport [Evidence IEA]; GO_process: GO:0008272 - sulfate transport [Evidence IGI,IMP] [PMID 7616962]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7616962]; GO_process: GO:0006810 - transport [Evidence IEA]
Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 17515604]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IDA] [PMID 17515604]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IDA] [PMID 17515604]
Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 2072919]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015079 - potassium ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015079 - potassium ion transmembrane transporter activity [Evidence IDA,ISS] [PMID 2072919]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IDA] [PMID 2072919]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0042391 - regulation of membrane potential [Evidence IMP] [PMID 21424545]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
mitogen-activated protein kinase kinase PBS2
similar to AA sequence:KEGG_Orthology:K11227
hypothetical protein; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K09486
Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 8654361]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 8887673]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 19759005]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA] [PMID 14704430]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP,IPI] [PMID 10409721]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI,IMP] [PMID 8654361]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI,IMP] [PMID 8887673]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 8654361]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 8887673]; GO_process: GO:0006986 - response to unfolded protein [Evidence IGI,IMP] [PMID 8654361]; GO_process: GO:0006986 - response to unfolded protein [Evidence IGI,IMP] [PMID 8887673]
bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase
similar to AA sequence:KEGG_Orthology:K11541
Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11015727]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 11921093]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0004070 - aspartate carbamoyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004070 - aspartate carbamoyltransferase activity [Evidence IDA] [PMID 10446140]; GO_function: GO:0004070 - aspartate carbamoyltransferase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 5776390]; GO_function: GO:0016743 - carboxyl- or carbamoyltransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IDA] [PMID 181668]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0070409 - carbamoyl phosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006543 - glutamine catabolic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IDA] [PMID 5651325]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0045984 - negative regulation of pyrimidine nucleobase metabolic process [Evidence IDA] [PMID 5651325]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12837
similar to AA sequence:KEGG_Orthology:K17302
Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP; GO_component: GO:0030126 - COPI vesicle coat [Evidence IGI,ISS] [PMID 7929113]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7929113]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP,IPI] [PMID 17101773]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8001155]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K07734
Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 2203793]; GO_function: GO:1901235 - (R)-carnitine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 2203793]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_function: GO:0034228 - ethanolamine transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_process: GO:1900749 - (R)-carnitine transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015871 - choline transport [Evidence IMP] [PMID 2203793]; GO_process: GO:0015871 - choline transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0034229 - ethanolamine transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0031460 - glycine betaine transport [Evidence IMP] [PMID 16487344]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18408053]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18408053]; GO_function: GO:0008420 - CTD phosphatase activity [Evidence IDA] [PMID 19394294]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA,IMP] [PMID 19394294]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI,IMP,IPI] [PMID 18408053]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08139
hypothetical protein; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 10628972]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042149 - cellular response to glucose starvation [Evidence IMP,IPI] [PMID 10628972]
similar to AA sequence:KEGG_Orthology:K14298
RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15210706]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 8970155]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9725905]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 8970155]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:2000728 - regulation of mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 15210706]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20098417]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019208 - phosphatase regulator activity [Evidence IMP] [PMID 23861665]; GO_process: GO:0048255 - mRNA stabilization [Evidence IGI] [PMID 20471941]
mitochondrial 37S ribosomal protein MRPS16
similar to AA sequence:KEGG_Orthology:K02959
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17065
Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 11038182]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 16968746]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 16186251]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IDA] [PMID 16186251]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 16186251]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 18298044]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP] [PMID 10559943]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI] [PMID 17336903]; GO_process: GO:0051646 - mitochondrion localization [Evidence IGI] [PMID 23341591]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 9786946]; GO_process: GO:0016559 - peroxisome fission [Evidence IGI] [PMID 18445678]; GO_process: GO:0007031 - peroxisome organization [Evidence IGI,IMP] [PMID 16968746]; GO_process: GO:0051260 - protein homooligomerization [Evidence IDA] [PMID 16186251]
hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11309
similar to AA sequence:KEGG_Orthology:K02738
Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9207060]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9312134]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
translation initiation factor eIF3d Moe1
similar to AA sequence:KEGG_Orthology:K03251
similar to AA sequence:KEGG_Orthology:K12666
Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IEA]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IDA] [PMID 9015380]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA] [PMID 9015380]; GO_process: GO:0018279 - protein N-linked glycosylation via asparagine [Evidence IPI] [PMID 9988747]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K02605
Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 9153234]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03671
Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8603912]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IPI] [PMID 9657146]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IDA] [PMID 19362171]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence ISS] [PMID 1988444]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IDA] [PMID 9813082]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence TAS] [PMID 11169096]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence ISS] [PMID 1988444]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0080058 - protein deglutathionylation [Evidence IDA,IGI] [PMID 20074363]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA] [PMID 9813082]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 9657146]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 8603912]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 9015301]
similar to AA sequence:KEGG_Orthology:K01694
Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence IEA,IEA]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence IDA] [PMID 391563]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence ISO] [PMID 6276387]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence IDA] [PMID 6342605]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]; GO_process: GO:0006568 - tryptophan metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01228
Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8576053]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004573 - mannosyl-oligosaccharide glucosidase activity [Evidence IEA,IEA]; GO_function: GO:0004573 - mannosyl-oligosaccharide glucosidase activity [Evidence IDA] [PMID 14680956]; GO_function: GO:0004573 - mannosyl-oligosaccharide glucosidase activity [Evidence IMP,ISS] [PMID 9430631]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 9430631]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009311 - oligosaccharide metabolic process [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 9363442]
Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 23169667]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015326 - cationic amino acid transmembrane transporter activity [Evidence IMP,ISA] [PMID 23169667]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0034488 - basic amino acid transmembrane export from vacuole [Evidence IMP,ISA] [PMID 23169667]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02936
Ribosomal 60S subunit protein L8B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA,IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 22893726]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to Pantoea sp. aB, conserved hypothetical protein (NCBI: ZP_07377486.1)
similar to AA sequence:KEGG_Orthology:K02938
Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06674
Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0000796 - condensin complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003680 - AT DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12719426]; GO_function: GO:0000217 - DNA secondary structure binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16055730]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IC] [PMID 10811823]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IC] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 10811823]; GO_process: GO:0070550 - rDNA condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IC] [PMID 10811823]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
ubiquinol--cytochrome-c reductase subunit 6
similar to AA sequence:KEGG_Orthology:K00416
Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IMP] [PMID 8288589]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8288589]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IMP] [PMID 8288589]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14684
similar to AA sequence:KEGG_Orthology:K00604
Methionyl-tRNA formyltransferase; catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 5277072]; GO_function: GO:0016742 - hydroxymethyl-, formyl- and related transferase activity [Evidence IEA]; GO_function: GO:0004479 - methionyl-tRNA formyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004479 - methionyl-tRNA formyltransferase activity [Evidence IMP] [PMID 10781559]; GO_function: GO:0004479 - methionyl-tRNA formyltransferase activity [Evidence IDA] [PMID 12549912]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0071951 - conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [Evidence IEA]; GO_process: GO:0071951 - conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [Evidence IMP] [PMID 10781559]; GO_process: GO:0071951 - conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [Evidence IDA] [PMID 12549912]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K19525
similar to AA sequence:KEGG_Orthology:K08675
ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8146662]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8276800]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8146662]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8276800]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0070361 - mitochondrial light strand promoter anti-sense binding [Evidence IBA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IBA]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IBA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IBA,IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IGI] [PMID 8810243]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IEA,IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 16336126]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IGI,IMP] [PMID 7957078]; GO_process: GO:0007005 - mitochondrion organization [Evidence IBA]; GO_process: GO:0070407 - oxidation-dependent protein catabolic process [Evidence IBA,IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0051260 - protein homooligomerization [Evidence IBA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0090296 - regulation of mitochondrial DNA replication [Evidence IEA]; GO_process: GO:0001666 - response to hypoxia [Evidence IBA]
Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 17178117]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IPI] [PMID 11943201]; GO_process: GO:0008150 - biological_process [Evidence ND]
Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11427713]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11781332]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20035756]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005227 - calcium activated cation channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IDA] [PMID 11781332]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005267 - potassium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005272 - sodium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IDA] [PMID 1700419]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11427713]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11781332]; GO_process: GO:0006811 - ion transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00311
Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IPI] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004174 - electron-transferring-flavoprotein dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
nicotinamide-nucleotide adenylyltransferase NMA1
similar to AA sequence:KEGG_Orthology:K06210
Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000309 - nicotinamide-nucleotide adenylyltransferase activity [Evidence IEA]; GO_function: GO:0000309 - nicotinamide-nucleotide adenylyltransferase activity [Evidence IDA] [PMID 10428462]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA] [PMID 10428462]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08150
similar to AA sequence:KEGG_Orthology:K12571
Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; GO_component: GO:0031251 - PAN complex [Evidence IDA] [PMID 8816488]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004535 - poly(A)-specific ribonuclease activity [Evidence IEA]; GO_function: GO:0004535 - poly(A)-specific ribonuclease activity [Evidence IMP] [PMID 8550599]; GO_process: GO:0090503 - RNA phosphodiester bond hydrolysis, exonucleolytic [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP,IPI] [PMID 8550599]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IMP,IPI] [PMID 8550599]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IPI] [PMID 11953437]
similar to AA sequence:KEGG_Orthology:K11204
Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IBA]; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 2184310]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004357 - glutamate-cysteine ligase activity [Evidence IEA,IEA]; GO_function: GO:0004357 - glutamate-cysteine ligase activity [Evidence IDA] [PMID 1687097]; GO_function: GO:0004357 - glutamate-cysteine ligase activity [Evidence IMP] [PMID 2184310]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IDA] [PMID 1687097]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IMP] [PMID 8768524]; GO_process: GO:0046686 - response to cadmium ion [Evidence IDA] [PMID 10921921]; GO_process: GO:0042542 - response to hydrogen peroxide [Evidence IMP] [PMID 7615092]
Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9427760]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9427760]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IPI] [PMID 18708352]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IC] [PMID 18708352]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IC] [PMID 9427760]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10850718]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17005992]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18708352]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9427760]; GO_process: GO:0035952 - negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17005992]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]
Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12086626]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008134 - transcription factor binding [Evidence IDA] [PMID 12086626]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IMP] [PMID 12086626]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 19417103]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 14736892]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 14736892]; GO_component: GO:0000306 - extrinsic component of vacuolar membrane [Evidence IDA] [PMID 14736892]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 17560372]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 14736892]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 14736892]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IGI] [PMID 10931309]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 14736892]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 17298473]
Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 7720726]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9624182]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 7720726]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0000149 - SNARE binding [Evidence IPI] [PMID 16769821]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP,IPI] [PMID 11432826]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 10545112]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI] [PMID 9335586]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 7720726]; GO_process: GO:0048210 - Golgi vesicle fusion to target membrane [Evidence IMP] [PMID 9650782]; GO_process: GO:0035543 - positive regulation of SNARE complex assembly [Evidence IMP] [PMID 11432826]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 7628704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 7628704]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 9650782]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12883
Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif; GO_component: GO:0000243 - commitment complex [Evidence IDA] [PMID 8682299]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IDA] [PMID 8811086]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0000339 - RNA cap binding [Evidence IEA]; GO_function: GO:0000339 - RNA cap binding [Evidence IDA,ISS] [PMID 8682299]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0045292 - mRNA cis splicing, via spliceosome [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 8682299]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Cytosolic J-domain-containing protein; required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9679141]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 9679141]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 9679141]
Uric acid-xanthine permease (UAPA transporter)
Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 9032248]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence ISA] [PMID 8212900]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IPI] [PMID 9032248]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]
Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10401
Kinesin-related antiparallel sliding motor protein involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; also inhibits spindle elongation and promotes spindle disassembly in late anaphase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 9693366]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 9693366]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906145]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906148]; GO_function: GO:0070463 - tubulin-dependent ATPase activity [Evidence IDA] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 23851487]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 9813090]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IGI,IMP] [PMID 10525539]; GO_process: GO:0031115 - negative regulation of microtubule polymerization [Evidence IMP] [PMID 24616221]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 9693366]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906145]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906148]; GO_process: GO:0032888 - regulation of mitotic spindle elongation [Evidence IMP] [PMID 24616221]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 23851487]
similar to AA sequence:KEGG_Orthology:K03217
Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 22513091]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 22513091]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 14657017]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 19783770]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005216 - ion channel activity [Evidence IDA] [PMID 22829595]; GO_function: GO:0032977 - membrane insertase activity [Evidence IMP] [PMID 9285818]; GO_function: GO:0032977 - membrane insertase activity [Evidence IMP] [PMID 9428747]; GO_function: GO:0097177 - mitochondrial ribosome binding [Evidence IDA] [PMID 14657018]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 18826960]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 17344477]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IMP] [PMID 22846909]; GO_process: GO:0051205 - protein insertion into membrane [Evidence IEA]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 17452441]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 9285818]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 9428747]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP,IPI] [PMID 9482871]
Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 12135984]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016298 - lipase activity [Evidence IDA] [PMID 18199283]; GO_function: GO:0016298 - lipase activity [Evidence ISS] [PMID 9200815]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA] [PMID 24187129]; GO_process: GO:0007031 - peroxisome organization [Evidence IEP] [PMID 12135984]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI] [PMID 24187129]
One of three possible beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain; GAL83 has a paralog, SIP2, that arose from the whole genome duplication; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA] [PMID 12393914]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 7813428]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 9121458]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17237508]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 17237508]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11331606]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17237508]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IGI] [PMID 10990457]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 7813428]; GO_process: GO:0007155 - cell adhesion [Evidence IMP] [PMID 12556493]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12556493]; GO_process: GO:0006468 - protein phosphorylation [Evidence IGI] [PMID 10990457]; GO_process: GO:0043254 - regulation of protein complex assembly [Evidence IGI] [PMID 9121458]; GO_process: GO:0007165 - signal transduction [Evidence IGI] [PMID 10990457]
Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 17914457]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17914457]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 17914457]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17914457]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 7962098]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 7579704]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IC] [PMID 7579704]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI,IMP] [PMID 17914457]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
Putative acyltransferase with similarity to Eeb1p and Eht1p; has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence ISS] [PMID 16361250]; GO_process: GO:0051792 - medium-chain fatty acid biosynthetic process [Evidence IGI] [PMID 16361250]
succinate--CoA ligase (GDP-forming) subunit alpha
similar to AA sequence:KEGG_Orthology:K01648
Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003878 - ATP citrate synthase activity [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IDA,IMP,ISS] [PMID 9874242]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence IDA] [PMID 9874242]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
similar to AA sequence:KEGG_Orthology:K16186
Putative GTP binding protein; negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD; GO_component: GO:0034448 - EGO complex [Evidence IPI] [PMID 15989961]; GO_component: GO:0034448 - EGO complex [Evidence IDA] [PMID 16732272]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 10388807]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 16143306]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10388807]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11073942]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15989961]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 16732272]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 18258182]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10388807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11073942]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 10388807]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0016237 - microautophagy [Evidence IMP] [PMID 15989961]; GO_process: GO:0032008 - positive regulation of TOR signaling [Evidence IGI,IMP] [PMID 19748353]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 18258182]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15450
tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA,IMP] [PMID 16642040]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 16642040]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
similar to AA sequence:KEGG_Orthology:K01876
Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16113655]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16113655]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12888345]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IDA] [PMID 8263943]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006422 - aspartyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006422 - aspartyl-tRNA aminoacylation [Evidence IDA] [PMID 8263943]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
Ras family guanine nucleotide exchange factor CDC25
similar to AA sequence:KEGG_Orthology:K03099
similar to AA sequence:KEGG_Orthology:K04569
Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9295278]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11500508]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18977757]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016532 - superoxide dismutase copper chaperone activity [Evidence IGI,IMP,ISS] [PMID 9295278]; GO_function: GO:0008270 - zinc ion binding [Evidence IBA]; GO_process: GO:0015680 - intracellular copper ion transport [Evidence IMP,ISS] [PMID 9295278]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0019430 - removal of superoxide radicals [Evidence IBA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]
Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077113]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9880327]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0000042 - protein targeting to Golgi [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 9880327]
similar to AA sequence:KEGG_Orthology:K01452
Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall; GO_component: GO:0005631 - chitosan layer of spore wall [Evidence ISS] [PMID 8940152]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IDA,ISS] [PMID 8940152]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8940152]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2
similar to AA sequence:KEGG_Orthology:K00062
NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0047816 - D-arabinose 1-dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0045290 - D-arabinose 1-dehydrogenase [NAD(P)+] activity [Evidence IDA,IMP] [PMID 17097644]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0070485 - dehydro-D-arabinono-1,4-lactone biosynthetic process [Evidence IMP] [PMID 17097644]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IMP] [PMID 21347278]
similar to AA sequence:KEGG_Orthology:K03347
Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 19882662]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346239]; GO_component: GO:0031461 - cullin-RING ubiquitin ligase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IPI] [PMID 16421250]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 9499404]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 10385629]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 8943317]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 9736614]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
Meiosis-specific protein required for spore wall formation; localizes to prospore membrane (PSM) and is required for PSM closure during sporulation; mediates PSM size; interacts with Spo1p and Vps13p and recruits Vps13p to the PSM during sporulation; mutants exhibit reduction in PSM PtdIns-phosphate pools; dispensable for both nuclear divisions during meiosis; contains two PH domains; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24036347]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 22611022]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IEP,IMP] [PMID 9784122]; GO_process: GO:1902657 - protein localization to prospore membrane [Evidence IDA] [PMID 24036347]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02137
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005753 - mitochondrial proton-transporting ATP synthase complex [Evidence IDA] [PMID 10066811]; GO_component: GO:0000274 - mitochondrial proton-transporting ATP synthase, stator stalk [Evidence IMP,ISS] [PMID 2146269]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP] [PMID 7866306]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 15254373]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 2146269]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
mitochondrial 54S ribosomal protein RML2
Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9445368]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9445368]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 9079633]; GO_process: GO:0006412 - translation [Evidence IEA]
Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01738
Putative cysteine synthase; localized to the mitochondrial outer membrane; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12867
Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 11842115]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11842115]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071008 - U2-type post-mRNA release spliceosomal complex [Evidence IDA] [PMID 11105756]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11842115]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IDA] [PMID 19617314]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01268
Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 1400574]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 3882418]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2651436]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2689224]
Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 12206772]; GO_component: GO:0005643 - nuclear pore [Evidence IDA,IGI] [PMID 12411502]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11139493]; GO_component: GO:0070390 - transcription export complex 2 [Evidence IDA] [PMID 15311284]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12702719]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 12702719]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 12411502]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0071033 - nuclear retention of pre-mRNA at the site of transcription [Evidence IMP] [PMID 18003937]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 18003937]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11139493]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]; GO_process: GO:0006810 - transport [Evidence IEA]
type 2A-related serine/threonine-protein phosphatase SIT4
similar to AA sequence:KEGG_Orthology:K15427
Type 2A-related serine-threonine phosphatase; functions in the G1/S transition of the mitotic cycle; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 1848673]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IMP] [PMID 23864707]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15150670]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 1848673]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 15367655]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 12080055]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 18357452]; GO_process: GO:0016311 - dephosphorylation [Evidence IMP] [PMID 15367655]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 12080055]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IMP] [PMID 12080055]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15843932]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K03434
ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence ISS] [PMID 10085243]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000225 - N-acetylglucosaminylphosphatidylinositol deacetylase activity [Evidence IEA]; GO_function: GO:0000225 - N-acetylglucosaminylphosphatidylinositol deacetylase activity [Evidence ISS] [PMID 10085243]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence ISS] [PMID 10085243]
similar to AA sequence:KEGG_Orthology:K03235
Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication; GO_component: GO:0022626 - cytosolic ribosome [Evidence IPI] [PMID 9544245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9544245]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IGI,ISS] [PMID 9544245]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA]; GO_process: GO:0006414 - translational elongation [Evidence IGI] [PMID 9544245]
similar to AA sequence:KEGG_Orthology:K17086
Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 8314797]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20681974]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI,IMP] [PMID 20681974]; GO_process: GO:0016197 - endosomal transport [Evidence IMP] [PMID 20526336]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
similar to AA sequence:KEGG_Orthology:K10405
Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 2138512]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000922 - spindle pole [Evidence IDA] [PMID 14562095]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 11729143]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 2138512]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 8106549]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 22734002]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0008569 - minus-end-directed microtubule motor activity [Evidence IDA] [PMID 8041770]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16107877]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 2138512]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IDA,IMP] [PMID 11729143]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IGI] [PMID 9201713]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 16380440]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 2138512]
Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 15769876]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15769876]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15769876]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10375636]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016653 - oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Evidence IGI,IMP] [PMID 11788607]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IGI,IMP] [PMID 11788607]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12970193]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 20534343]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 21944752]
ATP-binding cassette alpha-factor transporter STE6
similar to AA sequence:KEGG_Orthology:K05658
Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8045256]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12374868]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 7679674]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7679674]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 11389139]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 8626301]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000770 - peptide pheromone export [Evidence IMP] [PMID 2569166]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase
similar to AA sequence:KEGG_Orthology:K00550
Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 2445736]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008170 - N-methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0080101 - phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0080101 - phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [Evidence IDA,IGI] [PMID 2445736]; GO_function: GO:0080101 - phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [Evidence IMP] [PMID 2684666]; GO_function: GO:0000773 - phosphatidyl-N-methylethanolamine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0000773 - phosphatidyl-N-methylethanolamine N-methyltransferase activity [Evidence IDA,IGI] [PMID 2445736]; GO_function: GO:0000773 - phosphatidyl-N-methylethanolamine N-methyltransferase activity [Evidence IMP] [PMID 2684666]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 23000174]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA,IGI] [PMID 2445736]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 6337128]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IEA]
Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 7814363]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07561
Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA,IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 15485916]
similar to AA sequence:KEGG_Orthology:K14764
Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12228251]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 19426738]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP,IPI] [PMID 12228251]
aminophospholipid translocase regulatory protein CDC50
Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 12589066]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15090616]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 15090616]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI] [PMID 16195350]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 16195350]; GO_process: GO:0006886 - intracellular protein transport [Evidence IMP] [PMID 16956384]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI] [PMID 15090616]
similar to AA sequence:KEGG_Orthology:K00559
Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11298754]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9450962]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003838 - sterol 24-C-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003838 - sterol 24-C-methyltransferase activity [Evidence IDA] [PMID 18563465]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 2677674]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 6363386]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015183 - L-aspartate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0005313 - L-glutamate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015297 - antiporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015292 - uniporter activity [Evidence IDA] [PMID 14622413]; GO_process: GO:0015813 - L-glutamate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015810 - aspartate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0044271 - cellular nitrogen compound biosynthetic process [Evidence IMP] [PMID 14622413]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01897
Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 8670886]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IDA] [PMID 8206942]; GO_function: GO:0031956 - medium-chain fatty acid-CoA ligase activity [Evidence IDA] [PMID 8206942]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0031957 - very long-chain fatty acid-CoA ligase activity [Evidence IGI] [PMID 9988704]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001676 - long-chain fatty acid metabolic process [Evidence IGI,IMP] [PMID 7962057]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3169249]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 7721780]; GO_function: GO:0031491 - nucleosome binding [Evidence ISS] [PMID 11432837]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IGI] [PMID 11287614]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IDA] [PMID 17178828]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI] [PMID 14739928]; GO_process: GO:0001195 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter [Evidence IDA] [PMID 16407207]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 8946917]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16261
Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K02973
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IGI,IMP] [PMID 8415737]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IGI,IMP] [PMID 8950190]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14793
Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 11105764]; GO_process: GO:0000154 - rRNA modification [Evidence TAS] [PMID 10690410]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16315
similar to AA sequence:KEGG_Orthology:K03115
Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IEA]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IEA]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IMP] [PMID 11827175]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IPI] [PMID 8135547]; GO_function: GO:0030291 - protein serine/threonine kinase inhibitor activity [Evidence IDA] [PMID 18265947]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 16607517]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0045859 - regulation of protein kinase activity [Evidence IEA]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
similar to AA sequence:KEGG_Orthology:K04082
Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11278728]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051087 - chaperone binding [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence IMP] [PMID 11278728]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 9813017]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9813017]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 11278728]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0051259 - protein oligomerization [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
hypothetical protein; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 16582425]
similar to AA sequence:KEGG_Orthology:K01814
DNA-directed RNA polymerase II core subunit RPB3
similar to AA sequence:KEGG_Orthology:K03011
RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15520468]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 16537912]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2685562]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17972
Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; GO_component: GO:0031416 - NatB complex [Evidence IDA] [PMID 12783868]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IMP,ISS] [PMID 10545125]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0017196 - N-terminal peptidyl-methionine acetylation [Evidence IMP] [PMID 10545125]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IGI,IMP] [PMID 12808144]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 12808144]
similar to AA sequence:KEGG_Orthology:K03178
Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7629121]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7629121]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008641 - small protein activating enzyme activity [Evidence IEA]; GO_function: GO:0004839 - ubiquitin activating enzyme activity [Evidence IDA] [PMID 1989885]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 1989885]
polyprotein of L1-like non-LTR retrotransposon Zorro 3
branched-chain-amino-acid transaminase BAT1
similar to AA sequence:KEGG_Orthology:K00826
Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8798704]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0052656 - L-isoleucine transaminase activity [Evidence IEA]; GO_function: GO:0052654 - L-leucine transaminase activity [Evidence IEA]; GO_function: GO:0052655 - L-valine transaminase activity [Evidence IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IDA] [PMID 8798704]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,IMP] [PMID 8798704]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IMP] [PMID 8702755]; GO_process: GO:0009081 - branched-chain amino acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00344
NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0032440 - 2-alkenal reductase [NAD(P)] activity [Evidence IDA] [PMID 21276778]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 17497241]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 19007762]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IEA]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IDA] [PMID 17497241]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17497241]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
similar to several putative epoxide hydrolases; has match to alpha/beta hydrolase fold; allele of CaO19.6709
GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006113 - fermentation [Evidence IMP] [PMID 10781556]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 19433630]
GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 23878277]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 9038344]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI] [PMID 9038344]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IMP] [PMID 10625705]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IGI] [PMID 11713681]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IMP] [PMID 12207708]; GO_process: GO:0032321 - positive regulation of Rho GTPase activity [Evidence IDA] [PMID 9038344]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IGI] [PMID 2183030]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IGI] [PMID 9038344]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 10625705]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI] [PMID 12949174]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12562
Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10393809]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16239147]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 10393809]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI,ISS] [PMID 10388809]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20610658]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20610658]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IPI] [PMID 15802519]
similar to AA sequence:KEGG_Orthology:K14550
Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 17652137]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17652137]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 17652137]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08330
One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 11916983]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8978672]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11916983]; GO_function: GO:0008289 - lipid binding [Evidence IDA,IMP] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0008142 - oxysterol binding [Evidence IMP,IPI] [PMID 16136145]; GO_function: GO:0070300 - phosphatidic acid binding [Evidence IDA] [PMID 20729555]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IMP,IPI] [PMID 11916983]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA] [PMID 20729555]; GO_function: GO:0015248 - sterol transporter activity [Evidence IDA,IMP] [PMID 20008566]; GO_process: GO:0035621 - ER to Golgi ceramide transport [Evidence IMP] [PMID 24213531]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0010922 - positive regulation of phosphatase activity [Evidence IDA] [PMID 21295699]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IGI] [PMID 11916983]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IGI] [PMID 8978672]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]; GO_process: GO:0015918 - sterol transport [Evidence IDA,IGI] [PMID 16585271]; GO_process: GO:0015918 - sterol transport [Evidence IDA,IMP] [PMID 20008566]
similar to AA sequence:KEGG_Orthology:K11874
Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 12914939]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0016579 - protein deubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
potential heme/steroid binding protein; similar to A. thaliana F17I14_130; allele of CaO19.4522
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1
similar to AA sequence:KEGG_Orthology:K01956
Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader; GO_component: GO:0005951 - carbamoyl-phosphate synthase complex [Evidence IDA] [PMID 206535]; GO_component: GO:0005951 - carbamoyl-phosphate synthase complex [Evidence ISS] [PMID 6086650]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IMP] [PMID 6086650]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 8626695]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 9290206]; GO_process: GO:0070409 - carbamoyl phosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006543 - glutamine catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05545
Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence ISS] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence ISS] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17907
similar to AA sequence:KEGG_Orthology:K14766
Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030692 - Noc4p-Nop14p complex [Evidence IPI] [PMID 12446671]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11694595]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 11694595]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13535
Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23637464]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19244244]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004623 - phospholipase A2 activity [Evidence IDA,IMP] [PMID 19244244]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 19244244]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 23637464]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IDA,IGI] [PMID 19244244]
similar to AA sequence:KEGG_Orthology:K16066
NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 18630881]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_function: GO:0031132 - serine 3-dehydrogenase activity [Evidence IDA] [PMID 12535615]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IC] [PMID 12535615]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00450
hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00480
similar to AA sequence:KEGG_Orthology:K00101
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 3004948]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 3004948]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 11566870]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0000295 - adenine nucleotide transmembrane transporter activity [Evidence IMP] [PMID 11390660]; GO_function: GO:0000295 - adenine nucleotide transmembrane transporter activity [Evidence IDA] [PMID 11566870]; GO_process: GO:0015867 - ATP transport [Evidence IDA] [PMID 11566870]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IGI,IMP] [PMID 11390660]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IGI,IMP] [PMID 11566870]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IMP] [PMID 11390660]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01637
Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IEA,IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IMP,ISS] [PMID 1551398]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence TAS] [PMID 11092862]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17724
similar to AA sequence:KEGG_Orthology:K06659
High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13511
Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16135531]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 16880272]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16880272]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15304507]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15588229]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IEA]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IMP] [PMID 15588229]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 14651618]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IMP] [PMID 14651618]; GO_process: GO:0007007 - inner mitochondrial membrane organization [Evidence IMP] [PMID 14651618]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042775 - mitochondrial ATP synthesis coupled electron transport [Evidence IMP] [PMID 15304507]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 14651618]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 15588229]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 16135531]
Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IDA,IPI] [PMID 9154821]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0070461 - SAGA-type complex [Evidence IEA]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IMP] [PMID 10048020]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IMP,IPI] [PMID 9154821]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9154821]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Pentatricopeptide repeat-containing protein At1g63130, mitochondrial
Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 10446242]; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 10487921]; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 7565763]; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 8413209]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 10446242]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 7565763]; GO_function: GO:0001078 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Evidence IMP] [PMID 10446242]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IMP] [PMID 14665463]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 10446242]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 10487921]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 8413209]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10446242]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10487921]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 16835445]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2546055]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2847035]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3062365]; GO_process: GO:0097201 - negative regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 21299653]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08493
Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 9398683]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 19805279]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9199167]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 9398683]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 10385523]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11739407]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17764
