Sugiyamaella lignohabitans strain CBS 10342 chromosome A, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Trichomonascaceae; Sugiyamaella.
Complete genome sequence and transcriptome regulation of the pentose utilising yeast Sugiyamaella lignohabitans
Submitted (25-OCT-2016) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (18-FEB-2016) Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, Vienna 1190, Austria
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP014501.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17218313]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 8335627]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015204 - urea transmembrane transporter activity [Evidence IMP,ISS] [PMID 8335627]; GO_process: GO:0015847 - putrescine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEP] [PMID 8335627]; GO_process: GO:0015840 - urea transport [Evidence IMP,ISS] [PMID 8335627]
similar to AA sequence:KEGG_Orthology:K14407
Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 17684230]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 15215336]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03145
General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9334234]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 6985606]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 8876173]; GO_function: GO:0001012 - RNA polymerase II regulatory region DNA binding [Evidence IDA] [PMID 15767671]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IMP] [PMID 15767671]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 12692127]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 9712888]; GO_process: GO:0001193 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14531857]; GO_process: GO:0001193 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 16492753]; GO_process: GO:0001193 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 17535246]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA,IMP] [PMID 17913884]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 8876173]; GO_process: GO:0032784 - regulation of DNA-templated transcription, elongation [Evidence IEA]; GO_process: GO:0031440 - regulation of mRNA 3'-end processing [Evidence IGI,IMP] [PMID 15531585]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 18628399]; GO_process: GO:0031564 - transcription antitermination [Evidence IDA] [PMID 8636112]; GO_process: GO:0031564 - transcription antitermination [Evidence IDA] [PMID 9037112]; GO_process: GO:0031564 - transcription antitermination [Evidence IDA] [PMID 9169440]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 7002153]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 7002153]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 7020755]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 8288647]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 9334234]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IDA] [PMID 18628399]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 15767671]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA,IGI,IMP] [PMID 17901206]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K13343
Central component of the peroxisomal protein import machinery; peroxisomal membrane peroxin; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9094717]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9312008]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 9094717]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 9312008]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IEA]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IMP,IPI] [PMID 16107331]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9094717]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9312008]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
alpha-aminoadipate reductase phosphopantetheinyl transferase Lys7
similar to AA sequence:KEGG_Orthology:K15118
similar to AA sequence:KEGG_Orthology:K03386
Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,ISS] [PMID 10681558]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10821871]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA,IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA] [PMID 10821871]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IMP] [PMID 19332553]
Fungal Genetics Stock Center 12450; Fungal Genetics Stock Center 12449
similar to AA sequence:KEGG_Orthology:K00698
Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9008706]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IMP] [PMID 9760183]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 1293886]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence TAS] [PMID 7565410]
proteasome regulatory particle base subunit RPN1
similar to AA sequence:KEGG_Orthology:K03028
Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0000502 - proteasome complex [Evidence IEA,IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence TAS] [PMID 8982460]; GO_function: GO:0004175 - endopeptidase activity [Evidence TAS] [PMID 9697412]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12198498]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12200120]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0042176 - regulation of protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
similar to AA sequence:KEGG_Orthology:K01282
Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 2647766]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0008239 - dipeptidyl-peptidase activity [Evidence IDA] [PMID 2647766]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA,IEA]; GO_process: GO:0016485 - protein processing [Evidence ISS] [PMID 3305478]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
mitogen-activated serine/threonine-protein kinase SLT2
similar to AA sequence:KEGG_Orthology:K04464
Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, cell cycle progression, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site (PAS); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog, KDX1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12361575]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23924898]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 23924898]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23924898]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence ISS] [PMID 8386319]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 20823268]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 24554767]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 18971375]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI] [PMID 19633265]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IDA,IMP] [PMID 16380504]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI] [PMID 16524906]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 14703512]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 20219973]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 8386319]; GO_process: GO:0042990 - regulation of transcription factor import into nucleus [Evidence IMP] [PMID 20219973]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16087742]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 8386319]
DNA-directed RNA polymerase core subunit RPB8
similar to AA sequence:KEGG_Orthology:K03016
RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IPI] [PMID 11486042]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IPI] [PMID 11486042]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IPI] [PMID 11486042]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IGI] [PMID 9927738]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
mitochondrial 54S ribosomal protein YmL25
similar to AA sequence:KEGG_Orthology:K17438
Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
similar to AA sequence:KEGG_Orthology:K11087
Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9012791]; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720285]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 8430095]
similar to AA sequence:KEGG_Orthology:K01930
Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10775416]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10775416]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004326 - tetrahydrofolylpolyglutamate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004326 - tetrahydrofolylpolyglutamate synthase activity [Evidence IDA] [PMID 10775416]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IMP] [PMID 10775416]; GO_process: GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10862
Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12206772]; GO_function: GO:0017005 - 3'-tyrosyl-DNA phosphodiesterase activity [Evidence IDA] [PMID 10521354]; GO_function: GO:0070260 - 5'-tyrosyl-DNA phosphodiesterase activity [Evidence IDA] [PMID 16751265]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 10521354]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15135727]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12097146]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12097146]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 12097146]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 12097146]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI] [PMID 17417630]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IGI] [PMID 16615892]
anaphase promoting complex subunit CDC27
similar to AA sequence:KEGG_Orthology:K03350
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 8895471]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP] [PMID 16481473]
similar to AA sequence:KEGG_Orthology:K17086
Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI] [PMID 20681974]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
similar to AA sequence:KEGG_Orthology:K00122
NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11921099]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IGI,ISS] [PMID 11921099]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 21246355]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 11921099]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 19564482]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17869212]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17937657]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0070178 - D-serine metabolic process [Evidence IMP] [PMID 17937657]
similar to AA sequence:KEGG_Orthology:K14649
TFIID subunit (65 kDa); involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00102
D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9525904]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IMP,ISS] [PMID 8492799]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8492799]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K04523
Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 8070654]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 11805328]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15167887]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IGI] [PMID 8070654]
similar to AA sequence:KEGG_Orthology:K14832
Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein; GO_component: GO:0030690 - Noc1p-Noc2p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23209026]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 9786894]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 23209026]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06647
Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 8314797]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20681974]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI,IMP] [PMID 20681974]; GO_process: GO:0016197 - endosomal transport [Evidence IMP] [PMID 20526336]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 23986483]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IDA] [PMID 23129774]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 20375281]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 16874038]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20375281]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10727015]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 23129774]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 16079147]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 16874038]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20375281]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 8619313]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 16079147]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 16874038]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0034497 - protein localization to pre-autophagosomal structure [Evidence IMP] [PMID 20375281]; GO_process: GO:0034497 - protein localization to pre-autophagosomal structure [Evidence IMP] [PMID 23129774]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IMP] [PMID 16079147]
trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1
similar to AA sequence:KEGG_Orthology:K13939
Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8813764]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 15169867]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003848 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0003848 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [Evidence IDA] [PMID 15169867]; GO_function: GO:0003848 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [Evidence ISS] [PMID 9234673]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004150 - dihydroneopterin aldolase activity [Evidence IEA,IEA]; GO_function: GO:0004150 - dihydroneopterin aldolase activity [Evidence ISS] [PMID 11752249]; GO_function: GO:0004150 - dihydroneopterin aldolase activity [Evidence IDA] [PMID 15169867]; GO_function: GO:0004156 - dihydropteroate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004156 - dihydropteroate synthase activity [Evidence IMP] [PMID 11731153]; GO_function: GO:0004156 - dihydropteroate synthase activity [Evidence IDA] [PMID 15169867]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006760 - folic acid-containing compound metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0042558 - pteridine-containing compound metabolic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IMP] [PMID 11731153]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IMP] [PMID 15169867]
Basic leucine zipper (bZIP) transcription factor; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9372930]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 9372930]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9372930]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08157
Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AMP-activated serine/threonine-protein kinase catalytic subunit SNF1
similar to AA sequence:KEGG_Orthology:K12761
AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ubiquitin ligase; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA] [PMID 12393914]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA,IPI] [PMID 2481228]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 9121458]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 11331606]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17237508]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IPI] [PMID 11331606]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 17237508]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11331606]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17237508]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 11486005]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 2557546]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 7913470]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 11486005]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 2557546]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 7913470]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0042710 - biofilm formation [Evidence IMP] [PMID 12024013]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007155 - cell adhesion [Evidence IMP] [PMID 12556493]; GO_process: GO:0006995 - cellular response to nitrogen starvation [Evidence IDA] [PMID 12024013]; GO_process: GO:0071940 - fungal-type cell wall assembly [Evidence IMP] [PMID 24486034]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 11095711]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12556493]; GO_process: GO:0017148 - negative regulation of translation [Evidence IGI,IMP] [PMID 18955495]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:1900436 - positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [Evidence IMP] [PMID 22904036]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP] [PMID 8628258]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP] [PMID 8710504]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP] [PMID 9111319]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 11486005]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 12024013]; GO_process: GO:0006109 - regulation of carbohydrate metabolic process [Evidence IGI,IPI] [PMID 12167649]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI,IMP] [PMID 10921902]
similar to AA sequence:KEGG_Orthology:K11121
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12242223]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 7498786]; GO_function: GO:0070403 - NAD+ binding [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 16815704]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 7498786]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16815704]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046459 - short-chain fatty acid metabolic process [Evidence IMP] [PMID 12618394]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
similar to AA sequence:KEGG_Orthology:K09527
Nuclear type II J heat shock protein of the E. coli dnaJ family; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; GO_component: GO:0005634 - nucleus [Evidence TAS] [PMID 15170475]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 8045411]; GO_process: GO:0006457 - protein folding [Evidence ISS] [PMID 8045411]
similar to AA sequence:KEGG_Orthology:K02218
Mitochondrial intermembrane space protein; involved in phospholipid metabolism; has role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 19506038]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 19506038]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IGI] [PMID 19506038]; GO_process: GO:0042407 - cristae formation [Evidence IGI,IMP] [PMID 19221197]; GO_process: GO:2001246 - negative regulation of phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 22403410]; GO_process: GO:0046337 - phosphatidylethanolamine metabolic process [Evidence IGI,IMP] [PMID 19221197]
similar to AA sequence:KEGG_Orthology:K01893
Mitochondrial asparaginyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 9030748]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IDA] [PMID 9030748]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IDA] [PMID 9030748]; GO_process: GO:0070145 - mitochondrial asparaginyl-tRNA aminoacylation [Evidence IMP] [PMID 9030748]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13333
Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0042597 - periplasmic space [Evidence IDA] [PMID 8051052]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8051052]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IMP] [PMID 8051052]; GO_function: GO:0004620 - phospholipase activity [Evidence IEA]; GO_process: GO:0006650 - glycerophospholipid metabolic process [Evidence IMP] [PMID 8051052]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0036151 - phosphatidylcholine acyl-chain remodeling [Evidence IMP] [PMID 23501167]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
17-beta-hydroxysteroid dehydrogenase-like protein
Putative glycoside hydrolase of the mitochondrial intermembrane space; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17065
Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 20841380]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15550248]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 16520372]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 8299420]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 15265985]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 20841380]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20841380]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0016559 - peroxisome fission [Evidence IMP] [PMID 18445678]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8299420]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 8299420]
similar to AA sequence:KEGG_Orthology:K05747
Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments and a polyproline domain which can nucleate actin filaments independent of Arp2/3; mutants are defective in actin cytoskeleton dependent processes such as: endocytosis, bud site selection and cytokinesis; localizes with the Arp2/3 complex to actin cortical patches; homolog of the Wiskott-Aldrich Syndrome protein (WASP), implicated in severe immunodeficiency; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10512884]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9024694]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 10512884]; GO_function: GO:0003779 - actin binding [Evidence IDA,IPI] [PMID 23290554]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 18177206]; GO_process: GO:0007015 - actin filament organization [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IDA] [PMID 9214384]; GO_process: GO:0030041 - actin filament polymerization [Evidence IDA] [PMID 22973053]; GO_process: GO:0045010 - actin nucleation [Evidence IDA] [PMID 23290554]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation [Evidence IEA]; GO_process: GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA] [PMID 10322115]; GO_process: GO:0032233 - positive regulation of actin filament bundle assembly [Evidence IDA] [PMID 19158382]
similar to AA sequence:KEGG_Orthology:K12606
Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 11733989]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 11733989]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14758
similar to AA sequence:KEGG_Orthology:K03426
NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 11361135]; GO_function: GO:0000210 - NAD+ diphosphatase activity [Evidence IEA]; GO_function: GO:0000210 - NAD+ diphosphatase activity [Evidence IDA] [PMID 11361135]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006734 - NADH metabolic process [Evidence IDA] [PMID 11361135]
1-phosphatidylinositol-4-phosphate 5-kinase
similar to AA sequence:KEGG_Orthology:K00889
Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01069
Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9261170]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004416 - hydroxyacylglutathione hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004416 - hydroxyacylglutathione hydrolase activity [Evidence IDA,IGI,IMP] [PMID 9261170]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IEA]; GO_process: GO:0019243 - methylglyoxal catabolic process to D-lactate [Evidence IDA,IGI,IMP] [PMID 9261170]
glycerophosphoryl diester phosphodiesterase (predicted)
similar to AA sequence:KEGG_Orthology:K09540
Ubiquitin-binding protein; contains a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; CUE5 has a paralog, DON1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12628920]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K14284
Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0042272 - nuclear RNA export factor complex [Evidence IPI] [PMID 9774696]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12524544]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12411502]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 10722667]; GO_process: GO:0051028 - mRNA transport [Evidence IEA,IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 17434126]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 22956913]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09831
C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0000249 - C-22 sterol desaturase activity [Evidence IDA] [PMID 8543054]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8543054]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8635732]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08284
N-glycosylated integral membrane protein of the ER and plasma membrane; functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14729456]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IMP] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IMP] [PMID 9343395]; GO_function: GO:0015275 - stretch-activated, cation-selective, calcium channel activity [Evidence IDA] [PMID 10436155]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA] [PMID 10958666]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03177
Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype); GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 9358157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 9358157]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IGI] [PMID 9358157]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 9358157]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0031211 - endoplasmic reticulum palmitoyltransferase complex [Evidence IPI] [PMID 12193598]; GO_component: GO:0042406 - extrinsic component of endoplasmic reticulum membrane [Evidence IDA] [PMID 12379641]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IDA] [PMID 12193598]; GO_process: GO:0018345 - protein palmitoylation [Evidence IDA] [PMID 12193598]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16751107]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 7532279]
Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis; GO_component: GO:0016021 - integral component of membrane [Evidence IBA,IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11251115]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IRD]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 23509072]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence IBA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence ISA] [PMID 11251115]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IDA] [PMID 23509072]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090374 - oligopeptide export from mitochondrion [Evidence ISA] [PMID 11251115]; GO_process: GO:0006857 - oligopeptide transport [Evidence ISA] [PMID 11251115]; GO_process: GO:0055085 - transmembrane transport [Evidence IBA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 2203793]; GO_function: GO:1901235 - (R)-carnitine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 2203793]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_function: GO:0034228 - ethanolamine transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_process: GO:1900749 - (R)-carnitine transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015871 - choline transport [Evidence IMP] [PMID 2203793]; GO_process: GO:0015871 - choline transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0034229 - ethanolamine transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0031460 - glycine betaine transport [Evidence IMP] [PMID 16487344]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23047103]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IGI,IMP] [PMID 23047103]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962064]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16962064]
similar to AA sequence:KEGG_Orthology:K00773
similar to AA sequence:KEGG_Orthology:K01641
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004421 - hydroxymethylglutaryl-CoA synthase activity [Evidence IEA,IEA]; GO_function: GO:0004421 - hydroxymethylglutaryl-CoA synthase activity [Evidence IMP] [PMID 6148937]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 6148937]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 19506040]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 19506040]
Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15071
F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15537705]; GO_component: GO:0051286 - cell tip [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15537705]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 11287615]; GO_function: GO:0000149 - SNARE binding [Evidence IMP,IPI] [PMID 11287615]; GO_function: GO:0000149 - SNARE binding [Evidence IPI] [PMID 15537705]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 15537705]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 24272750]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 10769031]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048278 - vesicle docking [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17583
Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia; GO_component: GO:0097078 - FAl1-SGD1 complex [Evidence IPI] [PMID 21576267]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11042259]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA,ISS] [PMID 11042259]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 11042259]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 12073033]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]
putative pantetheine-phosphate adenylyltransferase
similar to AA sequence:KEGG_Orthology:K02201
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004595 - pantetheine-phosphate adenylyltransferase activity [Evidence IEA]; GO_function: GO:0004595 - pantetheine-phosphate adenylyltransferase activity [Evidence ISS] [PMID 11923312]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 11923312]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]
similar to AA sequence:KEGG_Orthology:K13100
Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 20956557]; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 20956557]
similar to AA sequence:KEGG_Orthology:K00382
Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication; GO_component: GO:0005960 - glycine cleavage complex [Evidence IMP] [PMID 7498764]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004148 - dihydrolipoyl dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004148 - dihydrolipoyl dehydrogenase activity [Evidence IDA] [PMID 2821168]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IMP] [PMID 7498764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016668 - oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Evidence IEA]; GO_function: GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity [Evidence IMP] [PMID 3528755]; GO_function: GO:0004738 - pyruvate dehydrogenase activity [Evidence IMP] [PMID 3528755]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence IMP] [PMID 3528755]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IMP] [PMID 7498764]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IMP] [PMID 7498764]; GO_process: GO:0042743 - hydrogen peroxide metabolic process [Evidence IGI,IMP] [PMID 17110466]; GO_process: GO:0006550 - isoleucine catabolic process [Evidence IMP] [PMID 1479341]; GO_process: GO:0006552 - leucine catabolic process [Evidence IMP] [PMID 1479341]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 3528755]; GO_process: GO:0006574 - valine catabolic process [Evidence IMP] [PMID 1479341]
similar to AA sequence:KEGG_Orthology:K04482
Strand exchange protein; forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 9427283]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 11459983]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 8066464]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0000150 - recombinase activity [Evidence IDA] [PMID 8066464]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 20371520]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006259 - DNA metabolic process [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IDA] [PMID 22955832]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0045002 - double-strand break repair via single-strand annealing [Evidence IMP] [PMID 8849880]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 10506208]; GO_process: GO:0000709 - meiotic joint molecule formation [Evidence IMP] [PMID 1581961]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 16581767]; GO_process: GO:0042148 - strand invasion [Evidence IDA] [PMID 8066464]; GO_process: GO:0042148 - strand invasion [Evidence IDA] [PMID 9271413]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IMP] [PMID 11238918]
similar to AA sequence:KEGG_Orthology:K01183
Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11747810]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 1918080]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 1918080]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11914276]; GO_function: GO:0008061 - chitin binding [Evidence IEA]; GO_function: GO:0004568 - chitinase activity [Evidence IEA,IEA]; GO_function: GO:0008843 - endochitinase activity [Evidence IDA] [PMID 6799506]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IC] [PMID 3033651]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 1918080]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]
Arf family guanine nucleotide exchange factor SEC7
similar to AA sequence:KEGG_Orthology:K18442
similar to AA sequence:KEGG_Orthology:K02735
Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0061133 - endopeptidase activator activity [Evidence IGI] [PMID 9207060]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain; GO_component: GO:0031932 - TORC2 complex [Evidence IEA]; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_process: GO:0031929 - TOR signaling [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 15809876]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 15809876]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IGI] [PMID 9804843]
similar to AA sequence:KEGG_Orthology:K07562
Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10022925]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 10022925]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 11105761]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 17347149]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11086007]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI] [PMID 23212245]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14559
Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034457 - Mpp10 complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0032040 - small-subunit processome [Evidence IMP] [PMID 12242301]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9315638]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9315638]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9315638]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning Dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA,IPI] [PMID 7947791]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA,IMP] [PMID 2007123]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA,IMP] [PMID 2007123]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03380
similar to AA sequence:KEGG_Orthology:K12373
similar to AA sequence:KEGG_Orthology:K02257
Heme A:farnesyltransferase; catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0008495 - protoheme IX farnesyltransferase activity [Evidence IEA]; GO_function: GO:0008495 - protoheme IX farnesyltransferase activity [Evidence ISS] [PMID 8118433]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0048034 - heme O biosynthetic process [Evidence IEA]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IMP] [PMID 8118433]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00252
phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
similar to AA sequence:KEGG_Orthology:K01106
Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11094088]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11094088]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9560389]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IMP] [PMID 9438131]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 10224048]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9438131]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
inositol polyphosphate phosphatase (predicted)
similar to AA sequence:KEGG_Orthology:K08486
Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19502581]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 19502581]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IPI] [PMID 7954793]; GO_function: GO:0070300 - phosphatidic acid binding [Evidence IDA] [PMID 19502581]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence TAS] [PMID 10047442]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence TAS] [PMID 10047442]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01810
Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004347 - glucose-6-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004347 - glucose-6-phosphate isomerase activity [Evidence IMP] [PMID 3007940]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 3020369]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 3007940]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 7901008]
putative serine/threonine protein kinase KSP1
Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10899124]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IMP] [PMID 12549926]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 9786867]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 22128164]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 14517251]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA,IMP] [PMID 16720702]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 22128164]; GO_process: GO:0034225 - regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [Evidence IMP] [PMID 9271382]; GO_process: GO:0034225 - regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [Evidence IMP] [PMID 9786867]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18466
Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IMP] [PMID 9700157]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01739
hypothetical protein with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence ISS] [PMID 10821189]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence ISS] [PMID 10821189]
similar to AA sequence:KEGG_Orthology:K03320
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11069679]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9482721]; GO_process: GO:0006810 - transport [Evidence IEA]
putative peroxisomal copper amine oxidase
similar to AA sequence:KEGG_Orthology:K00276
one of two likely peroxisomal copper amine oxidase genes; similar to A.niger AO-I; allele of CaO19.10662
similar to AA sequence:KEGG_Orthology:K05531
Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 16034811]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 10037752]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8991513]
similar to AA sequence:KEGG_Orthology:K05528
Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 9434768]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence ISS] [PMID 9653120]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence TAS] [PMID 10037752]; GO_process: GO:0006080 - substituted mannan metabolic process [Evidence TAS] [PMID 10037752]
Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9860978]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IPI] [PMID 11509570]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 9860978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14862
similar to S. cerevisiae URB2 (YJR041C) essential nucleolar protein (Unhealthy Ribosome Biogenesis); allele of CaO19.5884
Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K15463
2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IDA,IGI,IMP] [PMID 7954819]; GO_process: GO:0019988 - charged-tRNA amino acid modification [Evidence IGI,IMP] [PMID 7954819]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14826
Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR4 has a paralog, FPR3, that arose from the whole genome duplication; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 14981505]; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 16959570]; GO_component: GO:0016020 - membrane [Evidence IBA]; GO_component: GO:0005730 - nucleolus [Evidence IBA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14981505]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9371805]; GO_function: GO:0005528 - FK506 binding [Evidence IBA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0005527 - macrolide binding [Evidence IDA] [PMID 9371805]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 14981505]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 16959570]; GO_process: GO:0000412 - histone peptidyl-prolyl isomerization [Evidence IEA]; GO_process: GO:0000412 - histone peptidyl-prolyl isomerization [Evidence IDA] [PMID 16959570]; GO_process: GO:0000415 - negative regulation of histone H3-K36 methylation [Evidence IMP] [PMID 16959570]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 16846601]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 24297734]; GO_process: GO:0018208 - peptidyl-proline modification [Evidence IBA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16959570]
similar to AA sequence:KEGG_Orthology:K15292
Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10427089]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11038189]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10427089]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11038189]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15466482]; GO_function: GO:0000149 - SNARE binding [Evidence IDA] [PMID 10427089]; GO_process: GO:0006887 - exocytosis [Evidence IMP,IPI] [PMID 10427089]; GO_process: GO:0031340 - positive regulation of vesicle fusion [Evidence IDA] [PMID 15466482]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IPI] [PMID 10427089]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15174
Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 9032243]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15149594]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 11983171]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 16581788]; GO_function: GO:0000983 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 16581788]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 16581788]; GO_function: GO:0001089 - TFIIF-class binding transcription factor activity [Evidence IMP,IPI] [PMID 9032243]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11983171]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 16582434]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21737840]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IMP] [PMID 9891041]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15180994]; GO_process: GO:2001255 - positive regulation of histone H3-K36 trimethylation [Evidence IMP] [PMID 17948059]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20299458]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 12667454]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 18194564]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:2001166 - regulation of histone H2B ubiquitination [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12667454]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 15180994]; GO_process: GO:2001163 - regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 15149594]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 18194564]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11884586]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10219085]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 16246725]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IDA,IMP] [PMID 16246725]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 19164765]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11927560]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IGI,IMP] [PMID 20299458]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15111
S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14609944]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000095 - S-adenosyl-L-methionine transmembrane transporter activity [Evidence IDA,IGI,IMP] [PMID 14609944]; GO_process: GO:0015805 - S-adenosyl-L-methionine transport [Evidence IDA,IGI,IMP] [PMID 14609944]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04487
Cysteine desulfurase; involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria; GO_component: GO:1990221 - L-cysteine desulfurase complex [Evidence IPI] [PMID 24045011]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10406803]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19720832]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 11110795]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19720832]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0031071 - cysteine desulfurase activity [Evidence IEA,IEA]; GO_function: GO:0031071 - cysteine desulfurase activity [Evidence IDA] [PMID 12065597]; GO_function: GO:0031071 - cysteine desulfurase activity [Evidence IDA] [PMID 15220327]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 10551871]; GO_process: GO:0006534 - cysteine metabolic process [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12970193]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 15220327]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0070903 - mitochondrial tRNA thio-modification [Evidence IMP] [PMID 14722066]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IMP] [PMID 14722066]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IMP] [PMID 15220327]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K18852
Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence ISS] [PMID 10600387]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 10600387]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence ISS] [PMID 10600387]; GO_process: GO:0051289 - protein homotetramerization [Evidence IDA] [PMID 10600387]
similar to AA sequence:KEGG_Orthology:K02181
Component of the GTPase-activating Bfa1p-Bub2p complex; involved in multiple cell cycle checkpoint pathways that control exit from mitosis; specifically required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 10220406]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 15147270]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 16682821]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI,IMP] [PMID 16039591]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IMP] [PMID 15147270]
similar to AA sequence:KEGG_Orthology:K10398
Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 1618910]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IGI] [PMID 1618910]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007019 - microtubule depolymerization [Evidence IMP] [PMID 19041752]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 9813090]; GO_process: GO:0030541 - plasmid partitioning [Evidence IMP] [PMID 19364922]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 9813090]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618897]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618910]
similar to AA sequence:KEGG_Orthology:K06134
Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9452453]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence ISS] [PMID 11435415]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9452453]
similar to AA sequence:KEGG_Orthology:K08054
Protein involved in bud-site selection; required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12972503]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 7730410]; GO_function: GO:0005089 - Rho guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 2065354]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0032319 - regulation of Rho GTPase activity [Evidence IEA]; GO_process: GO:0035023 - regulation of Rho protein signal transduction [Evidence IEA]
Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 10377429]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 15623581]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 15623581]; GO_process: GO:0034394 - protein localization to cell surface [Evidence IGI,IMP] [PMID 10377429]
similar to AA sequence:KEGG_Orthology:K12830
Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport; GO_component: GO:0005686 - U2 snRNP [Evidence IPI] [PMID 10369685]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0030620 - U2 snRNA binding [Evidence IPI] [PMID 10369685]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI,IMP] [PMID 9819400]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IDA] [PMID 10369685]
Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 10409731]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043200 - response to amino acid [Evidence IMP] [PMID 10409731]
hypothetical protein; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K06911
glucose-inactivated glycerol proton symporter STL1
Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 21347277]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11389843]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 17483413]
similar to AA sequence:KEGG_Orthology:K10875
DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 12399378]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 10506208]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 10506208]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032392 - DNA geometric change [Evidence IDA] [PMID 10506208]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 12577053]; GO_process: GO:0045002 - double-strand break repair via single-strand annealing [Evidence IMP] [PMID 8849880]; GO_process: GO:0045003 - double-strand break repair via synthesis-dependent strand annealing [Evidence TAS] [PMID 10357855]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 10506208]; GO_process: GO:0032079 - positive regulation of endodeoxyribonuclease activity [Evidence IDA] [PMID 19129197]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IMP] [PMID 11238918]
trifunctional fatty acid synthase subunit FAS2
similar to AA sequence:KEGG_Orthology:K00667
Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 6025308]; GO_component: GO:0005835 - fatty acid synthase complex [Evidence IDA] [PMID 65153]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004316 - 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0004316 - 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [Evidence IDA] [PMID 365179]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence IEA]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IGI] [PMID 10785388]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IMP] [PMID 65153]; GO_function: GO:0004321 - fatty-acyl-CoA synthase activity [Evidence IEA]; GO_function: GO:0008897 - holo-[acyl-carrier-protein] synthase activity [Evidence IEA]; GO_function: GO:0008897 - holo-[acyl-carrier-protein] synthase activity [Evidence IGI,IMP] [PMID 10785388]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 1735446]; GO_process: GO:0009059 - macromolecule biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05290
ER membrane glycoprotein subunit of the GPI transamidase complex; adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 11598210]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8978684]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IMP] [PMID 10793132]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IMP] [PMID 11598210]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 11598210]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17677
Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10322435]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21211725]
High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K19200
similar to AA sequence:KEGG_Orthology:K02835
Mitochondrial translation release factor; involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 1475194]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 8265342]; GO_function: GO:0003747 - translation release factor activity [Evidence IEA]; GO_function: GO:0003747 - translation release factor activity [Evidence IDA] [PMID 10748224]; GO_function: GO:0003747 - translation release factor activity [Evidence IGI] [PMID 1475194]; GO_function: GO:0016149 - translation release factor activity, codon specific [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 14734569]; GO_process: GO:0070126 - mitochondrial translational termination [Evidence IGI] [PMID 1475194]; GO_process: GO:0070126 - mitochondrial translational termination [Evidence IMP] [PMID 15827612]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 1475194]
similar to AA sequence:KEGG_Orthology:K11427
similar to AA sequence:KEGG_Orthology:K05286
Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol (GPI) core structure; human PIG-Bp is a functional homolog; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9639537]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004584 - dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity [Evidence IMP] [PMID 9576863]; GO_function: GO:0004584 - dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity [Evidence IMP] [PMID 9639537]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 9759715]
similar to AA sequence:KEGG_Orthology:K03648
Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11812822]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24034606]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11812822]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24034606]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016799 - hydrolase activity, hydrolyzing N-glycosyl compounds [Evidence IEA]; GO_function: GO:0004844 - uracil DNA N-glycosylase activity [Evidence IEA,IEA]; GO_function: GO:0004844 - uracil DNA N-glycosylase activity [Evidence IDA] [PMID 2644266]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 1938887]; GO_process: GO:0006284 - base-excision repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17798
Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 11604502]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 11604502]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 11604502]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IGI,IPI] [PMID 11950926]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IPI] [PMID 17452441]
similar to AA sequence:KEGG_Orthology:K11786
similar to AA sequence:KEGG_Orthology:K11665
ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 10361278]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA,IMP] [PMID 10952318]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 10952318]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 23207916]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 18258182]; GO_process: GO:0043486 - histone exchange [Evidence IDA] [PMID 21241891]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IMP] [PMID 17681272]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 21135121]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17681272]; GO_process: GO:0051983 - regulation of chromosome segregation [Evidence IMP] [PMID 23207916]; GO_process: GO:0043618 - regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 19620280]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IGI] [PMID 23390378]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 10952318]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0035529 - NADH pyrophosphatase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IGI,IMP] [PMID 16278456]; GO_function: GO:0047429 - nucleoside-triphosphate diphosphatase activity [Evidence IDA,IGI,IMP] [PMID 16278456]; GO_function: GO:0004551 - nucleotide diphosphatase activity [Evidence IEA]; GO_function: GO:0004551 - nucleotide diphosphatase activity [Evidence ISS] [PMID 16278456]; GO_function: GO:0004528 - phosphodiesterase I activity [Evidence IEA]; GO_function: GO:0004528 - phosphodiesterase I activity [Evidence ISS] [PMID 16278456]; GO_process: GO:0016036 - cellular response to phosphate starvation [Evidence IEP,IMP] [PMID 16278456]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0009141 - nucleoside triphosphate metabolic process [Evidence IMP] [PMID 16278456]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence ISS] [PMID 16278456]
putative indolepyruvate decarboxylase family protein
similar to AA sequence:KEGG_Orthology:K12261
hypothetical protein with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0033106 - cis-Golgi network membrane [Evidence IDA] [PMID 9564032]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 11102533]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 17041589]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 17110339]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 17287728]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 8590804]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 8590804]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00869
Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0004496 - mevalonate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004496 - mevalonate kinase activity [Evidence IDA] [PMID 16477420]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01951
GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003922 - GMP synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0003922 - GMP synthase (glutamine-hydrolyzing) activity [Evidence IMP,ISS] [PMID 8112582]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IEA]; GO_process: GO:0006177 - GMP biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006177 - GMP biosynthetic process [Evidence IMP] [PMID 20980241]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]
bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
similar to AA sequence:KEGG_Orthology:K05955
Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (RAM2-RAM1 heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (RAM2-CDC43 heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor; GO_component: GO:0005953 - CAAX-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 1400380]; GO_component: GO:0005965 - protein farnesyltransferase complex [Evidence IDA] [PMID 1763050]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IEA]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IDA] [PMID 1400380]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IDA] [PMID 1763050]; GO_function: GO:0004661 - protein geranylgeranyltransferase activity [Evidence IDA] [PMID 2034682]; GO_function: GO:0008318 - protein prenyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IDA] [PMID 1763050]; GO_process: GO:0018343 - protein farnesylation [Evidence IDA] [PMID 1763050]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IDA] [PMID 1400380]; GO_process: GO:0018342 - protein prenylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17989
Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006565 - L-serine catabolic process [Evidence IGI] [PMID 7042346]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006567 - threonine catabolic process [Evidence IGI] [PMID 7042346]
similar to AA sequence:KEGG_Orthology:K06943
Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11112701]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16861225]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 11112701]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12773575]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 16888624]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17443350]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP,IPI] [PMID 12773575]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Putative zinc finger protein; YPR013C is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 23012409]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0008150 - biological_process [Evidence ND]
mannosyltransferase complex subunit MNN9
similar to AA sequence:KEGG_Orthology:K05529
Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 9430634]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 19249370]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 9430634]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA] [PMID 19249370]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA] [PMID 9430634]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8862519]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 8862519]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8862519]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8862519]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IGI,IMP] [PMID 8862519]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16850348]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 10869563]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10869563]
similar to AA sequence:KEGG_Orthology:K11322
Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0032777 - Piccolo NuA4 histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0032777 - Piccolo NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 12782659]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 10911987]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 17274630]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 15610740]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 22539722]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 10911987]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03233
Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12824466]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 8465602]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 8465602]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IMP] [PMID 12824466]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12824466]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IGI] [PMID 8041634]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K06681
Actin- and formin-interacting protein; participates in actin cable assembly and organization as a nucleation-promoting factor (NPF) for formins Bni1p and Bnr1p; a triple helical coiled-coil domain in the C-terminal region interacts with Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11071900]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23671312]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9247651]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11071900]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 23671312]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9247651]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11071900]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9247651]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9082982]; GO_component: GO:0000133 - polarisome [Evidence IDA] [PMID 9632790]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 17416900]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 7719850]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 9247651]; GO_function: GO:0005519 - cytoskeletal regulatory protein binding [Evidence IPI] [PMID 15923184]; GO_function: GO:0005519 - cytoskeletal regulatory protein binding [Evidence IDA] [PMID 9082982]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 23671312]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI,IMP] [PMID 23671312]; GO_process: GO:0030953 - astral microtubule organization [Evidence IMP] [PMID 22608510]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 8657162]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 9247651]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 10866679]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 9247651]; GO_process: GO:0034652 - extrachromosomal circular DNA localization involved in cell aging [Evidence IMP] [PMID 18660802]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IGI,IMP] [PMID 17237521]; GO_process: GO:0090338 - positive regulation of formin-nucleated actin cable assembly [Evidence IDA,IGI] [PMID 14657240]; GO_process: GO:0090338 - positive regulation of formin-nucleated actin cable assembly [Evidence IDA] [PMID 15923184]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10085294]
similar to AA sequence:KEGG_Orthology:K11126
Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12101098]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12101098]; GO_component: GO:0000333 - telomerase catalytic core complex [Evidence IDA,IPI] [PMID 15813705]; GO_component: GO:0005697 - telomerase holoenzyme complex [Evidence IDA,IPI] [PMID 10898986]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003720 - telomerase activity [Evidence IDA] [PMID 15813705]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 17656141]; GO_function: GO:0003721 - telomeric template RNA reverse transcriptase activity [Evidence IEA]; GO_function: GO:0003721 - telomeric template RNA reverse transcriptase activity [Evidence TAS] [PMID 11884619]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI] [PMID 18627461]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IDA,IMP] [PMID 15813705]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 8978029]
similar to AA sequence:KEGG_Orthology:K11770
Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 9154831]; GO_component: GO:0000228 - nuclear chromosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 9154831]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0031055 - chromatin remodeling at centromere [Evidence IMP] [PMID 12697820]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 12697820]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16024655]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0033262 - regulation of nuclear cell cycle DNA replication [Evidence IGI] [PMID 17542652]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 11309124]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 19820940]; GO_process: GO:0010969 - regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 19820940]
similar to AA sequence:KEGG_Orthology:K11339
Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 11036083]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 11036083]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 11036083]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16286007]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IMP] [PMID 21248844]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IMP] [PMID 16364921]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 19417103]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11036083]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 19948887]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00486
Kynurenine 3-mono oxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004502 - kynurenine 3-monooxygenase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004502 - kynurenine 3-monooxygenase activity [Evidence IMP] [PMID 15806102]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA]; GO_process: GO:0043420 - anthranilate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0019805 - quinolinate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11324
Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15353583]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 12672825]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 14690591]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IPI] [PMID 12672825]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 14690608]; GO_process: GO:0051276 - chromosome organization [Evidence IMP] [PMID 18439903]; GO_process: GO:0043968 - histone H2A acetylation [Evidence IEA]; GO_process: GO:0043967 - histone H4 acetylation [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 14690591]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14863
Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats; GO_component: GO:0070545 - PeBoW complex [Evidence IDA,IPI] [PMID 16287855]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11583614]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IGI] [PMID 10454593]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
similar to AA sequence:KEGG_Orthology:K00820
Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0004360 - glutamine-fructose-6-phosphate transaminase (isomerizing) activity [Evidence IEA,IEA]; GO_function: GO:0004360 - glutamine-fructose-6-phosphate transaminase (isomerizing) activity [Evidence IDA] [PMID 2656689]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IEA]; GO_process: GO:0016051 - carbohydrate biosynthetic process [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI] [PMID 11895440]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
hypothetical protein with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17053
AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9467951]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 9467951]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 11805329]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 9467951]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 9467951]; GO_function: GO:0052735 - tRNA (cytosine-3-)-methyltransferase activity [Evidence IDA,IMP] [PMID 21518804]; GO_function: GO:0052735 - tRNA (cytosine-3-)-methyltransferase activity [Evidence IDA] [PMID 21518805]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IDA] [PMID 9467951]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 21518804]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 21518805]
Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
top hit is XP_002839470.1 originated in Tuber melanosporum Mel28
similar to AA sequence:KEGG_Orthology:K14834
Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing; GO_component: GO:0030691 - Noc2p-Noc3p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 22421151]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11371346]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 11371346]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12110182]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12110182]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IDA] [PMID 12110182]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 22421151]; GO_process: GO:0006364 - rRNA processing [Evidence IDA] [PMID 12110182]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16572
similar to AA sequence:KEGG_Orthology:K13336
Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16009135]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 1894692]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 23900285]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9418908]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 23900285]; GO_process: GO:0032581 - ER-dependent peroxisome organization [Evidence IDA] [PMID 17646399]; GO_process: GO:0032581 - ER-dependent peroxisome organization [Evidence IMP] [PMID 20427571]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IMP] [PMID 19948495]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0045046 - protein import into peroxisome membrane [Evidence IMP] [PMID 10637226]
8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 10922370]; GO_function: GO:0008413 - 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [Evidence IDA,IMP] [PMID 15475388]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IDA] [PMID 10922370]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15475388]; GO_process: GO:0009132 - nucleoside diphosphate metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08286
similar to AA sequence:KEGG_Orthology:K12562
Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16239147]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 9566960]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 12477802]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI,ISS] [PMID 10388809]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20610658]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 7891662]; GO_process: GO:0031532 - actin cytoskeleton reorganization [Evidence IMP] [PMID 7891662]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 11096097]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20610658]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 1776363]; GO_process: GO:0042594 - response to starvation [Evidence IMP] [PMID 1776363]
similar to AA sequence:KEGG_Orthology:K01626
Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10975256]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9701810]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 7935367]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:2001196 - positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine [Evidence IMP] [PMID 3123231]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 11952910]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3123231]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7935367]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IMP] [PMID 17229886]
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10990452]; GO_component: GO:0000139 - Golgi membrane [Evidence IPI] [PMID 10990452]; GO_component: GO:0034066 - RIC1-RGP1 guanyl-nucleotide exchange factor complex [Evidence IPI] [PMID 10990452]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 10990452]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 10990452]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 10990452]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IMP] [PMID 11082047]
exosome non-catalytic core subunit RRP45
similar to AA sequence:KEGG_Orthology:K03678
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16541108]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00626
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 5571830]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IDA] [PMID 7989303]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
proteasome regulatory particle base subunit RPN10
similar to AA sequence:KEGG_Orthology:K03029
Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IMP] [PMID 15242647]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IPI] [PMID 15907469]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0031593 - polyubiquitin binding [Evidence IDA] [PMID 8887631]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 9741626]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15242647]
mitochondrial 54S ribosomal protein YmL23
similar to AA sequence:KEGG_Orthology:K02871
Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23509072]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00381
Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0009337 - sulfite reductase complex (NADPH) [Evidence IDA] [PMID 6751400]; GO_component: GO:0009337 - sulfite reductase complex (NADPH) [Evidence IDA] [PMID 9003798]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IDA] [PMID 6751400]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 19236486]; GO_process: GO:0000097 - sulfur amino acid biosynthetic process [Evidence IMP] [PMID 1479340]
NADH:ubiquinone oxidoreductase 78kD subunit
similar to AA sequence:KEGG_Orthology:K03934
Neurospora crassa e-Compendium ncu01765.3
similar to AA sequence:KEGG_Orthology:K13237
Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00232
Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11967269]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA,IEA]; GO_function: GO:0003995 - acyl-CoA dehydrogenase activity [Evidence IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence ISA] [PMID 2189786]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence IEA]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence ISA] [PMID 2189786]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
protein geranylgeranyltransferase type I subunit CDC43
similar to AA sequence:KEGG_Orthology:K11713
Beta subunit of geranylgeranyltransferase type I; catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis; GO_component: GO:0005953 - CAAX-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 1400380]; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 9891811]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IEA]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IDA] [PMID 1400380]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0004661 - protein geranylgeranyltransferase activity [Evidence IDA] [PMID 10066831]; GO_function: GO:0004661 - protein geranylgeranyltransferase activity [Evidence IDA] [PMID 2034682]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence TAS] [PMID 9891811]; GO_process: GO:0030010 - establishment of cell polarity [Evidence TAS] [PMID 9891811]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IDA] [PMID 2034682]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence TAS] [PMID 9891811]
similar to AA sequence:KEGG_Orthology:K03685
Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15090619]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15090619]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IDA] [PMID 15766245]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034963 - box C/D snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0034964 - box H/ACA snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 17991894]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IMP] [PMID 17158880]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17991894]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 17991894]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 22576366]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IDA,IMP,IPI] [PMID 19818713]
similar to AA sequence:KEGG_Orthology:K11667
Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 23207916]; GO_process: GO:0051983 - regulation of chromosome segregation [Evidence IMP] [PMID 23207916]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008251 - tRNA-specific adenosine deaminase activity [Evidence IDA] [PMID 10550050]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 10550050]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04565
Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p and enters the nucleus under oxidative stress to promote transcription of stress response genes; human ortholog implicated in ALS; abundance increases under DNA replication stress and during exposure to boric acid; localization of a fraction to the mitochondrial intermembrane space is modulated by the MICOS complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11500508]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 11500508]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18977757]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24647101]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IBA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IEA,IEA]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IDA] [PMID 3290902]; GO_function: GO:0008270 - zinc ion binding [Evidence IBA]; GO_process: GO:0001320 - age-dependent response to reactive oxygen species involved in chronological cell aging [Evidence IMP] [PMID 8647826]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 8530401]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 11581253]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 20176017]; GO_process: GO:1901856 - negative regulation of cellular respiration [Evidence IMP] [PMID 23332757]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0051091 - positive regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 18977757]; GO_process: GO:0036091 - positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [Evidence IMP] [PMID 24647101]; GO_process: GO:0050821 - protein stabilization [Evidence IMP,IPI] [PMID 23332757]; GO_process: GO:0019430 - removal of superoxide radicals [Evidence IBA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IMP] [PMID 3290902]
Rho family guanine nucleotide exchange factor TUS1
Rho family guanine nucleotide exchange factor ROM2
Cytoplasmic hypothetical protein; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K13886
Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA,IPI] [PMID 12499356]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9822583]; GO_component: GO:0005826 - actomyosin contractile ring [Evidence IBA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 9885246]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 9885246]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 9885246]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 18177206]; GO_process: GO:0007015 - actin filament organization [Evidence IMP,IPI] [PMID 9885246]; GO_process: GO:0007017 - microtubule-based process [Evidence IPI] [PMID 9885246]; GO_process: GO:0034316 - negative regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA,IMP] [PMID 12499356]; GO_process: GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA,IMP] [PMID 21454476]
similar to AA sequence:KEGG_Orthology:K00128
Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IMP] [PMID 9675847]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006740 - NADPH regeneration [Evidence IGI] [PMID 19158096]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IGI] [PMID 10919763]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IMP] [PMID 9675847]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 10409655]
similar to AA sequence:KEGG_Orthology:K01886
Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15706032]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15706032]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004819 - glutamine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004819 - glutamine-tRNA ligase activity [Evidence IDA] [PMID 2991203]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006425 - glutaminyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006425 - glutaminyl-tRNA aminoacylation [Evidence IMP,ISS] [PMID 2991203]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K10259
F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 9716410]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043224 - nuclear SCF ubiquitin ligase complex [Evidence IDA] [PMID 10637232]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10637232]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 15870262]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 15870262]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 9716410]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 9716410]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IGI,IPI] [PMID 9499404]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 15870262]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 15870262]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046685 - response to arsenic-containing substance [Evidence IDA] [PMID 15689486]; GO_process: GO:0046686 - response to cadmium ion [Evidence IDA] [PMID 15689486]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14810
DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11565753]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15028736]; GO_function: GO:0033680 - ATP-dependent DNA/RNA helicase activity [Evidence IDA] [PMID 15028736]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 15028736]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11565753]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18097
Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 10818358]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0047953 - glycerol 2-dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:1990042 - glycerol dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 22979944]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Suppressor of sphingoid LCB sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; GO_component: GO:0071944 - cell periphery [Evidence IDA] [PMID 24146988]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12034738]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 12034738]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12034738]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16407254]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IDA,ISS] [PMID 12034738]; GO_process: GO:0015908 - fatty acid transport [Evidence IDA] [PMID 12034738]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 15342785]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23651256]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence ISS] [PMID 10207060]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 23651256]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0009074 - aromatic amino acid family catabolic process [Evidence IMP] [PMID 10207060]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10207060]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006572 - tyrosine catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08178
Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17710650]; GO_function: GO:0015144 - carbohydrate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015355 - secondary active monocarboxylate transmembrane transporter activity [Evidence IMP] [PMID 17710650]; GO_function: GO:0097079 - selenite:proton symporter activity [Evidence IMP] [PMID 20861301]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0034219 - carbohydrate transmembrane transport [Evidence IEA]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 10198029]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0006849 - plasma membrane pyruvate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0097080 - plasma membrane selenite transport [Evidence IMP] [PMID 20861301]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
1-phosphatidylinositol phosphodiesterase
similar to AA sequence:KEGG_Orthology:K01771
phosphoadenylyl-sulfate reductase (thioredoxin)
similar to AA sequence:KEGG_Orthology:K00390
3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 3060034]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004604 - phosphoadenylyl-sulfate reductase (thioredoxin) activity [Evidence IEA,IEA]; GO_function: GO:0004604 - phosphoadenylyl-sulfate reductase (thioredoxin) activity [Evidence IMP] [PMID 2203779]; GO_function: GO:0004604 - phosphoadenylyl-sulfate reductase (thioredoxin) activity [Evidence IDA] [PMID 3060034]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IMP] [PMID 197388]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IDA] [PMID 3060034]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
similar to AA sequence:KEGG_Orthology:K17866
Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA,IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 15485916]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 8406038]
similar to AA sequence:KEGG_Orthology:K10706
Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS; GO_component: GO:0035649 - Nrd1 complex [Evidence IDA] [PMID 16427013]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8544822]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 23141540]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0032575 - ATP-dependent 5'-3' RNA helicase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA,IMP] [PMID 22286094]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23748379]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 11565036]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 22123738]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IMP] [PMID 23141540]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9365256]; GO_process: GO:1990248 - regulation of transcription from RNA polymerase II promoter in response to DNA damage [Evidence IMP] [PMID 23741394]; GO_process: GO:0016180 - snRNA processing [Evidence IMP] [PMID 9365256]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 11565036]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9365256]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 17157256]
Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence TAS] [PMID 11602261]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence TAS] [PMID 11602261]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0005979 - regulation of glycogen biosynthetic process [Evidence IGI] [PMID 11602261]; GO_process: GO:0005981 - regulation of glycogen catabolic process [Evidence IGI] [PMID 11602261]
Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10467108]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10467108]; GO_function: GO:0043531 - ADP binding [Evidence IMP] [PMID 11867765]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 11867765]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IDA,IMP] [PMID 16135516]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IMP] [PMID 9674429]; GO_function: GO:0051087 - chaperone binding [Evidence IDA] [PMID 9674429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16135516]; GO_process: GO:0070370 - cellular heat acclimation [Evidence IMP] [PMID 2188365]; GO_process: GO:0070389 - chaperone cofactor-dependent protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0001319 - inheritance of oxidatively modified proteins involved in replicative cell aging [Evidence IGI,IMP] [PMID 17908928]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IMP] [PMID 10931304]; GO_process: GO:0019538 - protein metabolic process [Evidence IEA]; GO_process: GO:0043335 - protein unfolding [Evidence IMP] [PMID 7984243]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0070414 - trehalose metabolism in response to heat stress [Evidence IMP] [PMID 9797333]
similar to AA sequence:KEGG_Orthology:K03264
Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11238882]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17353896]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11238882]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16188229]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IEA]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 9891075]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238882]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238882]; GO_process: GO:0042256 - mature ribosome assembly [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 17353896]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 10206977]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 11238882]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IEA]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IGI] [PMID 17353896]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K06910
Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IDA] [PMID 11805111]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence ISS] [PMID 9164465]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IDA] [PMID 11805111]
similar to AA sequence:KEGG_Orthology:K02220
similar to AA sequence:KEGG_Orthology:K17867
hypothetical protein; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 22367199]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 15485916]
DNA-directed RNA polymerase I subunit RPA49
similar to AA sequence:KEGG_Orthology:K03005
RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IMP] [PMID 1409638]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 21263028]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 18160037]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 12374750]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 9121426]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 16741702]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8594329]; GO_function: GO:0005352 - alpha-glucoside:proton symporter activity [Evidence IDA] [PMID 12702465]; GO_function: GO:0005364 - maltose:proton symporter activity [Evidence IMP] [PMID 1999393]; GO_function: GO:0005364 - maltose:proton symporter activity [Evidence IMP] [PMID 8594329]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015293 - symporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015574 - trehalose transmembrane transporter activity [Evidence IDA] [PMID 12702465]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0046352 - disaccharide catabolic process [Evidence IMP] [PMID 20562106]; GO_process: GO:0000023 - maltose metabolic process [Evidence IEA]; GO_process: GO:0015768 - maltose transport [Evidence IGI] [PMID 6371820]; GO_process: GO:0015768 - maltose transport [Evidence IMP] [PMID 8594329]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0015771 - trehalose transport [Evidence IDA] [PMID 12702465]
similar to AA sequence:KEGG_Orthology:K12661
similar to AA sequence:KEGG_Orthology:K18338
similar to AA sequence:KEGG_Orthology:K01875
Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IDA] [PMID 3031581]; GO_process: GO:0097056 - selenocysteinyl-tRNA(Sec) biosynthetic process [Evidence IEA]; GO_process: GO:0006434 - seryl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006434 - seryl-tRNA aminoacylation [Evidence IDA] [PMID 3031581]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
hypothetical protein; predicted to contain a PINc domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase
similar to AA sequence:KEGG_Orthology:K11788
Enzyme of the 'de novo' purine nucleotide biosynthetic pathway; contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004637 - phosphoribosylamine-glycine ligase activity [Evidence IEA,IEA]; GO_function: GO:0004637 - phosphoribosylamine-glycine ligase activity [Evidence ISS] [PMID 3097325]; GO_function: GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity [Evidence IEA,IEA]; GO_function: GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity [Evidence ISS] [PMID 3097325]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence TAS] [PMID 9148957]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
DExD/H-box ATP-dependent RNA helicase DHH1
similar to AA sequence:KEGG_Orthology:K12614
Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, role in translational repression, mRNA decay, and processing body dynamics; may have a role in mRNA export; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12032091]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 12730603]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 18611963]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 20368989]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 12930949]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 23706738]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 11780629]; GO_function: GO:0090079 - translation regulator activity, nucleic acid binding [Evidence IGI,IMP] [PMID 22719226]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 18182159]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IGI] [PMID 18981231]; GO_process: GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA [Evidence IMP] [PMID 11780629]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0017148 - negative regulation of translation [Evidence IMP] [PMID 21844211]; GO_process: GO:0045900 - negative regulation of translational elongation [Evidence IGI,IMP] [PMID 22719226]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]; GO_process: GO:0006810 - transport [Evidence IEA]
mitogen-activated protein kinase kinase STE7
similar to AA sequence:KEGG_Orthology:K11226
DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22367945]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 22367945]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 22367945]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K13289
Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
Putative serine type carboxypeptidase; role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0017171 - serine hydrolase activity [Evidence IDA,ISM] [PMID 14645503]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence ISA] [PMID 17408619]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IGI] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI,ISS] [PMID 10564262]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IPI,ISS] [PMID 10564262]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 17003107]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IPI,ISS] [PMID 10564262]
guanine nucleotide-binding protein subunit beta
similar to AA sequence:KEGG_Orthology:K14753
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 15340087]; GO_function: GO:0001965 - G-protein alpha-subunit binding [Evidence IPI] [PMID 17591772]; GO_function: GO:0005092 - GDP-dissociation inhibitor activity [Evidence IDA] [PMID 17591772]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 17591772]; GO_process: GO:0017148 - negative regulation of translation [Evidence IMP] [PMID 15340087]
similar to AA sequence:KEGG_Orthology:K01410
Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8035833]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA,IMP] [PMID 8831696]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IMP] [PMID 10332043]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IMP] [PMID 8035833]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 21525245]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01915
Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004356 - glutamate-ammonia ligase activity [Evidence IEA,IEA]; GO_function: GO:0004356 - glutamate-ammonia ligase activity [Evidence IMP] [PMID 1347768]; GO_function: GO:0004356 - glutamate-ammonia ligase activity [Evidence IDA] [PMID 4156034]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006542 - glutamine biosynthetic process [Evidence IEA]; GO_process: GO:0006542 - glutamine biosynthetic process [Evidence IDA] [PMID 6129248]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IDA] [PMID 19158363]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 19158363]
similar to AA sequence:KEGG_Orthology:K11378
Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 10817755]; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 17157260]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 10817755]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 11731478]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 11731479]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11731479]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 10817755]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01881
Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence ISS] [PMID 10592175]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006433 - prolyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IGI,IPI] [PMID 15024067]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 15024067]
Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 18086897]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 18086897]
3-deoxy-7-phosphoheptulonate synthase ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IDA] [PMID 2880280]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01663
Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 8852895]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004359 - glutaminase activity [Evidence IDA] [PMID 10733892]; GO_function: GO:0000107 - imidazoleglycerol-phosphate synthase activity [Evidence IEA]; GO_function: GO:0000107 - imidazoleglycerol-phosphate synthase activity [Evidence IDA] [PMID 10733892]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016833 - oxo-acid-lyase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 17344218]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0010698 - acetyltransferase activator activity [Evidence IDA,IMP] [PMID 19172749]; GO_function: GO:0042393 - histone binding [Evidence IDA,IPI] [PMID 17344218]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP,IPI] [PMID 18036332]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 17344218]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IDA,IGI,IMP] [PMID 18458063]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
top hit is XP_007844384.1 originated in Moniliophthora roreri MCA 2997
similar to AA sequence:KEGG_Orthology:K09495
Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9294463]; GO_function: GO:0000319 - sulfite transmembrane transporter activity [Evidence IDA] [PMID 10870099]; GO_process: GO:0000316 - sulfite transport [Evidence IDA] [PMID 10870099]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02964
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IBA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14627813]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00856
Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004001 - adenosine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004001 - adenosine kinase activity [Evidence IDA,IMP] [PMID 11223943]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044209 - AMP salvage [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IMP] [PMID 11223943]; GO_process: GO:0006166 - purine ribonucleoside salvage [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00861
Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IDA] [PMID 10887197]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10887197]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003919 - FMN adenylyltransferase activity [Evidence IDA] [PMID 10887197]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008531 - riboflavin kinase activity [Evidence IEA,IEA]; GO_function: GO:0008531 - riboflavin kinase activity [Evidence IDA,IMP] [PMID 10887197]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009398 - FMN biosynthetic process [Evidence IEA]; GO_process: GO:0009398 - FMN biosynthetic process [Evidence IDA,IMP] [PMID 10887197]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18723
mitochondrial 54S ribosomal protein YmL7/YmL5
similar to AA sequence:KEGG_Orthology:K02931
Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17301
Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP); GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IGI,ISS] [PMID 7929113]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030135 - coated vesicle [Evidence ISS] [PMID 7929113]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7929113]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005685 - U1 snRNP [Evidence IEA]; GO_component: GO:0005685 - U1 snRNP [Evidence IGI,IMP] [PMID 10500099]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 17726058]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IGI,IMP] [PMID 10500099]
similar to AA sequence:KEGG_Orthology:K12667
Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IMP] [PMID 9405463]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01705
Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence ISA] [PMID 9268014]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 2507177]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
DEAH-box ATP-dependent RNA helicase PRP22
similar to AA sequence:KEGG_Orthology:K13117
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IMP] [PMID 9524130]; GO_component: GO:0071021 - U2-type post-spliceosomal complex [Evidence IMP] [PMID 12212850]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 9582286]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IDA] [PMID 12212850]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 9524130]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IDA] [PMID 12212850]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000390 - spliceosomal complex disassembly [Evidence IMP] [PMID 9524130]
similar to AA sequence:KEGG_Orthology:K03113
Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 12008673]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 17434125]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 12861028]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 22851688]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 15664195]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 17434125]; GO_process: GO:1990145 - maintenance of translational fidelity [Evidence IMP] [PMID 9488467]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0071561 - nucleus-vacuole junction [Evidence IDA] [PMID 22250200]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 22250200]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K16261
Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:1902274 - positive regulation of (R)-carnitine transmembrane transport [Evidence IMP] [PMID 23755272]; GO_process: GO:1902269 - positive regulation of polyamine transmembrane transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K10632
hypothetical protein required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IDA] [PMID 9497340]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16564012]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0045471 - response to ethanol [Evidence IMP] [PMID 19416103]
ribose phosphate diphosphokinase subunit PRS3
similar to AA sequence:KEGG_Orthology:K00948
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17623
similar to AA sequence:KEGG_Orthology:K07374
Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005874 - microtubule [Evidence IEA,IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005827 - polar microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0043234 - protein complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_component: GO:0045298 - tubulin complex [Evidence IDA,IPI] [PMID 9488492]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IMP] [PMID 16582437]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 16582437]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 16582437]; GO_process: GO:0051258 - protein polymerization [Evidence IEA]
Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IMP] [PMID 15256563]; GO_process: GO:0006068 - ethanol catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00002
NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008106 - alcohol dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:0008106 - alcohol dehydrogenase (NADP+) activity [Evidence IDA] [PMID 11742541]; GO_function: GO:0033833 - hydroxymethylfurfural reductase (NADH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0033845 - hydroxymethylfurfural reductase (NADPH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006066 - alcohol metabolic process [Evidence IDA] [PMID 11742541]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IDA] [PMID 11742541]; GO_process: GO:0033859 - furaldehyde metabolic process [Evidence IMP] [PMID 16652391]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00844
Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004340 - glucokinase activity [Evidence IEA]; GO_function: GO:0004340 - glucokinase activity [Evidence IMP] [PMID 6341351]; GO_function: GO:0004340 - glucokinase activity [Evidence IDA] [PMID 8501032]; GO_function: GO:0004396 - hexokinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA]; GO_process: GO:0051156 - glucose 6-phosphate metabolic process [Evidence IEA]; GO_process: GO:0046323 - glucose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 8501032]; GO_process: GO:0006013 - mannose metabolic process [Evidence IDA] [PMID 237183]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12411
Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 12464633]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA] [PMID 20385087]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IPI] [PMID 12464633]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IMP,IPI] [PMID 20385087]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 12464633]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17314407]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 20797624]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 20797624]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10675505]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20797624]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20797624]; GO_process: GO:0007155 - cell adhesion [Evidence IDA] [PMID 11816034]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 20797624]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IMP] [PMID 20797624]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 20797624]; GO_process: GO:0007009 - plasma membrane organization [Evidence IMP] [PMID 20797624]; GO_process: GO:0006950 - response to stress [Evidence IEA,IEA]
Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 7568152]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 9106207]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 19380492]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IGI] [PMID 7568152]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 8622686]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
hypothetical protein; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9751732]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01527
Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005854 - nascent polypeptide-associated complex [Evidence IDA] [PMID 10219998]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 9482879]; GO_process: GO:0051083 - 'de novo' cotranslational protein folding [Evidence IPI] [PMID 10219998]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IGI] [PMID 10518932]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01580
Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004351 - glutamate decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004351 - glutamate decarboxylase activity [Evidence IMP] [PMID 11031268]; GO_function: GO:0016829 - lyase activity [Evidence IEA,IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11031268]; GO_process: GO:0006538 - glutamate catabolic process [Evidence IMP] [PMID 11031268]; GO_process: GO:0006536 - glutamate metabolic process [Evidence IEA]
Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 16611745]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19218424]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 12101234]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0016242 - negative regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 12101234]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0031647 - regulation of protein stability [Evidence IMP] [PMID 12101234]
Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12553664]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 12553664]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IGI,IMP,IPI] [PMID 12553664]
similar to AA sequence:KEGG_Orthology:K15429
tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17652090]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 17652090]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0052906 - tRNA (guanine(37)-N(1))-methyltransferase activity [Evidence IEA]; GO_function: GO:0016423 - tRNA (guanine) methyltransferase activity [Evidence IGI,IMP,ISS] [PMID 11226173]; GO_function: GO:0009019 - tRNA (guanine-N1-)-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IGI,IMP,ISS] [PMID 11226173]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17803
Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 15355998]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 9873020]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03679
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA,IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8600032]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0071049 - nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [Evidence IGI] [PMID 11586364]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14651
similar to AA sequence:KEGG_Orthology:K18726
Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10; GO_component: GO:0044695 - Dsc E3 ubiquitin ligase complex [Evidence IDA] [PMID 22681890]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K15255
similar to AA sequence:KEGG_Orthology:K03660
Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance; GO_component: GO:0031518 - CBF3 complex [Evidence IDA] [PMID 19882662]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11239005]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11239005]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0008534 - oxidized purine nucleobase lesion DNA N-glycosylase activity [Evidence IEA]; GO_function: GO:0008534 - oxidized purine nucleobase lesion DNA N-glycosylase activity [Evidence IDA] [PMID 8643552]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 11239005]; GO_process: GO:0006284 - base-excision repair [Evidence IEA]; GO_process: GO:0006285 - base-excision repair, AP site formation [Evidence IDA] [PMID 8643552]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IGI] [PMID 19264809]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 19942858]
similar to AA sequence:KEGG_Orthology:K13106
Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids; GO_component: GO:0070274 - RES complex [Evidence IDA] [PMID 15565172]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11452010]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 15565172]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 15565172]
similar to AA sequence:KEGG_Orthology:K12618
similar to AA sequence:KEGG_Orthology:K14307
similar to AA sequence:KEGG_Orthology:K01194
Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IEA,IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence TAS] [PMID 9308367]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IEA]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IMP] [PMID 23597844]; GO_process: GO:0005991 - trehalose metabolic process [Evidence IEA]
hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01493
Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004132 - dCMP deaminase activity [Evidence IEA]; GO_function: GO:0004132 - dCMP deaminase activity [Evidence IMP] [PMID 3023902]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IMP] [PMID 6373725]; GO_process: GO:0006226 - dUMP biosynthetic process [Evidence IMP] [PMID 6373725]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01613
Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology by affecting lipid mixing in the mitochondrial membrane and by influencing the ratio of long to short forms of Mgm1p; partly exposed to the mitochondrial intermembrane space; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 23124206]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IMP] [PMID 8407984]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA] [PMID 6427211]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0010636 - positive regulation of mitochondrial fusion [Evidence IMP] [PMID 23045528]; GO_process: GO:0010954 - positive regulation of protein processing [Evidence IMP] [PMID 23045528]
similar to AA sequence:KEGG_Orthology:K03348
Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IEA]; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008054 - cyclin catabolic process [Evidence IMP] [PMID 8895471]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 8895471]; GO_process: GO:0007091 - metaphase/anaphase transition of mitotic cell cycle [Evidence IMP] [PMID 8895471]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16481473]
similar to AA sequence:KEGG_Orthology:K13367
Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0052904 - N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052903 - N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IMP] [PMID 11154694]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IDA] [PMID 21067138]; GO_function: GO:0052902 - spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052901 - spermine:oxygen oxidoreductase (spermidine-forming) activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006598 - polyamine catabolic process [Evidence IGI,IMP] [PMID 12586697]
similar to AA sequence:KEGG_Orthology:K03349
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0031461 - cullin-RING ubiquitin ligase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008054 - cyclin catabolic process [Evidence IMP] [PMID 9430641]; GO_process: GO:0010458 - exit from mitosis [Evidence IGI] [PMID 9430641]; GO_process: GO:0007091 - metaphase/anaphase transition of mitotic cell cycle [Evidence IGI] [PMID 9430641]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16481473]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11790
similar to AA sequence:KEGG_Orthology:K05355
Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10760477]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000010 - trans-hexaprenyltranstransferase activity [Evidence IMP] [PMID 9708911]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9708911]
similar to AA sequence:KEGG_Orthology:K11778
Cis-prenyltransferase involved in dolichol synthesis; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11442630]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 24868093]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9858571]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0045547 - dehydrodolichyl diphosphate synthase activity [Evidence IDA] [PMID 11442630]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IDA] [PMID 17345630]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IDA] [PMID 9858571]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 12911815]; GO_process: GO:0019408 - dolichol biosynthetic process [Evidence IDA] [PMID 10217761]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IDA,IMP] [PMID 9858571]
similar to AA sequence:KEGG_Orthology:K02868
Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 2277060]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15306
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10825193]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10825193]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IDA] [PMID 7836422]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10991951]; GO_process: GO:0006405 - RNA export from nucleus [Evidence IMP] [PMID 7489726]; GO_process: GO:0046907 - intracellular transport [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 7489726]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10991951]
similar to AA sequence:KEGG_Orthology:K02737
Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 8808631]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9312134]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0080129 - proteasome core complex assembly [Evidence IMP] [PMID 8808631]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15620355]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15692568]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005667 - transcription factor complex [Evidence IBA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003705 - RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_function: GO:0001225 - RNA polymerase II transcription coactivator binding [Evidence IPI] [PMID 15620355]; GO_function: GO:0001226 - RNA polymerase II transcription corepressor binding [Evidence IPI] [PMID 15620355]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IBA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0010688 - negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15620355]; GO_process: GO:0010688 - negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI] [PMID 7785326]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 15616569]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15620355]; GO_process: GO:0051090 - regulation of sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10882
similar to AA sequence:KEGG_Orthology:K06111
Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12960429]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9491896]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12960429]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 7615633]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9491896]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 1512289]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 7615633]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9491896]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0048313 - Golgi inheritance [Evidence IMP] [PMID 15596717]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 15596717]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
ubiquitin-binding serine/threonine protein kinase VPS15
similar to AA sequence:KEGG_Orthology:K08333
top hit is XP_006683298.1 originated in Batrachochytrium dendrobatidis JAM81
stress-responsive transcriptional activator MSN4
similar to AA sequence:KEGG_Orthology:K09468
similar to AA sequence:KEGG_Orthology:K00026
Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9774331]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10777592]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IMP] [PMID 10777592]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IDA] [PMID 1898005]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016615 - malate dehydrogenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3312168]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 3312168]
hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane; GO_component: GO:0005780 - extrinsic component of intraperoxisomal membrane [Evidence IEA]; GO_component: GO:0005780 - extrinsic component of intraperoxisomal membrane [Evidence IDA] [PMID 15928207]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 14562095]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 23900285]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 23900285]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IEA]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IMP,IPI] [PMID 15928207]
similar to AA sequence:KEGG_Orthology:K11518
Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005742 - mitochondrial outer membrane translocase complex [Evidence IDA] [PMID 9774667]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0046930 - pore complex [Evidence IEA]; GO_function: GO:0015288 - porin activity [Evidence IEA]; GO_function: GO:0015266 - protein channel activity [Evidence IEA]; GO_function: GO:0015266 - protein channel activity [Evidence IDA] [PMID 9774109]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 15590639]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
H(+)-transporting V0 sector ATPase subunit a
similar to AA sequence:KEGG_Orthology:K02154
Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11592965]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11948198]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11592965]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IDA,ISS] [PMID 7514599]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IGI,ISS] [PMID 7514599]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IEP,IGI,IMP,ISS] [PMID 11278748]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI] [PMID 7514599]
similar to AA sequence:KEGG_Orthology:K01655
Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9099739]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004410 - homocitrate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004410 - homocitrate synthase activity [Evidence ISS] [PMID 9099739]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IGI,IMP] [PMID 18524920]
similar to AA sequence:KEGG_Orthology:K15192
Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 11880621]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21976730]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9234740]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 22298788]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IPI] [PMID 8083216]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IMP] [PMID 24459134]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17296733]; GO_process: GO:0045898 - regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 15861138]; GO_process: GO:0045898 - regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 21976730]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9234740]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IDA,IMP] [PMID 17296733]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14399
Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IEA,IEA]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 11344258]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IEA,IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IDA] [PMID 11344258]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12871
hypothetical protein involved in calcium homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 23569283]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 23569283]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI,IMP] [PMID 23569283]
similar to AA sequence:KEGG_Orthology:K11426
SET domain hypothetical protein; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]
Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16452144]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 16546083]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0016035 - zeta DNA polymerase complex [Evidence IDA] [PMID 8658138]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 8658138]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 12514101]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 11313481]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 17248528]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 9765213]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02350
similar to AA sequence:KEGG_Orthology:K08739
Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability; GO_component: GO:0032390 - MutLbeta complex [Evidence IEA]; GO_component: GO:0097587 - MutLgamma complex [Evidence IPI] [PMID 9770499]; GO_component: GO:0005712 - chiasma [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10570173]; GO_component: GO:0000795 - synaptonemal complex [Evidence IBA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IBA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 23316435]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IBA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 23316435]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 10679328]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9770499]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10570173]
similar to AA sequence:KEGG_Orthology:K02889
Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15116
Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7891656]; GO_function: GO:0015218 - pyrimidine nucleotide transmembrane transporter activity [Evidence IDA] [PMID 16194150]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 7891656]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 7891656]; GO_process: GO:0006864 - pyrimidine nucleotide transport [Evidence IDA] [PMID 16194150]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 16194150]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03352
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0031497 - chromatin assembly [Evidence IMP] [PMID 12399376]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16481473]
bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2
similar to AA sequence:KEGG_Orthology:K10742
Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 16002643]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 16624861]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16002643]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0071782 - endoplasmic reticulum tubular network [Evidence IDA] [PMID 16469703]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 16624861]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI] [PMID 19665976]; GO_process: GO:0071788 - endoplasmic reticulum tubular network maintenance [Evidence IGI] [PMID 21502358]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI,IMP] [PMID 16469703]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IMP] [PMID 16624861]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI] [PMID 18309084]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI] [PMID 18442980]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI,IPI] [PMID 19665976]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IGI] [PMID 19273614]
Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10397764]; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11302750]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0005543 - phospholipid binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IGI,IPI] [PMID 14704157]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10397764]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8380177]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]
DNA-(apurinic or apyrimidinic site) lyase APN2
similar to AA sequence:KEGG_Orthology:K10772
Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10806210]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 10806210]; GO_function: GO:0008311 - double-stranded DNA 3'-5' exodeoxyribonuclease activity [Evidence IDA] [PMID 11238902]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IDA] [PMID 11238902]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IGI] [PMID 9765213]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17656
Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 15306853]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 23509072]; GO_function: GO:0045182 - translation regulator activity [Evidence IMP] [PMID 19710419]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0097034 - mitochondrial respiratory chain complex IV biogenesis [Evidence IMP] [PMID 15306853]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IGI,IMP,IPI] [PMID 15306853]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IMP] [PMID 19710419]
similar to AA sequence:KEGG_Orthology:K14818
Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9271392]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 9271392]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI,IMP] [PMID 9271392]
similar to AA sequence:KEGG_Orthology:K00793
Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004746 - riboflavin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004746 - riboflavin synthase activity [Evidence IDA,ISS] [PMID 7814407]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 7814407]
acyl-CoA dehydrogenase, mitochondrial precursor
Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11452019]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030684 - preribosome [Evidence IDA] [PMID 17922018]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 11452019]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K01620
Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12676688]; GO_function: GO:0008732 - L-allo-threonine aldolase activity [Evidence IDA] [PMID 9151955]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA,IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004793 - threonine aldolase activity [Evidence IDA] [PMID 9163906]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IDA] [PMID 3086094]; GO_process: GO:0006567 - threonine catabolic process [Evidence IDA] [PMID 3086094]
similar to AA sequence:KEGG_Orthology:K17765
similar to AA sequence:KEGG_Orthology:K13800
Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8391780]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8391780]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IDA,IGI] [PMID 1333436]; GO_function: GO:0004127 - cytidylate kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0019205 - nucleobase-containing compound kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0019201 - nucleotide kinase activity [Evidence IEA]; GO_function: GO:0016776 - phosphotransferase activity, phosphate group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0009041 - uridylate kinase activity [Evidence IDA,IMP] [PMID 1655742]; GO_function: GO:0009041 - uridylate kinase activity [Evidence IDA] [PMID 2549068]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IDA] [PMID 8391780]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IDA] [PMID 2549068]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12848
Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 10449419]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11720284]
calmodulin-dependent protein kinase CMK2
similar to AA sequence:KEGG_Orthology:K08794
similar to AA sequence:KEGG_Orthology:K14808
Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10871363]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IPI] [PMID 16095611]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IGI,IPI] [PMID 16803892]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10077188]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10871363]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10871363]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
proteasome regulatory particle lid subunit RPN9
similar to AA sequence:KEGG_Orthology:K03039
Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 10490597]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 10490597]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10490597]
Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15387819]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IEA]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IDA] [PMID 15387819]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IGI,ISS] [PMID 15387819]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14846
Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11864606]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 11864607]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IPI] [PMID 11864606]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11864607]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 16581791]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06972
Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 15772085]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15606766]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 15606766]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP] [PMID 15772085]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IDA] [PMID 15606766]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IMP] [PMID 15772085]
similar to AA sequence:KEGG_Orthology:K14289
Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17020589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10485850]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10545454]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17020589]; GO_function: GO:0008262 - importin-alpha export receptor activity [Evidence IDA] [PMID 9214382]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12697814]; GO_process: GO:0006611 - protein export from nucleus [Evidence IDA] [PMID 12697814]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 23716718]; GO_process: GO:0006611 - protein export from nucleus [Evidence IDA] [PMID 9853758]; GO_process: GO:0071528 - tRNA re-export from nucleus [Evidence IGI] [PMID 20032305]
