Sugiyamaella lignohabitans strain CBS 10342 chromosome D, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Trichomonascaceae; Sugiyamaella.
Complete genome sequence and transcriptome regulation of the pentose utilising yeast Sugiyamaella lignohabitans
Submitted (25-OCT-2016) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (18-FEB-2016) Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, Vienna 1190, Austria
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP014502.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
polyprotein of L1-like non-LTR retrotransposon Zorro 3
similar to AA sequence:KEGG_Orthology:K01739
Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence IMP] [PMID 10821189]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IMP] [PMID 10821189]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 10821189]
similar to AA sequence:KEGG_Orthology:K01477
Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004037 - allantoicase activity [Evidence IEA,IEA]; GO_function: GO:0004037 - allantoicase activity [Evidence ISS] [PMID 1916277]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IEA,IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IMP] [PMID 1916277]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]
mannosyl-oligosaccharide 1,2-alpha-mannosidase
similar to AA sequence:KEGG_Orthology:K01230
Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8864657]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IDA] [PMID 12090241]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 1714453]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 8439291]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IDA] [PMID 8910350]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 8905927]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0035977 - protein deglycosylation involved in glycoprotein catabolic process [Evidence IMP] [PMID 9732283]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01438
similar to AA sequence:KEGG_Orthology:K10981
DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence TAS] [PMID 9745046]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence TAS] [PMID 9745046]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IDA] [PMID 12235149]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA,IMP] [PMID 10438542]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA] [PMID 15342630]
phosphatidylinositol-binding protein SCS2
similar to AA sequence:KEGG_Orthology:K01265
Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IGI,ISA] [PMID 8618900]; GO_function: GO:0008235 - metalloexopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0070084 - protein initiator methionine removal [Evidence IEA]; GO_process: GO:0035551 - protein initiator methionine removal involved in protein maturation [Evidence IMP] [PMID 11811952]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0005352 - alpha-glucoside:proton symporter activity [Evidence ISS] [PMID 18179544]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0000017 - alpha-glucoside transport [Evidence ISS] [PMID 18179544]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0000023 - maltose metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K04712
similar to AA sequence:KEGG_Orthology:K06661
Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 16785442]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IMP] [PMID 23240040]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17263
similar to AA sequence:KEGG_Orthology:K00927
3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004618 - phosphoglycerate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004618 - phosphoglycerate kinase activity [Evidence IDA] [PMID 6254992]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 400791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 400791]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication; GO_component: GO:0005798 - Golgi-associated vesicle [Evidence IDA] [PMID 15331637]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15331637]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 15331637]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12189143]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15331637]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15331637]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI,ISS] [PMID 12189143]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI] [PMID 15802519]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 15802519]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 12189143]
similar to AA sequence:KEGG_Orthology:K18467
Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00600
Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12700234]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 8132653]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IMP] [PMID 8132653]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IMP] [PMID 9398220]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006563 - L-serine metabolic process [Evidence IEA]; GO_process: GO:0006544 - glycine metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IMP] [PMID 8132653]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI,IMP] [PMID 9398220]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
Hsp90 cochaperone; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12525481]; GO_function: GO:0042030 - ATPase inhibitor activity [Evidence IDA] [PMID 21170051]; GO_function: GO:0030544 - Hsp70 protein binding [Evidence IDA] [PMID 12716905]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 12525481]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 9927435]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_process: GO:0006457 - protein folding [Evidence IGI,IMP] [PMID 8972212]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 22404850]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 22404850]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003785 - actin monomer binding [Evidence IDA] [PMID 15126500]; GO_function: GO:0004860 - protein kinase inhibitor activity [Evidence IMP] [PMID 15126500]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 22404850]; GO_process: GO:0001933 - negative regulation of protein phosphorylation [Evidence IMP] [PMID 15126500]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14558
Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8804409]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 8804409]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15231838]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15231838]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15231838]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8804409]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K19323
Essential hypothetical protein; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00147
Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity [Evidence IDA] [PMID 12513997]; GO_function: GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity [Evidence IGI] [PMID 2824433]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence TAS] [PMID 11084050]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IDA] [PMID 12513997]
aminophospholipid-translocating P4-type ATPase DRS2
similar to AA sequence:KEGG_Orthology:K14802
Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; subject to auto-inhibition by its C-terminal tail; mutations in human homolog ATP8B1 result in liver disease; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 10601336]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 12221123]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15090616]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 15090616]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IMP] [PMID 15249668]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 16452632]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IMP] [PMID 8633245]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 24272750]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 12631737]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 16195350]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 15249668]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 16452632]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 10601336]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8247005]
similar to AA sequence:KEGG_Orthology:K05531
Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 16034811]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 10037752]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8991513]
Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
similar to AA sequence:KEGG_Orthology:K11771
Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8016655]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA,IMP] [PMID 8159677]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3143101]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 11865042]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IMP,IPI] [PMID 14580348]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8016655]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 10198436]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 14580348]; GO_process: GO:0044109 - cellular alcohol catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0031496 - positive regulation of mating type switching [Evidence IMP] [PMID 6436497]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1339306]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3542227]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8016655]; GO_process: GO:0061412 - positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [Evidence IMP] [PMID 10549298]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0005987 - sucrose catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10848
Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 12707309]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]
phosphoribosylformylglycinamidine synthase
similar to AA sequence:KEGG_Orthology:K01952
Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004642 - phosphoribosylformylglycinamidine synthase activity [Evidence IEA,IEA]; GO_function: GO:0004642 - phosphoribosylformylglycinamidine synthase activity [Evidence IMP] [PMID 9331966]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IC] [PMID 9331966]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 1743513]
similar to AA sequence:KEGG_Orthology:K08870
Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 16569665]; GO_function: GO:0003785 - actin monomer binding [Evidence IDA] [PMID 9700161]; GO_process: GO:0044396 - actin cortical patch organization [Evidence IMP] [PMID 16569665]; GO_process: GO:0030042 - actin filament depolymerization [Evidence IDA] [PMID 16569665]; GO_process: GO:0007015 - actin filament organization [Evidence IDA,IMP] [PMID 16569665]; GO_process: GO:0051014 - actin filament severing [Evidence IDA,IMP] [PMID 16569665]; GO_process: GO:0030837 - negative regulation of actin filament polymerization [Evidence IEA]; GO_process: GO:0042989 - sequestering of actin monomers [Evidence IDA] [PMID 9700161]
similar to AA sequence:KEGG_Orthology:K15100
Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 7908717]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005469 - succinate:fumarate antiporter activity [Evidence IDA] [PMID 9395087]; GO_process: GO:0015741 - fumarate transport [Evidence IDA] [PMID 9395087]; GO_process: GO:0015744 - succinate transport [Evidence IDA] [PMID 9395087]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11763
Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 11931764]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0003682 - chromatin binding [Evidence IPI] [PMID 11931764]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA,IDA] [PMID 12183366]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IDA] [PMID 11931764]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 11931764]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 11931764]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11931764]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22310663]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22342701]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22405070]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22310663]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22342701]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22405070]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IGI] [PMID 22310663]; GO_process: GO:0097250 - mitochondrial respiratory chain supercomplex assembly [Evidence IMP] [PMID 22342701]; GO_process: GO:0097250 - mitochondrial respiratory chain supercomplex assembly [Evidence IMP] [PMID 22405070]
similar to AA sequence:KEGG_Orthology:K00942
Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004385 - guanylate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004385 - guanylate kinase activity [Evidence IDA] [PMID 1334480]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046037 - GMP metabolic process [Evidence TAS] [PMID 11035032]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08502
Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12869188]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 10848624]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12869188]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 17803462]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 10848624]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IGI] [PMID 10848624]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI] [PMID 16126894]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0045717 - negative regulation of fatty acid biosynthetic process [Evidence IDA,IGI,IMP] [PMID 17803462]; GO_process: GO:1901352 - negative regulation of phosphatidylglycerol biosynthetic process [Evidence IGI] [PMID 12869188]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IGI] [PMID 16262726]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:2001247 - positive regulation of phosphatidylcholine biosynthetic process [Evidence IGI] [PMID 12869188]; GO_process: GO:0006810 - transport [Evidence IEA]
Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16204239]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0032217 - riboflavin transporter activity [Evidence IGI] [PMID 16204239]; GO_process: GO:0032218 - riboflavin transport [Evidence IGI] [PMID 16204239]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 1535043]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8319300]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEP] [PMID 10206703]; GO_process: GO:0071361 - cellular response to ethanol [Evidence IEP] [PMID 10206703]; GO_process: GO:0034605 - cellular response to heat [Evidence IEP] [PMID 10206703]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IEP] [PMID 10206703]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IEP] [PMID 10206703]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0032780 - negative regulation of ATPase activity [Evidence IMP] [PMID 9250391]; GO_process: GO:0006950 - response to stress [Evidence IEA]
bifunctional N-glycosylase/AP lyase NTG2
similar to AA sequence:KEGG_Orthology:K10773
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10471279]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19029246]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 14500818]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000703 - oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [Evidence IDA,ISS] [PMID 9020769]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IDA] [PMID 14500818]; GO_process: GO:0006285 - base-excision repair, AP site formation [Evidence IDA] [PMID 9826748]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
CCR4-NOT core exoribonuclease subunit CCR4
similar to AA sequence:KEGG_Orthology:K12603
similar to AA sequence:KEGG_Orthology:K03386
Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; deletion causes mutator phenotype; protein abundance increases and forms cytoplasmic foci during DNA replication stress; chaperone activity is essential for growth under zinc deficiency; required for telomere length maintenance; TSA1 has a paralog, TSA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10681558]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8344960]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18271751]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 18271751]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA,IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IDA] [PMID 17210445]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 18271751]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP] [PMID 7961686]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP] [PMID 9799566]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 16251355]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IGI] [PMID 19851444]; GO_process: GO:0042262 - DNA protection [Evidence IMP] [PMID 19543365]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 8344960]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IMP] [PMID 9799566]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 18271751]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA,IMP] [PMID 8344960]; GO_process: GO:0061077 - chaperone-mediated protein folding [Evidence IMP] [PMID 24022485]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 16251355]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 20729566]; GO_process: GO:0033194 - response to hydroperoxide [Evidence IMP] [PMID 15210711]
Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9372916]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 9372916]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 19037259]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033674 - positive regulation of kinase activity [Evidence IGI] [PMID 11950935]; GO_process: GO:0010513 - positive regulation of phosphatidylinositol biosynthetic process [Evidence IGI] [PMID 11950935]
similar to AA sequence:KEGG_Orthology:K03114
Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembly in vitro; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11014808]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11014808]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 11014808]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0004857 - enzyme inhibitor activity [Evidence IDA] [PMID 19962315]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 19776351]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IDA] [PMID 19962315]; GO_process: GO:0032185 - septin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 18791237]
similar to AA sequence:KEGG_Orthology:K14831
Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 17914457]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17914457]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 17914457]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 12455995]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IGI,IPI] [PMID 7498791]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 8227021]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 8300560]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8013906]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI,IMP,IPI] [PMID 17914457]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IGI] [PMID 14517318]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03644
Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0016992 - lipoate synthase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0016992 - lipoate synthase activity [Evidence ISA] [PMID 8349643]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009107 - lipoate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IMP] [PMID 19570983]
similar to AA sequence:KEGG_Orthology:K01476
Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004053 - arginase activity [Evidence IEA,IEA]; GO_function: GO:0004053 - arginase activity [Evidence IMP] [PMID 14582193]; GO_function: GO:0004053 - arginase activity [Evidence IDA] [PMID 2404017]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016813 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IDA] [PMID 1939179]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0090369 - ornithine carbamoyltransferase inhibitor activity [Evidence IDA,IMP] [PMID 12679340]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 1939179]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IMP] [PMID 14582193]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IDA] [PMID 2404017]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA,IEA]; GO_process: GO:0090368 - regulation of ornithine metabolic process [Evidence IDA,IMP] [PMID 12679340]; GO_process: GO:0000050 - urea cycle [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11484
Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0032041 - NAD-dependent histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0097372 - NAD-dependent histone deacetylase activity (H3-K18 specific) [Evidence IEA]; GO_function: GO:0046969 - NAD-dependent histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0046970 - NAD-dependent histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IDA] [PMID 10535926]; GO_function: GO:0031078 - histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0032129 - histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0034739 - histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0070932 - histone H3 deacetylation [Evidence IEA]; GO_process: GO:0070933 - histone H4 deacetylation [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 10535926]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17706600]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IPI] [PMID 19823668]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18159
similar to AA sequence:KEGG_Orthology:K10084
Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 19279007]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0030246 - carbohydrate binding [Evidence IMP,ISS] [PMID 11375935]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 19124653]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11254655]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11375935]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02987
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0006412 - translation [Evidence IEA]
Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage; GO_component: GO:0000262 - mitochondrial chromosome [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IEA,IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10209025]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA,IMP] [PMID 22948312]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 10209025]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 22027892]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IEA]; GO_process: GO:0000725 - recombinational repair [Evidence IMP] [PMID 22027892]
Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22342701]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22310663]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22342701]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IGI] [PMID 22310663]
similar to AA sequence:KEGG_Orthology:K02358
Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence ISS] [PMID 6353412]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IGI] [PMID 15695360]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 3301847]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IGI] [PMID 15695360]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IDA] [PMID 3301847]; GO_function: GO:0003746 - translation elongation factor activity [Evidence ISS] [PMID 6353412]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 15695360]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 16777356]; GO_process: GO:0070125 - mitochondrial translational elongation [Evidence ISA] [PMID 3905388]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K13289
Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
protein phosphatase 2A structural subunit TPD3
similar to AA sequence:KEGG_Orthology:K03456
Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12388751]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12388751]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12388751]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12388751]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12388751]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12388751]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,IMP] [PMID 17550305]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IMP] [PMID 9001215]; GO_process: GO:0006417 - regulation of translation [Evidence IMP] [PMID 10329624]
NADH dehydrogenase (ubiquinone) Fe-S protein 8
similar to AA sequence:KEGG_Orthology:K03941
similar to AA sequence:KEGG_Orthology:K09142
similar to AA sequence:KEGG_Orthology:K15119
Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate transporter; involved in mitochondrial iron homeostasis and in activating mitochondrial Sod2p by facilitating insertion of an essential manganese cofactor; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12890866]; GO_function: GO:0016530 - metallochaperone activity [Evidence IMP] [PMID 12890866]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IDA] [PMID 24184947]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 12890866]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07204
Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; GO_component: GO:0031931 - TORC1 complex [Evidence IEA]; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16394584]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 17560372]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16394584]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0031929 - TOR signaling [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 12408816]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]
similar to AA sequence:KEGG_Orthology:K14798
Component of the GSE complex; GSE is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature; GO_component: GO:0034448 - EGO complex [Evidence IDA] [PMID 16732272]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16888326]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 16732272]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16888326]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16738661]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 15611164]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IGI,IMP] [PMID 16888326]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14209
Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11274162]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015186 - L-glutamine transmembrane transporter activity [Evidence IGI,IMP] [PMID 11274162]; GO_function: GO:0015188 - L-isoleucine transmembrane transporter activity [Evidence IGI,IMP] [PMID 11274162]; GO_function: GO:0005302 - L-tyrosine transmembrane transporter activity [Evidence IGI,IMP] [PMID 11274162]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0032974 - amino acid transmembrane export from vacuole [Evidence IGI,IMP] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
DNA-directed RNA polymerase III subunit RPC25
similar to AA sequence:KEGG_Orthology:K03022
RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 15612920]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 8065349]; GO_process: GO:0006384 - transcription initiation from RNA polymerase III promoter [Evidence IMP] [PMID 15612920]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
succinate dehydrogenase flavoprotein subunit SDH1
similar to AA sequence:KEGG_Orthology:K00234
Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; SDH1 has a paralog, YJL045W, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IDA] [PMID 1939170]; GO_component: GO:0005749 - mitochondrial respiratory chain complex II [Evidence IDA] [PMID 9822678]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 2826438]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IDA] [PMID 18279395]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IMP] [PMID 1939170]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IDA] [PMID 13445213]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IGI,IMP] [PMID 16232921]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IMP] [PMID 197391]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IMP] [PMID 9730279]; GO_process: GO:0045333 - cellular respiration [Evidence IGI,IMP] [PMID 16232921]; GO_process: GO:0045333 - cellular respiration [Evidence IGI,IMP] [PMID 9730279]; GO_process: GO:0022900 - electron transport chain [Evidence IEA]; GO_process: GO:0006121 - mitochondrial electron transport, succinate to ubiquinone [Evidence IDA] [PMID 2826438]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IC] [PMID 13445213]
similar to AA sequence:KEGG_Orthology:K10732
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IGI,IMP] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12768207]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12730134]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12768207]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
proteasome regulatory particle base subunit RPT1
similar to AA sequence:KEGG_Orthology:K03061
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7754704]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0045732 - positive regulation of protein catabolic process [Evidence IDA] [PMID 15135049]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 15135049]
similar to AA sequence:KEGG_Orthology:K18328
RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1850323]; GO_function: GO:0008419 - RNA lariat debranching enzyme activity [Evidence IDA,IMP] [PMID 1850323]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_process: GO:0006401 - RNA catabolic process [Evidence IDA,IMP] [PMID 1850323]; GO_process: GO:0006397 - mRNA processing [Evidence IEA,IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 24919400]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0016074 - snoRNA metabolic process [Evidence IMP] [PMID 9740128]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence IMP] [PMID 10652222]
similar to AA sequence:KEGG_Orthology:K14782
Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 15590835]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00326
Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 8001120]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 8001120]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IEA]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IDA] [PMID 8001120]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11420140]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 10622712]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17757
NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0047453 - ATP-dependent NAD(P)H-hydrate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0047453 - ATP-dependent NAD(P)H-hydrate dehydratase activity [Evidence IDA] [PMID 21994945]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0046496 - nicotinamide nucleotide metabolic process [Evidence IEA]; GO_process: GO:0046496 - nicotinamide nucleotide metabolic process [Evidence IDA] [PMID 21994945]
similar to AA sequence:KEGG_Orthology:K09104
Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 9407032]; GO_component: GO:0000776 - kinetochore [Evidence IPI] [PMID 11070082]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IMP] [PMID 20935143]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 8665859]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7891681]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9894911]; GO_function: GO:0001078 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Evidence IDA] [PMID 15302821]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 7891681]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IDA] [PMID 12820973]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 12820973]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 20935143]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 11222754]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 2057354]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 2249662]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 9407032]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 15111622]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 21131275]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 2249662]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 7891681]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 2057354]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 2185892]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 2188087]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 9584087]; GO_process: GO:0061427 - negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter [Evidence IMP] [PMID 15302821]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10921921]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22696683]; GO_process: GO:1900375 - positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17351075]; GO_process: GO:1900375 - positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 20935143]; GO_process: GO:1900478 - positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7601277]; GO_process: GO:1900478 - positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7891681]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22696683]; GO_process: GO:0061432 - regulation of transcription from RNA polymerase II promoter in response to methionine [Evidence IMP] [PMID 7891681]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06676
Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000796 - condensin complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IPI,ISS] [PMID 10749931]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IPI,ISS] [PMID 7698648]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10749931]; GO_function: GO:0003682 - chromatin binding [Evidence IGI] [PMID 11864994]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IMP] [PMID 24062159]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IGI,IMP] [PMID 10749931]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 7698648]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 10749931]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
similar to AA sequence:KEGG_Orthology:K03869
Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IDA] [PMID 16675952]; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IMP] [PMID 17296727]; GO_component: GO:0031461 - cullin-RING ubiquitin ligase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 12676951]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17296727]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IC] [PMID 12676951]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence ISS] [PMID 9531531]
similar to AA sequence:KEGG_Orthology:K02962
Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IBA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 3915776]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IBA]
chromatin-binding transcription regulator ADA2
similar to AA sequence:KEGG_Orthology:K11314
similar to AA sequence:KEGG_Orthology:K14397
similar to AA sequence:KEGG_Orthology:K14557
Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Putative paralog of ATR1; but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13303
similar to AA sequence:KEGG_Orthology:K02515
mitochondrial 37S ribosomal protein NAM9
Mitochondrial ribosomal component of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
similar to AA sequence:KEGG_Orthology:K17261
CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus, in physically and genetically separate activity, binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8552082]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 19201756]; GO_function: GO:0008179 - adenylate cyclase binding [Evidence IDA] [PMID 2184942]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IMP] [PMID 9774417]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IDA,IMP] [PMID 19201756]; GO_process: GO:0051014 - actin filament severing [Evidence IDA] [PMID 23135996]; GO_process: GO:0000902 - cell morphogenesis [Evidence IEA]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11672
Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; GO_component: GO:0031011 - Ino80 complex [Evidence IEA]; GO_component: GO:0031011 - Ino80 complex [Evidence IDA,IMP] [PMID 12887900]; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 15525518]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10923024]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 12887900]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 15525518]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 12887900]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14835
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9767141]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IDA] [PMID 10445884]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 17567576]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IMP] [PMID 22760636]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10445884]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0002127 - wobble base cytosine methylation [Evidence IMP] [PMID 22760636]
similar to AA sequence:KEGG_Orthology:K03256
Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9851972]; GO_component: GO:0031515 - tRNA (m1A) methyltransferase complex [Evidence IDA,IPI] [PMID 10779558]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016429 - tRNA (adenine-N1-)-methyltransferase activity [Evidence IDA] [PMID 10779558]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10779558]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA,IMP] [PMID 16321977]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006479 - protein methylation [Evidence IEA]; GO_process: GO:0006451 - translational readthrough [Evidence IGI] [PMID 16321977]
similar to AA sequence:KEGG_Orthology:K01738
Putative cysteine synthase; localized to the mitochondrial outer membrane; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IEA]
phosphoprotein phosphatase 2A catalytic subunit PPH21
similar to AA sequence:KEGG_Orthology:K04382
Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IMP] [PMID 2176150]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 12518319]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 9001215]; GO_process: GO:0007117 - budding cell bud growth [Evidence TAS] [PMID 9001215]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IPI] [PMID 9001215]; GO_process: GO:0006470 - protein dephosphorylation [Evidence TAS] [PMID 9001215]; GO_process: GO:0006417 - regulation of translation [Evidence IPI] [PMID 10329624]
similar to AA sequence:KEGG_Orthology:K03126
Subunit (61/68 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 10751405]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9674426]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12600943]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA,IMP] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10751405]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11561287]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12582246]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12194
One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9606181]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 15086794]; GO_process: GO:0071454 - cellular response to anoxia [Evidence IMP] [PMID 20402793]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 9606181]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
similar to AA sequence:KEGG_Orthology:K08490
cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 11001058]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 11959998]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 9725919]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 1400588]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11001058]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11959998]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 9545229]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 7596416]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11001046]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IMP] [PMID 9545229]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
mitochondrial 37S ribosomal protein RSM24
similar to AA sequence:KEGG_Orthology:K17413
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
mitochondrial 37S ribosomal protein RSM7
similar to AA sequence:KEGG_Orthology:K02992
Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
Chromatin associated high mobility group (HMG) family member; involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8969238]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16612005]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 17646381]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12374750]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 22553361]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 15507436]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 16533046]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 15507436]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 16533046]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 15507436]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 16533046]; GO_process: GO:0060962 - regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17875934]; GO_process: GO:0060962 - regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 18187511]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IDA] [PMID 18451108]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IGI] [PMID 12374750]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 16612005]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11155
Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10672016]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034736 - cholesterol O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034737 - ergosterol O-acyltransferase activity [Evidence IGI,IMP] [PMID 10672016]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0008204 - ergosterol metabolic process [Evidence IGI,IMP] [PMID 10672016]
similar to AA sequence:KEGG_Orthology:K10082
kinase-regulated stress-responsive transcription factor SKN7
similar to AA sequence:KEGG_Orthology:K15859
similar to AA sequence:KEGG_Orthology:K08286
chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
similar to AA sequence:KEGG_Orthology:K03842
Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IPI] [PMID 15044395]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 2182636]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0019187 - beta-1,4-mannosyltransferase activity [Evidence IDA] [PMID 6368538]; GO_function: GO:0004578 - chitobiosyldiphosphodolichol beta-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IMP] [PMID 7037780]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 6369318]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02183
Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 1639847]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 1639847]; GO_component: GO:0005823 - central plaque of spindle pole body [Evidence IDA] [PMID 8601600]; GO_component: GO:0005823 - central plaque of spindle pole body [Evidence IDA] [PMID 8886974]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 1639847]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 1639847]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 3533275]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 8461293]; GO_function: GO:0048306 - calcium-dependent protein binding [Evidence IDA] [PMID 1321337]; GO_function: GO:0048306 - calcium-dependent protein binding [Evidence IPI] [PMID 9756868]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10749918]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 7925277]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 8247006]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 8294515]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9450989]; GO_process: GO:0006607 - NLS-bearing protein import into nucleus [Evidence IMP] [PMID 17878171]; GO_process: GO:0007114 - cell budding [Evidence IMP] [PMID 8310294]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IMP] [PMID 8310294]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 12836012]; GO_process: GO:0016237 - microautophagy [Evidence IMP] [PMID 16055436]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IGI,IMP] [PMID 12079494]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 7988551]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 9450989]; GO_process: GO:0051300 - spindle pole body organization [Evidence IMP] [PMID 1469052]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP] [PMID 17878171]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 9859992]
similar to AA sequence:KEGG_Orthology:K07119
SCF ubiquitin ligase complex subunit HRT3
similar to AA sequence:KEGG_Orthology:K10295
Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 10582239]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 14747994]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IPI] [PMID 17141224]; GO_function: GO:0030674 - protein binding, bridging [Evidence ISA] [PMID 10582239]; GO_function: GO:0030674 - protein binding, bridging [Evidence ISA] [PMID 9635407]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISA] [PMID 10582239]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISA] [PMID 9635407]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IGI,ISA] [PMID 10582239]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence ISA] [PMID 9635407]; GO_process: GO:0071406 - cellular response to methylmercury [Evidence IMP] [PMID 17141224]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 23673619]; GO_component: GO:0051286 - cell tip [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9214378]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 2647769]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9214378]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 2647769]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9214378]; GO_component: GO:0000133 - polarisome [Evidence IDA] [PMID 9632790]; GO_function: GO:0005078 - MAP-kinase scaffold activity [Evidence IDA,IMP] [PMID 12361575]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 8909546]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 10866679]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8013906]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8909546]; GO_process: GO:0036267 - invasive filamentous growth [Evidence IGI] [PMID 9443897]; GO_process: GO:0031382 - mating projection assembly [Evidence IGI] [PMID 9443897]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IGI,IMP] [PMID 12857882]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IMP] [PMID 19633059]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9443897]; GO_process: GO:0008360 - regulation of cell shape [Evidence IEA]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 14734532]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10085294]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 11740491]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 12857882]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 16166638]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 8909546]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 9571251]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 9632790]; GO_process: GO:0031385 - regulation of termination of mating projection growth [Evidence IMP] [PMID 14734532]
similar to AA sequence:KEGG_Orthology:K01426
Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00851
Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0046316 - gluconokinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046177 - D-gluconate catabolic process [Evidence IEA]; GO_process: GO:0019521 - D-gluconate metabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
mitochondrial 54S ribosomal protein YmL15
similar to AA sequence:KEGG_Orthology:K17437
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
similar to AA sequence:KEGG_Orthology:K14779
RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9154839]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9154839]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9154839]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9154839]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0048254 - snoRNA localization [Evidence IMP] [PMID 18833290]
similar to AA sequence:KEGG_Orthology:K02140
Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0000276 - mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO_component: GO:0000276 - mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IMP,IPI,ISS] [PMID 10336613]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045263 - proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP,IPI] [PMID 9857174]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 10336613]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,IPI] [PMID 9857174]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 19528297]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 17761666]; GO_process: GO:0035786 - protein complex oligomerization [Evidence IMP] [PMID 16551625]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10077572]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IEA]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IDA] [PMID 10600176]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 10077572]
similar to AA sequence:KEGG_Orthology:K05542
Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IDA] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12863
Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14573466]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006972 - hyperosmotic response [Evidence IMP,IPI] [PMID 14685261]; GO_process: GO:0000200 - inactivation of MAPK activity involved in cell wall organization or biogenesis [Evidence IMP,IPI] [PMID 22570491]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IDA] [PMID 14685261]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 14573466]
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; GO_component: GO:0033186 - CAF-1 complex [Evidence IDA] [PMID 9030687]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 11782447]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9030688]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 16503640]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IDA] [PMID 9030687]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IMP] [PMID 9030688]
similar to AA sequence:KEGG_Orthology:K01301
hypothetical protein involved in vacuolar protein sorting; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01802
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IPI] [PMID 15643056]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643056]; GO_function: GO:0016018 - cyclosporin A binding [Evidence IMP] [PMID 7515500]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 2687115]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 15643056]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 11641409]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 12242280]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045836 - positive regulation of meiosis [Evidence IGI,IMP] [PMID 15643056]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12471
Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0030125 - clathrin vesicle coat [Evidence IDA] [PMID 12483220]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12967568]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IDA] [PMID 12967568]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 14630930]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 14630930]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12483220]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 12483220]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence ISS] [PMID 10449404]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 12967568]; GO_process: GO:0007015 - actin filament organization [Evidence ISS] [PMID 10449404]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI] [PMID 20658963]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 15107463]; GO_process: GO:0071985 - multivesicular body sorting pathway [Evidence IMP] [PMID 12967568]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Highly-acidic RWD domain-containing hypothetical protein; cytoplasmic; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 19448108]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]
similar to AA sequence:KEGG_Orthology:K02212
Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0097373 - MCM core complex [Evidence IDA] [PMID 13679365]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10559985]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10559985]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15723534]; GO_function: GO:1990163 - ATP-dependent four-way junction helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 15723534]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI] [PMID 2044962]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 13679365]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 15723534]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 2044962]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 8917313]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8917313]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 12637560]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8917313]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 12637560]; GO_process: GO:0006412 - translation [Evidence IEA]