similar to AA sequence:KEGG_Orthology:K14786
Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 22180534]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11027267]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11027267]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11400
Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10436015]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10911987]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10436015]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 10911987]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 16088870]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 10911987]; GO_function: GO:0031493 - nucleosomal histone binding [Evidence IDA] [PMID 10911987]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 12353039]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15610740]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence IMP,IPI] [PMID 10436015]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0051382 - kinetochore assembly [Evidence IMP] [PMID 17452364]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 10911987]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 8598290]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17785
Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21944719]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21987634]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 22009199]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 19528297]; GO_component: GO:0044284 - mitochondrial crista junction [Evidence IDA] [PMID 22009199]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 19528297]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 19528297]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21944719]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21987634]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 22009199]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP,IPI] [PMID 21944719]
similar to AA sequence:KEGG_Orthology:K03514
Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia; PAP2 has a paralog, TRF5, that arose from the whole genome duplication; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935758]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935759]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16541108]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10066793]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0051575 - 5'-deoxyribose-5-phosphate lyase activity [Evidence IDA,IMP] [PMID 17983848]; GO_function: GO:0034459 - ATP-dependent 3'-5' RNA helicase activity [Evidence IDA] [PMID 22532666]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 12062100]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IMP,ISS] [PMID 15828860]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 15935758]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IMP] [PMID 15935759]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IMP] [PMID 16260630]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IGI] [PMID 16374505]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 16373491]; GO_process: GO:0006284 - base-excision repair [Evidence IGI,IMP] [PMID 17983848]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0071044 - histone mRNA catabolic process [Evidence IGI] [PMID 17179095]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 15145828]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA,IMP] [PMID 15828860]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15935758]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 15935759]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 16373491]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 16374505]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IMP] [PMID 16431988]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IMP] [PMID 23762389]; GO_process: GO:0071031 - nuclear mRNA surveillance of mRNA 3'-end processing [Evidence IGI] [PMID 17410208]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IGI,IMP] [PMID 15935759]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 16973436]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18007593]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18591258]; GO_process: GO:0071040 - nuclear polyadenylation-dependent antisense transcript catabolic process [Evidence IMP] [PMID 18022365]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IGI] [PMID 16373491]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI,IMP] [PMID 15935758]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI] [PMID 16541108]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18007593]; GO_process: GO:0071037 - nuclear polyadenylation-dependent snRNA catabolic process [Evidence IMP] [PMID 15935758]; GO_process: GO:0071037 - nuclear polyadenylation-dependent snRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071036 - nuclear polyadenylation-dependent snoRNA catabolic process [Evidence IGI,IMP] [PMID 15935758]; GO_process: GO:0071036 - nuclear polyadenylation-dependent snoRNA catabolic process [Evidence IGI] [PMID 16373491]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IGI] [PMID 15145828]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IMP] [PMID 18456844]; GO_process: GO:0071047 - polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IGI] [PMID 16373491]; GO_process: GO:0071050 - snoRNA polyadenylation [Evidence IGI] [PMID 18951092]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 22319136]
similar to AA sequence:KEGG_Orthology:K07889
Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IMP] [PMID 11872141]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 8163546]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 22748138]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 23612966]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8163546]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 22748138]; GO_process: GO:0036258 - multivesicular body assembly [Evidence IGI] [PMID 22748138]; GO_process: GO:0036010 - protein localization to endosome [Evidence IGI] [PMID 23264632]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8163546]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]
similar to AA sequence:KEGG_Orthology:K16219
AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 20481588]; GO_function: GO:0071885 - N-terminal protein N-methyltransferase activity [Evidence IDA,IMP] [PMID 20481588]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0018016 - N-terminal peptidyl-proline dimethylation [Evidence IDA,IMP] [PMID 20481588]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IMP] [PMID 19055778]; GO_process: GO:0032259 - methylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10956
Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 8612571]; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 9252322]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IMP] [PMID 1550957]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IDA] [PMID 9252322]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 10758167]; GO_function: GO:0005048 - signal sequence binding [Evidence IDA] [PMID 12134063]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 19696741]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 24314051]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 11076036]; GO_process: GO:0044743 - intracellular protein transmembrane import [Evidence IMP] [PMID 24314051]; GO_process: GO:0070843 - misfolded protein transport [Evidence IMP] [PMID 24314051]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 7758110]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 9252322]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 9843581]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 10635318]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 9303298]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14805
Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 13680366]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 7754712]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 13680366]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 13680366]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 13680366]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 7739558]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03265
Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23451152]; GO_component: GO:0005829 - cytosol [Evidence IPI] [PMID 1474892]; GO_component: GO:0018444 - translation release factor complex [Evidence IDA] [PMID 7556078]; GO_function: GO:0003747 - translation release factor activity [Evidence IDA] [PMID 20947765]; GO_function: GO:0016149 - translation release factor activity, codon specific [Evidence IEA]; GO_function: GO:0016149 - translation release factor activity, codon specific [Evidence IMP,ISS] [PMID 9182990]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IGI,IMP] [PMID 18724935]; GO_process: GO:0006415 - translational termination [Evidence IDA] [PMID 20947765]; GO_process: GO:0006415 - translational termination [Evidence IMP,ISS] [PMID 9182990]
similar to AA sequence:KEGG_Orthology:K06013
Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11581258]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IMP] [PMID 18923140]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 11581258]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP,ISS] [PMID 9065405]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0071586 - CAAX-box protein processing [Evidence IMP] [PMID 9065405]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IDA] [PMID 11581258]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IMP] [PMID 9065405]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]
High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 8893857]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000102 - L-methionine secondary active transmembrane transporter activity [Evidence IDA] [PMID 8893857]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0042883 - cysteine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0044690 - methionine import [Evidence IGI,IMP] [PMID 8893857]; GO_process: GO:0015821 - methionine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0000101 - sulfur amino acid transport [Evidence IMP] [PMID 8893857]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01078
Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 11024051]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006342 - chromatin silencing [Evidence IGI,IMP] [PMID 11024051]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP,IPI] [PMID 11024051]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16314178]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19372273]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17210643]; GO_process: GO:0061408 - positive regulation of transcription from RNA polymerase II promoter in response to heat stress [Evidence IMP] [PMID 20398213]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03854
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 9090056]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 9090056]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IC] [PMID 9090056]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
stress-regulated transcription factor RPN4
TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3
similar to AA sequence:KEGG_Orthology:K10844
5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 2827162]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 8132553]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0033683 - nucleotide-excision repair, DNA incision [Evidence IDA] [PMID 8631896]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0045951 - positive regulation of mitotic recombination [Evidence IMP] [PMID 24189665]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 10713167]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 9799251]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0010525 - regulation of transposition, RNA-mediated [Evidence IMP] [PMID 10713167]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01426
Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03952
similar to AA sequence:KEGG_Orthology:K11274
Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11695919]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0046547 - trans-aconitate 3-methyltransferase activity [Evidence IEA]; GO_function: GO:0046547 - trans-aconitate 3-methyltransferase activity [Evidence IDA] [PMID 11695919]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11121
Cytoplasmic NAD(+)-dependent protein deacetylase; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11226170]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17110954]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0070403 - NAD+ binding [Evidence IEA]; GO_function: GO:0017136 - NAD-dependent histone deacetylase activity [Evidence IDA] [PMID 10811920]; GO_function: GO:0017136 - NAD-dependent histone deacetylase activity [Evidence IMP] [PMID 10841563]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 11226170]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 16051752]; GO_process: GO:0001300 - chronological cell aging [Evidence IGI,IMP] [PMID 16051752]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 11226170]; GO_process: GO:0045950 - negative regulation of mitotic recombination [Evidence IGI,IMP] [PMID 16051752]; GO_process: GO:0006476 - protein deacetylation [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation involved in protein translation; monitors translation stress and signals this to Hsf1p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23222640]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IMP] [PMID 20691087]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 23479637]; GO_process: GO:0006412 - translation [Evidence IEA]
Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; GO_component: GO:0030126 - COPI vesicle coat [Evidence IMP,ISS] [PMID 8617224]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8617224]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14650
TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 17660549]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11447600]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23613772]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11447600]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11447600]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 15514049]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 23613772]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 15514049]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000755 - cytogamy [Evidence IGI,IMP] [PMID 15514049]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI] [PMID 11447600]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0032321 - positive regulation of Rho GTPase activity [Evidence IDA] [PMID 15514049]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IGI] [PMID 11447600]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI] [PMID 11447600]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11382760]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11382760]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 11689437]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 11382761]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11382761]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 23382696]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0030242 - peroxisome degradation [Evidence IDA,IEP,IMP] [PMID 11382760]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17906
General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 12499351]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15039776]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 15039776]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 9199164]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IMP] [PMID 14523026]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15707981]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 6759873]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 15707981]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 6759873]; GO_process: GO:0015846 - polyamine transport [Evidence IMP] [PMID 15707981]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15627
Mitochondrial hypothetical protein; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
ATP-binding cassette glutathione S-conjugate transporter YCF1
Vacuolar glutathione S-conjugate transporter; member of ATP-binding cassette family; ATPase activity required to support vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; has role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23658021]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8692889]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015127 - bilirubin transmembrane transporter activity [Evidence IGI,IMP] [PMID 10790694]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 10220408]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12383937]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12755704]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 9217966]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015723 - bilirubin transport [Evidence IGI,IMP] [PMID 10790694]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 10220408]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 12755704]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 9217966]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10790694]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 23658021]
similar to AA sequence:KEGG_Orthology:K18551
Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008252 - nucleotidase activity [Evidence IDA] [PMID 11934891]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006206 - pyrimidine nucleobase metabolic process [Evidence IMP] [PMID 11934891]
similar to AA sequence:KEGG_Orthology:K00030
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated; GO_component: GO:0005962 - mitochondrial isocitrate dehydrogenase complex (NAD+) [Evidence IDA] [PMID 16884682]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 16884682]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IDA] [PMID 16884682]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog, HEH2, that arose from the whole genome duplication; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IDA] [PMID 18762579]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005639 - integral component of nuclear inner membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 16929305]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043007 - maintenance of rDNA [Evidence IMP] [PMID 18997772]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 11754482]
similar to AA sequence:KEGG_Orthology:K01490
AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003876 - AMP deaminase activity [Evidence IEA,IEA]; GO_function: GO:0003876 - AMP deaminase activity [Evidence IDA,IMP] [PMID 2690949]; GO_function: GO:0019239 - deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006188 - IMP biosynthetic process [Evidence IEA]; GO_process: GO:0032264 - IMP salvage [Evidence IEA]; GO_process: GO:0006178 - guanine salvage [Evidence IGI,IMP] [PMID 19635936]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IGI] [PMID 15869715]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IGI] [PMID 18433446]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IGI,IMP] [PMID 19635936]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IMP] [PMID 20087341]; GO_process: GO:0009168 - purine ribonucleoside monophosphate biosynthetic process [Evidence IEA]
Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19194512]; GO_function: GO:0010181 - FMN binding [Evidence IEA,IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0003958 - NADPH-hemoprotein reductase activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016651 - oxidoreductase activity, acting on NAD(P)H [Evidence IEA]; GO_function: GO:0016651 - oxidoreductase activity, acting on NAD(P)H [Evidence IDA] [PMID 20802492]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 20802492]; GO_process: GO:0006809 - nitric oxide biosynthetic process [Evidence IMP] [PMID 23159617]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IDA] [PMID 20802492]
similar to AA sequence:KEGG_Orthology:K03687
N-terminus has a leader sequence with features reminiscent of mitochondrial import signals. Translated as a 28KDa precursor protein which is cleaved to a 21KDa mature form.
similar to AA sequence:KEGG_Orthology:K01889
Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3029120]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 16162501]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 1924298]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IMP,ISS] [PMID 3029120]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0070156 - mitochondrial phenylalanyl-tRNA aminoacylation [Evidence IMP] [PMID 3029120]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 1924298]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
mitochondrial 54S ribosomal protein YmL47
Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetically lethal with hac1 mutant suggesting a role in the maturation of secretory proteins; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 7478995]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 7478995]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7478995]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 19433630]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10756
Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA] [PMID 7651383]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IMP] [PMID 8559655]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12909721]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12912927]; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IPI] [PMID 11389843]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IMP] [PMID 12665596]
glucose-inactivated glycerol proton symporter STL1
similar to AA sequence:KEGG_Orthology:K13237
Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01808
similar to AA sequence:KEGG_Orthology:K00863
Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IDA] [PMID 12401799]; GO_function: GO:0004371 - glycerone kinase activity [Evidence ISS] [PMID 9038161]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0050354 - triokinase activity [Evidence IEA]; GO_process: GO:0019588 - anaerobic glycerol catabolic process [Evidence IEA]; GO_process: GO:0097237 - cellular response to toxic substance [Evidence IMP] [PMID 12401799]; GO_process: GO:0019563 - glycerol catabolic process [Evidence ISS] [PMID 9038161]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01803
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IDA] [PMID 236471]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 11329176]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17550
Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11801737]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000164 - protein phosphatase type 1 complex [Evidence IDA] [PMID 10775415]; GO_function: GO:0071862 - protein phosphatase type 1 activator activity [Evidence IGI] [PMID 11801737]; GO_function: GO:0071862 - protein phosphatase type 1 activator activity [Evidence IGI] [PMID 18172024]; GO_function: GO:0004865 - protein serine/threonine phosphatase inhibitor activity [Evidence IGI,IMP] [PMID 17142459]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 11801737]; GO_process: GO:0051457 - maintenance of protein location in nucleus [Evidence IMP] [PMID 11801737]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03955
Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0000036 - ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process [Evidence ISS] [PMID 8394042]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009107 - lipoate biosynthetic process [Evidence IMP] [PMID 9187370]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
putative mitogen-activated protein kinase kinase MKK2
similar to AA sequence:KEGG_Orthology:K08294
similar to AA sequence:KEGG_Orthology:K06694
Assembly chaperone for the 19S proteasome regulatory particle base; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0005838 - proteasome regulatory particle [Evidence IDA] [PMID 11029046]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19412159]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]; GO_process: GO:0006508 - proteolysis [Evidence IPI,ISS] [PMID 11029046]
similar to AA sequence:KEGG_Orthology:K02883
Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10206705]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10206705]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042546 - cell wall biogenesis [Evidence IEA]; GO_process: GO:0032995 - regulation of fungal-type cell wall biogenesis [Evidence IGI,IMP] [PMID 10206705]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IGI] [PMID 11410349]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 12823808]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02958
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 15167894]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
hypothetical protein; mtc6 is synthetically sick with cdc13-1; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K17081
Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR); GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10835343]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9632789]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9259555]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP] [PMID 12882345]; GO_process: GO:0045861 - negative regulation of proteolysis [Evidence IMP,IPI] [PMID 10207067]; GO_process: GO:0006457 - protein folding [Evidence IDA,IPI,ISS] [PMID 10835343]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12882345]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 9259555]
similar to AA sequence:KEGG_Orthology:K00814
Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004021 - L-alanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0004021 - L-alanine:2-oxoglutarate aminotransferase activity [Evidence IMP] [PMID 19396236]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042853 - L-alanine catabolic process [Evidence IEA]; GO_process: GO:0006523 - alanine biosynthetic process [Evidence IMP] [PMID 19396236]; GO_process: GO:0006524 - alanine catabolic process [Evidence IMP] [PMID 19396236]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 23527786]
Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12052876]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IPI] [PMID 12052876]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 12052876]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 23530227]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 12052876]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03457
Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 1293888]; GO_function: GO:0005274 - allantoin uptake transmembrane transporter activity [Evidence ISS] [PMID 1293888]; GO_function: GO:0005274 - allantoin uptake transmembrane transporter activity [Evidence IMP] [PMID 385448]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IMP] [PMID 385448]; GO_process: GO:0015720 - allantoin transport [Evidence IMP] [PMID 3549700]; GO_process: GO:0015720 - allantoin transport [Evidence IMP] [PMID 385448]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 20581295]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IPI] [PMID 10906145]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 17603098]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10906145]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7899074]; GO_process: GO:1901717 - positive regulation of gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:1901714 - positive regulation of urea catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15428
Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17179087]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0016805 - dipeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070573 - metallodipeptidase activity [Evidence IDA,IMP] [PMID 19346245]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008242 - omega peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0034701 - tripeptidase activity [Evidence IEA]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 17179087]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03259
mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8119957]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence TAS] [PMID 9841679]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8119957]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 3062383]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA,IPI] [PMID 15753296]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 2540596]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence ISS] [PMID 3062383]
DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 8889513]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA,IPI,ISS] [PMID 8889513]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009063 - cellular amino acid catabolic process [Evidence IGI,IMP] [PMID 8889513]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IMP] [PMID 8889513]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00888
Phosphatidylinositol-4-kinase; functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12015967]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19075114]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IMP] [PMID 8288577]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 9346907]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IGI] [PMID 10930462]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9346907]; GO_process: GO:0048015 - phosphatidylinositol-mediated signaling [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09202
similar to AA sequence:KEGG_Orthology:K00658
Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045252 - oxoglutarate dehydrogenase complex [Evidence IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence ISA] [PMID 2115121]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence IMP] [PMID 2115121]; GO_process: GO:0033512 - L-lysine catabolic process to acetyl-CoA via saccharopine [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 10869431]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IC] [PMID 2072900]
bifunctional choline kinase/ethanolamine kinase CKI1
similar to AA sequence:KEGG_Orthology:K00866
Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004103 - choline kinase activity [Evidence IEA]; GO_function: GO:0004103 - choline kinase activity [Evidence IGI,IMP] [PMID 10329685]; GO_function: GO:0004103 - choline kinase activity [Evidence IDA] [PMID 2536698]; GO_function: GO:0004305 - ethanolamine kinase activity [Evidence IGI,IMP] [PMID 10329685]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006657 - CDP-choline pathway [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
Putative RNA-binding protein; required for the expression of early and middle sporulation genes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP,ISS] [PMID 10806425]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEP] [PMID 10806425]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 11713679]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IMP] [PMID 11713679]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 11713679]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IGI,IMP] [PMID 10806425]
similar to AA sequence:KEGG_Orthology:K08337
Autophagy-related protein and dual specificity member of the E1 family; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10233150]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 10233148]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_function: GO:0019778 - Atg12 activating enzyme activity [Evidence IMP] [PMID 10233150]; GO_function: GO:0019779 - Atg8 activating enzyme [Evidence IMP] [PMID 11100732]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11038174]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11100732]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 12965207]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IDA,IMP] [PMID 15277523]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 10233150]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12965207]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 23382696]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 10233150]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 12965207]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0032446 - protein modification by small protein conjugation [Evidence IMP] [PMID 10233150]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03106
Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0048500 - signal recognition particle [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 7925282]; GO_function: GO:0008312 - 7S RNA binding [Evidence IEA]; GO_function: GO:0008312 - 7S RNA binding [Evidence IDA] [PMID 14681587]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 2187859]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IPI] [PMID 7925282]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IMP] [PMID 1655273]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence ISA] [PMID 2187859]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IC] [PMID 7925282]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IPI] [PMID 7925282]
similar to AA sequence:KEGG_Orthology:K01733
Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004795 - threonine synthase activity [Evidence IEA]; GO_function: GO:0004795 - threonine synthase activity [Evidence IMP] [PMID 8082795]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 8082795]
similar to AA sequence:KEGG_Orthology:K14403
Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 10523662]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IC] [PMID 9099738]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IMP,ISS] [PMID 15037765]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IMP] [PMID 18971324]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 18971324]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 18971324]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 18971324]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 18971324]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 18971324]
Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17157937]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 17157937]
similar to AA sequence:KEGG_Orthology:K15458
Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 8649382]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI,IMP,IPI] [PMID 8649382]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 15367655]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IMP] [PMID 15367655]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IGI] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K07513
3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 7754706]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA,IMP,ISM] [PMID 8125978]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 19470242]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IEA]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IDA] [PMID 7754706]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
glucose-induced degradation complex subunit VID30
Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IMP] [PMID 11356843]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 8844145]
similar to AA sequence:KEGG_Orthology:K17498
Protein involved in RNA polymerase II transcription; is constitutively recruited to the CYC1 promoter and is required for recruitment of chromatin remodeling factors for the expression of CYC1 gene; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12524336]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12556496]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 18086892]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 21094070]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 21156811]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 12556496]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IPI] [PMID 12556496]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IPI] [PMID 18086892]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 19034519]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IPI] [PMID 21094070]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 21156811]; GO_process: GO:0034243 - regulation of transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 18086892]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 12524336]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI,IPI] [PMID 12556496]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11675
Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 12887900]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 12887900]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01341
similar to AA sequence:KEGG_Orthology:K02646
Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1493793]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 2664469]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 3303332]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IGI,IMP] [PMID 7902583]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IGI,IMP] [PMID 9566882]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 2196175]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IGI,IMP] [PMID 3303332]; GO_process: GO:0043388 - positive regulation of DNA binding [Evidence IMP] [PMID 7902583]; GO_process: GO:0043388 - positive regulation of DNA binding [Evidence IDA] [PMID 8355698]; GO_process: GO:0045937 - positive regulation of phosphate metabolic process [Evidence IGI] [PMID 3915785]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 3303332]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 3915785]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 7902583]; GO_process: GO:2000679 - positive regulation of transcription regulatory region DNA binding [Evidence IMP] [PMID 9354395]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IDA,IMP] [PMID 1495962]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
hypothetical protein; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031901 - early endosome membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K02937
Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19466602]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23874617]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19466602]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 23874617]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 23874617]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 22893726]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 23945946]
similar to AA sequence:KEGG_Orthology:K09175
Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9741624]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 16835445]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9741624]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16107689]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]
Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 17272295]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11489916]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17804645]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17272295]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17804645]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 17272295]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 9171383]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 19380492]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0051457 - maintenance of protein location in nucleus [Evidence IPI] [PMID 19380492]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI] [PMID 9106207]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI,IMP] [PMID 9171427]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
NADH-ubiquinone reductase (H(+)-translocating) NDE1
similar to AA sequence:KEGG_Orthology:K03885
Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9696750]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9733747]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9696750]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9733747]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 16436509]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9696750]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9733747]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12388763]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 19158382]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 19158382]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 12388763]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IDA] [PMID 19158382]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 10512884]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 12388763]
similar to AA sequence:KEGG_Orthology:K06911
top hit is XP_006261139.1 originated in Alligator mississippiensis
similar to AA sequence:KEGG_Orthology:K14537
Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11707418]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 11707418]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence TAS] [PMID 12362983]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11583615]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP,IPI] [PMID 11707418]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12807768]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,ISS] [PMID 10559187]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 15574876]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12184
Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p; GO_component: GO:0000813 - ESCRT I complex [Evidence IPI] [PMID 11511343]; GO_component: GO:0000813 - ESCRT I complex [Evidence IDA] [PMID 15044434]; GO_component: GO:0000813 - ESCRT I complex [Evidence IPI] [PMID 16615894]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 11511343]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0032403 - protein complex binding [Evidence IDA,IPI] [PMID 17215868]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
similar to AA sequence:KEGG_Orthology:K00232
Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11967269]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA,IEA]; GO_function: GO:0003995 - acyl-CoA dehydrogenase activity [Evidence IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence ISA] [PMID 2189786]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence IEA]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence ISA] [PMID 2189786]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00249
similar to AA sequence:KEGG_Orthology:K05543
Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IDA] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IGI] [PMID 12559567]
similar to AA sequence:KEGG_Orthology:K00854
Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004856 - xylulokinase activity [Evidence IEA]; GO_function: GO:0004856 - xylulokinase activity [Evidence IMP,ISS] [PMID 9595677]; GO_process: GO:0042732 - D-xylose metabolic process [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0005998 - xylulose catabolic process [Evidence IDA] [PMID 10981687]
similar to AA sequence:KEGG_Orthology:K12946
Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 1846444]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 8910564]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IGI,IPI] [PMID 8663399]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IGI,IMP,ISS] [PMID 8663399]
similar to AA sequence:KEGG_Orthology:K08869
Mitochondrial hypothetical protein involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0055088 - lipid homeostasis [Evidence IGI] [PMID 23781023]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IGI,IMP] [PMID 23781023]
similar to AA sequence:KEGG_Orthology:K18477
Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17448464]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17448464]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016274 - protein-arginine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0019702 - protein-arginine N5-methyltransferase activity [Evidence IDA] [PMID 11856739]; GO_function: GO:0019702 - protein-arginine N5-methyltransferase activity [Evidence IMP] [PMID 9873020]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0035246 - peptidyl-arginine N-methylation [Evidence IEA]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IDA] [PMID 11856739]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 9873020]
similar to AA sequence:KEGG_Orthology:K05917
Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15951236]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IDA] [PMID 9087488]; GO_process: GO:0070988 - demethylation [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16073
Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19720860]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence ISS] [PMID 9430719]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0010961 - cellular magnesium ion homeostasis [Evidence IMP] [PMID 19720860]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15732
Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11003641]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,IMP] [PMID 10445027]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 11904169]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA,IMP] [PMID 10445027]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11904169]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 16301539]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 10445027]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 12370301]
similar to AA sequence:KEGG_Orthology:K01835
similar to AA sequence:KEGG_Orthology:K05533
Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 9434768]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 12235155]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA,IMP] [PMID 9430634]; GO_process: GO:0040008 - regulation of growth [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09584
Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IGI,IMP,ISS] [PMID 11157982]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IGI,ISS] [PMID 11157982]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0019153 - protein-disulfide reductase (glutathione) activity [Evidence IDA] [PMID 16002399]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 11157982]
similar to AA sequence:KEGG_Orthology:K14795
Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 20038530]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 20038530]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000469 - cleavage involved in rRNA processing [Evidence IMP] [PMID 20038530]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20038530]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IDA] [PMID 19864628]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA] [PMID 12743123]
Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes; GO_component: GO:0000417 - HIR complex [Evidence IDA,IPI] [PMID 16264190]; GO_component: GO:0000417 - HIR complex [Evidence IDA] [PMID 16303565]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12524332]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16264190]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 1406694]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 16449659]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 7568152]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 9106207]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 19380492]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IGI] [PMID 7568152]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 8622686]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 15215105]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IMP] [PMID 23106982]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 15215105]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 15649438]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0060003 - copper ion export [Evidence IMP] [PMID 23106982]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 15215105]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 15649438]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0010107 - potassium ion import [Evidence IGI,IMP] [PMID 17189489]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00493
N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8183942]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8183942]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08712
Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence TAS] [PMID 10581358]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence TAS] [PMID 11421285]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
ATP-binding cassette multidrug transporter PDR12
Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9687494]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IDA] [PMID 10419965]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0015849 - organic acid transport [Evidence IDA] [PMID 10419965]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K08874
similar to AA sequence:KEGG_Orthology:K11839
Ubiquitin hydrolase that deubiquitinates ILV cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17145966]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 10069815]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 19410548]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 8247125]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9119204]; GO_process: GO:0010995 - free ubiquitin chain depolymerization [Evidence IDA] [PMID 19410548]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IGI] [PMID 23444383]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IMP] [PMID 8657109]; GO_process: GO:0010992 - ubiquitin homeostasis [Evidence IMP] [PMID 19410548]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17145966]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 17376168]
similar to AA sequence:KEGG_Orthology:K00654
Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0017059 - serine C-palmitoyltransferase complex [Evidence IMP] [PMID 1556076]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IMP] [PMID 1556076]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IGI] [PMID 8058731]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 1556076]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14679
tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 3312232]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 20844078]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IDA] [PMID 6297798]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0051730 - GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [Evidence IDA] [PMID 8428918]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3277966]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3512545]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 8898194]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0032056 - positive regulation of translation in response to stress [Evidence IMP,IPI] [PMID 20844078]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IMP] [PMID 1537841]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IDA] [PMID 2207062]
similar to AA sequence:KEGG_Orthology:K00611
Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0016743 - carboxyl- or carbamoyltransferase activity [Evidence IEA]; GO_function: GO:0004585 - ornithine carbamoyltransferase activity [Evidence IEA]; GO_function: GO:0004585 - ornithine carbamoyltransferase activity [Evidence IDA] [PMID 7029528]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 2897249]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006591 - ornithine metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14709
High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 8637895]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000006 - high affinity zinc uptake transmembrane transporter activity [Evidence IMP,ISS] [PMID 8637895]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006830 - high-affinity zinc ion transport [Evidence IMP] [PMID 8637895]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0071577 - zinc ion transmembrane transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18599
activating signal cointegrator 1 complex subunit 3
similar to AA sequence:KEGG_Orthology:K18664
Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0042788 - polysomal ribosome [Evidence IDA] [PMID 21076151]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 9133744]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IGI,IMP] [PMID 10922069]; GO_process: GO:0006417 - regulation of translation [Evidence IGI,IMP] [PMID 11438647]
EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18298591]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IGI] [PMID 18298591]; GO_process: GO:0006914 - autophagy [Evidence IGI] [PMID 18298591]; GO_process: GO:0009267 - cellular response to starvation [Evidence IGI] [PMID 18298591]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 10082585]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 15265867]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IGI] [PMID 15265867]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14770
similar to AA sequence:KEGG_Orthology:K01611
S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004014 - adenosylmethionine decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004014 - adenosylmethionine decarboxylase activity [Evidence IDA] [PMID 2266128]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0006557 - S-adenosylmethioninamine biosynthetic process [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IMP] [PMID 7929015]; GO_process: GO:0006597 - spermine biosynthetic process [Evidence IEA]; GO_process: GO:0006597 - spermine biosynthetic process [Evidence IMP] [PMID 7929015]
RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins; component of ribosome-bound RQC (ribosome quality control) complex required for degradation of polypeptides arising from stalled translation; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17283062]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 20835226]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 20835226]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 17283062]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IGI] [PMID 17283062]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17283062]; GO_process: GO:0010498 - proteasomal protein catabolic process [Evidence IGI,IMP] [PMID 24261871]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 17283062]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 20835226]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23479637]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20835226]
mitochondrial 37S ribosomal protein MRPS28
similar to AA sequence:KEGG_Orthology:K02956
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9445368]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00641
L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0004414 - homoserine O-acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004414 - homoserine O-acetyltransferase activity [Evidence IDA,IMP] [PMID 3301801]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009092 - homoserine metabolic process [Evidence IDA,IMP] [PMID 3301801]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 6035500]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
similar to AA sequence:KEGG_Orthology:K03495
Mitochondrial protein; forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9774408]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070899 - mitochondrial tRNA wobble uridine modification [Evidence IMP] [PMID 15509579]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA]
ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005471 - ATP:ADP antiporter activity [Evidence IMP] [PMID 18485069]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 15238515]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0015866 - ADP transport [Evidence IMP] [PMID 18485069]; GO_process: GO:0015867 - ATP transport [Evidence IMP] [PMID 18485069]; GO_process: GO:0006839 - mitochondrial transport [Evidence IMP] [PMID 18485069]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 21306442]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0070290 - N-acylphosphatidylethanolamine-specific phospholipase D activity [Evidence IEA]; GO_function: GO:0070290 - N-acylphosphatidylethanolamine-specific phospholipase D activity [Evidence ISS] [PMID 15878693]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0070291 - N-acylethanolamine metabolic process [Evidence IMP] [PMID 15878693]; GO_process: GO:0070292 - N-acylphosphatidylethanolamine metabolic process [Evidence IMP] [PMID 15878693]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