similar to AA sequence:KEGG_Orthology:K00327
NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003958 - NADPH-hemoprotein reductase activity [Evidence IEA,IEA]; GO_function: GO:0003958 - NADPH-hemoprotein reductase activity [Evidence IDA] [PMID 9087488]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 11485306]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 9468503]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10838
Protein that recognizes and binds damaged DNA (with Rad23p) during NER; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; NER stands for nucleotide excision repair; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19889839]; GO_component: GO:0000111 - nucleotide-excision repair factor 2 complex [Evidence IDA] [PMID 7768886]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19889839]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9813069]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9837874]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 18936173]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 19889839]
similar to AA sequence:KEGG_Orthology:K05287
ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol (GPI) intermediate; human PIG-Fp is a functional homolog; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence ISS] [PMID 10793139]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 10793139]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 10793139]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 10793139]
similar to AA sequence:KEGG_Orthology:K14401
RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 10523662]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9099738]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 12145212]
Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 15082763]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence ISS] [PMID 15082763]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 18617998]; GO_process: GO:0044419 - interspecies interaction between organisms [Evidence IMP] [PMID 7532890]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
conserved hypothetical protein, similar to Fe II, 2-oxoglutarate-dependent dioxygenases; allele of CaO19.1306
similar to AA sequence:KEGG_Orthology:K15117
Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10428783]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0034658 - isopropylmalate transmembrane transporter activity [Evidence IDA] [PMID 18682385]; GO_function: GO:1901239 - malonate(1-) transmembrane transporter activity [Evidence IDA] [PMID 10428783]; GO_function: GO:0015131 - oxaloacetate transmembrane transporter activity [Evidence IDA] [PMID 10428783]; GO_function: GO:0015116 - sulfate transmembrane transporter activity [Evidence IDA] [PMID 10428783]; GO_process: GO:0034659 - isopropylmalate transport [Evidence IDA] [PMID 18682385]; GO_process: GO:0015729 - oxaloacetate transport [Evidence IDA] [PMID 10428783]; GO_process: GO:0008272 - sulfate transport [Evidence IDA] [PMID 10428783]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
MYND domain-containing protein; required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IMP] [PMID 18070918]; GO_process: GO:0007116 - regulation of cell budding [Evidence IMP,ISS] [PMID 9427754]
similar to AA sequence:KEGG_Orthology:K06912
Mucin family member that functions as an osmosensor in the HOG pathway; functions in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,ISS] [PMID 8550469]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 17627274]; GO_function: GO:0005034 - osmosensor activity [Evidence IGI] [PMID 17627274]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8550469]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 8550469]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 8550469]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 17627274]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IGI,IPI] [PMID 17627274]
putative MAP7 domain-containing protein 3
similar to AA sequence:KEGG_Orthology:K01199
Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 2509432]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IMP] [PMID 7851411]; GO_function: GO:0008061 - chitin binding [Evidence IEA]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence IDA] [PMID 8458852]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16986442]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12350
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA,IMP] [PMID 11566881]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 16862600]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0000298 - endopolyphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0000298 - endopolyphosphatase activity [Evidence IDA,IMP] [PMID 11447286]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IEA]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IMP] [PMID 16862600]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IDA] [PMID 17009950]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006798 - polyphosphate catabolic process [Evidence IDA] [PMID 17009950]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IDA,IMP] [PMID 11447286]
similar to AA sequence:KEGG_Orthology:K00799
ATP-binding cassette alpha-factor transporter STE6
similar to AA sequence:KEGG_Orthology:K05658
Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8045256]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12374868]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 7679674]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7679674]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 11389139]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 8626301]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000770 - peptide pheromone export [Evidence IMP] [PMID 2569166]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K08139
Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IDA] [PMID 16675952]; GO_component: GO:0000113 - nucleotide-excision repair factor 4 complex [Evidence IDA] [PMID 9497356]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 9497356]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9497356]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000715 - nucleotide-excision repair, DNA damage recognition [Evidence IDA,IMP] [PMID 15177043]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16675952]
ATP-binding cassette glutathione S-conjugate transporter YCF1
Vacuolar glutathione S-conjugate transporter; member of ATP-binding cassette family; ATPase activity required to support vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; has role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23658021]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8692889]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015127 - bilirubin transmembrane transporter activity [Evidence IGI,IMP] [PMID 10790694]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 10220408]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12383937]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12755704]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 9217966]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015723 - bilirubin transport [Evidence IGI,IMP] [PMID 10790694]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 10220408]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 12755704]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 9217966]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10790694]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 23658021]
similar to AA sequence:KEGG_Orthology:K04536
G protein beta subunit; forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA] [PMID 8995254]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 11073983]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8995254]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP] [PMID 2107073]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 15192700]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI,IPI] [PMID 10087263]; GO_process: GO:0010525 - regulation of transposition, RNA-mediated [Evidence IMP] [PMID 9566871]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12408816]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19144819]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0017016 - Ras GTPase binding [Evidence ISS] [PMID 17303383]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 19144819]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP,IPI] [PMID 12408816]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 12408816]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence ISS] [PMID 17303383]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]
Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 14697254]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 14697254]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 20182505]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0090156 - cellular sphingolipid homeostasis [Evidence IMP] [PMID 20182505]; GO_process: GO:0090155 - negative regulation of sphingolipid biosynthetic process [Evidence IGI,IMP,IPI] [PMID 20182505]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP,ISS] [PMID 12093374]
similar to AA sequence:KEGG_Orthology:K09140
Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 19806183]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10402465]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10402465]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IDA] [PMID 16390997]; GO_function: GO:0000149 - SNARE binding [Evidence IPI] [PMID 15964280]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IPI] [PMID 10402465]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IPI] [PMID 15964280]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 10402465]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IPI] [PMID 16390997]
similar to AA sequence:KEGG_Orthology:K10777
DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; GO_component: GO:0032807 - DNA ligase IV complex [Evidence IPI] [PMID 17567543]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 10679327]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA] [PMID 9242411]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA,IMP] [PMID 9271115]; GO_function: GO:0003909 - DNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006266 - DNA ligation [Evidence IBA]; GO_process: GO:0051103 - DNA ligation involved in DNA repair [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA] [PMID 15342630]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 9242411]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI] [PMID 18627461]
Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
CORVET complex membrane-binding subunit VPS8
hypothetical protein; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21777356]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21777356]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence ISS] [PMID 10821189]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence ISS] [PMID 10821189]
similar to AA sequence:KEGG_Orthology:K14815
Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19797078]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19797079]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 19797079]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19797079]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0070180 - large ribosomal subunit rRNA binding [Evidence ISA] [PMID 19346338]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 10471698]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI,IMP] [PMID 19797079]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00761
Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 2189783]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0004845 - uracil phosphoribosyltransferase activity [Evidence IEA]; GO_function: GO:0004845 - uracil phosphoribosyltransferase activity [Evidence IDA] [PMID 2189783]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IDA] [PMID 2189783]
hypothetical protein; mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 11816027]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10901
similar to AA sequence:KEGG_Orthology:K00140
similar to AA sequence:KEGG_Orthology:K01652
Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control; GO_component: GO:0005948 - acetolactate synthase complex [Evidence IDA] [PMID 10213630]; GO_component: GO:0005948 - acetolactate synthase complex [Evidence ISS] [PMID 2989783]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IDA] [PMID 10213630]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence ISS] [PMID 2989783]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IDA] [PMID 15709745]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,IMP] [PMID 2406721]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12662
Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA,IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 8202378]
Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; relocalizes to the cytosol in response to hypoxia; similar to Hda2p; GO_component: GO:0070823 - HDA1 complex [Evidence IEA]; GO_component: GO:0070823 - HDA1 complex [Evidence IDA,IPI] [PMID 11287668]; GO_component: GO:0070823 - HDA1 complex [Evidence IDA] [PMID 8663039]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 19573535]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16415367]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IDA] [PMID 19573535]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 16415367]; GO_process: GO:0031047 - gene silencing by RNA [Evidence IMP] [PMID 18022365]; GO_process: GO:0010978 - gene silencing involved in chronological cell aging [Evidence IMP] [PMID 18022365]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA,IMP] [PMID 11287668]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA,IMP] [PMID 8663039]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11287668]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10684
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0031510 - SUMO activating enzyme complex [Evidence IPI] [PMID 9312010]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0019948 - SUMO activating enzyme activity [Evidence IDA] [PMID 9312010]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA] [PMID 9312010]
similar to AA sequence:KEGG_Orthology:K14006
GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 8451644]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0003400 - regulation of COPII vesicle coating [Evidence IDA] [PMID 8451644]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
Arf family guanine nucleotide exchange factor GEA2
similar to AA sequence:KEGG_Orthology:K18443
similar to AA sequence:KEGG_Orthology:K02991
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IBA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 17640275]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22792405]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 17640275]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 17640275]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 17640275]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 17640275]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 17640275]; GO_process: GO:0003400 - regulation of COPII vesicle coating [Evidence IDA,IMP,IPI] [PMID 22792405]
NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17801
Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11381092]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 16601683]; GO_process: GO:0007007 - inner mitochondrial membrane organization [Evidence IDA] [PMID 11381092]; GO_process: GO:0097033 - mitochondrial respiratory chain complex III biogenesis [Evidence IGI,IMP] [PMID 20427570]; GO_process: GO:0097034 - mitochondrial respiratory chain complex IV biogenesis [Evidence IGI,IMP] [PMID 20427570]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IGI] [PMID 20427570]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 16601683]
similar to AA sequence:KEGG_Orthology:K16948
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 3316985]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 18552279]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14993234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9442111]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IMP] [PMID 10882120]; GO_process: GO:0045860 - positive regulation of protein kinase activity [Evidence IDA] [PMID 14527412]; GO_process: GO:0000921 - septin ring assembly [Evidence IDA] [PMID 12636916]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 14993234]
similar to AA sequence:KEGG_Orthology:K12763
Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 8524252]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11046133]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8524252]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein; GO_component: GO:0000417 - HIR complex [Evidence IDA,IPI] [PMID 16264190]; GO_component: GO:0000417 - HIR complex [Evidence IDA] [PMID 16303565]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9001207]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16264190]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16264190]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IMP] [PMID 9001207]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 1406694]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 16449659]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01514
Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7860598]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 12689631]; GO_component: GO:0005759 - mitochondrial matrix [Evidence TAS] [PMID 12689631]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 12689631]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IEA]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IDA] [PMID 17215253]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IDA,IMP] [PMID 7860598]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IEA]; GO_process: GO:0006798 - polyphosphate catabolic process [Evidence IMP] [PMID 7860598]; GO_process: GO:0006798 - polyphosphate catabolic process [Evidence IDA] [PMID 8157625]
similar to AA sequence:KEGG_Orthology:K00003
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004412 - homoserine dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004412 - homoserine dehydrogenase activity [Evidence IDA] [PMID 11341915]; GO_function: GO:0004412 - homoserine dehydrogenase activity [Evidence ISS] [PMID 8500624]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009090 - homoserine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 4380684]
similar to AA sequence:KEGG_Orthology:K11232
Phosphorelay intermediate protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14665464]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14665464]; GO_function: GO:0043424 - protein histidine kinase binding [Evidence IPI] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IDA] [PMID 8808622]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA,IMP] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K07478
Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16251400]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 11459965]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 16251400]; GO_function: GO:0043130 - ubiquitin binding [Evidence ISS] [PMID 17550899]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0033567 - DNA replication, Okazaki fragment processing [Evidence IDA] [PMID 16251400]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 11459965]; GO_process: GO:0006952 - defense response [Evidence IEA]; GO_process: GO:0006282 - regulation of DNA repair [Evidence IGI] [PMID 16809783]
GTPase-activating protein (GAP), subunit of SEA and Iml1p complexes; SEA (Seh1-associated) complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; localized to either pre-autophagosomal structures (PAS) or non-PAS structures during NNS-induced autophagy; GO_component: GO:1990130 - Iml1 complex [Evidence IDA] [PMID 21900499]; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA,IMP,IPI] [PMID 23716719]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:2000785 - regulation of autophagic vacuole assembly [Evidence IMP] [PMID 21900499]; GO_process: GO:0006810 - transport [Evidence IEA]
putative serine/threonine-protein phosphatase
hypothetical protein; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence ISS] [PMID 10618406]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K07739
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,ISS] [PMID 10445034]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IDA] [PMID 7593161]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0070971 - endoplasmic reticulum exit site [Evidence IDA] [PMID 22675024]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 12235121]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 7593161]; GO_process: GO:0048208 - COPII vesicle coating [Evidence IEA]; GO_process: GO:0048208 - COPII vesicle coating [Evidence IDA] [PMID 12235121]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0070973 - protein localization to endoplasmic reticulum exit site [Evidence IMP] [PMID 22675024]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
DNA-directed RNA polymerase core subunit RPC40
similar to AA sequence:KEGG_Orthology:K03027
RNA polymerase subunit AC40; common to RNA polymerase I and III; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
top hit is XP_003029647.1 originated in Schizophyllum commune H4-8
similar to AA sequence:KEGG_Orthology:K03257
Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 2648398]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence IGI] [PMID 10409745]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence IGI,ISS] [PMID 2648398]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA,IMP] [PMID 1502180]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 24471916]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA,IMP] [PMID 1502180]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 2648398]; GO_function: GO:0003743 - translation initiation factor activity [Evidence TAS] [PMID 9841679]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence ISS] [PMID 2648398]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA,IMP] [PMID 1502180]
similar to AA sequence:KEGG_Orthology:K01267
Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 21343297]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005775 - vacuolar lumen [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA] [PMID 16367759]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence ISS] [PMID 15606766]; GO_process: GO:0006508 - proteolysis [Evidence ISS] [PMID 8091229]
similar to AA sequence:KEGG_Orthology:K11238
similar to AA sequence:KEGG_Orthology:K00858
ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003951 - NAD+ kinase activity [Evidence IEA]; GO_function: GO:0003951 - NAD+ kinase activity [Evidence IDA] [PMID 15978040]; GO_function: GO:0042736 - NADH kinase activity [Evidence IEA]; GO_function: GO:0042736 - NADH kinase activity [Evidence IDA] [PMID 15978040]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019674 - NAD metabolic process [Evidence IEA]; GO_process: GO:0006741 - NADP biosynthetic process [Evidence IEA]; GO_process: GO:0006741 - NADP biosynthetic process [Evidence IDA] [PMID 15978040]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16912
Protein required for pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22083961]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23175604]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22083961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8582632]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IPI] [PMID 23175604]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 23175604]; GO_process: GO:0000460 - maturation of 5.8S rRNA [Evidence IMP] [PMID 22083961]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 22083961]
similar to AA sequence:KEGG_Orthology:K00849
Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10866670]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18952899]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18952899]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004335 - galactokinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 8628318]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA]; GO_process: GO:0006012 - galactose metabolic process [Evidence IMP] [PMID 4577139]; GO_process: GO:0045185 - maintenance of protein location [Evidence IMP] [PMID 19651897]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000435 - positive regulation of transcription from RNA polymerase II promoter by galactose [Evidence IMP] [PMID 3013721]
alpha-arrestin involved in ubiquitin-dependent endocytosis; regulates endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; involved in basal internalization and turnover of alpha-factor receptor Ste2p and recovery from pheromone induced G1 arrest; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 22118465]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22118465]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22118465]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence IMP,IPI] [PMID 18976803]
mitochondrial 54S ribosomal protein YmL10/YmL18
similar to AA sequence:KEGG_Orthology:K02876
Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10598
Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR2 has a paralog, CPR5, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 1761234]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12826
similar to AA sequence:KEGG_Orthology:K11380
Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 17157260]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 17157260]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Cell division control protein 45-like protein
transcription factor TFIIIC subunit TFC6
similar to AA sequence:KEGG_Orthology:K15205
similar to AA sequence:KEGG_Orthology:K11996
E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0042292 - URM1 activating enzyme activity [Evidence IDA,ISS] [PMID 10713047]; GO_function: GO:0042292 - URM1 activating enzyme activity [Evidence IMP] [PMID 14555475]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0070733 - protein adenylyltransferase activity [Evidence IMP] [PMID 19145231]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IEA]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IDA] [PMID 18491921]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IMP] [PMID 19145231]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IDA] [PMID 19864628]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0007114 - cell budding [Evidence IGI] [PMID 14551258]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 14555475]; GO_process: GO:0018192 - enzyme active site formation via L-cysteine persulfide [Evidence IEA]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI,IMP] [PMID 14551258]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IDA] [PMID 10713047]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14555475]; GO_process: GO:2000220 - regulation of pseudohyphal growth [Evidence IMP] [PMID 22043304]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18664566]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12825
Subunit of the SF3a splicing factor complex; required for spliceosome assembly; GO_component: GO:0005686 - U2 snRNP [Evidence TAS] [PMID 11804584]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8065365]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 8969185]
similar to AA sequence:KEGG_Orthology:K16365
Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 20850366]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IDA] [PMID 20850366]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 12482202]
similar to AA sequence:KEGG_Orthology:K11450
similar to AA sequence:KEGG_Orthology:K15216
Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19416370]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 23393135]; GO_function: GO:0001042 - RNA polymerase I core binding [Evidence IDA,IPI] [PMID 11032814]; GO_function: GO:0001179 - RNA polymerase I transcription factor binding [Evidence IDA,IPI] [PMID 11032814]; GO_function: GO:0001082 - RNA polymerase I transcription factor binding transcription factor activity [Evidence IDA,IGI,IPI] [PMID 11032814]; GO_function: GO:0001181 - core RNA polymerase I binding transcription factor activity [Evidence IDA,IGI,IPI] [PMID 11032814]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001180 - transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript [Evidence IMP] [PMID 8670901]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15287
similar to AA sequence:KEGG_Orthology:K11826
Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IPI] [PMID 10564262]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 24460703]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IC] [PMID 10564262]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA] [PMID 22650761]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 22650761]
Putative acyltransferase with similarity to Eeb1p and Eht1p; has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence ISS] [PMID 16361250]; GO_process: GO:0051792 - medium-chain fatty acid biosynthetic process [Evidence IGI] [PMID 16361250]
phosphatidylinositol-4-phosphate 5-kinase its3
similar to AA sequence:KEGG_Orthology:K03234
similar to Aspergillus terreus NIH2624 XP_001208692.1
GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0032177 - cellular bud neck split septin rings [Evidence IDA] [PMID 18166650]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 12455995]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 17981141]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 18166650]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IGI,IPI] [PMID 7498791]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 8657111]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IPI] [PMID 10066831]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence IPI] [PMID 10066831]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 18166650]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IPI] [PMID 10066831]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI] [PMID 7498791]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IPI] [PMID 10066831]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IGI] [PMID 14517318]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18914
Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9727014]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015039 - NADPH-adrenodoxin reductase activity [Evidence IDA] [PMID 9727014]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 11035018]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 20534343]
CAF assembly factor (CAF-1) complex large subunit Pcf1
similar to AA sequence:KEGG_Orthology:K11422
DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis; GO_component: GO:0032300 - mismatch repair complex [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15611870]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7961998]; GO_component: GO:0000228 - nuclear chromosome [Evidence IRD]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 7961999]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0032139 - dinucleotide insertion or deletion binding [Evidence IDA] [PMID 7961998]; GO_function: GO:0032137 - guanine/thymine mispair binding [Evidence IDA] [PMID 7961998]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IRD]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 1334021]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IRD]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IRD]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 15611870]; GO_process: GO:0043504 - mitochondrial DNA repair [Evidence IMP] [PMID 1334021]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 1334021]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 1334021]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 15611870]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 15590333]
similar to AA sequence:KEGG_Orthology:K14763
RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12242285]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12515383]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12515383]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 12515383]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP,IPI] [PMID 12228251]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP] [PMID 12242285]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP,IPI] [PMID 12515383]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17815
similar to AA sequence:KEGG_Orthology:K15113
Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1703236]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence IMP] [PMID 12902335]; GO_process: GO:0008380 - RNA splicing [Evidence IGI] [PMID 2448588]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0048250 - mitochondrial iron ion transport [Evidence IDA] [PMID 12902335]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14521
Protein required for biogenesis of the small ribosomal subunit; required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; essential gene; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 12150911]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]
similar to AA sequence:KEGG_Orthology:K01213
Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 10028181]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 11935221]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004650 - polygalacturonase activity [Evidence IEA,IEA]; GO_function: GO:0004650 - polygalacturonase activity [Evidence IDA] [PMID 10650215]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045490 - pectin catabolic process [Evidence IDA] [PMID 10028181]; GO_process: GO:0007124 - pseudohyphal growth [Evidence NAS] [PMID 11255250]
RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19127978]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17030511]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19127978]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA,IMP] [PMID 19127978]; GO_process: GO:0071032 - nuclear mRNA surveillance of mRNP export [Evidence IMP] [PMID 19127978]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IGI,IMP,IPI] [PMID 17030511]
Alpha-arrestin family member; activation through a switch in its modification state relays glucose signaling to transporter endocytosis; contributes to desensitization of agonist-occupied Ste2p by Rsp5p-dependent internalization and to recovery from pheromone induced G1 arrest; interacts with ubiquitin ligase Rsp5p via its 2 PY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8621680]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:0042493 - response to drug [Evidence IMP] [PMID 12163175]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
similar to AA sequence:KEGG_Orthology:K03327
Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015297 - antiporter activity [Evidence ISS] [PMID 12603313]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006556 - S-adenosylmethionine biosynthetic process [Evidence IMP] [PMID 18592490]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 12603313]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13345
C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IEA]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 11370741]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008022 - protein C-terminus binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12667447]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 19687296]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 22471590]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 11370741]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 15536088]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 9090384]; GO_process: GO:0006625 - protein targeting to peroxisome [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence ISS] [PMID 10769178]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 17397106]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IGI,IMP] [PMID 17189486]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00065
similar to AA sequence:KEGG_Orthology:K00008
Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0046526 - D-xylulose reductase activity [Evidence IEA]; GO_function: GO:0046526 - D-xylulose reductase activity [Evidence IDA] [PMID 10486580]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0042732 - D-xylose metabolic process [Evidence IEA]; GO_process: GO:0019569 - L-arabinose catabolic process to xylulose 5-phosphate [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0005999 - xylulose biosynthetic process [Evidence IDA,IEP] [PMID 10486580]
similar to AA sequence:KEGG_Orthology:K06944
similar to AA sequence:KEGG_Orthology:K03243
Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 9624054]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 21335519]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP,ISS] [PMID 12471154]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,IMP] [PMID 19029250]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10982835]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 21335519]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9624054]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA] [PMID 10982835]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IMP] [PMID 17242201]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 22751017]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 12507428]; GO_process: GO:0042255 - ribosome assembly [Evidence IMP] [PMID 22770215]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
isopentenyl-diphosphate delta-isomerase IDI1
similar to AA sequence:KEGG_Orthology:K01823
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004452 - isopentenyl-diphosphate delta-isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004452 - isopentenyl-diphosphate delta-isomerase activity [Evidence IDA] [PMID 2681212]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0050992 - dimethylallyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IDA] [PMID 7858969]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10610
similar to AA sequence:KEGG_Orthology:K02325
Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15282802]; GO_component: GO:0008622 - epsilon DNA polymerase complex [Evidence IDA] [PMID 12571237]; GO_component: GO:0008622 - epsilon DNA polymerase complex [Evidence IDA] [PMID 14673157]; GO_component: GO:0008622 - epsilon DNA polymerase complex [Evidence IDA] [PMID 2406268]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 12882968]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 16369485]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 14622139]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 16916794]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 14622139]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IDA] [PMID 12882968]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IDA] [PMID 14622139]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IDA] [PMID 16369485]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA,IMP] [PMID 19776424]; GO_process: GO:0070868 - heterochromatin organization involved in chromatin silencing [Evidence IC] [PMID 14673157]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IMP] [PMID 18245343]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IMP] [PMID 19463834]
similar to AA sequence:KEGG_Orthology:K05956
Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8183917]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IPI] [PMID 8232542]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8583924]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8756702]; GO_function: GO:0004663 - Rab geranylgeranyltransferase activity [Evidence IEA]; GO_function: GO:0004663 - Rab geranylgeranyltransferase activity [Evidence IDA] [PMID 8756702]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 3312234]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8232541]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IDA] [PMID 8756702]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 1903184]
similar to AA sequence:KEGG_Orthology:K11650
73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 8804308]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8816487]; GO_process: GO:0061412 - positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [Evidence IMP] [PMID 10549298]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02209
Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IPI] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 2279699]; GO_component: GO:0000784 - nuclear chromosome, telomeric region [Evidence IDA] [PMID 19005221]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 2279699]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10075735]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 2279699]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 16980387]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0006343 - establishment of chromatin silencing [Evidence IMP] [PMID 12750362]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19005221]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 2044962]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 9990508]
similar to AA sequence:KEGG_Orthology:K14675
Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16267052]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0071618 - lysophosphatidylethanolamine acyltransferase activity [Evidence IDA] [PMID 20016004]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 12682047]; GO_process: GO:0007114 - cell budding [Evidence IGI,IMP] [PMID 19150427]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10515935]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI,IMP] [PMID 16267052]
similar to AA sequence:KEGG_Orthology:K11377
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 22343726]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 22343726]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09522
Ribosome-associated chaperone; functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20368619]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IMP] [PMID 20368619]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 16413483]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 17242366]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence NAS] [PMID 9707440]; GO_process: GO:0006457 - protein folding [Evidence NAS] [PMID 9707440]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20368619]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 15456889]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 20368619]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 16607023]
similar to AA sequence:KEGG_Orthology:K14642
Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10551827]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 10409709]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0017110 - nucleoside-diphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 10409709]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9115231]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14988731]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 14988731]; GO_process: GO:0030001 - metal ion transport [Evidence IMP] [PMID 9115231]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 14988731]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 9988727]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16456538]
similar to AA sequence:KEGG_Orthology:K00463
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0033754 - indoleamine 2,3-dioxygenase activity [Evidence IEA]; GO_function: GO:0033754 - indoleamine 2,3-dioxygenase activity [Evidence IDA] [PMID 21170645]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0019441 - tryptophan catabolic process to kynurenine [Evidence IC] [PMID 21170645]
similar to AA sequence:KEGG_Orthology:K10563
malate dehydrogenase (oxaloacetate-decarboxylating)
similar to AA sequence:KEGG_Orthology:K00027
Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9603875]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0004471 - malate dehydrogenase (decarboxylating) (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IDA,ISS] [PMID 9603875]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008948 - oxaloacetate decarboxylase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IMP] [PMID 9603875]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 9603875]
Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03122
TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005672 - transcription factor TFIIA complex [Evidence IEA]; GO_component: GO:0005672 - transcription factor TFIIA complex [Evidence IDA] [PMID 7862117]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 7604282]; GO_function: GO:0001129 - TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [Evidence IDA,IGI] [PMID 10567590]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA,IGI] [PMID 10567590]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 7862117]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07243
High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress; GO_component: GO:0033573 - high affinity iron permease complex [Evidence IDA] [PMID 16522632]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10748025]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16700543]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence IDA] [PMID 16700543]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence IDA] [PMID 8599111]; GO_process: GO:1901684 - arsenate ion transmembrane transport [Evidence IGI] [PMID 23295455]; GO_process: GO:0006827 - high-affinity iron ion transport [Evidence IMP] [PMID 16700543]; GO_process: GO:0006827 - high-affinity iron ion transport [Evidence IGI,IMP] [PMID 8599111]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0033215 - iron assimilation by reduction and transport [Evidence IMP] [PMID 16700543]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15156
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IPI] [PMID 11470794]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14404
Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9224719]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 10899131]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,TAS] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 10899131]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA,TAS] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 9171383]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 19380492]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0051457 - maintenance of protein location in nucleus [Evidence IPI] [PMID 19380492]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI] [PMID 9106207]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI,IMP] [PMID 9171427]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20065092]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20065092]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000301 - retrograde transport, vesicle recycling within Golgi [Evidence IMP] [PMID 11703943]; GO_process: GO:0006810 - transport [Evidence IEA]
phosphoribosylglycinamide formyltransferase
similar to AA sequence:KEGG_Orthology:K00601
Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016742 - hydroxymethyl-, formyl- and related transferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004644 - phosphoribosylglycinamide formyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004644 - phosphoribosylglycinamide formyltransferase activity [Evidence IGI,IMP] [PMID 4581491]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 4581491]; GO_process: GO:0046084 - adenine biosynthetic process [Evidence IMP] [PMID 17247984]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 4581491]
similar to AA sequence:KEGG_Orthology:K02739
Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18504300]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9207060]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9312134]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11373
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD); GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 24750273]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14571
Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11447111]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11447111]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 18559667]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 11447111]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI,IMP] [PMID 18559667]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11447111]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12195
Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12194857]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 15086794]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IGI] [PMID 23444383]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12953057]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
similar to AA sequence:KEGG_Orthology:K01698
Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IEA,IEA]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IDA] [PMID 2204246]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IMP] [PMID 2445751]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IMP] [PMID 323256]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 323256]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
succinate--CoA ligase (GDP-forming) subunit beta
similar to AA sequence:KEGG_Orthology:K01900
Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IDA,IMP,ISS] [PMID 9874242]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence IDA] [PMID 9874242]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
similar to AA sequence:KEGG_Orthology:K06947
Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated; GO_component: GO:0030874 - nucleolar chromatin [Evidence IPI] [PMID 20814424]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051731 - polynucleotide 5'-hydroxyl-kinase activity [Evidence IDA] [PMID 20814424]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 23175604]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0006363 - termination of RNA polymerase I transcription [Evidence IMP] [PMID 20814424]
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12024012]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11399075]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 12024012]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9755175]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IPI] [PMID 11399075]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IPI] [PMID 11399075]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IPI] [PMID 9755175]; GO_process: GO:0016458 - gene silencing [Evidence IMP] [PMID 15016375]; GO_process: GO:1900460 - negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15466424]; GO_process: GO:1900460 - negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 9811878]; GO_process: GO:1900462 - negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12024012]; GO_process: GO:1900462 - negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 9811878]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17594096]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00101
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 3004948]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 3004948]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
succinate--CoA ligase (GDP-forming) subunit alpha
similar to AA sequence:KEGG_Orthology:K01899
Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003878 - ATP citrate synthase activity [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IDA,IMP,ISS] [PMID 9874242]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence IDA] [PMID 9874242]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
transcription factor TFIIIB subunit BRF1
similar to AA sequence:KEGG_Orthology:K15196
similar to AA sequence:KEGG_Orthology:K13525
AAA ATPase; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing, in macroautophagy, PMN, RAD, ribophagy, homotypic ER membrane fusion, disassembly of Met30p from SCF complex, functional ortholog of human p97/VCP; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0036266 - Cdc48p-Npl4p-Vms1p AAA ATPase complex [Evidence IDA] [PMID 21070972]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15910746]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 15910746]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 21070972]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9436996]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 7492595]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008599 - protein phosphatase type 1 regulator activity [Evidence IMP] [PMID 23418575]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 11733065]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11756557]; GO_process: GO:1990171 - SCF complex disassembly in response to cadmium stress [Evidence IMP] [PMID 23000173]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0016320 - endoplasmic reticulum membrane fusion [Evidence IMP] [PMID 7553849]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20855502]; GO_process: GO:0072671 - mitochondria-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21070972]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 14636562]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22718752]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 20855502]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:0034517 - ribophagy [Evidence IMP] [PMID 20508643]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23479637]; GO_process: GO:0031134 - sister chromatid biorientation [Evidence IMP] [PMID 20483956]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12827
Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8065365]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 8969185]
similar to AA sequence:KEGG_Orthology:K03138
TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 12242279]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 7995524]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IDA] [PMID 14749386]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IC] [PMID 7995524]; GO_function: GO:0072542 - protein phosphatase activator activity [Evidence IDA] [PMID 11904169]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 7995524]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IGI] [PMID 11003641]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11904169]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0080163 - regulation of protein serine/threonine phosphatase activity [Evidence IDA] [PMID 11904169]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 18362165]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 18362165]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI,IMP] [PMID 15572698]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI,IMP] [PMID 16081422]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI] [PMID 16147988]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 18362165]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI] [PMID 7724527]
similar to AA sequence:KEGG_Orthology:K00670
Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; GO_component: GO:0031415 - NatA complex [Evidence IDA] [PMID 14517307]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 14517307]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IDA,IMP] [PMID 2551674]; GO_process: GO:0006474 - N-terminal protein amino acid acetylation [Evidence IDA,IMP] [PMID 2551674]
bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2
similar to AA sequence:KEGG_Orthology:K14655
Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence ISM] [PMID 15466869]; GO_function: GO:0043723 - 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity [Evidence IMP] [PMID 4555411]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008835 - diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 15466869]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence ISS] [PMID 8710514]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 4555411]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15466869]
Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISM] [PMID 15466869]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 15466869]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15466869]
similar to AA sequence:KEGG_Orthology:K14856
Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704371]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 10704371]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 15107621]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 15107621]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007089 - traversing start control point of mitotic cell cycle [Evidence IMP] [PMID 11160833]
similar to AA sequence:KEGG_Orthology:K14778
ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11222764]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 11222764]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 16772403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11222764]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11222764]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11222764]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11600
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IGI,IMP] [PMID 11030620]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18591258]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
hypothetical protein; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 10093218]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15114
Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 8798783]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0000064 - L-ornithine transmembrane transporter activity [Evidence IDA] [PMID 9237680]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 8798783]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000066 - mitochondrial ornithine transport [Evidence IDA] [PMID 9237680]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14026
ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IPI] [PMID 16619026]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0034099 - luminal surveillance complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11390656]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 12105183]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 24292014]
Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008251 - tRNA-specific adenosine deaminase activity [Evidence IDA] [PMID 10550050]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 10550050]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17919
Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12048214]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 17420293]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 12048214]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 12048214]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 12554655]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12048214]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12554655]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI,IMP,IPI] [PMID 12554655]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12554655]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10761
tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008193 - tRNA guanylyltransferase activity [Evidence IEA]; GO_function: GO:0008193 - tRNA guanylyltransferase activity [Evidence IDA] [PMID 14633974]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 14633974]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
proteasome regulatory particle lid subunit RPN3
similar to AA sequence:KEGG_Orthology:K03033
Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control; GO_component: GO:0000502 - proteasome complex [Evidence IEA,IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0042176 - regulation of protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
similar to AA sequence:KEGG_Orthology:K11446
JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates spore differentiation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0032453 - histone demethylase activity (H3-K4 specific) [Evidence IDA,IMP] [PMID 17310254]; GO_function: GO:0032453 - histone demethylase activity (H3-K4 specific) [Evidence IMP] [PMID 17369256]; GO_function: GO:0034649 - histone demethylase activity (H3-monomethyl-K4 specific) [Evidence IMP] [PMID 19346402]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0034720 - histone H3-K4 demethylation [Evidence IMP] [PMID 23123093]; GO_process: GO:0016577 - histone demethylation [Evidence IDA,IMP] [PMID 17310254]; GO_process: GO:0016577 - histone demethylation [Evidence IMP] [PMID 17369256]; GO_process: GO:0097549 - negative regulation of transcription by chromatin organization [Evidence IMP] [PMID 23123093]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
methylenetetrahydrofolate reductase (NAD(P)H) MET12
similar to AA sequence:KEGG_Orthology:K00297
Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR); GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IEA,IEA]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IDA,ISS] [PMID 10600168]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006555 - methionine metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
hypothetical protein; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K01181
similar to AA sequence:KEGG_Orthology:K09490
ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 2661018]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0034099 - luminal surveillance complex [Evidence IDA] [PMID 16873065]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 1325440]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 12808051]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 23704572]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 7568189]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 10069807]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 10367885]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 7568189]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP] [PMID 12808051]
similar to AA sequence:KEGG_Orthology:K02537
Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 12473689]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IPI] [PMID 10704439]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IDA,IPI] [PMID 11726501]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 12473689]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051312 - chromosome decondensation [Evidence IMP] [PMID 17151360]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP] [PMID 10704439]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IPI] [PMID 9461437]
similar to AA sequence:KEGG_Orthology:K03262
Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IPI] [PMID 9671501]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0005092 - GDP-dissociation inhibitor activity [Evidence IDA,IMP] [PMID 20485439]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence ISS] [PMID 11092890]; GO_function: GO:0005096 - GTPase activator activity [Evidence IPI] [PMID 9395514]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 22683627]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9395514]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 8486705]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 9395514]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA] [PMID 22683627]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 22851688]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0042256 - mature ribosome assembly [Evidence IMP] [PMID 11331597]; GO_process: GO:0045947 - negative regulation of translational initiation [Evidence IGI,IMP] [PMID 20485439]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP,IPI] [PMID 11331597]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA,IMP] [PMID 22851688]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
DNA-binding E3 ubiquitin-protein ligase SNT2
similar to AA sequence:KEGG_Orthology:K11092
Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein; GO_component: GO:0005686 - U2 snRNP [Evidence IDA,IPI] [PMID 9799242]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 9799242]
bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase
similar to AA sequence:KEGG_Orthology:K14154
Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16850348]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004417 - hydroxyethylthiazole kinase activity [Evidence IEA,IEA]; GO_function: GO:0004417 - hydroxyethylthiazole kinase activity [Evidence IMP] [PMID 7982968]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004789 - thiamine-phosphate diphosphorylase activity [Evidence IEA,IEA]; GO_function: GO:0004789 - thiamine-phosphate diphosphorylase activity [Evidence IMP] [PMID 7982968]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IMP] [PMID 7982968]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence IEA]
Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14657274]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence ISS] [PMID 14534547]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IDA] [PMID 18946088]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP,ISS] [PMID 14657274]; GO_process: GO:0006915 - apoptotic process [Evidence IMP,ISS] [PMID 16470384]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16608876]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP,IPI] [PMID 16470384]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 18946088]; GO_process: GO:0030163 - protein catabolic process [Evidence IMP] [PMID 18946088]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
Chromosome transmission fidelity protein 8
similar to AA sequence:KEGG_Orthology:K11270
Covalently-bound cell wall hypothetical protein; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11935221]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K01610
Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 196563]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004612 - phosphoenolpyruvate carboxykinase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0004612 - phosphoenolpyruvate carboxykinase (ATP) activity [Evidence IDA] [PMID 16330239]; GO_function: GO:0004612 - phosphoenolpyruvate carboxykinase (ATP) activity [Evidence IMP] [PMID 2689220]; GO_function: GO:0004611 - phosphoenolpyruvate carboxykinase activity [Evidence IEA]; GO_function: GO:0017076 - purine nucleotide binding [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 2689220]
Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 16034825]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13754
similar to AA sequence:KEGG_Orthology:K13217
U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9418882]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 9418882]
similar to AA sequence:KEGG_Orthology:K01749
Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004418 - hydroxymethylbilane synthase activity [Evidence IEA,IEA]; GO_function: GO:0004418 - hydroxymethylbilane synthase activity [Evidence IMP] [PMID 1508149]; GO_function: GO:0004418 - hydroxymethylbilane synthase activity [Evidence IMP] [PMID 323256]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 323256]; GO_process: GO:0018160 - peptidyl-pyrromethane cofactor linkage [Evidence IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
putative isochorismatase family protein yrdC
similar to AA sequence:KEGG_Orthology:K06630
14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; BMH2 has a paralog, BMH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12167636]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 12167636]; GO_function: GO:0050815 - phosphoserine binding [Evidence IMP] [PMID 9822578]; GO_function: GO:0019904 - protein domain specific binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 14704161]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI] [PMID 19934224]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI] [PMID 9215628]; GO_process: GO:0030437 - ascospore formation [Evidence IGI] [PMID 9215628]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI] [PMID 17559233]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IGI] [PMID 9215628]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IMP] [PMID 22785534]; GO_process: GO:0051436 - negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [Evidence IPI] [PMID 17030612]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IGI] [PMID 19934224]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 9215628]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IGI] [PMID 9215628]
similar to AA sequence:KEGG_Orthology:K00286
Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7009582]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004735 - pyrroline-5-carboxylate reductase activity [Evidence IEA,IEA]; GO_function: GO:0004735 - pyrroline-5-carboxylate reductase activity [Evidence ISS] [PMID 1508147]; GO_function: GO:0004735 - pyrroline-5-carboxylate reductase activity [Evidence IGI] [PMID 2824433]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IMP,ISS] [PMID 1508147]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IMP] [PMID 2824433]
similar to AA sequence:KEGG_Orthology:K13342
Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins; required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8858166]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 16849337]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IPI] [PMID 8858166]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15632140]; GO_function: GO:0005052 - peroxisome matrix targeting signal-1 binding [Evidence IMP] [PMID 11154700]; GO_function: GO:0005052 - peroxisome matrix targeting signal-1 binding [Evidence IDA] [PMID 7980572]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 15798189]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 12595255]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IMP,IPI] [PMID 16849337]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15134
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0033613 - activating transcription factor binding [Evidence IDA] [PMID 9660972]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IMP] [PMID 19805365]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IPI] [PMID 21415355]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 16962561]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8187178]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 16263706]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2; GO_component: GO:0000974 - Prp19 complex [Evidence IPI] [PMID 12088152]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 19435883]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 19435883]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IDA] [PMID 19435883]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 19435883]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0036002 - pre-mRNA binding [Evidence IDA] [PMID 19435883]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 19435883]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0045292 - mRNA cis splicing, via spliceosome [Evidence IMP] [PMID 19435883]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12088152]; GO_process: GO:0000387 - spliceosomal snRNP assembly [Evidence IDA] [PMID 19435883]
Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 20739461]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 20739461]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 20956561]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:2000397 - positive regulation of ubiquitin-dependent endocytosis [Evidence IMP] [PMID 20956561]; GO_process: GO:0032386 - regulation of intracellular transport [Evidence IMP] [PMID 20739461]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
ribosome biogenesis protein Rix1 (predicted)
similar to AA sequence:KEGG_Orthology:K01466
Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004038 - allantoinase activity [Evidence IEA,IEA]; GO_function: GO:0004038 - allantoinase activity [Evidence IMP] [PMID 1803816]; GO_function: GO:0004038 - allantoinase activity [Evidence IMP] [PMID 4604238]; GO_function: GO:0050897 - cobalt ion binding [Evidence IEA]; GO_function: GO:0016888 - endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0009442 - allantoin assimilation pathway [Evidence IMP] [PMID 1803816]; GO_process: GO:0009442 - allantoin assimilation pathway [Evidence IMP] [PMID 4604238]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IEA,IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02127
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0000276 - mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IBA,IEA]; GO_component: GO:0000274 - mitochondrial proton-transporting ATP synthase, stator stalk [Evidence IDA] [PMID 18722382]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045263 - proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 8068646]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 8068646]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0035786 - protein complex oligomerization [Evidence IMP] [PMID 18293929]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 18806213]; GO_process: GO:0009967 - positive regulation of signal transduction [Evidence IMP] [PMID 18806213]
similar to AA sequence:KEGG_Orthology:K12812
Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IPI] [PMID 15942929]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence TAS] [PMID 9476892]; GO_component: GO:0000346 - transcription export complex [Evidence IPI] [PMID 11979277]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IGI,ISA] [PMID 11156602]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 15942929]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IDA,IMP,IPI] [PMID 11675790]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IDA,IMP] [PMID 11696331]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11156602]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 17960421]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03134
Subunit (145 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 11940675]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8662725]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00383
Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 23613772]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23613772]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004362 - glutathione-disulfide reductase activity [Evidence IEA,IEA]; GO_function: GO:0004362 - glutathione-disulfide reductase activity [Evidence IDA] [PMID 19049979]; GO_function: GO:0004362 - glutathione-disulfide reductase activity [Evidence IDA] [PMID 7737505]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016668 - oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 8951820]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0010731 - protein glutathionylation [Evidence IGI] [PMID 20074363]
similar to AA sequence:KEGG_Orthology:K11093
Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0030619 - U1 snRNA binding [Evidence IPI] [PMID 1387202]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]
similar to AA sequence:KEGG_Orthology:K01078
similar to AA sequence:KEGG_Orthology:K07112
bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
similar to AA sequence:KEGG_Orthology:K14729
3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence ISM] [PMID 1551874]; GO_function: GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004300 - enoyl-CoA hydratase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 10497229]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 1551874]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01637
2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 11092862]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046421 - methylisocitrate lyase activity [Evidence IEA]; GO_function: GO:0046421 - methylisocitrate lyase activity [Evidence IDA] [PMID 11092862]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019629 - propionate catabolic process, 2-methylcitrate cycle [Evidence IDA] [PMID 11092862]
Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14998
Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15306853]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15306853]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9162072]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 11389896]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9162072]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP,IPI] [PMID 17882259]
similar to AA sequence:KEGG_Orthology:K00900
6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1657152]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IEA,IEA]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IDA] [PMID 1322693]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IMP] [PMID 1657152]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IMP] [PMID 1657152]; GO_process: GO:0006000 - fructose metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K06176
Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 12682021]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IMP] [PMID 18332121]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000455 - enzyme-directed rRNA pseudouridine synthesis [Evidence IMP] [PMID 18332121]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 12682021]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IMP] [PMID 14561887]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IMP] [PMID 14561887]
similar to AA sequence:KEGG_Orthology:K15275
Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005459 - UDP-galactose transmembrane transporter activity [Evidence ISS] [PMID 11284010]; GO_process: GO:0015785 - UDP-galactose transport [Evidence IMP] [PMID 11284009]; GO_process: GO:0015786 - UDP-glucose transport [Evidence IGI,IMP] [PMID 18693752]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02734
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 15973433]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10419517]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0061133 - endopeptidase activator activity [Evidence IMP] [PMID 8808631]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12818
similar to AA sequence:KEGG_Orthology:K01803
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IDA] [PMID 236471]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 11329176]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02307
Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments; GO_component: GO:0042729 - DASH complex [Evidence IEA]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15640796]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15664196]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0072686 - mitotic spindle [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 15664196]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 16777964]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 17620411]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 20479465]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IEA]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 17620411]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479465]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479468]; GO_process: GO:0031116 - positive regulation of microtubule polymerization [Evidence IDA] [PMID 15664196]
similar to AA sequence:KEGG_Orthology:K18803
AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 12872006]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0018064 - protein-histidine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0018064 - protein-histidine N-methyltransferase activity [Evidence IMP] [PMID 20864530]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0042038 - peptidyl-histidine methylation, to form tele-methylhistidine [Evidence IMP] [PMID 20864530]
Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11536335]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0015293 - symporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11536335]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 11536335]
similar to AA sequence:KEGG_Orthology:K05758
Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 9210376]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IPI] [PMID 14554195]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 10377407]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 14554195]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 14554195]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 11248049]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 7929582]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
putative mitochondrial 37S ribosomal protein MRPS12
similar to AA sequence:KEGG_Orthology:K02950
Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence ISA] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence ISA] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence ISA] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
putative serine/threonine-protein kinase PPG1
similar to AA sequence:KEGG_Orthology:K17615
Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence ISS] [PMID 7678255]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IMP] [PMID 7678255]; GO_process: GO:0006470 - protein dephosphorylation [Evidence ISS] [PMID 7678255]
one of three or four genes related to conserved fungal hypothetical proteins (NCU00659.1, MG03673.4, AN4711.2)
aminophospholipid-translocating P4-type ATPase DNF2
Aminophospholipid translocase (flippase); localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; DNF2 has a paralog, DNF1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12221123]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12631737]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 12631737]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 12631737]; GO_process: GO:0007163 - establishment or maintenance of cell polarity [Evidence IGI] [PMID 15461661]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI,IMP] [PMID 12631737]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
aminophospholipid-translocating P4-type ATPase DNF1
similar to AA sequence:KEGG_Orthology:K01530
Aminophospholipid translocase (flippase); localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; DNF1 has a paralog, DNF2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12221123]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12631737]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence ISS] [PMID 9224683]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 12631737]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 12631737]; GO_process: GO:0007163 - establishment or maintenance of cell polarity [Evidence IGI] [PMID 15461661]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI] [PMID 12631737]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
bifunctional choline kinase/ethanolamine kinase EKI1
similar to AA sequence:KEGG_Orthology:K00894
Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004103 - choline kinase activity [Evidence IDA,IGI,ISS] [PMID 10329685]; GO_function: GO:0004305 - ethanolamine kinase activity [Evidence IEA]; GO_function: GO:0004305 - ethanolamine kinase activity [Evidence IDA,IGI,IMP,ISS] [PMID 10329685]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09506
Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20368619]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17242366]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 17242366]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IMP] [PMID 20368619]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 17242366]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20368619]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17242366]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 20368619]
similar to AA sequence:KEGG_Orthology:K00791
Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9872948]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9872948]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9872948]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9872948]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0052381 - tRNA dimethylallyltransferase activity [Evidence IEA]; GO_function: GO:0052381 - tRNA dimethylallyltransferase activity [Evidence IDA] [PMID 18852462]; GO_function: GO:0052381 - tRNA dimethylallyltransferase activity [Evidence IDA] [PMID 3031456]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 18852462]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 3031456]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12200
Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 11698381]; GO_process: GO:0016485 - protein processing [Evidence IDA,IGI,IMP] [PMID 11698381]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 11698381]; GO_process: GO:0009268 - response to pH [Evidence IMP] [PMID 11698381]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 11698381]
similar to AA sequence:KEGG_Orthology:K12391
Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI,ISS] [PMID 10564262]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IPI,ISS] [PMID 10564262]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 17003107]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IPI,ISS] [PMID 10564262]
similar to AA sequence:KEGG_Orthology:K14007
Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IMP] [PMID 12941277]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 12941277]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 14627716]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 15665868]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00566
tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF); GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15944150]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IEA]; GO_function: GO:0004808 - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004808 - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity [Evidence IMP] [PMID 15509579]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0070903 - mitochondrial tRNA thio-modification [Evidence IMP] [PMID 15509579]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
NADH-ubiquinone reductase (H(+)-translocating) NDE1
similar to AA sequence:KEGG_Orthology:K17871
Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9696750]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9733747]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9696750]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9733747]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 16436509]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9696750]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9733747]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14293
Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0005087 - Ran guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 19549784]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 7622450]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IMP] [PMID 17182855]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IGI,IMP] [PMID 19141610]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 19141610]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 23131016]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 16929305]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0060188 - regulation of protein desumoylation [Evidence IMP] [PMID 17403926]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15340
Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1736091]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0008409 - 5'-3' exonuclease activity [Evidence IDA,IMP] [PMID 15590324]; GO_function: GO:0003684 - damaged DNA binding [Evidence IMP] [PMID 7035927]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 1736091]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence TAS] [PMID 12509272]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI,IMP] [PMID 22912599]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08192
Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16874307]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 16874307]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 8756348]; GO_process: GO:0009968 - negative regulation of signal transduction [Evidence IEA]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IGI,IMP] [PMID 19684113]; GO_process: GO:0009966 - regulation of signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01408
Metalloprotease; involved in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family; homolog Axl1p is also involved in processing of pro-a-factor; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 15944156]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 19750477]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence ISS] [PMID 7569998]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IGI] [PMID 7569998]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]
NEDD4 family E3 ubiquitin-protein ligase
similar to AA sequence:KEGG_Orthology:K10591
E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; deubiquitinated by Ubp2p; autoubiquitinates and ubiquitinates Sec23p and Sna3p; required for efficient Golgi-to-ER trafficking in COPI mutants; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14657247]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 14608372]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14657247]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15078904]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 14657247]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 15078904]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14608372]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IPI] [PMID 9931424]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IDA] [PMID 15078904]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 19252184]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 21685393]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 9108033]; GO_process: GO:0034644 - cellular response to UV [Evidence IMP] [PMID 10490634]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IMP] [PMID 12399376]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP,IPI] [PMID 17182849]; GO_process: GO:0007005 - mitochondrion organization [Evidence IGI,IMP] [PMID 10366593]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 12654912]; GO_process: GO:0045723 - positive regulation of fatty acid biosynthetic process [Evidence IMP] [PMID 11007476]; GO_process: GO:0048260 - positive regulation of receptor-mediated endocytosis [Evidence IMP] [PMID 11179425]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11007476]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 15713680]; GO_process: GO:0051865 - protein autoubiquitination [Evidence IGI] [PMID 24069405]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IGI,IMP] [PMID 14761940]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IGI,IMP] [PMID 19176477]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IMP] [PMID 21685393]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA,IMP] [PMID 9108033]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9614172]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IGI] [PMID 15855235]; GO_process: GO:0010794 - regulation of dolichol biosynthetic process [Evidence IGI,IMP] [PMID 18771750]; GO_process: GO:0032443 - regulation of ergosterol biosynthetic process [Evidence IGI,IMP] [PMID 18771750]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 21685393]; GO_process: GO:0010793 - regulation of mRNA export from nucleus [Evidence IMP] [PMID 14608372]; GO_process: GO:0010793 - regulation of mRNA export from nucleus [Evidence IPI] [PMID 15713680]; GO_process: GO:0010796 - regulation of multivesicular body size [Evidence IMP] [PMID 17182850]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IGI] [PMID 15247235]; GO_process: GO:0019220 - regulation of phosphate metabolic process [Evidence IGI] [PMID 18165238]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP,IPI] [PMID 12867034]; GO_process: GO:2000232 - regulation of rRNA processing [Evidence IMP] [PMID 14608372]; GO_process: GO:2000203 - regulation of ribosomal large subunit export from nucleus [Evidence IMP] [PMID 14608372]; GO_process: GO:2000238 - regulation of tRNA export from nucleus [Evidence IMP] [PMID 14608372]; GO_process: GO:2000235 - regulation of tRNA processing [Evidence IMP] [PMID 14608372]; GO_process: GO:0010795 - regulation of ubiquinone biosynthetic process [Evidence IGI,IMP] [PMID 18771750]; GO_process: GO:0042493 - response to drug [Evidence IMP,IPI] [PMID 12163175]; GO_process: GO:0034517 - ribophagy [Evidence IGI] [PMID 18670191]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence IMP] [PMID 17344478]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 17344478]
Permease of basic amino acids in the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15572352]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015174 - basic amino acid transmembrane transporter activity [Evidence IDA,IMP] [PMID 15572352]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015802 - basic amino acid transport [Evidence IMP] [PMID 15572352]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02684
Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:1990077 - primosome complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 2644256]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3061469]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3888995]; GO_function: GO:0003896 - DNA primase activity [Evidence IGI,IMP] [PMID 8436268]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 20404922]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 2023935]; GO_process: GO:0006270 - DNA replication initiation [Evidence IC] [PMID 3888995]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IEA,IEA]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IDA] [PMID 2644256]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]
similar to AA sequence:KEGG_Orthology:K06686
Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12937277]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12937277]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 8131744]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 17005296]; GO_process: GO:0010458 - exit from mitosis [Evidence IGI,ISS] [PMID 1916278]; GO_process: GO:0000281 - mitotic cytokinesis [Evidence IGI] [PMID 12937277]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8131744]; GO_process: GO:0061013 - regulation of mRNA catabolic process [Evidence IMP] [PMID 22196726]
RanGTP-binding protein; inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12578832]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP,ISS] [PMID 12578832]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0030695 - GTPase regulator activity [Evidence IDA,IPI] [PMID 12578832]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11504737]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 21586585]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 11504737]; GO_process: GO:0036003 - positive regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 16176797]; GO_process: GO:0036003 - positive regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 16980434]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16176797]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16980434]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05767
GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0031235 - intrinsic component of the cytoplasmic side of the plasma membrane [Evidence IBA]; GO_component: GO:0016020 - membrane [Evidence IMP,IPI] [PMID 1875942]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA,IEA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IMP] [PMID 2178777]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence IMP] [PMID 15339905]; GO_process: GO:0030818 - negative regulation of cAMP biosynthetic process [Evidence IMP] [PMID 2540426]; GO_process: GO:0032320 - positive regulation of Ras GTPase activity [Evidence IMP] [PMID 2178777]; GO_process: GO:0045761 - regulation of adenylate cyclase activity [Evidence IMP] [PMID 1875942]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
nicotinate-nucleotide diphosphorylase (carboxylating)
similar to AA sequence:KEGG_Orthology:K00767
Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004514 - nicotinate-nucleotide diphosphorylase (carboxylating) activity [Evidence IEA,IEA]; GO_function: GO:0004514 - nicotinate-nucleotide diphosphorylase (carboxylating) activity [Evidence IMP] [PMID 12062417]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA,IEA]
transcription factor TFIIIC subunit TFC1
similar to AA sequence:KEGG_Orthology:K15202
similar to AA sequence:KEGG_Orthology:K14012
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IMP] [PMID 17173333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence ISS] [PMID 9341119]; GO_process: GO:0009436 - glyoxylate catabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence ISS] [PMID 9341119]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14009
hypothetical protein; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 20378542]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05544
Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence ISS] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence ISS] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
mitochondrial 37S ribosomal protein RSM18
some similarities with uniprot|P40033 Saccharomyces cerevisiae YER050C
similar to AA sequence:KEGG_Orthology:K14575
ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 12006565]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA,IMP] [PMID 17646390]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12006565]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence IMP] [PMID 9341149]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17646390]
Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006529 - asparagine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IMP,ISS] [PMID 8617224]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8617224]; GO_process: GO:0048313 - Golgi inheritance [Evidence IGI] [PMID 18595704]; GO_process: GO:0051645 - Golgi localization [Evidence IGI] [PMID 18595704]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8617224]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
3',5'-cyclic-nucleotide phosphodiesterase PDE1
similar to AA sequence:KEGG_Orthology:K01120
Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IEA]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IGI,IMP] [PMID 2824992]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IMP] [PMID 6300049]; GO_function: GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006198 - cAMP catabolic process [Evidence IEA]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IMP] [PMID 9880329]
similar to AA sequence:KEGG_Orthology:K02736
Beta 7 subunit of the 20S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17911101]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14263
Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004061 - arylformamidase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004061 - arylformamidase activity [Evidence IDA] [PMID 18205391]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA] [PMID 18205391]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA,IEA]; GO_process: GO:0019441 - tryptophan catabolic process to kynurenine [Evidence IEA,IEA]
Vacuolar protein involved in vacuolar membrane fusion tethering; plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p; GO_component: GO:0030897 - HOPS complex [Evidence IPI] [PMID 10944212]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11853670]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9111041]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 11062257]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IDA] [PMID 16601699]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0035542 - regulation of SNARE complex assembly [Evidence IDA] [PMID 18385512]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA] [PMID 18385512]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 10944212]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 9111041]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 12730205]
similar to AA sequence:KEGG_Orthology:K14554
Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 19150991]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IC] [PMID 15590835]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Inositol hexakisphosphate and inositol heptakisphosphate kinase; inositol heptakisphosphate (IP7) production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1; inositol hexakisphosphate is also known as IP6; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003993 - acid phosphatase activity [Evidence IEA]; GO_function: GO:0033857 - diphosphoinositol-pentakisphosphate kinase activity [Evidence IEA]; GO_function: GO:0000829 - inositol heptakisphosphate kinase activity [Evidence IDA] [PMID 17412958]; GO_function: GO:0052723 - inositol hexakisphosphate 1-kinase activity [Evidence IEA]; GO_function: GO:0052723 - inositol hexakisphosphate 1-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0052724 - inositol hexakisphosphate 3-kinase activity [Evidence IEA]; GO_function: GO:0052724 - inositol hexakisphosphate 3-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0000830 - inositol hexakisphosphate 4-kinase activity [Evidence IDA] [PMID 17412958]; GO_function: GO:0000830 - inositol hexakisphosphate 4-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0000832 - inositol hexakisphosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0000831 - inositol hexakisphosphate 6-kinase activity [Evidence IDA] [PMID 17412958]; GO_function: GO:0000831 - inositol hexakisphosphate 6-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IDA] [PMID 17412958]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
ribose phosphate diphosphokinase subunit PRS1
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11101685]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11548
Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p; GO_component: GO:0031262 - Ndc80 complex [Evidence IPI] [PMID 11179222]; GO_component: GO:0031262 - Ndc80 complex [Evidence IDA] [PMID 11266451]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA,IMP,IPI] [PMID 11179222]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA,IGI,IPI] [PMID 11266451]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11266451]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 8188751]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 11266451]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K02677
Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11545731]; GO_component: GO:0005856 - cytoskeleton [Evidence IDA] [PMID 15910746]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11545731]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0032165 - prospore septin filament array [Evidence IDA] [PMID 24390141]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 10893184]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IDA] [PMID 8207005]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IGI] [PMID 12810699]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 21163942]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IMP] [PMID 7874200]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8207005]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 7874200]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP] [PMID 21163942]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 7874200]
tetrafunctional fatty acid synthase subunit FAS1
similar to AA sequence:KEGG_Orthology:K00668
Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 6025308]; GO_component: GO:0005835 - fatty acid synthase complex [Evidence IEA]; GO_component: GO:0005835 - fatty acid synthase complex [Evidence IDA] [PMID 65153]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 17803462]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IEA]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IDA] [PMID 374077]; GO_function: GO:0047451 - 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [Evidence IEA]; GO_function: GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity [Evidence IDA] [PMID 374077]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IEA]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IDA] [PMID 365179]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IDA] [PMID 374077]; GO_function: GO:0016297 - acyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004318 - enoyl-[acyl-carrier-protein] reductase (NADH) activity [Evidence IEA,IEA]; GO_function: GO:0004319 - enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004319 - enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Evidence IDA] [PMID 374077]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IEA]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IMP] [PMID 65153]; GO_function: GO:0004321 - fatty-acyl-CoA synthase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016295 - myristoyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0004320 - oleoyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016296 - palmitoyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IDA] [PMID 365179]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 1735446]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 4127627]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007017 - microtubule-based process [Evidence IMP] [PMID 18064466]
similar to AA sequence:KEGG_Orthology:K11495
Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage; GO_component: GO:0043505 - centromere-specific nucleosome [Evidence IDA] [PMID 22693454]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21460225]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI] [PMID 19917722]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 16002464]; GO_process: GO:0043935 - sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 20713519]
similar to AA sequence:KEGG_Orthology:K00898
similar to AA sequence:KEGG_Orthology:K13338
AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 16911527]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 15634331]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 1825027]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IMP,IPI] [PMID 15634331]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16007078]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16911527]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA,IEA]; GO_process: GO:0016562 - protein import into peroxisome matrix, receptor recycling [Evidence IDA,IGI,IMP] [PMID 16007078]; GO_process: GO:0006625 - protein targeting to peroxisome [Evidence IEA]
DNA-directed RNA polymerase III core subunit RPO31
similar to AA sequence:KEGG_Orthology:K03018
RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11293
Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores; GO_component: GO:0000417 - HIR complex [Evidence IDA,IPI] [PMID 16264190]; GO_component: GO:0000417 - HIR complex [Evidence IDA] [PMID 16303565]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 11782447]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9504914]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16264190]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16264190]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IDA] [PMID 9001207]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0016568 - chromatin modification [Evidence IEA,IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9001207]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 16449659]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01293
Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 1569061]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IMP] [PMID 2026161]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004181 - metallocarboxypeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IMP] [PMID 2026161]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IMP] [PMID 2026161]
similar to AA sequence:KEGG_Orthology:K08827
mitochondrial 54S ribosomal protein MRPL51
similar to AA sequence:KEGG_Orthology:K17424
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
Uncharacterized protein C3orf60-like protein
proteasome regulatory particle lid subunit RPN6
similar to AA sequence:KEGG_Orthology:K03036
Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 12486135]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 12486135]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12486135]
transcription factor, zf-fungal binuclear cluster type (predicted)
pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
similar to AA sequence:KEGG_Orthology:K00167
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 8433986]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IMP] [PMID 8433986]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0004198 - calcium-dependent cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IDA] [PMID 9928935]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0016485 - protein processing [Evidence IGI,IMP] [PMID 9928935]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K05954
Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit; GO_component: GO:0005965 - protein farnesyltransferase complex [Evidence IEA]; GO_component: GO:0005965 - protein farnesyltransferase complex [Evidence IDA] [PMID 8424764]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IDA] [PMID 9380709]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0018343 - protein farnesylation [Evidence IEA]; GO_process: GO:0018343 - protein farnesylation [Evidence IDA] [PMID 1763050]; GO_process: GO:0042127 - regulation of cell proliferation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13127
General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; similar to S. pombe Cwf24p; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17974558]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IPI] [PMID 23029180]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IMP] [PMID 22535589]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 23029180]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 17974558]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 23029180]
proteasome regulatory particle base subunit RPT5
similar to AA sequence:KEGG_Orthology:K03065
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9584156]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9724628]
similar to AA sequence:KEGG_Orthology:K12816
Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IDA] [PMID 9769104]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IGI,IMP] [PMID 10999606]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17171376]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IGI,IMP] [PMID 10999606]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IGI] [PMID 10628969]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IGI] [PMID 15133121]; GO_process: GO:0000348 - mRNA branch site recognition [Evidence IGI] [PMID 15133121]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15262
Essential protein involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 12912920]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 12912920]; GO_process: GO:0006810 - transport [Evidence IEA]
Peroxisomal integral membrane protein; involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 14617799]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007031 - peroxisome organization [Evidence IMP] [PMID 14617799]
similar to AA sequence:KEGG_Orthology:K06316
Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IGI,IMP] [PMID 11807558]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0034202 - glycolipid-translocating activity [Evidence IDA] [PMID 18597486]; GO_function: GO:0034202 - glycolipid-translocating activity [Evidence IDA] [PMID 18668045]; GO_function: GO:0034202 - glycolipid-translocating activity [Evidence IMP] [PMID 19494107]; GO_function: GO:0005319 - lipid transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0034203 - glycolipid translocation [Evidence IGI,IMP] [PMID 11807558]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10601
similar to AA sequence:KEGG_Orthology:K03283
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 1394434]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 16413483]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9860955]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9670014]; GO_process: GO:0051083 - 'de novo' cotranslational protein folding [Evidence IDA] [PMID 9670014]; GO_process: GO:0042149 - cellular response to glucose starvation [Evidence IGI] [PMID 19723765]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP,IPI] [PMID 1394434]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 20368619]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 15456889]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IGI] [PMID 20368619]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 16607023]
Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family; GO_component: GO:0009898 - cytoplasmic side of plasma membrane [Evidence IDA] [PMID 20028738]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 9017390]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 9017390]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 9017390]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
similar to AA sequence:KEGG_Orthology:K15147
Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 19368889]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9671481]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9671481]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19368889]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16806052]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16806052]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 16806052]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 16702403]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15446
2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA,IMP] [PMID 17242307]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 17242307]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
bifunctional glutathione transferase/peroxidase
ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9792709]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 16709151]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IEA]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IDA,ISS] [PMID 9792709]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IDA] [PMID 9792709]
similar to AA sequence:KEGG_Orthology:K11251
Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15781691]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11252
Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11761
Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 14729968]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 14729968]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 2556404]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15961382]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence ISS] [PMID 15961382]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IGI,IMP] [PMID 15961382]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 10978274]; GO_process: GO:0006829 - zinc ion transport [Evidence IGI,IMP] [PMID 15961382]
similar to AA sequence:KEGG_Orthology:K00766
Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004048 - anthranilate phosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004048 - anthranilate phosphoribosyltransferase activity [Evidence ISS] [PMID 2428012]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]
Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 10747088]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA,IMP] [PMID 18287542]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 15039776]; GO_function: GO:0043130 - ubiquitin binding [Evidence IMP] [PMID 19574226]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 15039776]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP,IPI] [PMID 10747088]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 15039776]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11397
Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15353583]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 12672825]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0043623 - cellular protein complex assembly [Evidence IMP] [PMID 18212047]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IPI] [PMID 12672825]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17268
similar to AA sequence:KEGG_Orthology:K15437
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11726524]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15710377]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IMP,IPI] [PMID 9659920]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 11069915]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IMP,IPI] [PMID 11726524]; GO_process: GO:0051351 - positive regulation of ligase activity [Evidence IDA] [PMID 11069915]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IMP] [PMID 9659920]
similar to AA sequence:KEGG_Orthology:K15920
Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IDA] [PMID 10855721]; GO_process: GO:0006083 - acetate metabolic process [Evidence IDA] [PMID 10855721]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]
trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1
NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 19016485]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16575
Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3967297]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 6365930]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8163554]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 6217414]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 3967297]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 6365930]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 8163554]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 3967297]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 8163554]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 10911987]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IDA] [PMID 6217414]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA,IMP] [PMID 9732290]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA] [PMID 17118118]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17287397]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 15024029]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 9864365]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 10793147]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IMP] [PMID 8978821]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence TAS] [PMID 10652251]
similar to AA sequence:KEGG_Orthology:K18162
similar to AA sequence:KEGG_Orthology:K12197
Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11029042]; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11029042]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12194857]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 17130288]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 11029042]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12599
Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome; GO_component: GO:0055087 - Ski complex [Evidence IDA] [PMID 10744028]; GO_component: GO:0055087 - Ski complex [Evidence IDA,IPI] [PMID 18042677]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 8321235]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 10611222]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00031
Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15001388]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19854152]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0004450 - isocitrate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004450 - isocitrate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 15574419]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IEA]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IGI,IMP] [PMID 15574419]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
trifunctional formate-tetrahydrofolate ligase
similar to AA sequence:KEGG_Orthology:K00288
Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3528153]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IDA] [PMID 3528153]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IMP] [PMID 10781559]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23285234]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16390866]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23285234]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000753 - cell morphogenesis involved in conjugation with cellular fusion [Evidence IMP] [PMID 16390866]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IDA] [PMID 20850366]; GO_process: GO:0045048 - protein insertion into ER membrane [Evidence IGI] [PMID 19325107]
mitochondrial 54S ribosomal protein YmL3
Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16578
Component of the mitotic spindle; binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09272
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress; GO_component: GO:0035101 - FACT complex [Evidence IGI,IPI] [PMID 11432837]; GO_component: GO:0035101 - FACT complex [Evidence IDA] [PMID 9705338]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 10413469]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10413469]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10413469]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 18089575]; GO_function: GO:0031491 - nucleosome binding [Evidence IDA] [PMID 11432837]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0034724 - DNA replication-independent nucleosome organization [Evidence IDA] [PMID 15082784]; GO_process: GO:0034724 - DNA replication-independent nucleosome organization [Evidence IDA] [PMID 19683499]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IGI,IMP] [PMID 10924459]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IPI] [PMID 9199353]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 15987999]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IC] [PMID 19683500]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11739806]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11739806]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 11739806]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11739806]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IGI] [PMID 7822420]; GO_process: GO:0032596 - protein transport into membrane raft [Evidence IMP,IPI] [PMID 11739806]
similar to AA sequence:KEGG_Orthology:K11827
Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IDA,IPI] [PMID 10564262]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 8157009]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IC] [PMID 10564262]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01710
similar to AA sequence:KEGG_Orthology:K07300
Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 8628289]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20709757]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IMP] [PMID 20709757]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IDA,IMP] [PMID 8628289]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP] [PMID 20709757]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA,IMP] [PMID 8628289]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 8628289]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006828 - manganese ion transport [Evidence IDA] [PMID 15522090]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA,IMP] [PMID 8628289]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15272
similar to AA sequence:KEGG_Orthology:K06656
Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 7973730]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 14688790]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14688790]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 7973730]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 7973730]; GO_process: GO:0032878 - regulation of establishment or maintenance of cell polarity [Evidence IGI,IPI] [PMID 17853895]; GO_process: GO:0031106 - septin ring organization [Evidence IGI] [PMID 19458192]
Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 15591131]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15591131]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 15591131]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 15591131]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 15591131]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11673
Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity; GO_component: GO:0031011 - Ino80 complex [Evidence IEA]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 17320816]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 12887900]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 23644470]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 17320816]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09529
polyprotein of L1-like non-LTR retrotransposon Zorro 1
polyprotein of non-LTR retrotransposon Zorro 1 and repeat region-related DNA
similar to AA sequence:KEGG_Orthology:K02328
Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0043625 - delta DNA polymerase complex [Evidence TAS] [PMID 9745046]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 18635534]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence TAS] [PMID 9745046]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008310 - single-stranded DNA 3'-5' exodeoxyribonuclease activity [Evidence TAS] [PMID 9745046]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA] [PMID 16837458]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IDA] [PMID 17429354]; GO_process: GO:0006284 - base-excision repair [Evidence TAS] [PMID 9745046]; GO_process: GO:0006273 - lagging strand elongation [Evidence TAS] [PMID 9745046]; GO_process: GO:0006272 - leading strand elongation [Evidence TAS] [PMID 9745046]; GO_process: GO:0006298 - mismatch repair [Evidence TAS] [PMID 10072354]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence TAS] [PMID 9745046]; GO_process: GO:0006301 - postreplication repair [Evidence TAS] [PMID 9745046]
similar to AA sequence:KEGG_Orthology:K01874
Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 2645139]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IMP,ISS] [PMID 2645139]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IMP,ISS] [PMID 2645139]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14967
Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IMP] [PMID 11752412]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11687631]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IMP] [PMID 16921172]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IMP] [PMID 16980427]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 11742990]
Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 12052881]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 15256499]; GO_function: GO:0005034 - osmosensor activity [Evidence IMP] [PMID 12052881]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 19439450]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 2690082]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 17627274]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IGI] [PMID 17627274]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 12052881]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IEP,IGI,IMP] [PMID 15256499]
similar to AA sequence:KEGG_Orthology:K01760
Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 11565790]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence IEA,IEA]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence IMP,ISS] [PMID 10821189]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence IDA] [PMID 21478306]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0071266 - 'de novo' L-methionine biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 10821189]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 10821189]
similar to AA sequence:KEGG_Orthology:K12493
ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p; GO_component: GO:0030126 - COPI vesicle coat [Evidence IPI] [PMID 15254269]; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 15254269]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment [Evidence IPI] [PMID 9927415]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA] [PMID 9927415]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0048205 - COPI coating of Golgi vesicle [Evidence IDA,IMP] [PMID 15254269]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 9927415]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IGI,IMP] [PMID 9927415]; GO_process: GO:0006810 - transport [Evidence IEA]
subunit of NADH-ubiquinone oxidoreductase, mitochondrial precursor, putative
similar to AA sequence:KEGG_Orthology:K03943
mitochondrial 54S ribosomal protein MRP49
similar to AA sequence:KEGG_Orthology:K17440
Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 1544898]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 1544898]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1544898]
similar to AA sequence:KEGG_Orthology:K03783
Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 11466296]; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 17482543]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0047724 - inosine nucleosidase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0070635 - nicotinamide riboside hydrolase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0004731 - purine-nucleoside phosphorylase activity [Evidence IEA,IEA]; GO_function: GO:0004731 - purine-nucleoside phosphorylase activity [Evidence IDA,IMP,ISS] [PMID 11466296]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 19001417]; GO_process: GO:0046115 - guanosine catabolic process [Evidence IMP] [PMID 11466296]; GO_process: GO:0046115 - guanosine catabolic process [Evidence IMP] [PMID 23670538]; GO_process: GO:0006148 - inosine catabolic process [Evidence IMP] [PMID 11466296]; GO_process: GO:0006148 - inosine catabolic process [Evidence IMP] [PMID 23670538]; GO_process: GO:0019358 - nicotinate nucleotide salvage [Evidence IGI] [PMID 17482543]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14004
Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 11717432]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 12671686]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 17604721]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 22300850]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 8223424]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 8432727]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12538638]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 10747086]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IDA] [PMID 11389436]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA] [PMID 15817685]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03144
Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IPI] [PMID 10681587]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 19897425]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 9235928]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17678
Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 24206665]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 24206665]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12702275]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 24206665]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 9046088]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:1990400 - mitochondrial ribosomal large subunit rRNA binding [Evidence IDA] [PMID 24206665]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0016070 - RNA metabolic process [Evidence IMP] [PMID 12702275]; GO_process: GO:1902775 - mitochondrial large ribosomal subunit assembly [Evidence IMP] [PMID 24206665]
similar to AA sequence:KEGG_Orthology:K03108
Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0048500 - signal recognition particle [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 7925282]; GO_function: GO:0008312 - 7S RNA binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IPI] [PMID 7925282]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IC] [PMID 7925282]; GO_process: GO:0045047 - protein targeting to ER [Evidence IPI] [PMID 7925282]
similar to AA sequence:KEGG_Orthology:K07565
Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9271378]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9271378]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9271378]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 9271378]; GO_process: GO:0042255 - ribosome assembly [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06173
tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA; PUS1 has a paralog, PUS2, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 8641292]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA] [PMID 10356324]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IMP] [PMID 10022901]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA] [PMID 10356324]
similar to AA sequence:KEGG_Orthology:K14833
Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; GO_component: GO:0030690 - Noc1p-Noc2p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0030691 - Noc2p-Noc3p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23209026]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 23209026]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070628 - proteasome binding [Evidence IDA] [PMID 24121501]; GO_function: GO:0070628 - proteasome binding [Evidence IDA] [PMID 24297164]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071243 - cellular response to arsenic-containing substance [Evidence IGI,IMP] [PMID 24297164]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP,IPI] [PMID 24121501]
similar to AA sequence:KEGG_Orthology:K17796
Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 15797382]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 15878866]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 15797382]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02935
Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15221522]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence ISS] [PMID 9445368]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 15221522]; GO_process: GO:0006412 - translation [Evidence IEA]
Enhanced Adherence to Polystyrene; similar to S. pombe predicted GPI-anchored SPBPJ4664.02; similar to RBT1; internal hexapeptide PATEST repeat region is expanded in allelic CaP19.8979; identical to C. albicans morphogenetic related gene CPH3 (AAM46085); no clear allele
Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 8413233]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence IEA]; GO_process: GO:0006077 - (1->6)-beta-D-glucan metabolic process [Evidence IMP] [PMID 8413233]; GO_process: GO:0042546 - cell wall biogenesis [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 8413233]
similar to AA sequence:KEGG_Orthology:K17361
similar to AA sequence:KEGG_Orthology:K01288
Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 8308064]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence TAS] [PMID 8308064]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 23656787]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K18637
Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 8846915]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 8846915]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 8846915]
similar to AA sequence:KEGG_Orthology:K05294
GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8862519]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 8862519]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0050185 - phosphatidylinositol deacylase activity [Evidence IGI] [PMID 14734546]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8862519]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11673477]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IEA]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IGI] [PMID 14734546]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8862519]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IGI,IMP] [PMID 8862519]
similar to AA sequence:KEGG_Orthology:K11213
similar to AA sequence:KEGG_Orthology:K12839
CCR4-NOT core ubiquitin-protein ligase subunit MOT2
similar to AA sequence:KEGG_Orthology:K10643
Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 10490603]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11889048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16926149]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 19346402]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0031087 - deadenylation-independent decapping of nuclear-transcribed mRNA [Evidence IMP] [PMID 15706350]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11404327]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0010498 - proteasomal protein catabolic process [Evidence IGI] [PMID 24261871]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA,IMP] [PMID 19346402]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 16926149]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03936
EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 10594004]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence TAS] [PMID 10652251]; GO_process: GO:0007015 - actin filament organization [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 15944351]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006897 - endocytosis [Evidence IEA,IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8380177]
similar to AA sequence:KEGG_Orthology:K07937
ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 20841378]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8816753]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20444982]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
H(+)-transporting V1 sector ATPase subunit A
similar to AA sequence:KEGG_Orthology:K02145
Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 18632794]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 7775427]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0004520 - endodeoxyribonuclease activity [Evidence TAS] [PMID 1534148]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IDA] [PMID 8508780]; GO_process: GO:0016539 - intein-mediated protein splicing [Evidence IEA]; GO_process: GO:0006314 - intron homing [Evidence IEA]; GO_process: GO:0006314 - intron homing [Evidence TAS] [PMID 1534148]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0030908 - protein splicing [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 18048916]
phosphoprotein phosphatase 2A catalytic subunit PPH21
similar to AA sequence:KEGG_Orthology:K04382
Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IMP] [PMID 2176150]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 12518319]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 9001215]; GO_process: GO:0007117 - budding cell bud growth [Evidence TAS] [PMID 9001215]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IPI] [PMID 9001215]; GO_process: GO:0006470 - protein dephosphorylation [Evidence TAS] [PMID 9001215]; GO_process: GO:0006417 - regulation of translation [Evidence IPI] [PMID 10329624]
similar to AA sequence:KEGG_Orthology:K12462
Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15108020]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 15108020]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10066831]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005094 - Rho GDP-dissociation inhibitor activity [Evidence IEA]; GO_function: GO:0005094 - Rho GDP-dissociation inhibitor activity [Evidence IDA] [PMID 10066831]; GO_process: GO:0007015 - actin filament organization [Evidence IDA,IMP] [PMID 9242378]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA] [PMID 11598008]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IPI] [PMID 10066831]
similar to AA sequence:KEGG_Orthology:K10597
Ubiquitin chain assembly factor (E4); cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0034450 - ubiquitin-ubiquitin ligase activity [Evidence IEA]; GO_function: GO:0034450 - ubiquitin-ubiquitin ligase activity [Evidence IDA] [PMID 10089879]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21148305]; GO_process: GO:0071361 - cellular response to ethanol [Evidence IMP] [PMID 10089879]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA,IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 10089879]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 10089879]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 7615550]
[acyl-carrier-protein] S-malonyltransferase
similar to AA sequence:KEGG_Orthology:K00645
Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 9388293]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IEA]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IMP,ISS] [PMID 9388293]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9388293]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IMP,ISS] [PMID 9388293]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
hypothetical protein; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10366589]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 15623581]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IDA] [PMID 10366589]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 10366589]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 15623581]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14536
Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11779510]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11779510]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0042256 - mature ribosome assembly [Evidence IMP] [PMID 11779510]; GO_process: GO:0042256 - mature ribosome assembly [Evidence ISO] [PMID 21536732]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12628189]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12628189]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12628189]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12628189]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007093 - mitotic cell cycle checkpoint [Evidence IMP] [PMID 12628189]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IGI,IMP] [PMID 12628189]
similar to AA sequence:KEGG_Orthology:K07050
hypothetical protein; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increased readthrough of premature stop codons; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004813 - alanine-tRNA ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006419 - alanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10245
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12087109]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0009922 - fatty acid elongase activity [Evidence IMP] [PMID 12684876]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0030497 - fatty acid elongation [Evidence IMP] [PMID 9211877]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 9211877]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 9832547]
Subunit of the Set3C deacetylase complex; interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IPI] [PMID 11711434]; GO_process: GO:0032874 - positive regulation of stress-activated MAPK cascade [Evidence IMP] [PMID 18487345]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 19379692]
similar to AA sequence:KEGG_Orthology:K00877
Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_function: GO:0008902 - hydroxymethylpyrimidine kinase activity [Evidence IGI] [PMID 15614489]; GO_function: GO:0008972 - phosphomethylpyrimidine kinase activity [Evidence ISA] [PMID 10383756]; GO_function: GO:0008972 - phosphomethylpyrimidine kinase activity [Evidence IGI] [PMID 15614489]; GO_function: GO:0050334 - thiaminase activity [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEP] [PMID 10383756]; GO_process: GO:0006772 - thiamine metabolic process [Evidence IEA]
Zinc-finger hypothetical protein; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IDA] [PMID 19111667]; GO_process: GO:0008150 - biological_process [Evidence ND]
putative mitochondrial Complex I, NUKM_20kd subunit
similar to AA sequence:KEGG_Orthology:K03940
potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUKM subunit and mammalian PSST, CI-20kd or NDUFS7 subunit; allele of CaO19.6794
similar to AA sequence:KEGG_Orthology:K01210
Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IEA]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006073 - cellular glucan metabolic process [Evidence IGI,IMP] [PMID 7565587]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence ISS] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051293 - establishment of spindle localization [Evidence IGI,IMP] [PMID 22385961]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 16888627]; GO_process: GO:0045132 - meiotic chromosome segregation [Evidence IMP] [PMID 16888627]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000073 - spindle pole body separation [Evidence IMP] [PMID 22385961]
bifunctional urea carboxylase/allophanate hydrolase
similar to AA sequence:KEGG_Orthology:K01968
Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IMP] [PMID 6105114]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IMP] [PMID 6105114]; GO_process: GO:0000256 - allantoin catabolic process [Evidence TAS] [PMID 1938916]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IMP] [PMID 6105114]
Protein that negatively regulates mitotic exit; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL2 has a paralog, KEL1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9786949]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9786949]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9786949]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IGI] [PMID 9786949]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IMP,IPI] [PMID 12234925]
filamentous hemagglutinin family outer membrane protein
similar to AA sequence:KEGG_Orthology:K10256
one of two likely delta-12 fatty acid desaturases similar to E.nudulans OdeA; conversion of oleic acid to linoleic acid, psi factor production; allele of CaO19.118
similar to AA sequence:KEGG_Orthology:K12586
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9891085]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9891085]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 9891085]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12364597]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18940861]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 12364597]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 10051608]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 10397776]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IPI] [PMID 10051608]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IDA] [PMID 12221072]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 10051608]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA,IMP] [PMID 10469659]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IDA] [PMID 10051608]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IDA,IMP] [PMID 10469659]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00852
Putative ribokinase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence ISS] [PMID 1964349]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0004747 - ribokinase activity [Evidence IEA,IEA]; GO_function: GO:0004747 - ribokinase activity [Evidence ISS] [PMID 1964349]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019303 - D-ribose catabolic process [Evidence IEA]; GO_process: GO:0006014 - D-ribose metabolic process [Evidence IEA]; GO_process: GO:0006014 - D-ribose metabolic process [Evidence ISS] [PMID 1964349]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11835
Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15378
putative E3 ubiquitin-protein ligase HUL4
similar to AA sequence:KEGG_Orthology:K12232
Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IBA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISS] [PMID 9858558]; GO_process: GO:0016567 - protein ubiquitination [Evidence ISS] [PMID 9858558]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K01057
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15454531]; GO_function: GO:0017057 - 6-phosphogluconolactonase activity [Evidence IDA] [PMID 15454531]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 15454531]
similar to AA sequence:KEGG_Orthology:K03657
similar to AA sequence:KEGG_Orthology:K08735
Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; GO_component: GO:0032301 - MutSalpha complex [Evidence IEA]; GO_component: GO:0032301 - MutSalpha complex [Evidence IPI] [PMID 8816473]; GO_component: GO:0032302 - MutSbeta complex [Evidence IEA]; GO_component: GO:0032302 - MutSbeta complex [Evidence IPI] [PMID 8805366]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 10882115]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 9545323]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9819445]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 8805366]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0000403 - Y-form DNA binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0000406 - double-strand/single-strand DNA junction binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 10066781]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 9018043]; GO_function: GO:0032137 - guanine/thymine mispair binding [Evidence IDA] [PMID 8816473]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IDA] [PMID 8816473]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IMP] [PMID 9111312]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 15920474]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 16157874]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IBA]; GO_process: GO:0006311 - meiotic gene conversion [Evidence IMP] [PMID 1334021]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 1334021]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 8056309]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 10523644]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9520271]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 8849883]; GO_process: GO:0045128 - negative regulation of reciprocal meiotic recombination [Evidence IBA]; GO_process: GO:0006301 - postreplication repair [Evidence IBA]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IMP] [PMID 10523644]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IGI,IMP] [PMID 9256462]
Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10848632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10848632]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 7493987]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 8422683]; GO_process: GO:0071400 - cellular response to oleic acid [Evidence IMP] [PMID 12393187]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IDA] [PMID 7493987]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 8422683]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12393187]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7493987]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8422683]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
succinate dehydrogenase assembly factor SDH5
similar to AA sequence:KEGG_Orthology:K18168
similar to AA sequence:KEGG_Orthology:K17908
similar to AA sequence:KEGG_Orthology:K18185
Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15145942]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15145942]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033108 - mitochondrial respiratory chain complex assembly [Evidence IMP] [PMID 19703468]
similar to AA sequence:KEGG_Orthology:K07511
3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IDA,ISS] [PMID 12697341]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12697341]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006574 - valine catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17768
similar to AA sequence:KEGG_Orthology:K00624
Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18427809]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 18427809]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence IMP,ISS] [PMID 8420957]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0009437 - carnitine metabolic process [Evidence IMP] [PMID 11329169]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A; GO_component: GO:0043189 - H4/H2A histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15353583]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 15353583]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IPI] [PMID 15353583]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 15353583]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP,IPI] [PMID 15353583]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15172
Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; GO_component: GO:0032044 - DSIF complex [Evidence IPI] [PMID 9450930]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1840633]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 16908835]; GO_function: GO:0001042 - RNA polymerase I core binding [Evidence IPI] [PMID 21467036]; GO_function: GO:0001179 - RNA polymerase I transcription factor binding [Evidence IPI] [PMID 21467036]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 9450930]; GO_function: GO:0001181 - core RNA polymerase I binding transcription factor activity [Evidence IC] [PMID 21467036]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IGI,IMP,IPI] [PMID 9450930]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 21467036]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IGI,IPI] [PMID 12556496]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 20713510]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12556496]; GO_process: GO:2001208 - negative regulation of transcription elongation from RNA polymerase I promoter [Evidence IGI] [PMID 21467039]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 21467039]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 19365074]; GO_process: GO:0032784 - regulation of DNA-templated transcription, elongation [Evidence IEA]; GO_process: GO:2000232 - regulation of rRNA processing [Evidence IMP] [PMID 21949810]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 20042611]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00688
Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; expression is regulated by stress-response elements and by the HOG MAP kinase pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24146988]; GO_function: GO:0008184 - glycogen phosphorylase activity [Evidence IEA]; GO_function: GO:0008184 - glycogen phosphorylase activity [Evidence IMP] [PMID 2657401]; GO_function: GO:0004645 - phosphorylase activity [Evidence IEA,IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IMP] [PMID 2657401]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09494
Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12554655]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 12048214]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 12048214]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 15659643]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 12048214]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12554655]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI,IMP,IPI] [PMID 12554655]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 12048214]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17298444]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17298444]; GO_function: GO:0052874 - FMN reductase (NADH) activity [Evidence IEA]; GO_function: GO:0052873 - FMN reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0003955 - NAD(P)H dehydrogenase (quinone) activity [Evidence IDA,IMP] [PMID 17298444]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008134 - transcription factor binding [Evidence IDA] [PMID 19029946]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 19709309]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17298444]; GO_process: GO:0042994 - cytoplasmic sequestering of transcription factor [Evidence IDA] [PMID 19029946]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11768
Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 9844636]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 9726966]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 9844636]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA,IDA] [PMID 12183366]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence IGI] [PMID 12805231]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 17496903]; GO_process: GO:0016584 - nucleosome positioning [Evidence IMP] [PMID 21343911]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9726966]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11268
Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress; GO_component: GO:0000785 - chromatin [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 9990856]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16962805]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0016407 - acetyltransferase activity [Evidence IDA] [PMID 11864574]; GO_function: GO:0016407 - acetyltransferase activity [Evidence IDA] [PMID 18614053]; GO_function: GO:0016407 - acetyltransferase activity [Evidence IDA,IMP] [PMID 22593213]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9990856]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11448778]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 9990856]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IMP] [PMID 19948494]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 11448778]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IGI] [PMID 16934511]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 9990855]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 9990856]; GO_process: GO:0018393 - internal peptidyl-lysine acetylation [Evidence IDA] [PMID 18614053]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 19948494]; GO_process: GO:0034421 - post-translational protein acetylation [Evidence IEA]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IEA]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IGI] [PMID 9990855]; GO_process: GO:0007088 - regulation of mitosis [Evidence IMP] [PMID 9990855]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IEA]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 19948494]; GO_process: GO:0032200 - telomere organization [Evidence IMP] [PMID 19948494]
similar to AA sequence:KEGG_Orthology:K13950
Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0046820 - 4-amino-4-deoxychorismate synthase activity [Evidence IEA]; GO_function: GO:0046820 - 4-amino-4-deoxychorismate synthase activity [Evidence IMP,ISS] [PMID 8346682]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016833 - oxo-acid-lyase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0008153 - para-aminobenzoic acid biosynthetic process [Evidence IMP] [PMID 8346682]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]
mitochondrial 54S ribosomal protein YmL27
similar to AA sequence:KEGG_Orthology:K17422
Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
putative mitochondrial Complex I, 40kd subunit
similar to AA sequence:KEGG_Orthology:K03953
potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa and mammalian 40kd subunits; allele of CaO19.1682
similar to AA sequence:KEGG_Orthology:K00888
Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective autophagy and mitophagy through trafficking of Atg9p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10587649]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16365163]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8194527]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 10587649]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16365163]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA,IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IMP] [PMID 10587649]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 8194527]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 8248783]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IMP] [PMID 10587649]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 8194527]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 8248783]; GO_process: GO:0048015 - phosphatidylinositol-mediated signaling [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog, TDA6, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Polysialic acid capsule expression protein
similar to AA sequence:KEGG_Orthology:K14303
Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0032133 - chromosome passenger complex [Evidence IDA] [PMID 19158380]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 12566427]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IMP,IPI] [PMID 10385519]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence TAS] [PMID 11724818]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP,IPI] [PMID 10385519]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 17504936]; GO_process: GO:0032465 - regulation of cytokinesis [Evidence IMP] [PMID 16615892]
TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 9819421]; GO_function: GO:0030544 - Hsp70 protein binding [Evidence IDA] [PMID 15044454]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 12788914]; GO_process: GO:0006457 - protein folding [Evidence IPI] [PMID 15044454]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 9819421]
Mediator of RNA polymerase II transcription subunit 12
similar to AA sequence:KEGG_Orthology:K15163
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 11383511]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 12200444]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001105 - RNA polymerase II transcription coactivator activity [Evidence IDA,IMP] [PMID 20505076]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16109375]; GO_process: GO:0000411 - positive regulation of transcription by galactose [Evidence IMP] [PMID 15601835]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15601835]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04802
Proliferating cell nuclear antigen (PCNA); functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; GO_component: GO:0043626 - PCNA complex [Evidence IEA]; GO_component: GO:0043626 - PCNA complex [Evidence IPI] [PMID 8001157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 12015307]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0030337 - DNA polymerase processivity factor activity [Evidence IEA]; GO_function: GO:0030337 - DNA polymerase processivity factor activity [Evidence IDA] [PMID 18635534]; GO_function: GO:0030337 - DNA polymerase processivity factor activity [Evidence IDA] [PMID 2902631]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 10545450]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16157874]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 16157874]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IGI] [PMID 19264809]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IGI] [PMID 16934511]; GO_process: GO:0006273 - lagging strand elongation [Evidence IDA,IPI] [PMID 7673186]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1682321]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IGI,IMP] [PMID 16079237]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IGI,IMP] [PMID 18245822]; GO_process: GO:0006298 - mismatch repair [Evidence IMP,IPI] [PMID 8858149]; GO_process: GO:0006298 - mismatch repair [Evidence IGI] [PMID 8910404]; GO_process: GO:0006298 - mismatch repair [Evidence IGI] [PMID 9504910]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IGI] [PMID 7516465]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IPI] [PMID 16934511]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 9806417]; GO_process: GO:1902394 - positive regulation of exodeoxyribonuclease activity [Evidence IDA] [PMID 12192046]; GO_process: GO:1903022 - positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [Evidence IDA] [PMID 12192046]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IMP] [PMID 8790390]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02542
Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0097373 - MCM core complex [Evidence IDA] [PMID 13679365]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15723534]; GO_function: GO:1990163 - ATP-dependent four-way junction helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 15723534]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IPI] [PMID 9335335]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 13679365]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 15723534]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]
hypothetical protein that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K03115
Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IEA]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IEA]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IMP] [PMID 11827175]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IPI] [PMID 8135547]; GO_function: GO:0030291 - protein serine/threonine kinase inhibitor activity [Evidence IDA] [PMID 18265947]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 16607517]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0045859 - regulation of protein kinase activity [Evidence IEA]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase
similar to AA sequence:KEGG_Orthology:K00838
Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IEA]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 9491082]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009094 - L-phenylalanine biosynthetic process [Evidence IEA]; GO_process: GO:0009072 - aromatic amino acid family metabolic process [Evidence IGI,IMP] [PMID 9491083]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03364
Activator of anaphase-promoting complex/cyclosome (APC/C); cell-cycle regulated; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IPI] [PMID 9831566]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12456658]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12456658]; GO_function: GO:0010997 - anaphase-promoting complex binding [Evidence IDA] [PMID 15916961]; GO_function: GO:0030332 - cyclin binding [Evidence IDA] [PMID 11566880]; GO_function: GO:0097027 - ubiquitin-protein transferase activator activity [Evidence IDA] [PMID 19362536]; GO_process: GO:0007092 - activation of mitotic anaphase-promoting complex activity [Evidence IMP] [PMID 9334304]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0010697 - negative regulation of spindle pole body separation [Evidence IGI,IMP] [PMID 16688214]; GO_process: GO:2000600 - positive regulation of cyclin catabolic process [Evidence IDA] [PMID 17178718]; GO_process: GO:0045842 - positive regulation of mitotic metaphase/anaphase transition [Evidence IMP] [PMID 9831566]; GO_process: GO:2000060 - positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 18172166]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]
similar to AA sequence:KEGG_Orthology:K16945
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 17603111]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 18431499]; GO_process: GO:0000915 - actomyosin contractile ring assembly [Evidence IMP] [PMID 17603111]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 17603111]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0032186 - cellular bud neck septin ring organization [Evidence IMP] [PMID 12636916]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 12699621]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI] [PMID 17603111]
similar to AA sequence:KEGG_Orthology:K01867
Mitochondrial tryptophanyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 2999114]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IMP,ISA] [PMID 2999114]; GO_process: GO:0070183 - mitochondrial tryptophanyl-tRNA aminoacylation [Evidence IMP] [PMID 2999114]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation [Evidence IEA]
Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p); GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 16207709]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 16207709]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IGI] [PMID 14514677]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IGI] [PMID 16207709]; GO_process: GO:0007006 - mitochondrial membrane organization [Evidence IMP] [PMID 11488609]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein; GO_component: GO:0097361 - CIA complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16314508]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16314508]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI,IMP] [PMID 17937914]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K14961
Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 15056729]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IPI] [PMID 14690591]; GO_process: GO:0006364 - rRNA processing [Evidence IMP,IPI] [PMID 15056729]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
protein phosphatase 2A regulatory subunit RTS1
similar to AA sequence:KEGG_Orthology:K11584
B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12388751]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12636916]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA] [PMID 16541024]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000776 - kinetochore [Evidence IDA] [PMID 12636916]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12388751]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12636916]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12388751]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IDA] [PMID 9079645]; GO_process: GO:0032186 - cellular bud neck septin ring organization [Evidence IGI,IMP] [PMID 12636916]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 19605686]; GO_process: GO:0051754 - meiotic sister chromatid cohesion, centromeric [Evidence IMP] [PMID 16541024]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI] [PMID 19605686]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 19605686]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 22581371]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0031107 - septin ring disassembly [Evidence IMP] [PMID 12636916]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10357
Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication; GO_component: GO:0071563 - Myo2p-Vac17p-Vac8p transport complex [Evidence IPI] [PMID 12594460]; GO_component: GO:0032432 - actin filament bundle [Evidence IMP] [PMID 9864365]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8188749]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8188749]; GO_component: GO:0031941 - filamentous actin [Evidence IDA] [PMID 11381095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8978821]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8188749]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 8188749]; GO_component: GO:0031475 - myosin V complex [Evidence ISS] [PMID 1469047]; GO_component: GO:0016459 - myosin complex [Evidence IEA,IEA]; GO_component: GO:0030133 - transport vesicle [Evidence IDA] [PMID 23079598]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 12456647]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 11381095]; GO_function: GO:0005516 - calmodulin binding [Evidence IEA]; GO_function: GO:0005516 - calmodulin binding [Evidence IDA] [PMID 8294515]; GO_function: GO:0000146 - microfilament motor activity [Evidence IDA] [PMID 11381095]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0048313 - Golgi inheritance [Evidence IMP] [PMID 11285273]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 2016335]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP,IPI] [PMID 10984058]; GO_process: GO:0007107 - membrane addition at site of cytokinesis [Evidence IEP,IGI,IMP] [PMID 12456647]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 12391144]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IPI] [PMID 15201867]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IMP] [PMID 11733545]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IPI] [PMID 16678774]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0009826 - unidimensional cell growth [Evidence IMP] [PMID 9864365]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IPI] [PMID 12594460]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IMP] [PMID 8978821]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence IEP,IMP] [PMID 10562281]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence IEP,IMP] [PMID 9864365]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 2016335]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 9864365]
similar to AA sequence:KEGG_Orthology:K03680
Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IGI] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IGI] [PMID 8336705]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI] [PMID 8164676]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI,IPI] [PMID 8887689]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 9032257]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 2038326]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IGI] [PMID 8336705]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0045947 - negative regulation of translational initiation [Evidence IBA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI] [PMID 8164676]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8887689]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 9032257]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02437
H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF; GO_component: GO:0005960 - glycine cleavage complex [Evidence IEA]; GO_component: GO:0005960 - glycine cleavage complex [Evidence ISA] [PMID 9020168]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19570983]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IMP,ISA] [PMID 9020168]; GO_process: GO:0006546 - glycine catabolic process [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IMP] [PMID 9020168]; GO_process: GO:0019464 - glycine decarboxylation via glycine cleavage system [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI] [PMID 10871621]; GO_process: GO:0009249 - protein lipoylation [Evidence IMP] [PMID 19570983]
bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase
similar to AA sequence:KEGG_Orthology:K19030
Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IEA,IEA]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence NAS] [PMID 15494396]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence NAS] [PMID 15494396]; GO_process: GO:0006000 - fructose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006110 - regulation of glycolytic process [Evidence NAS] [PMID 15494396]
Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16717099]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9046099]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015230 - FAD transmembrane transporter activity [Evidence ISS] [PMID 16717099]; GO_process: GO:0015883 - FAD transport [Evidence ISS] [PMID 16717099]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 16717099]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02180
Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IPI] [PMID 12221113]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IPI] [PMID 10704439]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IDA,IPI] [PMID 11726501]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence TAS] [PMID 9448456]
adenosylmethionine-8-amino-7-oxononanoate transaminase
similar to AA sequence:KEGG_Orthology:K19562
7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 10333520]; GO_function: GO:0004015 - adenosylmethionine-8-amino-7-oxononanoate transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004015 - adenosylmethionine-8-amino-7-oxononanoate transaminase activity [Evidence IDA,ISS] [PMID 10333520]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IDA,IMP] [PMID 10333520]
similar to AA sequence:KEGG_Orthology:K03024
RNA polymerase III subunit C31; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 2201900]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006384 - transcription initiation from RNA polymerase III promoter [Evidence IMP] [PMID 7835345]
similar to AA sequence:KEGG_Orthology:K07277
similar to AA sequence:KEGG_Orthology:K03381
similar to AA sequence:KEGG_Orthology:K17783
Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 11493598]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016971 - flavin-linked sulfhydryl oxidase activity [Evidence IDA] [PMID 10899311]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016972 - thiol oxidase activity [Evidence IEA,IEA]; GO_function: GO:0016972 - thiol oxidase activity [Evidence IMP] [PMID 15989955]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IDA] [PMID 11493598]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15989955]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 15989955]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 16181637]
Proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP); GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9412475]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9412475]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9412475]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IPI] [PMID 9412475]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 9412475]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 9412475]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 9412475]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9742397]; GO_process: GO:0032465 - regulation of cytokinesis [Evidence IMP] [PMID 15941409]
similar to AA sequence:KEGG_Orthology:K00706
Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IEA]; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 7983071]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8602515]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11856368]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8602515]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11856368]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IEA,IEA]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA,IMP] [PMID 7528927]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA] [PMID 7649185]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 7528927]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0008360 - regulation of cell shape [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]
Mitochondrial protein involved in mitochondrial protein sorting; putative membrane-spanning ATPase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 8226973]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8226973]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IGI] [PMID 8226973]
alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1
similar to AA sequence:KEGG_Orthology:K00697
Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IDA,IMP] [PMID 1425702]; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IGI,IMP,IPI] [PMID 9837904]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003825 - alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [Evidence IEA,IEA]; GO_function: GO:0003825 - alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [Evidence IDA,IMP] [PMID 1425702]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IDA,IMP] [PMID 1425702]; GO_process: GO:0034605 - cellular response to heat [Evidence IDA] [PMID 9660948]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11483159]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IDA,IMP] [PMID 1425702]
similar to AA sequence:KEGG_Orthology:K01657
Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p; GO_component: GO:0005950 - anthranilate synthase complex [Evidence IPI] [PMID 3881257]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IDA] [PMID 3881257]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IGI,ISS] [PMID 6323449]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016833 - oxo-acid-lyase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 8432699]
similar to AA sequence:KEGG_Orthology:K14803
Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 10580002]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IGI] [PMID 10747050]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP,IPI] [PMID 9528768]; GO_process: GO:0000173 - inactivation of MAPK activity involved in osmosensory signaling pathway [Evidence IGI] [PMID 11113180]; GO_process: GO:0000173 - inactivation of MAPK activity involved in osmosensory signaling pathway [Evidence IDA,IGI,IMP] [PMID 12477803]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 10580002]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 12477803]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IMP,IPI] [PMID 10580002]
similar to AA sequence:KEGG_Orthology:K03424
3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008296 - 3'-5'-exodeoxyribonuclease activity [Evidence IDA] [PMID 15657035]; GO_function: GO:0016888 - endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IDA] [PMID 15657035]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0006309 - apoptotic DNA fragmentation [Evidence IMP] [PMID 15657035]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15657035]
oxysterol-binding protein related protein OSH7
Oxysterol-binding protein; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 20008566]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16096648]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 16096648]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0016125 - sterol metabolic process [Evidence IGI] [PMID 16096648]; GO_process: GO:0015918 - sterol transport [Evidence IGI] [PMID 16585271]; GO_process: GO:0006810 - transport [Evidence IEA]
Nonessential hypothetical protein; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
hypothetical protein; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
UTP glucose-1-phosphate uridylyltransferase
similar to AA sequence:KEGG_Orthology:K00963
UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003983 - UTP:glucose-1-phosphate uridylyltransferase activity [Evidence IEA]; GO_function: GO:0003983 - UTP:glucose-1-phosphate uridylyltransferase activity [Evidence IMP,ISS] [PMID 7588797]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0070569 - uridylyltransferase activity [Evidence IDA] [PMID 22580055]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 17531808]; GO_process: GO:0006011 - UDP-glucose metabolic process [Evidence IMP] [PMID 7588797]; GO_process: GO:0006011 - UDP-glucose metabolic process [Evidence IGI,IMP] [PMID 9252577]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI,IMP] [PMID 9252577]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IGI] [PMID 9252577]
similar to AA sequence:KEGG_Orthology:K03469
Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 7489497]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9759502]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA,IEA]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IDA] [PMID 7489497]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0006401 - RNA catabolic process [Evidence IDA] [PMID 7489497]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 17576801]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17576801]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17576801]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14690591]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19075114]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0090002 - establishment of protein localization to plasma membrane [Evidence IDA] [PMID 19075114]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IDA,IMP] [PMID 17576801]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IDA] [PMID 17576801]; GO_process: GO:0019236 - response to pheromone [Evidence IDA] [PMID 17576801]
top hit is XP_963644.2 originated in Neurospora crassa OR74A
polyprotein of L1-like non-LTR retrotransposon Zorro 3
similar to AA sequence:KEGG_Orthology:K10841
Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 8702468]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0001208 - histone H2A-H2B dimer displacement [Evidence IMP] [PMID 22199252]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI] [PMID 17023424]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 17023424]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 7957102]
similar to AA sequence:KEGG_Orthology:K07513
3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 7754706]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA,IMP,ISM] [PMID 8125978]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 19470242]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IEA]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IDA] [PMID 7754706]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13830
Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00480
similar to AA sequence:KEGG_Orthology:K01027
General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 12499351]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15039776]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 15039776]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 9199164]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IMP] [PMID 14523026]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15707981]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 6759873]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 15707981]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 6759873]; GO_process: GO:0015846 - polyamine transport [Evidence IMP] [PMID 15707981]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 17908202]; GO_component: GO:0033101 - cellular bud membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence ISS] [PMID 10559922]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 10559922]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009966 - regulation of signal transduction [Evidence IMP,IPI] [PMID 12477731]
Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 16478783]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 16478783]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 1512289]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 7615633]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 16478783]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IDA] [PMID 10022848]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
mitogen-activated protein kinase kinase kinase BCK1
similar to AA sequence:KEGG_Orthology:K11229
mitochondrial 54S ribosomal protein YmL49
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
similar to AA sequence:KEGG_Orthology:K06030
Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 11266460]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 9685359]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 9786948]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11266460]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 19812251]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 16624808]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IEA]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP,IPI] [PMID 12808034]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP] [PMID 9786948]; GO_process: GO:0051646 - mitochondrion localization [Evidence IGI] [PMID 23341591]
Fungal Genetics Stock Center 12732; Fungal Genetics Stock Center 12731
similar to AA sequence:KEGG_Orthology:K11375
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IEA]; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 22343726]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 22343726]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03362
Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IDA] [PMID 9990311]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IMP] [PMID 11839781]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA] [PMID 15772160]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IEA]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IMP] [PMID 22573892]
similar to AA sequence:KEGG_Orthology:K07152
Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 1944230]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 11546815]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence ISS] [PMID 10954195]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IEA]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006825 - copper ion transport [Evidence IGI,ISS] [PMID 8662933]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 2835635]; GO_process: GO:0008535 - respiratory chain complex IV assembly [Evidence IEA]; GO_process: GO:0051775 - response to redox state [Evidence ISS] [PMID 15659396]
similar to AA sequence:KEGG_Orthology:K06867
Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA,IGI] [PMID 22570489]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 22570489]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP,IPI] [PMID 22570489]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI,IMP] [PMID 15611164]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IGI,IMP] [PMID 22570489]
Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K08269
similar to AA sequence:KEGG_Orthology:K11294
Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 19861225]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 7800479]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence TAS] [PMID 10690410]
similar to AA sequence:KEGG_Orthology:K14544
Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IC] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 23194188]
similar to AA sequence:KEGG_Orthology:K17800
Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA,ISS] [PMID 16476776]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006813 - potassium ion transport [Evidence IGI] [PMID 20197279]; GO_process: GO:0051204 - protein insertion into mitochondrial membrane [Evidence IMP] [PMID 16476776]; GO_process: GO:0015992 - proton transport [Evidence IGI] [PMID 20197279]
similar to AA sequence:KEGG_Orthology:K01520
deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0035870 - dITP diphosphatase activity [Evidence IDA] [PMID 21548881]; GO_function: GO:0004170 - dUTP diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004170 - dUTP diphosphatase activity [Evidence IDA,IMP] [PMID 21548881]; GO_function: GO:0004170 - dUTP diphosphatase activity [Evidence IMP] [PMID 8223452]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0035863 - dITP catabolic process [Evidence IDA] [PMID 21548881]; GO_process: GO:0006226 - dUMP biosynthetic process [Evidence IEA]; GO_process: GO:0046081 - dUTP catabolic process [Evidence IDA,IMP] [PMID 21548881]; GO_process: GO:0046080 - dUTP metabolic process [Evidence IEA]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]; GO_process: GO:0009213 - pyrimidine deoxyribonucleoside triphosphate catabolic process [Evidence IMP] [PMID 8223452]
similar to AA sequence:KEGG_Orthology:K17979
Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15631992]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 16020778]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP] [PMID 15631992]; GO_process: GO:0007005 - mitochondrion organization [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 11907266]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 16020778]; GO_process: GO:1900208 - regulation of cardiolipin metabolic process [Evidence IGI] [PMID 22403410]
Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IDA] [PMID 7493316]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 7493316]
similar to AA sequence:KEGG_Orthology:K17983
Protein required for normal mitochondrial morphology; mitochondrial inner membrane protein; may be involved in fission of the inner membrane; forms a homo-oligomeric complex; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12591915]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007007 - inner mitochondrial membrane organization [Evidence IGI,IMP] [PMID 12591915]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 11907266]
proteasome regulatory particle base subunit RPT3
similar to AA sequence:KEGG_Orthology:K03063
ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9584156]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9724628]
hypothetical protein; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K07101
Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004422 - hypoxanthine phosphoribosyltransferase activity [Evidence IGI] [PMID 10217799]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0000310 - xanthine phosphoribosyltransferase activity [Evidence IMP] [PMID 10217799]; GO_process: GO:0032265 - XMP salvage [Evidence IMP] [PMID 10217799]; GO_process: GO:0046100 - hypoxanthine metabolic process [Evidence IGI] [PMID 10217799]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14546
Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0017054 - negative cofactor 2 complex [Evidence IDA] [PMID 8948634]; GO_component: GO:0017054 - negative cofactor 2 complex [Evidence IPI] [PMID 9023340]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21976730]; GO_function: GO:0001132 - TBP-class protein binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 8948634]; GO_function: GO:0001132 - TBP-class protein binding RNA polymerase II transcription factor activity [Evidence IPI] [PMID 9096360]; GO_function: GO:0001129 - TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [Evidence IMP] [PMID 18048413]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18703679]; GO_function: GO:0001047 - core promoter binding [Evidence IDA] [PMID 18703679]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IDA] [PMID 8948634]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IGI,IMP] [PMID 10713169]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IDA,IMP] [PMID 9023340]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 18048413]; GO_process: GO:1900446 - negative regulation of tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 9023340]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 10713169]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8948634]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 9023340]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9096360]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8948634]; GO_process: GO:0061408 - positive regulation of transcription from RNA polymerase II promoter in response to heat stress [Evidence IMP] [PMID 18048413]; GO_process: GO:0045898 - regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 21976730]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9852143]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852143]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9755161]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9852143]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,ISS] [PMID 9755161]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08098
Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence TAS] [PMID 11356840]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004584 - dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity [Evidence IMP] [PMID 11356840]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 11356840]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 2005867]
similar to AA sequence:KEGG_Orthology:K00817
Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004400 - histidinol-phosphate transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004400 - histidinol-phosphate transaminase activity [Evidence IMP] [PMID 14190241]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
DNA-directed RNA polymerase II subunit RPB7
similar to AA sequence:KEGG_Orthology:K03015
RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; the Rpb4p/Rpb7p subcomplex regulates cellular lifespan via an mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17056745]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 17875743]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17056745]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA,IMP] [PMID 11087726]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IDA,IMP] [PMID 11087726]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 21074047]; GO_process: GO:0000291 - nuclear-transcribed mRNA catabolic process, exonucleolytic [Evidence IGI] [PMID 17875743]; GO_process: GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP] [PMID 17875743]; GO_process: GO:0045948 - positive regulation of translational initiation [Evidence IMP] [PMID 21074047]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 10082533]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 11087726]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16329
similar to AA sequence:KEGG_Orthology:K16330
hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016872 - intramolecular lyase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14848
Nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP,IPI] [PMID 11728313]
similar to AA sequence:KEGG_Orthology:K13339
AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12808025]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA,IMP] [PMID 12808025]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 15634331]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8241279]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IMP,IPI] [PMID 15634331]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16007078]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16911527]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0016562 - protein import into peroxisome matrix, receptor recycling [Evidence IDA,IGI,IMP] [PMID 16007078]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI] [PMID 17465979]
similar to AA sequence:KEGG_Orthology:K15414
Acidic protein of the mitochondrial matrix; involved in oxidative phosphorylation; related to the human complement receptor gC1q-R; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9305894]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9305894]
similar to AA sequence:KEGG_Orthology:K06659
RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22362748]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 22362748]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 22362748]; GO_process: GO:1900008 - negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging [Evidence IMP] [PMID 22362748]; GO_process: GO:0001185 - termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript [Evidence IDA,IMP] [PMID 22805593]
similar to AA sequence:KEGG_Orthology:K02949
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8070651]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18738
RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15351640]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0010834 - telomere maintenance via telomere shortening [Evidence IGI] [PMID 11739741]
sedoheptulose-7-phosphate:D-glyceraldehyde-3- phosphate transaldolase NQM1
similar to AA sequence:KEGG_Orthology:K00616
similar to AA sequence:KEGG_Orthology:K01465
Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004151 - dihydroorotase activity [Evidence IEA,IEA]; GO_function: GO:0004151 - dihydroorotase activity [Evidence IMP,ISS] [PMID 2897615]; GO_function: GO:0004151 - dihydroorotase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0019856 - pyrimidine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IMP] [PMID 2897615]
Dedicator of cytokinesis protein 4 CRK binding protein