RNA polymerase I upstream activation factor complex subunit Rrn5
Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10757808]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10757808]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA,IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IGI,IMP] [PMID 18694928]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IDA] [PMID 23919454]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006037 - cell wall chitin metabolic process [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0071555 - cell wall organization [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
DNA-binding transcription repressor ASH1
similar to AA sequence:KEGG_Orthology:K14396
Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10764794]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA] [PMID 10764794]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IGI] [PMID 10764794]
mitochondrial 37S ribosomal protein RSM22
Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL1 has a paralog, KEL2, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 23673619]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9786949]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9786949]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9786949]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000755 - cytogamy [Evidence IGI,IMP,IPI] [PMID 9786949]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IMP,IPI] [PMID 12234925]; GO_process: GO:0008360 - regulation of cell shape [Evidence IMP] [PMID 9786949]
zinc-coordinating transcription factor SFP1
similar to AA sequence:KEGG_Orthology:K19487
Putative ATP-dependent permease of the ABC transporter family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence ISS] [PMID 9020838]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9020838]; GO_process: GO:0006810 - transport [Evidence IEA]
Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11553703]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IDA] [PMID 16687570]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 18948116]; GO_process: GO:0072318 - clathrin coat disassembly [Evidence IMP] [PMID 11146663]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 11553703]; GO_process: GO:0032781 - positive regulation of ATPase activity [Evidence IDA] [PMID 16687570]
similar to AA sequence:KEGG_Orthology:K03141
Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 15909982]; GO_function: GO:0010314 - phosphatidylinositol-5-phosphate binding [Evidence IDA] [PMID 15909982]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 7891722]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IMP] [PMID 12015980]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10792726]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 16413483]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI,IPI] [PMID 11054575]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 9488429]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IPI] [PMID 11054575]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IMP] [PMID 11929994]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20368619]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 15456889]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 16607023]
ATP-binding cassette long-chain fatty acid transporter PXA1
similar to AA sequence:KEGG_Orthology:K15628
Subunit of a heterodimeric peroxisomal ABC transport complex; required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; complex also includes Pxa2p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 8670886]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IMP,ISS] [PMID 8670886]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015908 - fatty acid transport [Evidence IMP] [PMID 8670886]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 23204190]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 23204190]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015079 - potassium ion transmembrane transporter activity [Evidence IDA] [PMID 23204190]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IDA] [PMID 23204190]
similar to AA sequence:KEGG_Orthology:K00728
Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals; GO_component: GO:0097586 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex [Evidence IPI] [PMID 12551906]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IDA,IMP] [PMID 21956107]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IMP,ISS] [PMID 8585318]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IMP,ISS] [PMID 8585318]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IMP] [PMID 18182384]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IMP] [PMID 21231968]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IGI] [PMID 21231968]
similar to AA sequence:KEGG_Orthology:K10842
Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 10681587]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17287526]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 15590673]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 17287526]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 17287526]
similar to AA sequence:KEGG_Orthology:K01495
GTP-cyclohydrolase I; catalyzes the first step in the folic acid biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003934 - GTP cyclohydrolase I activity [Evidence IEA,IEA]; GO_function: GO:0003934 - GTP cyclohydrolase I activity [Evidence IMP] [PMID 8573145]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0035998 - 7,8-dihydroneopterin 3'-triphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IMP] [PMID 8573145]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]
Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11489916]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K13524
Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 23740823]; GO_function: GO:0003867 - 4-aminobutyrate transaminase activity [Evidence IEA,IEA]; GO_function: GO:0003867 - 4-aminobutyrate transaminase activity [Evidence IMP] [PMID 3888627]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0009448 - gamma-aminobutyric acid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11423
similar to AA sequence:KEGG_Orthology:K15437
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11726524]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15710377]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IMP,IPI] [PMID 9659920]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 11069915]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IMP,IPI] [PMID 11726524]; GO_process: GO:0051351 - positive regulation of ligase activity [Evidence IDA] [PMID 11069915]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IMP] [PMID 9659920]
similar to AA sequence:KEGG_Orthology:K03143
Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IPI] [PMID 10681587]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 10506223]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
mitochondrial 54S ribosomal protein YmL37
similar to AA sequence:KEGG_Orthology:K17435
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 2060626]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 2060626]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 2060626]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05310
Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 10329735]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10329735]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 15452134]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IMP] [PMID 10329735]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 10329735]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 15452134]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13124
Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 11585915]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
mitochondrial 54S ribosomal protein YmL41
similar to AA sequence:KEGG_Orthology:K02892
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 1544898]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 1544898]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1544898]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03854
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 7975899]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 7975899]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence ISS] [PMID 7975899]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10366597]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 23333351]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IPI] [PMID 7719850]; GO_process: GO:0030042 - actin filament depolymerization [Evidence IGI,IPI] [PMID 10366597]; GO_process: GO:0051016 - barbed-end actin filament capping [Evidence IMP] [PMID 23333351]; GO_process: GO:0006970 - response to osmotic stress [Evidence TAS] [PMID 10652251]
Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
similar to AA sequence:KEGG_Orthology:K08192
similar to AA sequence:KEGG_Orthology:K14549
Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 18216280]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0048255 - mRNA stabilization [Evidence IEA]; GO_process: GO:0048255 - mRNA stabilization [Evidence IMP] [PMID 18216280]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 18216280]
similar to AA sequence:KEGG_Orthology:K15456
Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 15772087]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016049 - cell growth [Evidence IPI] [PMID 12139626]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 15772087]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06948
Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12808030]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISA] [PMID 12808030]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI,IMP] [PMID 12808030]
acireductone dioxygenase (Ni2+-requiring)
similar to AA sequence:KEGG_Orthology:K08967
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010308 - acireductone dioxygenase (Ni2+-requiring) activity [Evidence IMP] [PMID 15938715]; GO_function: GO:0010309 - acireductone dioxygenase [iron(II)-requiring] activity [Evidence IEA,IEA,IEA]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IGI,IMP,ISS] [PMID 15938715]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; GO_component: GO:0000938 - GARP complex [Evidence IPI] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence TAS] [PMID 11689439]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 10637310]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IDA] [PMID 12686613]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13108
Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p; GO_component: GO:0070274 - RES complex [Evidence IDA] [PMID 15565172]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 15565172]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 15565172]; GO_process: GO:0051237 - maintenance of RNA location [Evidence IMP] [PMID 16162818]
similar to AA sequence:KEGG_Orthology:K14776
DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 16209945]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 16209945]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16209945]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08073
DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11278831]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 15222769]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 15222769]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046403 - polynucleotide 3'-phosphatase activity [Evidence IEA]; GO_function: GO:0046403 - polynucleotide 3'-phosphatase activity [Evidence IDA] [PMID 11278831]; GO_function: GO:0046403 - polynucleotide 3'-phosphatase activity [Evidence IMP] [PMID 15222769]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI,IMP] [PMID 11585902]; GO_process: GO:0098506 - polynucleotide 3' dephosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02940
Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01551
Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0043529 - GET complex [Evidence IEA]; GO_component: GO:0043529 - GET complex [Evidence IPI] [PMID 16269340]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12680698]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 18261907]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 18261907]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IDA] [PMID 20850366]; GO_process: GO:0045048 - protein insertion into ER membrane [Evidence IEA]; GO_process: GO:0045048 - protein insertion into ER membrane [Evidence IMP] [PMID 18724936]; GO_process: GO:0046685 - response to arsenic-containing substance [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 12680698]; GO_process: GO:0010038 - response to metal ion [Evidence IMP] [PMID 12680698]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IGI,IMP] [PMID 16269340]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18468
Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22593205]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03351
similar to AA sequence:KEGG_Orthology:K15027
hypothetical protein that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 10093218]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05291
Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 15939668]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15075373]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15939668]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IMP,ISS] [PMID 11483512]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP,ISS] [PMID 11483512]
mitochondrial 54S ribosomal protein MRPL1
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01835
Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8385141]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_function: GO:0016868 - intramolecular transferase activity, phosphotransferases [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IEA]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IMP] [PMID 13887540]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IMP] [PMID 2138705]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IGI,IMP,ISS] [PMID 8119301]; GO_process: GO:0006011 - UDP-glucose metabolic process [Evidence IGI] [PMID 9252577]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 10681519]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI,IMP] [PMID 15252028]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IMP] [PMID 15164360]; GO_process: GO:0019388 - galactose catabolic process [Evidence IMP] [PMID 13887540]; GO_process: GO:0019388 - galactose catabolic process [Evidence IMP] [PMID 14264884]; GO_process: GO:0019388 - galactose catabolic process [Evidence IGI,IMP] [PMID 8119301]; GO_process: GO:0019255 - glucose 1-phosphate metabolic process [Evidence IMP] [PMID 10681519]; GO_process: GO:0019255 - glucose 1-phosphate metabolic process [Evidence IGI,IMP,ISS] [PMID 8119301]; GO_process: GO:0051156 - glucose 6-phosphate metabolic process [Evidence ISS] [PMID 8119301]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI] [PMID 9252577]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IGI] [PMID 9252577]
similar to AA sequence:KEGG_Orthology:K10885
Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IEA]; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IDA] [PMID 8754818]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence TAS] [PMID 10367891]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence TAS] [PMID 12080091]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16166630]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12975323]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence TAS] [PMID 10367891]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 17656141]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 11553718]; GO_process: GO:0006342 - chromatin silencing [Evidence IDA,IMP] [PMID 9501103]; GO_process: GO:0007535 - donor selection [Evidence IDA,IMP] [PMID 16166630]; GO_process: GO:0007535 - donor selection [Evidence IGI,IMP] [PMID 16809780]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 11016833]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IEA]; GO_process: GO:0034502 - protein localization to chromosome [Evidence IGI] [PMID 18716325]; GO_process: GO:0000723 - telomere maintenance [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 10818099]
UDP-glucose:hexose-1-phosphate uridylyltransferase
similar to AA sequence:KEGG_Orthology:K00965
Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10993714]; GO_function: GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity [Evidence IMP] [PMID 14158615]; GO_function: GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity [Evidence IDA] [PMID 387754]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IMP] [PMID 14158615]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IDA] [PMID 387754]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K10735
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IGI,IMP] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12768207]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12730134]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12768207]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
similar to AA sequence:KEGG_Orthology:K10415
Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex; GO_component: GO:0036396 - MIS complex [Evidence IDA,IPI] [PMID 22685417]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 22685417]; GO_process: GO:0080009 - mRNA methylation [Evidence IGI,IMP] [PMID 22685417]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 22685417]; GO_process: GO:2000221 - negative regulation of pseudohyphal growth [Evidence IMP] [PMID 22685417]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IGI] [PMID 11238403]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IMP] [PMID 9504908]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
3-deoxy-7-phosphoheptulonate synthase ARO3
similar to AA sequence:KEGG_Orthology:K01626
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IDA] [PMID 2880280]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16576
similar to AA sequence:KEGG_Orthology:K14791
Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 15588312]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IMP,ISS] [PMID 15588312]
1-phosphatidylinositol-4-phosphate 5-kinase
similar to AA sequence:KEGG_Orthology:K00889
Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
glycylpeptide N-tetradecanoyltransferase NMT1
similar to AA sequence:KEGG_Orthology:K00671
N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1544917]; GO_function: GO:0004379 - glycylpeptide N-tetradecanoyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004379 - glycylpeptide N-tetradecanoyltransferase activity [Evidence IMP] [PMID 8955162]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0018008 - N-terminal peptidyl-glycine N-myristoylation [Evidence TAS] [PMID 10570244]; GO_process: GO:0006499 - N-terminal protein myristoylation [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 10921902]
similar to AA sequence:KEGG_Orthology:K02263
Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IPI] [PMID 1331058]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IMP] [PMID 1847916]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen [Evidence IDA] [PMID 1331058]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 8893857]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000102 - L-methionine secondary active transmembrane transporter activity [Evidence IDA] [PMID 8893857]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0042883 - cysteine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0044690 - methionine import [Evidence IGI,IMP] [PMID 8893857]; GO_process: GO:0015821 - methionine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0000101 - sulfur amino acid transport [Evidence IMP] [PMID 8893857]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 12052896]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12052896]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 12052896]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16301316]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IGI,IPI,ISS] [PMID 12052896]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 16301316]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 12052896]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IMP,ISS] [PMID 11169758]
similar to AA sequence:KEGG_Orthology:K00698
Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9008706]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IMP] [PMID 9760183]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 1293886]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence TAS] [PMID 7565410]
similar to AA sequence:KEGG_Orthology:K01876
Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 2668951]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IMP,ISA] [PMID 2668951]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070146 - mitochondrial aspartyl-tRNA aminoacylation [Evidence IGI] [PMID 10710420]; GO_process: GO:0070146 - mitochondrial aspartyl-tRNA aminoacylation [Evidence IMP] [PMID 2668951]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
proteasome regulatory particle lid subunit RPN11
similar to AA sequence:KEGG_Orthology:K03030
Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19773362]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19773362]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence ISS] [PMID 12183636]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IMP] [PMID 12183636]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IMP] [PMID 12353037]; GO_process: GO:0000266 - mitochondrial fission [Evidence IMP] [PMID 19773362]; GO_process: GO:0016559 - peroxisome fission [Evidence IMP] [PMID 19773362]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12183636]; GO_process: GO:0016579 - protein deubiquitination [Evidence IMP] [PMID 12183636]; GO_process: GO:0016579 - protein deubiquitination [Evidence IGI] [PMID 14581483]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09485
Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA] [PMID 16688212]; GO_function: GO:0005516 - calmodulin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence ISS] [PMID 8406043]; GO_process: GO:0042026 - protein refolding [Evidence IGI] [PMID 16688211]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14015
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP); GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0036266 - Cdc48p-Npl4p-Vms1p AAA ATPase complex [Evidence IDA] [PMID 21070972]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 11598205]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0072671 - mitochondria-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21070972]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 14636562]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12273
GYF domain protein; involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 17804396]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 17973654]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 17973654]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 17973654]
similar to AA sequence:KEGG_Orthology:K12847
Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10022888]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 10022888]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IDA] [PMID 24681967]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11599
Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11922673]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11922673]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 10975253]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17431397]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 9491890]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9491890]
similar to AA sequence:KEGG_Orthology:K01102
Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16643908]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004741 - [pyruvate dehydrogenase (lipoamide)] phosphatase activity [Evidence IEA]; GO_function: GO:0004741 - [pyruvate dehydrogenase (lipoamide)] phosphatase activity [Evidence ISS] [PMID 16643908]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,ISS] [PMID 10580002]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IMP] [PMID 18180296]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 10580002]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IMP] [PMID 16643908]
similar to AA sequence:KEGG_Orthology:K01792
Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0047938 - glucose-6-phosphate 1-epimerase activity [Evidence IEA]; GO_function: GO:0047938 - glucose-6-phosphate 1-epimerase activity [Evidence IDA] [PMID 16857670]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IC] [PMID 16857670]
similar to AA sequence:KEGG_Orthology:K08197
Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IDA] [PMID 10748025]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 19469713]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0015344 - siderophore uptake transmembrane transporter activity [Evidence IMP,ISS] [PMID 9884238]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IDA,IMP] [PMID 9884238]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0015891 - siderophore transport [Evidence IMP] [PMID 9884238]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 9884238]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07889
Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IMP] [PMID 11872141]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 8163546]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 22748138]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 23612966]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8163546]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 22748138]; GO_process: GO:0036258 - multivesicular body assembly [Evidence IGI] [PMID 22748138]; GO_process: GO:0036010 - protein localization to endosome [Evidence IGI] [PMID 23264632]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8163546]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]
similar to AA sequence:KEGG_Orthology:K01637
Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IEA,IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IMP,ISS] [PMID 1551398]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence TAS] [PMID 11092862]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10931290]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 10931290]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA,IGI] [PMID 10526184]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 21215255]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_function: GO:0010314 - phosphatidylinositol-5-phosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_process: GO:0007231 - osmosensory signaling pathway [Evidence IGI] [PMID 10590461]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16087742]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10609
Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 19843283]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 19843283]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 9564032]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IGI] [PMID 19843283]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
putative tyrosine protein phosphatase OCA1
similar to AA sequence:KEGG_Orthology:K18043
similar to AA sequence:KEGG_Orthology:K07827
GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20162532]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 3513173]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14674766]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 6327067]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007189 - adenylate cyclase-activating G-protein coupled receptor signaling pathway [Evidence IDA] [PMID 3891097]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 8034612]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IDA] [PMID 12672825]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 16728974]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA,IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IMP,IPI,ISS] [PMID 10805724]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16314178]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19372273]; GO_process: GO:0016479 - negative regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 19270272]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17210643]; GO_process: GO:0061408 - positive regulation of transcription from RNA polymerase II promoter in response to heat stress [Evidence IMP] [PMID 20398213]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 14742425]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 14742425]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IMP] [PMID 14742425]; GO_process: GO:0070124 - mitochondrial translational initiation [Evidence IGI] [PMID 19843529]
similar to AA sequence:KEGG_Orthology:K12385
Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16138904]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008158 - hedgehog receptor activity [Evidence IEA]; GO_function: GO:0046624 - sphingolipid transporter activity [Evidence IMP] [PMID 14970192]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IMP] [PMID 14970192]; GO_process: GO:0006810 - transport [Evidence IEA]
protein-arginine omega-N methyltransferase HMT1
similar to AA sequence:KEGG_Orthology:K11434
Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8668183]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0035242 - protein-arginine omega-N asymmetric methyltransferase activity [Evidence IDA,IMP] [PMID 8647869]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA,IMP] [PMID 8647869]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI] [PMID 10952997]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI] [PMID 8668183]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0060567 - negative regulation of DNA-templated transcription, termination [Evidence IMP] [PMID 20053728]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 18515076]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 20035717]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IDA] [PMID 22997150]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IDA,IMP] [PMID 8647869]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 20053728]; GO_process: GO:0006479 - protein methylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14429
Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031166 - integral component of vacuolar membrane [Evidence IDA] [PMID 23022132]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015379 - potassium:chloride symporter activity [Evidence IMP,ISA] [PMID 23022132]; GO_process: GO:0055075 - potassium ion homeostasis [Evidence IGI] [PMID 23022132]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0034486 - vacuolar transmembrane transport [Evidence IMP] [PMID 23022132]
similar to AA sequence:KEGG_Orthology:K00565
Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia; GO_component: GO:0016591 - DNA-directed RNA polymerase II, holoenzyme [Evidence IPI] [PMID 11018011]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11018011]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004482 - mRNA (guanine-N7-)-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004482 - mRNA (guanine-N7-)-methyltransferase activity [Evidence IDA,ISS] [PMID 7623811]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA,IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IDA] [PMID 7623811]; GO_process: GO:0036265 - RNA (guanine-N7)-methylation [Evidence IEA,IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 14967145]
similar to AA sequence:KEGG_Orthology:K18171
similar to AA sequence:KEGG_Orthology:K11557
similar to AA sequence:KEGG_Orthology:K14769
Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13179
ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15049817]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 15718299]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 15718299]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 15718299]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 23788678]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15049817]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 15242642]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 15049817]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 23788678]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 15049817]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 23788678]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17675
ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; GO_component: GO:0000262 - mitochondrial chromosome [Evidence IDA] [PMID 21911497]; GO_component: GO:0045025 - mitochondrial degradosome [Evidence IDA] [PMID 12426313]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 12426313]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 17658549]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IDA] [PMID 17658549]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000372 - Group I intron splicing [Evidence IGI] [PMID 20064926]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence IMP] [PMID 21911497]; GO_process: GO:0000957 - mitochondrial RNA catabolic process [Evidence IMP] [PMID 12426313]
similar to AA sequence:KEGG_Orthology:K17260
Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IEA]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11248049]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 15657399]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 16862144]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IMP] [PMID 16862144]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IEA]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IMP] [PMID 16862144]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 18287533]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10377407]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 17118118]; GO_process: GO:0051654 - establishment of mitochondrion localization [Evidence IMP] [PMID 16107558]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP,IPI] [PMID 11248049]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10903
O-phospho-L-serine:2-oxoglutarate transaminase
similar to AA sequence:KEGG_Orthology:K00831
3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004648 - O-phospho-L-serine:2-oxoglutarate aminotransferase activity [Evidence IEA,IEA]; GO_function: GO:0004648 - O-phospho-L-serine:2-oxoglutarate aminotransferase activity [Evidence IMP,ISS] [PMID 8017107]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IMP,ISS] [PMID 8017107]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IMP] [PMID 10509016]; GO_process: GO:0009070 - serine family amino acid biosynthetic process [Evidence IMP] [PMID 1326413]
similar to AA sequence:KEGG_Orthology:K13119
similar to AA sequence:KEGG_Orthology:K19306
Methyltransferase; methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 18332120]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 9873020]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016435 - rRNA (guanine) methyltransferase activity [Evidence IMP] [PMID 18332120]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 18332120]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0070476 - rRNA (guanine-N7)-methylation [Evidence IMP] [PMID 18332120]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 18332120]
H(+)-transporting V1 sector ATPase subunit E
similar to AA sequence:KEGG_Orthology:K02150
Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11717306]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IDA] [PMID 16774922]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
similar to AA sequence:KEGG_Orthology:K14715
similar to AA sequence:KEGG_Orthology:K12396
Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IMP] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA,IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10559961]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10873
Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 12766777]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11459964]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0000150 - recombinase activity [Evidence IDA] [PMID 15205482]; GO_process: GO:0006277 - DNA amplification [Evidence IMP] [PMID 23271978]; GO_process: GO:0000730 - DNA recombinase assembly [Evidence IDA] [PMID 11459983]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 9619627]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 17096599]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 17096599]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 24190138]; GO_process: GO:0045002 - double-strand break repair via single-strand annealing [Evidence IGI] [PMID 11606529]; GO_process: GO:0000709 - meiotic joint molecule formation [Evidence IGI,IMP] [PMID 18313389]; GO_process: GO:0006301 - postreplication repair [Evidence IMP] [PMID 7038396]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IMP] [PMID 11238918]
translation initiation factor eIF2B subunit beta
similar to AA sequence:KEGG_Orthology:K03754
Beta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IGI,IPI] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IMP] [PMID 8441423]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IPI] [PMID 8336705]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI] [PMID 8164676]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI,IPI] [PMID 8887689]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 9032257]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IPI] [PMID 8336705]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IGI,IPI] [PMID 8336705]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI] [PMID 8164676]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8887689]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 9032257]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08178
Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17710650]; GO_function: GO:0015144 - carbohydrate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015355 - secondary active monocarboxylate transmembrane transporter activity [Evidence IMP] [PMID 17710650]; GO_function: GO:0097079 - selenite:proton symporter activity [Evidence IMP] [PMID 20861301]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0034219 - carbohydrate transmembrane transport [Evidence IEA]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 10198029]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0006849 - plasma membrane pyruvate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0097080 - plasma membrane selenite transport [Evidence IMP] [PMID 20861301]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12856
Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in its human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 17934474]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720285]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 17934474]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17934474]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0030619 - U1 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030620 - U2 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IEA]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 9848662]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IEA]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0097157 - pre-mRNA intronic binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 17626844]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IMP] [PMID 10628969]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IMP] [PMID 17934474]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IDA] [PMID 23393194]
similar to AA sequence:KEGG_Orthology:K11888
Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10913188]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8065366]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21075847]; GO_process: GO:0031144 - proteasome localization [Evidence IEA]; GO_process: GO:0031144 - proteasome localization [Evidence IMP] [PMID 21075847]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01868
Threonyl-tRNA synthetase; essential cytoplasmic protein; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 2995918]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence ISA] [PMID 2995918]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IDA] [PMID 8143729]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 10471698]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence ISA] [PMID 2995918]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence IDA] [PMID 8143729]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04508
WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9651685]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP,IPI] [PMID 9651685]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IPI] [PMID 11711434]; GO_process: GO:0032874 - positive regulation of stress-activated MAPK cascade [Evidence IMP] [PMID 18487345]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 19379692]
Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10438536]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10438536]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 10438536]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10438536]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0030133 - transport vesicle [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 10438536]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 15788396]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15788396]; GO_process: GO:0051601 - exocyst localization [Evidence IMP] [PMID 15788396]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI,IMP] [PMID 10438536]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 15788396]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IMP,IPI] [PMID 11425851]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 10438536]
similar to AA sequence:KEGG_Orthology:K15223
Non-essential sumoylated hypothetical protein; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
phosphopantothenate--cysteine ligase CAB2
similar to AA sequence:KEGG_Orthology:K01922
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004632 - phosphopantothenate--cysteine ligase activity [Evidence IEA]; GO_function: GO:0004632 - phosphopantothenate--cysteine ligase activity [Evidence ISS] [PMID 11923312]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 11923312]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]
similar to AA sequence:KEGG_Orthology:K13201
Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8413212]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8413213]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8413212]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15964806]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 8413212]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 8413213]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008266 - poly(U) RNA binding [Evidence IDA] [PMID 8413213]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA] [PMID 10892745]; GO_process: GO:0043488 - regulation of mRNA stability [Evidence IMP] [PMID 15964806]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]
similar to AA sequence:KEGG_Orthology:K11870
Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1429680]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15635103]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15635103]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 1429680]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 1429680]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 2050695]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00864
Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004370 - glycerol kinase activity [Evidence IEA,IEA]; GO_function: GO:0004370 - glycerol kinase activity [Evidence IMP,ISS] [PMID 8358828]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0019563 - glycerol catabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence TAS] [PMID 8358828]; GO_process: GO:0006072 - glycerol-3-phosphate metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01094
Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 20485265]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008962 - phosphatidylglycerophosphatase activity [Evidence IEA]; GO_function: GO:0008962 - phosphatidylglycerophosphatase activity [Evidence IDA,IGI,IMP] [PMID 20485265]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IMP] [PMID 20485265]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006655 - phosphatidylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0046838 - phosphorylated carbohydrate dephosphorylation [Evidence IMP] [PMID 20485265]
glucose-induced degradation complex subunit GID7
Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]
similar to AA sequence:KEGG_Orthology:K00107
D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10094636]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003885 - D-arabinono-1,4-lactone oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003885 - D-arabinono-1,4-lactone oxidase activity [Evidence IDA] [PMID 10094636]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_function: GO:0016899 - oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10094636]; GO_process: GO:0070485 - dehydro-D-arabinono-1,4-lactone biosynthetic process [Evidence IMP] [PMID 10094636]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K13093
Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs); GO_component: GO:0005686 - U2 snRNP [Evidence TAS] [PMID 11804584]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP,ISS] [PMID 9710584]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI,IPI] [PMID 9710584]
Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
mitogen-activated protein kinase kinase kinase STE11
similar to AA sequence:KEGG_Orthology:K11228
similar to AA sequence:KEGG_Orthology:K15083
Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IDA] [PMID 16675952]; GO_component: GO:0000113 - nucleotide-excision repair factor 4 complex [Evidence IDA] [PMID 9497356]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 9497356]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9497356]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000715 - nucleotide-excision repair, DNA damage recognition [Evidence IDA,IMP] [PMID 15177043]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16675952]
similar to AA sequence:KEGG_Orthology:K05351
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IEA]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IDA,ISS] [PMID 8125328]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEP] [PMID 8125328]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03293
trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase
similar to AA sequence:KEGG_Orthology:K01240
Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016799 - hydrolase activity, hydrolyzing N-glycosyl compounds [Evidence IEA]; GO_function: GO:0070635 - nicotinamide riboside hydrolase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0070636 - nicotinic acid riboside hydrolase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0050263 - ribosylpyrimidine nucleosidase activity [Evidence IDA] [PMID 11872485]; GO_function: GO:0050263 - ribosylpyrimidine nucleosidase activity [Evidence IDA] [PMID 12111094]; GO_function: GO:0045437 - uridine nucleosidase activity [Evidence IEA]; GO_function: GO:0045437 - uridine nucleosidase activity [Evidence IDA] [PMID 19001417]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 19001417]; GO_process: GO:0006216 - cytidine catabolic process [Evidence IMP] [PMID 23670538]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019358 - nicotinate nucleotide salvage [Evidence IGI] [PMID 17482543]; GO_process: GO:0046135 - pyrimidine nucleoside catabolic process [Evidence IDA] [PMID 11872485]; GO_process: GO:0046135 - pyrimidine nucleoside catabolic process [Evidence IDA] [PMID 12111094]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IMP] [PMID 11872485]; GO_process: GO:0006218 - uridine catabolic process [Evidence IMP] [PMID 23670538]
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA] [PMID 20308326]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA] [PMID 8378310]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IMP] [PMID 15254252]; GO_function: GO:0001088 - TFIIE-class binding transcription factor activity [Evidence IDA] [PMID 8790357]; GO_function: GO:0001095 - TFIIE-class transcription factor binding [Evidence IDA] [PMID 8790357]; GO_function: GO:0001097 - TFIIH-class transcription factor binding [Evidence IDA] [PMID 10973956]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 12482986]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11470794]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8187178]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9891034]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11427713]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11781332]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20035756]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005227 - calcium activated cation channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IDA] [PMID 11781332]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005267 - potassium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005272 - sodium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IDA] [PMID 1700419]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11427713]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11781332]; GO_process: GO:0006811 - ion transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18337
Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06158
Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; GO_component: GO:0005829 - cytosol [Evidence IPI] [PMID 9234705]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 9234705]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7621831]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006448 - regulation of translational elongation [Evidence IMP,IPI] [PMID 9234705]
similar to AA sequence:KEGG_Orthology:K12585
Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; has similarity to E. coli RNase R and to human DIS3; mutations in Dis3p corresponding to human mutations implicated in multiple myeloma cause phenotypes suggesting impaired exosome function; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9562621]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IDA,IMP] [PMID 17173052]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IDA,IMP] [PMID 17643380]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA,IMP] [PMID 19060886]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 19060898]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA,IMP] [PMID 19129231]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA,IMP] [PMID 17643380]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IMP] [PMID 11352936]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 19481524]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IMP] [PMID 11030620]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 15935759]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18940861]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IGI] [PMID 15145828]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA,IMP] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
SKI complex subunit WD repeat protein SKI8
similar to AA sequence:KEGG_Orthology:K12601
Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype; GO_component: GO:0055087 - Ski complex [Evidence IDA] [PMID 10744028]; GO_component: GO:0055087 - Ski complex [Evidence IDA,IPI] [PMID 18042677]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 14992724]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 14992724]; GO_process: GO:0065004 - protein-DNA complex assembly [Evidence IMP] [PMID 14992724]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP,IPI] [PMID 14992724]
similar to AA sequence:KEGG_Orthology:K12855
Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]
similar to AA sequence:KEGG_Orthology:K11654
ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide; GO_component: GO:0008623 - CHRAC [Evidence IPI,ISS] [PMID 14673157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11238381]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 19203228]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16227570]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19203228]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 11238381]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA,IMP] [PMID 16227570]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 17689493]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 14673157]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17689493]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IGI] [PMID 18075583]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP] [PMID 12624196]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 15116071]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 17949749]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16227570]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI] [PMID 12504018]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 2203793]; GO_function: GO:1901235 - (R)-carnitine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 2203793]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_function: GO:0034228 - ethanolamine transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_process: GO:1900749 - (R)-carnitine transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015871 - choline transport [Evidence IMP] [PMID 2203793]; GO_process: GO:0015871 - choline transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0034229 - ethanolamine transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0031460 - glycine betaine transport [Evidence IMP] [PMID 16487344]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10356