3-methyl-2-oxobutanoate hydroxymethyltransferase
similar to AA sequence:KEGG_Orthology:K00606
Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003864 - 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003864 - 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [Evidence IMP,ISS] [PMID 11154694]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]
similar to AA sequence:KEGG_Orthology:K07019
similar to AA sequence:KEGG_Orthology:K13728
Accessory subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev3p, Pol31p and Pol32p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16452144]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16546083]; GO_component: GO:0016035 - zeta DNA polymerase complex [Evidence IDA] [PMID 8658138]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 8658138]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 12514101]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 11313481]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 3897795]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 9765213]
similar to AA sequence:KEGG_Orthology:K19245
glutamyl-tRNA(Gln) amidotransferase subunit HER2
similar to AA sequence:KEGG_Orthology:K02433
Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IEA]; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IDA] [PMID 19417106]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19417106]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA,IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 19417106]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI] [PMID 18667535]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IEA]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IDA] [PMID 19417106]; GO_process: GO:0032543 - mitochondrial translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0042406 - extrinsic component of endoplasmic reticulum membrane [Evidence IDA] [PMID 19416104]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19416104]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18493054]; GO_function: GO:0003682 - chromatin binding [Evidence IDA,IMP] [PMID 19581291]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 16079223]; GO_function: GO:0042393 - histone binding [Evidence IDA,IMP] [PMID 19581291]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 15824130]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 16079223]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 19581291]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18493054]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 19683497]
Signal recognition particle receptor subunit alpha
similar to AA sequence:KEGG_Orthology:K13431
Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9679135]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005785 - signal recognition particle receptor complex [Evidence IPI] [PMID 9679135]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IPI] [PMID 7844142]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005047 - signal recognition particle binding [Evidence IMP,ISS] [PMID 1327299]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IC,TAS] [PMID 7844142]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1327299]; GO_process: GO:0006810 - transport [Evidence IEA]
Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 11935221]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0032934 - sterol binding [Evidence IDA] [PMID 23027975]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0015918 - sterol transport [Evidence IGI,IMP] [PMID 23027975]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07874
Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates unfolded protein response (UPR) by promoting the decay of HAC1 RNA; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0005795 - Golgi stack [Evidence IDA] [PMID 12802060]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IDA] [PMID 23129774]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 20375281]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 20059749]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 3311726]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 9447979]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 18388317]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 15689495]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20375281]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 15689495]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 2504726]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7593181]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IGI] [PMID 18388317]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IMP] [PMID 9545229]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IMP] [PMID 9157884]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 20059749]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 20059749]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20375281]; GO_process: GO:1990261 - pre-mRNA catabolic process [Evidence IMP] [PMID 22844259]; GO_process: GO:0006461 - protein complex assembly [Evidence IDA] [PMID 8603910]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22844259]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IGI,IMP] [PMID 18388317]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
guanine nucleotide-binding protein subunit alpha
similar to AA sequence:KEGG_Orthology:K04640
Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16839886]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IBA]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA,IPI] [PMID 11394869]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8756677]; GO_function: GO:0031683 - G-protein beta/gamma-subunit complex binding [Evidence IBA,IEA]; GO_function: GO:0001664 - G-protein coupled receptor binding [Evidence IBA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11394869]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 1900495]; GO_function: GO:0019001 - guanyl nucleotide binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IBA,IEA,IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 12556475]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 2105453]; GO_process: GO:0007189 - adenylate cyclase-activating G-protein coupled receptor signaling pathway [Evidence IBA,IEA]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IMP] [PMID 16839886]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 3113739]; GO_process: GO:0071701 - regulation of MAPK export from nucleus [Evidence IMP] [PMID 12556475]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA,IEA]
Arf family guanine nucleotide exchange factor SEC7
similar to AA sequence:KEGG_Orthology:K18442
similar to AA sequence:KEGG_Orthology:K05389
Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 7651518]; GO_function: GO:0005267 - potassium channel activity [Evidence IEA]; GO_function: GO:0005267 - potassium channel activity [Evidence IDA,IMP,ISS] [PMID 7651518]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IEA]; GO_function: GO:0005249 - voltage-gated potassium channel activity [Evidence IMP] [PMID 16133265]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IDA,IMP] [PMID 7651518]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IEA]; GO_process: GO:0034765 - regulation of ion transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
succinate dehydrogenase iron-sulfur protein subunit SDH2
similar to AA sequence:KEGG_Orthology:K00235
Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23509072]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IDA] [PMID 1939170]; GO_component: GO:0005749 - mitochondrial respiratory chain complex II [Evidence IDA] [PMID 9822678]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0051538 - 3 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IDA] [PMID 13445213]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IGI,IMP] [PMID 16232921]; GO_process: GO:0045333 - cellular respiration [Evidence IGI,IMP] [PMID 16232921]; GO_process: GO:0006121 - mitochondrial electron transport, succinate to ubiquinone [Evidence TAS] [PMID 9929002]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 10224250]
similar to AA sequence:KEGG_Orthology:K05609
Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1429680]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 1429680]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0010992 - ubiquitin homeostasis [Evidence IC] [PMID 1429680]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 21149575]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 19061648]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08657
transcription factor TFIIIC subunit TFC4
similar to AA sequence:KEGG_Orthology:K15201
similar to AA sequence:KEGG_Orthology:K00797
Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IMP,ISS] [PMID 9073064]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IMP] [PMID 9073064]
Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15078877]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15178413]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15078877]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15178413]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha
similar to AA sequence:KEGG_Orthology:K00161
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7589446]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016624 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IEA,IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IMP] [PMID 11589696]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]
similar to AA sequence:KEGG_Orthology:K07827
GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22575457]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22575457]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23127800]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20162532]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23127800]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 6438624]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8106517]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007190 - activation of adenylate cyclase activity [Evidence IDA] [PMID 8106517]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 2558958]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0000411 - positive regulation of transcription by galactose [Evidence IMP] [PMID 16292676]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 1547504]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 15917658]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12839995]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 8034612]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
Subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC2 has a paralog, VTC3, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17079729]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11823419]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0033254 - vacuolar transporter chaperone complex [Evidence IPI] [PMID 11823419]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016237 - microautophagy [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IGI,IMP] [PMID 11102525]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 10480897]; GO_process: GO:0007034 - vacuolar transport [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP,IPI] [PMID 11823419]
phosphatidylinositol-3-phosphate-binding protein BEM1
similar to AA sequence:KEGG_Orthology:K11237
similar to AA sequence:KEGG_Orthology:K01082
Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008441 - 3'(2'),5'-bisphosphate nucleotidase activity [Evidence IEA,IEA]; GO_function: GO:0008441 - 3'(2'),5'-bisphosphate nucleotidase activity [Evidence IDA] [PMID 7809627]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0042538 - hyperosmotic salinity response [Evidence IMP] [PMID 8393782]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 8393782]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 8910555]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10967
Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8631921]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IDA] [PMID 9020857]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9182588]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
similar to AA sequence:KEGG_Orthology:K03848
Alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IMP] [PMID 8877369]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0042281 - dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Evidence IMP] [PMID 10336995]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IMP] [PMID 8877369]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 15794922]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IMP] [PMID 10336995]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 8877369]
similar to AA sequence:KEGG_Orthology:K17797
Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 11950926]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0032977 - membrane insertase activity [Evidence IMP,ISS] [PMID 11950926]; GO_function: GO:0032977 - membrane insertase activity [Evidence IPI] [PMID 17452441]; GO_function: GO:0032977 - membrane insertase activity [Evidence IGI] [PMID 17922846]; GO_process: GO:0051205 - protein insertion into membrane [Evidence IEA]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IGI,IMP] [PMID 11950926]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IPI] [PMID 17452441]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IGI] [PMID 17922846]
similar to AA sequence:KEGG_Orthology:K10352
Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9442111]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9732290]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 9442111]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 9732290]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9732290]; GO_component: GO:0016460 - myosin II complex [Evidence IPI] [PMID 15210731]; GO_component: GO:0016459 - myosin complex [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000146 - microfilament motor activity [Evidence ISS] [PMID 9519900]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000915 - actomyosin contractile ring assembly [Evidence IMP] [PMID 9732290]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IMP] [PMID 16148042]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IEP] [PMID 9442111]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IEP] [PMID 9732290]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 12589071]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 3322809]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 9732290]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00872
Homoserine kinase; conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004413 - homoserine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004413 - homoserine kinase activity [Evidence IDA] [PMID 2165904]; GO_function: GO:0004413 - homoserine kinase activity [Evidence ISS] [PMID 8973190]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009092 - homoserine metabolic process [Evidence IDA] [PMID 2165904]; GO_process: GO:0006549 - isoleucine metabolic process [Evidence TAS] [PMID 8973190]; GO_process: GO:0006555 - methionine metabolic process [Evidence TAS] [PMID 8973190]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 17247984]; GO_process: GO:0006566 - threonine metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01412
Larger subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0017087 - mitochondrial processing peptidase complex [Evidence IDA] [PMID 2905264]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 2905264]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IMP] [PMID 3061808]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12275
Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03125
TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 11677244]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 8980232]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IDA,IMP] [PMID 15143185]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9844639]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 10713163]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12600943]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9288741]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9288742]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14830
Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 2826479]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17308036]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17308036]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI,IMP,IPI] [PMID 17308036]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 7739558]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13830
Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12852
GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720285]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 9233818]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP,ISS] [PMID 9233818]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 9848662]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IGI] [PMID 15911574]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 9233818]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IMP] [PMID 16540695]; GO_process: GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [Evidence IMP] [PMID 16540695]
similar to AA sequence:KEGG_Orthology:K14823
Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 21822217]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10849420]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000280 - nuclear division [Evidence IMP] [PMID 15515129]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 10849420]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
similar to AA sequence:KEGG_Orthology:K00787
Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19416104]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 19416104]; GO_function: GO:0004161 - dimethylallyltranstransferase activity [Evidence IEA]; GO_function: GO:0004161 - dimethylallyltranstransferase activity [Evidence IDA] [PMID 2681213]; GO_function: GO:0004337 - geranyltranstransferase activity [Evidence IEA]; GO_function: GO:0004337 - geranyltranstransferase activity [Evidence IDA] [PMID 2681213]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 1779710]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IDA] [PMID 2681213]; GO_process: GO:0033384 - geranyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IDA] [PMID 2681213]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14572
Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15528184]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12102729]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 12102729]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11583615]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 12374754]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 15528184]
RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IMP] [PMID 10716935]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI] [PMID 10716935]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 10716935]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IMP] [PMID 10716935]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
methylglyoxal reductase (NADPH-dependent) GRE2
similar to AA sequence:KEGG_Orthology:K17741
3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12206772]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12206772]; GO_function: GO:0046568 - 3-methylbutanol:NAD(P) oxidoreductase activity [Evidence IEA]; GO_function: GO:0046568 - 3-methylbutanol:NAD(P) oxidoreductase activity [Evidence IMP] [PMID 16999827]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0043892 - methylglyoxal reductase (NADPH-dependent) activity [Evidence IEA]; GO_function: GO:0043892 - methylglyoxal reductase (NADPH-dependent) activity [Evidence IDA] [PMID 12722185]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0008204 - ergosterol metabolic process [Evidence IGI,IMP] [PMID 16598690]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 16999827]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 18397879]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 14515169]; GO_component: GO:0005634 - nucleus [Evidence IGI] [PMID 18397879]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP] [PMID 14515169]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 18397879]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 18397879]; GO_process: GO:0008105 - asymmetric protein localization [Evidence IMP] [PMID 18397879]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 18397879]
hypothetical protein; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9121474]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9395535]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0046907 - intracellular transport [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 9636166]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 17904525]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 12082158]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05754
similar to AA sequence:KEGG_Orthology:K06874
Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9852145]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852145]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 17704259]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 12242280]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 9852145]
ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 11007476]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19061897]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070417 - cellular response to cold [Evidence IMP] [PMID 11855848]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 11063674]; GO_process: GO:0048255 - mRNA stabilization [Evidence IMP] [PMID 15220333]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11557770]; GO_process: GO:0061399 - positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion [Evidence IMP] [PMID 11509659]; GO_process: GO:0061419 - positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [Evidence IMP] [PMID 11509659]; GO_process: GO:0036083 - positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9927444]
similar to AA sequence:KEGG_Orthology:K03515
Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16452144]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16546083]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005657 - replication fork [Evidence IPI] [PMID 17517887]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 8751446]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0017125 - deoxycytidyl transferase activity [Evidence IDA] [PMID 8751446]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IMP] [PMID 10540291]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 8751446]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 17248528]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 8751446]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 9765213]
similar to AA sequence:KEGG_Orthology:K00873
Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14718557]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0030955 - potassium ion binding [Evidence IEA]; GO_function: GO:0004743 - pyruvate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004743 - pyruvate kinase activity [Evidence IDA] [PMID 12063246]; GO_function: GO:0004743 - pyruvate kinase activity [Evidence IMP] [PMID 323230]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 323230]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 323230]
similar to AA sequence:KEGG_Orthology:K00365
similar to AA sequence:KEGG_Orthology:K15084
Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11158296]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015228 - coenzyme A transmembrane transporter activity [Evidence IMP] [PMID 11158296]; GO_process: GO:0015880 - coenzyme A transport [Evidence IMP] [PMID 11158296]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0061503 - tRNA threonylcarbamoyladenosine dehydratase [Evidence IMP] [PMID 23242255]; GO_process: GO:0061504 - cyclic threonylcarbamoyladenosine biosynthetic process [Evidence IMP] [PMID 23242255]
Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; induces the appearance of the [PIN+] prion when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 23577202]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23577202]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034316 - negative regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA,IPI] [PMID 23577202]
similar to AA sequence:KEGG_Orthology:K14962
Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11805083]; GO_process: GO:0034729 - histone H3-K79 methylation [Evidence IMP] [PMID 18083099]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15146080]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 15146080]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 15146080]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IPI] [PMID 12819204]; GO_process: GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled [Evidence IPI] [PMID 12819204]
similar to AA sequence:KEGG_Orthology:K00868
Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008478 - pyridoxal kinase activity [Evidence IEA,IEA]; GO_function: GO:0008478 - pyridoxal kinase activity [Evidence ISA] [PMID 9099727]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009443 - pyridoxal 5'-phosphate salvage [Evidence IEA]; GO_process: GO:0042823 - pyridoxal phosphate biosynthetic process [Evidence IC] [PMID 9099727]
similar to AA sequence:KEGG_Orthology:K09537
Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1869583]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8144572]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 1869583]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 1400408]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9774392]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 10567418]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1473150]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IMP] [PMID 1729605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 19237599]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IGI,IMP] [PMID 11257114]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP,IPI] [PMID 12808034]
similar to AA sequence:KEGG_Orthology:K18158
Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 7723016]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IMP] [PMID 7723016]
hypothetical protein; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 19064668]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 8655575]; GO_component: GO:0070250 - mating projection membrane [Evidence IDA] [PMID 19064668]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070941 - eisosome assembly [Evidence IMP] [PMID 19564405]; GO_process: GO:0090002 - establishment of protein localization to plasma membrane [Evidence IMP] [PMID 20581291]; GO_process: GO:0001933 - negative regulation of protein phosphorylation [Evidence IMP] [PMID 19564405]; GO_process: GO:0007009 - plasma membrane organization [Evidence IMP] [PMID 19564405]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 8655575]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IDA] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
DNA-directed RNA polymerase I core subunit RPA190
similar to AA sequence:KEGG_Orthology:K02999
RNA polymerase I largest subunit A190; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15520468]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 3054507]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 2023944]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 3054507]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
dolichyl-phosphate-mannose-protein mannosyltransferase PMT1
similar to AA sequence:KEGG_Orthology:K00728
Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 22404710]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 22404710]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:2001172 - positive regulation of glucose catabolic process to ethanol [Evidence IMP] [PMID 8264540]; GO_process: GO:0090180 - positive regulation of thiamine biosynthetic process [Evidence IGI,IMP] [PMID 16850348]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19013460]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8264540]
similar to AA sequence:KEGG_Orthology:K14308
proteasome core particle subunit alpha 7
similar to AA sequence:KEGG_Orthology:K02727
Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
similar to AA sequence:KEGG_Orthology:K14152
Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004399 - histidinol dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004399 - histidinol dehydrogenase activity [Evidence IDA] [PMID 379004]; GO_function: GO:0004399 - histidinol dehydrogenase activity [Evidence IMP] [PMID 5919326]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity [Evidence IDA] [PMID 379004]; GO_function: GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity [Evidence IMP] [PMID 5919326]; GO_function: GO:0004636 - phosphoribosyl-ATP diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004636 - phosphoribosyl-ATP diphosphatase activity [Evidence IDA] [PMID 379004]; GO_function: GO:0004636 - phosphoribosyl-ATP diphosphatase activity [Evidence IMP] [PMID 5919326]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 5919326]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01759
Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004462 - lactoylglutathione lyase activity [Evidence IEA,IEA]; GO_function: GO:0004462 - lactoylglutathione lyase activity [Evidence IGI] [PMID 8824231]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IGI] [PMID 8824231]; GO_process: GO:0019243 - methylglyoxal catabolic process to D-lactate [Evidence IDA] [PMID 8824231]
Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 24855027]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12062425]; GO_function: GO:0004198 - calcium-dependent cysteine-type endopeptidase activity [Evidence IDA,IMP] [PMID 22761449]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IDA] [PMID 11983181]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16170310]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16301538]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 20624963]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03260
Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21925384]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence IGI,IMP,ISS] [PMID 8336723]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12810920]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence TAS] [PMID 9841679]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 12810920]
proteasome regulatory particle base subunit RPT6
similar to AA sequence:KEGG_Orthology:K03066
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10419517]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9287326]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA] [PMID 7870180]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 20855529]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 17167105]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI] [PMID 11410533]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IGI] [PMID 16269334]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0051091 - positive regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 16269334]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11389845]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 10688918]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11396
similar to AA sequence:KEGG_Orthology:K11429
Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9168472]; GO_component: GO:0010009 - cytoplasmic side of endosome membrane [Evidence IDA] [PMID 9168472]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 9168472]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI] [PMID 9335586]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI,IPI] [PMID 10021387]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IMP] [PMID 9168472]; GO_process: GO:0006906 - vesicle fusion [Evidence IMP] [PMID 9168472]
similar to AA sequence:KEGG_Orthology:K01772
Ferrochelatase; a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7629135]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IEA,IEA]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IDA] [PMID 1304908]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IMP] [PMID 2185242]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13519
Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17890783]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IEA]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IGI,IMP] [PMID 17675291]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IMP] [PMID 17726007]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IEA]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IMP] [PMID 17726007]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IMP] [PMID 17951629]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IDA,IMP] [PMID 17890783]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IGI,IMP] [PMID 17675291]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IMP] [PMID 17726007]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IMP] [PMID 17890783]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18932
Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 16647879]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031901 - early endosome membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 15632165]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 12370247]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IDA] [PMID 12370247]; GO_function: GO:0019706 - protein-cysteine S-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0018345 - protein palmitoylation [Evidence IDA] [PMID 12370247]; GO_process: GO:0018345 - protein palmitoylation [Evidence IDA,IMP] [PMID 16227572]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16751107]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 16227572]; GO_process: GO:0030100 - regulation of endocytosis [Evidence IMP] [PMID 10866691]; GO_process: GO:0010969 - regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI] [PMID 8524293]
Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004733 - pyridoxamine-phosphate oxidase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0042823 - pyridoxal phosphate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10733
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12768207]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IGI] [PMID 12730134]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12768207]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
acetyl-CoA:L-glutamate N-acetyltransferase
similar to AA sequence:KEGG_Orthology:K00618
Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 205532]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IDA,IMP] [PMID 11553611]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 11553611]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence IMP] [PMID 11553611]
similar to AA sequence:KEGG_Orthology:K12196
AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9606181]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 16601096]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 9606181]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 16505166]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 9155008]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9606181]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 18266866]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 9211789]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP,IPI] [PMID 9606181]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 16505166]; GO_process: GO:0051260 - protein homooligomerization [Evidence IDA] [PMID 9606181]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IGI,IMP] [PMID 16096648]; GO_process: GO:0006810 - transport [Evidence IEA]
Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07195
Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 18946089]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10207081]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 18946089]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 18195105]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17717527]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IPI] [PMID 10207081]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IDA] [PMID 10588647]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IPI] [PMID 19955214]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 17717527]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 17339375]; GO_process: GO:0007266 - Rho protein signal transduction [Evidence IDA,IGI,IPI] [PMID 19955214]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15583030]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 18946089]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 17717527]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 18946089]; GO_process: GO:0006887 - exocytosis [Evidence IEA,IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 15583030]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 17339375]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17717527]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
similar to AA sequence:KEGG_Orthology:K05532
Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10635561]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006486 - protein glycosylation [Evidence IDA,IMP] [PMID 10635561]
cyclin-dependent serine/threonine protein kinase SSN3
similar to AA sequence:KEGG_Orthology:K02208
similar to AA sequence:KEGG_Orthology:K08851
similar to AA sequence:KEGG_Orthology:K01183
Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11747810]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 1918080]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 1918080]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11914276]; GO_function: GO:0008061 - chitin binding [Evidence IEA]; GO_function: GO:0004568 - chitinase activity [Evidence IEA,IEA]; GO_function: GO:0008843 - endochitinase activity [Evidence IDA] [PMID 6799506]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IC] [PMID 3033651]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 1918080]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17878
S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 21858014]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0008112 - nicotinamide N-methyltransferase activity [Evidence IEA]; GO_function: GO:0008112 - nicotinamide N-methyltransferase activity [Evidence ISS] [PMID 12736687]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 12736687]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006769 - nicotinamide metabolic process [Evidence ISS] [PMID 12736687]; GO_process: GO:0006769 - nicotinamide metabolic process [Evidence IGI] [PMID 14724176]
similar to AA sequence:KEGG_Orthology:K06125
Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, is able to complement a yeast coq2 null mutant; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 359053]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10469659]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1740455]; GO_function: GO:0002083 - 4-hydroxybenzoate decaprenyltransferase activity [Evidence IEA]; GO_function: GO:0047293 - 4-hydroxybenzoate nonaprenyltransferase activity [Evidence IEA]; GO_function: GO:0008412 - 4-hydroxybenzoate octaprenyltransferase activity [Evidence IMP] [PMID 1740455]; GO_function: GO:0008412 - 4-hydroxybenzoate octaprenyltransferase activity [Evidence IGI] [PMID 7765507]; GO_function: GO:0008412 - 4-hydroxybenzoate octaprenyltransferase activity [Evidence ISS] [PMID 8155731]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IGI] [PMID 15548532]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 1740455]
Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]
similar to AA sequence:KEGG_Orthology:K03505
similar to AA sequence:KEGG_Orthology:K08157
TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11108
Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10790377]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003963 - RNA-3'-phosphate cyclase activity [Evidence ISS] [PMID 10790377]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 21849504]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16307926]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10790377]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10790377]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10790377]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17922
Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7862158]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21954159]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 7862158]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
proteasome regulatory particle lid subunit RPN7
similar to AA sequence:KEGG_Orthology:K03037
Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 15102831]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
similar to AA sequence:KEGG_Orthology:K00844
Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11311123]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9563516]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11311123]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9563516]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IEA,IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 12611889]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 332086]; GO_function: GO:0004396 - hexokinase activity [Evidence IMP] [PMID 6341351]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0032445 - fructose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006000 - fructose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0046323 - glucose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 332086]; GO_process: GO:0006096 - glycolytic process [Evidence IDA,IMP] [PMID 8917466]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0006013 - mannose metabolic process [Evidence IDA] [PMID 332086]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0046015 - regulation of transcription by glucose [Evidence IDA] [PMID 11311123]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15722108]
similar to AA sequence:KEGG_Orthology:K11369
Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10848632]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 12446794]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IDA,IGI,IMP] [PMID 7493987]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 12399373]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 7493987]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 8422683]; GO_process: GO:1900008 - negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging [Evidence IMP] [PMID 15020466]; GO_process: GO:0001079 - nitrogen catabolite regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11687605]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IGI,IMP] [PMID 7493987]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8422683]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP] [PMID 10848632]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP] [PMID 11076970]
Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01649
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 3275644]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3275644]; GO_function: GO:0003852 - 2-isopropylmalate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003852 - 2-isopropylmalate synthase activity [Evidence IDA] [PMID 3275644]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IGI] [PMID 10790691]
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IPI] [PMID 14690608]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 15485911]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA,IMP] [PMID 11238450]; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 22761830]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8707815]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IMP] [PMID 11238450]
similar to AA sequence:KEGG_Orthology:K07942
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; G protein of the Ras superfamily, similar to ADP-ribosylation factor; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077113]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15564045]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15975906]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15975906]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 23345439]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 9388248]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12210899]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IMP] [PMID 11840166]
similar to AA sequence:KEGG_Orthology:K03781
Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 14998369]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 1986244]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0004096 - catalase activity [Evidence IEA,IEA]; GO_function: GO:0004096 - catalase activity [Evidence IGI,IMP] [PMID 3897793]; GO_function: GO:0004096 - catalase activity [Evidence IDA] [PMID 9931255]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_process: GO:0001315 - age-dependent response to reactive oxygen species [Evidence IGI,IMP] [PMID 10705040]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IEA]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IGI,IMP] [PMID 3897793]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IDA] [PMID 9931255]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]; GO_process: GO:0000302 - response to reactive oxygen species [Evidence IMP] [PMID 15893481]
XP_964639|NADPH dehydrogenase [Neurospora crassa OR74A]
similar to AA sequence:KEGG_Orthology:K02984
Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01597
Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004163 - diphosphomevalonate decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004163 - diphosphomevalonate decarboxylase activity [Evidence IDA,IMP] [PMID 15169949]; GO_function: GO:0004163 - diphosphomevalonate decarboxylase activity [Evidence IMP] [PMID 1779710]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IMP] [PMID 9244250]
similar to AA sequence:KEGG_Orthology:K01535
Plasma membrane H+-ATPase; pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 10716729]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 15536122]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11739806]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IDA] [PMID 17912695]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:1902906 - proteasome storage granule assembly [Evidence IMP] [PMID 23690178]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006885 - regulation of pH [Evidence IEP] [PMID 8929277]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006810 - transport [Evidence IEA]
Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K15177
Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 20732871]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 20732871]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IMP] [PMID 20732871]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 11927560]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000321 - re-entry into mitotic cell cycle after pheromone arrest [Evidence IMP] [PMID 16510898]
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3
similar to AA sequence:KEGG_Orthology:K00134
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria; TDH3 has a paralog, TDH2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11158358]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11158358]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IPI] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IDA] [PMID 3905788]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17726063]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 3905788]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEP] [PMID 3905788]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0072593 - reactive oxygen species metabolic process [Evidence IMP] [PMID 17726063]
Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IDA] [PMID 10855721]; GO_process: GO:0006083 - acetate metabolic process [Evidence IDA] [PMID 10855721]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K09780
Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03132
TFIID subunit (67 kDa); involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15267
Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; GO_component: GO:0034245 - mitochondrial DNA-directed RNA polymerase complex [Evidence IDA] [PMID 7929382]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 12270918]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 12270918]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0034246 - mitochondrial RNA polymerase binding promoter specificity activity [Evidence IDA] [PMID 20008320]; GO_function: GO:0034246 - mitochondrial RNA polymerase binding promoter specificity activity [Evidence IDA,IPI] [PMID 7929382]; GO_function: GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity [Evidence IEA]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006391 - transcription initiation from mitochondrial promoter [Evidence IDA] [PMID 19920143]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Sar family guanine nucleotide exchange factor SEC12
RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23028530]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23028530]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI] [PMID 23028530]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 23028530]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15160
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA] [PMID 20308326]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12482986]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12558798]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07573
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11027292]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA,IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11027292]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IGI,IMP] [PMID 11027292]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IGI,IMP] [PMID 19060898]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0032174 - cellular bud neck septin collar [Evidence IDA] [PMID 15901837]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15901837]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 15901837]; GO_component: GO:0005940 - septin ring [Evidence IDA,IPI] [PMID 9314530]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12529424]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9314530]; GO_process: GO:0008105 - asymmetric protein localization [Evidence IDA,IMP] [PMID 12529424]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI] [PMID 15470103]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IGI,IMP] [PMID 15470103]
Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 20124025]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 20124025]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IMP] [PMID 19562342]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000963 - mitochondrial RNA processing [Evidence IMP] [PMID 19562342]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 19751518]; GO_process: GO:0016072 - rRNA metabolic process [Evidence IMP] [PMID 20124025]
Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 15507444]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11498004]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 11498004]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8702496]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 11498004]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 15507444]
similar to AA sequence:KEGG_Orthology:K01895
Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16857587]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9711835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19618123]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16857587]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19618123]; GO_function: GO:0016208 - AMP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IEA,IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IDA] [PMID 8910545]; GO_function: GO:0016880 - acid-ammonia (or amide) ligase activity [Evidence IDA] [PMID 18305111]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006085 - acetyl-CoA biosynthetic process [Evidence IDA] [PMID 8910545]; GO_process: GO:0019427 - acetyl-CoA biosynthetic process from acetate [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 16857587]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 19618123]
Putative transcription factor; has homolog in Kluyveromyces lactis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
proteasome regulatory particle lid subunit RPN8
similar to AA sequence:KEGG_Orthology:K03038
Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
similar to AA sequence:KEGG_Orthology:K14789
rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 21282979]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17425675]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 21282979]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 21893585]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI] [PMID 17425675]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04392
Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8167411]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8167411]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 23906065]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 22323294]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 23468594]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10066831]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 11003652]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IMP] [PMID 11595741]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI,IPI] [PMID 19955214]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IMP] [PMID 12234925]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11595741]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 14734532]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IMP] [PMID 14517318]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06883
Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 23267056]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:1990022 - RNA polymerase III complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 18439903]
similar to AA sequence:KEGG_Orthology:K14171
Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10681558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IMP] [PMID 12270680]
AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI] [PMID 16687571]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 16687571]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IGI,IMP] [PMID 16687571]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01173
Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 17244531]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 3286639]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17244531]; GO_function: GO:0004520 - endodeoxyribonuclease activity [Evidence IDA] [PMID 3286639]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004529 - exodeoxyribonuclease activity [Evidence IDA] [PMID 3286639]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004540 - ribonuclease activity [Evidence IDA] [PMID 3286639]; GO_process: GO:0006308 - DNA catabolic process [Evidence IDA] [PMID 3286639]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 8087883]; GO_process: GO:0006401 - RNA catabolic process [Evidence IDA] [PMID 3286639]; GO_process: GO:0006309 - apoptotic DNA fragmentation [Evidence IMP] [PMID 22727375]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17244531]
Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10077572]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IEA]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IDA] [PMID 10600176]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 10077572]
similar to AA sequence:KEGG_Orthology:K15505