similar to AA sequence:KEGG_Orthology:K00354
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17897954]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 8454584]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
proteasome regulatory particle lid subunit RPN13
similar to AA sequence:KEGG_Orthology:K06691
Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11029046]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 18497817]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11029046]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17499717]
similar to AA sequence:KEGG_Orthology:K17978
Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and motochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11121446]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11121446]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005543 - phospholipid binding [Evidence IEA]; GO_function: GO:0015631 - tubulin binding [Evidence IPI] [PMID 11266443]; GO_process: GO:0032065 - cortical protein anchoring [Evidence IEA]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IMP] [PMID 11121446]; GO_process: GO:0000266 - mitochondrial fission [Evidence IMP] [PMID 17336903]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI] [PMID 17336903]; GO_process: GO:0051646 - mitochondrion localization [Evidence IGI,IMP,IPI] [PMID 23341591]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 11121446]
similar to AA sequence:KEGG_Orthology:K09518
Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA,ISS] [PMID 12514182]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]
similar to AA sequence:KEGG_Orthology:K02327
Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER); GO_component: GO:0043625 - delta DNA polymerase complex [Evidence IBA]; GO_component: GO:0043625 - delta DNA polymerase complex [Evidence TAS] [PMID 9745046]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 15773893]; GO_function: GO:0008296 - 3'-5'-exodeoxyribonuclease activity [Evidence IBA]; GO_function: GO:0008296 - 3'-5'-exodeoxyribonuclease activity [Evidence IMP] [PMID 1648480]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA,IMP] [PMID 1678279]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 18635534]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 1678279]; GO_process: GO:0045004 - DNA replication proofreading [Evidence IBA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA] [PMID 16837458]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IDA] [PMID 17429354]; GO_process: GO:0006287 - base-excision repair, gap-filling [Evidence IBA]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IGI] [PMID 15601866]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006297 - nucleotide-excision repair, DNA gap filling [Evidence IBA]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K11407
Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; GO_component: GO:0000938 - GARP complex [Evidence IPI] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10637310]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12377769]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 10637310]; GO_process: GO:0030029 - actin filament-based process [Evidence IGI] [PMID 9153752]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IDA] [PMID 12686613]; GO_process: GO:0006810 - transport [Evidence IEA]
ERMES complex Ca(2+)-binding regulatory GTPase GEM1
similar to AA sequence:KEGG_Orthology:K07870
Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 21825164]; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 21945531]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 15479738]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 15479738]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 21036903]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0019725 - cellular homeostasis [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 18245340]; GO_process: GO:0055091 - phospholipid homeostasis [Evidence IGI] [PMID 21825164]; GO_process: GO:0010821 - regulation of mitochondrion organization [Evidence IMP] [PMID 21825164]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 21536748]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8816439]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 11134339]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21536748]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8816439]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IGI,IMP] [PMID 18762578]; GO_process: GO:0007569 - cell aging [Evidence IMP] [PMID 10662670]; GO_process: GO:0006342 - chromatin silencing [Evidence IMP] [PMID 10662670]; GO_process: GO:0000078 - cytokinesis after mitosis checkpoint [Evidence IGI] [PMID 20980617]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI,IMP] [PMID 8816439]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI,IMP,IPI] [PMID 15619606]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 21536748]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 18762578]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15445
tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer originates from the TRM10 locus; genetic analysis shows the 18-mer is the translation regulator; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0052905 - tRNA (guanine(9)-N(1))-methyltransferase activity [Evidence IEA]; GO_function: GO:0016423 - tRNA (guanine) methyltransferase activity [Evidence IDA] [PMID 12702816]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 12702816]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03564
Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10681558]; GO_component: GO:0005634 - nucleus [Evidence IDA,ISS] [PMID 2408019]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06693
Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11489916]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IDA,IGI,IMP] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence ISS] [PMID 10419517]
similar to AA sequence:KEGG_Orthology:K03107
Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 7925282]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IPI] [PMID 7925282]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IC] [PMID 7925282]; GO_process: GO:0045047 - protein targeting to ER [Evidence IPI] [PMID 7925282]
similar to AA sequence:KEGG_Orthology:K13288
3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9933355]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IMP] [PMID 10716935]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10716935]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI] [PMID 10716935]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 10716935]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 9933355]
similar to AA sequence:KEGG_Orthology:K10744
similar to AA sequence:KEGG_Orthology:K13344
Integral peroxisomal membrane protein; required for translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8858166]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8858167]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 10087260]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12595255]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IEA]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IGI,IPI] [PMID 10087260]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 12595255]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 15798189]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05857
Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 10779349]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 12756538]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IPI] [PMID 10779349]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IEA,IEA]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IDA] [PMID 15485855]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IMP] [PMID 7753023]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IDA] [PMID 8395015]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IMP] [PMID 9784626]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IMP] [PMID 10390371]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IMP] [PMID 7753023]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IDA] [PMID 8395015]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19205744]; GO_process: GO:0007165 - signal transduction [Evidence IEA,IEA]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IGI,IPI] [PMID 10514491]
similar to AA sequence:KEGG_Orthology:K14797
Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9034325]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16738661]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 12527778]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IMP,IPI] [PMID 12527778]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11493
Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16365162]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1666302]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1865879]; GO_function: GO:0005087 - Ran guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 1865879]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP] [PMID 2548085]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0006810 - transport [Evidence IEA]
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 20936498]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IMP,IPI] [PMID 8187177]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 8187177]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP,IPI] [PMID 8187177]
Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IGI,ISA] [PMID 8636229]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI] [PMID 8662642]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IGI] [PMID 8636229]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 14690591]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 19935684]
similar to AA sequence:KEGG_Orthology:K14822
Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11116400]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IDA] [PMID 11932453]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 11116400]
top hit is XP_002974472.1 originated in Selaginella moellendorffii
alkaline-responsive transcriptional regulator RIM101
translation elongation factor EF-1 alpha
similar to AA sequence:KEGG_Orthology:K03231
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; TEF2-RFP levels increase during replicative aging; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20032305]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence ISS] [PMID 3026912]; GO_function: GO:0019003 - GDP binding [Evidence IDA] [PMID 17925388]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 17925388]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IMP] [PMID 10514524]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 10766739]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 17203074]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]; GO_process: GO:0006414 - translational elongation [Evidence IMP] [PMID 10514524]
forkhead family transcription factor FKH2
similar to AA sequence:KEGG_Orthology:K02872
Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0032440 - 2-alkenal reductase [NAD(P)] activity [Evidence IDA] [PMID 21276778]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 17497241]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 19007762]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IEA]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IDA] [PMID 17497241]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17497241]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20385783]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17616518]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20385783]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IMP] [PMID 17616518]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0000432 - positive regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 17616518]
similar to AA sequence:KEGG_Orthology:K13199
Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15044472]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 15044472]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 15654430]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 15044472]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 15044472]; GO_function: GO:0045142 - triplex DNA binding [Evidence IDA] [PMID 18029617]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 16580682]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IDA] [PMID 11514626]; GO_process: GO:0043558 - regulation of translational initiation in response to stress [Evidence IMP] [PMID 16580682]; GO_process: GO:0000723 - telomere maintenance [Evidence IGI] [PMID 12207228]; GO_process: GO:0006414 - translational elongation [Evidence IGI,IMP] [PMID 19666721]
mitochondrial 37S ribosomal protein MRP51
Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 9528754]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9528754]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 9528754]; GO_process: GO:0070124 - mitochondrial translational initiation [Evidence IGI] [PMID 9528754]
DNA-directed RNA polymerase III core subunit RET1
similar to AA sequence:KEGG_Orthology:K03021
Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0032549 - ribonucleoside binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IGI] [PMID 2199311]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IGI,ISS] [PMID 11454748]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 16735580]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IGI,ISS] [PMID 11454748]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 11454748]
similar to AA sequence:KEGG_Orthology:K00493
N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8183942]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8183942]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01164
Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IPI] [PMID 17881380]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IDA] [PMID 9620854]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 23700311]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000171 - ribonuclease MRP activity [Evidence IMP] [PMID 16618965]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IEA,IEA]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IMP] [PMID 16618965]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034965 - intronic box C/D snoRNA processing [Evidence IDA] [PMID 18713869]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 14729943]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 7926742]; GO_process: GO:0001682 - tRNA 5'-leader removal [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 7926742]
similar to AA sequence:KEGG_Orthology:K11353
dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
similar to AA sequence:KEGG_Orthology:K03846
Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IMP,ISS] [PMID 8692962]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0052926 - dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0052918 - dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004376 - glycolipid mannosyltransferase activity [Evidence IMP] [PMID 15987956]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IMP,ISS] [PMID 8692962]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IMP] [PMID 15987956]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 8692962]
similar to AA sequence:KEGG_Orthology:K01939
Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 8706758]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IDA] [PMID 10417315]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IMP] [PMID 5807803]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IDA] [PMID 8706758]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0044208 - 'de novo' AMP biosynthetic process [Evidence IEA]; GO_process: GO:0006167 - AMP biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5807803]
similar to AA sequence:KEGG_Orthology:K01101
Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004035 - alkaline phosphatase activity [Evidence IDA] [PMID 9561742]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 9561742]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 9561742]
similar to AA sequence:KEGG_Orthology:K01336
Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication; GO_component: GO:0005619 - ascospore wall [Evidence IBA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence TAS] [PMID 2674123]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence TAS] [PMID 9529893]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence ISA] [PMID 3325823]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 377296]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 385314]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 2674123]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IBA,IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 385314]
similar to AA sequence:KEGG_Orthology:K14264
Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17034789]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17034789]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0004061 - arylformamidase activity [Evidence IDA] [PMID 18205391]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016212 - kynurenine-oxoglutarate transaminase activity [Evidence IEA]; GO_function: GO:0016212 - kynurenine-oxoglutarate transaminase activity [Evidence IDA,ISS] [PMID 18205391]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0097053 - L-kynurenine catabolic process [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0034276 - kynurenic acid biosynthetic process [Evidence IDA,ISS] [PMID 18205391]
similar to AA sequence:KEGG_Orthology:K14773
Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16769905]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA,IPI] [PMID 16769905]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0070181 - small ribosomal subunit rRNA binding [Evidence IDA,IMP] [PMID 24152547]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00637
Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10672016]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034736 - cholesterol O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034737 - ergosterol O-acyltransferase activity [Evidence IGI,IMP] [PMID 10672016]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0008204 - ergosterol metabolic process [Evidence IGI,IMP] [PMID 10672016]
similar to AA sequence:KEGG_Orthology:K18156
Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 17135290]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 17135288]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0034982 - mitochondrial protein processing [Evidence IMP] [PMID 17135288]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 17135288]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 17135290]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 18442968]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IDA] [PMID 18442968]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 16415861]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 8553703]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 18442968]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA,IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP] [PMID 18442968]; GO_process: GO:0006412 - translation [Evidence IEA]
JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNAP II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; target of stess-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10523651]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001078 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Evidence IDA,IMP] [PMID 10523651]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IDA,IMP] [PMID 17369256]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IDA,IMP] [PMID 17371840]; GO_function: GO:0032454 - histone demethylase activity (H3-K9 specific) [Evidence IDA] [PMID 17371840]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IMP] [PMID 21296759]; GO_process: GO:0016577 - histone demethylation [Evidence IDA,IMP] [PMID 17369256]; GO_process: GO:0016577 - histone demethylation [Evidence IDA,IMP] [PMID 17371840]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 10523651]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01251
S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004013 - adenosylhomocysteinase activity [Evidence IEA,IEA]; GO_function: GO:0004013 - adenosylhomocysteinase activity [Evidence ISA] [PMID 15556636]; GO_function: GO:0004013 - adenosylhomocysteinase activity [Evidence IMP] [PMID 18591246]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0019510 - S-adenosylhomocysteine catabolic process [Evidence ISA] [PMID 15556636]; GO_process: GO:0019510 - S-adenosylhomocysteine catabolic process [Evidence IMP] [PMID 18591246]; GO_process: GO:0006555 - methionine metabolic process [Evidence NAS] [PMID 11752249]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA,IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 18591246]; GO_process: GO:0006641 - triglyceride metabolic process [Evidence IMP] [PMID 18591246]
similar to AA sequence:KEGG_Orthology:K03686
Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 8168133]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15383543]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 9973563]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 8943361]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 8168133]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 7957078]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 10567545]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 8168133]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9973563]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 8603724]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00456
similar to AA sequence:KEGG_Orthology:K08287
Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 18367543]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IGI] [PMID 18367543]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15634
Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0050278 - sedoheptulose-bisphosphatase activity [Evidence IEA]; GO_function: GO:0050278 - sedoheptulose-bisphosphatase activity [Evidence IDA,IMP] [PMID 21663798]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0046390 - ribose phosphate biosynthetic process [Evidence IDA,IMP] [PMID 21663798]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09553
Hsp90 cochaperone; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12525481]; GO_function: GO:0042030 - ATPase inhibitor activity [Evidence IDA] [PMID 21170051]; GO_function: GO:0030544 - Hsp70 protein binding [Evidence IDA] [PMID 12716905]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 12525481]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 9927435]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_process: GO:0006457 - protein folding [Evidence IGI,IMP] [PMID 8972212]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15103325]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 18769150]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 18769150]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 15155809]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IBA]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IBA]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 15103325]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18769150]; GO_process: GO:0042594 - response to starvation [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K11578
similar to AA sequence:KEGG_Orthology:K12858
RNA helicase in the DEAD-box family; involved in RNA isomerization at the 5' splice site; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence TAS] [PMID 9476892]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence TAS] [PMID 9476892]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000354 - cis assembly of pre-catalytic spliceosome [Evidence TAS] [PMID 9476892]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01209
similar to AA sequence:KEGG_Orthology:K15541
Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 11713271]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IC] [PMID 11713271]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IGI,IMP,IPI] [PMID 11713271]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA,IGI,IMP,IPI] [PMID 11713271]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03248
eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0002188 - translation reinitiation [Evidence IMP] [PMID 20679478]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
inositol monophosphate 1-phosphatase INM2
similar to AA sequence:KEGG_Orthology:K01092
Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008934 - inositol monophosphate 1-phosphatase activity [Evidence IEA]; GO_function: GO:0008934 - inositol monophosphate 1-phosphatase activity [Evidence IDA,ISA] [PMID 10096091]; GO_function: GO:0008934 - inositol monophosphate 1-phosphatase activity [Evidence IGI,IMP] [PMID 12593845]; GO_function: GO:0052832 - inositol monophosphate 3-phosphatase activity [Evidence IEA]; GO_function: GO:0052833 - inositol monophosphate 4-phosphatase activity [Evidence IEA]; GO_function: GO:0052834 - inositol monophosphate phosphatase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006021 - inositol biosynthetic process [Evidence IEA]; GO_process: GO:0046855 - inositol phosphate dephosphorylation [Evidence IDA] [PMID 10096091]; GO_process: GO:0046855 - inositol phosphate dephosphorylation [Evidence IGI,IMP] [PMID 12593845]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00654
Component of serine palmitoyltransferase; responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0017059 - serine C-palmitoyltransferase complex [Evidence IMP] [PMID 1556076]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IMP] [PMID 1556076]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IGI] [PMID 8058731]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 1556076]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K18184
Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10671482]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10671482]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 10671482]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 10671482]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 10671482]
similar to AA sequence:KEGG_Orthology:K00643
5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3023841]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IMP] [PMID 24173275]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IMP] [PMID 323256]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IDA] [PMID 6381051]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IMP] [PMID 7035824]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 323256]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14676
Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15044461]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA,IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IDA] [PMID 15044461]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0034638 - phosphatidylcholine catabolic process [Evidence IMP] [PMID 15044461]; GO_process: GO:0046470 - phosphatidylcholine metabolic process [Evidence IEA]; GO_process: GO:0071071 - regulation of phospholipid biosynthetic process [Evidence IMP] [PMID 19841481]
mitochondrial 54S ribosomal protein YmL4
similar to AA sequence:KEGG_Orthology:K17428
Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 20404317]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 3060376]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 20404317]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 3060376]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 20404317]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7828914]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09648
Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042720 - mitochondrial inner membrane peptidase complex [Evidence IPI] [PMID 8132591]; GO_component: GO:0042720 - mitochondrial inner membrane peptidase complex [Evidence IPI] [PMID 8266095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IDA] [PMID 8132591]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 8266095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IMP] [PMID 8266095]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12589
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
EF-hand superfamily Ca2+modulated protein
Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06185
ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16260602]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042624 - ATPase activity, uncoupled [Evidence IMP] [PMID 16260602]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 16260602]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 16260602]
similar to AA sequence:KEGG_Orthology:K15333
2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016423 - tRNA (guanine) methyltransferase activity [Evidence IDA] [PMID 9917067]; GO_function: GO:0009020 - tRNA (guanosine-2'-O-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 9917067]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
Kinesin-related antiparallel sliding motor protein involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; also inhibits spindle elongation and promotes spindle disassembly in late anaphase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 9693366]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 9693366]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906145]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906148]; GO_function: GO:0070463 - tubulin-dependent ATPase activity [Evidence IDA] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 23851487]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 9813090]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IGI,IMP] [PMID 10525539]; GO_process: GO:0031115 - negative regulation of microtubule polymerization [Evidence IMP] [PMID 24616221]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 9693366]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906145]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906148]; GO_process: GO:0032888 - regulation of mitotic spindle elongation [Evidence IMP] [PMID 24616221]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 23851487]
similar to AA sequence:KEGG_Orthology:K14168
Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18664566]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 19145231]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IEA,IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18664566]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA,IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 17592039]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K14405
Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP] [PMID 11238938]; GO_function: GO:0030674 - protein binding, bridging [Evidence IGI,IMP] [PMID 21282348]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 7736590]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00987
Guanylyltransferase involved in mRNA 5' capping; subunit of the mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5?-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; GO_component: GO:0031533 - mRNA cap methyltransferase complex [Evidence IEA]; GO_component: GO:0031533 - mRNA cap methyltransferase complex [Evidence IGI,IPI] [PMID 9710603]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9832501]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004484 - mRNA guanylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004484 - mRNA guanylyltransferase activity [Evidence IMP] [PMID 8718687]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA,IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IMP] [PMID 8718687]; GO_process: GO:0006397 - mRNA processing [Evidence IEA,IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 15226422]
mitochondrial 37S ribosomal protein RSM23
similar to AA sequence:KEGG_Orthology:K17408
Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
similar to AA sequence:KEGG_Orthology:K08158
Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016298 - lipase activity [Evidence NAS] [PMID 10341423]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10341423]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
mitochondrial 37S ribosomal protein MRPS9
similar to AA sequence:KEGG_Orthology:K02996
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17973
Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly; GO_component: GO:0031416 - NatB complex [Evidence IDA] [PMID 12783868]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IMP] [PMID 12783868]; GO_process: GO:0017196 - N-terminal peptidyl-methionine acetylation [Evidence IGI,IMP] [PMID 12783868]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IMP] [PMID 9105043]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 9105043]
similar to AA sequence:KEGG_Orthology:K14820
Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 11864607]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IPI] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11864607]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 17110339]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10727015]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress; GO_component: GO:0031415 - NatA complex [Evidence IDA] [PMID 14517307]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 14517307]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IDA,IMP] [PMID 2551674]; GO_function: GO:0061607 - peptide alpha-N-propionyltransferase activity [Evidence IMP] [PMID 23043182]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006474 - N-terminal protein amino acid acetylation [Evidence IDA,IMP] [PMID 2551674]; GO_process: GO:0061606 - N-terminal protein amino acid propionylation [Evidence IMP] [PMID 23043182]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 17652096]
similar to AA sequence:KEGG_Orthology:K10686
Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019781 - NEDD8 activating enzyme activity [Evidence IDA,ISS] [PMID 9545234]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008641 - small protein activating enzyme activity [Evidence IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence IDA,IMP,ISS] [PMID 9545234]
tethering complex ATP-binding subunit VPS33
similar to AA sequence:KEGG_Orthology:K12178
similar to AA sequence:KEGG_Orthology:K06062
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IPI] [PMID 10490601]; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IDA] [PMID 7862114]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 18039853]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0010484 - H3 histone acetyltransferase activity [Evidence IDA,IGI,IMP] [PMID 18458063]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 8601308]; GO_function: GO:0070577 - lysine-acetylated histone binding [Evidence IDA] [PMID 20126658]; GO_function: GO:0003713 - transcription coactivator activity [Evidence TAS] [PMID 15075257]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IGI,IMP] [PMID 18458063]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 9042963]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 19822662]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 11867538]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
proteasome core particle subunit alpha 5
similar to AA sequence:KEGG_Orthology:K02729
Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16569
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000928 - gamma-tubulin small complex, spindle pole body [Evidence IPI] [PMID 9384578]; GO_component: GO:0005822 - inner plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005815 - microtubule organizing center [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005824 - outer plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 22842922]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9215630]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence TAS] [PMID 9153752]
similar to AA sequence:KEGG_Orthology:K06662
Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10660302]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 9564050]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 11267834]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10511543]
Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36; GRX3 has a paralog, GRX4, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18281282]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15456753]; GO_component: GO:0005634 - nucleus [Evidence IGI,IPI] [PMID 17074835]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 23045394]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IGI,IMP,ISS] [PMID 10567543]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 20889785]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IPI] [PMID 17074835]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI,IMP] [PMID 10567543]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17074835]; GO_process: GO:2000678 - negative regulation of transcription regulatory region DNA binding [Evidence IMP] [PMID 23045394]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11315
similar to AA sequence:KEGG_Orthology:K17732
Smaller subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0017087 - mitochondrial processing peptidase complex [Evidence IDA] [PMID 2905264]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 2905264]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IDA] [PMID 2007593]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00237
Mitochondrial inner membrane hypothetical protein; similar to Tim18p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; SHH4 has a paralog, SDH4, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10637294]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12180
similar to AA sequence:KEGG_Orthology:K09246
Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3311884]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IDA] [PMID 10688655]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 10688655]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
BAG family molecular chaperone regulator Bag102
similar to AA sequence:KEGG_Orthology:K06902
Vacuolar integral membrane protein required for efflux of amino acids; required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 17021250]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032974 - amino acid transmembrane export from vacuole [Evidence IMP] [PMID 17021250]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23222640]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 10564276]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 10564276]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IPI] [PMID 10564276]
bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase
similar to AA sequence:KEGG_Orthology:K01785
UDP-glucose-4-epimerase; catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 14764091]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IEA,IEA]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IMP] [PMID 14158615]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IEA]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IMP] [PMID 14158615]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IDA] [PMID 14764091]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05012
Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15710404]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 9614122]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0034707 - chloride channel complex [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17662057]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15710404]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17662057]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17662057]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0005254 - chloride channel activity [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IDA] [PMID 12074596]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9614122]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:1902476 - chloride transmembrane transport [Evidence IEA]; GO_process: GO:0006821 - chloride transport [Evidence IEA,IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0044070 - regulation of anion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03131
Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9844639]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0051090 - regulation of sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12811
RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 8969184]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000348 - mRNA branch site recognition [Evidence TAS] [PMID 9476892]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
putative tyrosine protein phosphatase SIW14
similar to AA sequence:KEGG_Orthology:K18045
similar to AA sequence:KEGG_Orthology:K02213
Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 10075735]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 8083240]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 8083240]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 8083240]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8083240]; GO_function: GO:0003682 - chromatin binding [Evidence IMP] [PMID 10075735]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10075735]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9312054]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10075735]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 10075735]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 8538771]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 9335335]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 9990508]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16980387]
ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 11007476]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19061897]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070417 - cellular response to cold [Evidence IMP] [PMID 11855848]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 11063674]; GO_process: GO:0048255 - mRNA stabilization [Evidence IMP] [PMID 15220333]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11557770]; GO_process: GO:0061399 - positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion [Evidence IMP] [PMID 11509659]; GO_process: GO:0061419 - positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [Evidence IMP] [PMID 11509659]; GO_process: GO:0036083 - positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9927444]
ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 11007476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11007476]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_process: GO:0070417 - cellular response to cold [Evidence IGI] [PMID 11855848]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 11063674]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11557770]; GO_process: GO:0036083 - positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9927444]
similar to AA sequence:KEGG_Orthology:K05349
similar to AA sequence:KEGG_Orthology:K10968
Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 10521541]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000033 - alpha-1,3-mannosyltransferase activity [Evidence IGI,IMP] [PMID 10521541]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IGI,IMP] [PMID 10521541]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K02898
Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11360
GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 12189143]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI,ISS] [PMID 12189143]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 12189143]
cyclin-dependent protein kinase-activating kinase CAK1
similar to AA sequence:KEGG_Orthology:K07760
similar to AA sequence:KEGG_Orthology:K15903
similar to AA sequence:KEGG_Orthology:K00850
Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2,6-bisphosphate and AMP; mutation inhibits glucose induction of cell cycle-related genes; GO_component: GO:0005945 - 6-phosphofructokinase complex [Evidence IEA]; GO_component: GO:0005945 - 6-phosphofructokinase complex [Evidence IMP] [PMID 3007939]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_function: GO:0003872 - 6-phosphofructokinase activity [Evidence IEA,IEA]; GO_function: GO:0003872 - 6-phosphofructokinase activity [Evidence IMP] [PMID 3007939]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0006002 - fructose 6-phosphate metabolic process [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 3000145]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 3007939]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IGI] [PMID 18632794]
similar to AA sequence:KEGG_Orthology:K01581
Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004586 - ornithine decarboxylase activity [Evidence IEA]; GO_function: GO:0004586 - ornithine decarboxylase activity [Evidence IDA] [PMID 2681188]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009446 - putrescine biosynthetic process [Evidence IMP] [PMID 7929015]; GO_process: GO:0033387 - putrescine biosynthetic process from ornithine [Evidence IEA]
aromatic ring-opening dioxygenase (predicted)
similar to AA sequence:KEGG_Orthology:K01130
biotin--[acetyl-CoA-carboxylase] ligase BPL1
similar to AA sequence:KEGG_Orthology:K01942
Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004077 - biotin-[acetyl-CoA-carboxylase] ligase activity [Evidence IEA,IEA]; GO_function: GO:0004077 - biotin-[acetyl-CoA-carboxylase] ligase activity [Evidence IMP] [PMID 6108218]; GO_function: GO:0004078 - biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity [Evidence IEA]; GO_function: GO:0004079 - biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity [Evidence IEA]; GO_function: GO:0004080 - biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity [Evidence IEA]; GO_function: GO:0071734 - biotin-[pyruvate-carboxylase] ligase activity [Evidence IDA] [PMID 10551847]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009305 - protein biotinylation [Evidence IDA] [PMID 10551847]; GO_process: GO:0009305 - protein biotinylation [Evidence IMP] [PMID 6108218]
similar to AA sequence:KEGG_Orthology:K06677
Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11854418]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IGI] [PMID 11864994]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 11854418]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA,IEA]; GO_process: GO:0043007 - maintenance of rDNA [Evidence IMP] [PMID 17203076]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IMP] [PMID 14662740]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IMP] [PMID 14662740]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IPI] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11854418]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11864994]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 11854418]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 11864994]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 14662740]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16738307]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16738307]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 16738307]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IGI] [PMID 16738307]; GO_process: GO:0022618 - ribonucleoprotein complex assembly [Evidence IMP] [PMID 16738307]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IGI] [PMID 9707445]
similar to AA sequence:KEGG_Orthology:K11684
mitochondrial 54S ribosomal protein YmL6
similar to AA sequence:KEGG_Orthology:K02926
Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15713625]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15632184]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004771 - sterol esterase activity [Evidence IEA]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA,IMP] [PMID 15632184]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA] [PMID 15713625]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 14587103]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 15632184]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 15713625]
similar to AA sequence:KEGG_Orthology:K00860
Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004020 - adenylylsulfate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004020 - adenylylsulfate kinase activity [Evidence IMP] [PMID 197388]; GO_function: GO:0004020 - adenylylsulfate kinase activity [Evidence IDA] [PMID 3019265]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IMP] [PMID 197388]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
similar to AA sequence:KEGG_Orthology:K12191
Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12194857]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IPI] [PMID 12194857]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
similar to AA sequence:KEGG_Orthology:K03083
Vacuolar membrane hypothetical protein; involved in vacuolar protein sorting; also detected in the mitochondria; GO_component: GO:0034424 - Vps55/Vps68 complex [Evidence IDA,IPI] [PMID 18216282]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 18216282]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15030
similar to AA sequence:KEGG_Orthology:K02925
Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 3537704]; GO_process: GO:0006412 - translation [Evidence IEA]
Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10757808]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10757808]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA,IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IGI,IMP] [PMID 18694928]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IDA] [PMID 23919454]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006037 - cell wall chitin metabolic process [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0071555 - cell wall organization [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
similar to AA sequence:KEGG_Orthology:K13507
Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 19525420]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004366 - glycerol-3-phosphate O-acyltransferase activity [Evidence IEA]; GO_function: GO:0004366 - glycerol-3-phosphate O-acyltransferase activity [Evidence IDA,IGI,IMP] [PMID 11544256]; GO_function: GO:0016287 - glycerone-phosphate O-acyltransferase activity [Evidence IEA]; GO_function: GO:0016287 - glycerone-phosphate O-acyltransferase activity [Evidence IDA] [PMID 11544256]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IGI,IMP] [PMID 11544256]
Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine; GO_component: GO:0005634 - nucleus [Evidence ISA] [PMID 10392447]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence ISA] [PMID 10392447]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence ISA] [PMID 10392447]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]
Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10373505]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10373505]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IGI,IPI] [PMID 12618390]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 10373505]; GO_process: GO:0071590 - nicotinamide riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0071592 - nicotinic acid riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP,IPI] [PMID 7667094]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 9725828]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 10373505]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18655
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 19198597]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10610322]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15280434]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9564048]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IPI] [PMID 10428971]; GO_component: GO:0044614 - nuclear pore cytoplasmic filaments [Evidence IDA] [PMID 10610322]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15280434]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 17272721]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence IDA,ISS] [PMID 9564047]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 19805289]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000822 - inositol hexakisphosphate binding [Evidence IDA] [PMID 16783363]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI,IMP] [PMID 9564048]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IGI,IPI] [PMID 17272721]; GO_process: GO:0006810 - transport [Evidence IEA]
phenylalanine--tRNA ligase subunit alpha
similar to AA sequence:KEGG_Orthology:K01889
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0009328 - phenylalanine-tRNA ligase complex [Evidence IDA] [PMID 3049607]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 16162501]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 166841]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 16162501]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 166841]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
guanine nucleotide-binding protein subunit alpha
similar to AA sequence:KEGG_Orthology:K04640
Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16839886]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IBA]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA,IPI] [PMID 11394869]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8756677]; GO_function: GO:0031683 - G-protein beta/gamma-subunit complex binding [Evidence IBA,IEA]; GO_function: GO:0001664 - G-protein coupled receptor binding [Evidence IBA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11394869]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 1900495]; GO_function: GO:0019001 - guanyl nucleotide binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IBA,IEA,IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 12556475]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 2105453]; GO_process: GO:0007189 - adenylate cyclase-activating G-protein coupled receptor signaling pathway [Evidence IBA,IEA]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IMP] [PMID 16839886]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 3113739]; GO_process: GO:0071701 - regulation of MAPK export from nucleus [Evidence IMP] [PMID 12556475]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K04705
Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes; GO_component: GO:0033565 - ESCRT-0 complex [Evidence IPI] [PMID 12055639]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12055639]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12055639]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 20150893]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12055639]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12055639]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04709
Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enahnces invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication; GO_component: GO:0061576 - acyl-CoA ceramide synthase complex [Evidence IDA] [PMID 15692566]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11387200]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11694577]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IDA] [PMID 15692566]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 11694577]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IDA] [PMID 15692566]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IEP,IMP] [PMID 8195187]
mitochondrial 37S ribosomal protein MRP4
similar to AA sequence:KEGG_Orthology:K02967
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0000049 - tRNA binding [Evidence ISS] [PMID 9445368]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
mitogen-activated protein kinase kinase kinase kinase STE20
similar to AA sequence:KEGG_Orthology:K04409
Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 14704159]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 24003114]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 14704159]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K17262
Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0043014 - alpha-tubulin binding [Evidence IPI] [PMID 9885248]; GO_function: GO:0008017 - microtubule binding [Evidence IPI] [PMID 9885248]; GO_process: GO:0007023 - post-chaperonin tubulin folding pathway [Evidence IMP,IPI] [PMID 9885248]; GO_process: GO:0006457 - protein folding [Evidence IMP,IPI] [PMID 9885248]
similar to AA sequence:KEGG_Orthology:K11497
Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA] [PMID 9407032]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0000818 - nuclear MIS12/MIND complex [Evidence IDA] [PMID 14581449]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IEA]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 9407032]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 22561346]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8408221]; GO_process: GO:0051382 - kinetochore assembly [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 8408221]
Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8183917]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8583924]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9202009]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9202009]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IMP] [PMID 12972569]; GO_function: GO:0004663 - Rab geranylgeranyltransferase activity [Evidence IDA,IMP] [PMID 8183917]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8132658]; GO_process: GO:0032858 - activation of Rab GTPase activity [Evidence IMP] [PMID 7750142]; GO_process: GO:0032858 - activation of Rab GTPase activity [Evidence IMP] [PMID 8132658]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IMP] [PMID 12972569]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 8183917]
Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 17176761]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19254924]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15950597]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9802016]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence ISS] [PMID 8654575]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence IMP] [PMID 9802016]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IDA] [PMID 15950597]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030004 - cellular monovalent inorganic cation homeostasis [Evidence IMP] [PMID 9802016]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IMP] [PMID 16402204]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 16402204]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02900
Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence TAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 2104804]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence TAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence TAS] [PMID 9559554]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]; GO_process: GO:0046898 - response to cycloheximide [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07023
similar to AA sequence:KEGG_Orthology:K14568
Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11694595]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 11935223]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11694595]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11935223]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0070037 - rRNA (pseudouridine) methyltransferase activity [Evidence IMP,ISO] [PMID 20972225]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0070475 - rRNA base methylation [Evidence IMP,ISO] [PMID 20972225]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11694595]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 11694595]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI] [PMID 16721597]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01526
Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence TAS] [PMID 11425802]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004382 - guanosine-diphosphatase activity [Evidence IEA]; GO_function: GO:0004382 - guanosine-diphosphatase activity [Evidence IDA] [PMID 7506254]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0045134 - uridine-diphosphatase activity [Evidence IDA] [PMID 11425802]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence TAS] [PMID 11713596]
Transcription factor required for response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA,IGI,IMP] [PMID 17101777]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 8754797]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 8754797]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IEP] [PMID 17101777]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0007329 - positive regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IDA,IEP,IGI,IMP] [PMID 17101777]
putative DEAD-box ATP-dependent RNA helicase DBP1
similar to AA sequence:KEGG_Orthology:K11594
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 1857205]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 8144024]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 14763975]
similar to AA sequence:KEGG_Orthology:K12488
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 21135091]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 21135091]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA] [PMID 12627398]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IGI,ISS] [PMID 9677411]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 21135091]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01681
Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15975908]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15692048]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence IDA,IMP] [PMID 1972545]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 17698960]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 17698960]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 15692048]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IDA] [PMID 1972545]
similar to AA sequence:KEGG_Orthology:K01052
Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15713625]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 15713625]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016298 - lipase activity [Evidence ISS] [PMID 1574929]; GO_function: GO:0004771 - sterol esterase activity [Evidence IEA]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA] [PMID 15713625]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10515935]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 15713625]
Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; GUP1 has a paralog, GUP2, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15813700]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA,ISS] [PMID 10931309]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15813700]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IMP] [PMID 16597698]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IMP] [PMID 18036137]; GO_function: GO:0015293 - symporter activity [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 16597698]; GO_process: GO:0019563 - glycerol catabolic process [Evidence IGI,IMP] [PMID 10747858]; GO_process: GO:0015793 - glycerol transport [Evidence IGI,IMP] [PMID 10931309]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
hypothetical protein; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 16565073]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 11401825]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11401825]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12447444]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015301 - anion:anion antiporter activity [Evidence IEA]; GO_function: GO:0080139 - borate efflux transmembrane transporter activity [Evidence IMP,ISA] [PMID 12447444]; GO_function: GO:0080139 - borate efflux transmembrane transporter activity [Evidence IMP] [PMID 16923078]; GO_function: GO:0080139 - borate efflux transmembrane transporter activity [Evidence IDA,IMP] [PMID 17459946]; GO_function: GO:0005452 - inorganic anion exchanger activity [Evidence IEA]; GO_process: GO:0006820 - anion transport [Evidence IEA]; GO_process: GO:0046713 - borate transport [Evidence IMP,ISA] [PMID 12447444]; GO_process: GO:0046713 - borate transport [Evidence IMP] [PMID 16923078]; GO_process: GO:0046713 - borate transport [Evidence IDA,IMP] [PMID 17459946]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 16565073]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06679
similar to AA sequence:KEGG_Orthology:K10704
Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10880451]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10880451]; GO_component: GO:0031371 - ubiquitin conjugating enzyme complex [Evidence IPI] [PMID 10089880]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,ISS] [PMID 10089880]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISS] [PMID 9576943]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IDA] [PMID 19706603]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IMP] [PMID 10089880]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IMP] [PMID 9576943]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA,IPI] [PMID 10089880]
similar to AA sequence:KEGG_Orthology:K14299
Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IC] [PMID 11823431]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 10684247]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14841
Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
hypothetical protein; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12628920]; GO_process: GO:0008150 - biological_process [Evidence ND]
Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase (HDAC) complexes; APCC(Cdh1) substrate; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12464632]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 12760057]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 22333912]
similar to AA sequence:KEGG_Orthology:K00981
Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; GO_component: GO:0070319 - Golgi to plasma membrane transport vesicle [Evidence IDA] [PMID 2163397]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23623749]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8557688]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004605 - phosphatidate cytidylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004605 - phosphatidate cytidylyltransferase activity [Evidence IDA] [PMID 8557688]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IMP] [PMID 2832385]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IMP] [PMID 2832385]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IMP] [PMID 8557688]; GO_process: GO:0006658 - phosphatidylserine metabolic process [Evidence IMP] [PMID 2832385]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24759102]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24759102]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 22204397]; GO_function: GO:0000309 - nicotinamide-nucleotide adenylyltransferase activity [Evidence IDA,IGI] [PMID 24759102]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 22204397]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 24759102]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI] [PMID 21460040]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 21460040]
GPI-anchored hypothetical protein; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12583915]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 15583168]
similar to AA sequence:KEGG_Orthology:K02981
Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 2517480]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 3533916]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 385049]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0070181 - small ribosomal subunit rRNA binding [Evidence IDA] [PMID 2517480]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 2517480]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IMP] [PMID 17545469]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IMP] [PMID 3522920]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
peptidylprolyl isomerase family protein FPR2
similar to AA sequence:KEGG_Orthology:K09569
Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence ISS] [PMID 7685904]; GO_component: GO:0016020 - membrane [Evidence IBA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005528 - FK506 binding [Evidence IDA] [PMID 1380159]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IBA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence ISS] [PMID 7685904]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0018208 - peptidyl-proline modification [Evidence IBA]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA]
Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090; GO_component: GO:0072546 - ER membrane protein complex [Evidence IEA]; GO_component: GO:0072546 - ER membrane protein complex [Evidence IDA] [PMID 19325107]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP); GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 12631707]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0070390 - transcription export complex 2 [Evidence IDA] [PMID 15311284]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12411502]; GO_process: GO:0030029 - actin filament-based process [Evidence IGI] [PMID 2656401]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 12411502]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI,IMP,IPI] [PMID 12631707]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IMP] [PMID 8799844]; GO_process: GO:0071033 - nuclear retention of pre-mRNA at the site of transcription [Evidence IMP] [PMID 18003937]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 18003937]; GO_process: GO:0006611 - protein export from nucleus [Evidence IGI,IMP] [PMID 10716708]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06269
Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; PPZ1 has a paralog, PPZ2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 16166647]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8824289]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004724 - magnesium-dependent protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 7615085]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 21237705]; GO_process: GO:0006883 - cellular sodium ion homeostasis [Evidence IGI,IMP] [PMID 7768897]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 21237705]
similar to AA sequence:KEGG_Orthology:K03258
similar to AA sequence:KEGG_Orthology:K02912
Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12807768]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,ISS] [PMID 10559187]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 15574876]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]
Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 17095012]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 19703468]
similar to AA sequence:KEGG_Orthology:K07975
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 10207081]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10207081]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 10207081]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 10526184]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 10588647]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 8852836]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IMP] [PMID 10588647]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI,IPI] [PMID 19955214]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI] [PMID 8852836]; GO_process: GO:0090338 - positive regulation of formin-nucleated actin cable assembly [Evidence IGI,IMP] [PMID 12810699]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15040
similar to AA sequence:KEGG_Orthology:K12193
One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9606181]; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 9606181]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
RNA polymerase II transcription elongation factor SpEAF
similar to AA sequence:KEGG_Orthology:K00974
ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 1634528]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 8175766]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 8617732]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 1634528]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence NAS] [PMID 1634528]; GO_component: GO:0005634 - nucleus [Evidence NAS] [PMID 8175766]; GO_component: GO:0005634 - nucleus [Evidence NAS] [PMID 8617732]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0052929 - ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [Evidence IEA]; GO_function: GO:0052928 - CTP:3'-cytidine-tRNA cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0052927 - CTP:tRNA cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004810 - tRNA adenylyltransferase activity [Evidence IDA] [PMID 1634528]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0001680 - tRNA 3'-terminal CCA addition [Evidence IEA]; GO_process: GO:0001680 - tRNA 3'-terminal CCA addition [Evidence IDA] [PMID 1634528]
similar to AA sequence:KEGG_Orthology:K08737
Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p; GO_component: GO:0032301 - MutSalpha complex [Evidence IPI] [PMID 8816473]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000228 - nuclear chromosome [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 9545323]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9819445]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 10066781]; GO_function: GO:0032137 - guanine/thymine mispair binding [Evidence IDA] [PMID 8816473]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IMP] [PMID 10347163]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IDA] [PMID 8816473]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IBA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IDA] [PMID 11237611]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 2685551]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9520271]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IBA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IBA]; GO_process: GO:0009411 - response to UV [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K00939
Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15753074]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8537371]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8537371]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0019205 - nucleobase-containing compound kinase activity [Evidence IEA]; GO_function: GO:0046899 - nucleoside triphosphate adenylate kinase activity [Evidence IEA]; GO_function: GO:0046899 - nucleoside triphosphate adenylate kinase activity [Evidence IDA] [PMID 15753074]; GO_function: GO:0046899 - nucleoside triphosphate adenylate kinase activity [Evidence IDA] [PMID 8537371]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016776 - phosphotransferase activity, phosphate group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IDA] [PMID 15753074]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07034
Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17395151]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IMP] [PMID 12429834]; GO_process: GO:0015696 - ammonium transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEP,IMP] [PMID 12429834]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 12429834]; GO_process: GO:0006810 - transport [Evidence IEA]
Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 2642897]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0001002 - RNA polymerase III type 1 promoter sequence-specific DNA binding [Evidence IDA] [PMID 2642897]; GO_function: GO:0001152 - RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity [Evidence IDA,IMP] [PMID 8496187]; GO_function: GO:0001156 - TFIIIC-class transcription factor binding [Evidence IC] [PMID 8496187]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0042791 - 5S class rRNA transcription from RNA polymerase III type 1 promoter [Evidence IDA] [PMID 2642897]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
top hit is XP_007271903.1 originated in Fomitiporia mediterranea MF3/22
similar to AA sequence:KEGG_Orthology:K00428
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IEA]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IMP] [PMID 10589830]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA] [PMID 17580971]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA,IMP] [PMID 21334283]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10589830]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17806
Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 16107694]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 16107694]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
similar to AA sequence:KEGG_Orthology:K00006
NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 10781551]; GO_component: GO:0009331 - glycerol-3-phosphate dehydrogenase complex [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0004367 - glycerol-3-phosphate dehydrogenase [NAD+] activity [Evidence IEA,IEA]; GO_function: GO:0004367 - glycerol-3-phosphate dehydrogenase [NAD+] activity [Evidence IMP] [PMID 9171333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IMP] [PMID 9171333]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IMP] [PMID 9171333]; GO_process: GO:0046168 - glycerol-3-phosphate catabolic process [Evidence IEA]; GO_process: GO:0006072 - glycerol-3-phosphate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K10669
tRNA 2'-phosphotransferase; catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22391451]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22391451]; GO_function: GO:0000215 - tRNA 2'-phosphotransferase activity [Evidence IEA]; GO_function: GO:0000215 - tRNA 2'-phosphotransferase activity [Evidence IDA] [PMID 9148937]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IDA] [PMID 9148937]
RSC chromatin remodeling complex ATPase subunit STH1
ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 8980231]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1396591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1549132]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 9799253]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0070577 - lysine-acetylated histone binding [Evidence IDA] [PMID 20126658]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 10025404]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8980231]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 9799253]; GO_process: GO:0006284 - base-excision repair [Evidence IMP] [PMID 24674626]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0031055 - chromatin remodeling at centromere [Evidence IMP] [PMID 12697820]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 12697820]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IGI,IMP] [PMID 12072455]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16024655]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 10320476]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0016584 - nucleosome positioning [Evidence IMP] [PMID 21343911]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 10320476]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 10329629]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
Arf family guanine nucleotide exchange factor SYT1
hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K18046
Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00111
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner; GO_component: GO:0009331 - glycerol-3-phosphate dehydrogenase complex [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 8256521]; GO_function: GO:0004368 - glycerol-3-phosphate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004368 - glycerol-3-phosphate dehydrogenase activity [Evidence IDA] [PMID 12032156]; GO_function: GO:0004368 - glycerol-3-phosphate dehydrogenase activity [Evidence IMP,ISS] [PMID 8256521]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0052590 - sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity [Evidence IEA]; GO_function: GO:0052591 - sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0019563 - glycerol catabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IMP] [PMID 8256521]; GO_process: GO:0006072 - glycerol-3-phosphate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 18381895]
Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9705508]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 16215179]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0001046 - core promoter sequence-specific DNA binding [Evidence IDA] [PMID 1495962]; GO_function: GO:0001046 - core promoter sequence-specific DNA binding [Evidence IDA] [PMID 2683089]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 1495962]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 1495962]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 3303332]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004059 - aralkylamine N-acetyltransferase activity [Evidence IDA] [PMID 11559708]; GO_function: GO:0004145 - diamine N-acetyltransferase activity [Evidence IDA,IMP] [PMID 15723835]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 15723835]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K11885
DNA damage-inducible v-SNARE binding protein; role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10330187]; GO_function: GO:0000149 - SNARE binding [Evidence IDA] [PMID 10330187]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence ISA] [PMID 11516960]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 11323716]; GO_process: GO:0009306 - protein secretion [Evidence IMP] [PMID 21094643]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12051757]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IMP] [PMID 10330187]
similar to AA sequence:KEGG_Orthology:K09248
Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1986247]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 1986247]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 8846888]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 8846888]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:2001158 - positive regulation of proline catabolic process to glutamate [Evidence IMP] [PMID 2689862]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2689862]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8846888]; GO_process: GO:0006560 - proline metabolic process [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 22579222]
Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15208443]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15208443]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15208443]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14861
similar to AA sequence:KEGG_Orthology:K14785
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 15964808]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15964808]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15964808]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 16772403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16772403]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15964808]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15964808]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15964808]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0034462 - small-subunit processome assembly [Evidence IMP] [PMID 15964808]
similar to AA sequence:KEGG_Orthology:K11718
Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence TAS] [PMID 10601196]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_function: GO:0003980 - UDP-glucose:glycoprotein glucosyltransferase activity [Evidence IEA]; GO_function: GO:0003980 - UDP-glucose:glycoprotein glucosyltransferase activity [Evidence IDA] [PMID 9611196]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence TAS] [PMID 8550469]; GO_process: GO:0097359 - UDP-glucosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs; GO_component: GO:0045025 - mitochondrial degradosome [Evidence IDA] [PMID 12426313]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IEA]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IDA] [PMID 12426313]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IDA] [PMID 17658549]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0090503 - RNA phosphodiester bond hydrolysis, exonucleolytic [Evidence IEA]; GO_process: GO:0000957 - mitochondrial RNA catabolic process [Evidence IMP] [PMID 12426313]; GO_process: GO:0000957 - mitochondrial RNA catabolic process [Evidence IMP] [PMID 9829834]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01507
Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IDA] [PMID 8224193]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IC] [PMID 8224193]
similar to AA sequence:KEGG_Orthology:K01783
D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 11298766]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016857 - racemase and epimerase activity, acting on carbohydrates and derivatives [Evidence IEA]; GO_function: GO:0004750 - ribulose-phosphate 3-epimerase activity [Evidence IEA,IEA]; GO_function: GO:0004750 - ribulose-phosphate 3-epimerase activity [Evidence IDA,IMP,ISS] [PMID 8929392]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA,IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 8929392]
similar to AA sequence:KEGG_Orthology:K17981
similar to AA sequence:KEGG_Orthology:K15110
Mitochondrial inner membrane transporter; exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11013234]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9178508]; GO_function: GO:0005310 - dicarboxylic acid transmembrane transporter activity [Evidence IDA] [PMID 11013234]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006839 - mitochondrial transport [Evidence IDA] [PMID 11013234]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IEA,IEA]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IPI] [PMID 10693764]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IDA,IMP] [PMID 17114583]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 12050116]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IMP,ISS] [PMID 10693764]; GO_function: GO:0051880 - G-quadruplex DNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IGI,IMP,IPI] [PMID 10693764]; GO_process: GO:0044806 - G-quadruplex DNA unwinding [Evidence IMP] [PMID 23657261]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 15907372]; GO_process: GO:0097046 - replication fork progression beyond termination site [Evidence IMP] [PMID 20797631]; GO_process: GO:0000723 - telomere maintenance [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00030
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; GO_component: GO:0005962 - mitochondrial isocitrate dehydrogenase complex (NAD+) [Evidence IDA] [PMID 16884682]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8626605]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 16884682]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IDA] [PMID 16884682]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
similar to AA sequence:KEGG_Orthology:K14788
Essential nucleolar protein; required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IPI] [PMID 14690591]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06123
Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in the mobilization of non-polar lipids; found in lipid particles, the endoplasmic reticulum and the mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones; oleic acid inducible; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10617610]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10617610]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IEA]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IMP] [PMID 10617610]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IGI,IMP] [PMID 24187129]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IMP] [PMID 10617610]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI] [PMID 24187129]
similar to AA sequence:KEGG_Orthology:K14775
Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11500370]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IDA,IPI] [PMID 11500370]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 11500370]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IDA,IMP,IPI] [PMID 11500370]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 17875938]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 17875938]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 17875938]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071466 - cellular response to xenobiotic stimulus [Evidence IMP] [PMID 11943786]; GO_process: GO:0061415 - negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source [Evidence IMP] [PMID 17875938]; GO_process: GO:0035948 - positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17875938]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11943786]; GO_process: GO:0061414 - positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source [Evidence IMP] [PMID 17875938]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02258
Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 2167832]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10501934]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15776235]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IDA] [PMID 15776235]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 12063264]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 10617659]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 2167832]
similar to AA sequence:KEGG_Orthology:K14812
Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 12358428]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IMP,ISS] [PMID 12358428]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12358428]
Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10385521]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10385521]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 10385521]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 10385521]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12456659]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP,IPI] [PMID 15888545]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative paralog of ATR1; but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10967
Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8631921]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IDA] [PMID 9020857]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9182588]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12188
Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression; GO_component: GO:0000814 - ESCRT II complex [Evidence IDA] [PMID 12194858]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000433 - negative regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 7785322]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12194858]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
similar to AA sequence:KEGG_Orthology:K10416
anaphase promoting complex subunit CDC16
similar to AA sequence:KEGG_Orthology:K03353
Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 8895471]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0032297 - negative regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 9660930]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP] [PMID 16481473]
similar to AA sequence:KEGG_Orthology:K14570
3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10359084]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IMP] [PMID 10716935]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI] [PMID 10716935]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 10716935]; GO_process: GO:0002107 - generation of mature 3'-end of 5S rRNA generated by RNA polymerase III [Evidence IMP] [PMID 10716935]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0034415 - tRNA 3'-trailer cleavage, exonucleolytic [Evidence IMP] [PMID 10716935]; GO_process: GO:0034415 - tRNA 3'-trailer cleavage, exonucleolytic [Evidence IGI,IMP] [PMID 18456844]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
saccharopine dehydrogenase (NAD+, L-lysine-forming)
similar to AA sequence:KEGG_Orthology:K00290
Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004754 - saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004754 - saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [Evidence IDA] [PMID 17002315]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IMP] [PMID 17247984]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence NAS] [PMID 11752249]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence TAS] [PMID 3928261]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09827
3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11279045]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12119386]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0000253 - 3-keto sterol reductase activity [Evidence IEA]; GO_function: GO:0000253 - 3-keto sterol reductase activity [Evidence IMP] [PMID 10535978]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 10535978]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]
Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 8264579]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0042937 - tripeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_process: GO:0042938 - dipeptide transport [Evidence IDA] [PMID 16096264]; GO_process: GO:0006857 - oligopeptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IMP] [PMID 8264579]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IDA] [PMID 16096264]
similar to AA sequence:KEGG_Orthology:K17275
Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3060468]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 3060468]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 2643162]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 3060468]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 12857851]; GO_process: GO:0007015 - actin filament organization [Evidence IMP,IPI] [PMID 8522605]
mini-chromosome maintenance complex protein 7
similar to AA sequence:KEGG_Orthology:K02210
Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0097373 - MCM core complex [Evidence IDA] [PMID 13679365]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7708676]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7708676]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 12480933]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15723534]; GO_function: GO:1990163 - ATP-dependent four-way junction helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 15723534]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 2044962]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 13679365]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 15723534]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 19064704]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 19064704]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 2044962]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
similar to AA sequence:KEGG_Orthology:K13025
Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; GO_component: GO:0097078 - FAl1-SGD1 complex [Evidence IPI] [PMID 21576267]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9372960]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISA] [PMID 9372960]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00876
hypothetical protein; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004849 - uridine kinase activity [Evidence IEA]; GO_process: GO:0044211 - CTP salvage [Evidence IEA]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13122
nitrogen permease regulating protein NPR2
similar to AA sequence:KEGG_Orthology:K04077
Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 8097278]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 7902576]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9256426]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 10869431]; GO_function: GO:0051087 - chaperone binding [Evidence IPI] [PMID 9256426]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 10869431]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 1359644]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 1978929]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IMP] [PMID 2645524]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 1347713]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 8097278]; GO_process: GO:0042026 - protein refolding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 1359644]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9256426]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 1359644]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA,IPI] [PMID 11081628]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA,IPI] [PMID 11090616]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24390141]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IGI,ISS] [PMID 11000274]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11081628]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 21357739]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI,IPI] [PMID 11090616]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11081628]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00605
T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005960 - glycine cleavage complex [Evidence ISS] [PMID 9047339]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004047 - aminomethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IMP] [PMID 9047339]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IC] [PMID 9047339]; GO_process: GO:0006544 - glycine metabolic process [Evidence IMP] [PMID 9047339]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI,IMP] [PMID 10871621]
similar to AA sequence:KEGG_Orthology:K02136
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IDA] [PMID 17082766]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IMP] [PMID 7929329]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA,IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 7929329]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 7929329]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence ISS] [PMID 9259571]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence ISS] [PMID 9259571]
Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15649438]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 15649438]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 21148207]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IGI] [PMID 23966878]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 15649438]; GO_process: GO:0010509 - polyamine homeostasis [Evidence IMP] [PMID 21148207]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Ubiquitin-protein ligase; functions in ER retention of misfolded proteins; required for ER-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11139575]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9437001]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11139575]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IGI,IMP] [PMID 11146622]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 11146622]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22298424]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22298424]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 18971375]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 24292014]
phosphomethylpyrimidine kinase (predicted)
similar to AA sequence:KEGG_Orthology:K03676
Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog, GRX1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11958675]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11958675]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IMP,ISS] [PMID 9571241]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 12684511]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 18992757]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IDA] [PMID 12684511]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 9571241]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00457
Fungal Genetics Stock Center 12068; Fungal Genetics Stock Center 12069
hypothetical protein; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
mitochondrial 37S ribosomal protein RSM26
similar to AA sequence:KEGG_Orthology:K04564
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12189
Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; GO_component: GO:0000814 - ESCRT II complex [Evidence IDA] [PMID 12194858]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA,IMP] [PMID 15329733]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA,IMP] [PMID 15469844]; GO_process: GO:0000433 - negative regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 11278625]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12194858]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
similar to AA sequence:KEGG_Orthology:K17600
Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; GO_component: GO:0000938 - GARP complex [Evidence IPI] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10637310]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 10637310]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 17645731]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IDA] [PMID 12686613]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13181
Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISA] [PMID 1454790]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 1454790]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 1454790]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14787
Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 23193268]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11884397]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IDA] [PMID 23193268]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11884397]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11884397]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11884397]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0034462 - small-subunit processome assembly [Evidence IMP] [PMID 18586827]
similar to AA sequence:KEGG_Orthology:K14552
U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030869 - RENT complex [Evidence IPI] [PMID 10219244]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Karyopherin responsible for the nuclear import of Rfp1p; Rfp1p is a ribosome maturation factor; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16581791]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA,IMP] [PMID 20219973]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI] [PMID 16581791]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP,IPI] [PMID 20219973]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01104
similar to AA sequence:KEGG_Orthology:K01166
Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19332891]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 11158587]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 24102742]; GO_component: GO:0005775 - vacuolar lumen [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IDA] [PMID 19332891]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 11158587]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IMP] [PMID 19332891]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0033897 - ribonuclease T2 activity [Evidence IEA,IEA]; GO_process: GO:0006401 - RNA catabolic process [Evidence IMP] [PMID 19332891]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IGI] [PMID 19332891]; GO_process: GO:0000902 - cell morphogenesis [Evidence IMP] [PMID 11158587]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
ribonucleotide-diphosphate reductase subunit RNR1
similar to AA sequence:KEGG_Orthology:K10807
Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12732713]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9315670]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IEA]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IDA] [PMID 10716984]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IDA] [PMID 16537479]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA,IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10535923]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10716984]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 11893751]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IMP] [PMID 8552025]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 10535923]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 5459124]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K08334
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has a novel globular fold that is essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of the higher eukaryotic gene Beclin 1; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9105038]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 9105038]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 9712845]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0034271 - phosphatidylinositol 3-kinase complex I [Evidence IDA] [PMID 11157979]; GO_component: GO:0034272 - phosphatidylinositol 3-kinase complex II [Evidence IDA] [PMID 11157979]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 9105038]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 9712845]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 22437838]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 11157979]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 11157979]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 21121900]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IMP] [PMID 12244127]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IGI,IMP] [PMID 12244127]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p); GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 22621929]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IBA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 22621929]
Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 11486013]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 9234685]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP,ISS] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP,ISS] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0006810 - transport [Evidence IEA]
Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12972564]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12972564]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12972564]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 12972564]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000920 - cytokinetic cell separation [Evidence IMP] [PMID 12972564]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 12972564]
similar to AA sequence:KEGG_Orthology:K07936
GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IGI,ISS] [PMID 8455603]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IGI,ISS] [PMID 8455603]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IEA]; GO_process: GO:0006997 - nucleus organization [Evidence IGI,ISS] [PMID 8455603]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03649
Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 22411836]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K01568
Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2665820]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16850348]; GO_function: GO:0047433 - branched-chain-2-oxoacid decarboxylase activity [Evidence IMP] [PMID 9546164]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 23423327]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 2404950]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IGI] [PMID 12499363]; GO_process: GO:0000955 - amino acid catabolic process via Ehrlich pathway [Evidence IEA]; GO_process: GO:0000949 - aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IDA] [PMID 2404950]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IDA] [PMID 2404950]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IGI] [PMID 12499363]
similar to AA sequence:KEGG_Orthology:K00968
Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity; GO_component: GO:0005794 - Golgi apparatus [Evidence TAS] [PMID 10397762]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 12200438]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12200438]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004105 - choline-phosphate cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0004105 - choline-phosphate cytidylyltransferase activity [Evidence IDA] [PMID 2826147]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006657 - CDP-choline pathway [Evidence IDA] [PMID 10397762]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA] [PMID 10397762]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10846
similar to AA sequence:KEGG_Orthology:K11376
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 22343726]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 22343726]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 15769872]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IEA]; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IMP] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12828
U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 12773561]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IPI,ISS] [PMID 10688664]
similar to AA sequence:KEGG_Orthology:K05292
Subunit of the glycosylphosphatidylinositol transamidase complex; transmembrane protein; adds GPIs to newly synthesized proteins; human PIG-Tp homolog; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 11598210]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IC,IMP] [PMID 11598210]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 11598210]
similar to AA sequence:KEGG_Orthology:K02178
Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IMP,IPI] [PMID 10704439]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IDA,IPI] [PMID 11726501]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000075 - cell cycle checkpoint [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0032837 - distributive segregation [Evidence IMP] [PMID 15951820]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP] [PMID 10704439]
phosphoribosylaminoimidazole carboxylase ADE2
similar to AA sequence:KEGG_Orthology:K11808
Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004638 - phosphoribosylaminoimidazole carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004638 - phosphoribosylaminoimidazole carboxylase activity [Evidence IMP] [PMID 5767024]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IC] [PMID 5767024]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IMP] [PMID 8939809]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IC] [PMID 5767024]
Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17079729]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031310 - intrinsic component of vacuolar membrane [Evidence IDA] [PMID 12584253]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0033254 - vacuolar transporter chaperone complex [Evidence IPI] [PMID 11823419]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008976 - polyphosphate kinase activity [Evidence IDA] [PMID 19390046]; GO_process: GO:0016237 - microautophagy [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IMP] [PMID 11102525]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IMP] [PMID 19390046]; GO_process: GO:0007034 - vacuolar transport [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 11823419]
proteasome core particle subunit alpha 1
similar to AA sequence:KEGG_Orthology:K02730
Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12486
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA] [PMID 12627398]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IGI,ISS] [PMID 9677411]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14838
Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11583614]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10953080]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000915 - actomyosin contractile ring assembly [Evidence IMP] [PMID 14657029]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
diacylglycerol cholinephosphotransferase
similar to AA sequence:KEGG_Orthology:K00993
Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8543066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 2153142]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 3005242]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0004142 - diacylglycerol cholinephosphotransferase activity [Evidence IEA]; GO_function: GO:0004142 - diacylglycerol cholinephosphotransferase activity [Evidence IDA,IMP] [PMID 3029130]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006657 - CDP-choline pathway [Evidence IDA,IMP] [PMID 3029130]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K06287
similar to AA sequence:KEGG_Orthology:K15102
Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14756774]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005315 - inorganic phosphate transmembrane transporter activity [Evidence IDA] [PMID 14756774]; GO_process: GO:0006817 - phosphate ion transport [Evidence IDA] [PMID 14756774]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 14756774]; GO_process: GO:0006810 - transport [Evidence IEA]
PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15913452]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0016314 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [Evidence IEA]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA]; GO_function: GO:0008138 - protein tyrosine/serine/threonine phosphatase activity [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 11070083]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence NAS] [PMID 11395408]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 15913452]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]
hypothetical protein that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 20368989]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 15225602]; GO_process: GO:0016070 - RNA metabolic process [Evidence ISS] [PMID 15225602]; GO_process: GO:0016070 - RNA metabolic process [Evidence IPI] [PMID 16702403]
Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B; GO_component: GO:0000138 - Golgi trans cisterna [Evidence IDA] [PMID 22782902]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23625923]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0031573 - intra-S DNA damage checkpoint [Evidence IMP] [PMID 22782902]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 22782902]; GO_process: GO:0000321 - re-entry into mitotic cell cycle after pheromone arrest [Evidence IGI] [PMID 12588993]
similar to AA sequence:KEGG_Orthology:K01648
similar to AA sequence:KEGG_Orthology:K11483
Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0017136 - NAD-dependent histone deacetylase activity [Evidence IDA] [PMID 11711434]; GO_function: GO:0032041 - NAD-dependent histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0097372 - NAD-dependent histone deacetylase activity (H3-K18 specific) [Evidence IEA]; GO_function: GO:0046969 - NAD-dependent histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0046970 - NAD-dependent histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0045129 - NAD-independent histone deacetylase activity [Evidence IDA] [PMID 11711434]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IEA]; GO_function: GO:0031078 - histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0032129 - histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0034739 - histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence ISS] [PMID 8962081]; GO_process: GO:0070932 - histone H3 deacetylation [Evidence IEA]; GO_process: GO:0070933 - histone H4 deacetylation [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 11711434]; GO_process: GO:0032874 - positive regulation of stress-activated MAPK cascade [Evidence IMP] [PMID 18487345]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 19379692]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence ISS] [PMID 8962081]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06669
Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 9990856]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence TAS] [PMID 9887095]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10412984]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0051177 - meiotic sister chromatid cohesion [Evidence IMP] [PMID 10412984]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 9335333]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10412984]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 10412984]
similar to AA sequence:KEGG_Orthology:K15105
Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015183 - L-aspartate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0005313 - L-glutamate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015297 - antiporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015292 - uniporter activity [Evidence IDA] [PMID 14622413]; GO_process: GO:0015813 - L-glutamate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015810 - aspartate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0044271 - cellular nitrogen compound biosynthetic process [Evidence IMP] [PMID 14622413]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11838
Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 21665945]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 10527495]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 21665945]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 21710968]; GO_process: GO:0016579 - protein deubiquitination [Evidence ISA] [PMID 19734957]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA,IMP] [PMID 21665945]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18470
Non-essential hypothetical protein; promoter contains a consensus binding sequence for factor Abf1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase
similar to AA sequence:KEGG_Orthology:K00549
similar to AA sequence:KEGG_Orthology:K15128
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA] [PMID 9234719]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 9234719]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 9234719]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
hypothetical protein; required for survival upon exposure to K1 killer toxin; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K01522
Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0047710 - bis(5'-adenosyl)-triphosphatase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IDA] [PMID 12028594]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IDA] [PMID 1653209]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009164 - nucleoside catabolic process [Evidence IMP] [PMID 9573184]
calmodulin-dependent protein kinase CMK1
similar to AA sequence:KEGG_Orthology:K00511
Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9450962]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 9450962]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0008144 - drug binding [Evidence IMP] [PMID 14638499]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IMP] [PMID 200835]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IDA] [PMID 9450962]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01638
Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0009514 - glyoxysome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IMP] [PMID 23642236]; GO_function: GO:0004474 - malate synthase activity [Evidence IDA] [PMID 8462696]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IDA] [PMID 8462696]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12399
Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IEA]; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IMP] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04393
Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8167411]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8167411]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 23906065]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 22323294]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 23468594]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10066831]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 11003652]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IMP] [PMID 11595741]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI,IPI] [PMID 19955214]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IMP] [PMID 12234925]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11595741]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 14734532]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IMP] [PMID 14517318]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
chaperonin-containing T-complex alpha subunit TCP1
similar to AA sequence:KEGG_Orthology:K09493
Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 18675371]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11533229]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 18675371]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 16055745]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071456 - cellular response to hypoxia [Evidence IMP] [PMID 19807692]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11533229]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16055745]; GO_process: GO:0035969 - positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12077145]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11238402]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03627
Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9710580]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IDA] [PMID 9710580]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9710580]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11359917]; GO_component: GO:0005795 - Golgi stack [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,IMP,IPI,ISS] [PMID 10508155]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IDA] [PMID 11118206]
methylenetetrahydrofolate dehydrogenase (NAD(+))
similar to AA sequence:KEGG_Orthology:K00295
NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8608153]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity [Evidence IMP,ISS] [PMID 8416923]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IMP] [PMID 8608153]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IDA,IMP] [PMID 8608153]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IDA,IMP] [PMID 8608153]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14847
Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11864606]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 11864607]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0008312 - 7S RNA binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0019843 - rRNA binding [Evidence IPI] [PMID 11864606]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11864607]
similar to AA sequence:KEGG_Orthology:K14300
Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 21818277]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI] [PMID 15725626]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16418532]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 17538013]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 18258809]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0035392 - maintenance of chromatin silencing at telomere [Evidence IMP] [PMID 16418532]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 22331846]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 7813444]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 7862658]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9725905]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 21036941]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 7813444]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA,IGI] [PMID 15817685]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 8524308]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 16418532]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11567
Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; GO_component: GO:0042729 - DASH complex [Evidence IEA]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15640796]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15664196]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0072686 - mitotic spindle [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 15664196]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 16777964]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 17620411]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 20479465]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 17620411]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479465]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479468]; GO_process: GO:0031116 - positive regulation of microtubule polymerization [Evidence IDA] [PMID 15664196]
Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 19073882]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 19073882]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 7615633]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 15835919]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 22114349]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 15835919]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0051601 - exocyst localization [Evidence IMP] [PMID 19073882]; GO_process: GO:0006887 - exocytosis [Evidence IEA,IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0035544 - negative regulation of SNARE complex assembly [Evidence IDA,IPI] [PMID 15835919]; GO_process: GO:0035544 - negative regulation of SNARE complex assembly [Evidence IDA,IGI,IPI] [PMID 22114349]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
polysaccharide deacetylase family protein
EEH16864|polysaccharide deacetylase family protein [Paracoccidioides brasiliensis Pb03]
cyclin-dependent serine/threonine protein kinase CTK1
similar to AA sequence:KEGG_Orthology:K08818
similar to AA sequence:KEGG_Orthology:K16075
Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10400670]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IDA] [PMID 12628916]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015693 - magnesium ion transport [Evidence IEA]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IDA] [PMID 12628916]; GO_process: GO:0006810 - transport [Evidence IEA]
cyclin-dependent serine/threonine protein kinase SGV1
similar to AA sequence:KEGG_Orthology:K15562
similar to AA sequence:KEGG_Orthology:K07512
2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11509667]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004319 - enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Evidence IEA]; GO_function: GO:0016631 - enoyl-[acyl-carrier-protein] reductase activity [Evidence IDA] [PMID 11509667]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0019166 - trans-2-enoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 11509667]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IMP] [PMID 11509667]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
putative E2 ubiquitin-protein ligase UBC11
similar to AA sequence:KEGG_Orthology:K06688
Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISS] [PMID 9675819]; GO_process: GO:0006513 - protein monoubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0000209 - protein polyubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09250
Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23285195]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23285195]; GO_component: GO:0042788 - polysomal ribosome [Evidence IPI] [PMID 21277287]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21232131]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 21232131]; GO_function: GO:0045182 - translation regulator activity [Evidence IDA] [PMID 21277287]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IDA] [PMID 21277287]
similar to AA sequence:KEGG_Orthology:K03240
Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IGI,IPI] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IMP] [PMID 8441423]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IPI] [PMID 8336705]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA,IPI] [PMID 9472020]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 10805739]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 12356745]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 9472020]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IGI,IPI] [PMID 8336705]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8336705]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11231
Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10198019]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14665464]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8808622]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0009927 - histidine phosphotransfer kinase activity [Evidence IDA,IMP] [PMID 12455952]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005034 - osmosensor activity [Evidence IDA] [PMID 12821642]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IDA] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IGI,IMP] [PMID 9482735]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0018106 - peptidyl-histidine phosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA,IEA]; GO_process: GO:0046777 - protein autophosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0023014 - signal transduction by phosphorylation [Evidence IEA]
hypothetical protein; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence TAS] [PMID 10679030]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence TAS] [PMID 10679030]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 10679030]
similar to AA sequence:KEGG_Orthology:K03854
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 7975899]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 7975899]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence ISS] [PMID 7975899]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
putative serine/threonine protein kinase KIC1
similar to AA sequence:KEGG_Orthology:K08838
oxygen-dependent protoporphyrinogen oxidase
similar to AA sequence:KEGG_Orthology:K00231
Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7798202]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004729 - oxygen-dependent protoporphyrinogen oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004729 - oxygen-dependent protoporphyrinogen oxidase activity [Evidence IMP] [PMID 7052077]; GO_function: GO:0004729 - oxygen-dependent protoporphyrinogen oxidase activity [Evidence IDA] [PMID 7798202]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08495
v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 16699523]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA,IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 11959998]; GO_component: GO:0005801 - cis-Golgi network [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS,NAS] [PMID 9755865]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11959998]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IMP] [PMID 9755865]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11959998]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13535
Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23637464]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19244244]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004623 - phospholipase A2 activity [Evidence IDA,IMP] [PMID 19244244]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 19244244]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 23637464]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IDA,IGI] [PMID 19244244]
similar to AA sequence:KEGG_Orthology:K01897
Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IGI,IMP] [PMID 11477098]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IGI] [PMID 22633490]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IDA] [PMID 7650027]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001676 - long-chain fatty acid metabolic process [Evidence IEA]; GO_process: GO:0015909 - long-chain fatty acid transport [Evidence IGI] [PMID 12601005]; GO_process: GO:0035336 - long-chain fatty-acyl-CoA metabolic process [Evidence IGI,IMP] [PMID 11477098]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14297
Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044613 - nuclear pore central transport channel [Evidence IDA] [PMID 18046406]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 9305650]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8044840]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0005487 - nucleocytoplasmic transporter activity [Evidence IPI] [PMID 17418788]; GO_function: GO:0005487 - nucleocytoplasmic transporter activity [Evidence IGI] [PMID 20647373]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IPI] [PMID 17418788]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0006607 - NLS-bearing protein import into nucleus [Evidence IGI] [PMID 15039779]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16418532]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0035392 - maintenance of chromatin silencing at telomere [Evidence IMP] [PMID 16418532]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8195299]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9001245]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9133678]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9305650]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 8044840]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 9001245]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 9133678]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 9305650]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA] [PMID 15817685]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 20647373]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IGI] [PMID 21659568]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 8524308]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 10638763]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 11862215]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 16418532]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15728363]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8921898]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IDA] [PMID 17401378]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP,ISS] [PMID 8921898]; GO_function: GO:0005506 - iron ion binding [Evidence IMP,IPI] [PMID 15728363]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15728363]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 17401378]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K11654
ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide; GO_component: GO:0008623 - CHRAC [Evidence IPI,ISS] [PMID 14673157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11238381]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 19203228]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16227570]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19203228]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 11238381]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA,IMP] [PMID 16227570]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 17689493]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 14673157]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17689493]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IGI] [PMID 18075583]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP] [PMID 12624196]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 15116071]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 17949749]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16227570]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI] [PMID 12504018]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00432
Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21763276]; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 21763276]; GO_component: GO:0031315 - extrinsic component of mitochondrial outer membrane [Evidence IDA] [PMID 21763276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IEA,IEA]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IMP,ISS] [PMID 10480913]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 11445588]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 11875065]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0047066 - phospholipid-hydroperoxide glutathione peroxidase activity [Evidence IDA,IMP] [PMID 11445588]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11445588]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14679
tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 3312232]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 20844078]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IDA] [PMID 6297798]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0051730 - GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [Evidence IDA] [PMID 8428918]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3277966]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3512545]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 8898194]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0032056 - positive regulation of translation in response to stress [Evidence IMP,IPI] [PMID 20844078]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IMP] [PMID 1537841]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IDA] [PMID 2207062]
similar to AA sequence:KEGG_Orthology:K00938
Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004631 - phosphomevalonate kinase activity [Evidence IEA]; GO_function: GO:0004631 - phosphomevalonate kinase activity [Evidence IMP] [PMID 1846667]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0031388 - organic acid phosphorylation [Evidence IMP] [PMID 200835]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01764
Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 7559417]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IEA]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IMP,ISS] [PMID 1499554]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IMP,ISS] [PMID 1499554]
similar to AA sequence:KEGG_Orthology:K17778
Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IDA] [PMID 9822593]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IDA] [PMID 9889188]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9430585]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9495346]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 12138093]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IEA]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IMP] [PMID 9430585]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IDA] [PMID 9495346]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03259
mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8119957]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence TAS] [PMID 9841679]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8119957]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 3062383]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA,IPI] [PMID 15753296]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 2540596]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence ISS] [PMID 3062383]
Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 20578725]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17588950]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20709757]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IMP] [PMID 20578725]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP] [PMID 17588950]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IMP] [PMID 17588950]; GO_process: GO:0006818 - hydrogen transport [Evidence IMP] [PMID 20578725]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006813 - potassium ion transport [Evidence IMP] [PMID 17588950]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IMP] [PMID 17588950]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
trans-2-enoyl-CoA reductase (NADPH) TSC13
similar to AA sequence:KEGG_Orthology:K10258
Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA,IGI,ISS] [PMID 11113186]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IMP,ISS] [PMID 11113186]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0000038 - very long-chain fatty acid metabolic process [Evidence IGI,IMP,IPI] [PMID 11113186]
non-specific serine/threonine protein kinase
Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004672 - protein kinase activity [Evidence ISS] [PMID 9020587]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]
similar to AA sequence:KEGG_Orthology:K01869
Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9742237]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IDA] [PMID 9742237]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IDA] [PMID 9742237]; GO_process: GO:0032006 - regulation of TOR signaling [Evidence IMP,IPI] [PMID 22424774]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03241
Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA,IPI] [PMID 9472020]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 9472020]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 11707417]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP,IPI] [PMID 2038327]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 1986242]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 2038327]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IMP] [PMID 3516411]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 3915540]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
proteasome regulatory particle base subunit RPT4
similar to AA sequence:KEGG_Orthology:K03064
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10419517]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8955118]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA] [PMID 11418596]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18174173]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI] [PMID 11410533]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11389845]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10863
DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0033699 - DNA 5'-adenosine monophosphate hydrolase activity [Evidence IDA] [PMID 16964241]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 20399152]
similar to AA sequence:KEGG_Orthology:K10956
Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 8612571]; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 9252322]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IMP] [PMID 1550957]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IDA] [PMID 9252322]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 10758167]; GO_function: GO:0005048 - signal sequence binding [Evidence IDA] [PMID 12134063]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 19696741]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 24314051]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 11076036]; GO_process: GO:0044743 - intracellular protein transmembrane import [Evidence IMP] [PMID 24314051]; GO_process: GO:0070843 - misfolded protein transport [Evidence IMP] [PMID 24314051]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 7758110]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 9252322]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 9843581]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 10635318]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 9303298]; GO_process: GO:0006810 - transport [Evidence IEA]
Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication; GO_component: GO:0030287 - cell wall-bounded periplasmic space [Evidence IDA] [PMID 383482]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 383482]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0042597 - periplasmic space [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 6352682]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043171 - peptide catabolic process [Evidence IMP] [PMID 3286257]; GO_process: GO:0043171 - peptide catabolic process [Evidence IDA] [PMID 6352682]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 10072385]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IMP] [PMID 10072385]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0048026 - positive regulation of mRNA splicing, via spliceosome [Evidence IMP] [PMID 10983980]
similar to AA sequence:KEGG_Orthology:K14960
Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18845545]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IMP] [PMID 11752412]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11805083]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11687631]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11752412]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11805083]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 11687631]
similar to AA sequence:KEGG_Orthology:K10752
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8858151]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9575221]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 14761951]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA,IPI] [PMID 8858151]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 9575221]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14761951]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9575221]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 8858151]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 9575221]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 8858151]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 8858151]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 10982821]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 8858151]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 9575221]
similar to AA sequence:KEGG_Orthology:K14319
GTPase activating protein (GAP) for Gsp1p; involved in nuclear transport; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2116418]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8755533]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8755533]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005098 - Ran GTPase activator activity [Evidence IEA]; GO_function: GO:0005098 - Ran GTPase activator activity [Evidence IMP] [PMID 7657689]; GO_function: GO:0005098 - Ran GTPase activator activity [Evidence IDA] [PMID 9305944]; GO_process: GO:0006404 - RNA import into nucleus [Evidence IMP] [PMID 16040803]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17904525]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032853 - positive regulation of Ran GTPase activity [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IDA] [PMID 7657689]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 22008473]
Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12504007]; GO_function: GO:0001671 - ATPase activator activity [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 12504007]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 12604615]; GO_function: GO:0051087 - chaperone binding [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence IDA] [PMID 12504007]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 12504007]; GO_process: GO:0032781 - positive regulation of ATPase activity [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP,IPI] [PMID 12504007]; GO_process: GO:0006950 - response to stress [Evidence IEA,IEA]
putative vacuolar protein sorting protein
similar to S. cerevisiae VPS72 (YDR485C) involved in vacuolar protein sorting; Ca20C1.06c; allele of CaO19.3399
Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IDA] [PMID 9046085]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation [Evidence TAS] [PMID 10950302]
3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3
similar to AA sequence:KEGG_Orthology:K02858
3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12595523]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 12595523]; GO_function: GO:0008686 - 3,4-dihydroxy-2-butanone-4-phosphate synthase activity [Evidence IEA,IEA]; GO_function: GO:0008686 - 3,4-dihydroxy-2-butanone-4-phosphate synthase activity [Evidence IMP] [PMID 7559556]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 12595523]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]
similar to AA sequence:KEGG_Orthology:K08832
similar to AA sequence:KEGG_Orthology:K12737
Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01885
Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IDA] [PMID 11069915]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19417106]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence IDA] [PMID 11069915]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence IDA] [PMID 11069915]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
Cytosolic protein required for sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15178
Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 12682017]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 20732871]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21737840]; GO_process: GO:0016570 - histone modification [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15180994]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:0034402 - recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 18469135]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 12667454]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 12876293]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IMP] [PMID 17576814]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:2001166 - regulation of histone H2B ubiquitination [Evidence IMP] [PMID 12876293]; GO_process: GO:2001166 - regulation of histone H2B ubiquitination [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12667454]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12876293]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 15180994]; GO_process: GO:2001160 - regulation of histone H3-K79 methylation [Evidence IMP] [PMID 12876293]; GO_process: GO:2001163 - regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 15149594]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 11884586]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 16246725]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IMP] [PMID 16246725]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11927560]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
similar to AA sequence:KEGG_Orthology:K12659
Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 1851947]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003942 - N-acetyl-gamma-glutamyl-phosphate reductase activity [Evidence IEA,IEA]; GO_function: GO:0003942 - N-acetyl-gamma-glutamyl-phosphate reductase activity [Evidence IDA] [PMID 1851947]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003991 - acetylglutamate kinase activity [Evidence IEA,IEA]; GO_function: GO:0003991 - acetylglutamate kinase activity [Evidence IDA] [PMID 1851947]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 12603335]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence TAS] [PMID 1851947]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 15486299]
similar to AA sequence:KEGG_Orthology:K10627
E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA; GO_component: GO:0097505 - Rad6-Rad18 complex [Evidence IDA] [PMID 9287349]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10880451]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10880451]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 7926769]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9287349]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 9287349]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0042275 - error-free postreplication DNA repair [Evidence IGI] [PMID 10924462]; GO_process: GO:0042275 - error-free postreplication DNA repair [Evidence IGI] [PMID 9576943]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IGI] [PMID 9409821]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 11973297]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 15687278]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IMP] [PMID 12226657]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12361950]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12523934]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12361950]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12523934]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA,IMP] [PMID 12361950]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 12523934]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA,IMP] [PMID 12361950]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 12523934]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; YPS1 has a paralog, MKC7, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA] [PMID 8389368]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 8626758]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 22028670]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IMP] [PMID 22028670]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055088 - lipid homeostasis [Evidence IMP] [PMID 22028670]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01480
Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004053 - arginase activity [Evidence IEA,IEA]; GO_function: GO:0004053 - arginase activity [Evidence IMP] [PMID 14582193]; GO_function: GO:0004053 - arginase activity [Evidence IDA] [PMID 2404017]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016813 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IDA] [PMID 1939179]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0090369 - ornithine carbamoyltransferase inhibitor activity [Evidence IDA,IMP] [PMID 12679340]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 1939179]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IMP] [PMID 14582193]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IDA] [PMID 2404017]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA,IEA]; GO_process: GO:0090368 - regulation of ornithine metabolic process [Evidence IDA,IMP] [PMID 12679340]; GO_process: GO:0000050 - urea cycle [Evidence IEA]
Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11427965]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11427965]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 11427965]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 17714445]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 17761529]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 11427965]
similar to AA sequence:KEGG_Orthology:K08783
Putative metalloprotease with similarity to zinc carboxypeptidases; required for normal cell wall assembly; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004181 - metallocarboxypeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence ISS] [PMID 15606766]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence ISS] [PMID 15606766]
N-glycosylated protein; involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11110666]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15356260]; GO_component: GO:0005621 - cellular bud scar [Evidence IDA] [PMID 11110666]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 11110666]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IGI,IMP] [PMID 11110666]
similar to AA sequence:KEGG_Orthology:K01883
Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004817 - cysteine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004817 - cysteine-tRNA ligase activity [Evidence IDA] [PMID 9523015]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006423 - cysteinyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006423 - cysteinyl-tRNA aminoacylation [Evidence IDA] [PMID 9523015]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress; GO_component: GO:0030287 - cell wall-bounded periplasmic space [Evidence IDA] [PMID 15128531]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15128531]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IMP] [PMID 7502577]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IMP] [PMID 7502577]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0071465 - cellular response to desiccation [Evidence IMP] [PMID 8633854]; GO_process: GO:0071361 - cellular response to ethanol [Evidence IMP] [PMID 8633854]; GO_process: GO:0071497 - cellular response to freezing [Evidence IMP] [PMID 8633854]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IMP] [PMID 7502577]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IDA,IMP,ISS] [PMID 8764988]
similar to AA sequence:KEGG_Orthology:K17278
Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17954932]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 12684380]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IDA] [PMID 15713626]; GO_process: GO:0032443 - regulation of ergosterol biosynthetic process [Evidence IGI] [PMID 15713626]; GO_process: GO:0032443 - regulation of ergosterol biosynthetic process [Evidence IMP] [PMID 17954932]
similar to AA sequence:KEGG_Orthology:K04648
Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued); GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 19403691]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 19403691]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005869 - dynactin complex [Evidence IDA] [PMID 9658168]; GO_component: GO:0030286 - dynein complex [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 19403691]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9658168]; GO_function: GO:0008017 - microtubule binding [Evidence ISS] [PMID 9658168]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP] [PMID 9658168]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03857
UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IMP] [PMID 9079905]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000506 - glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [Evidence TAS] [PMID 11102867]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008194 - UDP-glycosyltransferase activity [Evidence ISS] [PMID 10970797]; GO_function: GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence ISS] [PMID 8081362]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]
Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 16456538]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IGI] [PMID 19369420]
Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0070577 - lysine-acetylated histone binding [Evidence IDA] [PMID 20126658]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA,IDA] [PMID 12183366]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03509
DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 23313845]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23313845]; GO_component: GO:0005657 - replication fork [Evidence IPI] [PMID 11545742]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 10601233]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 9974380]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 23326240]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 10713149]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 10932195]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 11027270]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 9974380]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 10713149]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 12110599]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 16387871]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 23326240]
Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 12455697]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0005275 - amine transmembrane transporter activity [Evidence IMP] [PMID 12455697]; GO_process: GO:0015837 - amine transport [Evidence IMP] [PMID 12455697]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 12455697]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 12455697]; GO_process: GO:0006810 - transport [Evidence IEA]
proteasome regulatory particle lid subunit RPN12
similar to AA sequence:KEGG_Orthology:K03031
Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005838 - proteasome regulatory particle [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10490625]
mitochondrial 37S ribosomal protein MRPS35
Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
similar to AA sequence:KEGG_Orthology:K04646
Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function; GO_component: GO:0030132 - clathrin coat of coated pit [Evidence IEA]; GO_component: GO:0030130 - clathrin coat of trans-Golgi network vesicle [Evidence IEA]; GO_component: GO:0030125 - clathrin vesicle coat [Evidence TAS] [PMID 9171338]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence TAS] [PMID 9171338]; GO_process: GO:0006897 - endocytosis [Evidence IDA,IMP] [PMID 16643280]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence TAS] [PMID 9171338]
similar to AA sequence:KEGG_Orthology:K07575
hypothetical protein that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 23613772]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 10093218]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 16702403]; GO_process: GO:0006412 - translation [Evidence IEA]
Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_function: GO:0043014 - alpha-tubulin binding [Evidence IPI] [PMID 9885248]; GO_process: GO:0006457 - protein folding [Evidence IGI,ISS] [PMID 9215891]; GO_process: GO:0007021 - tubulin complex assembly [Evidence IGI] [PMID 9215891]; GO_process: GO:0072668 - tubulin complex biogenesis [Evidence IMP] [PMID 9215891]
mitochondrial 54S ribosomal protein YmL17/YmL30
similar to AA sequence:KEGG_Orthology:K17427
similar to AA sequence:KEGG_Orthology:K12880
similar to AA sequence:KEGG_Orthology:K15560
Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence ISS] [PMID 10769178]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 17397106]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K19691
similar to AA sequence:KEGG_Orthology:K00972
UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003977 - UDP-N-acetylglucosamine diphosphorylase activity [Evidence IEA]; GO_function: GO:0003977 - UDP-N-acetylglucosamine diphosphorylase activity [Evidence IDA] [PMID 9603950]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IDA] [PMID 9603950]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10865
similar to AA sequence:KEGG_Orthology:K02894
Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04728
mitochondrial 37S ribosomal protein RSM25
similar to AA sequence:KEGG_Orthology:K17402
Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00162
similar to AA sequence:KEGG_Orthology:K00318
Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3125423]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004657 - proline dehydrogenase activity [Evidence IEA]; GO_function: GO:0004657 - proline dehydrogenase activity [Evidence IDA] [PMID 20450881]; GO_function: GO:0004657 - proline dehydrogenase activity [Evidence IMP] [PMID 387737]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IC] [PMID 387737]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006562 - proline catabolic process [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IDA] [PMID 20450881]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IMP] [PMID 387737]; GO_process: GO:0006560 - proline metabolic process [Evidence IEA]
Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 13679573]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 22250200]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 23237950]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23237950]; GO_function: GO:0005544 - calcium-dependent phospholipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 15049706]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0090158 - endoplasmic reticulum membrane organization [Evidence IGI] [PMID 23237950]; GO_process: GO:0060304 - regulation of phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 23237950]
t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 9195974]; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 7954793]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 16339720]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISS] [PMID 7954793]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence TAS] [PMID 10047442]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 12913108]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11001046]
similar to AA sequence:KEGG_Orthology:K06927
Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0017178 - diphthine-ammonia ligase activity [Evidence IEA]; GO_function: GO:0017178 - diphthine-ammonia ligase activity [Evidence IDA,IMP] [PMID 23169644]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IDA,IMP] [PMID 23169644]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 23468660]
similar to AA sequence:KEGG_Orthology:K00794
Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0009349 - riboflavin synthase complex [Evidence IEA]; GO_function: GO:0000906 - 6,7-dimethyl-8-ribityllumazine synthase activity [Evidence IGI,ISS] [PMID 7559556]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 7559556]
Nucleolar protein required for 60S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9891085]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9891085]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 9891085]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15176
Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 10219085]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10219085]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 15531585]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 11884586]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_function: GO:0045142 - triplex DNA binding [Evidence IDA] [PMID 11058104]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:2001255 - positive regulation of histone H3-K36 trimethylation [Evidence IMP] [PMID 17948059]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 18194564]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12667454]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 18194564]; GO_process: GO:0060260 - regulation of transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 18194564]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10219085]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 16246725]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IMP] [PMID 16246725]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 19164765]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 11927560]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IGI] [PMID 20299458]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12588995]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IMP,ISS] [PMID 12588995]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 12588995]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
similar to AA sequence:KEGG_Orthology:K00021
HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8744950]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 3065625]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 8744950]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity [Evidence IEA,IEA]; GO_function: GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity [Evidence IMP] [PMID 2828155]; GO_function: GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity [Evidence IDA] [PMID 3526336]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0015936 - coenzyme A metabolic process [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 9292983]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IC] [PMID 3526336]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15443
Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0043527 - tRNA methyltransferase complex [Evidence IDA] [PMID 12403464]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IMP] [PMID 12403464]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IDA] [PMID 17382321]; GO_process: GO:0036265 - RNA (guanine-N7)-methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 12403464]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 17382321]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16794
Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005875 - microtubule associated complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15965467]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_function: GO:0045502 - dynein binding [Evidence IEA]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 15965467]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006928 - cellular component movement [Evidence IEA]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IEA]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 12566428]; GO_process: GO:2000582 - positive regulation of plus-end-directed microtubule motor activity [Evidence IMP] [PMID 22939623]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16302
Protein required for normal mitochondrial morphology; has similarity to hemolysins; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 15498024]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 10628851]
similar to AA sequence:KEGG_Orthology:K11173
Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IMP] [PMID 3023838]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3282541]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006113 - fermentation [Evidence IMP] [PMID 3023838]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K09043
bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase
similar to AA sequence:KEGG_Orthology:K01196
Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IBA]; GO_function: GO:0004134 - 4-alpha-glucanotransferase activity [Evidence IEA,IEA]; GO_function: GO:0004134 - 4-alpha-glucanotransferase activity [Evidence IDA,IMP] [PMID 11094287]; GO_function: GO:0004135 - amylo-alpha-1,6-glucosidase activity [Evidence IEA,IEA]; GO_function: GO:0004135 - amylo-alpha-1,6-glucosidase activity [Evidence IDA,IMP] [PMID 11094287]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IMP] [PMID 11094287]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
DNA-directed RNA polymerase core subunit RPB6
similar to AA sequence:KEGG_Orthology:K03014
RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IEA]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12697831]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IMP] [PMID 12697831]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9726978]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11120744]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IGI] [PMID 11120744]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 10341420]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 9726978]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015891 - siderophore transport [Evidence IMP] [PMID 9726978]
similar to AA sequence:KEGG_Orthology:K04460
Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12694636]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12694636]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 12694636]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence ISS] [PMID 7925273]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA,ISS] [PMID 7925273]
similar to AA sequence:KEGG_Orthology:K14839
Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01809
Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004476 - mannose-6-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004476 - mannose-6-phosphate isomerase activity [Evidence IDA] [PMID 8011630]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IMP] [PMID 1377774]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 1377774]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 1377774]
similar to AA sequence:KEGG_Orthology:K10427
SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12391157]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16824951]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 16824951]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 12391157]; GO_process: GO:0045010 - actin nucleation [Evidence IMP] [PMID 16824951]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 16231105]; GO_process: GO:0009651 - response to salt stress [Evidence IGI,IPI] [PMID 12391157]
Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 8702493]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IPI] [PMID 10889207]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 8702493]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 8702493]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K08501
Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 7607232]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence ISA] [PMID 7607232]; GO_function: GO:0050561 - glutamate-tRNA(Gln) ligase activity [Evidence IDA] [PMID 15706032]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence ISA] [PMID 7607232]; GO_process: GO:0070149 - mitochondrial glutamyl-tRNA aminoacylation [Evidence IC] [PMID 7607232]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7607232]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IEA]; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IDA] [PMID 15738391]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11927594]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 21293191]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 15738391]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 16793545]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 21293191]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11927594]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15738391]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0051304 - chromosome separation [Evidence IMP] [PMID 15793567]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IEA]; GO_process: GO:0000725 - recombinational repair [Evidence IPI] [PMID 19995966]; GO_process: GO:0071139 - resolution of recombination intermediates [Evidence IMP] [PMID 20159973]
similar to AA sequence:KEGG_Orthology:K18703
similar to AA sequence:KEGG_Orthology:K09680
Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004594 - pantothenate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004594 - pantothenate kinase activity [Evidence IMP] [PMID 19266201]; GO_function: GO:0004594 - pantothenate kinase activity [Evidence ISS] [PMID 9890959]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 9890959]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00988
AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003877 - ATP adenylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008796 - bis(5'-nucleosyl)-tetraphosphatase activity [Evidence IDA,IGI,IMP] [PMID 2174863]; GO_function: GO:0008796 - bis(5'-nucleosyl)-tetraphosphatase activity [Evidence IDA,IMP] [PMID 2556364]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004780 - sulfate adenylyltransferase (ADP) activity [Evidence IEA]; GO_function: GO:0004780 - sulfate adenylyltransferase (ADP) activity [Evidence IDA,IMP] [PMID 2556364]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009164 - nucleoside catabolic process [Evidence IDA,IGI,IMP] [PMID 2174863]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IDA] [PMID 2172926]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15507
Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 8643404]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008989 - rRNA (guanine-N1-)-methyltransferase activity [Evidence IDA] [PMID 8643404]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IDA] [PMID 8643404]
ubiquinol--cytochrome-c reductase subunit 7
similar to AA sequence:KEGG_Orthology:K00417
Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IMP] [PMID 2540976]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 2540976]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IMP] [PMID 2540976]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 11556808]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
imidazoleglycerol-phosphate dehydratase HIS3
similar to AA sequence:KEGG_Orthology:K01693
Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004424 - imidazoleglycerol-phosphate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0004424 - imidazoleglycerol-phosphate dehydratase activity [Evidence IMP] [PMID 14190241]; GO_function: GO:0004424 - imidazoleglycerol-phosphate dehydratase activity [Evidence IDA] [PMID 341150]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IDA] [PMID 341150]
Putative hydrolase acting on ester bonds; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10251
similar to Coprinopsis cinerea okayama7#130 XP_001830383.1
similar to AA sequence:KEGG_Orthology:K11279
Histone chaperone; involved in histone exchange by removing and replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; involved in the transport of H2A and H2B histones to the nucleus; required for the regulation of microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7622566]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10767562]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0030332 - cyclin binding [Evidence IPI] [PMID 7622566]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 22308335]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 17289584]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 21348863]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 13680156]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 1400414]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA,ISS] [PMID 2016313]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IDA] [PMID 22308335]; GO_process: GO:0031116 - positive regulation of microtubule polymerization [Evidence IMP] [PMID 7622567]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 22308335]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12456659]
similar to AA sequence:KEGG_Orthology:K10589
Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 12408819]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0034450 - ubiquitin-ubiquitin ligase activity [Evidence IDA] [PMID 17190603]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17190603]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IMP] [PMID 22497224]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 17190603]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]
Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K08734
Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer; GO_component: GO:0032389 - MutLalpha complex [Evidence IPI] [PMID 10570173]; GO_component: GO:0097587 - MutLgamma complex [Evidence IPI] [PMID 9770499]; GO_component: GO:0005712 - chiasma [Evidence IBA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000795 - synaptonemal complex [Evidence IBA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 10938116]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 11717305]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0032139 - dinucleotide insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000713 - meiotic heteroduplex formation [Evidence IMP] [PMID 15654114]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 23316435]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 2685551]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10570173]
Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IEA]; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IDA] [PMID 15738391]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 15738391]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15738391]; GO_process: GO:0006281 - DNA repair [Evidence IMP,IPI] [PMID 15752197]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01409
Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0072670 - mitochondrial tRNA threonylcarbamoyladenosine modification [Evidence IMP] [PMID 21183954]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IEA]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IDA] [PMID 23620299]
similar to AA sequence:KEGG_Orthology:K00129
Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 8801420]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence ISS] [PMID 10407263]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IMP] [PMID 12586697]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019483 - beta-alanine biosynthetic process [Evidence IMP] [PMID 12586697]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence ISS] [PMID 10407263]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA]; GO_process: GO:0006598 - polyamine catabolic process [Evidence IGI,IMP] [PMID 12586697]
similar to AA sequence:KEGG_Orthology:K13628
Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10805735]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IDA] [PMID 21987576]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence ISA] [PMID 10748136]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IGI,IMP] [PMID 17259550]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 10748136]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI,IMP] [PMID 10805735]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12065597]
SCF ubiquitin ligase complex subunit CDC4
similar to AA sequence:KEGG_Orthology:K03361
F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346239]; GO_component: GO:0043224 - nuclear SCF ubiquitin ligase complex [Evidence IDA] [PMID 11080155]; GO_component: GO:0016363 - nuclear matrix [Evidence IDA] [PMID 2244914]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_function: GO:0050815 - phosphoserine binding [Evidence IDA] [PMID 23314252]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 328339]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 8649384]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 8514129]
Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15103330]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 15103330]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0008901 - ferredoxin hydrogenase activity [Evidence ISS] [PMID 10514485]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IDA] [PMID 19385603]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15103330]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 19385603]
similar to AA sequence:KEGG_Orthology:K00036
Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidative stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004345 - glucose-6-phosphate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004345 - glucose-6-phosphate dehydrogenase activity [Evidence IMP] [PMID 2001672]; GO_function: GO:0004345 - glucose-6-phosphate dehydrogenase activity [Evidence IMP] [PMID 2269430]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006740 - NADPH regeneration [Evidence IMP] [PMID 2269430]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0045013 - carbon catabolite repression of transcription [Evidence IMP] [PMID 2269430]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]; GO_process: GO:0009051 - pentose-phosphate shunt, oxidative branch [Evidence IMP] [PMID 7045591]; GO_process: GO:0009051 - pentose-phosphate shunt, oxidative branch [Evidence IMP] [PMID 8299150]; GO_process: GO:0042542 - response to hydrogen peroxide [Evidence IMP] [PMID 7586028]; GO_process: GO:0042542 - response to hydrogen peroxide [Evidence IMP] [PMID 9480895]
glucosamine 6-phosphate N-acetyltransferase
similar to AA sequence:KEGG_Orthology:K00621
Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004343 - glucosamine 6-phosphate N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004343 - glucosamine 6-phosphate N-acetyltransferase activity [Evidence IDA] [PMID 9867860]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IDA,IMP] [PMID 9867860]
Putative dihydrokaempferol 4-reductase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence ISA] [PMID 19577617]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01230
Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 21971548]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 21971548]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00262
NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 4126]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 11562373]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IDA,IMP] [PMID 2932370]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IDA,IMP] [PMID 2989290]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016639 - oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019676 - ammonia assimilation cycle [Evidence IEP] [PMID 11356843]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IGI] [PMID 2932370]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IGI] [PMID 2989290]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Probable type-III integral membrane hypothetical protein; has regions of similarity to mitochondrial electron transport proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 8635735]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K09503
Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1869583]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8144572]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 1869583]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 1400408]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9774392]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 10567418]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1473150]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IMP] [PMID 1729605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17774
Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; GO_component: GO:0032865 - ERMES complex [Evidence IEA,IEA]; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 13679517]; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 17410204]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0001401 - mitochondrial sorting and assembly machinery complex [Evidence IPI] [PMID 17410204]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051654 - establishment of mitochondrion localization [Evidence IMP] [PMID 13679517]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IEA]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP] [PMID 15239954]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP,IPI] [PMID 20026336]; GO_process: GO:0007005 - mitochondrion organization [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 19556461]; GO_process: GO:0015914 - phospholipid transport [Evidence IGI] [PMID 19556461]; GO_process: GO:0006461 - protein complex assembly [Evidence IEA]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IEA]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 17410204]
Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10077572]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IEA]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IDA] [PMID 10600176]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 10077572]
similar to AA sequence:KEGG_Orthology:K17769
Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as a receptor for precursor proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005742 - mitochondrial outer membrane translocase complex [Evidence IDA] [PMID 9774667]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 10519552]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 10519552]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 9774667]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 12628251]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IC] [PMID 9643541]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 19767828]
Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 10608875]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence TAS] [PMID 10608875]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0006827 - high-affinity iron ion transport [Evidence IPI] [PMID 10608875]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 16278452]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032366 - intracellular sterol transport [Evidence IGI,ISS] [PMID 16278452]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06237
similar to AA sequence:KEGG_Orthology:K09265
similar to AA sequence:KEGG_Orthology:K03263
Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IPI] [PMID 16215987]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 19120453]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IPI] [PMID 16215987]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IDA,IMP] [PMID 19424157]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 21451136]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IEA]; GO_process: GO:0045901 - positive regulation of translational elongation [Evidence IEA]; GO_process: GO:0045901 - positive regulation of translational elongation [Evidence IGI,IMP] [PMID 19338753]; GO_process: GO:0045901 - positive regulation of translational elongation [Evidence IDA,IMP] [PMID 19424157]; GO_process: GO:0045948 - positive regulation of translational initiation [Evidence IDA] [PMID 21451136]; GO_process: GO:0045905 - positive regulation of translational termination [Evidence IEA]; GO_process: GO:0045905 - positive regulation of translational termination [Evidence IDA] [PMID 19424157]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA]; GO_process: GO:0006452 - translational frameshifting [Evidence IEA]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 19424157]
Nitrogen catabolite repression transcriptional regulator; acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10748041]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IEA]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 15371425]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0051219 - phosphoprotein binding [Evidence IDA] [PMID 10604478]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IGI,IPI] [PMID 8755910]; GO_process: GO:0042994 - cytoplasmic sequestering of transcription factor [Evidence IMP] [PMID 10748041]; GO_process: GO:0042128 - nitrate assimilation [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IEA]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IMP] [PMID 8002570]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IGI,IPI] [PMID 8755910]; GO_process: GO:0010044 - response to aluminum ion [Evidence IMP] [PMID 15133656]
similar to AA sequence:KEGG_Orthology:K12492
ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IMP,IPI] [PMID 10069805]; GO_component: GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment [Evidence IPI] [PMID 9927415]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16452633]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16452633]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA,ISS] [PMID 8816753]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 15975906]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 10069805]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 9927415]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0030037 - actin filament reorganization involved in cell cycle [Evidence IGI,IMP,IPI] [PMID 10069805]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IGI,IMP] [PMID 9927415]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17491
Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 20951350]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA,IMP] [PMID 16299494]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA] [PMID 17517611]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IDA] [PMID 17517611]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 15598824]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 16299494]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 17517611]; GO_process: GO:1902660 - negative regulation of glucose mediated signaling pathway [Evidence IMP] [PMID 24277933]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 17517611]; GO_process: GO:0072462 - signal transduction involved in meiotic recombination checkpoint [Evidence IMP] [PMID 20951350]
hypothetical protein; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IMP] [PMID 14690608]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IMP] [PMID 12868057]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01405
Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8307027]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 8307027]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA,IMP,ISS] [PMID 8307027]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IDA,IMP] [PMID 8307027]
similar to AA sequence:KEGG_Orthology:K09699
Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045252 - oxoglutarate dehydrogenase complex [Evidence IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence ISA] [PMID 2115121]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence IMP] [PMID 2115121]; GO_process: GO:0033512 - L-lysine catabolic process to acetyl-CoA via saccharopine [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 10869431]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IC] [PMID 2072900]
similar to AA sequence:KEGG_Orthology:K01689
Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 16565073]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0000015 - phosphopyruvate hydratase complex [Evidence IEA]; GO_component: GO:0000015 - phosphopyruvate hydratase complex [Evidence IDA] [PMID 6282834]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004634 - phosphopyruvate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004634 - phosphopyruvate hydratase activity [Evidence IMP] [PMID 6282834]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 3313003]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 6282834]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 16565073]
similar to AA sequence:KEGG_Orthology:K10908
similar to Saccharomyces cerevisiae S288c NP_116617.1
hypothetical protein; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8065298]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IGI] [PMID 8065298]
Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10888667]; GO_component: GO:0032580 - Golgi cisterna membrane [Evidence IEA]; GO_component: GO:0070916 - inositol phosphoceramide synthase complex [Evidence IPI] [PMID 19726565]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0045140 - inositol phosphoceramide synthase activity [Evidence IDA] [PMID 19047657]; GO_function: GO:0045140 - inositol phosphoceramide synthase activity [Evidence IMP] [PMID 9092515]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IDA] [PMID 19726565]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 9092515]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15115
Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16291748]; GO_function: GO:0051724 - NAD transporter activity [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IMP] [PMID 12887330]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IDA] [PMID 16291748]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10930523]; GO_process: GO:0035352 - NAD transmembrane transport [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IMP] [PMID 12887330]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IDA] [PMID 16291748]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10930523]
similar to AA sequence:KEGG_Orthology:K01190
EFW99297|beta-galactosidase [Grosmannia clavigera kw1407]
Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0030118 - clathrin coat [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence TAS] [PMID 12461563]; GO_function: GO:0005543 - phospholipid binding [Evidence IEA]; GO_process: GO:0048268 - clathrin coat assembly [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IPI,ISS] [PMID 9531549]
similar to AA sequence:KEGG_Orthology:K00294
Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3025596]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity [Evidence IMP] [PMID 387737]; GO_function: GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity [Evidence IDA] [PMID 4145181]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IDA] [PMID 4145181]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IMP] [PMID 387737]; GO_process: GO:0006560 - proline metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00720
similar to AA sequence:KEGG_Orthology:K02896
Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 20670889]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 23185031]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 10760581]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]
similar to AA sequence:KEGG_Orthology:K15109
Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005476 - carnitine:acyl carnitine antiporter activity [Evidence IDA] [PMID 10545096]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IDA] [PMID 10545096]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16570
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000928 - gamma-tubulin small complex, spindle pole body [Evidence IPI] [PMID 9384578]; GO_component: GO:0005822 - inner plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005815 - microtubule organizing center [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005824 - outer plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9215630]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 9153752]
Protein localized to COPII vesicles; proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 16002643]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16002643]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]
potential ankyrin repeats near N terminus similar to S. cerevisiae YCR051W; allele of CaO19.2256
similar to AA sequence:KEGG_Orthology:K01754
Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IEA,IEA]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IMP] [PMID 5345980]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IMP] [PMID 5345980]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006567 - threonine catabolic process [Evidence IGI] [PMID 7042346]
Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 21168530]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 21168530]
hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12514182]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K17497
Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 3905826]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004615 - phosphomannomutase activity [Evidence IEA,IEA]; GO_function: GO:0004615 - phosphomannomutase activity [Evidence IDA] [PMID 3288631]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA]; GO_process: GO:0019307 - mannose biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 6368572]
similar to AA sequence:KEGG_Orthology:K02955
Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 9858605]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15125836]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 2277060]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8293976]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00052
Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 4355481]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IDA] [PMID 3071718]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IMP] [PMID 6297759]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 23642236]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 6297759]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03942
similar to AA sequence:KEGG_Orthology:K18573
Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 19837041]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19720832]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19720832]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA,IMP] [PMID 19720832]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IMP] [PMID 19837041]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 19720832]; GO_process: GO:0016485 - protein processing [Evidence IGI,IMP] [PMID 19837041]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 19837041]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8267570]; GO_function: GO:0015212 - cytidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 10501935]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IDA] [PMID 9092500]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015861 - cytidine transport [Evidence IDA,IMP] [PMID 10501935]; GO_process: GO:0015856 - cytosine transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0072530 - purine-containing compound transmembrane transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]