One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16824951]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 20647997]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016459 - myosin complex [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000146 - microfilament motor activity [Evidence IDA] [PMID 16824951]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 18177206]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 16824951]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 8614799]; GO_process: GO:0006970 - response to osmotic stress [Evidence TAS] [PMID 10652251]; GO_process: GO:0009651 - response to salt stress [Evidence IGI,IPI] [PMID 12391157]
similar to AA sequence:KEGG_Orthology:K12572
Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; GO_component: GO:0031251 - PAN complex [Evidence IDA] [PMID 8816488]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004535 - poly(A)-specific ribonuclease activity [Evidence IDA,IMP] [PMID 8816488]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11953437]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP,IPI] [PMID 8816488]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IPI] [PMID 11953437]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11517
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 3004948]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 3004948]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03135
TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9083082]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 22553352]; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 11514624]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IMP] [PMID 11792713]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IMP] [PMID 22452743]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA,IGI,IMP] [PMID 10625610]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 22553352]
similar to AA sequence:KEGG_Orthology:K09500
Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
similar to AA sequence:KEGG_Orthology:K16945
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005619 - ascospore wall [Evidence IDA] [PMID 8636217]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 1934633]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 18826657]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 8791410]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0072687 - meiotic spindle [Evidence IDA] [PMID 18826657]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 18826657]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 18826657]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IC] [PMID 10882120]; GO_process: GO:0000281 - mitotic cytokinesis [Evidence IMP] [PMID 4950437]; GO_process: GO:0045860 - positive regulation of protein kinase activity [Evidence IDA] [PMID 14527412]
similar to AA sequence:KEGG_Orthology:K00164
Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IEA,IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016624 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity [Evidence IEA,IEA]; GO_function: GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity [Evidence TAS] [PMID 9175438]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
Double-strand-break repair protein rad21-like protein 1
similar to AA sequence:KEGG_Orthology:K06670
Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12857851]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 12857851]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 12857851]; GO_process: GO:0007015 - actin filament organization [Evidence IDA] [PMID 12857851]; GO_process: GO:0001300 - chronological cell aging [Evidence IGI,IMP] [PMID 15024029]
similar to AA sequence:KEGG_Orthology:K02332
Mitochondrial DNA polymerase gamma subunit; conserved C-terminal segment is required for the maintenance of mitochondrial genome; its human ortholog, POLG, can rescue mip1 phenotypes, and mutations in POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit; GO_component: GO:0005760 - gamma DNA polymerase complex [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10567545]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence IDA] [PMID 20601675]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 20601675]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence IDA] [PMID 12023279]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence IMP] [PMID 2684980]
hypothetical protein required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15060142]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11114193]
similar to AA sequence:KEGG_Orthology:K16261
Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IMP] [PMID 3552672]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015175 - neutral amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IDA,IGI] [PMID 8455553]; GO_process: GO:0015804 - neutral amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0015824 - proline transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11559
DNA-directed RNA polymerase I subunit RPA43
similar to AA sequence:KEGG_Orthology:K03004
RNA polymerase I subunit A43; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 7592632]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02830
Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins; GO_component: GO:0030896 - checkpoint clamp complex [Evidence IEA]; GO_component: GO:0030896 - checkpoint clamp complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0030896 - checkpoint clamp complex [Evidence IDA] [PMID 9891048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11356855]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 12604797]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 9564050]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 17624540]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10511543]
Protein required for cvt-vesicle/autophagosome fusion with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate; GO_component: GO:0035658 - Mon1-Ccz1 complex [Evidence IPI] [PMID 20797862]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12387888]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12364329]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0032585 - multivesicular body membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 12387888]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048278 - vesicle docking [Evidence IMP] [PMID 14662743]
RuvB family ATP-dependent DNA helicase reptin
similar to AA sequence:KEGG_Orthology:K11338
ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0097255 - R2TP complex [Evidence IDA] [PMID 15766533]; GO_component: GO:0097255 - R2TP complex [Evidence IPI] [PMID 18268103]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IDA] [PMID 22100294]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11604509]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 20553504]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 18234224]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 11604509]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 14645854]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11604509]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11278922]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
mitochondrial 37S ribosomal protein MRPS17
similar to AA sequence:KEGG_Orthology:K02961
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24390141]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12181333]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 16251346]; GO_function: GO:0008157 - protein phosphatase 1 binding [Evidence IDA] [PMID 12356757]; GO_function: GO:0008157 - protein phosphatase 1 binding [Evidence IPI] [PMID 8754819]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 12356757]; GO_process: GO:0030866 - cortical actin cytoskeleton organization [Evidence IMP] [PMID 12181333]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 16251346]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 8688556]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00626
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 5571830]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IDA] [PMID 7989303]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at the plasma membrane; recruited to the plasma membrane via a conserved basic patch near its N-terminus; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19075114]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0090002 - establishment of protein localization to plasma membrane [Evidence IMP] [PMID 19075114]
Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K14771
Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030692 - Noc4p-Nop14p complex [Evidence IPI] [PMID 12446671]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12446671]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12446671]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 12446671]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15108
Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 12411483]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0015234 - thiamine transmembrane transporter activity [Evidence IDA] [PMID 12411483]; GO_process: GO:0030974 - thiamine pyrophosphate transport [Evidence IDA,IMP] [PMID 12411483]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Glycosylated integral ER membrane hypothetical protein; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 23275891]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
similar to AA sequence:KEGG_Orthology:K14950
P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 11791712]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12058017]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22745129]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence IDA] [PMID 12058017]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence IDA] [PMID 22745129]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 12058017]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 24392018]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055092 - sterol homeostasis [Evidence IMP] [PMID 22918956]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 12058017]
similar to AA sequence:KEGG_Orthology:K18064
similar to AA sequence:KEGG_Orthology:K14526
Subunit of both RNase MRP and nuclear RNase P; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9618478]; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IPI] [PMID 17881380]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IMP] [PMID 9618478]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IDA] [PMID 9620854]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000171 - ribonuclease MRP activity [Evidence IDA,IMP] [PMID 9620854]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IEA]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IDA,IMP] [PMID 9620854]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0034965 - intronic box C/D snoRNA processing [Evidence IDA] [PMID 18713869]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 14729943]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9618478]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9620854]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9618478]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9620854]
XP_962611|transcriptional activator xlnR [Neurospora crassa OR74A]
similar to AA sequence:KEGG_Orthology:K06067
similar to AA sequence:KEGG_Orthology:K03949
similar to AA sequence:KEGG_Orthology:K07901
Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; GO_component: GO:0030478 - actin cap [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9128251]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0030133 - transport vesicle [Evidence TAS] [PMID 12665530]; GO_component: GO:0030133 - transport vesicle [Evidence IDA] [PMID 23079598]; GO_component: GO:0030658 - transport vesicle membrane [Evidence IEA]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 12456647]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 2111819]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 2111819]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 9017592]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IMP] [PMID 9425151]; GO_process: GO:0006914 - autophagy [Evidence IGI,IMP] [PMID 20444978]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IDA] [PMID 15772160]; GO_process: GO:0007107 - membrane addition at site of cytokinesis [Evidence IEP,IGI,IMP] [PMID 12456647]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence TAS] [PMID 10652251]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IMP] [PMID 9017592]
similar to AA sequence:KEGG_Orthology:K01890
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0009328 - phenylalanine-tRNA ligase complex [Evidence IDA] [PMID 3049607]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 16162501]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 166841]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 16162501]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 166841]; GO_process: GO:0006412 - translation [Evidence IEA]
Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10207098]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10207098]; GO_function: GO:0051087 - chaperone binding [Evidence IMP,IPI] [PMID 9632755]; GO_process: GO:0043392 - negative regulation of DNA binding [Evidence IDA] [PMID 23022381]; GO_process: GO:0032212 - positive regulation of telomere maintenance via telomerase [Evidence IDA,IMP] [PMID 17389357]; GO_process: GO:0006457 - protein folding [Evidence IMP,IPI] [PMID 9632755]; GO_process: GO:0051972 - regulation of telomerase activity [Evidence IDA,IMP] [PMID 17389357]
hypothetical protein that associates with translating ribosomes; interacts with GTPase Rbg1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0042788 - polysomal ribosome [Evidence IDA] [PMID 21076151]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]
similar to AA sequence:KEGG_Orthology:K14963
Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IMP] [PMID 11752412]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11687631]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11752412]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 11742990]
similar to AA sequence:KEGG_Orthology:K00228
Coproporphyrinogen III oxidase; an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 3516695]; GO_function: GO:0004109 - coproporphyrinogen oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004109 - coproporphyrinogen oxidase activity [Evidence IMP] [PMID 2838478]; GO_function: GO:0004109 - coproporphyrinogen oxidase activity [Evidence IDA] [PMID 3516695]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K19307
Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 24335083]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA,ISS] [PMID 21858014]; GO_function: GO:0070042 - rRNA (uridine-N3-)-methyltransferase activity [Evidence IMP] [PMID 24335083]; GO_process: GO:0032259 - methylation [Evidence IC] [PMID 21858014]; GO_process: GO:0070475 - rRNA base methylation [Evidence IMP] [PMID 24335083]
glucose-induced degradation complex subunit FYV10
similar to AA sequence:KEGG_Orthology:K18624
Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 22044534]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IMP] [PMID 18355271]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]
similar to AA sequence:KEGG_Orthology:K02259
Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9228094]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016653 - oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Evidence IMP] [PMID 11248251]; GO_function: GO:0016653 - oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Evidence IGI] [PMID 11788607]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IEA]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IGI,IMP] [PMID 11788607]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
ER membrane hypothetical protein; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 23275891]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 24706893]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 24706893]; GO_function: GO:0019172 - glyoxalase III activity [Evidence IDA] [PMID 24302734]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031669 - cellular response to nutrient levels [Evidence IMP] [PMID 24706893]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17395014]; GO_process: GO:0019243 - methylglyoxal catabolic process to D-lactate [Evidence IDA] [PMID 24302734]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16075
Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10400670]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IDA] [PMID 12628916]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015693 - magnesium ion transport [Evidence IEA]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IDA] [PMID 12628916]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08850
Aurora kinase of conserved chromosomal passenger complex; mediates release on mono-oriented kinetochores from microtubules in meiosis I, also release of kinetochores from cluster at SPBs at meiosis exit; helps maintain condensed chromosomes during anaphase, early telophase; required for SPB cohesion and prevention of multipolar spindle formation; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0032133 - chromosome passenger complex [Evidence IDA] [PMID 19158380]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 12566427]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 12566427]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11511347]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 12566427]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 10072382]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16143104]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 23142046]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IMP] [PMID 10072382]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8293973]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IMP] [PMID 17289568]; GO_process: GO:0045144 - meiotic sister chromatid segregation [Evidence IMP] [PMID 17289568]; GO_process: GO:0045144 - meiotic sister chromatid segregation [Evidence IMP] [PMID 17371833]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 12566427]; GO_process: GO:1901925 - negative regulation of protein import into nucleus during spindle assembly checkpoint [Evidence IMP] [PMID 23177738]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0090232 - positive regulation of spindle checkpoint [Evidence IMP] [PMID 16327780]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA,IMP] [PMID 17504936]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 23142046]; GO_process: GO:0032465 - regulation of cytokinesis [Evidence IMP] [PMID 16615892]
Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable; ISU1 has a paralog, ISU2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10468587]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15143178]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 12970193]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP,ISS] [PMID 10468587]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP,ISS] [PMID 10588895]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI] [PMID 12970193]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15143178]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IGI] [PMID 17283054]
similar to AA sequence:KEGG_Orthology:K15564
Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15520468]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15520468]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0070692 - trimeric positive transcription elongation factor complex b [Evidence IDA] [PMID 7565723]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IC] [PMID 11118453]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0032786 - positive regulation of DNA-templated transcription, elongation [Evidence IDA] [PMID 9110987]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15520468]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IPI] [PMID 17545469]; GO_process: GO:0006468 - protein phosphorylation [Evidence IPI] [PMID 7565723]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11836
Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008242 - omega peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 19410548]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05605
3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IDA,ISS] [PMID 12697341]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12697341]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006574 - valine catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18532
Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 16287850]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10692169]; GO_component: GO:0030684 - preribosome [Evidence IPI] [PMID 16287850]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IMP,ISS] [PMID 16287850]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10692169]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP,IPI] [PMID 16287850]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 16287850]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01556
Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0030429 - kynureninase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0030429 - kynureninase activity [Evidence IMP] [PMID 12062417]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA,IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0097053 - L-kynurenine catabolic process [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0043420 - anthranilate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0019805 - quinolinate biosynthetic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00264
NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051538 - 3 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016040 - glutamate synthase (NADH) activity [Evidence IEA,IEA]; GO_function: GO:0016040 - glutamate synthase (NADH) activity [Evidence IDA,IMP] [PMID 7836314]; GO_function: GO:0015930 - glutamate synthase activity [Evidence IEA]; GO_function: GO:0045181 - glutamate synthase activity, NAD(P)H as acceptor [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016638 - oxidoreductase activity, acting on the CH-NH2 group of donors [Evidence IEA]; GO_function: GO:0016639 - oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0097054 - L-glutamate biosynthetic process [Evidence IEA]; GO_process: GO:0019676 - ammonia assimilation cycle [Evidence IEP] [PMID 11356843]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IEP] [PMID 9657994]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
translation initiation factor eIF3 subunit i
similar to AA sequence:KEGG_Orthology:K03246
eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0002188 - translation reinitiation [Evidence IMP] [PMID 20679478]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
similar to AA sequence:KEGG_Orthology:K01061
Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008806 - carboxymethylenebutenolidase activity [Evidence IEA]; GO_function: GO:0008806 - carboxymethylenebutenolidase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12597
Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935759]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11489916]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IGI] [PMID 15935759]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15828860]; GO_process: GO:0071031 - nuclear mRNA surveillance of mRNA 3'-end processing [Evidence IGI] [PMID 17410208]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IGI] [PMID 18591258]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI] [PMID 15935758]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI] [PMID 18007593]; GO_process: GO:0071037 - nuclear polyadenylation-dependent snRNA catabolic process [Evidence IGI] [PMID 15935758]; GO_process: GO:0071036 - nuclear polyadenylation-dependent snoRNA catabolic process [Evidence IGI] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]
Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
hypothetical protein; null mutant displays sensitivity to DNA damaging agents; may have a role in lipid metabolism, based on localization to lipid droplets; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12077312]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02995
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 18782943]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IBA]
Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1; GO_component: GO:0044695 - Dsc E3 ubiquitin ligase complex [Evidence IDA] [PMID 22681890]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11788821]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP,ISS] [PMID 11788821]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 11788821]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 11788821]
mitochondrial iron ion transporter (predicted)
similar to AA sequence:KEGG_Orthology:K01870
Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 7607232]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence ISA] [PMID 7607232]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence ISA] [PMID 7607232]; GO_process: GO:0070152 - mitochondrial isoleucyl-tRNA aminoacylation [Evidence IC] [PMID 7607232]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7607232]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
mitochondrial 54S ribosomal protein YmL11
similar to AA sequence:KEGG_Orthology:K02864
Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18802
Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17179087]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence ISS] [PMID 17179087]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IDA,IMP] [PMID 22277648]; GO_function: GO:0008242 - omega peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0008233 - peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 17179087]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IDA,IMP] [PMID 22277648]