DNA helicase/Ubiquitin ligase; involved in error-free branch of DNA damage tolerance (DDT) pathway; proposed to promote replication fork regression during postreplication repair by template switching; stimulates synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress; associates with native telomeres, cooperates with homologous recombination in senescent cells; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IDA] [PMID 24393774]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10880451]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 17936713]; GO_function: GO:0000403 - Y-form DNA binding [Evidence IDA] [PMID 17936713]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 17936713]; GO_function: GO:0009378 - four-way junction helicase activity [Evidence IDA] [PMID 17936713]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI,IMP] [PMID 16224103]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 23142547]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IDA] [PMID 19706603]; GO_process: GO:0006301 - postreplication repair [Evidence IDA] [PMID 17936713]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 19706603]
Mucin family member that functions as an osmosensor in the HOG pathway; functions in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,ISS] [PMID 8550469]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 17627274]; GO_function: GO:0005034 - osmosensor activity [Evidence IGI] [PMID 17627274]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8550469]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 8550469]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 8550469]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 17627274]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IGI,IPI] [PMID 17627274]
Disintegrin and metalloproteinase domain-containing protein 30
actin cortical patch component, with EF hand and WH2 motif Panl (predicted)
similar to AA sequence:KEGG_Orthology:K08288
Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 16373354]; GO_component: GO:0017177 - glucosidase II complex [Evidence IPI] [PMID 16373354]; GO_function: GO:0004558 - alpha-glucosidase activity [Evidence IMP] [PMID 16373354]; GO_function: GO:0004558 - alpha-glucosidase activity [Evidence IMP] [PMID 19542522]; GO_process: GO:0006491 - N-glycan processing [Evidence IEA]; GO_process: GO:0000271 - polysaccharide biosynthetic process [Evidence IMP] [PMID 16373354]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 16373354]
similar to AA sequence:KEGG_Orthology:K12813
RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA,IMP] [PMID 2251118]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA,IMP] [PMID 8112302]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA,IMP] [PMID 8430102]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 1534753]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IDA] [PMID 8943336]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 24442613]
proteasome regulatory particle lid subunit RPN5
similar to AA sequence:KEGG_Orthology:K03035
Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN; GO_component: GO:0008180 - COP9 signalosome [Evidence IDA] [PMID 21289098]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 21289098]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 21289098]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
similar to AA sequence:KEGG_Orthology:K00354
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 7836424]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14548
Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03023
RNA polymerase III subunit C82; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 1406632]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
serine/threonine protein kinase regulatory subunit ATG13
similar to AA sequence:KEGG_Orthology:K08331
Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
hypothetical protein; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 15651983]; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 12388763]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15651983]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 18298676]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18298676]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI] [PMID 12388763]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 12388763]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 10512884]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 12388763]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]
DNA-directed RNA polymerase II core subunit RPB2
similar to AA sequence:KEGG_Orthology:K03010
RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0032549 - ribonucleoside binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2406558]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18423
Nuclear envelope protein that mediates the nuclear export of Srp1p; Srp1p (importin alpha) is a homolog of metazoan CAS protein; required for accurate chromosome segregation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 9857050]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008262 - importin-alpha export receptor activity [Evidence IGI,IPI,ISS] [PMID 9857050]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IGI,IPI] [PMID 9857050]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14784
Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K14553
Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 15585575]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 15585575]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 15585575]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 22685415]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 15585575]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IGI,IMP] [PMID 17984322]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IMP] [PMID 15911569]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI,IMP] [PMID 17984322]
similar to AA sequence:KEGG_Orthology:K14774
Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 20528918]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20528918]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IPI] [PMID 20528918]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 20884785]; GO_function: GO:0034511 - U3 snoRNA binding [Evidence IDA] [PMID 20528918]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 20528918]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 20528918]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 20884785]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP,IPI] [PMID 19806183]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20528918]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20884785]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01254
Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA] [PMID 10574934]; GO_function: GO:0004301 - epoxide hydrolase activity [Evidence IDA] [PMID 10574934]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004463 - leukotriene-A4 hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004463 - leukotriene-A4 hydrolase activity [Evidence ISS] [PMID 10341423]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10341423]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IDA] [PMID 10574934]; GO_process: GO:0019370 - leukotriene biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IDA] [PMID 10574934]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00764
Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribosyltransferase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence IDA,IMP] [PMID 11689683]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence IMP] [PMID 6376509]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 11689683]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
putative tyrosine protein phosphatase MIH1
similar to AA sequence:KEGG_Orthology:K02555
similar to AA sequence:KEGG_Orthology:K14555
Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09829
C-8 sterol isomerase; catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IC] [PMID 18459942]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000247 - C-8 sterol isomerase activity [Evidence IMP] [PMID 18459942]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 18459942]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
SAGA histone acetyltransferase complex subunit SPT7
similar to AA sequence:KEGG_Orthology:K11359
Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 12101232]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 9858534]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 7713415]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 12101232]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 9858534]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10088
ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IPI] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 16168371]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0034099 - luminal surveillance complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0070492 - oligosaccharide binding [Evidence IDA] [PMID 19111666]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16168370]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16168371]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16168372]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22298424]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22298424]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 24292014]
mitochondrial 54S ribosomal protein YmL35
similar to AA sequence:KEGG_Orthology:K17439
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
similar to AA sequence:KEGG_Orthology:K06027
AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor (NSF); GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 23613772]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 10387016]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 2071670]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IDA] [PMID 9382859]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 18650938]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 9425154]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11694599]; GO_process: GO:0048219 - inter-Golgi cisterna vesicle-mediated transport [Evidence IMP] [PMID 10637300]; GO_process: GO:0048219 - inter-Golgi cisterna vesicle-mediated transport [Evidence IMP] [PMID 2071670]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 8670830]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 9685264]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IDA] [PMID 9382859]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
NADH:ubiquinone oxidoreductase 18.4kD subunit
similar to AA sequence:KEGG_Orthology:K03939
similar to AA sequence:KEGG_Orthology:K15165
similar to AA sequence:KEGG_Orthology:K14347
similar to AA sequence:KEGG_Orthology:K02265
Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IPI] [PMID 1331058]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 1331058]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 7851399]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 17215247]; GO_process: GO:0009060 - aerobic respiration [Evidence IPI] [PMID 163235]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen [Evidence IDA] [PMID 1331058]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006119 - oxidative phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02976
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11756
Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 14729968]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 16024655]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IPI] [PMID 15870268]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 12024034]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IMP] [PMID 14729968]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_component: GO:0005773 - vacuole [Evidence IDA] [PMID 23222640]; GO_function: GO:0015926 - glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IGI] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
saccharopine dehydrogenase (NADP+, L-glutamate-forming)
similar to AA sequence:KEGG_Orthology:K00293
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004755 - saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [Evidence IEA]; GO_function: GO:0004755 - saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [Evidence IDA] [PMID 18416559]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 6429126]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12849
Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA,IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 12045225]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IGI,IMP] [PMID 18694928]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IDA] [PMID 23919454]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006037 - cell wall chitin metabolic process [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0071555 - cell wall organization [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 18694928]
putative serine/threonine protein kinase KIN4
Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to the M28 family of metalloproteases; has a lumenal-facing protease domain; proposed role in vacuole physiology; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23679341]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K13993
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IPI] [PMID 8576246]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 8576246]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IGI,IMP] [PMID 9199338]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01599
Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004853 - uroporphyrinogen decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004853 - uroporphyrinogen decarboxylase activity [Evidence IDA] [PMID 2180703]; GO_function: GO:0004853 - uroporphyrinogen decarboxylase activity [Evidence IMP] [PMID 7035824]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 1471989]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]
hypothetical protein; similar to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae; expresses a circular RNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence ISS] [PMID 15225602]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17805
Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 14981506]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14981506]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14981507]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA] [PMID 16105940]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP,IPI] [PMID 14981506]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP,IPI] [PMID 14981507]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14801
Cytoplasmic protein required for correct processing of 20S pre-rRNA; protein required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 19806183]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02519
Mitochondrial translation initiation factor 2; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 1935960]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 12729623]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 12729623]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 15935987]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISA] [PMID 1935960]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1935960]; GO_process: GO:0070124 - mitochondrial translational initiation [Evidence IC] [PMID 15935987]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence ISA] [PMID 1935960]
protein serine/threonine kinase activating protein DBF4
similar to AA sequence:KEGG_Orthology:K02309
similar to AA sequence:KEGG_Orthology:K03809
Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/bacterial pantothenate kinase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18004758]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence ISS] [PMID 18004758]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence ISS] [PMID 18004758]
similar to AA sequence:KEGG_Orthology:K03522
Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00818
Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 205532]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003992 - N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [Evidence IEA]; GO_function: GO:0003992 - N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [Evidence IDA] [PMID 2199330]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 12603335]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence TAS] [PMID 205532]
similar to AA sequence:KEGG_Orthology:K18696
Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0047389 - glycerophosphocholine phosphodiesterase activity [Evidence IMP,ISS] [PMID 16141200]; GO_function: GO:0008889 - glycerophosphodiester phosphodiesterase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0046475 - glycerophospholipid catabolic process [Evidence IMP,ISS] [PMID 16141200]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10858
ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL; GO_component: GO:0032389 - MutLalpha complex [Evidence IEA]; GO_component: GO:0032389 - MutLalpha complex [Evidence IPI] [PMID 10570173]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 10938116]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 11717305]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0032139 - dinucleotide insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 2685551]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K10755
Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA] [PMID 8202350]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12912927]; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23613772]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0017076 - purine nucleotide binding [Evidence ISS] [PMID 7651383]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IMP] [PMID 9671499]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0006298 - mismatch repair [Evidence TAS] [PMID 10072354]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IPI] [PMID 11389843]
similar to AA sequence:KEGG_Orthology:K14539
Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12773575]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 12773575]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 16209721]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10669874]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 10669874]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 20670889]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP,IPI] [PMID 12773575]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08507
Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p; GO_component: GO:0031201 - SNARE complex [Evidence IDA,ISM] [PMID 12853481]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0071458 - integral component of cytoplasmic side of endoplasmic reticulum membrane [Evidence IDA] [PMID 12893879]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISA] [PMID 12853481]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 12853481]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 12893879]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048279 - vesicle fusion with endoplasmic reticulum [Evidence IC] [PMID 12853481]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06678
Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000796 - condensin complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IGI,ISS] [PMID 10749931]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IGI] [PMID 11864994]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IMP] [PMID 14662740]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IMP] [PMID 14662740]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IGI] [PMID 10749931]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11864994]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 11864994]; GO_process: GO:0070550 - rDNA condensation [Evidence IMP] [PMID 18708580]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 14662740]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
ubiquinol--cytochrome-c reductase subunit 2
similar to AA sequence:KEGG_Orthology:K00415
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 19019989]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IMP] [PMID 3028797]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3028797]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IDA] [PMID 3028797]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
SKI complex subunit tetratricopeptide repeat protein SKI3
similar to AA sequence:KEGG_Orthology:K12600
Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome; GO_component: GO:0055087 - Ski complex [Evidence IDA] [PMID 10744028]; GO_component: GO:0055087 - Ski complex [Evidence IDA,IPI] [PMID 18042677]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 10611222]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]
similar to AA sequence:KEGG_Orthology:K06664
similar to AA sequence:KEGG_Orthology:K10747
DNA ligase found in the nucleus and mitochondria; an essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 10531002]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10531002]; GO_component: GO:0005657 - replication fork [Evidence NAS] [PMID 9759502]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA] [PMID 1445910]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA] [PMID 6347688]; GO_function: GO:0003909 - DNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006266 - DNA ligation [Evidence IDA,IMP] [PMID 9759502]; GO_process: GO:0051103 - DNA ligation involved in DNA repair [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 9230305]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IMP] [PMID 10052932]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006273 - lagging strand elongation [Evidence IDA,IMP] [PMID 9759502]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 16079237]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749599]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 10052932]
putative serine/threonine protein kinase VHS1
similar to AA sequence:KEGG_Orthology:K06639
Protein phosphatase required for mitotic exit; required for rDNA segregation; located in nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis; GO_component: GO:0030869 - RENT complex [Evidence IDA] [PMID 10219244]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12062061]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12062061]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 24319056]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 9295359]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0008138 - protein tyrosine/serine/threonine phosphatase activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051304 - chromosome separation [Evidence IMP] [PMID 16769819]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0051229 - meiotic spindle disassembly [Evidence IMP] [PMID 12737806]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749599]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 20923974]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 9295359]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IGI,IPI] [PMID 10219244]
Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9988704]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031235 - intrinsic component of the cytoplasmic side of the plasma membrane [Evidence IDA] [PMID 17679730]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IMP] [PMID 9660783]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0005324 - long-chain fatty acid transporter activity [Evidence IMP] [PMID 9079682]; GO_function: GO:0031957 - very long-chain fatty acid-CoA ligase activity [Evidence IMP] [PMID 9660783]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0015909 - long-chain fatty acid transport [Evidence IMP] [PMID 10880966]; GO_process: GO:0015909 - long-chain fatty acid transport [Evidence IGI,IMP] [PMID 12601005]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000038 - very long-chain fatty acid metabolic process [Evidence IMP] [PMID 9660783]; GO_process: GO:0000038 - very long-chain fatty acid metabolic process [Evidence IMP] [PMID 9988704]
similar to AA sequence:KEGG_Orthology:K00052
Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 4355481]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IDA] [PMID 3071718]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IMP] [PMID 6297759]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 23642236]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 6297759]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Essential RNA-binding G protein effector of mating response pathway; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23222640]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11278502]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 8533468]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 11278502]; GO_function: GO:0001965 - G-protein alpha-subunit binding [Evidence IPI] [PMID 14536090]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 11278502]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16632467]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI,IMP] [PMID 16632467]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8533468]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IPI] [PMID 11278502]; GO_process: GO:0045141 - meiotic telomere clustering [Evidence IMP] [PMID 16632467]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI] [PMID 14536090]
Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISA] [PMID 16845689]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IMP] [PMID 16845689]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015856 - cytosine transport [Evidence IMP] [PMID 16845689]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0072530 - purine-containing compound transmembrane transport [Evidence ISA] [PMID 16845689]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01705
Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence ISA] [PMID 9268014]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 2507177]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08266
Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 12631735]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IMP] [PMID 16002396]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 12719473]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 12408816]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 12719473]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 11742997]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 12719473]; GO_process: GO:0006810 - transport [Evidence IMP] [PMID 9409822]
similar to AA sequence:KEGG_Orthology:K14327
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16043493]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 9268361]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 23390378]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12881429]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 15388879]
similar to AA sequence:KEGG_Orthology:K17508
Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11327310]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18180296]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19564484]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 19564484]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 23940037]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 12220683]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 23940037]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 23940037]
Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IC] [PMID 9643541]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 19767828]
similar to AA sequence:KEGG_Orthology:K14016
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP); GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11733065]; GO_function: GO:0031593 - polyubiquitin binding [Evidence IDA] [PMID 16004872]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16004872]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11813000]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
galactose-responsive transcription factor GAL4
similar to AA sequence:KEGG_Orthology:K09241
similar to AA sequence:KEGG_Orthology:K01053
similar to AA sequence:KEGG_Orthology:K05535
Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9756928]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9756928]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9756928]
similar to AA sequence:KEGG_Orthology:K00008
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IEA]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IDA,ISS] [PMID 8125328]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEP] [PMID 8125328]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00451
similar to AA sequence:KEGG_Orthology:K10438
bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence ISM] [PMID 1551874]; GO_function: GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004300 - enoyl-CoA hydratase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 10497229]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 1551874]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01555
similar to AA sequence:KEGG_Orthology:K07178
hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans; GO_component: GO:0036266 - Cdc48p-Npl4p-Vms1p AAA ATPase complex [Evidence IDA] [PMID 21070972]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 21070972]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 21148305]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 21070972]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21148305]; GO_process: GO:0072671 - mitochondria-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21070972]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22718752]
similar to AA sequence:KEGG_Orthology:K10877
DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA and promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis and meiosis; phosphorylated in Mec1p-, Rad53p-dependent way in response to one DSB; contributes to remodelling of nucleosomes; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 16831867]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 10970884]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 10970884]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IMP] [PMID 16831867]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA,IMP] [PMID 16831867]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IDA,IMP] [PMID 16831867]; GO_process: GO:0032392 - DNA geometric change [Evidence IDA] [PMID 10970884]; GO_process: GO:0032392 - DNA geometric change [Evidence IDA,IMP] [PMID 16831867]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 16831867]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 16831867]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 10970884]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0045144 - meiotic sister chromatid segregation [Evidence IMP] [PMID 16230461]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP] [PMID 9409819]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP] [PMID 9409820]
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12524434]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 8660468]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22129104]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 18675371]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11533229]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 18675371]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 16055745]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11533229]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16055745]; GO_process: GO:0035969 - positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 11208779]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01180
Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; GO_component: GO:0030428 - cell septum [Evidence IDA] [PMID 12455695]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence ISS] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11935221]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence IGI] [PMID 12455695]; GO_function: GO:0052861 - glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0052862 - glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0016998 - cell wall macromolecule catabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IEP,ISS] [PMID 11747810]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 16328626]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000784 - nuclear chromosome, telomeric region [Evidence IDA] [PMID 20513435]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 20513435]; GO_function: GO:0000982 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 20513435]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0043035 - chromatin insulator sequence binding [Evidence IDA] [PMID 11258704]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 20513435]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IDA] [PMID 11258704]; GO_process: GO:0032211 - negative regulation of telomere maintenance via telomerase [Evidence IGI] [PMID 16467854]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IDA,IMP] [PMID 20513435]; GO_process: GO:0010833 - telomere maintenance via telomere lengthening [Evidence IDA] [PMID 17917674]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01012
Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004076 - biotin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004076 - biotin synthase activity [Evidence IMP] [PMID 10525840]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IMP] [PMID 10525840]
Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; YPS1 has a paralog, MKC7, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA] [PMID 8389368]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 8626758]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01836
Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016868 - intramolecular transferase activity, phosphotransferases [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004610 - phosphoacetylglucosamine mutase activity [Evidence IEA,IEA]; GO_function: GO:0004610 - phosphoacetylglucosamine mutase activity [Evidence IMP,ISS] [PMID 8174553]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IBA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IBA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 8174553]; GO_process: GO:0019255 - glucose 1-phosphate metabolic process [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K11558
Cytoplasmic hypothetical protein; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K00958
ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004781 - sulfate adenylyltransferase (ATP) activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004781 - sulfate adenylyltransferase (ATP) activity [Evidence IDA] [PMID 10092498]; GO_function: GO:0004781 - sulfate adenylyltransferase (ATP) activity [Evidence IMP] [PMID 197388]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IEA,IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IMP] [PMID 197388]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IEA]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
ubiquitin-protein transferase activating protein CDC20
similar to AA sequence:KEGG_Orthology:K03363
similar to AA sequence:KEGG_Orthology:K19704
Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11113180]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11113180]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 10580002]; GO_process: GO:0000173 - inactivation of MAPK activity involved in osmosensory signaling pathway [Evidence IDA,IGI,IMP] [PMID 11113180]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP] [PMID 9529388]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 20400943]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 10580002]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 11113180]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IMP] [PMID 8196609]
AMP-activated serine/threonine-protein kinase regulatory subunit SNF4
Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA] [PMID 12393914]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA,IPI] [PMID 2481228]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 9121458]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17237508]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 2481228]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 17237508]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17237508]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 2481228]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562756]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 11486005]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IGI,IMP] [PMID 2557546]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 7913470]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043539 - protein serine/threonine kinase activator activity [Evidence IMP] [PMID 11486005]; GO_function: GO:0043539 - protein serine/threonine kinase activator activity [Evidence IGI,IMP] [PMID 2557546]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IMP] [PMID 1355328]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP,IPI] [PMID 2481228]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 11486005]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 2557546]; GO_process: GO:0006468 - protein phosphorylation [Evidence IGI,IMP] [PMID 7913470]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 2557546]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 10921902]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09580
Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 1761554]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP] [PMID 11157982]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16413482]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16002399]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 11157982]
Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 17261844]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 17261844]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA,IMP] [PMID 17261844]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10417390]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 17261844]; GO_process: GO:0007030 - Golgi organization [Evidence ISS] [PMID 10417390]; GO_process: GO:0009306 - protein secretion [Evidence IMP] [PMID 20156967]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IPI] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02331
DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12093911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA,ISS] [PMID 12093911]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 12093911]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 12093911]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02021
Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis; GO_component: GO:0016021 - integral component of membrane [Evidence IBA,IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11251115]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IRD]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 23509072]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence IBA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence ISA] [PMID 11251115]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IDA] [PMID 23509072]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090374 - oligopeptide export from mitochondrion [Evidence ISA] [PMID 11251115]; GO_process: GO:0006857 - oligopeptide transport [Evidence ISA] [PMID 11251115]; GO_process: GO:0055085 - transmembrane transport [Evidence IBA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14530
similar to AA sequence:KEGG_Orthology:K14191
Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 8064863]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0052909 - 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))- dimethyltransferase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IEA]; GO_function: GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity [Evidence IEA]; GO_function: GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity [Evidence ISS] [PMID 8064863]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8064863]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA,IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IMP] [PMID 8064863]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05841
UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016906 - sterol 3-beta-glucosyltransferase activity [Evidence IEA]; GO_function: GO:0016906 - sterol 3-beta-glucosyltransferase activity [Evidence IDA] [PMID 10224056]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0032120 - ascospore-type prospore membrane assembly [Evidence IGI] [PMID 18756268]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0030259 - lipid glycosylation [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 10224056]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08488
transcription factor TFIIIC subunit TFC3
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
similar to AA sequence:KEGG_Orthology:K07748
C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11279045]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12119386]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003854 - 3-beta-hydroxy-delta5-steroid dehydrogenase activity [Evidence IEA]; GO_function: GO:0000252 - C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [Evidence IDA] [PMID 9811880]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0047012 - sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 9811880]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15130
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 12054864]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0001106 - RNA polymerase II transcription corepressor activity [Evidence IPI] [PMID 16528100]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 16964259]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 18381891]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15705057]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18381891]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02685
Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:1990077 - primosome complex [Evidence IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3061469]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3888995]; GO_function: GO:0003896 - DNA primase activity [Evidence IGI,IMP] [PMID 8436268]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 20404922]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 2023935]; GO_process: GO:0006270 - DNA replication initiation [Evidence IC] [PMID 3888995]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IEA,IEA]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IDA] [PMID 2644256]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 10025407]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IEA]; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IDA,IPI] [PMID 7828851]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7828851]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 16215174]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IC] [PMID 7828851]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12614847]; GO_process: GO:0043457 - regulation of cellular respiration [Evidence IGI] [PMID 7828851]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13577
Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 15591051]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0005310 - dicarboxylic acid transmembrane transporter activity [Evidence IDA] [PMID 9020177]; GO_function: GO:0005310 - dicarboxylic acid transmembrane transporter activity [Evidence IDA] [PMID 9559855]; GO_process: GO:0006835 - dicarboxylic acid transport [Evidence IDA] [PMID 9020177]; GO_process: GO:0006835 - dicarboxylic acid transport [Evidence IDA] [PMID 9559855]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
phosphatidylinositol kinase-related protein kinase TOR1
similar to AA sequence:KEGG_Orthology:K07203
PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16900101]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 12631735]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16900101]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10973982]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008144 - drug binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_function: GO:0004672 - protein kinase activity [Evidence IMP] [PMID 10329624]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 12719473]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 8186460]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 17698581]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 14736892]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 9096347]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 11997479]; GO_process: GO:0010507 - negative regulation of autophagy [Evidence IGI] [PMID 9461583]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 8741837]; GO_process: GO:0001558 - regulation of cell growth [Evidence TAS] [PMID 11057898]; GO_process: GO:0001558 - regulation of cell growth [Evidence IMP] [PMID 12171921]; GO_process: GO:0090153 - regulation of sphingolipid biosynthetic process [Evidence IMP] [PMID 23363605]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 10198052]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 8741837]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 16900101]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 8741837]
phosphatidylinositol kinase-related protein kinase TOR2
PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18723607]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 12631735]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8846782]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10973982]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008144 - drug binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 16055732]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 12719473]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 8186460]; GO_process: GO:0030037 - actin filament reorganization involved in cell cycle [Evidence TAS] [PMID 9038344]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IMP] [PMID 9475724]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 12408816]; GO_process: GO:0010507 - negative regulation of autophagy [Evidence IGI] [PMID 9461583]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:2001108 - positive regulation of Rho guanyl-nucleotide exchange factor activity [Evidence IGI,IMP] [PMID 9038344]; GO_process: GO:0035025 - positive regulation of Rho protein signal transduction [Evidence IGI,IMP] [PMID 9038344]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0051726 - regulation of cell cycle [Evidence TAS] [PMID 9475724]; GO_process: GO:0001558 - regulation of cell growth [Evidence TAS] [PMID 11057898]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 10198052]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 8186460]
similar to AA sequence:KEGG_Orthology:K14796
Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17425675]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI] [PMID 17425675]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
translation termination factor GTPase eRF3
similar to AA sequence:KEGG_Orthology:K03267
Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23451152]; GO_component: GO:0018444 - translation release factor complex [Evidence IDA] [PMID 7556078]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003747 - translation release factor activity [Evidence IEA]; GO_function: GO:0003747 - translation release factor activity [Evidence IDA] [PMID 20947765]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP,IPI] [PMID 12923185]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IDA] [PMID 20947765]
similar to AA sequence:KEGG_Orthology:K04513
GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p); GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 8602515]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 1918143]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8195291]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8195291]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8195291]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12660244]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15596542]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 7962098]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 15596542]; GO_process: GO:0031532 - actin cytoskeleton reorganization [Evidence IGI,IPI] [PMID 8947028]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 8195291]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IDA,IMP] [PMID 8621575]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IGI,IPI] [PMID 8846785]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8602514]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8602515]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8662910]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11283608]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 8621575]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10893184]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IDA] [PMID 8621575]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IGI] [PMID 8846785]
Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 15689497]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15372071]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15689497]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence TAS] [PMID 15372071]; GO_process: GO:0031929 - TOR signaling [Evidence IPI] [PMID 15689497]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15372071]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15689497]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI] [PMID 15689497]; GO_process: GO:0070941 - eisosome assembly [Evidence IGI] [PMID 21451250]; GO_process: GO:0016197 - endosomal transport [Evidence IGI] [PMID 21451250]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 15689497]; GO_process: GO:0001558 - regulation of cell growth [Evidence IGI,IPI] [PMID 15689497]
similar to AA sequence:KEGG_Orthology:K17619
Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 22553209]; GO_function: GO:0005525 - GTP binding [Evidence IDA,IMP] [PMID 22553209]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 22553209]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IMP] [PMID 22553209]
secretory pathway protein Pga2 (predicted)
similar to AA sequence:KEGG_Orthology:K15109
Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16140254]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IGI,ISS] [PMID 16140254]; GO_process: GO:0006839 - mitochondrial transport [Evidence IGI] [PMID 16140254]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI,ISS] [PMID 16140254]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13354
Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16291748]; GO_function: GO:0051724 - NAD transporter activity [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IMP] [PMID 12887330]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IDA] [PMID 16291748]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10930523]; GO_process: GO:0035352 - NAD transmembrane transport [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IMP] [PMID 12887330]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IDA] [PMID 16291748]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10930523]
similar to AA sequence:KEGG_Orthology:K05284
Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence ISS] [PMID 11226175]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 11226175]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence ISS] [PMID 11226175]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 16134120]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 16134120]
inositol phosphosphingolipid phospholipase
similar to AA sequence:KEGG_Orthology:K12351
Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14699160]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 17880915]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14699160]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0052712 - inositol phosphosphingolipid phospholipase activity [Evidence IDA] [PMID 11006294]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 17880915]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 23620586]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 12180980]; GO_process: GO:0030149 - sphingolipid catabolic process [Evidence IDA] [PMID 11006294]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17900
similar to AA sequence:KEGG_Orthology:K14262
Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17179087]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016805 - dipeptidase activity [Evidence IEA]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IDA,IMP] [PMID 22277648]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008242 - omega peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IGI] [PMID 17179087]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 17179087]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IDA,IMP] [PMID 22277648]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8625407]; GO_function: GO:0017022 - myosin binding [Evidence IDA] [PMID 12725728]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence TAS] [PMID 10792032]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 11553699]; GO_process: GO:0007533 - mating type switching [Evidence IMP] [PMID 8625407]
aldolase, putative class II aldolase/adducin domain protein, putative
similar to AA sequence:KEGG_Orthology:K09458
Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence IEA]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence ISA] [PMID 15668256]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence ISA] [PMID 15668256]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12411
Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 12464633]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA] [PMID 20385087]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IPI] [PMID 12464633]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IMP,IPI] [PMID 20385087]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 12464633]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17314407]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17287526]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 15590673]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 17287526]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 17287526]
similar to AA sequence:KEGG_Orthology:K15334
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9767141]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IDA] [PMID 10445884]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 17567576]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IMP] [PMID 22760636]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10445884]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0002127 - wobble base cytosine methylation [Evidence IMP] [PMID 22760636]
similar to AA sequence:KEGG_Orthology:K11884
Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10923024]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12502737]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA,IPI] [PMID 12502737]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12736301]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12736301]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP,IPI] [PMID 12502737]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15175
Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homologue, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 9032243]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 11983171]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 11884586]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 9032243]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_function: GO:0001089 - TFIIF-class binding transcription factor activity [Evidence IMP,IPI] [PMID 9032243]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11983171]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IMP] [PMID 9891041]; GO_process: GO:2001255 - positive regulation of histone H3-K36 trimethylation [Evidence IMP] [PMID 17948059]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:0034402 - recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 18469135]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 19164765]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 11927560]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005770 - late endosome [Evidence IMP] [PMID 11872141]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 8163546]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 22748138]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI] [PMID 23612966]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8163546]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 22748138]; GO_process: GO:0036258 - multivesicular body assembly [Evidence IGI] [PMID 22748138]; GO_process: GO:0036010 - protein localization to endosome [Evidence IGI] [PMID 23264632]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8163546]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01868
Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 2999113]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IDA] [PMID 21321019]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IMP,ISA] [PMID 2999113]; GO_process: GO:0070159 - mitochondrial threonyl-tRNA aminoacylation [Evidence IDA] [PMID 21321019]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08329
Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12909721]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18482875]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12912927]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 17170004]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 19430531]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence NAS] [PMID 11779788]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 11779788]; GO_process: GO:0000723 - telomere maintenance [Evidence TAS] [PMID 13678589]
similar to AA sequence:KEGG_Orthology:K11313
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IDA] [PMID 11485989]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IMP] [PMID 9858534]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IDA] [PMID 12072450]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IDA] [PMID 12072450]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12370284]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13103
similar to AA sequence:KEGG_Orthology:K17782
Mitochondrial oxidoreductase; involved in mitochondrial intermembrane space import; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 15364952]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 15620710]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 15359280]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IDA] [PMID 23834247]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IMP] [PMID 22990235]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 22990235]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 15359280]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 15364952]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IPI] [PMID 15989955]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 17336303]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00949
Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004788 - thiamine diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004788 - thiamine diphosphokinase activity [Evidence IDA] [PMID 18652651]; GO_function: GO:0004788 - thiamine diphosphokinase activity [Evidence IDA,IMP] [PMID 8394343]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence IMP] [PMID 8394343]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence TAS] [PMID 9655908]
tRNA splicing endonuclease subunit SEN34
similar to AA sequence:KEGG_Orthology:K15323
similar to AA sequence:KEGG_Orthology:K01624
similar to AA sequence:KEGG_Orthology:K02930
Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00700
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003844 - 1,4-alpha-glucan branching enzyme activity [Evidence IEA,IEA]; GO_function: GO:0003844 - 1,4-alpha-glucan branching enzyme activity [Evidence IGI,IMP] [PMID 1729600]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0043169 - cation binding [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IMP] [PMID 1729600]
similar to AA sequence:KEGG_Orthology:K01679
Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11585823]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 11585823]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045239 - tricarboxylic acid cycle enzyme complex [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004333 - fumarate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004333 - fumarate hydratase activity [Evidence IDA] [PMID 3040736]; GO_function: GO:0016829 - lyase activity [Evidence IEA,IEA]; GO_process: GO:0006106 - fumarate metabolic process [Evidence IEA]; GO_process: GO:0006106 - fumarate metabolic process [Evidence IMP] [PMID 1587456]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 1587456]
similar to AA sequence:KEGG_Orthology:K14545
Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI,IMP] [PMID 9271380]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IGI,IMP] [PMID 9271380]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IDA,IMP] [PMID 16096273]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018027 - peptidyl-lysine dimethylation [Evidence IDA,IMP] [PMID 16096273]
similar to AA sequence:KEGG_Orthology:K15449
Iron-sulfur protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16162496]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
similar to AA sequence:KEGG_Orthology:K03843
Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IC] [PMID 16878994]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004378 - GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004378 - GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [Evidence IDA] [PMID 16878994]; GO_function: GO:0033164 - glycolipid 6-alpha-mannosyltransferase activity [Evidence IDA] [PMID 16878994]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IDA] [PMID 16878994]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11365
SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; relocalizes to the cytosol in response to hypoxia; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; GO_component: GO:0071819 - DUBm complex [Evidence IDA] [PMID 20395473]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0000124 - SAGA complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 17090597]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 18488019]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 20434206]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 15932941]; GO_function: GO:0005198 - structural molecule activity [Evidence IGI,IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 17090597]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 12052880]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 15932941]; GO_process: GO:0016578 - histone deubiquitination [Evidence IMP] [PMID 19226466]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 18488019]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 17090597]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 19226466]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
putative ATP-binding cassette family ATPase CAF16
similar to AA sequence:KEGG_Orthology:K12608
Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator; GO_component: GO:0030014 - CCR4-NOT complex [Evidence IDA] [PMID 11113136]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 10581358]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP,IPI] [PMID 11113136]
similar to AA sequence:KEGG_Orthology:K00227
C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 21737688]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000248 - C-5 sterol desaturase activity [Evidence IDA] [PMID 34600]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 1864507]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K10590
Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 10688918]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IBA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IMP] [PMID 22497224]; GO_process: GO:0006513 - protein monoubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0000209 - protein polyubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]
Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein; GO_component: GO:0051285 - cell cortex of cell tip [Evidence IDA] [PMID 23673619]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IGI,IPI] [PMID 8524314]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 8524314]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IGI,IPI] [PMID 8524314]
Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16204239]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0032217 - riboflavin transporter activity [Evidence IGI] [PMID 16204239]; GO_process: GO:0032218 - riboflavin transport [Evidence IGI] [PMID 16204239]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07179
similar to AA sequence:KEGG_Orthology:K15025
Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 17176761]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19254924]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15950597]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9802016]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence ISS] [PMID 8654575]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence IMP] [PMID 9802016]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IDA] [PMID 15950597]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030004 - cellular monovalent inorganic cation homeostasis [Evidence IMP] [PMID 9802016]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IMP] [PMID 16402204]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 16402204]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14556
Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05757
Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 15485833]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10377407]; GO_process: GO:0045010 - actin nucleation [Evidence IDA] [PMID 15485833]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01756
Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0070626 - (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate AMP-lyase (fumarate-forming) activity [Evidence IEA]; GO_function: GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [Evidence IMP] [PMID 5807803]; GO_function: GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [Evidence IMP] [PMID 7896125]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0044208 - 'de novo' AMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 5807803]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IGI] [PMID 7896125]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5807803]; GO_process: GO:0009152 - purine ribonucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15148
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18584
Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IEA]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 15657399]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IEA]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IMP] [PMID 16862144]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10377407]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 11248049]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
mitochondrial 54S ribosomal protein IMG2
similar to AA sequence:KEGG_Orthology:K17430
Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01634
Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 18487605]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 18487605]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008117 - sphinganine-1-phosphate aldolase activity [Evidence IEA]; GO_function: GO:0008117 - sphinganine-1-phosphate aldolase activity [Evidence IDA] [PMID 9334171]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 11278643]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 10329480]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IGI,IMP] [PMID 9334171]
hypothetical protein; potential Cdc28p substrate; overproduction confers resistance to methylmercury; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0071406 - cellular response to methylmercury [Evidence IGI,IMP] [PMID 15796894]
Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 10341420]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016722 - oxidoreductase activity, oxidizing metal ions [Evidence ISS] [PMID 10341420]; GO_function: GO:0016722 - oxidoreductase activity, oxidizing metal ions [Evidence IMP] [PMID 14534306]; GO_process: GO:0006875 - cellular metal ion homeostasis [Evidence IMP] [PMID 14534306]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18550
Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0050483 - IMP 5'-nucleotidase activity [Evidence IDA] [PMID 12735798]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006190 - inosine salvage [Evidence IMP] [PMID 12735798]; GO_process: GO:0071590 - nicotinamide riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0071592 - nicotinic acid riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA,IEA]
Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI,IMP] [PMID 16219777]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IGI] [PMID 14764870]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA,IEA]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 19730685]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IMP] [PMID 18321795]; GO_process: GO:0045132 - meiotic chromosome segregation [Evidence IMP] [PMID 11470404]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 17483413]; GO_process: GO:0008156 - negative regulation of DNA replication [Evidence IEA]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16103218]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16418273]; GO_process: GO:0048478 - replication fork protection [Evidence IEA]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 16418273]
carboxylesterase-mitochondrial 37S ribosomal protein YmS2
similar to AA sequence:KEGG_Orthology:K13617
Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_function: GO:0052689 - carboxylic ester hydrolase activity [Evidence IEA]; GO_function: GO:0052689 - carboxylic ester hydrolase activity [Evidence IMP] [PMID 11060018]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0006464 - cellular protein modification process [Evidence IGI] [PMID 11060018]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006482 - protein demethylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01950
Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12898714]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12898714]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence ISS] [PMID 11380987]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence IDA,IMP] [PMID 12771147]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence IDA,IMP] [PMID 12898714]; GO_function: GO:0004359 - glutaminase activity [Evidence IDA,IMP] [PMID 12771147]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA,IMP] [PMID 12771147]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA,IMP] [PMID 12898714]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00931
Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence IEA,IEA]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence IDA] [PMID 12513997]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence ISS] [PMID 1350780]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence IGI,IMP] [PMID 2824433]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IDA] [PMID 12513997]
similar to AA sequence:KEGG_Orthology:K14169
Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18664566]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 14551258]; GO_process: GO:0032447 - protein urmylation [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 14551258]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IEA,IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 17018299]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18664566]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18755837]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA,IEA]
Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II; GO_component: GO:0097255 - R2TP complex [Evidence IDA] [PMID 15766533]; GO_component: GO:0097255 - R2TP complex [Evidence IPI] [PMID 18268103]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005732 - small nucleolar ribonucleoprotein complex [Evidence IPI] [PMID 15670595]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IGI,IMP,IPI] [PMID 15766533]; GO_process: GO:0006364 - rRNA processing [Evidence IGI,IMP,IPI] [PMID 15670595]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]
similar to AA sequence:KEGG_Orthology:K18064
similar to AA sequence:KEGG_Orthology:K12736
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IPI] [PMID 15643056]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643056]; GO_function: GO:0016018 - cyclosporin A binding [Evidence IMP] [PMID 7515500]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 2687115]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 15643056]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 11641409]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 12242280]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045836 - positive regulation of meiosis [Evidence IGI,IMP] [PMID 15643056]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07359
similar to AA sequence:KEGG_Orthology:K00026
Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9774331]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10777592]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IMP] [PMID 10777592]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IDA] [PMID 1898005]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016615 - malate dehydrogenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3312168]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 3312168]
similar to AA sequence:KEGG_Orthology:K17686
Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0012510 - trans-Golgi network transport vesicle membrane [Evidence IDA] [PMID 9325307]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IDA] [PMID 15078884]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IMP] [PMID 7708696]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 17961510]; GO_function: GO:0043682 - copper-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 7708696]; GO_process: GO:0060003 - copper ion export [Evidence IMP] [PMID 7708696]; GO_process: GO:0006825 - copper ion transport [Evidence IEA,IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7708696]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08332
Phosphorylated and palmitoylated vacuolar membrane protein; interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions; GO_component: GO:0071563 - Myo2p-Vac17p-Vac8p transport complex [Evidence IDA,IPI] [PMID 12529432]; GO_component: GO:0071563 - Myo2p-Vac17p-Vac8p transport complex [Evidence IPI] [PMID 12594460]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16301533]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9490720]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9664035]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9739084]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0071561 - nucleus-vacuole junction [Evidence IDA,IPI] [PMID 10888680]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IMP,IPI] [PMID 10888680]; GO_function: GO:0043495 - protein anchor [Evidence IMP,IPI] [PMID 12594460]; GO_process: GO:0071255 - CVT vesicle assembly [Evidence IMP] [PMID 10837477]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 15901835]; GO_process: GO:0071562 - nucleus-vacuole junction assembly [Evidence IMP] [PMID 10888680]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 12529432]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 11441010]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 16301533]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 16301533]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 8885233]
similar to AA sequence:KEGG_Orthology:K12615
Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23706738]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 15020463]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23706738]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 24492965]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 17984320]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IGI,IMP] [PMID 18981231]; GO_process: GO:0031087 - deadenylation-independent decapping of nuclear-transcribed mRNA [Evidence IMP] [PMID 15225544]; GO_process: GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP] [PMID 24492965]
similar to AA sequence:KEGG_Orthology:K02216
similar to AA sequence:KEGG_Orthology:K00166
similar to AA sequence:KEGG_Orthology:K15728
Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16467296]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 16467296]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IDA] [PMID 20876142]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IDA] [PMID 22121197]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IDA,IMP] [PMID 16467296]; GO_function: GO:0044212 - transcription regulatory region DNA binding [Evidence IDA] [PMID 15889145]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8437575]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0034389 - lipid particle organization [Evidence IMP] [PMID 21422231]; GO_process: GO:0034389 - lipid particle organization [Evidence IGI] [PMID 21829381]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 16467296]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 17971454]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 8437575]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0019432 - triglyceride biosynthetic process [Evidence IGI,IMP] [PMID 24196957]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 22121197]
similar to AA sequence:KEGG_Orthology:K13217
U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 8196608]; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IGI] [PMID 8196608]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0030627 - pre-mRNA 5'-splice site binding [Evidence IGI] [PMID 8196608]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000395 - mRNA 5'-splice site recognition [Evidence IGI] [PMID 8196608]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17541
Putative kinase; suppressor of GTPase mutant, similar to bovine rhodopsin kinase; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]
H(+)-transporting V1 sector ATPase subunit H
similar to AA sequence:KEGG_Orthology:K02144
Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
similar to AA sequence:KEGG_Orthology:K03305
Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 8264579]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0042937 - tripeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_process: GO:0042938 - dipeptide transport [Evidence IDA] [PMID 16096264]; GO_process: GO:0006857 - oligopeptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IMP] [PMID 8264579]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IDA] [PMID 16096264]
similar to AA sequence:KEGG_Orthology:K14817
Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16871394]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IPI] [PMID 11309412]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16871394]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16871394]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16871394]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 11309412]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15634
Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IDA] [PMID 19753119]; GO_function: GO:0016791 - phosphatase activity [Evidence IDA] [PMID 20427268]; GO_process: GO:0016311 - dephosphorylation [Evidence IDA] [PMID 19753119]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10839
Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000111 - nucleotide-excision repair factor 2 complex [Evidence IDA] [PMID 7768886]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 15117949]; GO_component: GO:0000502 - proteasome complex [Evidence IMP] [PMID 15242647]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9813069]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9837874]; GO_function: GO:0000224 - peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [Evidence IDA] [PMID 20016784]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 15121879]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 11323716]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15167887]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 19889839]; GO_process: GO:0006517 - protein deglycosylation [Evidence IDA] [PMID 20016784]
Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 23118189]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15430
Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15899842]; GO_component: GO:0043528 - tRNA (m2G10) methyltransferase complex [Evidence IPI] [PMID 15899842]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 15899842]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 12872006]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 15899842]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004809 - tRNA (guanine-N2-)-methyltransferase activity [Evidence IDA,IMP] [PMID 15899842]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 15899842]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14411
Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9334319]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15572678]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9334319]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9334319]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15703440]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 17684230]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 9334319]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07238
Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 10856230]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IMP] [PMID 10856230]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 10856230]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 10856230]
similar to AA sequence:KEGG_Orthology:K12346
Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8643535]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IDA] [PMID 10574989]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015295 - solute:proton symporter activity [Evidence IDA] [PMID 10574989]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015691 - cadmium ion transport [Evidence IGI] [PMID 9115231]; GO_process: GO:0006876 - cellular cadmium ion homeostasis [Evidence IGI] [PMID 9115231]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI] [PMID 9115231]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 8643535]; GO_process: GO:0006825 - copper ion transport [Evidence IGI] [PMID 9115231]; GO_process: GO:0006826 - iron ion transport [Evidence IGI] [PMID 10930410]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 8643535]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Nucleosome assembly factor; involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11404324]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0042393 - histone binding [Evidence IMP] [PMID 15840725]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IDA] [PMID 11412995]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 15840725]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 15840725]; GO_process: GO:0033523 - histone H2B ubiquitination [Evidence IMP] [PMID 24824343]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 16627621]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 17679090]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IMP] [PMID 16678113]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IDA,IMP] [PMID 17272722]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IMP] [PMID 17679090]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IMP,IPI] [PMID 17690098]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IDA,IGI,IMP] [PMID 18458063]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 22308335]; GO_process: GO:0043618 - regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 19620280]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01115
Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 10848624]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21954159]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 9693364]; GO_function: GO:0070290 - N-acylphosphatidylethanolamine-specific phospholipase D activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0004630 - phospholipase D activity [Evidence IEA]; GO_function: GO:0004630 - phospholipase D activity [Evidence IDA] [PMID 11514437]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IMP] [PMID 16554438]; GO_process: GO:0000753 - cell morphogenesis involved in conjugation with cellular fusion [Evidence IMP] [PMID 12702348]; GO_process: GO:0000753 - cell morphogenesis involved in conjugation with cellular fusion [Evidence IGI] [PMID 18036176]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 10848624]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 11514437]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IDA,IMP] [PMID 8576189]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; PPZ1 has a paralog, PPZ2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 16166647]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8824289]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004724 - magnesium-dependent protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 7615085]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 21237705]; GO_process: GO:0006883 - cellular sodium ion homeostasis [Evidence IGI,IMP] [PMID 7768897]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 21237705]
similar to AA sequence:KEGG_Orthology:K06628
DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8901577]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 12019222]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 15494305]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9554851]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA,IMP] [PMID 23382391]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 2044962]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16980387]
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17450
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00276
Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 24868093]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 18034159]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 18034159]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0034084 - steryl deacetylase activity [Evidence IDA,IMP] [PMID 18034159]; GO_process: GO:0009636 - response to toxic substance [Evidence IMP] [PMID 18034159]; GO_process: GO:0034210 - sterol deacetylation [Evidence IMP] [PMID 18034159]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 18034159]
similar to S.kluyveri pyd3 (AAK60518) beta-alanine synthase involved in pyrimidine catabolism; allele of CaO19.8949
Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11943786]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA,IGI,IMP,IPI,ISS] [PMID 11943786]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043619 - regulation of transcription from RNA polymerase II promoter in response to oxidative stress [Evidence IMP] [PMID 16914749]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0009410 - response to xenobiotic stimulus [Evidence IMP] [PMID 11943786]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IDA] [PMID 11943786]
similar to AA sequence:KEGG_Orthology:K10437
similar to AA sequence:KEGG_Orthology:K09554
Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9242486]; GO_process: GO:0000161 - MAPK cascade involved in osmosensory signaling pathway [Evidence IMP,IPI] [PMID 17220467]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 17242065]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 7753858]; GO_process: GO:0032872 - regulation of stress-activated MAPK cascade [Evidence IMP,IPI] [PMID 17220467]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IGI,IMP] [PMID 9060463]
similar to AA sequence:KEGG_Orthology:K01880
Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 10874035]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10874035]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004820 - glycine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004820 - glycine-tRNA ligase activity [Evidence IMP,ISS] [PMID 10874035]; GO_function: GO:0004820 - glycine-tRNA ligase activity [Evidence IDA] [PMID 21877692]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 10224248]; GO_process: GO:0006426 - glycyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006426 - glycyl-tRNA aminoacylation [Evidence IMP,ISS] [PMID 10874035]; GO_process: GO:0070150 - mitochondrial glycyl-tRNA aminoacylation [Evidence IMP] [PMID 10874035]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IGI,ISS] [PMID 8449403]; GO_function: GO:0030619 - U1 snRNA binding [Evidence IPI] [PMID 8849781]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0017069 - snRNA binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 8449403]
similar to AA sequence:KEGG_Orthology:K09528
similar to AA sequence:KEGG_Orthology:K04794
One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 12475929]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IGI] [PMID 12475929]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IDA] [PMID 12799450]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0032435 - negative regulation of proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 17082762]
similar to AA sequence:KEGG_Orthology:K09831
C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0000249 - C-22 sterol desaturase activity [Evidence IDA] [PMID 8543054]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8543054]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8635732]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000137 - Golgi cis cisterna [Evidence IDA] [PMID 9430634]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 9434768]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA,IMP] [PMID 9430634]
similar to AA sequence:KEGG_Orthology:K11887
Assembly chaperone for the 19S proteasome regulatory particle base; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19412159]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17499717]
H(+)-transporting V1 sector ATPase subunit B
similar to AA sequence:KEGG_Orthology:K02147
Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 18048916]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0033180 - proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IDA] [PMID 2478556]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IDA] [PMID 2857169]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 2141385]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 10991947]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:1902906 - proteasome storage granule assembly [Evidence IMP] [PMID 23690178]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 2141385]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 18048916]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 2141385]
similar to AA sequence:KEGG_Orthology:K07208
Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IGI] [PMID 10753927]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 10753927]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IGI,IMP] [PMID 10753927]; GO_process: GO:0015819 - lysine transport [Evidence IMP] [PMID 10753927]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IMP] [PMID 17101785]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01067
Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11746603]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12606555]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008775 - acetate CoA-transferase activity [Evidence IDA] [PMID 19298859]; GO_function: GO:0003986 - acetyl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003986 - acetyl-CoA hydrolase activity [Evidence IDA] [PMID 12606555]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006083 - acetate metabolic process [Evidence IMP] [PMID 8841387]; GO_process: GO:0006084 - acetyl-CoA metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00876
Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004849 - uridine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004849 - uridine kinase activity [Evidence IMP] [PMID 10501935]; GO_process: GO:0044211 - CTP salvage [Evidence IEA]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IGI,IMP] [PMID 11872485]
similar to AA sequence:KEGG_Orthology:K14430
Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 17804816]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015169 - glycerol-3-phosphate transmembrane transporter activity [Evidence IGI,IMP] [PMID 20133652]; GO_function: GO:0005315 - inorganic phosphate transmembrane transporter activity [Evidence IGI] [PMID 11779791]; GO_function: GO:0005315 - inorganic phosphate transmembrane transporter activity [Evidence IMP] [PMID 12581367]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015794 - glycerol-3-phosphate transport [Evidence IGI,IMP] [PMID 20133652]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0006817 - phosphate ion transport [Evidence IGI] [PMID 11779791]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IMP] [PMID 17804816]; GO_process: GO:2000185 - regulation of phosphate transmembrane transport [Evidence IGI] [PMID 12821119]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16055
Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IGI,IMP,IPI] [PMID 9837904]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003825 - alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [Evidence IMP,ISS] [PMID 9837904]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP,ISS] [PMID 9837904]; GO_function: GO:0004805 - trehalose-phosphatase activity [Evidence IGI] [PMID 9837904]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IGI,IMP,IPI] [PMID 9837904]
C-terminal domain kinase I (CTDK-I) gamma subunit (predicted)
similar to AA sequence:KEGG_Orthology:K15565
similar to AA sequence:KEGG_Orthology:K03236
Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 16380131]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003725 - double-stranded RNA binding [Evidence IDA] [PMID 17673174]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 17434125]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 10982835]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IMP] [PMID 16461768]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IGI] [PMID 17242201]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 12514125]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 15664195]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 15838098]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 17434125]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15078
Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p; GO_component: GO:0033557 - Slx1-Slx4 complex [Evidence IEA,IEA]; GO_component: GO:0033557 - Slx1-Slx4 complex [Evidence IPI] [PMID 12832395]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12832395]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IEA,IEA]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IDA] [PMID 12832395]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IGI] [PMID 12832395]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05546
Glucosidase II catalytic subunit; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence ISS] [PMID 8910335]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 16373354]; GO_component: GO:0017177 - glucosidase II complex [Evidence IPI] [PMID 16373354]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0033919 - glucan 1,3-alpha-glucosidase activity [Evidence IEA]; GO_function: GO:0033919 - glucan 1,3-alpha-glucosidase activity [Evidence IMP] [PMID 16373354]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 9430631]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04708
3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0047560 - 3-dehydrosphinganine reductase activity [Evidence IEA]; GO_function: GO:0047560 - 3-dehydrosphinganine reductase activity [Evidence IDA] [PMID 9804843]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006666 - 3-keto-sphinganine metabolic process [Evidence IDA] [PMID 9804843]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IDA,IMP,ISS] [PMID 9804843]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
mitochondrial 54S ribosomal protein YmL8
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 2183197]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
eukaryotic translation initiation factor 3 subunit 6
similar to AA sequence:KEGG_Orthology:K03250
similar to AA sequence:KEGG_Orthology:K10413
Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 16580990]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15642746]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005868 - cytoplasmic dynein complex [Evidence IPI] [PMID 9658168]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0030286 - dynein complex [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16580990]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IDA] [PMID 16873064]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0040001 - establishment of mitotic spindle localization [Evidence IMP] [PMID 21633107]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IGI,IMP] [PMID 9201714]
similar to AA sequence:KEGG_Orthology:K01640
SCF ubiquitin ligase complex subunit SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 11283612]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IMP,IPI,ISS] [PMID 17517885]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 19882662]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP,ISS] [PMID 17517885]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16677311]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP,ISS] [PMID 17517885]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17637
Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11595741]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11595741]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11595741]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 15583030]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15583030]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 15583030]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0008474 - palmitoyl-(protein) hydrolase activity [Evidence IDA,IMP,ISS] [PMID 12080046]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0035601 - protein deacylation [Evidence IDA,IMP] [PMID 12080046]
similar to AA sequence:KEGG_Orthology:K15326
Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p, Sen15p, Sen34p, and Sen54p; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA,IMP] [PMID 12925762]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000214 - tRNA-intron endonuclease complex [Evidence IDA] [PMID 9200603]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IDA] [PMID 9200603]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0000379 - tRNA-type intron splice site recognition and cleavage [Evidence IDA] [PMID 9200603]
Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12668726]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12668726]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15935782]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 17446860]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IGI,IMP] [PMID 23444383]; GO_process: GO:0016579 - protein deubiquitination [Evidence IGI,IPI] [PMID 15326198]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 14523026]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007584 - response to nutrient [Evidence IMP] [PMID 8649366]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12062418]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 12668726]
Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 12686616]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12686616]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 18508925]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03872
Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IPI] [PMID 16675952]; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IMP] [PMID 17296727]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0070449 - elongin complex [Evidence IPI] [PMID 10430890]; GO_component: GO:0070449 - elongin complex [Evidence IPI] [PMID 10753924]; GO_component: GO:0000113 - nucleotide-excision repair factor 4 complex [Evidence IDA] [PMID 15226437]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 18817898]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 16675952]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16705154]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11551
Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000942 - condensed nuclear chromosome outer kinetochore [Evidence IDA] [PMID 12589047]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 12589047]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 12642611]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0034508 - centromere complex assembly [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8243998]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 9339342]; GO_process: GO:0034089 - establishment of meiotic sister chromatid cohesion [Evidence IMP] [PMID 19730685]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 19730685]; GO_process: GO:0051382 - kinetochore assembly [Evidence IMP] [PMID 12642611]; GO_process: GO:0034090 - maintenance of meiotic sister chromatid cohesion [Evidence IMP] [PMID 14752166]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0071459 - protein localization to chromosome, centromeric region [Evidence IMP] [PMID 16357219]; GO_process: GO:0071173 - spindle assembly checkpoint [Evidence IMP] [PMID 22426531]
similar to AA sequence:KEGG_Orthology:K14573
Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9312154]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8039505]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 8039505]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15447
tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016300 - tRNA (uracil) methyltransferase activity [Evidence IDA,IMP] [PMID 18025252]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 18025252]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
cyclin-dependent serine/threonine-protein kinase PHO85
similar to AA sequence:KEGG_Orthology:K06655
Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 16611745]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 7973730]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 7973731]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 8108735]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 9584169]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9853758]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 12407105]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 19823668]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 7973730]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 7973731]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 8108735]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 9584169]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 16964260]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 12077337]; GO_process: GO:0050849 - negative regulation of calcium-mediated signaling [Evidence IGI] [PMID 16455487]; GO_process: GO:0045719 - negative regulation of glycogen biosynthetic process [Evidence IMP] [PMID 9584169]; GO_process: GO:0016242 - negative regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0045936 - negative regulation of phosphate metabolic process [Evidence IGI] [PMID 3915785]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IGI] [PMID 12101234]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 16455487]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 3915785]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 19823668]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 7973731]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8108735]; GO_process: GO:0032878 - regulation of establishment or maintenance of cell polarity [Evidence IGI] [PMID 17853895]; GO_process: GO:0032880 - regulation of protein localization [Evidence IDA] [PMID 8539622]; GO_process: GO:0031647 - regulation of protein stability [Evidence IMP] [PMID 16508019]; GO_process: GO:0031647 - regulation of protein stability [Evidence IGI] [PMID 16611745]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 15738404]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 19823668]
Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11595741]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9491896]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11595741]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9491896]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11595741]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9491896]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9491896]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IDA] [PMID 11283608]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IPI] [PMID 11595741]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 18195105]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 12960429]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IGI,IMP] [PMID 15583030]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15583030]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 17717527]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 18946089]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 12913108]; GO_process: GO:0006887 - exocytosis [Evidence IDA] [PMID 15772160]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17717527]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
similar to AA sequence:KEGG_Orthology:K03124
Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15888545]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA,IPI] [PMID 7935466]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IEA]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA,IPI] [PMID 15888545]; GO_function: GO:0001129 - TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [Evidence IDA,IMP] [PMID 10464320]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IDA,IMP] [PMID 10464320]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA,IMP] [PMID 10464320]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 9887099]; GO_process: GO:2000679 - positive regulation of transcription regulatory region DNA binding [Evidence IDA] [PMID 8132551]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001113 - transcriptional open complex formation at RNA polymerase II promoter [Evidence IMP] [PMID 19820686]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 19820686]
similar to AA sequence:KEGG_Orthology:K14538
GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16803892]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IGI] [PMID 16803892]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 16803892]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16803892]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12089522]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 11583615]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
ATP-binding cassette multidrug transporter PDR5
similar to AA sequence:KEGG_Orthology:K08711
Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8810273]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence IDA] [PMID 21207971]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015893 - drug transport [Evidence TAS] [PMID 11421285]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]; GO_process: GO:0046898 - response to cycloheximide [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence TAS] [PMID 11421285]; GO_process: GO:0042493 - response to drug [Evidence IMP] [PMID 17881724]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IDA] [PMID 8127709]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8127709]
similar to AA sequence:KEGG_Orthology:K06672
similar to AA sequence:KEGG_Orthology:K03120
TATA-binding protein; general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 8702872]; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 9632758]; GO_component: GO:0000500 - RNA polymerase I upstream activating factor complex [Evidence IDA] [PMID 9632758]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9818719]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_component: GO:0000126 - transcription factor TFIIIB complex [Evidence IDA] [PMID 1423590]; GO_component: GO:0000126 - transcription factor TFIIIB complex [Evidence IDA] [PMID 1458536]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 1736286]; GO_function: GO:0001179 - RNA polymerase I transcription factor binding [Evidence IDA,IPI] [PMID 8895657]; GO_function: GO:0001186 - RNA polymerase I transcription factor recruiting transcription factor activity [Evidence IDA,IPI] [PMID 8895657]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding [Evidence IDA] [PMID 2677740]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0001016 - RNA polymerase III regulatory region DNA binding [Evidence IDA] [PMID 8662956]; GO_function: GO:0001026 - TFIIIB-type transcription factor activity [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 19098311]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IDA] [PMID 1480467]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 1586947]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0070893 - transposon integration [Evidence IDA] [PMID 10882723]
similar to AA sequence:KEGG_Orthology:K18339
similar to AA sequence:KEGG_Orthology:K13953
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3550419]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3550419]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 3546317]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006113 - fermentation [Evidence ISS] [PMID 3550419]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
L-aminoadipate-semialdehyde dehydrogenase
similar to AA sequence:KEGG_Orthology:K00143
Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 3928261]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IDA] [PMID 10320345]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IMP] [PMID 3023949]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IMP] [PMID 4401608]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0031177 - phosphopantetheine binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IDA] [PMID 10320345]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 3023949]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 4401608]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12580
Subunit of CCR4-NOT global transcriptional regulator; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 10490603]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11889048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16926149]; GO_process: GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA] [PMID 11889048]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16926149]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10490603]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00615
Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 2843500]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IEA,IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IMP,ISS] [PMID 8226984]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 8299150]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence TAS] [PMID 8534086]
similar to AA sequence:KEGG_Orthology:K15075
Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 22678361]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 22678362]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03097
Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 8226802]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0007535 - donor selection [Evidence IGI] [PMID 22496671]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 16607517]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
similar to AA sequence:KEGG_Orthology:K11269
Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16962805]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 20980819]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 17636314]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 21347277]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11287619]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11389843]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 17483413]
Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA,ISS] [PMID 12186856]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17135291]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 17135291]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16107716]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 12186856]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 17135291]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 17135291]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 17135291]; GO_process: GO:0034497 - protein localization to pre-autophagosomal structure [Evidence IMP] [PMID 17135291]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IMP] [PMID 12186856]
similar to AA sequence:KEGG_Orthology:K09548
similar to AA sequence:KEGG_Orthology:K07556
Assembly factor for the F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for the assembly of alpha and beta subunits into the F1 sector of the mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1826907]; GO_function: GO:0019904 - protein domain specific binding [Evidence IPI] [PMID 10747017]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IPI] [PMID 10747017]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 2142305]; GO_process: GO:0043461 - proton-transporting ATP synthase complex assembly [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07375
Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005874 - microtubule [Evidence IEA,IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0043234 - protein complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_component: GO:0045298 - tubulin complex [Evidence IDA,IPI] [PMID 9488492]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IC] [PMID 9488492]; GO_process: GO:0051258 - protein polymerization [Evidence IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01958
Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 196563]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2665820]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004736 - pyruvate carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004736 - pyruvate carboxylase activity [Evidence IMP] [PMID 2039506]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 8185321]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12874
ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14763985]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005844 - polysome [Evidence TAS] [PMID 10098411]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence TAS] [PMID 10098411]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 23801788]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 23390378]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 16157874]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 16777600]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 16285926]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA,IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence TAS] [PMID 10098411]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP,IPI] [PMID 18676617]; GO_process: GO:0006449 - regulation of translational termination [Evidence TAS] [PMID 10098411]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 15388879]
H/ACA snoRNP pseudouridylase subunit GAR1
similar to AA sequence:KEGG_Orthology:K11128
Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IEA]; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IPI] [PMID 2898766]; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IPI] [PMID 9843512]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 1531632]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005732 - small nucleolar ribonucleoprotein complex [Evidence IPI] [PMID 1531632]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0034513 - box H/ACA snoRNA binding [Evidence IPI] [PMID 9556561]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IDA] [PMID 15962000]
similar to AA sequence:KEGG_Orthology:K12472
Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10954428]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11452010]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11452010]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16563434]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 10954428]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 16582425]
similar to AA sequence:KEGG_Orthology:K15296
Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8636207]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 1601878]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 10387016]; GO_function: GO:0005483 - soluble NSF attachment protein activity [Evidence IPI] [PMID 10387016]; GO_function: GO:0005483 - soluble NSF attachment protein activity [Evidence IDA] [PMID 11994317]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 18650938]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 9425154]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 11694599]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 8670830]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 9685264]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IDA] [PMID 1601878]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
similar to AA sequence:KEGG_Orthology:K01955
Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; GO_component: GO:0005951 - carbamoyl-phosphate synthase complex [Evidence IDA] [PMID 206535]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IMP] [PMID 6358221]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 8626695]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 8626695]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11361
Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; GO_component: GO:0000124 - SAGA complex [Evidence IEA]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IGI,IMP,IPI] [PMID 8649430]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 10652329]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12878
similar to AA sequence:KEGG_Orthology:K11187
similar to AA sequence:KEGG_Orthology:K12612
Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23706738]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA,IMP] [PMID 12730603]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23509072]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23706738]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16341225]; GO_function: GO:0050072 - m7G(5')pppN diphosphatase activity [Evidence IDA] [PMID 16341225]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 11139489]; GO_process: GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA [Evidence IDA] [PMID 11139489]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11968
Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP] [PMID 9430719]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 9430719]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 9430719]; GO_process: GO:0015693 - magnesium ion transport [Evidence IDA] [PMID 12167543]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 9430719]; GO_process: GO:0006810 - transport [Evidence IEA]
Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21273246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21273246]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 21273246]
similar to AA sequence:KEGG_Orthology:K05349
Mitochondrial ribosomal protein of the small subunit
Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IMP] [PMID 9343395]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005245 - voltage-gated calcium channel activity [Evidence ISS] [PMID 9343395]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA] [PMID 10958666]; GO_process: GO:0006816 - calcium ion transport [Evidence IMP] [PMID 9343395]; GO_process: GO:0006811 - ion transport [Evidence IEA,IEA]; GO_process: GO:0034765 - regulation of ion transmembrane transport [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17
similar to AA sequence:KEGG_Orthology:K00602
Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10877846]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003937 - IMP cyclohydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003937 - IMP cyclohydrolase activity [Evidence IDA] [PMID 10877846]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity [Evidence IDA] [PMID 10877846]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IDA,IMP] [PMID 10877846]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IDA,IMP] [PMID 10877846]
similar to AA sequence:KEGG_Orthology:K02877
Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 6814480]; GO_process: GO:0006412 - translation [Evidence IEA]
hypothetical protein; similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17034789]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17034789]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003934 - GTP cyclohydrolase I activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0035998 - 7,8-dihydroneopterin 3'-triphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K11137
Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000784 - nuclear chromosome, telomeric region [Evidence IDA] [PMID 9490802]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 10525964]; GO_process: GO:0034502 - protein localization to chromosome [Evidence IMP] [PMID 18334620]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 3513174]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 8649421]
bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17
similar to AA sequence:KEGG_Orthology:K17069
O-acetyl homoserine-O-acetyl serine sulfhydrylase; required for Methionine and cysteine biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003961 - O-acetylhomoserine aminocarboxypropyltransferase activity [Evidence IEA]; GO_function: GO:0003961 - O-acetylhomoserine aminocarboxypropyltransferase activity [Evidence TAS] [PMID 3299001]; GO_function: GO:0003961 - O-acetylhomoserine aminocarboxypropyltransferase activity [Evidence IDA] [PMID 7765825]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IEA]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IDA] [PMID 7765825]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0071266 - 'de novo' L-methionine biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence TAS] [PMID 15042590]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006555 - methionine metabolic process [Evidence IMP] [PMID 1101032]
hypothetical protein with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Actin-binding protein of the cortical actin cytoskeleton; important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; inhibits barbed-end actin filament elongation; phosphorylation within its Proline-Rich Regio, mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences; mammalian homologue of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa); GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3060468]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8163554]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11950888]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 3060468]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 18177206]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 2405279]; GO_process: GO:0051016 - barbed-end actin filament capping [Evidence IMP] [PMID 23333351]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 11668184]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 15798181]
similar to AA sequence:KEGG_Orthology:K02941
Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19797078]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 22096102]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19797079]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0070180 - large ribosomal subunit rRNA binding [Evidence IDA] [PMID 16164560]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 22096102]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 8195220]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 8195220]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA]
hypothetical protein; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
cyclin-dependent serine/threonine-protein kinase CDC28
similar to AA sequence:KEGG_Orthology:K04563
Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1 (CLNs), S and G2/M (CLBs) phase cyclins, which provide substrate specificity; regulates cell cycle and basal transcription, chromosome duplication and segregation, lipid biosynthesis, membrane trafficking, polarized growth, and morphogenesis; abundance increases in DNA replication stress; transcript induction in osmostress involves antisense RNA; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 15256500]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12554645]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IDA] [PMID 1849458]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IDA] [PMID 2142620]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 3312233]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17560371]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14685274]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12554645]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 22689984]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 2142620]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 20855529]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 22689984]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 23314252]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 24319056]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IMP] [PMID 22689984]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 20855529]; GO_process: GO:0000706 - meiotic DNA double-strand break processing [Evidence IGI] [PMID 20150422]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:2001033 - negative regulation of double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 19699692]; GO_process: GO:0051447 - negative regulation of meiotic cell cycle [Evidence IMP] [PMID 12081645]; GO_process: GO:0045930 - negative regulation of mitotic cell cycle [Evidence IDA] [PMID 10074450]; GO_process: GO:0045875 - negative regulation of sister chromatid cohesion [Evidence IMP] [PMID 21549314]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IMP] [PMID 12081645]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IDA,IMP] [PMID 14993267]; GO_process: GO:0018105 - peptidyl-serine phosphorylation [Evidence IDA] [PMID 23314252]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 22689984]; GO_process: GO:0051446 - positive regulation of meiotic cell cycle [Evidence IDA,IMP] [PMID 16814718]; GO_process: GO:0051446 - positive regulation of meiotic cell cycle [Evidence IMP] [PMID 2680756]; GO_process: GO:0045931 - positive regulation of mitotic cell cycle [Evidence IMP] [PMID 2165600]; GO_process: GO:0045931 - positive regulation of mitotic cell cycle [Evidence IMP] [PMID 7002718]; GO_process: GO:0010571 - positive regulation of nuclear cell cycle DNA replication [Evidence IMP] [PMID 12783856]; GO_process: GO:0010571 - positive regulation of nuclear cell cycle DNA replication [Evidence IDA,IMP] [PMID 14747467]; GO_process: GO:0010571 - positive regulation of nuclear cell cycle DNA replication [Evidence IMP] [PMID 4580573]; GO_process: GO:0010696 - positive regulation of spindle pole body separation [Evidence IGI,IMP] [PMID 16688214]; GO_process: GO:0010696 - positive regulation of spindle pole body separation [Evidence IMP] [PMID 8887667]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22689984]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA,IGI] [PMID 1652372]; GO_process: GO:0010898 - positive regulation of triglyceride catabolic process [Evidence IGI,IMP] [PMID 19150427]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0010568 - regulation of budding cell apical bud growth [Evidence IGI,IMP] [PMID 17417630]; GO_process: GO:0010569 - regulation of double-strand break repair via homologous recombination [Evidence IMP] [PMID 15496928]; GO_process: GO:0010570 - regulation of filamentous growth [Evidence IMP] [PMID 9891070]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 19188495]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 20702586]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 20825495]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 22767578]
similar to AA sequence:KEGG_Orthology:K12609
hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
ribonucleotide-diphosphate reductase subunit RNR2
similar to AA sequence:KEGG_Orthology:K10808
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12732713]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9315670]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12732713]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IDA] [PMID 10716984]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10535923]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10716984]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0009186 - deoxyribonucleoside diphosphate metabolic process [Evidence IEA]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 10535923]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 5459124]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K06648
similar to AA sequence:KEGG_Orthology:K12199
Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 16505166]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IDA] [PMID 14701806]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA,IMP] [PMID 16505166]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 16601096]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP,IPI] [PMID 12953057]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 16505166]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0032461 - positive regulation of protein oligomerization [Evidence IDA] [PMID 16505166]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
translation initiation factor eIF2 subunit alpha
similar to AA sequence:KEGG_Orthology:K03237
Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IEA]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IMP,ISS] [PMID 2649894]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence TAS] [PMID 9841679]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence TAS] [PMID 9841679]
similar to AA sequence:KEGG_Orthology:K06990
hypothetical protein; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22412880]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22412880]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IDA] [PMID 10564262]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0030139 - endocytic vesicle [Evidence IDA] [PMID 22190733]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IC] [PMID 22190733]
similar to AA sequence:KEGG_Orthology:K06877
3'-5' DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; acts with Rad4p in nucleotide-excision repair; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome (RTS); GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 23026052]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IDA] [PMID 23026052]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 23026052]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI,IPI] [PMID 24682993]; GO_process: GO:0006950 - response to stress [Evidence IEA]
mitogen-activated protein kinase kinase kinase SSK1
similar to AA sequence:KEGG_Orthology:K11233
Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14665464]; GO_function: GO:0031435 - mitogen-activated protein kinase kinase kinase binding [Evidence IPI] [PMID 9482735]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IMP] [PMID 8183345]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 18573873]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IDA,IMP] [PMID 9482735]; GO_process: GO:0000167 - activation of MAPKKK activity involved in osmosensory signaling pathway [Evidence IMP] [PMID 18573873]; GO_process: GO:0000167 - activation of MAPKKK activity involved in osmosensory signaling pathway [Evidence IGI] [PMID 9482735]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IMP] [PMID 19633059]; GO_process: GO:0031954 - positive regulation of protein autophosphorylation [Evidence IDA] [PMID 9482735]
bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 10710415]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 9832522]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06689
Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 10848595]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 11788821]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA,IMP] [PMID 21357418]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 2154373]; GO_process: GO:0034605 - cellular response to heat [Evidence IDA] [PMID 2154373]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA] [PMID 8391479]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 2154373]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 16926149]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 11788821]
similar to AA sequence:KEGG_Orthology:K10746
similar to AA sequence:KEGG_Orthology:K14007
Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 11086000]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 12426382]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence ISS] [PMID 12941277]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 12426382]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA,IMP] [PMID 12941277]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
Molybdopterin-converting factor subunit 2
similar to AA sequence:KEGG_Orthology:K03635
Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9499403]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9499403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 14676199]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IMP] [PMID 24452287]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IPI] [PMID 14769921]
similar to AA sequence:KEGG_Orthology:K11364
Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IMP,IPI] [PMID 21734642]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IMP] [PMID 21685874]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 21685874]; GO_process: GO:0034629 - cellular protein complex localization [Evidence IMP] [PMID 21685874]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 22224423]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0070868 - heterochromatin organization involved in chromatin silencing [Evidence IMP] [PMID 24307402]; GO_process: GO:0044154 - histone H3-K14 acetylation [Evidence IMP] [PMID 21685874]; GO_process: GO:0043971 - histone H3-K18 acetylation [Evidence IMP] [PMID 21685874]; GO_process: GO:0043970 - histone H3-K9 acetylation [Evidence IMP] [PMID 21685874]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 21685874]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
similar to AA sequence:KEGG_Orthology:K00995
Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9799363]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008444 - CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [Evidence IEA]; GO_function: GO:0008444 - CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [Evidence IMP] [PMID 9545322]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IMP] [PMID 9545322]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006655 - phosphatidylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
mitochondrial 37S ribosomal protein YmS18
similar to AA sequence:KEGG_Orthology:K02948
Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 12392552]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06116
DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0000121 - glycerol-1-phosphatase activity [Evidence IEA]; GO_function: GO:0000121 - glycerol-1-phosphatase activity [Evidence IDA] [PMID 8662716]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IDA] [PMID 8662716]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006114 - glycerol biosynthetic process [Evidence IMP] [PMID 11058591]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IDA] [PMID 8662716]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08286
similar to AA sequence:KEGG_Orthology:K14635
3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA in error-free bypass pathway, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; similar to FANCM human Fanconi anemia complementation group protein that with MHF complex is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10880470]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19995966]; GO_function: GO:0043138 - 3'-5' DNA helicase activity [Evidence IDA] [PMID 15634678]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0070336 - flap-structured DNA binding [Evidence IDA] [PMID 19181670]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0033567 - DNA replication, Okazaki fragment processing [Evidence IGI] [PMID 19181670]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0060543 - negative regulation of strand invasion [Evidence IDA,IMP] [PMID 19136626]; GO_process: GO:0000725 - recombinational repair [Evidence IMP] [PMID 19995966]
similar to AA sequence:KEGG_Orthology:K14642
Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10551827]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 10409709]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0017110 - nucleoside-diphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 10409709]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0006887 - exocytosis [Evidence IEA,IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048278 - vesicle docking [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 18332110]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12524434]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 7969142]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 11285273]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IGI,IMP] [PMID 9560393]; GO_process: GO:0016311 - dephosphorylation [Evidence IMP] [PMID 18332110]
Component of the exomer complex; exomer also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0034044 - exomer complex [Evidence IDA] [PMID 17000877]; GO_component: GO:0034044 - exomer complex [Evidence IDA] [PMID 23000721]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 11879634]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 16498409]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 9111317]; GO_process: GO:0006039 - cell wall chitin catabolic process [Evidence IMP] [PMID 9111317]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 16498409]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 9111317]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IDA] [PMID 17000877]; GO_process: GO:0006810 - transport [Evidence IEA]
H(+)-transporting V1 sector ATPase subunit F
similar to AA sequence:KEGG_Orthology:K02151
Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11780757]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0033180 - proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
homeodomain family transcription factor STE12
similar to AA sequence:KEGG_Orthology:K11215
phosphatidylethanolamine N-methyltransferase
similar to AA sequence:KEGG_Orthology:K16369
Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 2445736]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IDA,IGI] [PMID 2445736]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IDA,IMP] [PMID 3066687]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 23000174]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA,IGI] [PMID 2445736]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA,IMP] [PMID 3066687]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12587
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 8534909]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IMP] [PMID 11030620]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18591258]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18007593]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16924500]; GO_component: GO:0005886 - plasma membrane [Evidence IMP] [PMID 9691030]; GO_function: GO:0015169 - glycerol-3-phosphate transmembrane transporter activity [Evidence IGI,IMP] [PMID 20133652]; GO_function: GO:0001406 - glycerophosphodiester transmembrane transporter activity [Evidence IDA] [PMID 16924500]; GO_function: GO:0001406 - glycerophosphodiester transmembrane transporter activity [Evidence IMP] [PMID 9691030]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015794 - glycerol-3-phosphate transport [Evidence IGI,IMP] [PMID 20133652]; GO_process: GO:0001407 - glycerophosphodiester transport [Evidence IDA] [PMID 16924500]; GO_process: GO:0001407 - glycerophosphodiester transport [Evidence IMP] [PMID 9691030]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 9691030]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11539
similar to AA sequence:KEGG_Orthology:K01920
Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 12406228]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004363 - glutathione synthase activity [Evidence IEA,IEA]; GO_function: GO:0004363 - glutathione synthase activity [Evidence IDA] [PMID 9512666]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IMP] [PMID 9512666]
similar to AA sequence:KEGG_Orthology:K08158
Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 19806183]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11452010]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 20498295]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20498295]
mitochondrial 54S ribosomal protein YmL28
similar to AA sequence:KEGG_Orthology:K17421
Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1324172]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 1324172]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence ISS] [PMID 1324172]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 1324172]
similar to AA sequence:KEGG_Orthology:K05906
similar to AA sequence:KEGG_Orthology:K03320
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11069679]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9482721]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14002
One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 7744969]; GO_function: GO:0051087 - chaperone binding [Evidence IMP,ISS] [PMID 9817751]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IMP] [PMID 9817751]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP] [PMID 9817751]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17496
Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 12437924]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 12437925]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030943 - mitochondrion targeting sequence binding [Evidence IDA] [PMID 18418384]; GO_function: GO:0030943 - mitochondrion targeting sequence binding [Evidence IDA] [PMID 19144822]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 16763150]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 12437924]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 12437925]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0046902 - regulation of mitochondrial membrane permeability [Evidence IDA] [PMID 16763150]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8654588]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Poly(rA)-binding protein; involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(III) and 2-oxoglutarate; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0031418 - L-ascorbic acid binding [Evidence IEA,IEA]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_function: GO:0016706 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA] [PMID 20040577]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP] [PMID 16809762]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 16809762]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 20630870]
BAR domain-containing protein that localizes to Golgi vesicles; the Golgi vesicles it localizes to are both early and late; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 16107716]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 18156177]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 18156177]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 18156177]
similar to AA sequence:KEGG_Orthology:K15305
Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0000306 - extrinsic component of vacuolar membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14528018]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA,IMP] [PMID 19037259]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IGI,IMP] [PMID 11889142]; GO_process: GO:0033674 - positive regulation of kinase activity [Evidence IGI,IMP] [PMID 11889142]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08876
Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17203074]; GO_component: GO:0005643 - nuclear pore [Evidence IDA,IPI] [PMID 17203074]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 17203074]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP,IPI] [PMID 17203074]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI] [PMID 22008473]
DEAD-box ATP-dependent RNA helicase DBP2
similar to AA sequence:KEGG_Orthology:K12823
ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; interacts with YRA1; required for the assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22679025]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23721653]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA,IMP] [PMID 22679025]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1990120 - messenger ribonucleoprotein complex assembly [Evidence IMP] [PMID 23721653]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IGI,IMP] [PMID 22679025]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IPI] [PMID 7883168]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11585918]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
amino acid starvation-responsive transcription factor GCN4
Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12514182]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 10622712]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IDA] [PMID 10622712]
Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 8226802]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 20657825]; GO_process: GO:0007535 - donor selection [Evidence IGI] [PMID 22496671]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
similar to AA sequence:KEGG_Orthology:K01768
Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22575457]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22575457]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2196438]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004016 - adenylate cyclase activity [Evidence IEA,IEA]; GO_function: GO:0004016 - adenylate cyclase activity [Evidence IDA] [PMID 2934138]; GO_function: GO:0004016 - adenylate cyclase activity [Evidence IMP] [PMID 6360999]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016849 - phosphorus-oxygen lyase activity [Evidence IEA]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI] [PMID 2934138]; GO_process: GO:0007188 - adenylate cyclase-modulating G-protein coupled receptor signaling pathway [Evidence IGI] [PMID 2934138]; GO_process: GO:0006171 - cAMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009190 - cyclic nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))
similar to AA sequence:KEGG_Orthology:K17743
Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0032866 - D-xylose:NADP reductase activity [Evidence IDA,IMP] [PMID 11481678]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IEA]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA] [PMID 11525399]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IDA] [PMID 11525399]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0019388 - galactose catabolic process [Evidence IGI] [PMID 18811659]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence ISS] [PMID 11380987]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10389
similar to AA sequence:KEGG_Orthology:K00772
Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8807288]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0017061 - S-methyl-5-thioadenosine phosphorylase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0017061 - S-methyl-5-thioadenosine phosphorylase activity [Evidence IDA,IMP] [PMID 14506228]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0004645 - phosphorylase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IDA,IMP] [PMID 14506228]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IMP] [PMID 8807288]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006166 - purine ribonucleoside salvage [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18724
NADH-ubiquinone reductase (H(+)-translocating) NDE2
similar to AA sequence:KEGG_Orthology:K17871
Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 9733747]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence ISS] [PMID 9696750]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence ISS] [PMID 9733747]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IGI,IMP,ISS] [PMID 9733747]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00326
Microsomal cytochrome b reductase; not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IEA]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IDA] [PMID 14930]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00928
Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0004072 - aspartate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004072 - aspartate kinase activity [Evidence IDA,IMP] [PMID 18626862]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009090 - homoserine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IDA,IMP] [PMID 18626862]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 4380684]
similar to AA sequence:KEGG_Orthology:K15731
Plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR2 has a paralog, PSR1, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10777497]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence ISA] [PMID 10777497]; GO_process: GO:0071472 - cellular response to salt stress [Evidence IGI] [PMID 10777497]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11806
Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15367670]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 8508778]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8508778]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15926887]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 17176761]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP,ISS] [PMID 9811642]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015672 - monovalent inorganic cation transport [Evidence IMP,ISS] [PMID 9811642]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Essential nuclear envelope integral membrane protein; required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11483521]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IGI] [PMID 20016074]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16732
Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 22842922]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 7559759]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 7559759]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 7559759]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 12591913]; GO_process: GO:0000910 - cytokinesis [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 16615892]; GO_process: GO:0001578 - microtubule bundle formation [Evidence IDA] [PMID 12591913]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IEA]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 12591913]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IGI,IMP] [PMID 7559759]; GO_process: GO:0043148 - mitotic spindle stabilization [Evidence IMP] [PMID 9036857]; GO_process: GO:0051255 - spindle midzone assembly [Evidence IMP] [PMID 17562791]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 16688214]
Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008696 - 4-amino-4-deoxychorismate lyase activity [Evidence IEA]; GO_function: GO:0008696 - 4-amino-4-deoxychorismate lyase activity [Evidence IDA] [PMID 17873082]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IMP] [PMID 17873082]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01079
Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IBA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004647 - phosphoserine phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004647 - phosphoserine phosphatase activity [Evidence IMP] [PMID 1326413]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IMP] [PMID 1326413]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
TFIIH/NER complex ATPase/helicase subunit SSL2
similar to AA sequence:KEGG_Orthology:K10843
Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to the cytosol in response to hypoxia; homolog of human ERCC3; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 7961739]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0097550 - transcriptional preinitiation complex [Evidence IDA] [PMID 22751016]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 8202161]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IDA] [PMID 22751016]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0033683 - nucleotide-excision repair, DNA incision [Evidence IDA] [PMID 8631896]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 17212653]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IMP] [PMID 10713451]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 10713167]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0010525 - regulation of transposition, RNA-mediated [Evidence IMP] [PMID 10713167]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001113 - transcriptional open complex formation at RNA polymerase II promoter [Evidence IMP] [PMID 10409754]
Putative histone acetylase with a role in transcriptional silencing; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence ISS] [PMID 9175471]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 16199888]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 17078097]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 21057056]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 21057056]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 21057056]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 12192040]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17526727]
Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence ISS] [PMID 11380987]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
1-phosphatidylinositol-3-phosphate 5-kinase
similar to AA sequence:KEGG_Orthology:K00921
1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 9763421]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9763421]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity [Evidence IMP] [PMID 9763421]; GO_function: GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity [Evidence IDA,IMP] [PMID 9811604]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IMP] [PMID 9763421]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA,IMP] [PMID 9811604]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01866
Mitochondrial tyrosyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3315228]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IGI,ISS] [PMID 3315228]; GO_process: GO:0070184 - mitochondrial tyrosyl-tRNA aminoacylation [Evidence IGI,ISS] [PMID 3315228]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IEA]
Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003839 - gamma-glutamylcyclotransferase activity [Evidence IDA,IMP] [PMID 23070364]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IDA,IMP] [PMID 23070364]
similar to AA sequence:KEGG_Orthology:K03685
Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15090619]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15090619]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IDA] [PMID 15766245]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034963 - box C/D snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0034964 - box H/ACA snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 17991894]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IMP] [PMID 17158880]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17991894]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 17991894]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 22576366]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IDA,IMP,IPI] [PMID 19818713]
similar to AA sequence:KEGG_Orthology:K01515
Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19251690]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0047631 - ADP-ribose diphosphatase activity [Evidence IEA]; GO_function: GO:0047631 - ADP-ribose diphosphatase activity [Evidence IDA] [PMID 10542272]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0019693 - ribose phosphate metabolic process [Evidence IDA] [PMID 10542272]; GO_process: GO:0019693 - ribose phosphate metabolic process [Evidence IDA] [PMID 12370179]
similar to AA sequence:KEGG_Orthology:K17822
similar to AA sequence:KEGG_Orthology:K05994
Putative aminopeptidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00287
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 1427091]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 2827121]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 2838385]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IEA,IEA]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IMP] [PMID 1427091]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IMP] [PMID 2827121]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IDA] [PMID 2838385]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0046452 - dihydrofolate metabolic process [Evidence IMP] [PMID 1427091]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IEA]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IMP] [PMID 1427091]
tyrosine/serine/threonine protein phosphatase PPS1
similar to AA sequence:KEGG_Orthology:K04459
NAD dependent epimerase/dehydratase family protein
XP_001275318|NAD dependent epimerase/dehydratase family protein [Aspergillus clavatus NRRL 1]
similar to AA sequence:KEGG_Orthology:K01764
Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS); GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 1656231]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IEA,IEA]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IDA] [PMID 3034577]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IDA] [PMID 3034577]
decapping enzyme complex catalytic subunit DCP1
similar to AA sequence:KEGG_Orthology:K12613
similar to AA sequence:KEGG_Orthology:K06646
similar to AA sequence:KEGG_Orthology:K18163
Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 16270032]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IGI] [PMID 16270032]
similar to AA sequence:KEGG_Orthology:K12879
Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids; GO_component: GO:0000445 - THO complex part of transcription export complex [Evidence IPI] [PMID 11979277]; GO_component: GO:0000446 - nucleoplasmic THO complex [Evidence IMP,IPI] [PMID 11060033]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11139493]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IDA] [PMID 12093753]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 11060033]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 11979277]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 12093753]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 17960421]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]
Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 18806213]; GO_process: GO:0009967 - positive regulation of signal transduction [Evidence IMP] [PMID 18806213]
Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
cAMP-dependent protein kinase catalytic subunit TPK2
similar to AA sequence:KEGG_Orthology:K04345
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005952 - cAMP-dependent protein kinase complex [Evidence IDA,IPI] [PMID 12024012]; GO_component: GO:0005952 - cAMP-dependent protein kinase complex [Evidence IGI] [PMID 3036373]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12024012]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18417610]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004691 - cAMP-dependent protein kinase activity [Evidence IEA]; GO_function: GO:0004691 - cAMP-dependent protein kinase activity [Evidence IDA] [PMID 12024012]; GO_function: GO:0004691 - cAMP-dependent protein kinase activity [Evidence IGI,ISS] [PMID 3036373]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI,ISS] [PMID 3036373]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12150916]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0010737 - protein kinase A signaling [Evidence IGI] [PMID 20133652]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 12024012]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]
similar to AA sequence:KEGG_Orthology:K13335
Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
H(+)-transporting V0 sector ATPase subunit d
similar to AA sequence:KEGG_Orthology:K02146
Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8509410]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IDA,IMP] [PMID 8509410]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]; GO_process: GO:0007034 - vacuolar transport [Evidence IDA,IMP] [PMID 8509410]
similar to AA sequence:KEGG_Orthology:K11872
Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 11076031]; GO_process: GO:0010995 - free ubiquitin chain depolymerization [Evidence IMP] [PMID 11076031]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07126
Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9314530]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 9314530]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 9234668]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 17142567]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 9234668]
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14688
Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 9712830]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015087 - cobalt ion transmembrane transporter activity [Evidence IMP] [PMID 1508175]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence ISS] [PMID 9075641]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IGI] [PMID 8058041]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 10856230]; GO_process: GO:0006824 - cobalt ion transport [Evidence IMP] [PMID 1508175]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IGI] [PMID 8058041]
Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 15536122]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8948441]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015505 - uracil:cation symporter activity [Evidence IDA] [PMID 8948441]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8948441]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0015857 - uracil transport [Evidence IDA] [PMID 8948441]
similar to AA sequence:KEGG_Orthology:K15361
Ubiquitin-binding hypothetical protein; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K14654
Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008703 - 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [Evidence IEA]; GO_function: GO:0008703 - 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [Evidence IDA] [PMID 23620735]; GO_function: GO:0008703 - 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [Evidence IMP] [PMID 4555411]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]
similar to AA sequence:KEGG_Orthology:K02732
Beta 6 subunit of the 20S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
microfibrillar-associated protein family protein
similar to AA sequence:KEGG_Orthology:K13110
similar to AA sequence:KEGG_Orthology:K12670
Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12860997]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 1724755]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IMP] [PMID 12974639]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 1724755]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IDA] [PMID 1724755]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0018279 - protein N-linked glycosylation via asparagine [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
similar to AA sequence:KEGG_Orthology:K01106
Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11094088]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11094088]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9560389]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IMP] [PMID 9438131]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 10224048]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9438131]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,IMP,IPI,ISS] [PMID 10508155]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 18809726]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IDA] [PMID 11118206]
ribonucleotide-diphosphate reductase subunit RNR1
similar to AA sequence:KEGG_Orthology:K10807
Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12732713]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9315670]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IEA]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IDA] [PMID 10716984]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IDA] [PMID 16537479]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA,IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10535923]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10716984]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 11893751]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IMP] [PMID 8552025]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 10535923]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 5459124]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K05696
Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 11169758]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Cytoplasmic hypothetical protein; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
hypothetical protein; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence ISS] [PMID 10029995]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 19751518]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 10029995]
Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress; GO_component: GO:0031011 - Ino80 complex [Evidence IEA]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
putative Na(+)-exporting P-type ATPase ENA5
Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 7664728]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence ISS] [PMID 7664728]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008554 - sodium-exporting ATPase activity, phosphorylative mechanism [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence ISS] [PMID 7664728]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 7664728]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09510
similar to AA sequence:KEGG_Orthology:K11131
Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IPI] [PMID 9472021]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 9472021]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA] [PMID 15962000]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence ISA] [PMID 8710514]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IMP] [PMID 9472021]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000495 - box H/ACA snoRNA 3'-end processing [Evidence IMP] [PMID 15964797]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9472021]; GO_process: GO:0031118 - rRNA pseudouridine synthesis [Evidence IMP] [PMID 9472021]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15962000]
ubiquitin-binding ESCRT-I subunit protein STP22
similar to AA sequence:KEGG_Orthology:K12183
Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype; GO_component: GO:0000813 - ESCRT I complex [Evidence IDA] [PMID 15044434]; GO_component: GO:0000813 - ESCRT I complex [Evidence IPI] [PMID 16615894]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0009898 - cytoplasmic side of plasma membrane [Evidence IDA] [PMID 20028738]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA,IPI] [PMID 11511343]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 19380877]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 17145965]; GO_process: GO:1902915 - negative regulation of protein polyubiquitination [Evidence IMP] [PMID 23645667]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
Nem1-Spo7 phosphatase catalytic subunit NEM1
similar to AA sequence:KEGG_Orthology:K17617
similar to AA sequence:KEGG_Orthology:K10396
Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 1618910]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IGI] [PMID 1618910]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007019 - microtubule depolymerization [Evidence IMP] [PMID 19041752]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 9813090]; GO_process: GO:0030541 - plasmid partitioning [Evidence IMP] [PMID 19364922]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 9813090]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618897]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618910]