similar to AA sequence:KEGG_Orthology:K12872
Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 9528778]
similar to AA sequence:KEGG_Orthology:K04706
SUMO E3 ligase; catalyzes sumoylation of Yku70p/Yku80p and Sir4p promoting chromatin anchoring; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length; NFI1 has a paralog, SIZ1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16204216]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 12761287]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IMP] [PMID 23122649]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA,IMP] [PMID 23122649]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence TAS] [PMID 12402242]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 16204216]; GO_process: GO:0060969 - negative regulation of gene silencing [Evidence IMP] [PMID 22345352]; GO_process: GO:0016925 - protein sumoylation [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA] [PMID 12761287]; GO_process: GO:0016925 - protein sumoylation [Evidence IMP] [PMID 22345352]; GO_process: GO:0016925 - protein sumoylation [Evidence IMP] [PMID 23122649]
proteasome core particle subunit alpha 2
similar to AA sequence:KEGG_Orthology:K02726
Alpha 2 subunit of the 20S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01673
Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004089 - carbonate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0004089 - carbonate dehydratase activity [Evidence IDA] [PMID 15096093]; GO_function: GO:0004089 - carbonate dehydratase activity [Evidence IDA] [PMID 15813743]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0015976 - carbon utilization [Evidence IEA]; GO_process: GO:0071244 - cellular response to carbon dioxide [Evidence IMP] [PMID 22253597]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15096093]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K09584
Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 1761554]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP] [PMID 11157982]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16413482]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16002399]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 11157982]
hypothetical protein; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to Erwinia pyrifoliae Ep1/96 (NCBI:YP_002650176.1)
Meiotic expression up-regulated protein-like protein
similar to AA sequence:KEGG_Orthology:K01238
Cell wall protein related to glucanases; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11958935]; GO_component: GO:0005759 - mitochondrial matrix [Evidence TAS] [PMID 11958935]; GO_function: GO:0015926 - glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence TAS] [PMID 11958935]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01078
similar to AA sequence:KEGG_Orthology:K03626
Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005854 - nascent polypeptide-associated complex [Evidence IDA] [PMID 10219998]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0070300 - phosphatidic acid binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 9482879]; GO_process: GO:0051083 - 'de novo' cotranslational protein folding [Evidence IPI] [PMID 10219998]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IGI] [PMID 10518932]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13126
Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15630021]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15769879]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15630021]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15769879]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 8631901]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA,IMP] [PMID 9193001]; GO_function: GO:0008428 - ribonuclease inhibitor activity [Evidence IDA] [PMID 11889048]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA,IMP] [PMID 17766253]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA,IMP] [PMID 10357826]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11367
Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 15647753]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 15647753]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12504018]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12682017]; GO_component: GO:0030874 - nucleolar chromatin [Evidence IDA] [PMID 17259992]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 21623345]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 10811623]; GO_function: GO:0031490 - chromatin DNA binding [Evidence IDA] [PMID 12682017]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 15647753]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0070615 - nucleosome-dependent ATPase activity [Evidence IDA] [PMID 10811623]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000182 - rDNA binding [Evidence IDA] [PMID 17259992]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 10811623]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0071894 - histone H2B conserved C-terminal lysine ubiquitination [Evidence IMP] [PMID 22549955]; GO_process: GO:2000104 - negative regulation of DNA-dependent DNA replication [Evidence IGI] [PMID 18245327]; GO_process: GO:0071441 - negative regulation of histone H3-K14 acetylation [Evidence IMP] [PMID 19948887]; GO_process: GO:2000616 - negative regulation of histone H3-K9 acetylation [Evidence IMP] [PMID 19948887]; GO_process: GO:1900050 - negative regulation of histone exchange [Evidence IMP] [PMID 22922743]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 16606615]; GO_process: GO:0016584 - nucleosome positioning [Evidence IGI] [PMID 16468993]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 17949749]; GO_process: GO:1902275 - regulation of chromatin organization [Evidence IMP] [PMID 22922743]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IGI] [PMID 10811623]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16468993]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001178 - regulation of transcriptional start site selection at RNA polymerase II promoter [Evidence IGI] [PMID 19948887]; GO_process: GO:0006363 - termination of RNA polymerase I transcription [Evidence IGI] [PMID 17259992]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI,IMP] [PMID 12504018]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IPI] [PMID 12682017]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
chromodomain-helicase-DNA-binding protein 1
similar to AA sequence:KEGG_Orthology:K08596
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10713161]; GO_function: GO:0016929 - SUMO-specific protease activity [Evidence IDA,IMP] [PMID 10713161]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA,IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence ISS] [PMID 10094048]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IDA] [PMID 10713161]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IMP] [PMID 11333221]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP] [PMID 10713162]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 10713161]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 11333221]; GO_process: GO:0016926 - protein desumoylation [Evidence IDA,IMP] [PMID 10713161]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17804
Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); TIM23 complex is short for the translocase of the inner mitochondrial membrane; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14517234]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14638855]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence IMP] [PMID 11344168]; GO_function: GO:0051087 - chaperone binding [Evidence IPI] [PMID 7809127]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 10824101]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 11344168]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 1396562]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 18400944]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative dihydrokaempferol 4-reductase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence ISA] [PMID 19577617]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
Rpd3L histone deacetylase complex subunit DEP1
similar to AA sequence:KEGG_Orthology:K01855
tRNA:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9430663]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9430663]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 9430663]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 9430663]
similar to AA sequence:KEGG_Orthology:K14809
Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients; GO_component: GO:0030686 - 90S preribosome [Evidence IDA,IPI] [PMID 21825077]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9769101]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 9769101]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 2408148]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 2408148]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 21825077]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 2408148]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04532
Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019781 - NEDD8 activating enzyme activity [Evidence IMP,ISS] [PMID 9531531]; GO_function: GO:0019781 - NEDD8 activating enzyme activity [Evidence IDA,ISS] [PMID 9545234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence ISS] [PMID 9531531]; GO_process: GO:0045116 - protein neddylation [Evidence IDA,IMP,ISS] [PMID 9545234]
Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 16567426]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA,IMP] [PMID 18508919]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP,IPI] [PMID 18508919]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 17606994]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IGI] [PMID 16874095]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 17606994]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 9545237]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IGI,IPI] [PMID 22492205]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI] [PMID 22492205]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 16874095]
similar to AA sequence:KEGG_Orthology:K03128
TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12389
Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis); GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 10319861]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 9753630]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IBA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031301 - integral component of organelle membrane [Evidence IBA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IMP] [PMID 14660799]; GO_process: GO:0015819 - lysine transport [Evidence IMP] [PMID 14660799]; GO_process: GO:0051453 - regulation of intracellular pH [Evidence IMP] [PMID 10191121]; GO_process: GO:0051453 - regulation of intracellular pH [Evidence IMP] [PMID 10319861]; GO_process: GO:0051453 - regulation of intracellular pH [Evidence IMP] [PMID 16423829]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IBA]; GO_process: GO:0007033 - vacuole organization [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K06961
Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11027267]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11027267]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11996121]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 12150911]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16135509]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042171 - lysophosphatidic acid acyltransferase activity [Evidence IDA] [PMID 20016004]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 16135509]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006642 - triglyceride mobilization [Evidence IDA,IMP] [PMID 16135509]
Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 9023541]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 9459307]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IEP] [PMID 9459307]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 9023541]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IMP] [PMID 9813355]
similar to AA sequence:KEGG_Orthology:K09880
Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0043715 - 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity [Evidence IEA]; GO_function: GO:0043716 - 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity [Evidence IEA]; GO_function: GO:0043874 - acireductone synthase activity [Evidence IEA,IEA]; GO_function: GO:0043874 - acireductone synthase activity [Evidence ISS] [PMID 15102328]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0019284 - L-methionine biosynthetic process from S-adenosylmethionine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15082
stress-responsive transcription factor HSF1
similar to AA sequence:KEGG_Orthology:K09419
proteasome core particle subunit alpha 4
similar to AA sequence:KEGG_Orthology:K02731
Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16806052]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 9799224]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18504300]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03130
similar to AA sequence:KEGG_Orthology:K14686
High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10924521]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005375 - copper ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015088 - copper uptake transmembrane transporter activity [Evidence IDA] [PMID 10924521]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 10924521]; GO_process: GO:0035434 - copper ion transmembrane transport [Evidence IEA]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
mRNA-binding translational repressor SSD1
similar to AA sequence:KEGG_Orthology:K18748
protein phosphatase 2A regulatory subunit CDC55
similar to AA sequence:KEGG_Orthology:K04354
Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12388751]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12388751]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21536748]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12388751]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence ISA] [PMID 1656238]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000078 - cytokinesis after mitosis checkpoint [Evidence IGI] [PMID 20980617]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IMP] [PMID 16314395]; GO_process: GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 21536748]; GO_process: GO:0061586 - positive regulation of transcription by transcription factor localization [Evidence IMP] [PMID 23275436]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 22581371]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 22814605]; GO_process: GO:0034504 - protein localization to nucleus [Evidence IMP] [PMID 23275436]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02266
Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IPI] [PMID 1331058]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 1331058]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 7851399]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 10429195]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8395517]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0097250 - mitochondrial respiratory chain supercomplex assembly [Evidence IMP] [PMID 22342701]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006119 - oxidative phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02132
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IDA] [PMID 17082766]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IMP,ISS] [PMID 2876995]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA,IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18722382]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP] [PMID 1827117]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP,ISS] [PMID 2876995]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 2876995]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03026
RNA polymerase III subunit C53; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IEA]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 1406624]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IEA]
1-acylglycerol-3-phosphate O-acyltransferase SLC1
similar to AA sequence:KEGG_Orthology:K13509
1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IDA] [PMID 9212466]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IGI] [PMID 17675291]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K10524
Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0034317 - nicotinic acid riboside kinase activity [Evidence ISS] [PMID 17914902]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0050262 - ribosylnicotinamide kinase activity [Evidence IEA,IEA]; GO_function: GO:0050262 - ribosylnicotinamide kinase activity [Evidence IDA] [PMID 15137942]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 15137942]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IGI] [PMID 17914902]; GO_process: GO:0019359 - nicotinamide nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0046495 - nicotinamide riboside metabolic process [Evidence IDA,IGI] [PMID 15137942]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12619
similar to AA sequence:KEGG_Orthology:K12236
Protein that binds to Fpr1p; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10998178]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 10998178]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10736
Essential chromatin-associated protein; involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins; required to stabilize the catalytic subunit of DNA polymerase-alpha; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11168584]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 13680157]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9154825]; GO_component: GO:0005657 - replication fork [Evidence IMP] [PMID 15494305]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 10783164]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 15494305]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 19605346]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16675460]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19605346]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP,IPI] [PMID 9154825]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IGI,IMP] [PMID 11168584]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 9154825]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP,IPI] [PMID 16085704]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP,IPI] [PMID 16328881]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP,IPI] [PMID 16085704]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress; GO_component: GO:0071944 - cell periphery [Evidence IDA] [PMID 12869188]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 16262726]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12869188]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19477927]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19477927]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 10848624]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IGI] [PMID 10848624]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IGI] [PMID 16262726]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:2000114 - regulation of establishment of cell polarity [Evidence IGI] [PMID 19477927]; GO_process: GO:0017157 - regulation of exocytosis [Evidence IGI] [PMID 19477927]; GO_process: GO:0006810 - transport [Evidence IEA]
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IEA]; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IDA,IPI] [PMID 2832951]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7828851]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 2832951]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 2832951]; GO_process: GO:0043457 - regulation of cellular respiration [Evidence IMP] [PMID 2182199]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Similar to Conserved oligomeric Golgi complex subunit 1; acc. no. Q9VGC3
bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
similar to AA sequence:KEGG_Orthology:K18369
Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IMP] [PMID 12499363]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0033833 - hydroxymethylfurfural reductase (NADH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006069 - ethanol oxidation [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IDA] [PMID 8483449]; GO_process: GO:0033859 - furaldehyde metabolic process [Evidence IMP] [PMID 16652391]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 22678362]
similar to AA sequence:KEGG_Orthology:K02541
Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IPI] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 12480933]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9554851]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 12060653]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 19064704]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 19064704]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
similar to AA sequence:KEGG_Orthology:K05916
Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15611069]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15611069]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008941 - nitric oxide dioxygenase activity [Evidence IEA]; GO_function: GO:0016966 - nitric oxide reductase activity [Evidence IMP] [PMID 10758168]; GO_function: GO:0016966 - nitric oxide reductase activity [Evidence IMP] [PMID 15611069]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0019825 - oxygen binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA] [PMID 8810268]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA] [PMID 9545281]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015671 - oxygen transport [Evidence IEA]; GO_process: GO:0009636 - response to toxic substance [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03860
Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs; GO_component: GO:0000506 - glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [Evidence IGI,ISA] [PMID 9729469]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 8910381]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity [Evidence IC] [PMID 9729469]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IDA,IMP] [PMID 8910381]
similar to AA sequence:KEGG_Orthology:K15356
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9395539]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005458 - GDP-mannose transmembrane transporter activity [Evidence IDA] [PMID 20576760]; GO_function: GO:0005458 - GDP-mannose transmembrane transporter activity [Evidence IMP] [PMID 9395539]; GO_function: GO:0005338 - nucleotide-sugar transmembrane transporter activity [Evidence IEA]; GO_process: GO:0015784 - GDP-mannose transport [Evidence IMP] [PMID 9395539]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:1901679 - nucleotide transmembrane transport [Evidence IEA]; GO_process: GO:0015780 - nucleotide-sugar transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08736
Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability; GO_component: GO:0032302 - MutSbeta complex [Evidence IPI] [PMID 8805366]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000228 - nuclear chromosome [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 8805366]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0000403 - Y-form DNA binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0000406 - double-strand/single-strand DNA junction binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IDA] [PMID 17636021]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 15920474]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IBA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 8510668]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9520271]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 8849883]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IBA]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IGI,IMP] [PMID 9256462]
similar to AA sequence:KEGG_Orthology:K05824
Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0047046 - homoisocitrate dehydrogenase activity [Evidence IEA]; GO_function: GO:0047046 - homoisocitrate dehydrogenase activity [Evidence IDA] [PMID 17223711]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IC] [PMID 17223711]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
SUMO-targeted ubiquitin ligase complex subunit SLX8
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; GO_component: GO:0033768 - SUMO-targeted ubiquitin ligase complex [Evidence IDA] [PMID 17848550]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19270524]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 17728242]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 17848550]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 18032921]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 11139495]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 16325482]; GO_process: GO:0016925 - protein sumoylation [Evidence IGI,IMP] [PMID 16387868]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 17728242]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 17848550]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 18032921]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 16428246]
similar to AA sequence:KEGG_Orthology:K15264
rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23913415]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10649453]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0009383 - rRNA (cytosine-C5-)-methyltransferase activity [Evidence IDA,IGI,IMP] [PMID 23913415]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0070475 - rRNA base methylation [Evidence IDA,IGI,IMP] [PMID 23913415]
Essential protein involved in mtDNA inheritance; may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 12702300]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 12702300]
similar to AA sequence:KEGG_Orthology:K12590
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01873
Mitochondrial and cytoplasmic valyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 3275649]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3275649]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004832 - valine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004832 - valine-tRNA ligase activity [Evidence ISS] [PMID 3294828]; GO_function: GO:0004832 - valine-tRNA ligase activity [Evidence IDA] [PMID 782885]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006438 - valyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006438 - valyl-tRNA aminoacylation [Evidence IDA] [PMID 782885]
Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10982841]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence IDA] [PMID 10982841]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IDA,TAS] [PMID 10982841]
similar to AA sequence:KEGG_Orthology:K14780
similar to AA sequence:KEGG_Orthology:K03142
Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 7891722]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11766
Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 12052880]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12346
Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IDA] [PMID 11027260]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IDA] [PMID 10574989]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006877 - cellular cobalt ion homeostasis [Evidence IGI] [PMID 9115231]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 11602606]; GO_process: GO:0006824 - cobalt ion transport [Evidence IGI] [PMID 9115231]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 11602606]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03252
eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3); involved in the assembly of preinitiation complex and start codon selection; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 1332047]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IEA]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]; GO_process: GO:0006413 - translational initiation [Evidence IGI,IMP] [PMID 9722586]
similar to AA sequence:KEGG_Orthology:K06699
Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12973301]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15778719]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22908043]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 15778719]; GO_component: GO:0005839 - proteasome core complex [Evidence IDA,IMP] [PMID 15778719]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 23982732]; GO_function: GO:0016504 - peptidase activator activity [Evidence IDA] [PMID 22025621]; GO_function: GO:0070628 - proteasome binding [Evidence IDA,IMP] [PMID 22025621]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 12973301]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17911101]; GO_process: GO:1990236 - proteasome core complex import into nucleus [Evidence IMP] [PMID 23982732]; GO_process: GO:0061136 - regulation of proteasomal protein catabolic process [Evidence IDA] [PMID 22025621]; GO_process: GO:1990237 - sequestration of proteasome core complex in proteasome storage granule [Evidence IMP] [PMID 23982732]
Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 12408816]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 12408816]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]
similar to AA sequence:KEGG_Orthology:K06215
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004359 - glutaminase activity [Evidence IDA] [PMID 14764090]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042823 - pyridoxal phosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IEA]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IMP] [PMID 12271461]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IMP] [PMID 14764090]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IMP] [PMID 12271461]
similar to AA sequence:KEGG_Orthology:K02865
Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 16611745]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16611745]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 12407105]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 12407105]; GO_process: GO:0005979 - regulation of glycogen biosynthetic process [Evidence IGI] [PMID 11602261]; GO_process: GO:0005981 - regulation of glycogen catabolic process [Evidence IGI] [PMID 11602261]; GO_process: GO:0031647 - regulation of protein stability [Evidence IMP] [PMID 16611745]
Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16717099]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0015230 - FAD transmembrane transporter activity [Evidence IMP] [PMID 16717099]; GO_process: GO:0015883 - FAD transport [Evidence IMP] [PMID 16717099]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 16717099]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 16717099]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01697
Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IEA,IEA]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IMP] [PMID 10509018]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IDA] [PMID 10766767]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IDA] [PMID 11948191]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IDA] [PMID 19264153]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IMP] [PMID 8366024]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IDA] [PMID 11948191]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IEA]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IMP] [PMID 10509018]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IMP] [PMID 8366024]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IDA] [PMID 19531479]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 8366024]; GO_process: GO:0007089 - traversing start control point of mitotic cell cycle [Evidence IMP] [PMID 22438835]
glutamyl-tRNA(Gln) amidotransferase subunit PET112
similar to AA sequence:KEGG_Orthology:K02434
Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IEA]; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IDA] [PMID 19417106]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19417106]; GO_component: GO:0005739 - mitochondrion [Evidence IGI] [PMID 9287027]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA,IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 19417106]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IEA]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IDA] [PMID 19417106]; GO_process: GO:0032543 - mitochondrial translation [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 8082172]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00759
Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003999 - adenine phosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003999 - adenine phosphoribosyltransferase activity [Evidence IDA] [PMID 9864350]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006167 - AMP biosynthetic process [Evidence TAS] [PMID 9357956]; GO_process: GO:0044209 - AMP salvage [Evidence IEA]; GO_process: GO:0006168 - adenine salvage [Evidence IEA]; GO_process: GO:0006168 - adenine salvage [Evidence IMP] [PMID 9864350]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006166 - purine ribonucleoside salvage [Evidence IEA]
TFIIH complex serine/threonine-protein kinase subunit KIN28
similar to AA sequence:KEGG_Orthology:K02202
Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 11839796]; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008353 - RNA polymerase II carboxy-terminal domain kinase activity [Evidence IEA]; GO_function: GO:0008353 - RNA polymerase II carboxy-terminal domain kinase activity [Evidence IDA] [PMID 7760796]; GO_function: GO:0008353 - RNA polymerase II carboxy-terminal domain kinase activity [Evidence IDA,IMP] [PMID 9702190]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0019912 - cyclin-dependent protein kinase activating kinase activity [Evidence IDA,IMP] [PMID 7760796]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IMP] [PMID 22689984]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11839796]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 7760796]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA,IMP] [PMID 9702190]; GO_process: GO:1901921 - phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP,IPI] [PMID 10594013]; GO_process: GO:1900018 - phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 10594013]; GO_process: GO:1900018 - phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 19666497]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 14749387]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IMP] [PMID 12015980]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7760796]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7783209]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12669
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence IMP] [PMID 7622558]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IMP] [PMID 7622558]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI] [PMID 22492205]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 10358084]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 7622558]
SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants; GO_component: GO:0044697 - HICS complex [Evidence IPI] [PMID 22623719]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 21498574]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 21498574]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI] [PMID 22956544]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI,IPI] [PMID 19528296]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04043
Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7935837]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14517234]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14638855]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 11096111]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 10464305]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_process: GO:0032079 - positive regulation of endodeoxyribonuclease activity [Evidence IDA] [PMID 10464305]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 10779357]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IDA] [PMID 8654364]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 16460754]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9973563]; GO_process: GO:0043335 - protein unfolding [Evidence IMP] [PMID 8408192]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15371
NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004352 - glutamate dehydrogenase (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004352 - glutamate dehydrogenase (NAD+) activity [Evidence IMP,ISS] [PMID 1975578]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0019551 - glutamate catabolic process to 2-oxoglutarate [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IMP] [PMID 1975578]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17553781]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IGI] [PMID 17553781]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 17681937]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IGI] [PMID 17553781]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IGI] [PMID 17553781]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14794
Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14729571]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 12067653]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence TAS] [PMID 12067653]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence TAS] [PMID 12067653]
putative type II inositol 1,4,5-trisphosphate 5-phosphatase
similar to AA sequence:KEGG_Orthology:K17255
GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005093 - Rab GDP-dissociation inhibitor activity [Evidence IEA]; GO_function: GO:0005093 - Rab GDP-dissociation inhibitor activity [Evidence IDA] [PMID 8157010]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 8157010]
similar to AA sequence:KEGG_Orthology:K18725
Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; homologous to human NUP210; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 9988776]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 7559775]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 8138573]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 9988776]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 10684247]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA,IPI] [PMID 19414609]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 7559775]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 7559775]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IC] [PMID 10684247]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI] [PMID 19414609]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 8138573]; GO_process: GO:0006606 - protein import into nucleus [Evidence IDA] [PMID 7559775]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IGI] [PMID 20713690]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K19308
Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24335083]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0070042 - rRNA (uridine-N3-)-methyltransferase activity [Evidence IMP] [PMID 24335083]; GO_process: GO:0070475 - rRNA base methylation [Evidence IMP] [PMID 24335083]
similar to AA sequence:KEGG_Orthology:K10570
Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 8830695]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI] [PMID 8830695]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17887
Intermediate filament protein; required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence TAS] [PMID 9245780]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005882 - intermediate filament [Evidence TAS] [PMID 9891785]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence TAS] [PMID 9891785]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IDA] [PMID 9245780]; GO_process: GO:0007005 - mitochondrion organization [Evidence TAS] [PMID 9891785]; GO_process: GO:0007097 - nuclear migration [Evidence TAS] [PMID 9891785]; GO_process: GO:0038032 - termination of G-protein coupled receptor signaling pathway [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02677
Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11545731]; GO_component: GO:0005856 - cytoskeleton [Evidence IDA] [PMID 15910746]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11545731]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0032165 - prospore septin filament array [Evidence IDA] [PMID 24390141]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 10893184]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IDA] [PMID 8207005]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IGI] [PMID 12810699]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 21163942]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IMP] [PMID 7874200]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8207005]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 7874200]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP] [PMID 21163942]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 7874200]
similar to AA sequence:KEGG_Orthology:K14311
Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044611 - nuclear pore inner ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 16361228]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 8682855]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 18258809]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI,IMP] [PMID 8682855]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 16361228]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
H(+)-transporting V1 sector ATPase subunit D
similar to AA sequence:KEGG_Orthology:K02149
Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11717306]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
bifunctional urea carboxylase/allophanate hydrolase
similar to AA sequence:KEGG_Orthology:K14541
Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IMP] [PMID 6105114]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IMP] [PMID 6105114]; GO_process: GO:0000256 - allantoin catabolic process [Evidence TAS] [PMID 1938916]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IMP] [PMID 6105114]
phosphopantothenoylcysteine decarboxylase complex subunit CAB3
similar to AA sequence:KEGG_Orthology:K01598
Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0071513 - phosphopantothenoylcysteine decarboxylase complex [Evidence IDA] [PMID 19915539]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence ISS] [PMID 14690591]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence IDA,IMP] [PMID 19915539]; GO_function: GO:0017076 - purine nucleotide binding [Evidence ISS] [PMID 7705654]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 10592175]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 14690591]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]; GO_process: GO:0009651 - response to salt stress [Evidence IGI] [PMID 8923737]
similar to AA sequence:KEGG_Orthology:K15028
similar to AA sequence:KEGG_Orthology:K14951
Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19182805]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10438
C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0000249 - C-22 sterol desaturase activity [Evidence IDA] [PMID 8543054]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8543054]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8635732]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
similar to AA sequence:KEGG_Orthology:K18798
Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 17430883]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17430883]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 17430883]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 19118449]
similar to AA sequence:KEGG_Orthology:K00074
similar to AA sequence:KEGG_Orthology:K01210
Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 7875558]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IEA]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IDA] [PMID 7875558]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IC] [PMID 7875558]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09291
Myosin-like protein associated with the nuclear envelope; connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 10085285]; GO_component: GO:0005643 - nuclear pore [Evidence IEA]; GO_component: GO:0044615 - nuclear pore nuclear basket [Evidence IDA] [PMID 24152732]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 10085285]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IPI] [PMID 15692572]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16027220]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IGI,IPI] [PMID 15692572]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:1901925 - negative regulation of protein import into nucleus during spindle assembly checkpoint [Evidence IGI] [PMID 23177738]; GO_process: GO:0071048 - nuclear retention of unspliced pre-mRNA at the site of transcription [Evidence IGI,IMP] [PMID 14718167]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 21036941]; GO_process: GO:0006606 - protein import into nucleus [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 10085285]; GO_process: GO:0090204 - protein localization to nuclear pore [Evidence IMP] [PMID 19933151]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IGI] [PMID 10638763]; GO_process: GO:0090203 - transcriptional activation by promoter-terminator looping [Evidence IMP] [PMID 19933151]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05285
Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10069808]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 12023081]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 10514566]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 16704983]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 17311586]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0015867 - ATP transport [Evidence IDA] [PMID 12807869]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IDA] [PMID 12023081]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 16704983]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 17311586]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
putative sphingosine kinase-like protein
weak similarity to sphingosine kinase/eukaryotic diacylglycerol kinase involved in Protein Kinase C activation; similar to C terminus of predicted N. crassa protein (NCU06337.1); allele of CaO19.12149
similar to AA sequence:KEGG_Orthology:K14849
Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 3549696]
Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 10788431]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 19496824]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IMP] [PMID 10652283]; GO_function: GO:0005427 - proton-dependent oligopeptide secondary active transmembrane transporter activity [Evidence IDA] [PMID 16149917]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA] [PMID 16149917]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IEP] [PMID 11862495]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_function: GO:0045462 - trichothecene 3-O-acetyltransferase activity [Evidence IMP] [PMID 12478589]; GO_process: GO:0043387 - mycotoxin catabolic process [Evidence IMP] [PMID 12478589]
similar to AA sequence:KEGG_Orthology:K11971
Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006449 - regulation of translational termination [Evidence IMP] [PMID 11570975]
similar to AA sequence:KEGG_Orthology:K12821
U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 15020406]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8622699]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 8622699]
similar to AA sequence:KEGG_Orthology:K11843
Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 12408819]; GO_component: GO:0005838 - proteasome regulatory particle [Evidence IPI] [PMID 11029046]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 12408819]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 17018280]; GO_process: GO:1901799 - negative regulation of proteasomal protein catabolic process [Evidence IMP] [PMID 17018280]; GO_process: GO:0016579 - protein deubiquitination [Evidence IMP] [PMID 12408819]; GO_process: GO:0016579 - protein deubiquitination [Evidence IGI] [PMID 14581483]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17788
Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21944719]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21987634]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 22009199]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0044284 - mitochondrial crista junction [Evidence IDA] [PMID 22009199]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21944719]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21987634]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 22009199]
similar to AA sequence:KEGG_Orthology:K17676
similar to AA sequence:KEGG_Orthology:K13953
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3550419]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3550419]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 3546317]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006113 - fermentation [Evidence ISS] [PMID 3550419]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K08488
DNA-directed DNA polymerase alpha catalytic subunit POL1
similar to AA sequence:KEGG_Orthology:K02320
Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 15773893]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 1704371]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 3888995]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 3907855]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0001882 - nucleoside binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 2651896]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IBA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IC] [PMID 3888995]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IBA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IBA]; GO_process: GO:0000731 - DNA synthesis involved in DNA repair [Evidence IMP] [PMID 2651896]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IDA] [PMID 17429354]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 10025407]; GO_process: GO:0000734 - gene conversion at mating-type locus, DNA repair synthesis [Evidence IBA]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IMP] [PMID 2651896]
similar to AA sequence:KEGG_Orthology:K03695
Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8413229]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 11734006]; GO_function: GO:0051787 - misfolded protein binding [Evidence IDA] [PMID 7628444]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 7628444]; GO_process: GO:0034605 - cellular response to heat [Evidence IGI,IMP] [PMID 8830768]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 7500331]; GO_process: GO:0042026 - protein refolding [Evidence IDA,IMP] [PMID 11734006]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 16460754]; GO_process: GO:0050821 - protein stabilization [Evidence IGI] [PMID 7628444]; GO_process: GO:0043335 - protein unfolding [Evidence IMP] [PMID 16460754]; GO_process: GO:0006950 - response to stress [Evidence IEA]
pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23019326]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10821185]; GO_process: GO:0071469 - cellular response to alkalinity [Evidence IMP] [PMID 23019326]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI,IMP] [PMID 16524906]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10821185]
similar to AA sequence:KEGG_Orthology:K05535
Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9756928]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9756928]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9756928]
similar to AA sequence:KEGG_Orthology:K13239
Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 9813046]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 9837886]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004165 - dodecenoyl-CoA delta-isomerase activity [Evidence IEA]; GO_function: GO:0004165 - dodecenoyl-CoA delta-isomerase activity [Evidence IDA,IMP] [PMID 9813046]; GO_function: GO:0004165 - dodecenoyl-CoA delta-isomerase activity [Evidence IDA,IMP] [PMID 9837886]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IDA] [PMID 9813046]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IDA] [PMID 9837886]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
hexaprenyldihydroxybenzoate methyltransferase
similar to AA sequence:KEGG_Orthology:K00591
O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10760477]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008425 - 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Evidence IEA]; GO_function: GO:0061543 - 3-demethylubiquinone-6 3-O-methyltransferase activity [Evidence IMP] [PMID 10419476]; GO_function: GO:0008689 - 3-demethylubiquinone-9 3-O-methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IMP] [PMID 1885593]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IDA] [PMID 10419476]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 1885593]
similar to AA sequence:KEGG_Orthology:K12198
Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 12940986]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 18032584]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02564
similar to AA sequence:KEGG_Orthology:K00830
Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008453 - alanine-glyoxylate transaminase activity [Evidence IEA]; GO_function: GO:0008453 - alanine-glyoxylate transaminase activity [Evidence IMP] [PMID 14745783]; GO_function: GO:0008453 - alanine-glyoxylate transaminase activity [Evidence IDA] [PMID 16226833]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IEA]; GO_process: GO:0019265 - glycine biosynthetic process, by transamination of glyoxylate [Evidence IDA] [PMID 16226833]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01613
Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005795 - Golgi stack [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 20016005]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IGI] [PMID 14660568]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA] [PMID 6427211]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
bifunctional AAA family ATPase chaperone/translocase BCS1
similar to AA sequence:KEGG_Orthology:K08900
Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8599931]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 1327750]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008320 - protein transmembrane transporter activity [Evidence IMP] [PMID 22017868]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IMP,IPI] [PMID 10508156]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 22017868]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP,IPI] [PMID 22017868]
similar to AA sequence:KEGG_Orthology:K11849
Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1429680]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 1429680]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 24069405]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 15933713]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA,IMP] [PMID 24069405]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IGI,IMP,IPI] [PMID 19165343]
similar to AA sequence:KEGG_Orthology:K15620
Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 18410729]; GO_component: GO:0032580 - Golgi cisterna membrane [Evidence IEA]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 22553352]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18410729]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 18635803]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019899 - enzyme binding [Evidence IPI] [PMID 18410729]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA,IMP] [PMID 20026658]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 16582425]; GO_process: GO:0034067 - protein localization to Golgi apparatus [Evidence IMP] [PMID 18410729]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0060304 - regulation of phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 22553352]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 18635803]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11273
Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome; GO_component: GO:0000790 - nuclear chromatin [Evidence IMP] [PMID 24086532]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10931920]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15020404]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IMP,ISS] [PMID 10931920]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0034085 - establishment of sister chromatid cohesion [Evidence IMP] [PMID 23334284]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP,IPI] [PMID 15020404]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 17483413]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14309
Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3546317]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 3546317]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IDA] [PMID 3546317]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11880
Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17634286]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI,ISS] [PMID 17431397]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 17634286]
similar to AA sequence:KEGG_Orthology:K06883
Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15082539]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 21844196]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 21844196]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 21532343]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IDA] [PMID 21844196]
conserved protein (fungal and bacterial)
similar to AA sequence:KEGG_Orthology:K09704
similar to AA sequence:KEGG_Orthology:K10751
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, and chromatin dynamics during transcription; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0033186 - CAF-1 complex [Evidence IDA] [PMID 9030687]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 11782447]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 16503640]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IDA,IMP] [PMID 9030687]
similar to AA sequence:KEGG_Orthology:K06100
putative WD repeat-containing protein alr3466
Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI,IPI] [PMID 23318452]; GO_process: GO:0006413 - translational initiation [Evidence IGI,IPI] [PMID 23318452]
similar to AA sequence:KEGG_Orthology:K14022
Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 9388185]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 23665229]; GO_function: GO:0097027 - ubiquitin-protein transferase activator activity [Evidence IDA] [PMID 18321851]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9388185]; GO_process: GO:0097051 - establishment of protein localization to endoplasmic reticulum membrane [Evidence IMP] [PMID 9388185]
bifunctional thymidylate/uridylate kinase
similar to AA sequence:KEGG_Orthology:K00943
Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 6094555]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 6094555]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004798 - thymidylate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004798 - thymidylate kinase activity [Evidence IDA] [PMID 6088527]; GO_function: GO:0004798 - thymidylate kinase activity [Evidence IDA] [PMID 6094555]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0009041 - uridylate kinase activity [Evidence IDA] [PMID 6094555]; GO_process: GO:0006233 - dTDP biosynthetic process [Evidence IEA]; GO_process: GO:0006233 - dTDP biosynthetic process [Evidence IDA] [PMID 6094555]; GO_process: GO:0006235 - dTTP biosynthetic process [Evidence IEA]; GO_process: GO:0006235 - dTTP biosynthetic process [Evidence IDA] [PMID 6094555]; GO_process: GO:0006227 - dUDP biosynthetic process [Evidence IDA] [PMID 6094555]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
Monoglyceride lipase (MGL); functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 20554061]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 20554061]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0047372 - acylglycerol lipase activity [Evidence IEA]; GO_function: GO:0047372 - acylglycerol lipase activity [Evidence IMP] [PMID 20554061]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017171 - serine hydrolase activity [Evidence IDA,ISM] [PMID 14645503]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IEA]; GO_process: GO:0006641 - triglyceride metabolic process [Evidence IMP] [PMID 20554061]
similar to AA sequence:KEGG_Orthology:K06640
similar to AA sequence:KEGG_Orthology:K02543
similar to AA sequence:KEGG_Orthology:K03255
Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IPI] [PMID 10358023]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0048312 - intracellular distribution of mitochondria [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 9601101]; GO_process: GO:0006413 - translational initiation [Evidence IPI] [PMID 10358023]
mitochondrial 54S ribosomal protein YmL24/YmL14
similar to AA sequence:KEGG_Orthology:K02902
Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05864
Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9191025]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 10942767]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 9191025]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10942767]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA,IPI] [PMID 9927435]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 10942767]
similar to AA sequence:KEGG_Orthology:K11805
Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0016591 - DNA-directed RNA polymerase II, holoenzyme [Evidence IPI] [PMID 16554755]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19679657]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21504834]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19679657]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21504834]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 21504834]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 21504834]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:1990022 - RNA polymerase III complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 21504834]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12562
Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10393809]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16239147]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 10393809]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI,ISS] [PMID 10388809]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20610658]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20610658]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IPI] [PMID 15802519]
Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11784867]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9219339]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IGI,IMP] [PMID 11784867]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 11784867]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 18675371]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11533229]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 18675371]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 16055745]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11533229]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16055745]; GO_process: GO:0035969 - positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 11208779]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
cytoskeletal protein-binding protein SLA1
similar to AA sequence:KEGG_Orthology:K06634
Cyclin associated with protein kinase Kin28p; Kin28p is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; GO_component: GO:0070985 - TFIIK complex [Evidence IEA]; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 11839796]; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IEA]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IGI,IPI] [PMID 8230216]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11839796]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
hypothetical protein; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K14790
Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 17956976]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17956976]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 17956976]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17956976]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17956976]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17956976]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17956976]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 17956976]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog; GO_component: GO:0032133 - chromosome passenger complex [Evidence IDA] [PMID 19158380]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IGI,IPI] [PMID 10557299]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16608876]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16608876]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 16381814]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 16381814]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16608876]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 10557299]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 16381814]; GO_process: GO:0031134 - sister chromatid biorientation [Evidence IMP] [PMID 19528231]; GO_process: GO:0071173 - spindle assembly checkpoint [Evidence IMP] [PMID 22908045]
similar to AA sequence:KEGG_Orthology:K17974
PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence ISS] [PMID 11101532]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15024427]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21685478]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IGI] [PMID 11101532]
similar to AA sequence:KEGG_Orthology:K02355
Mitochondrial elongation factor involved in translational elongation; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 1935960]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence ISA] [PMID 1935960]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1935960]; GO_process: GO:0070125 - mitochondrial translational elongation [Evidence ISA] [PMID 1935960]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11824
Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IMP] [PMID 10564262]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 19458192]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IC] [PMID 10564262]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06997
Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 11030653]; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 23237950]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11030653]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17234190]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23237950]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 19453974]; GO_process: GO:0090158 - endoplasmic reticulum membrane organization [Evidence IGI] [PMID 23237950]; GO_process: GO:0072659 - protein localization to plasma membrane [Evidence IMP] [PMID 24416406]; GO_process: GO:0060304 - regulation of phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 23237950]
DNA-directed DNA polymerase alpha subunit POL12
similar to AA sequence:KEGG_Orthology:K02321
B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8289832]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 1704371]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 3888995]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 8289832]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]; GO_process: GO:0016233 - telomere capping [Evidence IGI,IMP,IPI] [PMID 15132993]
similar to AA sequence:KEGG_Orthology:K14663
Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0008418 - protein-N-terminal asparagine amidohydrolase activity [Evidence IDA] [PMID 23218487]; GO_function: GO:0008418 - protein-N-terminal asparagine amidohydrolase activity [Evidence IDA,IMP] [PMID 7744855]; GO_function: GO:0070773 - protein-N-terminal glutamine amidohydrolase activity [Evidence IDA] [PMID 23218487]; GO_function: GO:0070773 - protein-N-terminal glutamine amidohydrolase activity [Evidence IMP] [PMID 7744855]; GO_process: GO:0006464 - cellular protein modification process [Evidence IMP] [PMID 7744855]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IMP] [PMID 7744855]
similar to AA sequence:KEGG_Orthology:K11090
RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11720288]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 11720288]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10564276]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 7799435]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 19749380]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9150139]
Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 23169667]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015326 - cationic amino acid transmembrane transporter activity [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0034488 - basic amino acid transmembrane export from vacuole [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02975
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]
similar to AA sequence:KEGG_Orthology:K14855
WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16221974]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 16221974]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06072
Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019135 - deoxyhypusine monooxygenase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0019135 - deoxyhypusine monooxygenase activity [Evidence IDA,IMP] [PMID 16371467]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IGI,IMP] [PMID 14767070]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IEA,IEA,IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IDA,IMP] [PMID 16371467]
similar to AA sequence:KEGG_Orthology:K09497
Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
similar to AA sequence:KEGG_Orthology:K16948
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 3316985]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 18552279]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14993234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9442111]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IMP] [PMID 10882120]; GO_process: GO:0045860 - positive regulation of protein kinase activity [Evidence IDA] [PMID 14527412]; GO_process: GO:0000921 - septin ring assembly [Evidence IDA] [PMID 12636916]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 14993234]
similar to AA sequence:KEGG_Orthology:K03025
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 1400451]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00384
Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18406344]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 18406344]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004791 - thioredoxin-disulfide reductase activity [Evidence IEA,IEA]; GO_function: GO:0004791 - thioredoxin-disulfide reductase activity [Evidence IDA] [PMID 7961686]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 9571241]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0019430 - removal of superoxide radicals [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08956
Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0005745 - m-AAA complex [Evidence IDA] [PMID 8681382]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 19019989]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7929327]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7929327]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IMP] [PMID 8681382]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 19748354]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 8681382]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence TAS] [PMID 12417197]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 8681382]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 12417197]
similar to AA sequence:KEGG_Orthology:K14455
Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9288922]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA,IMP] [PMID 9288922]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 1859361]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IMP] [PMID 9288922]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 15780654]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 9288922]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]
mitochondrial mRNA processing protein Cox24 (predicted)
Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; required for proper actin organization; also localizes to plasma membrane and sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to the TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22593206]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10679030]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22593206]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22593206]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10679030]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 22593206]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22593206]; GO_component: GO:0000133 - polarisome [Evidence IDA] [PMID 16166638]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA] [PMID 10559187]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,IMP] [PMID 22593206]; GO_process: GO:0032858 - activation of Rab GTPase activity [Evidence IDA] [PMID 22593206]; GO_process: GO:0006897 - endocytosis [Evidence IMP,IPI] [PMID 22593206]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 12913108]; GO_process: GO:0070649 - formin-nucleated actin cable assembly [Evidence IGI,IPI] [PMID 16166638]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IMP] [PMID 22593206]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP,IPI] [PMID 22593206]
D-lactate dehydrogenase; located in the mitochondrial matrix; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10509019]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 10509019]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IMP,IPI] [PMID 15158445]; GO_function: GO:0003779 - actin binding [Evidence IPI] [PMID 7719850]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence TAS] [PMID 10509019]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14315
Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 9864355]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 10684247]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA,IPI] [PMID 19414609]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9864355]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IC] [PMID 10684247]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI,IMP] [PMID 15075274]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI,IMP] [PMID 16682526]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 9864355]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IMP] [PMID 15075274]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IMP] [PMID 8349727]; GO_process: GO:0006810 - transport [Evidence IEA]
Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 16314430]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16314430]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 17041589]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 16314430]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IMP] [PMID 17041589]; GO_process: GO:0006810 - transport [Evidence IEA]
Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10739
Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005662 - DNA replication factor A complex [Evidence IDA] [PMID 2554144]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IMP] [PMID 14702040]; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 9679065]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 7761422]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 7761422]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 8804316]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 9093844]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 9093844]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 22885009]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 2554144]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IGI] [PMID 9679065]; GO_process: GO:0045184 - establishment of protein localization [Evidence IMP] [PMID 14702040]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 12226081]; GO_process: GO:0006312 - mitotic recombination [Evidence IPI] [PMID 2554144]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IDA,IMP] [PMID 8910442]; GO_process: GO:0016567 - protein ubiquitination [Evidence IPI] [PMID 18342608]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IPI] [PMID 2554144]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IPI] [PMID 2554144]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 14702040]; GO_process: GO:0010833 - telomere maintenance via telomere lengthening [Evidence IMP] [PMID 22354040]
similar to AA sequence:KEGG_Orthology:K15710
similar to AA sequence:KEGG_Orthology:K00223
C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10722850]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000246 - delta24(24-1) sterol reductase activity [Evidence IEA]; GO_function: GO:0000246 - delta24(24-1) sterol reductase activity [Evidence IDA] [PMID 14922]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016628 - oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8125337]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14765
Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0030532 - small nuclear ribonucleoprotein complex [Evidence TAS] [PMID 10690410]; GO_component: GO:0005732 - small nucleolar ribonucleoprotein complex [Evidence TAS] [PMID 10690410]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9814757]; GO_process: GO:0000154 - rRNA modification [Evidence TAS] [PMID 10690410]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14842
Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16861225]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16861225]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16861225]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
ATP-binding cassette alpha-factor transporter STE6
similar to AA sequence:KEGG_Orthology:K05658
Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8045256]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12374868]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 7679674]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7679674]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 11389139]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 8626301]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000770 - peptide pheromone export [Evidence IMP] [PMID 2569166]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Forkhead transcription factor; drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20847055]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19159085]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20847055]; GO_component: GO:0005667 - transcription factor complex [Evidence IBA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003705 - RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IBA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IMP] [PMID 9920414]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008134 - transcription factor binding [Evidence IBA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 20847055]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 20847055]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8441413]; GO_process: GO:0051090 - regulation of sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0051300 - spindle pole body organization [Evidence IGI] [PMID 9920414]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08139
Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]