H(+)-transporting V1 sector ATPase subunit C
similar to AA sequence:KEGG_Orthology:K02148
Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11717306]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033180 - proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
similar to AA sequence:KEGG_Orthology:K17989
Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006565 - L-serine catabolic process [Evidence IGI] [PMID 7042346]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006567 - threonine catabolic process [Evidence IGI] [PMID 7042346]
Rho family guanine nucleotide exchange factor CDC24
similar to AA sequence:KEGG_Orthology:K11236
Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12175
similar to AA sequence:KEGG_Orthology:K13289
Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
similar to AA sequence:KEGG_Orthology:K14213
Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14565
Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 10094313]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IPI] [PMID 10733567]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9372940]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10094313]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10094313]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10094313]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18102
similar to AA sequence:KEGG_Orthology:K01191
Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 3281936]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence ISS] [PMID 2675832]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IDA] [PMID 3281936]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0015923 - mannosidase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence ISS] [PMID 2675832]; GO_process: GO:0006013 - mannose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009313 - oligosaccharide catabolic process [Evidence IMP] [PMID 12723970]
similar to AA sequence:KEGG_Orthology:K16368
Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11481671]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 11481671]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0004143 - diacylglycerol kinase activity [Evidence IDA] [PMID 18458075]; GO_function: GO:0004143 - diacylglycerol kinase activity [Evidence IDA] [PMID 18458076]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IMP] [PMID 18458075]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IDA] [PMID 18458076]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
hypothetical protein that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IEA]; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K02882
Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23874617]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 23874617]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 23874617]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12772
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IEP] [PMID 3540611]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00059
DNA-directed RNA polymerase II core subunit RPO21
similar to AA sequence:KEGG_Orthology:K03006
RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IEA]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3299050]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0019985 - translesion synthesis [Evidence IMP] [PMID 22405652]
Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23047103]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IGI,IMP] [PMID 23047103]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12160
Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 16782016]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10364461]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10579719]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 10364461]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 10579719]; GO_function: GO:0031386 - protein tag [Evidence IDA] [PMID 10364461]; GO_function: GO:0031386 - protein tag [Evidence IDA] [PMID 10579719]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA] [PMID 9312010]
Asn and gln rich hypothetical protein; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K05527
similar to AA sequence:KEGG_Orthology:K01647
Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IEA,IEA]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IDA,IMP] [PMID 17570335]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0046356 - acetyl-CoA catabolic process [Evidence IDA,IMP] [PMID 17570335]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006101 - citrate metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
hypothetical protein; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 10923024]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 15002745]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006810 - transport [Evidence IEA]
Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 22343720]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 22343720]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0034968 - histone lysine methylation [Evidence IDA,IMP] [PMID 22343720]; GO_process: GO:0032259 - methylation [Evidence IEA]
hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K15436
Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9412460]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9545233]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IPI] [PMID 9545233]; GO_process: GO:0006404 - RNA import into nucleus [Evidence IMP] [PMID 16040803]; GO_process: GO:0006404 - RNA import into nucleus [Evidence IMP] [PMID 17409072]; GO_process: GO:0006403 - RNA localization [Evidence IMP] [PMID 12167699]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9412460]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9545233]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9412460]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9545233]; GO_process: GO:0051031 - tRNA transport [Evidence IMP] [PMID 17409072]; GO_process: GO:0051031 - tRNA transport [Evidence IMP] [PMID 20032305]
similar to AA sequence:KEGG_Orthology:K01934
5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030272 - 5-formyltetrahydrofolate cyclo-ligase activity [Evidence IEA,IEA]; GO_function: GO:0030272 - 5-formyltetrahydrofolate cyclo-ligase activity [Evidence IDA] [PMID 11923304]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IDA] [PMID 11923304]
branched-chain-amino-acid transaminase BAT2
Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21267457]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0052656 - L-isoleucine transaminase activity [Evidence IEA]; GO_function: GO:0052654 - L-leucine transaminase activity [Evidence IEA]; GO_function: GO:0052655 - L-valine transaminase activity [Evidence IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IDA] [PMID 8798704]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,IMP] [PMID 8798704]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IMP] [PMID 8702755]; GO_process: GO:0009081 - branched-chain amino acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08272
Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12972564]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12972564]; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 11259593]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12972564]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 12972564]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 11259593]; GO_process: GO:0008360 - regulation of cell shape [Evidence IGI] [PMID 11259593]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 12972564]
similar to AA sequence:KEGG_Orthology:K12190
Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome; plays a role in the formation of mutant huntingtin (Htt) aggregates in yeast; GO_component: GO:0000814 - ESCRT II complex [Evidence IDA] [PMID 12194858]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 15029239]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 19380877]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000433 - negative regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 11278625]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12194858]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
mitochondrial 37S ribosomal protein PET123
Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
similar to AA sequence:KEGG_Orthology:K08991
Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p; GO_component: GO:0048476 - Holliday junction resolvase complex [Evidence IDA] [PMID 17363897]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP,IPI] [PMID 10905349]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008821 - crossover junction endodeoxyribonuclease activity [Evidence IDA] [PMID 17363897]; GO_function: GO:0004520 - endodeoxyribonuclease activity [Evidence IDA] [PMID 11641278]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA,IEA]; GO_process: GO:0006259 - DNA metabolic process [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI] [PMID 12032096]; GO_process: GO:0006265 - DNA topological change [Evidence IGI] [PMID 11139495]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 11139495]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IGI,IMP] [PMID 23071463]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI] [PMID 11641278]; GO_process: GO:0000712 - resolution of meiotic recombination intermediates [Evidence IGI] [PMID 18691964]
ATP-binding cassette long-chain fatty acid transporter PXA2
similar to AA sequence:KEGG_Orthology:K15628
Subunit of a heterodimeric peroxisomal ABC transport complex; required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; complex also includes Pxa1p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 9395310]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IDA] [PMID 9395310]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1902001 - fatty acid transmembrane transport [Evidence IDA] [PMID 9395310]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00435
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IEA]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IMP] [PMID 10589830]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA] [PMID 17580971]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA,IMP] [PMID 21334283]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10589830]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18669
Enhanced Adherence to Polystyrene; similar to S. pombe predicted GPI-anchored SPBPJ4664.02; similar to RBT1; internal hexapeptide PATEST repeat region is expanded in allelic CaP19.8979; identical to C. albicans morphogenetic related gene CPH3 (AAM46085); no clear allele
Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 12707309]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]
Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0033116 - endoplasmic reticulum-Golgi intermediate compartment membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01056
One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IGI] [PMID 12475929]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IDA] [PMID 12799450]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 12799450]
similar to AA sequence:KEGG_Orthology:K01852
Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 11706015]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016866 - intramolecular transferase activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000250 - lanosterol synthase activity [Evidence IEA]; GO_function: GO:0000250 - lanosterol synthase activity [Evidence IMP] [PMID 18842050]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00020
similar to AA sequence:KEGG_Orthology:K18103
similar to AA sequence:KEGG_Orthology:K03841
Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12686616]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 196563]; GO_component: GO:0042597 - periplasmic space [Evidence IDA] [PMID 22833678]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity [Evidence IMP] [PMID 2841162]; GO_function: GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity [Evidence IDA] [PMID 6304022]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 6321183]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0072593 - reactive oxygen species metabolic process [Evidence IMP] [PMID 16199065]
Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 11536335]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11536335]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 11536335]
similar to AA sequence:KEGG_Orthology:K14777
Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 16449634]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14859
Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence ISS] [PMID 11864607]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12702244]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IPI] [PMID 11864606]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IGI] [PMID 7748491]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence ISS] [PMID 11864607]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase
RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11526110]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11526110]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11526110]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 11526110]
Usp (universal stress protein) family protein, implicated in meiotic chromosome segregation
similar to AA sequence:KEGG_Orthology:K00966
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IDA,IMP] [PMID 9195935]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IDA,IMP] [PMID 9195935]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 11055399]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9195935]
translation initiation factor eIF2 subunit gamma
similar to AA sequence:KEGG_Orthology:K03242
Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID); GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 12008673]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IMP] [PMID 8417348]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IMP] [PMID 8947054]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 22683627]; GO_function: GO:0000049 - tRNA binding [Evidence IMP] [PMID 8947054]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 23063529]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA] [PMID 22683627]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IMP] [PMID 9308967]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 23063529]
leucine-responsive transcriptional regulator LEU3
similar to AA sequence:KEGG_Orthology:K09242
similar to AA sequence:KEGG_Orthology:K03538
Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IEA]; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IPI] [PMID 17881380]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0030677 - ribonuclease P complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 23700311]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IDA] [PMID 17881380]; GO_function: GO:0000171 - ribonuclease MRP activity [Evidence IMP] [PMID 9085845]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IMP] [PMID 9085845]; GO_function: GO:0004540 - ribonuclease activity [Evidence IEA]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0034965 - intronic box C/D snoRNA processing [Evidence IDA] [PMID 18713869]; GO_process: GO:0006379 - mRNA cleavage [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 14729943]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9085845]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9085845]
similar to AA sequence:KEGG_Orthology:K03800
Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19570983]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016979 - lipoate-protein ligase activity [Evidence ISA] [PMID 19570983]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IMP] [PMID 19570983]
S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 21858014]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IMP] [PMID 22522802]; GO_process: GO:0018022 - peptidyl-lysine methylation [Evidence IMP] [PMID 22522802]
similar to AA sequence:KEGG_Orthology:K00624
Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18427809]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence ISS] [PMID 11329169]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006066 - alcohol metabolic process [Evidence IGI] [PMID 11329169]; GO_process: GO:0009437 - carnitine metabolic process [Evidence IMP] [PMID 11329169]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05607
3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IDA,ISS] [PMID 12697341]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12697341]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006574 - valine catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02989
Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 385049]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 385049]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence ISA] [PMID 17901157]; GO_process: GO:0006412 - translation [Evidence IEA]
Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 20739461]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 20739461]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 20956561]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:2000397 - positive regulation of ubiquitin-dependent endocytosis [Evidence IMP] [PMID 20956561]; GO_process: GO:0032386 - regulation of intracellular transport [Evidence IMP] [PMID 20739461]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
methylenetetrahydrofolate reductase (NAD(P)H) MET13
similar to AA sequence:KEGG_Orthology:K00297
Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IEA,IEA]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IDA,ISS] [PMID 10600168]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence ISS] [PMID 8896269]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP,ISS] [PMID 10029993]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP,ISS] [PMID 10600168]; GO_process: GO:0006555 - methionine metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication; GO_component: GO:0008623 - CHRAC [Evidence IPI] [PMID 14673157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence TAS] [PMID 12370299]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 14673157]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP] [PMID 12624196]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14569
GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA,IMP] [PMID 16307926]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,IMP] [PMID 16307926]; GO_function: GO:0034511 - U3 snoRNA binding [Evidence IDA] [PMID 16307926]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IDA] [PMID 11565749]; GO_process: GO:0042255 - ribosome assembly [Evidence IDA] [PMID 11565749]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
H(+)-transporting V0 sector ATPase subunit a
similar to AA sequence:KEGG_Orthology:K02154
Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11592965]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11948198]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11592965]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IDA,ISS] [PMID 7514599]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IGI,ISS] [PMID 7514599]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IEP,IGI,IMP,ISS] [PMID 11278748]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI] [PMID 7514599]
Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K11547
Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation; GO_component: GO:0031262 - Ndc80 complex [Evidence IDA,IPI] [PMID 11179222]; GO_component: GO:0031262 - Ndc80 complex [Evidence IDA] [PMID 11266451]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IMP,IPI] [PMID 11179222]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA,IGI,IPI] [PMID 11266451]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI,IMP] [PMID 11266451]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19893618]
similar to AA sequence:KEGG_Orthology:K01918
Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004592 - pantoate-beta-alanine ligase activity [Evidence IEA,IEA]; GO_function: GO:0004592 - pantoate-beta-alanine ligase activity [Evidence IDA,ISS] [PMID 10417331]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]
similar to AA sequence:KEGG_Orthology:K12815
DEAH-box RNA helicase involved in second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 1825134]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 1825134]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 1825134]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000378 - RNA exon ligation [Evidence IDA] [PMID 23685439]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 16103217]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 1825134]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
mitochondrial 54S ribosomal protein YmL20
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
ribosome dissociation factor GTPase HBS1
similar to AA sequence:KEGG_Orthology:K14416
GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 20947765]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 21623367]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 19481524]; GO_process: GO:0070966 - nuclear-transcribed mRNA catabolic process, no-go decay [Evidence IGI] [PMID 16554824]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP] [PMID 24424461]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0032790 - ribosome disassembly [Evidence IDA] [PMID 20947765]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08492
similar to AA sequence:KEGG_Orthology:K13337
Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9418908]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16009135]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9418908]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0033328 - peroxisome membrane targeting sequence binding [Evidence IPI] [PMID 16679311]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16679311]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9418908]; GO_process: GO:0032581 - ER-dependent peroxisome organization [Evidence IMP] [PMID 20427571]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IPI] [PMID 22486971]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0032527 - protein exit from endoplasmic reticulum [Evidence IMP] [PMID 16009135]; GO_process: GO:0045046 - protein import into peroxisome membrane [Evidence IMP] [PMID 10637226]; GO_process: GO:0050821 - protein stabilization [Evidence IPI] [PMID 16679311]
Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
mitochondrial 37S ribosomal protein MRPS5
similar to AA sequence:KEGG_Orthology:K02988
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03137
TFIIE small subunit; involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IEA]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 1429681]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 7961670]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IPI] [PMID 9188494]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0001097 - TFIIH-class transcription factor binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9271406]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1429681]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7961670]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9405484]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 9182565]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 9182565]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015432 - bile acid-exporting ATPase activity [Evidence IMP] [PMID 9182565]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015721 - bile acid and bile salt transport [Evidence IMP] [PMID 9182565]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K06671
Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 22912589]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 9990856]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10028182]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9990856]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0000755 - cytogamy [Evidence IMP] [PMID 10028182]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 17229992]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 9990856]; GO_process: GO:0009847 - spore germination [Evidence IMP] [PMID 10028182]
similar to AA sequence:KEGG_Orthology:K14408
Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10660071]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10660071]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 15215336]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 15215336]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17714
similar to AA sequence:KEGG_Orthology:K15325
similar to AA sequence:KEGG_Orthology:K07393
Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16936141]; GO_function: GO:0045174 - glutathione dehydrogenase (ascorbate) activity [Evidence IEA]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IEA]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IDA,ISS] [PMID 16709151]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence ISS] [PMID 16709151]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
bifunctional endoribonuclease/protein kinase IRE1
similar to AA sequence:KEGG_Orthology:K08852
similar to AA sequence:KEGG_Orthology:K05275
Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0050236 - pyridoxine:NADP 4-dehydrogenase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0042820 - vitamin B6 catabolic process [Evidence IEA]
Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein, BiP (Kar2p); GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 2178921]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 2178921]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 2178921]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
cAMP-dependent protein kinase regulatory subunit BCY1
similar to AA sequence:KEGG_Orthology:K04739
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; GO_component: GO:0005952 - cAMP-dependent protein kinase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11134339]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11134339]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18417610]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3288487]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2831892]; GO_function: GO:0030552 - cAMP binding [Evidence IEA]; GO_function: GO:0004862 - cAMP-dependent protein kinase inhibitor activity [Evidence IDA] [PMID 3037314]; GO_function: GO:0004862 - cAMP-dependent protein kinase inhibitor activity [Evidence IMP] [PMID 6292221]; GO_function: GO:0008603 - cAMP-dependent protein kinase regulator activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence IDA,IMP] [PMID 3037314]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0045859 - regulation of protein kinase activity [Evidence IEA]; GO_process: GO:0001932 - regulation of protein phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K19001
Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 10077188]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 18085829]
Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 8980231]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16461455]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8980231]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA,IMP] [PMID 15870268]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 10329629]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10196219]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 10196219]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 10196219]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 10196219]; GO_process: GO:0009408 - response to heat [Evidence IGI] [PMID 11589572]
similar to AA sequence:KEGG_Orthology:K14713
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16760462]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IMP] [PMID 16760462]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 16760462]
similar to AA sequence:KEGG_Orthology:K14816
Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15107529]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 16648468]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 19433447]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16648468]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19433447]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI] [PMID 15107529]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IGI] [PMID 15107529]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 16651379]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI,IMP] [PMID 16648468]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 16651379]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14799
Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15167894]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11565749]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15167894]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IDA] [PMID 15167894]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12089522]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 11565749]
Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 11154269]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP,ISS] [PMID 16524914]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IDA] [PMID 16778074]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 16524914]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 16778074]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0043200 - response to amino acid [Evidence IGI,IMP] [PMID 11154269]
similar to AA sequence:KEGG_Orthology:K12591
putative serine/threonine protein kinase ENV7
similar to AA sequence:KEGG_Orthology:K08856
similar to AA sequence:KEGG_Orthology:K17608
Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway; GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IMP,ISS] [PMID 8001155]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 9427388]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8001155]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
translation initiation factor eIF2 subunit beta
similar to AA sequence:KEGG_Orthology:K03238
Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 12008673]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IDA,IMP] [PMID 12137565]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 9858542]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 12137565]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 22683627]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 9395514]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 16449648]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01684
similar to AA sequence:KEGG_Orthology:K11517
Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23651256]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence ISS] [PMID 10207060]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 23651256]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0009074 - aromatic amino acid family catabolic process [Evidence IMP] [PMID 10207060]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10207060]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006572 - tyrosine catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00065
mRNA-binding ubiquitin-specific protease UBP3
similar to AA sequence:KEGG_Orthology:K11841
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; SPT16 specifically required for diauxic shift-induced H2B deposition onto rDNA genes; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome; GO_component: GO:0035101 - FACT complex [Evidence IGI,IPI] [PMID 11432837]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 10413469]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10413469]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_component: GO:0008023 - transcription elongation factor complex [Evidence IPI] [PMID 12242279]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10413469]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 18089575]; GO_function: GO:0031491 - nucleosome binding [Evidence IDA] [PMID 11432837]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0034724 - DNA replication-independent nucleosome organization [Evidence IDA] [PMID 19683499]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IPI] [PMID 9199353]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 12952948]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 15082784]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 15987999]; GO_process: GO:0060261 - positive regulation of transcription initiation from RNA polymerase II promoter [Evidence IGI] [PMID 15987999]; GO_process: GO:0060261 - positive regulation of transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 19574230]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 19683500]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IPI] [PMID 12242279]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07904
Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15537705]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15537705]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 9151665]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI] [PMID 15537705]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 9151665]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IMP] [PMID 9151665]
similar to AA sequence:KEGG_Orthology:K11086
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21135132]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18923425]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15652485]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 15652485]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 15652485]
Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9234705]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 9234705]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006448 - regulation of translational elongation [Evidence IMP,IPI] [PMID 9234705]
similar to AA sequence:KEGG_Orthology:K12763
Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 8524252]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11046133]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8524252]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2
similar to AA sequence:KEGG_Orthology:K01736
Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19793921]; GO_function: GO:0004107 - chorismate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004107 - chorismate synthase activity [Evidence IDA,IMP] [PMID 8971708]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0042602 - riboflavin reductase (NADPH) activity [Evidence IDA] [PMID 8971708]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IMP] [PMID 8971708]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Signal recognition particle receptor subunit beta
similar to AA sequence:KEGG_Orthology:K12272
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 9679135]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005785 - signal recognition particle receptor complex [Evidence IPI] [PMID 9679135]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IPI] [PMID 7844142]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 7844142]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005047 - signal recognition particle binding [Evidence IMP,IPI,ISS] [PMID 9679135]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IC,TAS] [PMID 7844142]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 9679135]
Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0032126 - eisosome [Evidence IDA] [PMID 19269952]; GO_component: GO:0032126 - eisosome [Evidence IDA,IGI] [PMID 20526336]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070941 - eisosome assembly [Evidence IMP] [PMID 20526336]
Plasma membrane protein that may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 12015967]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 12015967]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IGI] [PMID 12015967]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0007033 - vacuole organization [Evidence IGI] [PMID 12015967]
Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 15343339]; GO_component: GO:0005634 - nucleus [Evidence ISS] [PMID 9393435]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 9393435]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 17178117]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 11943201]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IPI] [PMID 11943201]; GO_process: GO:0008150 - biological_process [Evidence ND]
Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_function: GO:0004568 - chitinase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IGI] [PMID 18809304]
similar to AA sequence:KEGG_Orthology:K06653
Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16611745]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity [Evidence IMP] [PMID 11069666]; GO_function: GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity [Evidence IMP] [PMID 7939631]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IMP] [PMID 4570606]
similar to AA sequence:KEGG_Orthology:K14560
Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034457 - Mpp10 complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0032040 - small-subunit processome [Evidence IMP] [PMID 12242301]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA,IEA]; GO_function: GO:0030515 - snoRNA binding [Evidence ISS] [PMID 10409734]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 15489263]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence TAS] [PMID 11087857]
mitochondrial 54S ribosomal protein YmL16
similar to AA sequence:KEGG_Orthology:K02933
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18173
Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 17882259]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 17882260]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP,IPI] [PMID 17882259]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 17882260]
mitochondrial 54S ribosomal protein YmL9
similar to AA sequence:KEGG_Orthology:K02906
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence ISS] [PMID 1597181]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence ISS] [PMID 1597181]; GO_process: GO:0002181 - cytoplasmic translation [Evidence ISS] [PMID 1597181]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14290
Major karyopherin; involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000776 - kinetochore [Evidence IDA] [PMID 19139260]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9891088]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 18573877]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9323132]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9857197]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 9323132]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 9323132]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IGI] [PMID 19139260]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11313466]; GO_process: GO:0006810 - transport [Evidence IEA]
Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults and preservation of normal mitochondrial function under damage-eliciting conditions; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12963738]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP,ISS] [PMID 12963738]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 12963738]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K13102
Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K14674
Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16135509]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16267052]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0047499 - calcium-independent phospholipase A2 activity [Evidence IDA,IMP] [PMID 20332534]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042171 - lysophosphatidic acid acyltransferase activity [Evidence IDA] [PMID 20332534]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA,IMP] [PMID 20332534]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 16135509]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 20332534]; GO_process: GO:0007114 - cell budding [Evidence IGI,IMP] [PMID 19150427]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IMP] [PMID 20332534]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI,IMP] [PMID 16267052]; GO_process: GO:0006642 - triglyceride mobilization [Evidence IDA,IMP] [PMID 16135509]
similar to AA sequence:KEGG_Orthology:K06942
similar to AA sequence:KEGG_Orthology:K00058
3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0004617 - phosphoglycerate dehydrogenase activity [Evidence IEA]; GO_function: GO:0004617 - phosphoglycerate dehydrogenase activity [Evidence IMP] [PMID 12525494]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009070 - serine family amino acid biosynthetic process [Evidence IMP] [PMID 12525494]
proteasome regulatory particle base subunit RPN2
similar to AA sequence:KEGG_Orthology:K03032
Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000502 - proteasome complex [Evidence IEA,IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 7565784]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12200120]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17911101]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0042176 - regulation of protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 7565784]
similar to AA sequence:KEGG_Orthology:K14768
Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14767053]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 14767053]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 15282802]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23613772]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 14767053]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 14767053]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 23613772]; GO_function: GO:0005094 - Rho GDP-dissociation inhibitor activity [Evidence IGI,IPI] [PMID 15215315]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IMP] [PMID 14767053]; GO_process: GO:0035023 - regulation of Rho protein signal transduction [Evidence IGI,IPI] [PMID 15215315]
similar to AA sequence:KEGG_Orthology:K00254
Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 16107716]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 18194531]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 17178117]
similar to AA sequence:KEGG_Orthology:K17742
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11158358]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11158358]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IPI] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IDA] [PMID 3905788]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 3905788]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEP] [PMID 3905788]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K07106
Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 24919400]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 24919400]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07562
Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10022925]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 10022925]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 11105761]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 17347149]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11086007]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI] [PMID 23212245]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12604
Component of the CCR4-NOT1 core complex; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 10490603]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11889048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7926748]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IDA,IGI,IMP] [PMID 11889048]; GO_process: GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA] [PMID 11889048]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 2680756]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10490603]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0000749 - response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 2099190]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11404327]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03321
similar to AA sequence:KEGG_Orthology:K07442
Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9851972]; GO_component: GO:0031515 - tRNA (m1A) methyltransferase complex [Evidence IEA]; GO_component: GO:0031515 - tRNA (m1A) methyltransferase complex [Evidence IDA,IPI] [PMID 10779558]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016429 - tRNA (adenine-N1-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016429 - tRNA (adenine-N1-)-methyltransferase activity [Evidence IDA,IMP] [PMID 10779558]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10779558]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14547
Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 19370060]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 12794079]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
translation elongation factor 1 subunit beta
similar to AA sequence:KEGG_Orthology:K03232
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence IEA]; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence IMP] [PMID 8420802]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 17925388]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_process: GO:1990145 - maintenance of translational fidelity [Evidence IMP] [PMID 10409717]; GO_process: GO:0032232 - negative regulation of actin filament bundle assembly [Evidence IDA] [PMID 19095653]; GO_process: GO:0006449 - regulation of translational termination [Evidence IGI] [PMID 19545407]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]; GO_process: GO:0006414 - translational elongation [Evidence IMP] [PMID 10409717]
similar to AA sequence:KEGG_Orthology:K14837
Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11452019]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030684 - preribosome [Evidence IDA] [PMID 17922018]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 11452019]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11452019]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01372
Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19061865]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9584198]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 8063738]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IDA] [PMID 8063738]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 9584198]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9584198]; GO_process: GO:0043418 - homocysteine catabolic process [Evidence IDA,IMP] [PMID 16769724]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9374524]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IDA] [PMID 8063738]
similar to AA sequence:KEGG_Orthology:K01469
5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0017168 - 5-oxoprolinase (ATP-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0017168 - 5-oxoprolinase (ATP-hydrolyzing) activity [Evidence IDA,IMP] [PMID 20402795]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IMP] [PMID 20349993]
similar to AA sequence:KEGG_Orthology:K13137
WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16221974]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 16221974]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of the mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of the guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNA pol II pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is a single bifunctional polypeptide; CET1 has a paralog, CTL1, that arose from the whole genome duplication; GO_component: GO:0031533 - mRNA cap methyltransferase complex [Evidence IGI,IPI] [PMID 9710603]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004651 - polynucleotide 5'-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004651 - polynucleotide 5'-phosphatase activity [Evidence IDA] [PMID 17707331]; GO_function: GO:0004651 - polynucleotide 5'-phosphatase activity [Evidence IDA] [PMID 9345280]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IPI] [PMID 9345280]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0098507 - polynucleotide 5' dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0098501 - polynucleotide dephosphorylation [Evidence IDA] [PMID 9345280]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 24205062]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 24172134]
Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IDA] [PMID 12401799]; GO_function: GO:0004371 - glycerone kinase activity [Evidence ISS] [PMID 9038161]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0050354 - triokinase activity [Evidence IEA]; GO_process: GO:0019588 - anaerobic glycerol catabolic process [Evidence IEA]; GO_process: GO:0097237 - cellular response to toxic substance [Evidence IMP] [PMID 12401799]; GO_process: GO:0019563 - glycerol catabolic process [Evidence ISS] [PMID 9038161]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16467472]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9799362]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11839825]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 16467472]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 11839825]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_process: GO:0071322 - cellular response to carbohydrate stimulus [Evidence IMP] [PMID 11839825]; GO_process: GO:0071322 - cellular response to carbohydrate stimulus [Evidence IMP] [PMID 16467472]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 16467472]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 11839825]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
chromatin-silencing transcriptional regulator TUP1
similar to AA sequence:KEGG_Orthology:K06666
similar to AA sequence:KEGG_Orthology:K13996
ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10545109]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP,ISS] [PMID 11157982]; GO_function: GO:0019153 - protein-disulfide reductase (glutathione) activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16002399]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12881414]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 10545109]
similar to AA sequence:KEGG_Orthology:K14018
WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA,IMP] [PMID 16428438]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 12399380]; GO_process: GO:0010992 - ubiquitin homeostasis [Evidence IMP] [PMID 18508771]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 2111732]
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
similar to AA sequence:KEGG_Orthology:K12274
similar to AA sequence:KEGG_Orthology:K04713
Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8868422]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000170 - sphingosine hydroxylase activity [Evidence IMP,ISS] [PMID 9556590]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IMP,ISS] [PMID 9556590]
Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12034822]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12034822]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 12198175]; GO_function: GO:0000150 - recombinase activity [Evidence IDA,IMP] [PMID 12198175]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19729448]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 12198175]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 19074198]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IDA] [PMID 12034822]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 12198175]; GO_process: GO:0090297 - positive regulation of mitochondrial DNA replication [Evidence IMP] [PMID 17116696]; GO_process: GO:0090297 - positive regulation of mitochondrial DNA replication [Evidence IMP] [PMID 19074198]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IPI] [PMID 9736700]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
similar to AA sequence:KEGG_Orthology:K07151
Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IC] [PMID 9405463]; GO_function: GO:0004576 - oligosaccharyl transferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
mitochondrial 37S ribosomal protein MRP1
similar to AA sequence:KEGG_Orthology:K04564
Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]
Essential nuclear envelope integral membrane protein; identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15882446]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 15882446]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 15882446]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IMP] [PMID 15882446]; GO_process: GO:0006611 - protein export from nucleus [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 15882446]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01264
Vacuolar aminopeptidase Y; processed to mature form by Prb1p; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 8175799]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA] [PMID 8175799]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IMP] [PMID 8175800]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IDA] [PMID 8175799]
Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IGI,IMP] [PMID 20630870]
uroporphyrinogen-III C-methyltransferase
similar to AA sequence:KEGG_Orthology:K00589
S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 10051442]; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 9003798]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004851 - uroporphyrin-III C-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004851 - uroporphyrin-III C-methyltransferase activity [Evidence IDA] [PMID 10051442]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 1101032]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IGI,ISS] [PMID 9003798]; GO_process: GO:0000103 - sulfate assimilation [Evidence NAS] [PMID 9003798]
AN1-type zinc finger hypothetical protein; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element, a transcriptional profile similar to CUZ1 and RPN2, and decreased expression in an RPN4 mutant; induced by nitrogen limitation and weak acid; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071243 - cellular response to arsenic-containing substance [Evidence IMP] [PMID 24297164]
Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000920 - cytokinetic cell separation [Evidence IGI] [PMID 16041152]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]
similar to AA sequence:KEGG_Orthology:K09523
DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9148890]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 9148890]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 9148890]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 10069807]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 9817751]
hypothetical protein; contains FYVE domain; similar to Fab1 and Vps27; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K14827
Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene; GO_component: GO:0097344 - Rix1 complex [Evidence IDA] [PMID 14759368]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15528184]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 22421151]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 22421151]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12089522]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 14759368]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 22421151]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 15528184]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 23479637]
similar to AA sequence:KEGG_Orthology:K01758
Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0080146 - L-cysteine desulfhydrase activity [Evidence IEA]; GO_function: GO:0044540 - L-cystine L-cysteine-lyase (deaminating) [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IEA]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IMP] [PMID 10509018]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IDA] [PMID 1577698]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IMP] [PMID 8366024]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IMP] [PMID 8366024]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IMP] [PMID 10509018]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 8366024]
similar to AA sequence:KEGG_Orthology:K14001
Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IPI] [PMID 10958688]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 10958688]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IGI,IMP] [PMID 10958688]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006020 - inositol metabolic process [Evidence IMP] [PMID 16582425]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 10359606]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence ISA] [PMID 10359606]
Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8016655]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA,IMP] [PMID 8159677]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1339306]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA,IMP] [PMID 16461455]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0042393 - histone binding [Evidence IPI] [PMID 17496903]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8016655]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8221926]; GO_process: GO:0044109 - cellular alcohol catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0031496 - positive regulation of mating type switching [Evidence IMP] [PMID 6436497]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1339306]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3542227]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0005987 - sucrose catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18752
Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 19198597]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 19198597]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8849456]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IPI] [PMID 9488461]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 12524331]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IMP,IPI] [PMID 8849456]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IDA] [PMID 9488461]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI] [PMID 8849456]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP,IPI] [PMID 19366694]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02940
Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
dolichyl-phosphate-mannose-protein mannosyltransferase PMT2
Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication; GO_component: GO:0097582 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [Evidence IDA] [PMID 12551906]; GO_component: GO:0097582 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [Evidence IPI] [PMID 21956107]; GO_component: GO:0097582 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [Evidence IPI] [PMID 8543034]; GO_component: GO:0097584 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex [Evidence IDA] [PMID 12551906]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IDA,IGI] [PMID 21956107]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IGI,IMP,ISA] [PMID 7852348]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IGI,IMP] [PMID 8543034]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 18182384]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IGI] [PMID 21147851]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IMP] [PMID 9184828]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IMP] [PMID 18182384]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI] [PMID 21231968]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI,IMP] [PMID 7852348]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI,IMP] [PMID 8543034]; GO_process: GO:0032527 - protein exit from endoplasmic reticulum [Evidence IGI] [PMID 21147851]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IGI] [PMID 21231968]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IGI,IMP] [PMID 23704572]
similar to AA sequence:KEGG_Orthology:K11374
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01687
Dihydroxyacid dehydratase; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004160 - dihydroxy-acid dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0004160 - dihydroxy-acid dehydratase activity [Evidence IMP] [PMID 14124940]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IMP] [PMID 14124940]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13348
Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15189984]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23045398]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IMP] [PMID 15189984]
similar to AA sequence:KEGG_Orthology:K11303
Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8858151]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9575221]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 14761951]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA,IPI] [PMID 8858151]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 9575221]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14761951]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9575221]; GO_function: GO:0010485 - H4 histone acetyltransferase activity [Evidence IDA] [PMID 8858151]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16612003]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 7559580]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 8858151]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 9575221]; GO_function: GO:0042393 - histone binding [Evidence IEA]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 8858151]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA,IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 10982821]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 15099519]; GO_process: GO:0016573 - histone acetylation [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 7559580]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 8858151]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 9575221]
similar to AA sequence:KEGG_Orthology:K03357
Processivity factor; required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 12402045]; GO_function: GO:0090302 - mitotic anaphase-promoting complex activity [Evidence IDA] [PMID 12402045]; GO_process: GO:0007092 - activation of mitotic anaphase-promoting complex activity [Evidence IDA,IMP] [PMID 12402045]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 12402045]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0031497 - chromatin assembly [Evidence IGI] [PMID 12399376]; GO_process: GO:0008054 - cyclin catabolic process [Evidence IMP] [PMID 9348530]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01940
Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004055 - argininosuccinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004055 - argininosuccinate synthase activity [Evidence IDA] [PMID 2897249]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEP,IMP] [PMID 2897249]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]
hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K11563
Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 19893618]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 19893618]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IMP] [PMID 19893618]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19893618]; GO_process: GO:0031134 - sister chromatid biorientation [Evidence IMP] [PMID 19893618]
mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 10931938]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IGI,IMP] [PMID 12954640]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence ISS] [PMID 9653120]; GO_process: GO:0006688 - glycosphingolipid biosynthetic process [Evidence IMP,ISS] [PMID 9323360]; GO_process: GO:0006675 - mannosyl-inositol phosphorylceramide metabolic process [Evidence IMP] [PMID 9323360]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence TAS] [PMID 10366774]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 12954640]
similar to AA sequence:KEGG_Orthology:K01874
Methionyl-tRNA synthetase; forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 3905796]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IDA] [PMID 11069915]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IDA] [PMID 3312199]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IDA] [PMID 3312199]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12860
Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 10092627]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 10092627]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 10092627]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 22408182]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 10092627]
putative serine/threonine protein kinase HRK1
ribose phosphate diphosphokinase subunit PRS5
similar to AA sequence:KEGG_Orthology:K00948
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02134
Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IDA] [PMID 17082766]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IMP,IPI,ISS] [PMID 8026496]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA,IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18722382]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP,ISS] [PMID 8026496]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,IPI,ISS] [PMID 8026496]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
proteasome regulatory particle base subunit RPT2
similar to AA sequence:KEGG_Orthology:K03062
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 7721833]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0036402 - proteasome-activating ATPase activity [Evidence IGI,IMP] [PMID 11430818]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:0043171 - peptide catabolic process [Evidence IMP] [PMID 9724628]; GO_process: GO:0045732 - positive regulation of protein catabolic process [Evidence IDA] [PMID 15135049]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0031503 - protein complex localization [Evidence IMP] [PMID 23102099]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9724628]
similar to AA sequence:KEGG_Orthology:K04649
Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex (APC); GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 10848595]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,ISS] [PMID 2265617]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 10878801]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11134048]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 2265617]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IMP] [PMID 11134048]
similar to AA sequence:KEGG_Orthology:K01720
Mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0047547 - 2-methylcitrate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0047547 - 2-methylcitrate dehydratase activity [Evidence ISA] [PMID 9006051]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0019543 - propionate catabolic process [Evidence IEA]; GO_process: GO:0019629 - propionate catabolic process, 2-methylcitrate cycle [Evidence IEA]; GO_process: GO:0019629 - propionate catabolic process, 2-methylcitrate cycle [Evidence ISA] [PMID 9006051]; GO_process: GO:0019541 - propionate metabolic process [Evidence IMP] [PMID 11179416]
similar to AA sequence:KEGG_Orthology:K18097
Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 10818358]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0047953 - glycerol 2-dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:1990042 - glycerol dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 22979944]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
SCF ubiquitin ligase complex subunit GRR1
similar to AA sequence:KEGG_Orthology:K03360
F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IMP] [PMID 9736614]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 11080155]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 15775961]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11080155]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 11259599]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 9346238]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA,IMP] [PMID 9819356]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 10213692]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence TAS] [PMID 9346231]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 10213692]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0000751 - cell cycle arrest in response to pheromone [Evidence IMP] [PMID 15942932]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0071406 - cellular response to methylmercury [Evidence IMP] [PMID 17141224]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 16093347]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IGI,IPI] [PMID 9499404]
Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 17307817]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004835 - tubulin-tyrosine ligase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 17307817]
Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 10788431]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 19496824]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IMP] [PMID 10652283]; GO_function: GO:0005427 - proton-dependent oligopeptide secondary active transmembrane transporter activity [Evidence IDA] [PMID 16149917]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA] [PMID 16149917]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IEP] [PMID 11862495]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07750
C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8663358]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8663358]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IEA]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IDA] [PMID 8663358]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8663358]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
anaphase promoting complex subunit CDC23
similar to AA sequence:KEGG_Orthology:K03355
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IEA]; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0030332 - cyclin binding [Evidence IPI] [PMID 12413490]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 8895471]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP] [PMID 16481473]; GO_process: GO:0030071 - regulation of mitotic metaphase/anaphase transition [Evidence IEA]
Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities; GO_component: GO:0033203 - DNA helicase A complex [Evidence IDA] [PMID 9341218]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 8257676]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 8257676]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 9341218]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 8257676]
similar to AA sequence:KEGG_Orthology:K06063
similar to AA sequence:KEGG_Orthology:K03537
similar to AA sequence:KEGG_Orthology:K14292
Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11983179]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IMP,ISS] [PMID 11983179]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009452 - 7-methylguanosine RNA capping [Evidence IEA]; GO_process: GO:0036261 - 7-methylguanosine cap hypermethylation [Evidence IMP] [PMID 11983179]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IMP] [PMID 11983179]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 21398639]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0017126 - nucleologenesis [Evidence IMP] [PMID 15340060]; GO_process: GO:0032210 - regulation of telomere maintenance via telomerase [Evidence IMP] [PMID 18273059]; GO_process: GO:0032210 - regulation of telomere maintenance via telomerase [Evidence IMP] [PMID 18840651]
similar to AA sequence:KEGG_Orthology:K01872
Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16556230]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16556230]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004813 - alanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004813 - alanine-tRNA ligase activity [Evidence IGI,ISS] [PMID 7761427]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0006419 - alanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006419 - alanyl-tRNA aminoacylation [Evidence IGI,IMP] [PMID 7761427]; GO_process: GO:0070143 - mitochondrial alanyl-tRNA aminoacylation [Evidence IC] [PMID 16556230]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02133
Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IDA] [PMID 17082766]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IMP] [PMID 6225776]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18722382]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP,ISS] [PMID 6225776]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 2529856]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 2529856]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 6225776]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15979
similar to AA sequence:KEGG_Orthology:K05767
Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI] [PMID 9950677]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 9950677]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000920 - cytokinetic cell separation [Evidence IMP] [PMID 9442111]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032320 - positive regulation of Ras GTPase activity [Evidence IEA]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence TAS] [PMID 10652251]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11561
Probable membrane protein; involved in phosphate transport; role in the maturation of secretory proteins; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 8709965]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0006817 - phosphate ion transport [Evidence IGI,IMP,ISS] [PMID 8709965]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 19433630]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10743
Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11029655]; GO_component: GO:0032299 - ribonuclease H2 complex [Evidence IDA] [PMID 14734815]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA,IEA]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IDA,IMP] [PMID 14734815]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence ISS] [PMID 9462832]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA,IGI] [PMID 10567561]; GO_process: GO:0016070 - RNA metabolic process [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04567
Lysyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 330225]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IDA] [PMID 3888626]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IMP] [PMID 7628447]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IDA] [PMID 3888626]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IMP] [PMID 7628447]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01011
Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IEA,IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IDA,IMP] [PMID 19151091]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence ISS] [PMID 9153759]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K10395
similar to AA sequence:KEGG_Orthology:K07127
Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress; GO_component: GO:0071944 - cell periphery [Evidence IDA] [PMID 12869188]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 12869188]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24403601]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IGI,IMP] [PMID 9890948]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0043942 - negative regulation of sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 24403601]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IGI] [PMID 9890948]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:0015914 - phospholipid transport [Evidence IGI,IMP] [PMID 9890948]; GO_process: GO:0042493 - response to drug [Evidence IGI] [PMID 9890948]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IGI] [PMID 9890948]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12854
RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 8670905]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA,IMP] [PMID 8649518]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 9705931]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [Evidence IMP] [PMID 9705931]
Usp (universal stress protein) family protein
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IMP] [PMID 17173333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence ISS] [PMID 9341119]; GO_process: GO:0009436 - glyoxylate catabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence ISS] [PMID 9341119]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11922628]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 11922628]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IMP] [PMID 11922628]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0032973 - amino acid export [Evidence IGI,IMP] [PMID 15590823]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 11922628]; GO_process: GO:0015718 - monocarboxylic acid transport [Evidence IMP] [PMID 11922628]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8267570]; GO_function: GO:0015212 - cytidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 10501935]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IDA] [PMID 9092500]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015861 - cytidine transport [Evidence IDA,IMP] [PMID 10501935]; GO_process: GO:0015856 - cytosine transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0072530 - purine-containing compound transmembrane transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 8798516]; GO_function: GO:0000007 - low-affinity zinc ion transmembrane transporter activity [Evidence IMP,ISS] [PMID 8798516]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006831 - low-affinity zinc ion transport [Evidence IMP,ISS] [PMID 8798516]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0071577 - zinc ion transmembrane transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06665
similar to AA sequence:KEGG_Orthology:K14781
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10982841]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence IDA] [PMID 10982841]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IDA,TAS] [PMID 10982841]
Plasma membrane hypothetical protein; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23019326]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 8417990]
similar to AA sequence:KEGG_Orthology:K07034
Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17395151]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IMP] [PMID 12429834]; GO_process: GO:0015696 - ammonium transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEP,IMP] [PMID 12429834]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 12429834]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16938
Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress; GO_component: GO:0042764 - ascospore-type prospore [Evidence IDA] [PMID 18701287]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 9884239]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 18552279]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0072687 - meiotic spindle [Evidence IDA] [PMID 18826657]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 18826657]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 18826657]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14993234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IDA] [PMID 15901837]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 12699621]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IC] [PMID 10882120]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 14993234]; GO_process: GO:0043934 - sporulation [Evidence IDA] [PMID 18701287]
mitochondrial 54S ribosomal protein YmL32
similar to AA sequence:KEGG_Orthology:K02911
Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 16239145]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 2060626]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 2060626]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 2060626]; GO_process: GO:0006412 - translation [Evidence IEA]
hypothetical protein; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21442317]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence ISS] [PMID 7756978]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08489
Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16); GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0031303 - integral component of endosome membrane [Evidence IDA] [PMID 9565594]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 9427746]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11739407]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 10545112]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI] [PMID 18753406]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9427746]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IGI,IMP] [PMID 18753406]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006675 - mannosyl-inositol phosphorylceramide metabolic process [Evidence IGI,IMP] [PMID 18753406]; GO_process: GO:0032527 - protein exit from endoplasmic reticulum [Evidence IGI] [PMID 18753406]; GO_process: GO:0009306 - protein secretion [Evidence IMP] [PMID 22753847]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11739407]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
DNA-directed RNA polymerase I core subunit RPA135
similar to AA sequence:KEGG_Orthology:K03002
RNA polymerase I second largest subunit A135; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0032549 - ribonucleoside binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 2023944]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02608
similar to S.kluyveri pyd3 (AAK60518) beta-alanine synthase involved in pyrimidine catabolism; allele of CaO19.1369
similar to AA sequence:KEGG_Orthology:K11663
similar to AA sequence:KEGG_Orthology:K00685
Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004057 - arginyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004057 - arginyltransferase activity [Evidence IDA,IMP] [PMID 2185248]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016598 - protein arginylation [Evidence IEA]; GO_process: GO:0016598 - protein arginylation [Evidence IDA,IMP] [PMID 2185248]
Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18625724]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 18625724]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IMP] [PMID 20802492]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IEA,IEA]; GO_process: GO:0010421 - hydrogen peroxide-mediated programmed cell death [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 18625724]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 20802492]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IEA]
phospholipid:diacylglycerol acyltransferase
similar to AA sequence:KEGG_Orthology:K00679
Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 22454508]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 22454508]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IEA]; GO_function: GO:0046027 - phospholipid:diacylglycerol acyltransferase activity [Evidence IEA]; GO_function: GO:0046027 - phospholipid:diacylglycerol acyltransferase activity [Evidence IDA] [PMID 10747858]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006672 - ceramide metabolic process [Evidence IDA,IMP] [PMID 22738231]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0019915 - lipid storage [Evidence IDA,IMP] [PMID 10747858]; GO_process: GO:0019432 - triglyceride biosynthetic process [Evidence IDA,IMP] [PMID 10747858]
similar to AA sequence:KEGG_Orthology:K18670
SCF E2 ubiquitin-protein ligase catalytic subunit CDC34
similar to AA sequence:KEGG_Orthology:K02207
Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IMP] [PMID 9736614]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11080155]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8164658]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA,IMP] [PMID 7929378]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP,ISS] [PMID 2842867]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence TAS] [PMID 9346231]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 9736614]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051865 - protein autoubiquitination [Evidence IDA,IMP] [PMID 8383676]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 1848239]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]
similar to AA sequence:KEGG_Orthology:K07297
Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0001653 - peptide receptor activity [Evidence ISS] [PMID 15060275]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 15060275]
similar to AA sequence:KEGG_Orthology:K00915
Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10720331]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3311884]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000824 - inositol tetrakisphosphate 3-kinase activity [Evidence IDA] [PMID 10574768]; GO_function: GO:0000824 - inositol tetrakisphosphate 3-kinase activity [Evidence IDA] [PMID 10720331]; GO_function: GO:0000825 - inositol tetrakisphosphate 6-kinase activity [Evidence IDA] [PMID 11311242]; GO_function: GO:0000827 - inositol-1,3,4,5,6-pentakisphosphate kinase activity [Evidence IDA] [PMID 11311242]; GO_function: GO:0008440 - inositol-1,4,5-trisphosphate 3-kinase activity [Evidence IEA]; GO_function: GO:0008440 - inositol-1,4,5-trisphosphate 3-kinase activity [Evidence IMP] [PMID 10683435]; GO_function: GO:0000823 - inositol-1,4,5-trisphosphate 6-kinase activity [Evidence IEA]; GO_function: GO:0000823 - inositol-1,4,5-trisphosphate 6-kinase activity [Evidence IDA] [PMID 10574768]; GO_function: GO:0000823 - inositol-1,4,5-trisphosphate 6-kinase activity [Evidence IDA] [PMID 10720331]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0035004 - phosphatidylinositol 3-kinase activity [Evidence IDA] [PMID 16123124]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 10632874]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IDA] [PMID 10574768]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IDA] [PMID 11311242]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12828642]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 16123124]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12828642]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 10632874]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 11119723]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 2274024]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 8043104]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00750
Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008466 - glycogenin glucosyltransferase activity [Evidence IEA]; GO_function: GO:0008466 - glycogenin glucosyltransferase activity [Evidence IGI,ISS] [PMID 8524228]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI] [PMID 8524228]
similar to AA sequence:KEGG_Orthology:K02910
Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 18829863]; GO_process: GO:0006412 - translation [Evidence IEA]
Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16806052]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16806052]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_function: GO:0016832 - aldehyde-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004332 - fructose-bisphosphate aldolase activity [Evidence IEA,IEA]; GO_function: GO:0004332 - fructose-bisphosphate aldolase activity [Evidence IDA,IMP] [PMID 2647491]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 6384192]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 6384192]
Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 16314430]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16314430]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI,IMP,IPI] [PMID 17041589]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 23078654]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 16314430]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 16314430]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 23078654]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IMP] [PMID 17041589]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01719
Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004852 - uroporphyrinogen-III synthase activity [Evidence IEA,IEA]; GO_function: GO:0004852 - uroporphyrinogen-III synthase activity [Evidence IMP,ISS] [PMID 7597845]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 18042043]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IGI,IMP] [PMID 18957409]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018026 - peptidyl-lysine monomethylation [Evidence IGI,IMP] [PMID 18957409]
cyclin-dependent serine/threonine protein kinase CTK1
similar to AA sequence:KEGG_Orthology:K00916
similar to AA sequence:KEGG_Orthology:K07390
Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15456753]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IGI,IMP,ISS] [PMID 10567543]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IDA] [PMID 12730244]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI,IMP] [PMID 10567543]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence TAS] [PMID 15382238]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 10567543]
similar to AA sequence:KEGG_Orthology:K15440
tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004000 - adenosine deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043829 - tRNA-specific adenosine-37 deaminase activity [Evidence IDA] [PMID 9707437]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 9707437]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01875
Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IGI,IMP] [PMID 11747308]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence ISA] [PMID 11063681]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IGI] [PMID 11747308]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI] [PMID 11063681]; GO_process: GO:0070158 - mitochondrial seryl-tRNA aminoacylation [Evidence IGI] [PMID 11747308]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11063681]; GO_process: GO:0097056 - selenocysteinyl-tRNA(Sec) biosynthetic process [Evidence IEA]; GO_process: GO:0006434 - seryl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10592
E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 19578373]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IMP] [PMID 10395901]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 10395901]; GO_process: GO:0006997 - nucleus organization [Evidence IMP] [PMID 10395901]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 19578373]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23129771]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08052
similar to AA sequence:KEGG_Orthology:K18327
Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 12364601]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI] [PMID 12364601]
similar to AA sequence:KEGG_Orthology:K12843
Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IEA]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]
TATA-binding protein-associated factor TAF14
similar to AA sequence:KEGG_Orthology:K03140
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 12887900]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 10817755]; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 17157260]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IPI] [PMID 8668146]; GO_component: GO:0016592 - mediator complex [Evidence IPI] [PMID 7995524]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 12242279]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA,IPI] [PMID 15896708]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 7995524]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IDA] [PMID 14749386]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IC] [PMID 7995524]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 7995524]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 12887900]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 15896708]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 8668146]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10817755]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 12887900]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IC] [PMID 7995524]
similar to AA sequence:KEGG_Orthology:K03593
Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15728363]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8921898]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IDA] [PMID 17401378]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP,ISS] [PMID 8921898]; GO_function: GO:0005506 - iron ion binding [Evidence IMP,IPI] [PMID 15728363]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15728363]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 17401378]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K09117
hypothetical protein; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03650
Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11604502]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 8392589]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0070899 - mitochondrial tRNA wobble uridine modification [Evidence IMP] [PMID 15509579]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
top hit is XP_007298107.1 originated in Stereum hirsutum FP-91666 SS1
Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate; GO_component: GO:0043291 - RAVE complex [Evidence IPI] [PMID 11283612]; GO_component: GO:0043291 - RAVE complex [Evidence IPI] [PMID 11844802]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11283612]; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 15090613]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045022 - early endosome to late endosome transport [Evidence IGI,IMP] [PMID 15090613]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0043254 - regulation of protein complex assembly [Evidence IMP,IPI] [PMID 11283612]; GO_process: GO:0043254 - regulation of protein complex assembly [Evidence IGI,IMP] [PMID 11844802]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI,IMP] [PMID 11283612]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI,IMP] [PMID 11844802]
similar to AA sequence:KEGG_Orthology:K01336
Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication; GO_component: GO:0005619 - ascospore wall [Evidence IBA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence TAS] [PMID 2674123]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence TAS] [PMID 9529893]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence ISA] [PMID 3325823]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 377296]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 385314]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 2674123]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IBA,IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 385314]
Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0034044 - exomer complex [Evidence IDA] [PMID 17000877]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030140 - trans-Golgi network transport vesicle [Evidence IDA] [PMID 16498409]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI] [PMID 16498409]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 8657162]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI,IPI] [PMID 16498409]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase
similar to AA sequence:KEGG_Orthology:K03847
Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IMP] [PMID 10336995]; GO_function: GO:0052917 - dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IMP] [PMID 10336995]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 10336995]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 12460938]
peptidylprolyl isomerase family protein CPR5
similar to AA sequence:KEGG_Orthology:K03768
Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8377189]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence ISS] [PMID 8377189]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]
TATA-binding protein-associated factor TAF9
similar to AA sequence:KEGG_Orthology:K03133
Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9844639]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10747053]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9325326]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 1628805]; GO_process: GO:0070072 - vacuolar proton-transporting V-type ATPase complex assembly [Evidence IMP] [PMID 9325326]
similar to AA sequence:KEGG_Orthology:K02873
Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04718
Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 12459470]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 17686782]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12493772]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16141212]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16141212]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0017050 - D-erythro-sphingosine kinase activity [Evidence IDA] [PMID 9677363]; GO_function: GO:0003951 - NAD+ kinase activity [Evidence IEA]; GO_function: GO:0004143 - diacylglycerol kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008481 - sphinganine kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 11278643]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0046834 - lipid phosphorylation [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0007205 - protein kinase C-activating G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IDA] [PMID 9677363]
similar to AA sequence:KEGG_Orthology:K04441
Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII in osmotic shock; activates CDC28 by stimulating antisense RNA transcription; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; with Mrc1p defines novel S-phase checkpoint that prevent conflicts between DNA replication and transcription; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10817757]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10817757]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IDA] [PMID 10805732]; GO_function: GO:0004707 - MAP kinase activity [Evidence ISS] [PMID 7681220]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 24508389]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 12455951]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IMP] [PMID 23158682]; GO_process: GO:0006972 - hyperosmotic response [Evidence IMP] [PMID 7681220]; GO_process: GO:0007231 - osmosensory signaling pathway [Evidence IMP] [PMID 7681220]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12743037]; GO_process: GO:0061393 - positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress [Evidence IMP] [PMID 24508389]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 10805732]; GO_process: GO:0033262 - regulation of nuclear cell cycle DNA replication [Evidence IDA] [PMID 23178807]; GO_process: GO:0061392 - regulation of transcription from RNA polymerase II promoter in response to osmotic stress [Evidence IDA] [PMID 23178807]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046685 - response to arsenic-containing substance [Evidence IGI,IMP] [PMID 16885417]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
chromatin-remodeling histone chaperone SPT6
similar to AA sequence:KEGG_Orthology:K11292
Conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 17989219]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
dihydrolipoyllysine-residue acetyltransferase
similar to AA sequence:KEGG_Orthology:K00627
Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA,IPI] [PMID 9038189]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045254 - pyruvate dehydrogenase complex [Evidence IEA]; GO_function: GO:0004742 - dihydrolipoyllysine-residue acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004742 - dihydrolipoyllysine-residue acetyltransferase activity [Evidence IDA] [PMID 2271545]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14006
GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 8451644]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0003400 - regulation of COPII vesicle coating [Evidence IDA] [PMID 8451644]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16944
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005619 - ascospore wall [Evidence IDA] [PMID 8636217]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 1993729]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 8791410]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 18826657]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IC] [PMID 10882120]; GO_process: GO:0000281 - mitotic cytokinesis [Evidence IDA] [PMID 12636916]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 15282341]; GO_process: GO:0031107 - septin ring disassembly [Evidence IMP] [PMID 12429908]
WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21880895]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 21880895]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 21880895]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10426
Vacuolar membrane protein that is a subunit of the HOPS complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport; the homotypic vacuole fusion and vacuole protein sorting complex is also known as the HOPS complex; GO_component: GO:0030897 - HOPS complex [Evidence IPI] [PMID 10944212]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9111041]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IPI] [PMID 11062257]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IDA] [PMID 16601699]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IMP] [PMID 9184222]; GO_process: GO:0035542 - regulation of SNARE complex assembly [Evidence IDA] [PMID 18385512]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA] [PMID 18385512]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 9159129]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 10944212]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 9111041]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 12730205]
similar to AA sequence:KEGG_Orthology:K10276
JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IEA]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IDA] [PMID 16362057]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IMP] [PMID 17369256]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0070544 - histone H3-K36 demethylation [Evidence IEA]; GO_process: GO:0016577 - histone demethylation [Evidence IDA] [PMID 16362057]; GO_process: GO:0016577 - histone demethylation [Evidence IMP] [PMID 17369256]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05236
Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 19927118]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19927118]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16227579]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 19927118]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 16945917]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IGI] [PMID 19801658]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IGI] [PMID 19927118]; GO_process: GO:0032781 - positive regulation of ATPase activity [Evidence IDA,IMP] [PMID 19927118]; GO_process: GO:0051096 - positive regulation of helicase activity [Evidence IDA,IMP] [PMID 19927118]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 19927118]
similar to AA sequence:KEGG_Orthology:K08342
Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11149920]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IDA,IMP] [PMID 11038174]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11038174]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 11149920]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11149920]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0051697 - protein delipidation [Evidence IDA] [PMID 17632063]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 11149920]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 11149920]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03681
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA,IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17391830]; GO_function: GO:0030145 - manganese ion binding [Evidence IDA] [PMID 17159918]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
phosphatidylinositol-3,5-bisphosphate 5-phosphatase
Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11950935]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14528018]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 14528018]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 11950935]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 14528018]
similar to AA sequence:KEGG_Orthology:K15451
AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA,IMP] [PMID 16642040]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 16642040]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
similar to AA sequence:KEGG_Orthology:K15559
Protein involved in transcription termination by RNA polymerase II; interacts with exonuclease Rat1p and Rai1p; has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15565157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0035861 - site of double-strand break [Evidence IDA] [PMID 22355353]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 15565157]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 20818393]; GO_process: GO:0042769 - DNA damage response, detection of DNA damage [Evidence IMP] [PMID 22355353]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IGI,IMP] [PMID 15565157]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 11779788]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 10512869]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005796 - Golgi lumen [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 15504911]; GO_function: GO:0051020 - GTPase binding [Evidence IDA] [PMID 15504911]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10512869]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10562277]; GO_process: GO:0000042 - protein targeting to Golgi [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10754
Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IEA]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA] [PMID 7651383]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 8770585]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0006298 - mismatch repair [Evidence IGI] [PMID 9504910]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749598]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749599]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IGI] [PMID 7516465]
similar to AA sequence:KEGG_Orthology:K16750
similar to AA sequence:KEGG_Orthology:K12882
Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IDA] [PMID 8811086]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 22072789]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0000339 - RNA cap binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA]; GO_process: GO:0016070 - RNA metabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0045292 - mRNA cis splicing, via spliceosome [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0051028 - mRNA transport [Evidence IEA,IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA,IPI] [PMID 15753296]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 22072789]; GO_process: GO:0006810 - transport [Evidence IEA]
bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase
similar to AA sequence:KEGG_Orthology:K01656
Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p; GO_component: GO:0005950 - anthranilate synthase complex [Evidence IPI] [PMID 3881257]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IEA]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IGI] [PMID 3881257]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004425 - indole-3-glycerol-phosphate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004425 - indole-3-glycerol-phosphate synthase activity [Evidence IMP] [PMID 3881257]; GO_function: GO:0004425 - indole-3-glycerol-phosphate synthase activity [Evidence IGI,ISS] [PMID 6323449]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]; GO_process: GO:0006568 - tryptophan metabolic process [Evidence IEA]
dolichyl-phosphate beta-glucosyltransferase
similar to AA sequence:KEGG_Orthology:K00729
UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9560251]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004581 - dolichyl-phosphate beta-glucosyltransferase activity [Evidence IEA]; GO_function: GO:0004581 - dolichyl-phosphate beta-glucosyltransferase activity [Evidence IDA] [PMID 8076653]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence TAS] [PMID 8076653]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 22553352]; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 11514624]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IMP] [PMID 11792713]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IMP] [PMID 22452743]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA,IGI,IMP] [PMID 10625610]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 22553352]
similar to AA sequence:KEGG_Orthology:K11272
similar to AA sequence:KEGG_Orthology:K01487
Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008892 - guanine deaminase activity [Evidence IEA,IEA]; GO_function: GO:0008892 - guanine deaminase activity [Evidence IDA] [PMID 15565584]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence ISS] [PMID 10542258]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006147 - guanine catabolic process [Evidence IEA,IEA]; GO_process: GO:0046098 - guanine metabolic process [Evidence ISS] [PMID 10542258]
phosphogluconate dehydrogenase (decarboxylating) GND2
similar to AA sequence:KEGG_Orthology:K00033
6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 11298766]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity [Evidence IEA,IEA]; GO_function: GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity [Evidence IMP] [PMID 1328471]; GO_process: GO:0019521 - D-gluconate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA,IEA,IEA]; GO_process: GO:0009051 - pentose-phosphate shunt, oxidative branch [Evidence IGI,IMP] [PMID 1328471]
Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12970194]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IDA] [PMID 17401378]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence TAS] [PMID 12970194]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12970194]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 17401378]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K15278
Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10788474]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005462 - UDP-N-acetylglucosamine transmembrane transporter activity [Evidence IMP] [PMID 10788474]; GO_function: GO:0005338 - nucleotide-sugar transmembrane transporter activity [Evidence IEA]; GO_process: GO:0015788 - UDP-N-acetylglucosamine transport [Evidence IMP] [PMID 10788474]; GO_process: GO:0015786 - UDP-glucose transport [Evidence IGI,IMP] [PMID 18693752]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 10788474]; GO_process: GO:1901679 - nucleotide transmembrane transport [Evidence IEA]; GO_process: GO:0015780 - nucleotide-sugar transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10788474]; GO_process: GO:0006810 - transport [Evidence IEA]
Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 16275642]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 10628851]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10628851]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16314178]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19372273]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16275642]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress; GO_component: GO:0035361 - Cul8-RING ubiquitin ligase complex [Evidence IDA] [PMID 20139071]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 14988729]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 11779788]
similar to AA sequence:KEGG_Orthology:K03254
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11302750]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0002188 - translation reinitiation [Evidence IMP] [PMID 20679478]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 11591390]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IC,IPI] [PMID 11591390]
DEAH-box ATP-dependent RNA helicase PRP43
similar to AA sequence:KEGG_Orthology:K12820
RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0071014 - post-mRNA release spliceosomal complex [Evidence IMP] [PMID 11886864]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 11886864]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 17875666]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16382143]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16382143]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IGI] [PMID 19801658]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16382143]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16227579]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16382144]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 16382143]; GO_process: GO:0000390 - spliceosomal complex disassembly [Evidence IDA] [PMID 16357217]; GO_process: GO:0000390 - spliceosomal complex disassembly [Evidence IGI] [PMID 17875666]